Sundus Azhar, Khuram Shahzad Ahmad, Isaac Abrahams, Tenzin Ingsel, Ram K. Gupta, Essam A. Al-Ammar, Ghulam Abbas Ashraf, Mahwash Mahar Gul
{"title":"Innovative Nanoarchitectures: CuO:Er2O3 Synergy for Enhanced Performance in Energy Storage and Generation Applications","authors":"Sundus Azhar, Khuram Shahzad Ahmad, Isaac Abrahams, Tenzin Ingsel, Ram K. Gupta, Essam A. Al-Ammar, Ghulam Abbas Ashraf, Mahwash Mahar Gul","doi":"10.1002/aoc.7795","DOIUrl":"https://doi.org/10.1002/aoc.7795","url":null,"abstract":"<div>\u0000 \u0000 <p>In this study, we have synthesized facile Cu-based CuO:Er<sub>2</sub>O<sub>3</sub> nanoelectrode material for energy storage and generation. CuO:Er<sub>2</sub>O<sub>3</sub> nanomaterial was synthesized employing phyto-extract of <i>Amaranthus viridis</i> L. (AVL) as stabilizing and reducing agents. Spherical-shaped CuO:Er<sub>2</sub>O<sub>3</sub> nanomaterial was initially employed to study supercapacitor behavior. The specific capacitance of 82.25 F/g was found at 0.5 A/g by galvanostatic charge–discharge, whereas the value of 319 F/g was achieved at 2 mV/s by cyclic voltammetry (CV) measurements. Furthermore, CuO:Er<sub>2</sub>O<sub>3</sub> electrode was investigated for water splitting energy generation potential and revealed an overpotential value of 323 mV at 10 mA/cm<sup>2</sup> for hydrogen evolution reaction (HER). However, for the oxygen evolution reaction (OER), an overpotential value of 370 mV was found. The electrochemical impedance analysis revealed the faster flow of electrons and ions, suggesting great conductivity and lower resistance of the fabricated electrode. Thus, current electrochemical results are proposing CuO:Er<sub>2</sub>O<sub>3</sub> as an competent electrode for overall energy-generating as well as storage applications.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142868404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ali Basem, Shomansur Sh. Sagdullaev, Zaman Abdalhussein Ibadi Alaridhee, Aiham O. Altayeh, Nadhir N. A. Jafar, Majid S. Jabir, Hasan Majdi, Ameer H. Al-Rubaye, Moamel Dheyaa Jumaah, Lola M. Usmonova, Hazem A. Ghabbour, Abdulrahman A. Almehizia
{"title":"Novel Eco-Friendly Electrode: Copper Nanoparticle-Doped MWCNTs for Green Electro-Organic Synthesis of 1,2,3-Triazoles With ChCl/Urea as a Solvent and Cocatalyst","authors":"Ali Basem, Shomansur Sh. Sagdullaev, Zaman Abdalhussein Ibadi Alaridhee, Aiham O. Altayeh, Nadhir N. A. Jafar, Majid S. Jabir, Hasan Majdi, Ameer H. Al-Rubaye, Moamel Dheyaa Jumaah, Lola M. Usmonova, Hazem A. Ghabbour, Abdulrahman A. Almehizia","doi":"10.1002/aoc.7789","DOIUrl":"https://doi.org/10.1002/aoc.7789","url":null,"abstract":"<div>\u0000 \u0000 <p>Meticulous electrode design is pivotal in advancing greener and more sustainable electro-organic synthesis practices. In this research, our team designed and synthesized a copper-doped electrode on multiwalled carbon nanotubes (MWCNTs) and characterized it using Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), thermogravimetric analysis (TGA), Brunauer–Emmett–Teller (BET) analysis, X-ray diffraction (XRD) analysis, X-ray photoelectron spectroscopy (XPS), and cyclic voltammetry (CV) analysis. Subsequently, this electrode was utilized as a catalyst at the electrode surface, serving as a cathode in electro-oxidation reactions in the presence of phenylacetylene, sodium azide (NaN<sub>3</sub>), and benzyl halide for the production of 1,2,3-triazole derivatives under ambient temperature, within a 30-min reaction time, and at atmospheric pressure, achieving an efficiency level ranging from good to excellent, specifically between 88% and 96%. The synthesized 1,2,3-triazole derivatives were identified using proton nuclear magnetic resonance (<sup>1</sup>H NMR) spectroscopy, CHN elemental analysis, and melting point. In this paper, choline chloride/urea deep eutectic solvents (DES) serve multiple roles in the reaction mechanism. They function as solvents and co-catalysts, generate weak bases, and provide numerous advantages in green chemistry. These advantages include low toxicity, reduced environmental risks, improved atom economy, and non-volatility, making them safer alternatives to traditional organic solvents.