Applied Organometallic Chemistry最新文献

{"title":"Efficient Photocatalytic Degradation of Tetracycline by S-Type Heterojunction BiOBr/h-MoO3 With Oxygen-Rich Vacancies Under Visible Light","authors":"Yi Ren,&nbsp;Jiaxuan Yang,&nbsp;Hongxia Li,&nbsp;Xiaohui Niu,&nbsp;Xiaoyu Liu,&nbsp;Li Chen,&nbsp;Haiyan Fan,&nbsp;Kunjie Wang","doi":"10.1002/aoc.70356","DOIUrl":"https://doi.org/10.1002/aoc.70356","url":null,"abstract":"<div>\u0000 \u0000 <p>A BiOBr/h-MoO₃ heterostructure photocatalyst with oxygen vacancy (OV) modulation was synthesized via solvothermal in situ precipitation, exhibiting enhanced visible-light-driven tetracycline (TC) degradation performance. The composite demonstrated 1.5- and 4-fold higher TC degradation rates compared to pristine BiOBr and h-MoO₃, respectively. Structural characterization via XRD, XPS, and FTIR confirmed the successful synthesis of the composite with controlled OV concentration and interfacial bonding characteristics. Photoluminescence (PL) and electron spin resonance (ESR) analyses revealed that the BiOBr/h-MoO₃ heterojunction achieved optimal reactive oxygen species (ROS) production and minimized electron–hole recombination. Under optimized conditions (catalyst dosage: 10 mg L⁻¹, TC concentration: 10 mg L⁻¹, pH 10), the system attained 84% TC degradation within 60 min while maintaining 80% efficiency after five operational cycles. Mechanistic studies identified hydroxyl radicals (<span></span>OH) and photogenerated holes (h⁺) as dominant active species, with OVs critically enhancing interfacial charge transfer efficiency. This work provides a viable strategy for constructing OV-engineered heterojunction photocatalysts for antibiotic wastewater treatment.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 9","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144811090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytotoxic Potential of Biogenic Gold Nanoparticles Functionalized With Brazilian Red Propolis in Prostate Cancer Cell Models","authors":"Caroline E. A. Botteon,&nbsp;Isabela A. Justino,&nbsp;Robson Amaral,&nbsp;Otávio Berenguel,&nbsp;Larissa P. de Castro,&nbsp;Gabriel B. M. Teobaldo,&nbsp;Cristiano L. P. de Oliveira,&nbsp;Jennyfer A. Aldana-Mejía,&nbsp;Jairo K. Bastos,&nbsp;Priscyla D. Marcato","doi":"10.1002/aoc.70350","DOIUrl":"https://doi.org/10.1002/aoc.70350","url":null,"abstract":"<p>Gold nanoparticles (GNPs) have been investigated for their potential application in medicine. GNPs can be synthesized by various methods, including green synthesis, a simple, low-cost, and environment-friendly methodology that provides an easy way to coat the nanoparticle's surface with natural molecules. Functionalization of the surface of GNPs with natural ligands that have pharmacological activities, such as Brazilian red propolis (BRP) extract, expands their biomedical applications, especially in cancer treatment. Therefore, the objective of this research was to investigate the cytotoxic activity of biogenic gold nanoparticles functionalized with BRP extract in vitro on prostate cancer (PCa) models. To achieve this, spherical GNPs were prepared by green synthesis using BRP extract (BRP-GNPs) as a reducing and stabilizing agent. The formulation was characterized by dynamic light scattering (DLS), demonstrating a monomodal size distribution and negative zeta potential. X-ray photoelectron spectroscopy (XPS) and small angle x-ray scattering (SAXS) analyses indicated the existence of BRP organic compounds on the GNP's surface and the presence of aggregates. BRP-GNPs showed cytotoxic activity against prostate cancer cells (PC3 and LNCaP), exhibiting IC₅₀ values of 45.09 and 95.15 μg/mL, respectively. The nanoparticles were able to inhibit cell proliferation, arrest the cell cycle, and trigger cell death through apoptosis and necrosis mechanisms. Compared with the 2D (monolayer) culture model, BRP-GNPs exhibited a greater cytotoxic effect and cellular internalization in 3D (spheroid) culture models of PCa. Our study has demonstrated that the combination of BRP and GNPs is a promising candidate for antitumor and preventive applications against PCa.