Applied Organometallic Chemistry最新文献

{"title":"RETRACTION: Synthesis, Characterization and Anticancer Activity of New Palladacycles Derived From Chiral α-Diimines","authors":"","doi":"10.1002/aoc.70619","DOIUrl":"https://doi.org/10.1002/aoc.70619","url":null,"abstract":"<p><b>RETRACTION</b>: S. Cruz, S. Bernès, P. Sharma, R. Vazquez, G. Hernández, R. Portillo and R. Gutiérrez, “Synthesis, Characterization and Anticancer Activity of New Palladacycles Derived From Chiral α-Diimines,” <i>Applied Organometallic Chemistry</i> 24, no. 1 (2010): 8-11, https://doi.org/10.1002/aoc.1570.</p><p>The above article, published online on 06 November 2009 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, David Morales-Morales; and John Wiley &amp; Sons, Ltd. The retraction has been agreed upon following concerns raised by a third party. An investigation identified the reuse of cisplatin positive control data from an earlier study without appropriate attribution, which was also used across multiple other published articles. Additionally, inconsistencies were identified between the description of the positive control reported in the Experimental section and that described in the Results. The authors were contacted for comments but were unable to provide the original supporting data or a satisfactory explanation to resolve these concerns. As a result, the editors no longer have confidence in the reliability of the findings reported in this article. The author, S. Bernès, agrees with the retraction; all other authors disagree.</p>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"40 7","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aoc.70619","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148324579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Red Emitter for OLEDs Based on Bis(8-hydroxyquinoline) Zinc Complex With Styryl π-Conjugation and a Cyano Group","authors":"Beata Derkowska-Zielinska,&nbsp;Monika Pokladko-Kowar,&nbsp;Iulia E. Brumboiu,&nbsp;Anna Kaczmarek-Kedziera,&nbsp;Vitaliy Smokal,&nbsp;Anastasiia Krupka,&nbsp;Fazal Wahab,&nbsp;Zacaria Essaidi,&nbsp;Ewa Gondek","doi":"10.1002/aoc.70615","DOIUrl":"https://doi.org/10.1002/aoc.70615","url":null,"abstract":"<div>\u0000 \u0000 <p>A zinc complex based on bis(8-hydroxyquinoline) ligands containing styryl moiety with an electron-withdrawing cyano substituent (ZnStq_CN) was synthesized and used as a light-emitting dopant in a poly(9-vinylcarbazole) (PVK) matrix for an organic light-emitting diode (OLED) using the spin-coating method. The cyano group was introduced to enhance intramolecular charge transfer and modulate the electronic structure of the complex. Photophysical studies confirmed enhanced charge transfer character compared with conventional Zn(8-hydroxyquinolinate) derivatives. OLED devices based on ZnStq_CN:PVK emissive layer exhibited intense red electroluminescence centered at 620 nm with a full width at half maximum of 59 nm. The device achieved a maximum brightness of 1779 cd/m², a current efficiency of 0.97 cd/A, a turn-on voltage of 5.63 V, and a threshold voltage of 7.01 V. Compared with unsubstituted analogs, the cyano-functionalized complex demonstrated higher luminance, reduced power consumption, improved red color purity, and enhanced operational stability. Theoretical DFT calculations provide insight into the interaction and nature of excited states. These results demonstrate that electron-withdrawing substitution in Zn-quinolinate complexes is an effective strategy for tuning the emission characteristics and optimizing the efficiency of red-emitting OLEDs.