Applied Organometallic Chemistry最新文献

{"title":"The Effect of Anion, Steric Factors on the Catalytic Activity of Hydrogen Peroxide, Biological Activities, Docking, and DFT Calculations of Novel Mixed Ligand of Copper Complexes","authors":"Nelly H. Mahmoud,&nbsp;Asmaa M. Fahim","doi":"10.1002/aoc.70220","DOIUrl":"https://doi.org/10.1002/aoc.70220","url":null,"abstract":"<div>\u0000 \u0000 <p>Mixed-ligand Cu (II) complexes with the empirical formula [Cu(N-N)(Hfac)]X have been produced, where N-N represents 2,2′-Bipyridine (Bipy), 1,10-phenanthroline (Phen), or 4,7-diphenyl-1,10-phenanthroline (Diphen), HfacH denotes hexafluoroacetylacetone, and X signifies the counter ion (Cl⁻ or ClO₄⁻). Comprehensive physicochemical analyses, encompassing elemental analysis, UV–visible spectroscopy, FT-IR spectroscopy, TGA, ESR, mass spectrometry, XRD, magnetic measurements, and molar conductance assessments, have been conducted. The thermal stability of all complexes was assessed using TGA analysis, and the kinetic parameters were derived using the Coats–Redfern method. The degree of crystallinity and the unit cell of all compounds were ascertained using XRD measurements. A square planar geometric configuration is suggested for CuHfBP and CuHfPhP complexes, while octahedral or tetrahedral geometry is recommended for the other complexes. The copper mixed-ligand complexes demonstrate significant catalytic activity in the decomposition of hydrogen peroxide through a first-order process. The stability sequence of ternary complexes concerning their ligands is as follows: Bipy &gt; o-Phen &gt; Diphen. Additionally, both the ligands and all metal complexes were optimized by theoretical analysis using a DFT/B3LYP/LANL2DZ basis set to ascertain the theoretical stability of these metals and to identify FMO orbitals, TDOS, ESP, energy gap, and physical computational parameters, which indicate the stability of these complexes. Additionally, the synthesized complexes exhibited antimicrobial and antitumor activities against HNSCC cancer cell and showed that the presence of the phenyl rings makes the delocalization of electrons and increases the activities of them. Moreover, the docking stimulation of these complexes with PDBID:3HUN, 3 t88, and 3ayk showed their various binding activities and confirmed the experimental results.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 6","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144108815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, Crystal Structure, and Computational Investigation of Zinc–Cytosine Coordination Complex: Insights From Molecular Docking, ADME Prediction, HOMO-LUMO, and MEP Analysis","authors":"Karuppiah Nagaraj,&nbsp;A. Karthikeyan,&nbsp;G. Velmurugan,&nbsp;M. Muthukkumar,&nbsp;Sandhanasamy Devanesan,&nbsp;Otuokere Ifeanyi Edozie,&nbsp;S. Kamalesu,&nbsp;R. Subramanian,&nbsp;K. Raja,&nbsp;S. Rameshkumar","doi":"10.1002/aoc.70215","DOIUrl":"https://doi.org/10.1002/aoc.70215","url":null,"abstract":"<div>\u0000 \u0000 <p>In this study, a zinc–cytosine complex was synthesized by reacting zinc bromide with cytosine in a 1:2 molar ratio using propanol as the solvent. The crystalline complex dibromo-bis(cytosine)zinc(II) was structurally characterized using X-ray diffraction, confirming its molecular architecture. Molecular docking studies were conducted on three enzymes: <i>Haemophilus influenzae</i> (1GQY), <i>Yersinia pestis</i> RNA methyltransferase (3N4K), and <i>Mycobacterium tuberculosis</i> synthase (2O0D). The results revealed strong inhibitory potential against <i>M. tuberculosis</i> synthase, with hydrogen bonds formed with residues GLY 339 and significant steric interactions involving SER167 and PRO 125 hydrophobic interactions are observed with PRO 128 and ALA 166. Binding energies ranged from −6.6 kcal/mol, demonstrating robust interactions through hydrogen bonding and steric effects. The carbonyl group forms a conventional hydrogen bonding interaction with SER167 with distances of 2.21 Å. The hydrogen bonding C<span></span>H bond interaction with PRO 125 and GLY 339 with distances of 3.42 and 3.42 Å. Drug-likeness evaluations using Lipinski's Rule of Five and ADME profiling indicated favorable attributes, such as good bioavailability, water solubility, and non-inhibition of cytochrome P450 enzymes. Computational analyses, including HOMO-LUMO gap and molecular electrostatic potential mapping, highlighted high reactivity and polarizability, with an energy gap of 0.8853 eV. These findings suggest the zinc–cytosine complex as a promising candidate for further drug development research.