Applied Organometallic Chemistry最新文献

{"title":"Synthesis, Characterization and Biological Activities of Tolfenamic Acid Alkaline Earth Metal Complexes","authors":"Shamima Akther,&nbsp;Saiful Islam,&nbsp;Md. Shahidur Rahman,&nbsp;Hasina Akhter Simol,&nbsp;A. H. M. Shofiul Islam Molla Jamal,&nbsp;Dipa Islam,&nbsp;Pradip K. Bakshi","doi":"10.1002/aoc.7779","DOIUrl":"https://doi.org/10.1002/aoc.7779","url":null,"abstract":"<div>\u0000 \u0000 <p>Solid complexes of tolfenamic acid (tolfH) with Mg(II), Ca(II), Sr(II), and Ba(II) have been synthesized and characterized by CHN, metal contents analysis, FTIR, UV, ¹H-NMR spectroscopy, thermal (TGA, DTG, DTA, and DSC) analysis, molar conductance, powder X-ray diffraction (XRD), and scanning electron microscopy (SEM–EDX). Based on these studies, the probable formulae for the complexes are [Mg(tolf)Cl(H₂O)₃].4H₂O, [Ca(tolf)₂(H₂O)₂], [Sr₂(tolf)₄(H₂O)₄], and [Ba₂(tolf)₄(H₂O)₄]. The ligand tolfenamate ion (tolf) exhibited different modes of coordination, including bidentate and chelating. The ¹H-NMR displayed the presence of tolfenamato ions in the coordination sphere, the purity and stability of the complexes in solution. The average crystallite sizes of the complexes were determined by XRD and ranged from 55 to 70 nm. SEM micrographs showed the rod- or plate-like morphology of the prepared complexes. The complexes showed promising antioxidant activity in the DPPH radical scavenging method, with an IC₅₀ value of 12–15 μg/mL. Against gram-positive and gram-negative bacteria, as well as fungi, the metal complexes also demonstrated significant antimicrobial activity. In the brine shrimp lethality bioassay, the metal complexes exhibited significantly highest cytotoxicity with the range of 15.25–24.57 μg/mL. All the complexes showed cytotoxicity against human cervical carcinoma HeLa cell lines, while the ligand itself did not show any cytotoxicity to these cancer cells. Furthermore, the metal complexes exhibited improved central and peripheral analgesic activity compared to tolfenamic acid.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Facile and Safe Route to Fabricate Boscalid-Loaded ZIF-8 Nanoparticles With Efficient Antibacterial Activity and Long-Sustained Release","authors":"Weiyan Chen,&nbsp;Jinxi Liu,&nbsp;Yingyu Zhan,&nbsp;Minghui Gao,&nbsp;Baohua Zhang","doi":"10.1002/aoc.7775","DOIUrl":"https://doi.org/10.1002/aoc.7775","url":null,"abstract":"<div>\u0000 \u0000 <p>Synthesis of ZIF-8 mainly uses zinc nitrate hexahydrate (Zn(NO₃)₂.6H₂O) as the zinc source. Zn (NO₃)₂.6H₂O is flammable, explosive, and highly corrosive, posing a threat to human health. It also requires a molar ratio of 2-methylimidazole to zinc source greater than 20, resulting in increased costs. In this work, a pH-sensitive controlled-release nano-capsule of fungicide, ZIF-8@Boscalid, was established using green zinc sources (zinc sulfate and zinc acetate) and was prepared based on metal–organic framework (ZIF-8) for higher antifungal effect and low bio-toxicity. The loading ratio is as high as 34%. In addition, the release of fungicide Boscalid showed pH-sensitive response due to the weak acidic group in the ZIF structure, in which the rate of release was more rapid under acid condition (&lt; 5). Cumulative release rates of the ZIF-8(A)@Boscalid system and ZIF-8(S)@Boscalid system were 76.15% and 86.22%, respectively. Meanwhile, the antifungal effect of ZIF-8@Boscalid was 1.5 times more of that commercially available product on CI-8 at the concentration of 300 mg/L, and the antibacterial activity values of the ZIF-8(A)@Boscalid system and ZIF-8(S)@Boscalid system against CJ-8 were 84.54% and 78.65%, respectively. Furthermore, the obtained ZIF-8@Boscalid system using the method described in this article exhibited certain UV resistance. Thus, this work not only proves that ZIF-8@Boscalid could be used as nanoparticles platform for smart control over CJ-8 but also has great potential effective utilization of Boscalid and achieving sustained release.