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"40 7","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148324015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lewis Acid Enhanced Dioxygen Activation by Iron (II) Complex for Short- to Middle-Length Aliphatic Aldehyde Oxidations to the Corresponding Acids","authors":"Meng Gao,&nbsp;Xiachang Liu,&nbsp;Xianming Xu,&nbsp;Zhichao Wang,&nbsp;Yongjun Zhang,&nbsp;Guangjian Liao,&nbsp;Jincheng Liu,&nbsp;Chen Li,&nbsp;Ying Xin,&nbsp;Yulong Wang,&nbsp;Guochuan Yin","doi":"10.1002/aoc.70616","DOIUrl":"https://doi.org/10.1002/aoc.70616","url":null,"abstract":"<div>\u0000 \u0000 <p>Efficient catalytic oxidation through dioxygen activation under gentle conditions is a long-standing challenge in industry. The present work introduces a catalytic oxidation of short- to middle-length aliphatic aldehydes to the corresponding acids through Lewis acid enhanced dioxygen activation by iron (II) complex. It was found that the presence of a modest Lewis acid such as Ca (OTf)₂ could substantially improve the catalytic efficiency, and an unusual odd-even effect in catalysis was observed for the corresponding acid formation. The quenching experiments with 1,4-benzoquinone indicated that the iron (III) superoxo species, which is the primary active oxygen species after dioxygen activation, was one of the key active oxygen species for the oxidation. The promotional effect of Ca (OTf)₂ was attributed to its electrostatic interaction with the iron (III) superoxo species, that is, LFe^III-O₂^-•···Ca²⁺, which stabilized this intermediate, thus drove dioxygen activation to its formation and improved the catalysis. A simplified mechanism was proposed to rationalize this Lewis acid enhanced dioxygen activation by iron (II) complex for aliphatic aldehyde oxidations to the corresponding acids.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"40 7","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148282418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and Catalytic Performance of a Novel Ruthenium (II) PNN Pincer Complex Containing a Bipyridine Ring in Olefin Oxidation","authors":"Jing Liu,&nbsp;Lulu Zhang,&nbsp;Kai Zeng,&nbsp;Chunjian Qi,&nbsp;Jing Shi","doi":"10.1002/aoc.70613","DOIUrl":"https://doi.org/10.1002/aoc.70613","url":null,"abstract":"<div>\u0000 \u0000 <p>A novel ruthenium (II) PNN pincer complex (Ru-1) containing a bipyridine ring was designed and synthesized in this study, and its performance as a homogeneous catalyst in olefin oxidation reactions was systematically investigated. Raw materials were prepared via Schlenk technique, and ligand L₁ as well as the target complex Ru-1 were synthesized through multi-step reactions. The structure of Ru-1 was characterized by ¹H NMR, ³¹P NMR, high-resolution mass spectrometry (HR-MS), and X-ray crystallography, which confirmed the configuration of Ru-1. Catalytic performance studies showed that Ru-1 exhibited excellent catalytic activity and stability in styrene oxidation: when the catalyst dosage was as low as 1.00 × 10⁻⁷ mol%, 100% conversion could still be achieved, with a turnover number (TON) exceeding 1.0 × 10⁹ and a maximum turnover frequency (TOF) reaching 5.0 × 10⁷ h⁻¹. Using H₅IO₆ as the oxidant and ethyl acetate/water (1:1) as the mixed solvent, the selectivity for benzaldehyde was up to 99.0% at room temperature, which effectively suppressed side reactions. In addition, this catalyst had broad substrate compatibility and could efficiently catalyze the oxidation of styrene derivatives, internal olefins, alkynes, and natural products with a styrene structure, generating the corresponding aldehydes and ketones, respectively. This study provides an efficient and green catalytic system for the selective oxidation of olefins, highlighting the application value of bipyridine-based PNN ligands in the field of organometallic catalysis.