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142868047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhi-Chao Yin, Manaswini Ray, Cai-Yang Liu, Trilochan Dakua, Mohammad Khalid Parvez, Mohammed S. Al-Dosari, Aurobinda Mohanty, Jun-Cheng Jin
{"title":"A Cd (II)-based Metal–Organic Framework as Switch-Off Fluorescence Sensors for Antibiotic Detection","authors":"Zhi-Chao Yin, Manaswini Ray, Cai-Yang Liu, Trilochan Dakua, Mohammad Khalid Parvez, Mohammed S. Al-Dosari, Aurobinda Mohanty, Jun-Cheng Jin","doi":"10.1002/aoc.7792","DOIUrl":"https://doi.org/10.1002/aoc.7792","url":null,"abstract":"<div>\u0000 \u0000 <p>Detecting antibiotic residues is crucial for monitoring their excessive use in healthcare and agricultural practices. Herein, a new 3D metal–organic framework (MOF) containing {[Cd (bpyp)(sdba)]·DMF·2H<sub>2</sub>O}<sub>n</sub> (<b>1</b>) (bpyp = 2,5-bis (pyrid-4-yl)pyridine and H<sub>2</sub>sdba = 4,4′-sulfonyldibenzoic acid) has been designed and synthesized. MOF <b>1</b> displays sensitive detection tetracycline (TCY) with a limit of detection below 7.67 × 10<sup>−6</sup> M in an aqueous solution. The detection mechanism involves competitive absorption between MOF <b>1</b> and antibiotics, supported by UV–vis spectroscopy and fluorescence lifetime measurements. MOF <b>1</b> exhibits a visible fluorescence response to TCY under a 254 nm UV lamp. MOF <b>1</b> is applied in the quantitative detection of TCY in lake water with the recovery based on the sensing platform was 92.26–107.54% with RSD (%) less than 4.38%, indicating outstanding reliability.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142868041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diacetyl Monoxime-Based N∩N Donor Schiff Base and Its Zn(II) Complexes. In Vitro and In Silico Analysis","authors":"Faezeh Shahriari, Somaye Shahraki, Effat Dehghanian","doi":"10.1002/aoc.7763","DOIUrl":"https://doi.org/10.1002/aoc.7763","url":null,"abstract":"<div>\u0000 \u0000 <p>Schiff bases are introduced as versatile pharmacophores for the design and development of various bioactive compounds. Oxime-based Schiff base ligands form an important and flexible class of ligands that have attracted attention due to their wide applications in various fields. Here, novel 3-(2-hydroxyphenyl-imino)butan-2-one oxime, (<b>HPIO</b>) Schiff base and Zn(II) complexes derived from it, [Zn(bpy)(HPIO)](NO<sub>3</sub>)<sub>2</sub>, <b>C1</b>, (bpy = 2,2′-bipyridine) and [Zn(HPIO)<sub>2</sub>]Cl<sub>2</sub>, <b>C2</b>, were synthesized and characterized. Theoretical studies showed that both complexes are reactive and have high pharmacological affinity. Experimental investigations were done to compare some biological properties of the complexes. Antioxidant studies using ·DPPH (2,2-diphenyl-1-picrylhydrazyl) assay presented the following trend: <b>C1</b> > <b>C2</b> > <b>HPIO</b>. Considering the importance of the antioxidant enzyme catalase in removing reactive oxygen species (ROS), the binding process of <b>C1</b>/<b>C2</b> with catalase was evaluated. Kinetic studies showed that <b>C1</b>/<b>C2</b> can inhibit the catalytic performance of catalase by mixed-type inhibition mechanism. The <b>C1</b> and <b>C2</b> quenched the catalase fluorescence emission with static quenching mechanism. The binding affinity to catalase was higher for <b>C1</b> than <b>C2</b> (<i>K</i><sub><i>b</i></sub> = 1.51 and 0.89 × 10<sup>5</sup> M<sup>−1</sup> for <b>C1</b> and <b>C2</b>, respectively at 305 K). In <b>C1</b>/<b>C2</b> interaction with catalase, which was an exothermic and spontaneous process, hydrogen bonds, van der Waals forces, and hydrophobic interactions played a decisive role and strongly confirmed by molecular docking data. Tracking the structural changes of catalase showed that enzyme undergoes structural changes in the presence of both complexes.