Applied Organometallic Chemistry最新文献

{"title":"Structural and Functional Studies of Rare-Earth Complexes With 4-Methylbenzoic Acid and Terpyridine Ligands","authors":"Ruo-Bing Zhou,&nbsp;Jin-Jin Zhao,&nbsp;Ning Ren,&nbsp;Zhan-Hui Zhang,&nbsp;Jian-Jun Zhang","doi":"10.1002/aoc.70317","DOIUrl":"https://doi.org/10.1002/aoc.70317","url":null,"abstract":"<div>\u0000 \u0000 <p>This study successfully synthesized four rare-earth complexes (Tb, Er, Ho, and Nd) using 4-methylbenzoic acid (4-MHBA) and 2,2′:6′,2″-terpyridine (terpy) as ligands. Single-crystal X-ray diffraction analysis revealed that all four complexes possess identical binuclear structural features, with crystallographic data confirming their highly consistent space groups and coordination configurations. Structural purity and isostructural characteristics were further verified through complementary characterization techniques including infrared spectroscopy (IR), Raman spectroscopy, and powder X-ray diffraction (PXRD). In this work, thermogravimetric-differential scanning calorimetric technique (TG-DTG-DSC) in combination with its Fourier transformation infrared spectrometry/mass spectrum (FTIR/MS) was used to examine the thermal degradation behaviors of the complexes in a systematic manner. Results demonstrate that the complexes undergo multistage decomposition upon heating, accompanied by the release of characteristic gaseous products. Special emphasis was placed on investigating the luminescent properties of the Tb complex. Under UV excitation, this complex exhibited distinct Tb³⁺ characteristic emission peak wavelengths of 490 and 545 nm, as well as 585 and 620 nm, primarily resulting from the ligand-sensitized “antenna effect.” Fluorescence lifetime confirmed the excellent luminescent performance of this complex.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 8","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144695849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highly Selective Aldol Condensation of Furfural and Acetone Over Defective-Engineered MIL-88B Metal–Organic Frameworks","authors":"Gustavo F. Bitencourt,&nbsp;Sancler Vasconcelos,&nbsp;Luana S. Andrade,&nbsp;Vinicius Rossa,&nbsp;Daniel G. S. Quattrociocchi,&nbsp;Wagner A. Carvalho,&nbsp;Mohamad El Roz,&nbsp;Dalmo Mandelli,&nbsp;Thiago M. Lima","doi":"10.1002/aoc.70308","DOIUrl":"https://doi.org/10.1002/aoc.70308","url":null,"abstract":"<p>Furfural (FUR), a valuable platform molecule derived from lignocellulosic biomass, is a promising feedstock for producing furfural acetone (FAc) through aldol condensation reactions, offering pathways to various chemical products. However, identifying efficient and sustainable catalysts for FAc production remains challenging. Here, we introduce a novel strategy employing Fe-MIL-88B and Fe-MIL-88B-NH₂ metal–organic frameworks (MOFs) composed of nonnoble metals designed to enhance catalytic efficiency in FUR conversion. In contrast to conventional synthesis methods, our approach integrates magnetic stirring during solvothermal synthesis, promoting defect formation that improves the structural and catalytic properties of the MOFs without requiring additional reagents. Extensive characterization confirmed these structural improvements, while a statistical design of experiments guided the optimization of catalytic parameters for the FUR-acetone reaction. Thermal pretreatment emerged as a critical factor in driving high FAc selectivity. Catalytic tests showed that MOFs synthesized with stirring exhibited significantly greater selectivity than those synthesized without stirring. Furthermore, functionalization with amino groups (-NH₂) reduced FUR conversion. The optimized catalyst, Fe-MIL-88B-s, achieved a remarkable 99.4% conversion and 99.9% selectivity for FAc, demonstrating stability across three cycles. This work provides a sustainable approach to catalyzing furanic conversions using defect-engineered, nonnoble metal MOFs. It underscores the potential of simplified, scalable methods for defect induction to expand MOF applications in sustainable chemical transformations.