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"40 7","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148282419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel and Eco-Friendly Cellulose@Clay/TiO2 Bio-Nanocomposite Based on Sesame Wastes for Antibacterial Application Under Visible Light","authors":"Atena Naeimi,&nbsp;Fereshteh Ezzati Ghadi,&nbsp;Sara Aghaeipoor Hasanalidehi,&nbsp;Marziyeh Mohammadi,&nbsp;Zahra Ghasempour","doi":"10.1002/aoc.70614","DOIUrl":"https://doi.org/10.1002/aoc.70614","url":null,"abstract":"<div>\u0000 \u0000 <p>A novel nanocomposite based on agricultural wastes was obtained. The adding of green TiO₂ nanoparticles to clay and natural cellulose, cellulose@clay/TiO₂ nanocomposite, was gained. This nanocomposite was characterized using ICP, FT-IR, UV, and XRD techniques. The nanocomposite was analyzed by FT-IR, SEM, TEM, XRD, UV–Vis spectroscopy, DLS, zeta potential analysis, atomic absorption spectroscopy, and elemental analysis. XRD analysis successfully confirmed the presence of cellulose, TiO₂, and clay in the nanocomposite structure. In contrast, elemental analysis confirmed the existence of Si, C, O, Al, Al₂O₃, and Ti (TiO₂), which confirmed the successful synthesis of the nanocomposite. Moreover, based on antibacterial activities, the disc diffusion method and growth percentage inhibition were determined under visible-light and dark conditions. The disc diffusion assay revealed the antibacterial activity of the nanocomposite on Gram-positive strains, especially in the presence of visible light illumination. In this study, in addition, the inhibition of Gram-positive and Gram-negative strains by the new nanocomposite and the antibacterial activity of the cellulose@clay/TiO₂ nanocomposite were confirmed. As a result, the environmentally compatible nanocomposite showed much more effective deterrence of the growth ability of Gram-positive bacteria than Gram-negative strains under visible light conditions.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"40 7","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148282665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dimethyltin(IV) Dichloride Derivatives of 4-N-Diethylaminosalicylaldimine Schiff Bases: Synthesis, Crystal Structures, Biological Activities, and Photophysical Properties","authors":"Darakhshan Parveen,&nbsp;Saumya Singh,&nbsp;Avadhesh Pratap Singh,&nbsp;Alok Kumar Verma,&nbsp;Akash Shrivastav,&nbsp;Shrishila N. Unki,&nbsp;Gurushantappa Kadakol","doi":"10.1002/aoc.70610","DOIUrl":"https://doi.org/10.1002/aoc.70610","url":null,"abstract":"<div>\u0000 \u0000 <p>Five new dimethyltin(IV) addition complexes with the general formula [SnMe₂Cl₂(HL^<b>1–5</b>)₂] (<b>HSR 1–5</b>) were synthesized via a 1:2 M reaction between dimethyltin(IV) dichloride and a series of 4-N-diethylaminosalicylaldimine Schiff bases. The ligands employed were HL^<b>1</b> = 4-N-diethylaminosalicylidene-1-aminobenzene, HL^<b>2</b> = 4-N-diethylaminosalicylidene-2-methyl-1-aminobenzene, HL^<b>3</b> = 4-N-diethylaminosalicylidene-3-methyl-1-aminobenzene, HL^<b>4</b> = 4-N-diethylaminosalicylidene-4-methyl-1-aminobenzene, and HL^<b>5</b> = 4-N-diethylaminosalicylidene-2,4,6-trimethyl-1-aminobenzene. The complexes were characterized by FT-IR, (¹H, ¹³C, and¹¹⁹Sn) NMR, HRMS spectroscopy and elemental analysis (C, H, N, Cl, and Sn). The molecular structures of <b>HSR 1</b>, <b>HSR 2</b>, <b>HSR 4</b>, and <b>HSR 5</b> were elucidated by single-crystal X-ray diffraction. All these complexes feature a Sn(IV) center in a distorted octahedral geometry, where the six coordination sites are occupied by two trans chloride ions, two trans methyl groups, and two trans oxygen atoms derived from the Schiff base ligand. The structural analysis reveals that the tin atom exhibits an all-trans octahedral coordination geometry, with the two 4-N-diethylaminosalicylaldimine Schiff base ligands binding through their phenolic oxygen atoms as iminium–phenolato zwitterions. The complexes exhibited moderate antibacterial activity against all tested strains, including <i>E. coli</i>, <i>P. aeruginosa</i>, <i>S. aureus</i>, and <i>S. pyogenes</i>, with MIC values ≥ 200 μg/mL. Activity against the fungal strains <i>C. albicans</i> and <i>A. niger</i> was also assessed. DNA cleavage studies (agarose gel electrophoresis) exhibited that the complexes possess significant potency to cleave DNA. Their photophysical properties were also investigated, and UV–Vis absorption and fluorescence measurements provided insight into the electronic behavior of the complexes, with complex HSR 1 showing the highest fluorescence intensity.