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 6","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144108726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting the PI3K/AKT/mTOR Signaling Pathway in TCCSUP Bladder Cancer Cell by the Panax ginseng Leaf Extract Green-Synthesized Silver Nanoparticles","authors":"Hongxin Mu,&nbsp;Kanxi Zhang,&nbsp;Yaming Zhao,&nbsp;Guozhi Cheng,&nbsp;Bo Yang","doi":"10.1002/aoc.70224","DOIUrl":"https://doi.org/10.1002/aoc.70224","url":null,"abstract":"<div>\u0000 \u0000 <p>The mTOR signaling pathway has a main role in integrating extracellular and intracellular signals, acting as a key regulator of proliferation, growth, metabolism, and survival. Research conducted over the past 10 years has revealed that the mTOR pathway is activated in numerous cellular processes, including angiogenesis, tumor formation, adipogenesis, insulin resistance, and T-lymphocyte activation. Furthermore, it is dysregulated in various human diseases, including type 2 diabetes and cancer. Recently, nanoparticles (NPs) have been formulated for cancer treatment. Treatment of several cancers such as uterine cancer, lung cancer, gastric cancer, bone cancer, and glioma have been reported by the silver NPs green-synthesized by plant extracts. This study reports on the green manufacture of silver NPs utilizing <i>Panax ginseng</i> and its antibladder cancer properties that follow the PI3K-Akt-mTOR pathway. The NPs were described using UV-Vis, XRD, FE-SEM, and FT-IR. The biological aspects were the focus of a recent study. The MTT examination was used to evaluate the cytotoxic potentials of Ag NPs on HUVEC and TCCSUP cancer cells after the cells were exposed to them for 48 h. Ag NPs with a spherical shape and an appropriate average size of 43.71 nm were shown to have a crystallinity structure in the results. When exposed to Ag NPs, the cancer cell's viability diminished, resulting in an IC₅₀ value of 154 μg/mL. An mTOR pathway in-depth examination indicated that Ag NPs influence apoptosis and cell proliferation in TCCSUP through the pathway modulation. Additionally, the antioxidant evaluation showed that Ag NPs' IC₅₀ value regarding DPPH was 62 μg/mL. The pathway inhibited the cell cycle and induced the apoptosis triggered by Ag NPs. Therefore, in the treatment of bladder carcinoma, Ag NPs may prove to be a beneficial natural anticancer agent.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 6","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144108828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-Apoptotic Efficacies of Iron Nanoparticles Green-Formulated by Syzygium aromaticum Leaf Extract on NCI-H661 Human Lung Adenocarcinoma Cell Line and Following the PI3K/AKT/mTOR Signaling Pathway","authors":"Yue Li,&nbsp;Wei Tian,&nbsp;Chen Chen,&nbsp;Hailin Liu,&nbsp;Zhenfa Zhang,&nbsp;Changli Wang","doi":"10.1002/aoc.70214","DOIUrl":"https://doi.org/10.1002/aoc.70214","url":null,"abstract":"<div>\u0000 \u0000 <p>The overstimulation of the mechanistic target of the rapamycin (mTOR) signaling pathway is important for regulating cellular growth and proliferation and is frequently seen in different types of cancer. Recently, metallic nanoparticles have been used to treat many cancers. This study describes a straightforward, eco-friendly chemical investigation and a bio-inspired method for producing iron nanoparticles using leaf extract from <i>Syzygium aromaticum</i>. The iron nanoparticles were thoroughly characterized using advanced physicochemical techniques like energy dispersive X-ray (EDX), ultraviolet–visible (UV–vis) spectroscopy, Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), and field emission scanning electron microscopy (FE-SEM) analysis, and the data verified that the iron nanoparticles have a spherical morphology with an average diameter of 10 to 35 nm. The cellular and molecular elements were the main focus of the latest investigation. For 48 h, the MTT test was used to assess the cytotoxicity and antihuman lung cancer potential of the iron nanoparticle-treated cells in both HUVEC (normal) and NCI-H661 cells. When exposed to iron nanoparticles, the NCI-H661 cell line showed a dose-dependent decrease in viability, with an IC₅₀ value of 73 μg/mL. By altering the PI3K-Akt-mTOR signaling pathway, iron nanoparticles control cell death and proliferation in NCI-H661 cells, according to additional research on the mTOR pathway. Iron nanoparticle-induced cell cycle and apoptosis inhibition may be mediated by the mTOR pathway. Therefore, iron nanoparticles may be useful as a natural anticancer medication to help cure lung adenocarcinoma.