姜黄素绿色银纳米颗粒治疗败血症后主动脉和心脏损伤

IF 3.7 2区 化学 Q2 CHEMISTRY, APPLIED
Qing Li
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引用次数: 0

摘要

姜黄的主要次生代谢产物是一种叫做姜黄素的多酚分子。根据中医的说法,这种化学物质有很多好处。然而,到目前为止,还没有研究检验其纳米颗粒在减少败血症引起的心脏和主动脉损伤方面的可能优势。因此,这项工作的目的是研究氧化应激标志物和一氧化氮(NO)在败血症诱导的主动脉和心脏损伤中如何受到由姜黄素配制的银纳米颗粒绿色的影响。本研究利用绿色配方技术表征和合成纳米银。研究人员使用了几种光谱技术来分析纳米银,并研究了它们治疗败血症引起的心脏和主动脉损伤的能力。将成年雄性Wistar大鼠分为对照组、脂多糖组和纳米银组(50和200 μg/kg,口服)。连续14 d,每天注射脂多糖(LPS)。银纳米颗粒治疗在LPS给药前3天开始,并在LPS给药期间继续进行。研究结束后评估抗氧化酶、硫醇、NO和丙二醛(MDA)水平。研究结果表明,纳米银颗粒可以通过减少NO的生成和促进氧化还原止血来预防LPS引起的心血管损伤。我们的研究结果表明,LPS组的超氧化物歧化酶(SOD)、硫醇和过氧化氢酶(CAT)水平显著降低;这些水平随后被银纳米颗粒恢复。银纳米颗粒还能降低lps注射大鼠心脏和主动脉组织中的NO和MDA水平。在临床试验研究中,这种新型纳米颗粒可能用于修复败血症引起的人类心脏和主动脉损伤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Treatment of Aortic and Cardiac Injury Following Sepsis by Curcumin Green-Formulated Silver Nanoparticles

Treatment of Aortic and Cardiac Injury Following Sepsis by Curcumin Green-Formulated Silver Nanoparticles

The main secondary metabolite of turmeric is a polyphenol molecule called curcumin. According to Chinese traditional medicine, the chemical offers a number of advantages. Nevertheless, no research has examined the possible advantages of its nanoparticles in reducing sepsis-induced cardiac and aortic damage thus far. Therefore, the purpose of this work was to examine how oxidative stress markers and nitric oxide (NO) are affected by silver nanoparticles green-formulated by curcumin in sepsis-induced aortic and cardiac damage. This study characterizes and synthesizes silver nanoparticles using green formulation techniques. Several spectroscopic techniques were used to analyze the silver nanoparticles, and their ability to cure sepsis-induced cardiac and aortic damage was also investigated. Adult male Wistar rats were classified into four groups for the in vivo design: control, lipopolysaccharide, and silver nanoparticles (50 and 200 μg/kg, oral). For 14 days, lipopolysaccharide (LPS) was injected every day. Silver nanoparticle therapy began 3 days before the delivery of LPS and continued during the administration of LPS. Antioxidant enzyme, thiols, NO, and malondialdehyde (MDA) levels were assessed after the research. The findings imply that silver nanoparticles can prevent cardiovascular damage caused by LPS by reducing NO generation and enhancing redox hemostasis. Our results demonstrated that the LPS group's levels of superoxide dismutase (SOD), thiols, and catalase (CAT) were significantly reduced; these levels were subsequently restored by silver nanoparticles. Silver nanoparticles also reduced NO and MDA levels in the cardiac and aortic tissues of LPS-injected rats. The new nanoparticles might be utilized to repair human cardiac and aortic damage caused by sepsis following clinical trial research.

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来源期刊
Applied Organometallic Chemistry
Applied Organometallic Chemistry 化学-无机化学与核化学
CiteScore
7.80
自引率
10.30%
发文量
408
审稿时长
2.2 months
期刊介绍: All new compounds should be satisfactorily identified and proof of their structure given according to generally accepted standards. Structural reports, such as papers exclusively dealing with synthesis and characterization, analytical techniques, or X-ray diffraction studies of metal-organic or organometallic compounds will not be considered. The editors reserve the right to refuse without peer review any manuscript that does not comply with the aims and scope of the journal. Applied Organometallic Chemistry publishes Full Papers, Reviews, Mini Reviews and Communications of scientific research in all areas of organometallic and metal-organic chemistry involving main group metals, transition metals, lanthanides and actinides. All contributions should contain an explicit application of novel compounds, for instance in materials science, nano science, catalysis, chemical vapour deposition, metal-mediated organic synthesis, polymers, bio-organometallics, metallo-therapy, metallo-diagnostics and medicine. Reviews of books covering aspects of the fields of focus are also published.
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