Archives of Physiology and Biochemistry最新文献_第4页

Clinical value of serum LINC00240 and its role in lipid metabolism of non-alcoholic fatty liver disease. 血清LINC00240的临床价值及其在非酒精性脂肪肝脂质代谢中的作用

IF 3.2 4区医学

Archives of Physiology and Biochemistry Pub Date : 2026-07-23 DOI: 10.1080/13813455.2026.2699140

Baijing Yang, Yuan Gan, Hongchun Zhu, Shihong Lv, Tao Tan, Xin Jiang

{"title":"Clinical value of serum LINC00240 and its role in lipid metabolism of non-alcoholic fatty liver disease.","authors":"Baijing Yang, Yuan Gan, Hongchun Zhu, Shihong Lv, Tao Tan, Xin Jiang","doi":"10.1080/13813455.2026.2699140","DOIUrl":"https://doi.org/10.1080/13813455.2026.2699140","url":null,"abstract":"Background: Long non-coding RNAs (lncRNAs) play pivotal roles in diverse diseases, including non-alcoholic fatty liver disease (NAFLD). This study aimed to explore the expression of LINC00240 in NAFLD patients, elucidating its potential as a biomarker.Methods: RT-qPCR was employed to measure the levels of LINC00240 and miR-133a-3p. ROC curve analysed diagnostic value, luciferase reporter assay verified their targeting relationship, and lipid metabolism markers were detected for correlation analysis.Results: Serum LINC00240 was upregulated and miR-133a-3p was downregulated in NAFLD patients. LINC00240 was positively correlated with TC, TG, ALT, and HOMA-IR. Both LINC00240 and miR-133a-3p displayed diagnostic potential. LINC00240 directly targeted miR-133a-3p. Knockdown of LINC00240 reduced lipid metabolism parameters, while was partially reversed by miR-133a-3p antagomir.Conclusion: LINC00240 and miR-133a-3p are potential diagnostic biomarkers for NAFLD. LINC00240/miR-133a-3p axis modulates NAFLD progression by regulating hepatic steatosis and insulin resistance, suggesting an antagonistic regulatory mechanism underlying NAFLD progression and lipid metabolic dysregulation.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-11"},"PeriodicalIF":3.2,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148560744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations of reproductive history with cognitive impairment, depression, and anxiety in older women: a cross-sectional analysis of the CLHLS combined with Mendelian randomization. 老年妇女生殖史与认知障碍、抑郁和焦虑的关系：CLHLS结合孟德尔随机化的横断面分析

IF 3.2 4区医学

Archives of Physiology and Biochemistry Pub Date : 2026-07-23 DOI: 10.1080/13813455.2026.2699139

Wei Chen, Yanliang Li, Shurun Wan, Kangning Zhou, Yuyao He, Wenyue Hu, Zhenyun Han

{"title":"Associations of reproductive history with cognitive impairment, depression, and anxiety in older women: a cross-sectional analysis of the CLHLS combined with Mendelian randomization.","authors":"Wei Chen, Yanliang Li, Shurun Wan, Kangning Zhou, Yuyao He, Wenyue Hu, Zhenyun Han","doi":"10.1080/13813455.2026.2699139","DOIUrl":"10.1080/13813455.2026.2699139","url":null,"abstract":"Background: With rapid global population ageing, older women bear a disproportionate burden of cognitive impairment, depression, and anxiety. Reproductive history, a unique and irreversible life course factor, may influence late-life cognitive and mental health.Methods: We included 4,173 women aged ≥65 years from the 2017-2018 China Longitudinal Healthy Longevity Survey. Standard scales assessed cognition and mood, followed by regression, network, and two-sample MR analyses.Results: After adjustment, having more than four births was associated with a lower risk of cognitive impairment (OR = 0.66, 95% CI: 0.48-0.91). Network analysis identified restlessness and uncontrollable worry as central symptoms, with language and attention as key bridge nodes. MR analyses linked higher parity to poorer cognition and later first birth to better cognition and lower depression risk.Conclusion: Reproductive history is linked to late-life cognitive and emotional health through sociocultural and biological mechanisms, highlighting the importance of population-specific precision health strategies.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-15"},"PeriodicalIF":3.2,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148560636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

E-DCNNBAE: design of a novel segmentation and classification approach for brain tumour prediction. E-DCNNBAE：一种新的脑肿瘤预测分割和分类方法的设计。

IF 3.2 4区医学

Archives of Physiology and Biochemistry Pub Date : 2026-07-22 DOI: 10.1080/13813455.2026.2699191