</p>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 9","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aoc.70350","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144782287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and Study of Novel Ni(II), Co(II), and Cu(II) Complexes With Hydrazone Ligand: Structural Characterization, DFT Analysis, and Assessment of Cytotoxic and Antioxidant Activities Supported by Molecular Docking Studies","authors":"Sara F. El-Beltagy,&nbsp;Yasmeen G. Abou El-Reash,&nbsp;Sahar Abdalla,&nbsp;Ola A. El-Gammal,&nbsp;A. A. Mohamed,&nbsp;G. M. Abu El-Reash","doi":"10.1002/aoc.70344","DOIUrl":"https://doi.org/10.1002/aoc.70344","url":null,"abstract":"<div>\u0000 \u0000 <p>A series of Ni(II), Co(II), and Cu(II) complexes with <i>N</i>′¹,<i>N</i>′²-bis((E)-1-(pyridin-2-yl)ethylidene)oxalohydrazide (H₂OHS) were synthesized and characterized using FT-IR, UV–Vis, NMR, ESR, and thermal analyses. Density functional theory (DFT) calculations confirmed structural stability, electronic properties, HOMO–LUMO gaps, and charge-transfer characteristics, supported by reduced density gradient (RDG) and noncovalent interaction (NCI) analyses. The complexes exhibited distinct geometries—octahedral for Ni(II), tetrahedral for Co(II), and square planar for Cu(II). Thermal degradation studies using Coats–Redfern and Horowitz–Metzger methods revealed high thermal stability. Biological evaluations demonstrated strong antimicrobial activity against <i>Candida albicans</i>, <i>Staphylococcus aureus</i>, <i>E</i>s<i>cherichia coli</i>, significant antioxidant potential (DPPH and ABTS), and potent cytotoxic effects against HepG2, MCF-7, HCT116, and A549 cancer cell lines. Molecular docking studies confirmed strong ligand–receptor interactions, correlating with biological efficacy. These findings highlight the complexes' promising potential as multifunctional therapeutic agents in antimicrobial, antioxidant, and anticancer applications.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 9","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144782285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-MOF and c-MWCNT Nanocomposite–Based Impedimetric Immunosensor for Sensing of Human Serum Albumin","authors":"Divya,&nbsp;Rohini Kumari,&nbsp;Pranjal Chandra","doi":"10.1002/aoc.70343","DOIUrl":"https://doi.org/10.1002/aoc.70343","url":null,"abstract":"<div>\u0000 \u0000 <p>Cobalt metal–organic framework (Co-MOF), also called zeolite imidazole framework (ZIF-67), a subclass of MOF, is a burgeoning class of crystalline materials that features high porosity, large surface areas, remarkable stability, and flexibility. A coordination bond between an organic linker and a redox-active cobalt metal center forms ZIF-67 MOF, which has a unique architecture resembling zeolites. However, ZIF-67’s limited conductivity impedes its application for electrochemical sensing. Considering this, we designed Co-MOF-carboxylated multiwalled carbon nanotubes (c-MWCNTs) nanohybrid, which was further functionalized with an anti-ALB antibody to enable the selective electrochemical evaluation of albumin (ALB), a clinically proven kidney biomarker. ALB, the most prevalent protein secreted by hepatocytic cells, performs a number of essential bodily functions; however, a deviation from a normal level is prognostic of kidney failure and other illnesses. Several physical and electrochemical methods were utilized to thoroughly characterize the developed immunosensing device. Following that, electrochemical impedance spectroscopy (EIS) was employed to evaluate its efficacy, and the linearity and detection limit were estimated as 0.1–60 mg/mL and 0.024 mg/mL, respectively. These remarkable outcomes are the result of c-MWCNT and Co-MOF synergistic effects, and they present a cutting-edge approach for point-of-care ALB detection using composite materials based on MOFs.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 9","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144782284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of GO-NU1000 MOF Electrode and Sustainable HNFM@ZnCl3 DES Electrolyte, Solvent and Catalyst: A Rapid Electro-Organic C-H Amination Approach for Synthesizing Indoles and Evaluation of Their Anti-Cancer Activity","authors":"Obaid Afzal,&nbsp;Menshawy A. Mohamed,&nbsp;Taibah Aldakhil,&nbsp;Alhumaidi Alabbas,&nbsp;Safar M. Alqahtani","doi":"10.1002/aoc.70337","DOIUrl":"https://doi.org/10.1002/aoc.70337","url":null,"abstract":"<div>\u0000 \u0000 <p>To perform chemical reactions, whether through traditional methods or electrochemical processes, the inclusion of a solvent, catalyst, and electrolyte is crucial for achieving optimal results. However, relying on a variety of materials and reagents can result in environmental pollution, higher production costs, and complications in wastewater treatment. This study introduces a novel electrode made from graphene oxide (GO) modified with the NU1000 metal–organic framework (MOF) and utilizes HNFM@ZnCl₃ deep eutectic solvent (DES) as a multifunctional electrolyte, solvent, and catalyst. The GO-NU1000 MOF electrode aims to improve electrical conductivity and surface area for efficient electro-synthesis. The HNFM@ZnCl₃ DES showcases versatility by functioning as an electrolyte, solvent, and catalyst, which helps reduce production costs and environmental impact. The innovative system was applied in a rapid electro-organic C-H amination method to synthesize indole derivatives <b>3(a-m)</b> from 2-phenylacetaldehyde <b>1(a-m)</b> and NH₃ <b>2(a)</b> gas, achieving yields of 90 to 97% at a current of 5 mA within 1 h at room temperature. Characterization of the electrode was performed using various techniques including SEM, FT-IR, EDS, TGA, XPS, BET, CV, and XRD. The synthesized indole derivatives were further characterized through melting point analysis, CHN, and 1HNMR testing. The study emphasizes the integration of advanced materials and sustainable electrolytes in electrochemical processes, promoting more efficient and environmentally friendly synthetic methods in organic chemistry. The synthesized indole derivatives <b>3(a-m)</b> were evaluated for their cytotoxic effects on HT-29 colon cancer, MDA-MB-231 breast cancer, and HEK-293 normal cell lines. Notably, some compounds exhibited IC50 values below 10 μM against MDA-MB-231 and HT-29 cell lines, indicating strong anticancer potential. In contrast, all indole derivatives showed weak cytotoxicity on HEK-293 normal cells with IC50 values ranging from 56 to 138 μM.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 9","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144773835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, Spectral Characterization, DFT Calculations, Cell Cycle Arrest, Apoptosis Assay, Cytotoxicity, DNA Binding and Biological Evaluation Study of Novel NO Pincer-Type 2-(5,6-Diflorobenzo[d]thiazol-2-yl)phenol and Its Bis(2-(5,6-diflorobenzo[d]thiazol-2-yl)phenoxy) Dichloro Platinum(IV) Trihydrate","authors":"Nada M. Alatawi,&nbsp;Ibtisam Mousa,&nbsp;Deemah Mizher Alenazy,&nbsp;Hind Ahmed Siddiq,&nbsp;Abeer A. Ageeli,&nbsp;Nada D. Alkhathami,&nbsp;Abdel-Nasser M. A. Alaghaz","doi":"10.1002/aoc.70313","DOIUrl":"https://doi.org/10.1002/aoc.70313","url":null,"abstract":"<div>\u0000 \u0000 <p>A new novel NO pincer-type bezo<i>[d]</i>thiazole ligand, 2-(5,6-diflorobenzo[d]thiazol-2-yl)phenol (H-DFBTP), is synthesized through reacting 2-amino-4,5-diflorobenzenethiol and 2-hydroxybenzoic acid in a 1:1 ratio. A nano-sized tetravalent Pt(IV) complex is created and subsequently characterized using various physical methods. The complex's structural geometry is validated by employing the DFT approach, utilizing DMOL³ determinations. Based on the elemental analysis results, the complexes are inferred to follow the overall formula [Pt(DFBTP)₂Cl₂].3H₂O. Quantum chemical calculations, along with electronic spectra findings, indicate that the Pt(IV) complex exhibits an octahedral configuration. The EDX, XRPD, TEM, and AFM analyses of the studied Pt(IV) complex unveil distinct and strong diffraction peaks, indicating its crystalline nature and providing evidence of its nano-sized particle sizes. Absor ption titration techniques and viscosity measurements were employed to inspect the interaction between CT-DNA and the Pt(IV) complex. The findings showed that the complex's binding to CT-DNA occurred throughout a typical intercalation mechanism. The anticancer properties of isolated compounds were evaluated in vitro using the MTT assay, targeting both