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"40 7","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148282142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, Electrochemistry, In Vitro Antiprotozoal Efficacy and Mechanistic Study of Novel ‘Ferrantoin’ and Related Derivatives","authors":"Maryna Saayman,&nbsp;Janine Aucamp,&nbsp;Helena D. Janse van Rensburg,&nbsp;Christina Kannigadu,&nbsp;Rotondwa Mphephu,&nbsp;Andrew J. Swarts,&nbsp;Keisuke Suganuma,&nbsp;David D. N'Da","doi":"10.1002/aoc.70606","DOIUrl":"https://doi.org/10.1002/aoc.70606","url":null,"abstract":"<p>African trypanosomiasis and leishmaniasis are vector-borne infectious diseases that affect both humans and animals. If left untreated, these neglected tropical diseases can be fatal. There are tens to thousands of new cases of both diseases reported by the WHO annually. The clinically available treatments are not practical because they suffer from severe adverse effects, impractical administration and increased instances of parasitic resistance. This emphasises the need for the development of new drugs to treat these diseases. In the search for such drugs, we investigated a series of ferrocenyl-based hydantoin/rhodanine derivatives. Herein, we report the design, synthesis, electrochemistry and in vitro biological activity of these derivatives against amastigotes of <i>Leishmania donovani</i>, as well as blood-stage trypomastigotes of <i>Trypanosoma brucei brucei</i>, <i>Trypanosoma brucei gambiense</i>, <i>Trypanosoma brucei rhodesiense</i>, <i>Trypanosoma equiperdum</i> and <i>Trypanosoma evansi</i>. Ferrocenylrhodanine analogues <b>19</b> and <b>23</b> were identified as a potential leishmanicidal early lead and hit, respectively, whereas 3-hydantoin-containing analogue <b>11</b> was identified as an antileishmanial hit. Ferrocene derivatives <b>23</b> and <b>11</b> were tested for ROS activity, and mitochondrial dysfunction is suspected to play a role in their mechanisms of action. Nine trypanosomacidal hits were also identified, of which ferrocenylrhodanine analogue <b>21</b> was the most prominent. These compounds are accordingly suited for further investigation as antitrypanosomatid drugs in the future. This may include increasing compound stability and solubility.</p>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"40 7","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aoc.70606","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148238041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 3D Terbium-Porphyrin Framework for Visible-Light-Driven Singlet Oxygen Generation and Photocatalytic Oxidation","authors":"Danhui Zhao,&nbsp;Jishi Chen,&nbsp;Chuantao Hou","doi":"10.1002/aoc.70612","DOIUrl":"https://doi.org/10.1002/aoc.70612","url":null,"abstract":"<div>\u0000 \u0000 <p>Elucidating the structural evolution of secondary building units (SBUs) in lanthanide-porphyrin frameworks (Ln-PMOFs) remains a compelling challenge in targeted crystal engineering. Herein, a novel 3D framework, QPF-13, featuring unique intermediate-nuclearity Tb₃ and Tb₄ clusters, was synthesized from Tb (III) and tetrakis(3-carboxyphenyl)porphyrin. Significantly, QPF-13 bridges the structural gap between previously established low-nuclearity (Ln₂) and high-nuclearity (Ln₇/Ln₉) extremes, successfully completing the SBU evolutionary landscape within this systematic series. Furthermore, the rigid spatial confinement of the porphyrin macrocycles effectively suppresses self-quenching, enabling robust visible-light-driven singlet oxygen generation. Consequently, QPF-13 demonstrates excellent photocatalytic performance in the selective oxidation of 1,5-dihydroxynaphthalene. This work provides deep crystallographic insights into Ln-coordination assembly and establishes a rational structural library for designing advanced photooxidation catalysts.