Manavi Sharma, Karan Veer

{"title":"E-DCNNBAE: design of a novel segmentation and classification approach for brain tumour prediction.","authors":"Manavi Sharma, Karan Veer","doi":"10.1080/13813455.2026.2699191","DOIUrl":"https://doi.org/10.1080/13813455.2026.2699191","url":null,"abstract":"Context: Health plays an essential role in human life, particularly brain health, which supports vital system functions. Magnetic Resonance Imaging (MRI) is a crucial tool for diagnosing brain-related disorders and provides large datasets suitable for artificial intelligence, especially image classification. Objective: The aim of this study is to develop an accurate and reliable deep learning-based framework for the automatic classification of brain tumours (glioma, meningioma, and pituitary tumours) from MRI images. Materials and methods: Pre-processing is performed using the Adaptive Contrast Enhancement Algorithm (ACEA) and a median filter. For segmentation, Weighted Fuzzy C-means clustering (WFCMC) ensures reliable pixel assessment, normalisation, and generalisation. Image regularisation is achieved by scaling and analysing data loss to maintain pixel stability. A novel Ensembling Dense Convolutional Neural Network with Bayesian Auto-encoder (E-DCNNBAE) model is proposed for classification. Results: The performance of model is evaluated using accuracy, precision, recall, F-score, and AUC. It achieves 97% accuracy, 99% precision, 98% recall, 98% F-score, and 98% AUC. Conclusion: This study improving early diagnosis and treatment of brain diseases.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-19"},"PeriodicalIF":3.2,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148547686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondrial DNA copy number in diabetic kidney disease: translational prospects and challenges. 线粒体DNA拷贝数在糖尿病肾病中的翻译前景和挑战。

IF 3.2 4区医学

Archives of Physiology and Biochemistry Pub Date : 2026-07-19 DOI: 10.1080/13813455.2026.2702001

Lixia Lu, Yongtong Cao, Liang Ma, Xiaomu Kong

{"title":"Mitochondrial DNA copy number in diabetic kidney disease: translational prospects and challenges.","authors":"Lixia Lu, Yongtong Cao, Liang Ma, Xiaomu Kong","doi":"10.1080/13813455.2026.2702001","DOIUrl":"https://doi.org/10.1080/13813455.2026.2702001","url":null,"abstract":"Context: Diabetic kidney disease (DKD) presents substantial challenges in early detection and clinical monitoring. Mitochondrial dysfunction plays a pivotal role in DKD pathogenesis, and mitochondrial DNA copy number (mtDNA-CN) reflects this dysfunction. Objective: To evaluate the translational potential of mtDNA-CN as a biomarker for DKD, focusing on its diagnostic, prognostic, and monitoring utility across biological specimens, and examine the critical challenges of its clinical translation. Materials and Methods: We systematically synthesize evidence from cellular experiments, animal models, and clinical studies that assess mtDNA-CN alterations in DKD, with a comparative analysis of specimen types and methodologies. Results: Studies demonstrated that mtDNA-CN in blood and urine are correlated with the onset and progression of DKD. Rigorous standardization must be implemented across specimen collection, pre-analytical processing, analytical testing, detection and data reporting. Conclusion: MtDNA-CN is a promising and measurable biomarker for DKD. Combined with conventional markers, it could enhance clinical utility.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-29"},"PeriodicalIF":3.2,"publicationDate":"2026-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148519691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Meta-Analysis of DNA methylation and gut microbiome data in preterm birth reveals epigenetic and microbial biomarkers for early diagnosis and probiotic-based intervention. DNA甲基化和肠道微生物组数据的荟萃分析揭示了早期诊断和基于益生菌的干预的表观遗传和微生物生物标志物。

IF 3.2 4区医学

Archives of Physiology and Biochemistry Pub Date : 2026-07-17 DOI: 10.1080/13813455.2026.2699137

Lingli Li, Chunyan Wang, Chunyan Liu, Yuru Dong

{"title":"Meta-Analysis of DNA methylation and gut microbiome data in preterm birth reveals epigenetic and microbial biomarkers for early diagnosis and probiotic-based intervention.","authors":"Lingli Li, Chunyan Wang, Chunyan Liu, Yuru Dong","doi":"10.1080/13813455.2026.2699137","DOIUrl":"https://doi.org/10.1080/13813455.2026.2699137","url":null,"abstract":"Background: Globally, preterm birth continues to be a major contributor to neonatal morbidity and mortality. Developing early diagnostics and focused interventions requires an understanding of the molecular and microbiome factors causing preterm birth and also the identification of biomarkers. Methods: We integrated gut microbiome and DNA methylation data to identify biomarkers of preterm birth. Analysis of GSE120458 revealed 1,609 differentially methylated regions involved in immune, hormonal, and neurodevelopmental pathways. Microbiome profiling identified five altered genera: Faecalibacterium prausnitzii, Streptococcus, Blautia faecis, Gemella, and Agathobacter. Taxon Set Enrichment Analysis revealed that these genera were found to be associated with systemic diseases like diabetes, obesity, and inflammatory bowel disease. Results: We identified 1,649 genes targeted by 33 microbial metabolites, with 17 overlapping methylated genes indicating microbiome-epigenome interactions. These genes were linked to neuroimmune and synaptic pathways. Conclusion: Hub genes may serve as biomarkers for early intervention. Overall, the results connect microbial metabolism with epigenetic regulation in preterm birth.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-13"},"PeriodicalIF":3.2,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148468612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protein-guided regulation of redox metabolic imbalance improves survival physiology in acute respiratory distress syndrome. 蛋白质引导的氧化还原代谢失衡调节改善急性呼吸窘迫综合征的生存生理学。