normal cell lines (NHDF) and cancer cell lines (HeLa, HepG2, MCF-7, and A549). Findings revealed that the tetravalent platinum complex effectively inhibits the proliferation of cancer cells (HeLa: 24.68 ± 1.29 μg/mL; HepG2: 32.2 ± 1.69 μg/mL; MCF-7: 20.12 ± 1.00 μg/mL; A549: 23.46 ± 1.17 mg/mL) while sparing normal cells (NHDF: 109.26 ± 5.46 μg/mL). Additionally, the isolated compounds demonstrated notable antioxidant and antimicrobial capabilities. Both the ligand and the Pt complex exhibited strong potent antioxidant activity by neutralizing four distinct free radicals, as well as antimicrobial efficacy against <i>C. albicans</i> and <i>E. coli</i>. Moreover, the Pt(IV) complex exhibited the capability for triggering DNA damage in HepG2 cells, resulting in dose-dependent cell apoptosis. Subsequent investigations revealed that the complex triggered cell cycle arrest during the phases S and G2.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 9","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144773884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monometallic Pd Loaded on N-CNTs by Seed Growth Method as an Efficient Catalyst for Li-O2 Battery","authors":"Zhen Wang,&nbsp;Hao Wu,&nbsp;Zhihao Zhao,&nbsp;Yanjia Zhang,&nbsp;Jie Xiao,&nbsp;Peng Dong,&nbsp;Lei Zhang,&nbsp;Xiaoyuan Zeng","doi":"10.1002/aoc.70327","DOIUrl":"https://doi.org/10.1002/aoc.70327","url":null,"abstract":"<div>\u0000 \u0000 <p>The enormous potential for polarization and poor cycling performance of the cathode restrains the commercial application of Li-O₂ batteries. Therefore, designing effective cathode catalysts for high-performance Li-O₂ batteries is crucial. In this study, nitrogen-doped carbon nanotubes (N-CNTs) modified with ultra-low loading cubic monometallic palladium particles (mPd/N-CNTs) were used as the cathode catalyst for the Li-O₂ batteries. The spray pyrolysis chemical vapor deposition method synthesized N-CNTs that have a special open 3D multi-channel structure that benefits the three-phase reaction interface and promotes the deposition/decomposition of thin-film Li₂O₂. In addition, the seed growth method synthesized high-efficiency catalytic activity of cubic monometallic Pd nanoparticles that encourages the decomposition of discharge products. Hence, the Li-O₂ batteries utilize mPd/N-CNTs as cathode catalysts to deliver a large discharge specific capacity of 11.79 mAh cm⁻², low overpotential (0.93 V), and an ultralong cycling life of 400 cycles/4800 h. Overall, this study provides a feasible idea for designing efficient and stable bifunctional catalysts with ultra-low loading of precious metal, which could have significant implications for developing high-performance Li-O₂ batteries.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 9","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144767478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carboxypyridine-Functionalized MOFs for Enhanced Au(III) Recovery","authors":"Xinliang Wang,&nbsp;Zhiwei Wang,&nbsp;Changqing Xia,&nbsp;Zhengshen Bao,&nbsp;Dehong Xu,&nbsp;Yinhai Ma,&nbsp;Shixing Wang,&nbsp;Weili Li","doi":"10.1002/aoc.70351","DOIUrl":"https://doi.org/10.1002/aoc.70351","url":null,"abstract":"<div>\u0000 \u0000 <p>In this work, functional organic ligands are incorporated into the structurally stable metal–organic framework (UiO-66-SPA) to regulate the electrostatic potential and coordination positions of its inner and outer surfaces. The gold extraction efficiency of functionalized MOFs from acidic gold-containing wastewater is 2.65 times that of non-functionalized UiO-66-(SH)₂. In this way, efficient recovery of Au(III) in complex trace Au(III) wastewater is achieved. After multiple regeneration cycles, UiO-66-SPA still maintains 99% of its adsorption capacity. Through characterization techniques such as X-ray photoelectron spectroscopy (XPS), density functional theory (DFT) calculations, kinetics, and thermodynamics, it is confirmed that the adsorption of Au(III) by UiO-66-SPA involves the synergistic effect of chelation coordination. This work provides a way to enhance adsorption for the post-modification of MOFs. The experiment of recovering Au(III) from industrial simulated wastewater improves the experimental data for the application of this material in Au(III) recovery. The research in this article is of great significance for MOFs materials in environmental protection, sustainable development of non-renewable resources, and green development of Au(III) resources.