Archives of Physiology and Biochemistry最新文献_第4页

Genetic variability of the MTHFR rs1801133 gene polymorphism and role of zinc level in obese patients. 肥胖患者MTHFR rs1801133基因多态性的遗传变异性及锌水平的作用

IF 2.7 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-08-01 Epub Date: 2025-02-14 DOI: 10.1080/13813455.2025.2465338

Haider Ali Alnaji, Alkarar K Abduljaleel, Taif Al-Saadi, Abbas F Almulla

{"title":"Genetic variability of the MTHFR rs1801133 gene polymorphism and role of zinc level in obese patients.","authors":"Haider Ali Alnaji, Alkarar K Abduljaleel, Taif Al-Saadi, Abbas F Almulla","doi":"10.1080/13813455.2025.2465338","DOIUrl":"10.1080/13813455.2025.2465338","url":null,"abstract":"Background: Obesity is an increased condition arising from the combination of two factors genetic and environmental. The genetic predisposition has been shown to contribute substantially to the development of obesity.Objective: The study aimed to investigate the association of the rs1801133 SNP and trace elements in a cohort of obese patients.Methods: This case-control study looked at a total of 104 university students, 51 individuals with obesity, and 53 individuals as controls. Biochemical measurements by the colorimetric method include zinc and copper. Genetic analysis by the tetra primers ARMS-PCR was used for genotyping the rs180113 SNP in the MTHFR gene.Results: Serum zinc levels were significantly higher in the obese group compared to the non-obese group (145.1 ± 24.89 ug/dl vs. 114.8 ± 29.44 ug/dl, p = 0.0133), while copper levels showed no significant difference. Genotyping revealed the rs1801133 polymorphism in the MTHFR gene is significantly associated with obesity, with the A allele more frequent in obese individuals (39.6% vs. 14.5%, p < 0.05).Conclusion: Zn and rs1801133 are associated with obesity, the A allele of rs1801133 SNP and the significant associations observed in different genetic models highlight the potential of this polymorphism as a genetic marker for obesity risk.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"593-600"},"PeriodicalIF":2.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of herbaceous bioflavonoid herbacetin on oxidative stress, and alpha-synuclein regulation, programmed cell death in a Parkinson illness. 草本类黄酮对帕金森病患者氧化应激、α -突触核蛋白调控、程序性细胞死亡的影响。

IF 2.7 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-08-01 Epub Date: 2025-04-23 DOI: 10.1080/13813455.2025.2493103

Chinnadurai Veeramani, Mohammed A Alsaif, Muhammad Ibrar Khan, Ahmed S El Newehy, Ali Alshammari, Khalid S Al-Numair

{"title":"Effects of herbaceous bioflavonoid herbacetin on oxidative stress, and alpha-synuclein regulation, programmed cell death in a Parkinson illness.","authors":"Chinnadurai Veeramani, Mohammed A Alsaif, Muhammad Ibrar Khan, Ahmed S El Newehy, Ali Alshammari, Khalid S Al-Numair","doi":"10.1080/13813455.2025.2493103","DOIUrl":"10.1080/13813455.2025.2493103","url":null,"abstract":"Background: Herbacetin, a flavonoid present in many types of herbs, which include linaceae, ephedraceae, and crassulaceae, exhibits a range of medicinal properties. 1-methyl-4-phenylpyridinium (MPP+) is one of the neurotoxins used in cell-based Parkinson's disease (PI) models. Whereas the precise chemical mechanism of iron association with free radical cell damage and apoptosis is yet unknown, intracellular irons are a key factor for MPP+-derived apoptosis.Methods: We examine whether the antiapoptotic properties of flaxseed bioflavonoid herbacetin (HB) are associated with the stimulation of the intrinsic caspase-dependent pathway and exposing of MPP+ caused neuronal death in the human dopaminergic neuroblastoma cells. Four groups were created out of the cells. Groups I, II, III, and IV are the control, HB+MPP+, MPP+, and HB, respectively. Following a 24-hour incubation period, the cells were subjected to several parameters.Results: We discovered in neuroblastoma cells that HB dramatically reduced the cell death induced by MPP+. Additionally, HB significantly reduced the formation of ROS and counteracted the reduction in MMP resulting from MPP+ treatment. HB reduces the stimulation of the intrinsic caspase-dependent apoptotic mechanism and suppresses the MPP+-mediated apoptotic signalling pathway. Furthermore, HB predicted a better binding interaction with alpha-synuclein and drastically decreased alpha-synuclein expression and accumulation in neuroblastoma cells.Conclusion: Consequently, our findings imply that HB shields neurons by reducing oxidative stress, alpha-synuclein misfolding in neuroblastoma, and apoptosis prompts the death of neuroblastoma cells.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"701-711"},"PeriodicalIF":2.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GC-MS analysis, the in vitro and in vivo protective effect of Phlogacanthus thyrsiflorus Nees. on hyperglycaemia-induced diabetic mice model. 气相色谱-质谱（GC-MS）分析，胸草的体内外保护作用。高血糖诱导的糖尿病小鼠模型。