IF 3.2 4区医学

Archives of Physiology and Biochemistry Pub Date : 2026-07-17 DOI: 10.1080/13813455.2026.2701306

Hongyu Luo, Zhenzhi Zhao, Meizhi Deng

{"title":"Protein-guided regulation of redox metabolic imbalance improves survival physiology in acute respiratory distress syndrome.","authors":"Hongyu Luo, Zhenzhi Zhao, Meizhi Deng","doi":"10.1080/13813455.2026.2701306","DOIUrl":"https://doi.org/10.1080/13813455.2026.2701306","url":null,"abstract":"Background: Acute Respiratory Distress Syndrome (ARDS) is a life-threatening condition associated with high morbidity and mortality, characterized by severe inflammation, oxidative stress, impaired gas exchange, and progressive lung injury. Disruption of cellular redox homeostasis plays a central role in ARDS pathogenesis, making redox-regulatory mechanisms attractive therapeutic targets. Methods: This review evaluates experimental evidence on protein-mediated regulation of oxidative stress pathways in ARDS, focusing on proteins involved in antioxidant defense, reactive oxygen species (ROS) generation, mitochondrial signaling, and maintenance of cellular redox homeostasis. Results: Current evidence indicates that key regulatory proteins modulate oxidative stress by activating endogenous antioxidant defense systems, regulating ROS production, and influencing mitochondrial signaling pathways. These mechanisms reduce oxidative damage and pulmonary inflammation while preserving cellular redox balance. Experimental studies further demonstrate that modulation of specific protein regulators enhances cellular resilience under hypoxic and inflammatory conditions characteristic of ARDS. Conclusions: Protein-mediated regulation of redox signaling represents a promising therapeutic strategy for ARDS. Targeting redox-regulatory proteins may attenuate oxidative stress, reduce lung inflammation, and improve cellular survival, supporting their potential as novel therapeutic targets. Further preclinical and clinical studies are needed to validate these findings and facilitate their translation into clinical practice.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-15"},"PeriodicalIF":3.2,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148468625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exosomes derived from human umbilical cord mesenchymal stem cells attenuate brain-lung complications in type 2 diabetic rats via suppression of mTOR/GSK3β and TRPM2/NLRP3 pathways. 来自人脐带间充质干细胞的外泌体通过抑制mTOR/GSK3β和TRPM2/NLRP3通路减轻2型糖尿病大鼠脑肺并发症。

IF 3.2 4区医学

Archives of Physiology and Biochemistry Pub Date : 2026-07-13 DOI: 10.1080/13813455.2026.2700015

Marwa Abdeltawab Mohammed, Rowayda Mohamed Ahmed, Heba Ahmed Hashem, Sahar Mohamed Mostafa, Khadiga Mahmoud Moustafa, Sherif Faysal Abdelfattah, Alshimaa Mohamed Abdelmohymen

{"title":"Exosomes derived from human umbilical cord mesenchymal stem cells attenuate brain-lung complications in type 2 diabetic rats via suppression of mTOR/GSK3β and TRPM2/NLRP3 pathways.","authors":"Marwa Abdeltawab Mohammed, Rowayda Mohamed Ahmed, Heba Ahmed Hashem, Sahar Mohamed Mostafa, Khadiga Mahmoud Moustafa, Sherif Faysal Abdelfattah, Alshimaa Mohamed Abdelmohymen","doi":"10.1080/13813455.2026.2700015","DOIUrl":"10.1080/13813455.2026.2700015","url":null,"abstract":"Diabetes mellitus is associated with neurochemical and lung imbalances. This study investigates the therapeutic potential of exosome (Exo) treatment in ameliorating systemic complications in a rat model of type 2 diabetes. Eighteen male rats were divided into three groups: Control, Diabetic, and Diabetic + Exosome-treated. After the intervention period, serum, brain, and lung tissues were analysed. In serum, diabetes induced hyperglycaemia and dyslipidaemia, all of which were significantly improved by Exo (p < 0.001). Diabetic rats exhibited significant elevations in brain malondialdehyde, mTOR, and GSK3β, along with reduced glutathione, serotonin, and dopamine (all p < 0.001 vs. Control). Exo treatment reversed these changes (p < 0.001 vs. Diabetic). In lung tissue, diabetes increased MDA, TRPM2, and NLRP3 while suppressed superoxide dismutase; Exo treatment ameliorated these issues (p < 0.001). Exosomes exert potent antioxidant and anti-inflammatory in type 2 diabetic rats in the brain and lungs.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-19"},"PeriodicalIF":3.2,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148434938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation between traditional Chinese medicine syndromes of gastro oesophageal reflux disease and high-resolution esophageal manometry findings a cross-sectional study. 胃食管反流病中医证候与高分辨率食管测压的相关性横断面研究