</p>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 8","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aoc.70308","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of Sodium Alginate-Cl-Poly-(N,N′-Dimethyl Acrylamide)@Pd/Reduced Graphene Oxide Nanocomposite Hydrogel and Its Application for the Dye and Pesticide Removal From Their Aqueous Solutions","authors":"Santu Kumar Samanta,&nbsp;Rakesh Kumar Saren,&nbsp;Shubhadeep Adak,&nbsp;Tridib Tripathy","doi":"10.1002/aoc.70314","DOIUrl":"https://doi.org/10.1002/aoc.70314","url":null,"abstract":"<div>\u0000 \u0000 <p>Sodium alginate (SA) cross-linked-poly-(<i>N</i>,<i>N</i>′-dimethyl acrylamide)@Pd/reduced graphene oxide nanocomposite hydrogel (SNCHG@Pd/RGO) is prepared by using sodium alginate cross-linked poly(<i>N</i>,<i>N</i>′-dimethyl acrylamide)/reduced graphene oxide (SNCHG@RGO) with PdCl₂ in aqueous medium. SNCHG@RGO is first prepared by reducing graphene oxide (GO) with SA, followed by a cross-linked graft copolymerization reaction with <i>N</i>,<i>N</i>′-dimethyl acrylamide (DMA) in the presence of <i>N</i>,<i>N</i>′-methylenebisacrylamide (MBA) as a cross-linker and K₂S₂O₈ as the radical initiator in situ. One other nanocomposite hydrogel, sodium alginate-Cl-poly-(<i>N</i>,<i>N</i>′-dimethyl acrylamide)@Pd (SNCHG@Pd), is also prepared separately. The nanocomposite hydrogels are characterized by FTIR spectroscopy, PXRD, FESEM, EDAX, BET and TGA. The water swelling behaviour of the three synthetic nanocomposite hydrogels is evaluated. The so-prepared hydrogels are used for the adsorption studies from the aqueous solutions of a textile dye, namely, rhodamine 6G (RH), and a pesticide, namely, dimethoate (DM). Among the three nanocomposite hydrogels, SNCHG@Pd/RGO shows superior water swelling behaviour (835% at pH = 5) and also the adsorption efficiency in comparison to the other two. The order of adsorption is SNCHG@Pd/RGO &gt; SNCHG@Pd &gt; SNCHG@RGO in both cases. The adsorption of dye and pesticide by the SNCHG@Pd/RGO follows pseudo-second-order kinetics and both Dubinin–Radushkevich isotherm model and Freundlich isotherm model with Q_max values of 1265.82 mg g⁻¹ for RH at pH = 6 and 833.33 mg g⁻¹ at pH = 4 for DM, respectively. The spontaneity of the adsorption process is confirmed by the negative ΔG value.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 8","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144681283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metal–Organic Framework (MOF)-Derived Mn2O3@C for Sustainable Hydrogen Generation and Antibacterial Efficacy Against Human Pathogenic Bacteria","authors":"Mohamed N. Goda,&nbsp;Laila S. Alqarni,&nbsp;Mohamed Khairy,&nbsp;Babiker Y. Abdulkhair,&nbsp;Ghada Abd-Elmonsef Mahmoud","doi":"10.1002/aoc.70326","DOIUrl":"https://doi.org/10.1002/aoc.70326","url":null,"abstract":"<div>\u0000 \u0000 <p>Hydrogen gas has been regarded as one of the most promising energy sources. Hydrolysis of hydrides is one of the methods for producing hydrogen that has been documented. However, efficient catalysts are necessary to increase the rate at which hydrogen is generated. In the current investigation, Mn₂O₃@C derived from metal–organic framework (MOF) was used, for the first time, as an efficient catalyst for the green generation of H₂—a clean and sustainable fuel—from the hydrolysis of NaBH₄. In addition, the biological performances of this nanocatalyst towards six types of human pathogenic bacteria were also tested. Mn₂O₃@C was fabricated from the carbonization of manganese(II) benzene-dicarboxylate metal–organic frameworks (Mn-BDC). The fabricated catalyst was characterized by XRD, XPS, FTIR, HRTEM, and nitrogen sorption analyses. XRD and XPS analyses confirmed the successful formation of Mn₂O₃@C at a calcination temperature of 400 °C. Results revealed that, at a reaction temperature of 28 °C, Mn₂O₃@C offers values of hydrogen generation rate (HGR) of 150, 352, 555, 885, and 1250 mL min⁻¹ g⁻¹ corresponding to weight of NaBH₄ of 0.19, 0.3, 0.5, 0.7, and 1.0 g, respectively. Furthermore, the catalytic performance is significantly influenced by the reaction temperature; where at 28, 35, 40, and 50 °C, respectively, HGR values of 885, 1150, 1667, and 2857 mL min⁻¹ g⁻¹ were achieved. According to the pseudo-first-order equation, Mn₂O₃@C has an estimated apparent activation energy of 41.5 kJ mol⁻¹. Moreover, thermodynamic calculations showed that borohydride hydrolyzes over Mn₂O₃@C in an endothermic, entropy-driven, and spontaneous manner. The antibacterial properties of Mn₂O₃@C NPs were tested against six pathogenic bacteria: <i>Escherichia coli</i>, <i>Klebsiella pneumoniae</i>, <i>Serratia plymuthica</i>, <i>Bacillus cereus</i>, <i>B. subtilis</i>, and <i>Staphylococcus aureus</i>. Mn₂O₃@C NPs showed high antibacterial properties, especially at 150 μg mL⁻¹ concentration, with growth inhibition of 82.3%, 73.8%, 72.7%, and 71.8% of <i>S. aureus</i>, <i>E. coli</i>, <i>B. subtilis</i>, and <i>B. cereus</i>, compared with 67%, 58.2%, 56.6%, and 61.4% of chloramphenicol, respectively.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 8","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144681286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Copper(II) Complexes of Pyrazino [2,3-F][1,10]Phenanthroline Induce Cuprotosis and Immunogenic Cell Death in Triple-Negative Breast Cancer","authors":"Dongdong Li,&nbsp;Hui Wang,&nbsp;Linlin Dai,&nbsp;Cheng Tan,&nbsp;Shuang Zhi,&nbsp;Zibo Yang","doi":"10.1002/aoc.70324","DOIUrl":"https://doi.org/10.1002/aoc.70324","url":null,"abstract":"<div>\u0000 \u0000 <p>Recently, cuproptosis has garnered tremendous attention in the field of cancer therapy. However, its effectiveness remains limited by the inadequate delivery efficiency of copper ion carriers. In this regard, we have synthesized and characterized four copper(II) complexes of pyrazino [2,3-f][1,10]phenanthroline. They demonstrated significant inhibitory effects on the proliferation of the selected cell lines. In particular, <b>4</b> exhibited more prominent inhibitory effects on the growth of TNBC cells CAL-51, MDA-MB-231, and MDA-MB-468, with IC₅₀ concentrations ranging from 0.52 to 1.56 μM. It disrupted mitochondrial function in tumor cells, promoted the aggregation of DLAT, and decreased the expression levels of the key proteins FDX1, DLAT, and LIAS involved in cuproptosis. Notably, <b>4</b> not only induces cuproptosis but also triggers immunogenic cell death, often marked by the release of damage-associated molecular patterns (DAMPs), such as calreticulin (CRT) and high mobility group box 1 protein (HMGB1). Our study offers a promising approach for cancer therapy based on cuproptosis.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 8","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144681313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Copper PN(H)N Complexes: Synthesis of Pincer and Dinuclear Architectures and Base-Free C (sp3)-H Amidation Catalyzed by the Dinuclear Complex","authors":"Gazal Sabharwal,&nbsp;Khilesh C. Dwivedi,&nbsp;Maravanji S. Balakrishna","doi":"10.1002/aoc.70322","DOIUrl":"https://doi.org/10.1002/aoc.70322","url":null,"abstract":"<div>\u0000 \u0000 <p>An amide-pyridine-monophosphine ligand, {(<i>o</i>-PPh₂)C₆H₄C(O)N(H)CH₂(C₅H₄N)} (<b>1</b>), was employed for the synthesis of Cu^I and Cu^II complexes. Reaction of ligand <b>1</b> with CuX (X = Cl, Br, I) in 1:1 molar ratio afforded bidentate dinuclear P,N-chelated Cu^I complexes of the type [(CuX)₂{(<i>o</i>-PPh₂)C₆H₄C(O)N(H)CH₂(C₅H₄N)}₂-κ²-<i>P,N</i>] (<b>2</b>–<b>4</b>; X = Cl, Br, I). In contrast, treatment of <b>1</b> with CuCl₂ under aerobic conditions in a CH₂Cl₂/CH₃CN (1:1) mixture yielded the tridentate mononuclear pincer complex {CuCl₂(<i>o</i>-OPPh₂)C₆H₄C(O)N(H)CH₂(C₅H₄N)-κ³<i>-O,N,N</i>} (<b>5</b>), while reaction with CuCl in a C₂H₄Cl₂/CH₃CN (1:1) solvent system gave the dinuclear analogue [(CuCl)₂{{(<i>o</i>-OPPh₂)C₆H₄}C(O)NCH₂(C₅H₄N)}₂-κ³-<i>O,N,N</i>] (<b>6</b>). Notably, the Cu^I dinuclear complex <b>4</b> catalyzed acid and base free direct amidation of unactivated alkanes and toluene derivatives via C (<i>sp</i>^<i>3</i>)-N bond formation. This transformation proceeded efficiently through N-alkylation of phthalimide, sulfonamide, and benzamide, as well as activation of challenging C (<i>sp</i>^<i>3</i>)-H bonds in cycloalkanes, alkenes, and benzylic substrates. The catalyst exhibited high activity at low loading, delivering excellent yields under mild conditions within short reaction times.