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142868038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. M. Tawfiq, Hanan Adnan Shaker Al Naymi, Shatha M. H. Obaid, Amer J. Jarad, Taghreed H. Al-Noor, Ali J. Al-Sarray
{"title":"Synthesis, Characterization, Molecular Docking, Cytotoxicity, and Antimicrobial Activity of Schiff Base Ligand and Its Metal Complexes","authors":"K. M. Tawfiq, Hanan Adnan Shaker Al Naymi, Shatha M. H. Obaid, Amer J. Jarad, Taghreed H. Al-Noor, Ali J. Al-Sarray","doi":"10.1002/aoc.7781","DOIUrl":"https://doi.org/10.1002/aoc.7781","url":null,"abstract":"<div>\u0000 \u0000 <p>A Schiff base ligand (L) was synthesized via condensation of <i>N</i>-(1-naphthyl)ethylenediamine dihydrochloride with phthalaldehyde. The ligand was characterized by FT-IR, UV–Vis, <sup>1</sup>H NMR, mass spectrometry, and elemental analysis (C, H, N). Five metal complexes (Co(II), Ni(II), Cu(II), Zn(II), and Cd(II)) were prepared with the ligand in a 1:1 (M:L) ratio using an aqueous ethanol solution. The complexes were characterized by FT-IR, UV–Vis, mass spectrometry, and elemental analysis (C, H, N). Additionally, <sup>1</sup>H NMR spectroscopy was employed for Cd(II) complex. Antimicrobial activity of the ligand and its metal complexes against pathogenic bacteria (<i>K. pneumoniae</i>, <i>E. coli</i>, <i>S. aureus</i>, and <i>S. epidermidis</i>) and fungus (<i>C. albicans</i>) were evaluated using the agar well diffusion method. All compounds exhibited inhibitory effects with zone diameters ranging from 8 to 16 mm. The ligand and complexes also displayed significant anticancer activity against a mammary carcinoma cell line. Among them, Zn(II) and Cu(II) complexes demonstrated the highest inhibitory effects (70.68% and 70.57%, respectively), followed by the ligand (61.35%) and Co(II), Cd(II), and Ni(II) complexes (60.34%, 58.96%, and 41.63%, respectively). IC50 values followed a similar trend, ranging from 31.69% (Co(II)) to 165.7% (Cd(II)). Molecular docking studies indicated strong binding affinities of the ligand and the Zn(II) complex to the estrogen receptor.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142868002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christina Kannigadu, Helena D. Janse van Rensburg, Janine Aucamp, Keisuke Suganuma, David D. N'Da
{"title":"Exploration of Novel “Ferroxazide/Ferrazone” Derivatives as Antitrypanosomatid Agents: Design, Synthesis, and Biological Efficacy","authors":"Christina Kannigadu, Helena D. Janse van Rensburg, Janine Aucamp, Keisuke Suganuma, David D. N'Da","doi":"10.1002/aoc.7769","DOIUrl":"https://doi.org/10.1002/aoc.7769","url":null,"abstract":"<p>Trypanosomatids are the etiologic agents of numerous parasitic diseases that cause significant morbidity and mortality in millions of people and animals around the world. Approved antitrypanosomatid agents are limited by several drawbacks, such as severe toxicity, lengthy treatment, need for hospitalization, and susceptibility to drug resistance. Consequently, parasitic diseases remain a substantial public health problem, and new drugs are required, especially drugs suitable for rural health systems that have limited resources. In an attempt to find antitrypanosomatid agents to address this problem, we report here on the synthesis and biological efficacy of ferrocene derivatives of nifuroxazide and nitrofurazone, which