IF 2.7 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-08-01 Epub Date: 2025-04-04 DOI: 10.1080/13813455.2025.2483501

Jutishna Bora, Sumira Malik, Richa Mishra, Sarvesh Rustagi, Petr Slama, Smita Lata, Nayan Talukdar, Saad Alghamdi, Abdullah Aldairi, Faten Noor Habiballah, Mazen Almehmadi, Osama Abdulaziz, Naif Alsiwiehri, Seema Ramniwas

{"title":"GC-MS analysis, the in vitro and in vivo protective effect of Phlogacanthus thyrsiflorus Nees. on hyperglycaemia-induced diabetic mice model.","authors":"Jutishna Bora, Sumira Malik, Richa Mishra, Sarvesh Rustagi, Petr Slama, Smita Lata, Nayan Talukdar, Saad Alghamdi, Abdullah Aldairi, Faten Noor Habiballah, Mazen Almehmadi, Osama Abdulaziz, Naif Alsiwiehri, Seema Ramniwas","doi":"10.1080/13813455.2025.2483501","DOIUrl":"10.1080/13813455.2025.2483501","url":null,"abstract":"Objective: This study investigates the in-vitro and in-vivo antioxidant capacities showed by Phlogacanthus thyrsiflorus Nees. (P. thyrsiflorus) in alloxan-administered diabetic mice.Materials and methods: The screening of phytochemical of methanolic flower extract (MFE), Gas Chromatography Mass Spectrometry (GC-MS) profiling was utilized to identify bioactive compounds. In-vitro antioxidant studies were performed. Acute toxicity was evaluated in mice. Glucose Transporter type 4 (GLUT4) protein expression and antioxidant enzyme activities were assessed. Histopathological examination of heart tissue was performed.Results: GC-MS analysis revealed the presence of various bioactive compounds consisting of antioxidant, anti-inflammatory activities. The results also showed a noteworthy increase in in-vitro and in-vivo antioxidant enzymes activities. Moreover, MFE suppress hyperglycaemia by upregulating GLUT4 protein expression. In histological study MFE was found to restore cellular alterations in diabetic tissue.Discussion and conclusion: It is inferred from the study that MFE of P. thyrsiflorus can exert a protective effect by suppressing hyperglycaemia and modulating oxidative stress in alloxan-administered diabetic mice.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"636-647"},"PeriodicalIF":2.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of berberine in metabolic and bone changes in ovariectomized rats. 小檗碱在去卵巢大鼠代谢和骨变化中的作用。

IF 2.7 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-08-01 Epub Date: 2025-02-13 DOI: 10.1080/13813455.2025.2465360

Yasmin Mohammed Eid, Salma Elwy Nassar, Romaysaa Ali El Sherbeny, Ramez Abd-Elmoneim Barhoma

{"title":"Role of berberine in metabolic and bone changes in ovariectomized rats.","authors":"Yasmin Mohammed Eid, Salma Elwy Nassar, Romaysaa Ali El Sherbeny, Ramez Abd-Elmoneim Barhoma","doi":"10.1080/13813455.2025.2465360","DOIUrl":"10.1080/13813455.2025.2465360","url":null,"abstract":"Background: This study investigates Berberine's (BBR) impact on metabolic and bone changes in ovariectomized rats, a model for postmenopausal conditions.Methods: Sixty adult female rats divided into six groups: control, sham ovariectomized, ovariectomized, and three BBR treated ovariectomized groups (50, 100, and 200 mg/kg/day, for eight weeks). Measurements included serum oestradiol, glucose, HOMA-IR, lipid profile, tumour necrosis factor alpha (TNF-α), oxidative stress markers, osteocalcin (OC), bone-specific alkaline phosphatase (ALP), cross-linked Carboxy-terminal telopeptide of type I collagen (CTX-I), and bone tissue analysis.Results: Ovariectomized rats exhibited significant metabolic and bone deterioration, such as increased glucose, insulin, HOMA IR, total cholestrol (TC), LDL-C, TNF-α, OC, ALP, CTX-I, and MDA levels, alongside decreased oestradiol, HDL-C, and GSH levels, and DNA fragmentation (P < 0.001). BBR treatment showed dose-dependent improvements in all parameters.Conclusion: BBR demonstrates significant ameliorative effects on metabolic and bone health in ovariectomized rats, highlighting its potential therapeutic benefits for postmenopausal conditions.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"601-609"},"PeriodicalIF":2.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prediction of maximum voluntary ventilation based on forced expiratory volume in athletes. 基于运动员用力呼气量的最大自主通气预测。

IF 2.7 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-08-01 Epub Date: 2025-02-17 DOI: 10.1080/13813455.2025.2465333

Irma Lorenzo-Capellá, Juan José Ramos-Álvarez, Elena Jiménez-Herranz, Nicola Maffulli, Enzo Iuliano, Johnny Padulo, Francisco Javier Calderón-Montero