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Organoruthenium(II) Complexes Containing Andrographolide-Appended Hydrazide Derivatives: Synthesis, Spectral Characterization, Anticancer Evaluation","authors":"P. Dhivakar,&nbsp;G. Kalaiarasi,&nbsp;S. Parveen,&nbsp;Nouf M. Alyami,&nbsp;Fatimah S. Alkhattaf,&nbsp;Priya Prasad","doi":"10.1002/aoc.7777","DOIUrl":"https://doi.org/10.1002/aoc.7777","url":null,"abstract":"<div>\u0000 \u0000 <p>A new set of andrographolide-appended hydrazide derivatives (<b>AFC</b>, <b>AGC</b>, and <b>ATC</b>) were prepared from the reaction of andrographolide with furan-2-carboxylic acid hydrazide (<b>AFC</b>), pyridine-3-carboxylic acid hydrazide (<b>AGC</b>), and thiophene 2-carboxylic acid hydrazide (<b>ATC</b>), and their corresponding ruthenium(II) complexes (<b>Ru-AFC</b>, <b>Ru-AGC</b>, and <b>Ru-ATC</b>) were synthesized by the direct reaction of [RuCl₂(<i>η</i>⁶-<i>p</i>-cymene)]₂ with ligands in dichloromethane under stirring condition. The compounds were analyzed by elemental analysis, IR, UV-Vis, ¹H NMR, and ESI-MS spectrometric techniques, and the obtained spectral data revealed that the ligands coordinated to Ru(II) ion through their enone oxygen and amine nitrogen. Antioxidant activities of the ligands and complexes were calculated against DPPH^•, ABTS^•+, O²⁻, and NO^• free radicals and their results were compared with standard antioxidants. The cytotoxic activity of the synthesized ligands and complexes toward A549 and HeLa cell lines was evaluated using MTT method (MTT = 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide). Among the compounds, the complex <b>Ru-AGC</b> showed better cytotoxic effect against A549 and HeLa cancer cells with IC₅₀ values of 4.75 ± 0.17 and 6.32 ± 0.26 μM, respectively. Further, the nontoxic nature of the compounds was confirmed by using human umbilical vein endothelial (HUVEC) cells. The apoptosis was inspected with AO/EB and DAPI staining methods; further, the percentages of the apoptotic and necrotic cells were determined by flow cytometry. Overall, the biological activities of our ruthenium(II)-arene complexes were found to be more potent than their parent ligands due to chelation, and among the complexes, <b>Ru-AGC</b> showed better activity due to the presence of pyridine ring in the <i>N</i>-terminal position of the ligand. The obtained results highlighted the strong possibility to develop highly active ruthenium complexes as anticancer agents.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, Structural Determination, DFT Calculation and Biological Evaluation Supported by Molecular Docking Approach of Some New Complexes Incorporating (E)-N'-(3,5-di-Tert-Butyl-2-Hydroxybenzylidene) Isonicotino Hydrazide Ligand","authors":"Eida S. Al-Farraj,&nbsp;Hamza A. Qasem,&nbsp;Mohamed Reda Aouad,&nbsp;Hessah A. Al-Abdulkarim,&nbsp;Wael H. Alsaedi,&nbsp;Muna S. Khushaim,&nbsp;Mehran Feizi-Dehnayebi,&nbsp;Khalaf Al-Ghamdi,&nbsp;Ahmed M. Abu-Dief","doi":"10.1002/aoc.7768","DOIUrl":"https://doi.org/10.1002/aoc.7768","url":null,"abstract":"<div>\u0000 \u0000 <p>The synthesis and structural analysis of complexes derived from (E)-N′-(3,5-di-<i>tert</i>-butyl-2-hydroxybenzylidene) isonicotino hydrazide (<b>ITB</b> ligand) were examined using multiple analytical techniques. These techniques included TGA, decomposition point determination, elemental analysis (CHN), spectroscopic (IR, NMR, mass spectrometry) analysis, magnetic susceptibility, conductivity, as well UV–Vis spectrum analysis, along with theoretical studies. Molar conductance values indicated that the Cd (II), Co (II), Cu (II), Ni (II), and Zn (II) complexes are non-electrolytes in fresh DMSO solutions, with conductance values ranging from 8.5 to 14.35 Ω⁻¹ cm² mol⁻¹. IR spectra suggested which the ligand coordinates through the metal ions in a tridentate fashion, utilizing the (N &amp; O) donor sites from the (CN &amp; CO &amp; C<span></span>O) groups in the hydroxybenzylidene moiety. Analytical data from solution complexation, job's method suggested a 1:1 (metal:ligand) molar ratio. The stability order of the complexes was determined as ITBCo &gt; ITBCu &gt; ITBNi &gt; ITBZn &gt; ITBCd, consistent with the stability constant (K_f) values. The pH profile indicated that the studied complexes exhibit stability upon a wide pH scale, typically