重组GII.13[P21]诺如病毒株的鉴定：分子动力学模拟表明基因突变改变了其与宿主受体聚糖的结合谱

IF 2.5 4区医学 Q3 VIROLOGY

Archives of Virology Pub Date : 2025-04-01 DOI:10.1007/s00705-025-06277-7

Yunfei Chen, Zexian Zhou, Lei Dong, Miao Jin, Yongjie Wang, Yongxin Yu

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引用次数: 0

摘要

人类诺如病毒是一种普遍存在的病原体，可引起病毒性肠胃炎的全球暴发。以往的研究表明，组织血型抗原（HBGAs）可与人诺如病毒相互作用，促进其进入宿主细胞并显著影响其进化。本研究分析了来自粪便样本的重组GII.13[P21]诺如病毒的全基因组序列。1978年至2019年对GII.13诺如病毒P蛋白的分子动力学模拟显示，它们与HBGAs结合的能力发生了变化。最初，GII.13蛋白结合A或B/H型HBGA，但随后的突变导致这种结合能力丧失，倾向于与HBGA I型前体（Lewis c）结合，而不是与A或B/H和Lewis抗原结合。

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Identification of a recombinant GII.13[P21] norovirus strain: molecular dynamic simulations indicate that gene mutations shifted its spectrum of binding to host receptor glycans

Human norovirus is a pervasive pathogen that causes global outbreaks of viral gastroenteritis. Previous studies have suggested that histo-blood group antigens (HBGAs) can interact with human norovirus, facilitating its entry of host cells and significantly affecting its evolution. In this study, the complete genome sequence of recombinant GII.13[P21] norovirus from fecal samples was analyzed. Molecular dynamics simulations of GII.13 norovirus P proteins from 1978 to 2019 showed changes in their capacity to bind to HBGAs. Initially, GII.13 proteins bound A or B/H-type HBGAs, but subsequent mutations resulted in a loss of this binding capacity, favoring binding to the HBGA type I precursor (Lewis c) over A or B/H and Lewis antigens.

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来源期刊

Archives of Virology 医学-病毒学

CiteScore

5.10

自引率

7.40%

发文量

324

审稿时长

4.5 months

期刊介绍： Archives of Virology publishes original contributions from all branches of research on viruses, virus-like agents, and virus infections of humans, animals, plants, insects, and bacteria. Coverage spans a broad spectrum of topics, from descriptions of newly discovered viruses, to studies of virus structure, composition, and genetics, to studies of virus interactions with host cells, organisms and populations. Studies employ molecular biologic, molecular genetics, and current immunologic and epidemiologic approaches. Contents include studies on the molecular pathogenesis, pathophysiology, and genetics of virus infections in individual hosts, and studies on the molecular epidemiology of virus infections in populations. Also included are studies involving applied research such as diagnostic technology development, monoclonal antibody panel development, vaccine development, and antiviral drug development.Archives of Virology wishes to publish obituaries of recently deceased well-known virologists and leading figures in virology.