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 9","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144767474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-Pot Catalytic Syntheses of Quinazolinones by Coupling of 2-Aminobenzamide With Primary Alcohols Using a Nickel(II)-ONO Pincer-Like Complex","authors":"Kinche Shakunthala,&nbsp;Seema Nagarajan,&nbsp;Gunasekaran Balamurugan,&nbsp;Samudranil Pal","doi":"10.1002/aoc.70354","DOIUrl":"https://doi.org/10.1002/aoc.70354","url":null,"abstract":"<div>\u0000 \u0000 <p>One-pot syntheses of biologically relevant quinazolinones using acceptorless dehydrogenative coupling (ADC) of 2-aminobenzamide with various alcohols in the presence of a catalytic amount of [NiL(PPh₃)] (<b>1</b>) (H₂L represents N-(2-hydroxy-1-naphthylidene)-N′-(2-thenoyl)hydrazine, where two Hs are the dissociable phenolic and amide protons) are reported. The identity and purity of <b>1</b> have been confirmed by infrared and ¹H NMR spectroscopic and X-ray crystallographic studies. A variety of substituted derivatives of quinazolinones have been successfully synthesized using a diverse range of alcohols in 40%–83% yields using 5 mol% of <b>1</b>. The detailed mechanistic investigation has revealed that the presence of <b>1</b> leads to the dehydrogenation of alcohol into aldehyde, followed by the formation of a cyclic aminal via condensation of the aldehyde with 2-aminobenzamide. Ultimately, the dehydrogenation of the aminal provides the desired quinazolinone, producing water and dihydrogen as the by-products, thereby making the present catalytic method environmentally benign and sustainable.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 9","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144767477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eu6-Cluster-Based Metal–Organic Framework Biosensor for Sensitive Luminescence Detection of Catecholamine Metabolites","authors":"Fang Cui,&nbsp;Yue-Lin Liu,&nbsp;Xin-Cheng Wang,&nbsp;Sheng-Li Hou,&nbsp;Zi-Hao Zhu,&nbsp;Zhuo-Hao Jiao","doi":"10.1002/aoc.70341","DOIUrl":"https://doi.org/10.1002/aoc.70341","url":null,"abstract":"<div>\u0000 \u0000 <p>Vanillylmandelic acid (VMA) and homovanillic acid (HVA), as metabolic byproducts of catecholamines, may indicate the presence of adrenal tumors, such as neuroblastoma, when their levels are abnormal in urine. Therefore, the detection of VMA and HVA levels is of significant clinical importance. Herein, a novel Eu₆-cluster-based metal–organic framework {[(CH₃)₂NH₂]₂[Eu₆(IDA)₆(μ₃-X)₈]·1.5DMF·19H₂O}_<i>n</i> (<b>1,</b> X: OH⁻/F⁻) with a cage-rich structure was synthesized using the cost-effective ligand 1H-indole-2,5-dicarboxylic acid (IDA). <b>1</b> exhibits excellent solvent and pH stability, making it suitable as a fluorescent probe for detecting the target biomarkers VMA and HVA. The probe demonstrated high sensitivity and a broad linear range of VMA and HVA, with the limit of detection (LOD) as low as 3.46 and 14.74 μmol·L⁻¹, respectively. Additionally, it displayed robust anti-interference properties against common urinary components and its fluorescence remained stable across a wide pH range of 4–8, enabling reliable detection in complex biological environments. Meanwhile, the probe was recyclable for at least five cycles, maintaining structural integrity and sensing performance. Mechanism investigation reveals that fluorescence resonance energy transfer (FRET) may occur between the MOF and HVA, and the inner filter effect (IFE) is responsible for luminescence quenching of VMA to <b>1</b>. These findings highlight the potential of <b>1</b> as a cost-effective, efficient, and reusable probe for biomarker VMA and HVA detection, providing valuable insights for the development of advanced diagnostic tools for disease monitoring.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 9","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144767476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}