between (pH = 4:10). Magnetic and electronic spectral analyses helped deduce the ligand coordination abilities and the geometric structures of the complexes. In vitro (antimicrobial &amp; anticancer) performances of the studied complexes were tested versus various (microbial strains &amp; cancer cell lines), revealing higher activity in the chelates assessed to the free (<b>ITB</b>) ligand. The antioxidant potential was also assessed using the DPPH assay. Finally, molecular docking was performed toward estimate the binding efficiency between various protein receptors and the compounds, with results aligning with the biological investigations.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supramolecular Self-Assembly of Novel Double Chloride-Bridging Trinuclear Ni(II) Mono-Salamo-Type Cluster: Experimental and Theoretical Analysis","authors":"Pei-Lin Yuan,&nbsp;Rui Chen,&nbsp;Le-Le Liu,&nbsp;Chen-Yin Ma,&nbsp;Wen-Kui Dong,&nbsp;Chu-Feng Sun","doi":"10.1002/aoc.7738","DOIUrl":"https://doi.org/10.1002/aoc.7738","url":null,"abstract":"<div>\u0000 \u0000 <p>A mono-salamo-type ligand H₂L was prepared to utilize 3-methoxysalicylaldehyde and a semi-salamo-type compound, and its novel trinuclear Ni(II) cluster with two significantly various configurations in the solid state was obtained by reaction of H₂L with Ni(II) ions. The trinuclear structure of the Ni(II) cluster was validated by x-ray technique, and Ni(II) ions exhibited hexa-coordinated twisted octahedrons. Its structural formula is [Ni₃(L)₂(<i>μ</i>_<i>2</i>-Cl)₂(EtOH)₂]. Chloride ions have also successfully double bridged to participate in coordination, and play a critical impact in the trinuclear configuration's stability and charge balance. Two solvent ethanol molecules are also participated in coordination. The coordination ratio of the ligand to the metal ion was verified to be 2:3 by UV–Vis absorption titration spectroscopy. The HOMO and LUMO energies of the frontline molecular orbitals of H₂L and the complex were analyzed by DFT calculations, and the energy gap value of the ligand H₂L was 4.29 eV, and that of the complex was 0.72 eV. The ligand combined with the metal decreased the energy gap value and produced a more active complex. Furthermore, Hirshfeld surface analysis visualizes the weak interactions of crystalline molecules, and these abundant weak interactions play an especially critical effect in the supramolecular structural self-assembling. The fluorescent researches proclaimed that the fluorescence intensity of the cluster significantly decreased compared with the ligand, suggesting that this ligand and complex have greater promise for fluorescence sensing.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, Structural Investigations, and Potential Antimicrobial and Anticancer Activity of Mononuclear Zn(II) and Cd(II) Complexes Decorated by Morpholine/Pyrazole s-Triazine Ligand","authors":"Shaimaa I. Gad,&nbsp;Mezna Saleh Altowyan,&nbsp;Morsy A. M. Abu-Youssef,&nbsp;Ayman El-Faham,&nbsp;Assem Barakat,&nbsp;Rajendhraprasad Tatikonda,&nbsp;Matti Haukka,&nbsp;Saied M. Soliman,&nbsp;Amal Yousri","doi":"10.1002/aoc.7772","DOIUrl":"https://doi.org/10.1002/aoc.7772","url":null,"abstract":"<div>\u0000 \u0000 <p>The structure and biological diversities of [Zn(BPT^Morph)(H₂O)₃](ClO₄)₂ (<b>1</b>), [Zn(BPT^Morph)(NO₃)₂] (<b>2</b>), and [Cd(BPT^Morph)(NO₃)₂] (<b>3</b>) complexes were described. In all complexes, the Zn(II) and Cd(II) ions are coordinated with one 4-(4,6-<i>bis</i>(3,5-dimethyl-1<i>H</i>-pyrazol-1-yl)-1,3,5-triazin-2-yl)morpholine (<b>BPT</b>^<b>Morph</b>) molecule as a pincer <i>NNN</i>-chelate. The rest of the coordination sphere was found to depend on the type of anion. In <b>1</b>, there are three coordinated water molecules leading to a distorted octahedral geometry around Zn(II). In <b>2</b> and <b>3</b>, there are two coordinated NO₃⁻ groups that differ in their coordination modes. The two NO₃⁻ groups are monodentate in <b>1</b> and bidentate in <b>3</b>. Hence, the coordination numbers of Zn(II) and Cd(II) are 5 and 7, respectively. Supramolecular structure investigations indicated the importance of O···H contacts in the molecular