were designed by replacing the nitrofuran scaffold within their structures with the ferrocene moiety. The 1,2-disubstituted ferrocene intermediates <b>8</b> and <b>9</b>, featuring amine and carboxaldehyde groups, exhibited the best in vitro antiamastigote activity against <i>Leishmania major</i> strain NIH S and <i>Leishmania donovani</i> strain 9515, respectively. Ferroxazide derivative <b>15</b> was revealed as a mammalian cell nontoxic hit compound against <i>Trypanosoma congolense</i> strain IL3000 trypomastigotes; however, no in vivo treatment efficacy was observed against <i>T. congolense</i> strain IL3000-infected BALB/c mice during a preliminary animal study. The synthesized ferrocene derivatives were poorly soluble in the in vitro and in vivo testing media, hindering uniform sampling and dosing. This study's outcome indicates that replacing the 5-nitrofuran moiety with ferrocene did not increase antitrypanosomatid activity compared to the nitrofuran parent drugs nifuroxazide and nitrofurazone.</p>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aoc.7769","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142867982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synthesis of Quinolines Catalyzed by Bidentate Terpyridine Mn(I) Complex","authors":"Shang Wu, Penghui Zhang, Xin Sun, Jiankun Li, Ningning Wang, Xia Wang, Zhe Wang, Yanbin Wang, Quanlu Yang","doi":"10.1002/aoc.7797","DOIUrl":"https://doi.org/10.1002/aoc.7797","url":null,"abstract":"<div>\u0000 \u0000 <p>A method for efficient synthesis of quinolines via acceptorless dehydrogenative condensation is presented. A series of quinolines are obtained by the coupling reaction of 2-aminobenzyl alcohols with secondary alcohols in the presence of bidentate terpyridine Mn(I) complex in good to excellent yields. Pleasantly, various substituted secondary alcohols and substituted aminobenzyl alcohols all provide quinolines with good functional group tolerance. Importantly, this investigation also provides a green and environmentally friendly protocol for constructing heterocyclic compounds.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142868085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Experimental and Computational Insights Into Organotellurium (IV) Complexes as Potent PfNDH2 Inhibitors: Synthesis, Characterization, and Antimalarial Evaluation","authors":"Anisha Bhardwaj, Amit Dubey, Aisha Tufail, Nasir Tufail, Kamlesh Jangra, Sapana Garg","doi":"10.1002/aoc.7778","DOIUrl":"https://doi.org/10.1002/aoc.7778","url":null,"abstract":"<div>\u0000 \u0000 <p>The study examines the binding affinities and pharmacological potential of synthesized metal compounds with PfNDH2 in <i>Plasmodium falciparum</i>. So as to identify the combatting agent for malaria, six new organotellurium (IV) complexes (8a–8f) were prepared through a condensation reaction of 3-methyl-2-thiophene carboxaldehyde and <i>p</i>-nitroaniline. The synthesized compounds were inclusively characterized through physical and spectral techniques signifying a distorted octahedral geometry. The reported complexes were screened for antimalarial and antioxidant activities and analyzed using micro assays and DPPH assays, respectively. Using docking interactions, the research evaluates the binding energies, hydrogen bonds, and steric interactions of various compounds with PfNDH2, aiming to identify promising candidates for antimalarial drug development. Among the compounds, 8f showed the strongest binding affinity, with the lowest binding energy of −135.626 kcal/mol, and diverse hydrogen bonds with the target enzyme. Structure-based pharmacophore modeling revealed critical interaction profiles and selectivity scores for the compounds, with 8f emerging as a promising candidate. Molecular electrostatic potential (MESP) analysis offered insights into the distribution of electron density within the compounds, influencing their reactivity and potential as antimalarial agents. ADMET analysis highlighted the pharmacokinetic and toxicological profiles of the compounds, revealing critical aspects for optimizing safety and efficacy. Overall, the findings provide valuable information for further development and optimization of potential antimalarial drugs.