羟基工程增强Fe3+识别的天然芦丁AIE探针

IF 3.7 2区 化学 Q2 CHEMISTRY, APPLIED
Kai Wang, Peiwen Lv, Mingyang Liu, Yunjun Mei, Yifan Zhang, Yuqiu Zheng, Jintao Guan
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引用次数: 0

摘要

传统荧光探针面临的挑战包括聚集诱导猝灭、生物不相容性和次优选择性。在这项研究中,我们开发了一种来自天然芦丁的新型探针,具有聚集诱导发射(AIE)效应。通过对芦丁的羟基工程,优化后的探针可以通过2:1的化学计量配位精确检测Fe3+。该探针具有良好的分析性能,检测限低至0.22 μM。在0 ~ 20 μM范围内观察到浓度相关的响应,在0 ~ 10 μM范围内呈显著的线性关系(R2 > 0.99)。密度泛函理论计算表明,Fe3+的结合有效地抑制了分子内电荷转移。羟基修饰在促进络合形成键和提供适当的空间位阻方面起着关键作用。本研究为基于天然产物的AIE探针建立了新的基准,加深了对类黄酮-金属识别的构效关系的认识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Natural Rutin-Based AIE Probes With Enhanced Fe3+ Recognition via Hydroxyl Group Engineering

Natural Rutin-Based AIE Probes With Enhanced Fe3+ Recognition via Hydroxyl Group Engineering

Traditional fluorescent probes have challenges, including aggregation-induced quenching, biological incompatibility, and suboptimal selectivity. In this study, we developed a novel probe derived from natural rutin featuring an aggregation-induced emission (AIE) effect. Through hydroxy engineering of rutin, the optimized probe enables precise detection of Fe3+ via 2:1 stoichiometric coordination. The probe demonstrates remarkable analytical performance, with a detection limit as low as 0.22 μM. Concentration-dependent responses were observed within 0–20 μM, with significant linearity (R2 > 0.99) in the 0–10 μM range. Density functional theory calculations reveal that the binding of Fe3+ effectively suppresses intramolecular charge transfer. The hydroxy-engineered modification plays a pivotal role in facilitating complexation for bond formation and providing appropriate steric hindrance. This research establishes a new benchmark for natural product-based AIE probes and deepens understanding of the structure–activity relationships governing flavonoid-metal recognition.

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来源期刊
Applied Organometallic Chemistry
Applied Organometallic Chemistry 化学-无机化学与核化学
CiteScore
7.80
自引率
10.30%
发文量
408
审稿时长
2.2 months
期刊介绍: All new compounds should be satisfactorily identified and proof of their structure given according to generally accepted standards. Structural reports, such as papers exclusively dealing with synthesis and characterization, analytical techniques, or X-ray diffraction studies of metal-organic or organometallic compounds will not be considered. The editors reserve the right to refuse without peer review any manuscript that does not comply with the aims and scope of the journal. Applied Organometallic Chemistry publishes Full Papers, Reviews, Mini Reviews and Communications of scientific research in all areas of organometallic and metal-organic chemistry involving main group metals, transition metals, lanthanides and actinides. All contributions should contain an explicit application of novel compounds, for instance in materials science, nano science, catalysis, chemical vapour deposition, metal-mediated organic synthesis, polymers, bio-organometallics, metallo-therapy, metallo-diagnostics and medicine. Reviews of books covering aspects of the fields of focus are also published.
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