packing. The percentages of O···H contacts are 35.4%–36.1%, 44.8%, and 39.7% in complexes <b>1</b>–<b>3</b>, respectively. The energy breakdown for the intermolecular interactions was performed using energy framework analysis to explore the forces that dominate these interactions. Anticancer activity of complexes <b>1</b>–<b>3</b> and <b>BPT</b>^<b>Morph</b> against HepG-2, MCF-7, and A-549 cancerous cells was presented. The best result is found for complex <b>3</b> against A-549 where the IC₅₀ is 2.77 ± 0.26 μg/mL and selectivity index is 12.5 although the corresponding values for <b>BPT</b>^<b>Morph</b> are 32.39 ± 2.82 μg/mL and 2.7, respectively. In addition, <b>3</b> outperformed the anticancer drug <i>cis</i>-platin against all cell lines. The antimicrobial activity of <b>3</b> is the best compared to <b>1</b>, <b>2</b>, and <b>BPT</b>^<b>Morph</b>. Interestingly, <b>3</b> showed antibacterial efficiency comparable to gentamycin against <i>Proteus vulgaris</i>.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytotoxic Studies on Hybrid Inorganic Organic Hydrazone Metal (II) Complexes: Synthesis and Characterization of Geminal Multisite Assembly on Cyclotriphosphazene","authors":"Dinesh Kumar Chelike,&nbsp;Muhammad Sadiq,&nbsp;B. Abinash,&nbsp;Ananthan Alagumalai,&nbsp;Koustav Sarkar,&nbsp;Senthil A. Gurusamy Thangavelu","doi":"10.1002/aoc.7767","DOIUrl":"https://doi.org/10.1002/aoc.7767","url":null,"abstract":"<div>\u0000 \u0000 <p>Herein, a new hybrid inorganic–organic ligand was designed and synthesized to form a series of transition metal (II) complexes as potential substrate towards cytotoxicity studies. The inorganic heterocycle, cyclotriphosphazene (N₃P₃Cl₆, CTP) was chosen as the core unit to synthesize geminal hydrazone Schiff bases as multisite coordination ligand via substitution of six reactive chlorine. Herein, CTP was substituted by nucleophilic reaction at six chlorine atoms that exist on three phosphorus (V) centers of CTP with salicylaldehyde to form hexakis salicylaldehyde derivative. Further, salicylic hydrazide tethered with terminal amine group was condensed with above hexakis salicylaldehyde derivative of CTP at ratio of 1:6 afforded SBCTP ligand. Indeed, a series of M (II) complexes (M = Co, Ni, Mn, Cu and Zn) were obtained from SBCTP ligand with characteristic functional groups to manifest the cytotoxic activity, in order to venture as the active anticancer agent in pharmaceutics. Despite the Schiff base of aromatic rings tend to exhibit inherent cytotoxic properties, the complementary influence of CTP appended with two consecutive salicylic units in SBCTP found to show unique properties. In particular, metal (II) complexes via imine bonds of SBCTP oriented from CTP ring found to reveal essential properties to treat cancerous cells. The above ligand and prospective metal complexes were investigated individually for the cytotoxic activity with normal and cancerous cells at five different concentrations, with/without addition of the above samples into MTT assay. Structural characterization of above samples was conducted by multinuclear NMR, ¹H, ¹³C, and ³¹P as well as ESI, HRMS, FTIR, EDS, and TGA data.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of L-Ligands in Silica-Supported Ti Oxo/Imido Heterometathesis Catalysts","authors":"Nikolai S. Bushkov,&nbsp;Andrey V. Rumyantsev,&nbsp;Andrey V. Pichugov,&nbsp;Anton A. Zhizhin,&nbsp;Dmitry Yu. Aleshin,&nbsp;Evgenii I. Gutsul,&nbsp;Rina U. Takazova,&nbsp;Dinara Kh. Kitaeva,&nbsp;Fedor M. Dolgushin,&nbsp;Roman A. Novikov,&nbsp;Pavel A. Zhizhko,&nbsp;Dmitry N. Zarubin","doi":"10.1002/aoc.7746","DOIUrl":"https://doi.org/10.1002/aoc.7746","url":null,"abstract":"<div>\u0000 \u0000 <p>We report here the preparation and characterization of new well-defined silica-supported Ti imido complexes that present an L-ligand variation in a structure of currently the most active oxo/imido heterometathesis catalyst (≡SiO)Ti(=N<i>t</i>Bu)(Me₂Pyr)(py)₂ (<b>1s</b>), where py is replaced with stronger electron-donating 4-(<i>N,N-</i>dimethylamino)pyridine (<b>2s</b>) or bidentate 2,2′-bipyridine (<b>3s</b>). The materials were characterized with elemental and mass balance analyses and IR and solid-state NMR that confirmed the selective formation of surface Ti species with terminal imido ligand. Evaluation of the catalytic oxo/imido heterometathesis activity of the obtained materials demonstrated that L-ligands have a pronounced influence on the catalytic performance. In particular, the replacement of pyridine with stronger donating ligands resulted in a significant drop of activity. The catalytic results are discussed in view of the reaction mechanism and implications for further catalyst development.