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 8","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144681392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ruthenium(II)-Arene Complexes Containing Aryl-Isatin Schiff Bases and Their Effects on Colon Cancer Cell Lines","authors":"Aslıhan Karaer Tunçay,&nbsp;Yonca Gungor,&nbsp;Hande Karabıyık,&nbsp;Hulya Ayar Kayali,&nbsp;Hayati Türkmen","doi":"10.1002/aoc.70320","DOIUrl":"https://doi.org/10.1002/aoc.70320","url":null,"abstract":"<p>Colorectal cancer is the third most commonly diagnosed cancer worldwide. Although common treatment options, such as platinum-based chemotherapeutics, initially demonstrate efficacy, their use is limited due to extreme side effects, development of chemoresistance, and a high rate of tumor recurrence. This underscores the need for the development of more effective cancer therapeutics with lower side effects. Recently, ruthenium-based compounds have emerged as promising alternatives, as they exhibit reduced cytotoxicity against healthy cells while selectively gaining cytotoxic properties against cancer cells in hypoxic conditions. In this study, we demonstrate the anticancer activities of isatin Schiff bases, including a series of aryl-isatin Schiff base ruthenium(II)-arene complex derivatives denoted <b>Ru1–3</b>, which exhibit coordination with nitrogen and oxygen donor atoms. Among those<b>, Ru1</b> complex exhibited cytotoxic activity against SW620, Caco-2, and CCD-18Co cell lines with the IC₅₀ values of 5.36 ± 1.09, 9.64 ± 2.57, and 11.04 ± 4.08, respectively. <b>Ru1</b> complex exhibited strong binding affinity of 5.14 × 10⁶ M⁻¹, and the DNA interaction studies showed intercalation between complex and DNA. Complex <b>Ru2</b> was analyzed using x-ray crystallography. This major expansion of ruthenium-based Schiff base complexes highlights the importance of ligand design and demonstrates potent cytotoxic activity against colon cancer cells.</p>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 8","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aoc.70320","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144681314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibacterial and Antifungal Activities of Pterocarya fraxinifolia Extract Encapsulated in ZIF-8","authors":"Parisa Ghazanfari,&nbsp;Mohsen Nori,&nbsp;Milad Arab-Nozari,&nbsp;Seyed Meysam Baghbanian,&nbsp;Seyed Mohammad Vahdat","doi":"10.1002/aoc.70315","DOIUrl":"https://doi.org/10.1002/aoc.70315","url":null,"abstract":"<div>\u0000 \u0000 <p>Antibiotic resistance is an escalating global threat, prompting the urgent need for alternative antimicrobial strategies. In this study, a novel nanocomposite was developed by encapsulating <i>Pterocarya fraxinifolia</i> leaf extract (PF) into a zeolitic imidazolate framework-8 (ZIF-8), aiming to enhance its stability and antimicrobial efficacy. The synthesized PF@ZIF-8 composite was characterized using FTIR, XRD, BET, and SEM analyses, confirming successful encapsulation and preserved structural integrity. The antimicrobial activity of PF@ZIF-8 was evaluated against <i>Candida albicans</i>, <i>Aspergillus flavus</i>, <i>Staphylococcus aureus</i>, and <i>Escherichia coli</i> using well and disk diffusion methods. Compared to the free extract and ZIF-8 alone, the PF@ZIF-8 nanocomposite—particularly at 20% extract loading—demonstrated significantly larger inhibition zones and lower minimum inhibitory concentration (MIC) values. Notably, the nanocomposite showed superior performance against <i>C. albicans</i> and <i>E. coli</i>, suggesting selective and enhanced antimicrobial behavior. The improved efficacy is attributed to the sustained release and structural protection provided by the ZIF-8 matrix, along with potential synergism between Zn²⁺ ions and plant-derived phytochemicals. While cytotoxicity data were not included in this study, the natural origin of PF and the biocompatible nature of ZIF-8 highlight the potential for biomedical applications. These findings suggest that PF@ZIF-8 offers a promising green antimicrobial platform for combating resistant pathogens.