IF 3.2 4区医学

Archives of Physiology and Biochemistry Pub Date : 2026-07-13 DOI: 10.1080/13813455.2026.2699134

Yanmei Cai, Qiaoyan Zhang, Jinming Song, Baotuan Zhao, Naiwei Zhang

{"title":"Correlation between traditional Chinese medicine syndromes of gastro oesophageal reflux disease and high-resolution esophageal manometry findings a cross-sectional study.","authors":"Yanmei Cai, Qiaoyan Zhang, Jinming Song, Baotuan Zhao, Naiwei Zhang","doi":"10.1080/13813455.2026.2699134","DOIUrl":"10.1080/13813455.2026.2699134","url":null,"abstract":"Background: This multicentre study examined the association between TCM syndromes and HRM parameters in GERD patients. Methods: GERD patients were classified into seven syndromes and assessed for LESP, LESL, IRP, DL, DCI, IEM, and fragmented peristalsis. Results: HRM parameters differed significantly among TCM syndromes (p < 0.01). Liver-Stomach Depression Heat (28.3%, 128/452) and Gallbladder Heat Attacking Stomach (12.4%, 56/452) showed higher LESP (18.5 ± 4.2 and 17.8 ± 3.9 mmHg) and DCI, indicating hypermotility. Middle Deficiency with Qi Counterflow (18.1%, 82/452) and Stomach Yin Deficiency (9.3%, 42/452) showed lower LESP (9.2 ± 2.8 and 8.5 ± 2.5 mmHg) and higher IEM (68.3% and 73.8%), indicating hypomotility. Qi Depression and Phlegm Obstruction (15.0%, 68/452) correlated with fragmented peristalsis (35.3%). Blood Stasis Obstructing the Collaterals (5.8%, 26/452) showed increased IRP (11.2 ± 3.5 mmHg) and abnormal coordination, and Spleen Deficiency with Dampness-Heat was mainly hypomotile. Conclusion: TCM syndromes in GERD correspond to distinct HRM patterns.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-9"},"PeriodicalIF":3.2,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148429657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AMPK phosphorylation regulates HIIT to improve the molecular mechanism of exercise metabolic syndrome: MG53 protein molecular mechanism and exercise nutrition intervention. AMPK磷酸化调控HIIT改善运动代谢综合征的分子机制：MG53蛋白分子机制与运动营养干预

IF 3.2 4区医学

Archives of Physiology and Biochemistry Pub Date : 2026-07-06 DOI: 10.1080/13813455.2026.2699138

Ren Yong

{"title":"AMPK phosphorylation regulates HIIT to improve the molecular mechanism of exercise metabolic syndrome: MG53 protein molecular mechanism and exercise nutrition intervention.","authors":"Ren Yong","doi":"10.1080/13813455.2026.2699138","DOIUrl":"https://doi.org/10.1080/13813455.2026.2699138","url":null,"abstract":"Background: The prevalence of exercise metabolic syndrome (MetS) has prompted research on effective intervention strategies, particularly high-intensity interval training (HIIT) and its potential in combination with exercise nutrition.Purpose: The study aims to explore the specific molecular mechanism of AMPK phosphorylation regulation in improving exercise metabolic syndrome in HIIT.Method: By detecting the structural characteristics and phosphorylation status of AMPK, analyse its regulatory effect on metabolism.Results: The results showed that HIIT significantly promoted the phosphorylation of AMPK and enhanced its regulatory ability on energy metabolism. Meanwhile, the expression of MG53 protein was upregulated with the implementation of HIIT and exercise nutrition, indicating its critical role in muscle cell repair and metabolic regulation.Conclusion: Therefore, the phosphorylation regulation of AMPK plays a central role in the improvement of exercise metabolic syndrome by HIIT, and MG53 protein, as an important regulatory factor, may enhance the effectiveness of HIIT by promoting cell repair and metabolic regulation.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-8"},"PeriodicalIF":3.2,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148389503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 修正。

IF 3.2 4区医学

Archives of Physiology and Biochemistry Pub Date : 2026-06-26 DOI: 10.1080/13813455.2026.2694301

引用次数: 0