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"38 12","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142596220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticancer, Antihaemolytic and Anticoagulant Studies of Coumarin-Substituted Sterically Tuned N-Heterocyclic Carbene Silver(I) Complexes","authors":"Ilavarasan Vickraman,&nbsp;Vaishnavi Shashidhara,&nbsp;Thrilokraj R.,&nbsp;Jan Grzegorz Małecki,&nbsp;Madhavarani Alwarsamy,&nbsp;Kavina Ganapathy,&nbsp;Rangappa S. Keri,&nbsp;Srinivasa Budagumpi","doi":"10.1002/aoc.7784","DOIUrl":"https://doi.org/10.1002/aoc.7784","url":null,"abstract":"<div>\u0000 \u0000 <p>A series of sterically varied silver-based <i>N</i>-heterocyclic carbene (NHC) complexes (<b>14</b>–<b>17</b>) were synthesized by embroidering biomedically active coumarin and 1,2,4-triazole core as NHC precursors (<b>10</b>–<b>13</b>). The structure of all the synthesized salts (<b>10</b>–<b>13</b>) and complexes (<b>14</b>–<b>17</b>) were elucidated by FT-IR and NMR (proton and carbon) spectroscopic techniques. Complex <b>15</b> was characterized by single-crystal x-ray diffraction. The data obtained from this characterization of the small molecule <b>15</b> confirmed the three-dimensional arrangement of the complex. This also indicated agostic-type interactions between the Ag atom and the CH modules of one of the NHC ligands. Further, the synthesized complexes (<b>14</b>–<b>17</b>) were studied for the antihaemolytic, anticoagulant and anticancer activities. The complexes <b>15</b> and <b>17</b> exhibited anticoagulant properties comparable to that of the standard anticoagulant EDTA. Notably, all the complexes evidenced anticancer activity on leukaemic cell lines (K562) with the IC₅₀ values below 100 μM, the concentration at which antihaemolytic property was evidenced. Complex <b>15</b> exhibited the lowest IC₅₀ value of 18.44 ± 0.76 μM, which could be attributed by the appropriate steric bulk around the metal atom. The cumulative data of the three analyses validate potential of the complexes <b>15</b> and <b>17</b> to exhibit antihaemolytic, anticancer and anticoagulant properties.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Size-Matched Composite (CTA)3PW4@UiO-67 for the Ultra-Deep Desulfurization of Simulated Diesel: Design, Performance, and Reusability","authors":"Yan Gao,&nbsp;Shumin Zhao,&nbsp;Jingwen Huang,&nbsp;Tao Han,&nbsp;Jianshe Zhao","doi":"10.1002/aoc.7774","DOIUrl":"https://doi.org/10.1002/aoc.7774","url":null,"abstract":"<div>\u0000 \u0000 <p>Venturello-structured polyoxometalates (POMs) are effective homogeneous catalysts and confining POMs to size-matched metal-organic frameworks (MOFs) as heterogeneous catalyst is an effective way to improve their practical application. The appropriate pore and narrow window of pristine UiO-67 can not only enclose POMs in single molecule but also limit their leaching and can provide a suitable platform for the oxidation of most sulfur-containing organic compound. The composite (CTA)₃PW₄@UiO-67 was prepared by a facile in situ synthesis method, characterized by a variety of means and tested for desulfurization of multicomponent simulated diesel. The results prove that the active component (CTA)₃PW₄ is effectively encapsulated, and the composite (CTA)₃PW₄@UiO-67 show remarkable desulfurization activity and excellent reusability. In addition, the kinetics and possible mechanism of the reaction were investigated. This work opens up a new idea for the design of “host-guest adapted” catalyst suitable for fuel desulfurization technology.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}