</p>\u0000 </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"40 7","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148237712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Green Synthesis of Silver Nanoparticles Using Water Extract of Salvia leriifolia: Antibacterial Studies and Applications as Catalysts in the Electrochemical Detection of Nitrite","authors":"","doi":"10.1002/aoc.70611","DOIUrl":"https://doi.org/10.1002/aoc.70611","url":null,"abstract":"<p><b>RETRACTION</b>: M. Baghayeri, B. Mahdavi, Z. H.-M. Abadi, and S. Farhadi, “Green Synthesis of Silver Nanoparticles Using Water Extract of <i>Salvia leriifolia</i>: Antibacterial Studies and Applications as Catalysts in the Electrochemical Detection of Nitrite,” <i>Applied Organometallic Chemistry</i> 32, no. 2 (2018): e4057. https://doi.org/10.1002/aoc.4057.</p><p>The above article, published online on 25 September 2017 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, David Morales-Morales; and John Wiley &amp; Sons Ltd. A third party reported that the TEM image in Figure 5B contained multiple duplicated areas. These concerns were confirmed by the publisher. In addition, multiple concerns were raised regarding impossible, contradictory, and unexplained details in the articles’ Experimental section.</p><p>The authors responded to an inquiry by the publisher and reported that the TEM experiments were outsourced and that the duplicated sections in the image may be due to artifacts introduced during scanning. After multiple requests, the authors did not provide a response to the further concerns noted in the Experimental section and did not supply original data as requested.</p><p>The retraction has been agreed to because the evidence of image manipulation in Figure 5B, as well as multiple unexplained errors or questionable details in the Experimental section, fundamentally compromise the editors’ confidence in the results presented in the article. The authors did not respond to our notice regarding the retraction.</p>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"40 7","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aoc.70611","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148237684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenylbenzothiazole Bis(Cyclometalated) Pt(IV) Complexes With Phenanthroline-Based Ligands as ROS, NADH and Microtubule Destabilizing Agents","authors":"Andrea Corral-Zorzano,&nbsp;David Gómez de Segura,&nbsp;Icíar P. López,&nbsp;José G. Pichel,&nbsp;Elena Lalinde,&nbsp;M. Teresa Moreno","doi":"10.1002/aoc.70604","DOIUrl":"https://doi.org/10.1002/aoc.70604","url":null,"abstract":"<p>Pt(IV) complexes have garnered extensive attention in relation to their optical properties and biological activity. Herein, we report a new series of luminescent cationic cyclometalated Pt(IV) complexes with phenanthroline-type ligands [Pt(pbt)₂(N^N)](ClO₄)₂ (pbt = phenylbenzothiazole; N^N = phen <b>2</b>, pyraphen <b>3</b>, NH₂-phen <b>4</b>), obtained from [Pt(pbt)₂Cl₂] (<b>1</b>), and their biological activity. Complexes <b>2</b> and <b>3</b> showed orange emissions, attributed to a ³IL (pbt) excited state, whereas complex <b>4</b> showed dual emission arising from closely lying ³IL′CT/³L′LCT (L′ = NH₂-phen) states, as confirmed by DFT calculations. Upon blue light irradiation, complexes <b>1</b> and <b>4</b> generated ¹O₂ and catalyzed NADH photooxidation. Spectroscopic studies indicated BSA binding for complexes <b>2</b> and <b>4</b>. Among the series, complex <b>4</b> exhibited the highest anticancer cytotoxic activity, comparable to cisplatin, and <b>1</b>–<b>3</b> showed mild phototoxicity. Complex <b>4</b> generated intracellular ROS production, microtubule depolymerization and mitochondrial damage in A549 cells, without DNA interaction.</p>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"40 7","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/aoc.70604","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148174480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}