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 6","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144100709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Samarium Rod-MOF With Benzophenone-4,4´-Dicarboxylate Linker: A Catalyst for Glycerol Acetalization to Solketal","authors":"Taraneh Hajiashrafi,&nbsp;Nazanin Afzali,&nbsp;Sara Tarighi,&nbsp;Hadi Amiri Rudbari,&nbsp;Olivier Blacque","doi":"10.1002/aoc.70151","DOIUrl":"https://doi.org/10.1002/aoc.70151","url":null,"abstract":"<div>\u0000 \u0000 <p>A samarium-based metal–organic framework (MOF) containing benzophenone-4,4′-dicarboxylate (bpndc) linker was synthesized and characterized using X-ray crystallography and spectroscopy methods. The crystal structure analysis revealed that the MOF is a three-dimensional 3-nodal 5-c net. The prepared MOF was used as a catalyst in glycerol acetalization to produce solketal as a fuel additive. The catalyst with suitable thermal stability and acidic characteristics resulted in 93.7% glycerol conversion with solketal selectivity of 90.1%. This study further supports the effectiveness of Ln-based MOF as potential Lewis acid catalysts for chemical transformations.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 6","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144100708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green Formulation of Ag Nanoparticles by Scrophularia striata: Introducing a Navel Chemotherapeutic Drug for the Treatment of Head and Neck Cancers","authors":"Geng Liu,&nbsp;Yiyang Min,&nbsp;Zhenxing Zhang,&nbsp;Yukang Ying,&nbsp;Liyuan Zhou,&nbsp;Tingchen Mou","doi":"10.1002/aoc.70160","DOIUrl":"https://doi.org/10.1002/aoc.70160","url":null,"abstract":"<div>\u0000 \u0000 <p>In the current study, we attempted to formulate the silver nanoparticles using <i>Scrophularia striata</i> leaf as a new chemotherapeutic drug for the head and neck cancers treatment using characterization tests such as UV–Vis, EDX, TEM, and FE-SEM for the first time. The new chemotherapeutic supplement developments with notable potential for the cancer treatment are priorities for both developed and developing nations. The MTT test was applied to the A-253, SCC-15, FaDu, and Detroit 562 cancer cell lines to check the cytotoxicity and anti-head and neck cancer properties of AgNPs. BHT was utilized as the positive control in the DPPH test to examine the AgNP antioxidant qualities. The nanoparticles had a spherical form and the size of 10–70 nm in the TEM and FE-SEM pictures. Following treatment with low quantities of AgNPs, the MTT assay findings verified the removal of the A-253, SCC-15, FaDu, and Detroit 562 cell lines. Half of the DPPH molecules were suppressed by silver nanoparticles at a dose of 45 μg/mL. As previously stated, AgNPs demonstrated strong anti-head and neck cancer effects against the aforementioned cell lines. These Ag NPs can be employed as a chemotherapeutic medication to treat head and neck tumors after the findings of the clinical trial studies have been approved.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 6","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation of Z-Type Co2SnO4/Mn0.5Cd0.5S Heterojunction for Efficient Piezo-Photocatalytic Hydrogen Production","authors":"Gang Zhao,&nbsp;Nan Li,&nbsp;Yi Wu,&nbsp;Kai Zhao,&nbsp;Wenhua Fu,&nbsp;Shirui Zhang,&nbsp;Jiangquan Ma","doi":"10.1002/aoc.70211","DOIUrl":"https://doi.org/10.1002/aoc.70211","url":null,"abstract":"<div>\u0000 \u0000 <p>Although conversion of solar-energy for catalytic water splitting into H₂ is promising technology, the sluggish charge separation in photocatalytic process severely restricts the activity. Combining the piezoelectric effect of piezoelectric materials with the load cocatalyst strategy can effectively modulate the transport behavior of carriers. Herein, a novel and efficient Co₂SnO₄ cocatalyst is loaded onto Mn_xCd_1-xS (x = 0.2, 0.3, 0.4, 0.5, 0.6, 0.7) piezoelectric material to form a heterostructure for piezo-photocatalytic hydrogen evolution. To the best of our knowledge, Co₂SnO₄ has not