超分子行为在结构不匹配Zn和co - mof的抗菌活性和抗氧化中的有效应用

IF 3.7 2区 化学 Q2 CHEMISTRY, APPLIED
Zi-hang Yuan, Si-ya Zheng, Yu-mei Dai, En Tang
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引用次数: 0

摘要

抗生素耐药性和氧化应激带来的全球挑战不断升级,迫切需要开发集抗菌和抗氧化能力于一体的双功能材料,以应对这些相互交织的生物威胁。这就提出了一个关键问题:为什么不设计一种能够同时提供抗氧化和抗菌功能的材料呢?为了弥补这一关键差距,我们通过超分子相互作用战略性地设计了两种新型Co和Zn金属有机框架(mof),以实现协同抗微生物-抗氧化性能,并通过多模态表征进行了严格验证。与传统抗生素不同,这些MOFs通过控制金属离子的释放等机制发挥抗菌作用。Co和Zn-MOFs对革兰氏阴性菌和革兰氏阳性菌均表现出强大的抗菌功效,并具有强大的抗氧化性能。zn - mof通过加强与细菌表面的疏水相互作用而增强膜破坏,从而增强抗菌活性,而co - mof由于其氧化还原活性而表现出优越的抗氧化能力。本研究揭示了金属-细菌界面动力学与细胞壁结构完整性保存之间的关键机制相互作用。这些MOFs重新定义了用于对抗耐药病原体和氧化损伤的多功能材料范例,为生物医学创新及其他领域提供了变革潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Efficient Application of Supramolecular Behavior in the Antimicrobial Activity and Antioxidant of Structurally Mismatched Zn and Co-MOFs

Efficient Application of Supramolecular Behavior in the Antimicrobial Activity and Antioxidant of Structurally Mismatched Zn and Co-MOFs

The escalating global challenges posed by antibiotic resistance and oxidative stress demand the urgent development of dual-functional materials integrating both antimicrobial and antioxidant capacities to address these intertwined biological threats. This raises a pivotal question: Why not engineer a material capable of simultaneously delivering antioxidant and antibacterial functionalities? To bridge this critical gap, we strategically designed two novel Co and Zn metal–organic frameworks (MOFs) through supramolecular interactions to achieve synergistic antimicrobial–antioxidant performance, rigorously validated via multimodal characterization. Different from traditional antibiotics, these MOFs exert antibacterial effects by controlling the release of metal ions and other mechanisms. Co and Zn-MOFs demonstrated robust antimicrobial efficacy against both Gram-negative and Gram-positive bacteria, coupled with potent antioxidant properties. Zn-MOFs exhibited enhanced antibacterial activity by intensifying membrane disruption via strengthened hydrophobic interactions with bacterial surfaces, whereas Co-MOFs showcased superior antioxidant capacity derived from their redox-active nature. This study unravels the critical mechanistic interplay between metal-bacteria interfacial dynamics and the preservation of cell wall structural integrity. These MOFs redefine multifunctional material paradigms for combating drug-resistant pathogens and oxidative damage, offering transformative potential for biomedical innovations and beyond.

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来源期刊
Applied Organometallic Chemistry
Applied Organometallic Chemistry 化学-无机化学与核化学
CiteScore
7.80
自引率
10.30%
发文量
408
审稿时长
2.2 months
期刊介绍: All new compounds should be satisfactorily identified and proof of their structure given according to generally accepted standards. Structural reports, such as papers exclusively dealing with synthesis and characterization, analytical techniques, or X-ray diffraction studies of metal-organic or organometallic compounds will not be considered. The editors reserve the right to refuse without peer review any manuscript that does not comply with the aims and scope of the journal. Applied Organometallic Chemistry publishes Full Papers, Reviews, Mini Reviews and Communications of scientific research in all areas of organometallic and metal-organic chemistry involving main group metals, transition metals, lanthanides and actinides. All contributions should contain an explicit application of novel compounds, for instance in materials science, nano science, catalysis, chemical vapour deposition, metal-mediated organic synthesis, polymers, bio-organometallics, metallo-therapy, metallo-diagnostics and medicine. Reviews of books covering aspects of the fields of focus are also published.
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