{"title":"超分子行为在结构不匹配Zn和co - mof的抗菌活性和抗氧化中的有效应用","authors":"Zi-hang Yuan, Si-ya Zheng, Yu-mei Dai, En Tang","doi":"10.1002/aoc.70363","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>The escalating global challenges posed by antibiotic resistance and oxidative stress demand the urgent development of dual-functional materials integrating both antimicrobial and antioxidant capacities to address these intertwined biological threats. This raises a pivotal question: Why not engineer a material capable of simultaneously delivering antioxidant and antibacterial functionalities? To bridge this critical gap, we strategically designed two novel Co and Zn metal–organic frameworks (MOFs) through supramolecular interactions to achieve synergistic antimicrobial–antioxidant performance, rigorously validated via multimodal characterization. Different from traditional antibiotics, these MOFs exert antibacterial effects by controlling the release of metal ions and other mechanisms. Co and Zn-MOFs demonstrated robust antimicrobial efficacy against both Gram-negative and Gram-positive bacteria, coupled with potent antioxidant properties. Zn-MOFs exhibited enhanced antibacterial activity by intensifying membrane disruption via strengthened hydrophobic interactions with bacterial surfaces, whereas Co-MOFs showcased superior antioxidant capacity derived from their redox-active nature. This study unravels the critical mechanistic interplay between metal-bacteria interfacial dynamics and the preservation of cell wall structural integrity. These MOFs redefine multifunctional material paradigms for combating drug-resistant pathogens and oxidative damage, offering transformative potential for biomedical innovations and beyond.</p>\n </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 9","pages":""},"PeriodicalIF":3.7000,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Efficient Application of Supramolecular Behavior in the Antimicrobial Activity and Antioxidant of Structurally Mismatched Zn and Co-MOFs\",\"authors\":\"Zi-hang Yuan, Si-ya Zheng, Yu-mei Dai, En Tang\",\"doi\":\"10.1002/aoc.70363\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n <p>The escalating global challenges posed by antibiotic resistance and oxidative stress demand the urgent development of dual-functional materials integrating both antimicrobial and antioxidant capacities to address these intertwined biological threats. This raises a pivotal question: Why not engineer a material capable of simultaneously delivering antioxidant and antibacterial functionalities? To bridge this critical gap, we strategically designed two novel Co and Zn metal–organic frameworks (MOFs) through supramolecular interactions to achieve synergistic antimicrobial–antioxidant performance, rigorously validated via multimodal characterization. Different from traditional antibiotics, these MOFs exert antibacterial effects by controlling the release of metal ions and other mechanisms. Co and Zn-MOFs demonstrated robust antimicrobial efficacy against both Gram-negative and Gram-positive bacteria, coupled with potent antioxidant properties. Zn-MOFs exhibited enhanced antibacterial activity by intensifying membrane disruption via strengthened hydrophobic interactions with bacterial surfaces, whereas Co-MOFs showcased superior antioxidant capacity derived from their redox-active nature. This study unravels the critical mechanistic interplay between metal-bacteria interfacial dynamics and the preservation of cell wall structural integrity. These MOFs redefine multifunctional material paradigms for combating drug-resistant pathogens and oxidative damage, offering transformative potential for biomedical innovations and beyond.</p>\\n </div>\",\"PeriodicalId\":8344,\"journal\":{\"name\":\"Applied Organometallic Chemistry\",\"volume\":\"39 9\",\"pages\":\"\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2025-08-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Applied Organometallic Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/aoc.70363\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Applied Organometallic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/aoc.70363","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
Efficient Application of Supramolecular Behavior in the Antimicrobial Activity and Antioxidant of Structurally Mismatched Zn and Co-MOFs
The escalating global challenges posed by antibiotic resistance and oxidative stress demand the urgent development of dual-functional materials integrating both antimicrobial and antioxidant capacities to address these intertwined biological threats. This raises a pivotal question: Why not engineer a material capable of simultaneously delivering antioxidant and antibacterial functionalities? To bridge this critical gap, we strategically designed two novel Co and Zn metal–organic frameworks (MOFs) through supramolecular interactions to achieve synergistic antimicrobial–antioxidant performance, rigorously validated via multimodal characterization. Different from traditional antibiotics, these MOFs exert antibacterial effects by controlling the release of metal ions and other mechanisms. Co and Zn-MOFs demonstrated robust antimicrobial efficacy against both Gram-negative and Gram-positive bacteria, coupled with potent antioxidant properties. Zn-MOFs exhibited enhanced antibacterial activity by intensifying membrane disruption via strengthened hydrophobic interactions with bacterial surfaces, whereas Co-MOFs showcased superior antioxidant capacity derived from their redox-active nature. This study unravels the critical mechanistic interplay between metal-bacteria interfacial dynamics and the preservation of cell wall structural integrity. These MOFs redefine multifunctional material paradigms for combating drug-resistant pathogens and oxidative damage, offering transformative potential for biomedical innovations and beyond.
期刊介绍:
All new compounds should be satisfactorily identified and proof of their structure given according to generally accepted standards. Structural reports, such as papers exclusively dealing with synthesis and characterization, analytical techniques, or X-ray diffraction studies of metal-organic or organometallic compounds will not be considered. The editors reserve the right to refuse without peer review any manuscript that does not comply with the aims and scope of the journal. Applied Organometallic Chemistry publishes Full Papers, Reviews, Mini Reviews and Communications of scientific research in all areas of organometallic and metal-organic chemistry involving main group metals, transition metals, lanthanides and actinides. All contributions should contain an explicit application of novel compounds, for instance in materials science, nano science, catalysis, chemical vapour deposition, metal-mediated organic synthesis, polymers, bio-organometallics, metallo-therapy, metallo-diagnostics and medicine. Reviews of books covering aspects of the fields of focus are also published.