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142868086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"One-Pot Multicomponent Synthesis of Substituted 1,6-Naphthyridine Derivatives Employing 4-Aminocumarin","authors":"Elham Ezzatzadeh, Mahsa Hojjati, Azadeh Parhami, Zinatossadat Hossaini","doi":"10.1002/aoc.7718","DOIUrl":"https://doi.org/10.1002/aoc.7718","url":null,"abstract":"<div>\u0000 \u0000 <p>This study synthesized 1,6-naphthyridine as a novel class of fused heterocyclic compounds with high efficiency using a multicomponent reaction. The reaction involved benzaldehyde or its derivatives, 2 mol of malononitrile, and 4-aminocumarin in an aqueous solution at room temperature in the presence of SiO<sub>2</sub>/Fe<sub>3</sub>O<sub>4</sub>@MWCNTs as a recyclable catalyst. This study examines the antioxidant properties of 1,6-naphthyridine in addition to the other research undertaken in this work. The production process of 1,6-naphthyridine demonstrated several advantageous features, including rapid reactions, high yields of the final product, and straightforward separation of the catalyst and product from the reaction mixture.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"38 12","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142596185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Na Chen, Yuan Li, Yang Pan, Haozhe Wang, Hao Gu, Yuan Sun, Tiedong Sun
{"title":"H2O2 Self-Supplying CaO2/POM@MOF Bimodal Nanogeneration Materials for Photothermal and Chemodynamic Synergistic Antimicrobials","authors":"Na Chen, Yuan Li, Yang Pan, Haozhe Wang, Hao Gu, Yuan Sun, Tiedong Sun","doi":"10.1002/aoc.7788","DOIUrl":"https://doi.org/10.1002/aoc.7788","url":null,"abstract":"<div>\u0000 \u0000 <p>The emergence of bacterial resistance has a negative impact on the conventional antimicrobial treatments, and research into the development of the new antimicrobial materials is of great significance. Multimodal synergistic antimicrobial materials exert better antimicrobial effects compared with a single modality. In recent years, Polyoxometalate (POM) has shown great potential in the biomedical field due to its high catalytic activity and high photothermal conversion ability. However, owing to its small surface area, its applications have been greatly limited. Herein, we designed a H<sub>2</sub>O<sub>2</sub> self-supplied CDT and PTT bimodal nanogeneration material (i.e., CaO<sub>2</sub>/POM@MOF) possessing a larger surface area for the treatment of the bacterial infections, in which CaO<sub>2</sub> could release O<sub>2</sub> and H<sub>2</sub>O<sub>2</sub> in the weakly acidic microenvironment of bacterial infection and the dual catalytic site of POM@MOF could enhance the CDT reaction to generate ROS, resulting in the bacterial oxidative stress and the leakage of the bacterial contents, and the exposure to the NIR light generates localized high temperature that cause the rupture of bacterial cell membranes and the denaturation of their proteins. Meanwhile, the superior stability of POM@MOF can release fewer metal ions to improve its biocompatibility. The in vitro antimicrobial experiments demonstrated that CaO<sub>2</sub>/POM@MOF possessed the combined CDT and PTT effect and exhibited excellent antimicrobial efficacy. This work presents a promising strategy to combat the bacterial infections.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}