been reported as a cocatalyst in the field of piezoelectric photocatalysis. The 7% Co₂SnO₄/Mn_0.5Cd_0.5S (CSO/MCS) exhibits excellent piezoelectric-photocatalytic hydrogen production rate (29.86 mmol/g/h) under the condition of light coupling ultrasound, which is significantly superior to piezoelectric catalysis (128.35 μmol/g/h) and photocatalysis (9.25 mmol/g/h). The built-in electric field in Mn_0.5Cd_0.5S piezo-photocatalyst and the Z-type heterojunction made up of the tight connection of Co₂SnO₄ and Mn_0.5Cd_0.5S both promote the carrier separation efficiency, thereby improving the catalytic reaction performance. This work manifests a promising approach to design heterojunction catalysts for efficient renewable fuel production by capturing solar and mechanical energy.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 6","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AgOTf-Catalysed Regioselective C1-Amination of Pyrrolo[1,2-a]quinoxaline With Azodicarboxylates","authors":"Wanqiang Wang,&nbsp;Jing Guo,&nbsp;Di Hao,&nbsp;Yishi Guo,&nbsp;Jianshu Zhang,&nbsp;Ping Liu","doi":"10.1002/aoc.70228","DOIUrl":"https://doi.org/10.1002/aoc.70228","url":null,"abstract":"<div>\u0000 \u0000 <p>AgOTf-catalysed regioselective C1-amination of pyrrolo[1,2-<i>a</i>]quinoxaline has been developed. The reaction allowed the use of various pyrrolo[1,2-<i>a</i>]quinoxalines and azodicarboxylates as coupling partners to afford C1-aminated products with good to excellent yields. The synthetic strategy showed excellent regioselectivity, functional group tolerance as well as gram-scale synthesis. The amination products were further modified to furnish structurally diverse pyrrolo[1,2-<i>a</i>]quinoxaline compounds.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 6","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficient and Regioselective Hydrosilylation of Alkynes to (E)-β-Vinylsilanes Using Dicobalt Complexes","authors":"Danfeng Deng,&nbsp;Shuo Dong,&nbsp;Fangle Zhong,&nbsp;Yongbing Gu,&nbsp;Zefeng Wang","doi":"10.1002/aoc.70221","DOIUrl":"https://doi.org/10.1002/aoc.70221","url":null,"abstract":"<div>\u0000 \u0000 <p>Three NNOPP [R-C₅H₃N-C₅H₃N-COH-(C₆H₄-PPh₂)₂, <b>L</b>_<b>1</b>: R = OCH₃, <b>L</b>_<b>2</b>: R = H, <b>L</b>_<b>3</b>: R = CF₃] ligands are synthesized and introduced to cobalt centers. The corresponding dicobalt complexes[{R-C₅H₃N-C₅H₃N-COH-(C₆H₄-PPh₂)₂}Co₂Cl₃ (<b>1</b>: R = OCH₃, <b>2</b>: R = H, <b>3</b>: R = CF₃)], which are bench-stable, are developed, respectively. The regioselective hydrosilylations of terminal alkynes with primary silane are investigated to produce (<i>E</i>)-vinylsilanes in good yields with excellent regioselectivity, and complex <b>3</b> exhibits the highest activity.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 6","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solvent-Free Synthesis of Pd-Modified Zeolitic Imidazolate Framework Nanocomposites for Competitive Arylation and Carbon–Carbon Coupling Reactions","authors":"Alireza Pourvahabi Anbari,&nbsp;Alireza Ranjbari,&nbsp;Muhammad Kashif,&nbsp;Shima Rahmdel Delcheh,&nbsp;Tatwadhika Rangin Siddhartha,&nbsp;Serge Zhuiykov,&nbsp;Philippe M. Heynderickx,&nbsp;Francis Verpoort","doi":"10.1002/aoc.70200","DOIUrl":"https://doi.org/10.1002/aoc.70200","url":null,"abstract":"<div>\u0000 \u0000 <p>Over an extended period, identifying effective approaches for achieving versatile arylations has presented a notable synthetic challenge. In our research, we have successfully fabricated nanocomposites of zeolitic imidazole frameworks, specifically Pd-ZIF-8 and Pd-ZIF-67, using an in situ thermal (IST) approach. These compounds have exhibited high catalytic activity as heterogeneous catalysts in carbon–carbon coupling processes mediated by palladium, such as the Suzuki–Miyaura reaction (which involves aryl halides and aryl boronic acids) and the Mizoroki–Heck reaction (which involves aryl halides and olefins). In comparison to previously published research, the IST technique has a number of benefits; these features include the removal of solvents and additives, a low reaction temperature, a single-step process, no need for activation, and the use of the smallest possible precursor ratio (M/L). This accomplishment was realized through the precise control of ligands and additives.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 6","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}