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 8","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144681459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and Quantum Chemical Calculations of Nano-Sized Metal (III/II) Complexes of Furan-Based Schiff Base for Promising Therapeutic Studies: Interaction With Biomolecules, Antioxidant Activity, in Vitro Cytotoxicity, Apoptotic Activity, and Cell Cycle Analysis","authors":"Hind Ahmed Siddiq,&nbsp;Nada D. Alkhathami,&nbsp;Abeer A. Ageeli,&nbsp;Ibtisam Mousa,&nbsp;Deemah Mizher Alenazy,&nbsp;Nada M. Alatawi,&nbsp;Abdel-Nasser M. A. Alaghaz","doi":"10.1002/aoc.70297","DOIUrl":"https://doi.org/10.1002/aoc.70297","url":null,"abstract":"<div>\u0000 \u0000 <p>A new six-novel tetradentate ligand, [N, N′-(1,2-phenylene)bis(1-(5-(2-fluorophenyl)furan-2-yl)methanimine)) nano-sized metal complexes [Cr (III) <b>(C1)</b>, Fe (III)<b>(C2)</b>, Co (II)<b>(C3)</b>, Ni (II)<b>(C4)</b>, Cu (II)<b>(C5)</b>, and Cd (II)<b>(C6)</b>] were synthesized. The complexes were characterized using analytical methods and diverse spectroscopic tools. The spectral data of the metal (III/II) complexes suggest that the ligand coordinates as a tetradentate agent through two imine nitrogen (N) atoms and two furan oxygen (O) atoms. The octahedral <b>(C1–C6)</b> was the suggested geometry for the complexes. The present study has discussed the computational details of the theoretical calculations (DFT) of the complexes. Theoretical optimization employing the density functional theory (DFT) was accomplished on the molecular structures of the compounds in question. The TEM, XRD, and AFM of the studied complexes unveiled distinct and strong diffraction peaks, signifying their crystalline nature, and providing evidence of their particle sizes being within the nano-size. The chemical nuclease activities of the complexes have been explored by using UV–Vis and viscosity quantification techniques. The in vitro anticancer activity of the compounds was evaluated against MCF7, HCT-116, and HepG-2 cell lines. Among all the complexes, it was revealed that complex <b>C6</b> was the most potent and least toxic against HepG-2 cell lines based on IC₅₀ and selective indices (SI) values. Further research showed that complex <b>C6</b> could also induce G2 and S-phase cell cycle arrest.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 8","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144681264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functionalized Gum Acacia Hydrogels With Silver Nanoparticles for Enhanced Antimicrobial and Environmental Applications","authors":"Karanpreet Virk,&nbsp;Vinod Kumar,&nbsp;Abhinav Kumar,&nbsp;Sanjeev Kumar,&nbsp;Jyoti Gaur,&nbsp;Jasvir Dalal","doi":"10.1002/aoc.70309","DOIUrl":"https://doi.org/10.1002/aoc.70309","url":null,"abstract":"<div>\u0000 \u0000 <p>In this study, we report the green synthesis of multifunctional nanocomposite hydrogels by incorporating silver nanoparticles (Ag NPs) into gum acacia (GA)-grafted poly(methacrylic acid) (GA-g-poly(MAA)) and poly(methacrylic acid-aniline) (GA-g-poly(MAA-ANI)) matrices using microwave irradiation. The synthesized nanocomposites' structural, morphological, and thermal properties were characterized using XRD, FTIR, FESEM, and TGA analyses, confirming the uniform dispersion of Ag NPs. The Ag NP content in the hydrogels was 0.17 wt% for GA-g-poly(MAA)/Ag and 0.11 wt% for GA-g-poly(MAA-Ag-ANI). They enhanced thermal stability up to 450°C. Antibacterial and antifungal activity tests demonstrated significant efficacy, with inhibition zones of 4 mm for <i>Staphylococcus aureus</i>, 3 mm for <i>Escherichia coli</i>, and 4 mm for <i>Candida albicans</i>. Minimum inhibitory concentration (MIC) values were as low as 0.5 μg/mL against <i>C. albicans</i>. The hydrogels achieved 92% methylene blue (MB) removal from a 50-ppm solution using 2 g of hydrogel in 390 min, with an adsorption capacity of 45 mg/g. These results highlight these biocompatible, eco-friendly nanocomposites' exceptional antimicrobial and dye adsorption capacity, presenting them as promising candidates for antimicrobial therapies and environmental remediation solutions. These results demonstrate the potential of nanocomposites for advanced wound dressings and efficient water treatment systems.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 8","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}