{"title":"Prediction of maximum voluntary ventilation based on forced expiratory volume in athletes.","authors":"Irma Lorenzo-Capellá, Juan José Ramos-Álvarez, Elena Jiménez-Herranz, Nicola Maffulli, Enzo Iuliano, Johnny Padulo, Francisco Javier Calderón-Montero","doi":"10.1080/13813455.2025.2465333","DOIUrl":"10.1080/13813455.2025.2465333","url":null,"abstract":"Objective: Maximum-voluntary-ventilation (MVV) is the maximal volume of which an individual can move by voluntary effort in one minute. It is possible that the first second forced-expiratory-volume (FEV1) could be more to reliable assess respiratory muscle endurance to estimate MVV.Methods: For this aim, 422 athletes (Age 22.9 ± 8.5 years; 98/324 - females/males) were performed a MVV, and FEV1 measurements.Results: The coefficient of determination was R2 = 0.594 between MVV and FEV1, with a predictive equation for overall participants: MVV = (FEV1 × 33.5)+12.7. The robust regression showed a good multiple correlation coefficient (R = 0.815) with the coefficient of determination R2 = 0.661 for the model including FEV1, age and gender as predictors. These equations MVV = (FEV1 X 27.3)+(Age(y) × 1.1)+20.5 and MVV = (FEV1 × 27.3)+(Age(y) × 1.1) were derived for male and female, respectively.Conclusion: FEV1 can predict MVV in different athletes with greater accuracy when stratified per gender. Therefore, this new approach can be used in a short all-out test without stress of the respiratory muscle to predict MVV in athletes.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"569-577"},"PeriodicalIF":2.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bee bread shows therapeutic and protective effects by alleviating inflammation, oxidative stress, and apoptosis on acetic acid-induced gastric ulcer in rats. 蜜蜂面包对醋酸诱发的大鼠胃溃疡具有治疗和保护作用，能减轻炎症、氧化应激和细胞凋亡。

IF 2.7 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-08-01 Epub Date: 2025-02-23 DOI: 10.1080/13813455.2025.2466191

Hatice Colak, Esra Tansu Sarıyer, Meral Yüksel, İlayda Özge Polat, Esra Çikler, Neslihan Öner, Berna Karakoyun

{"title":"Bee bread shows therapeutic and protective effects by alleviating inflammation, oxidative stress, and apoptosis on acetic acid-induced gastric ulcer in rats.","authors":"Hatice Colak, Esra Tansu Sarıyer, Meral Yüksel, İlayda Özge Polat, Esra Çikler, Neslihan Öner, Berna Karakoyun","doi":"10.1080/13813455.2025.2466191","DOIUrl":"10.1080/13813455.2025.2466191","url":null,"abstract":"Objective: This study investigated bee bread's (BB) protective and therapeutic effects on acetic acid-(AA)-induced gastric ulcers via oxidative stress, DNA damage, inflammation, and apoptosis.Materials and methods: Rats were administered saline-(1ml) or BB-(0.5g/kg/day;1ml) by oral gavage once daily for 10-day following 80% AA-induced chronic ulceration in treatment group. Pretreatment group received saline or BB for 10-day before and 3-day after ulcer induction. Stomachs of decapitated rats were collected for ulcer index, histological and biochemical analyses.Results: BB significantly reduced the gastric ulcer index and levels of chemiluminescence, HMGB-1, IL-6, IL-1ß and IL-8 levels in pretreatment and treatment groups. In BB-pretreated ulcer group, MPO-(salineBB, 39.9±3.7 U/g;22.2±2.2 U/g), caspase-3 (0.40±0.07 ng/g;0.18±0.01 ng/g) and IFN-γ (15.46±1.76;9.51±1.95 ng/g) levels decreased and TNF-α (31.77±5.13;18.94±2.59 ng/g) reduced only in BB-treated ulcer group. MDA, GSH, NRF-2, and 8-OHdG levels remained unchanged.Conclusion: BB has demonstrated protective and therapeutic effects by reducing ROS production, modulating inflammation and apoptosis.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"610-620"},"PeriodicalIF":2.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vitamin D₃ administration ameliorates the anxiety and depressive-like behaviour induced by nicotine withdrawal: a mechanistic focus on oxidative stress, inflammatory response, and serotonergic transmission. 维生素D3可改善尼古丁戒断引起的焦虑和抑郁样行为：机制聚焦于氧化应激、炎症反应和血清素能传递。

IF 2.7 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-08-01 Epub Date: 2025-04-08 DOI: 10.1080/13813455.2025.2483508

Farimah Beheshti, Mehrnoush Goudarzi, Samaneh Kakhki, S Mohammad Ahmadi-Soleimani, Mustafa Ansari, Hassan Azhdari-Zarmehri

引用次数: 0

Serum levels of omentin and visfatin in patients with metabolic syndrome. 代谢综合征患者血清大网膜蛋白和内脏脂肪素水平。

IF 2.7 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-08-01 Epub Date: 2025-04-11 DOI: 10.1080/13813455.2025.2486290

Anita Sherly A, Rukmini M S, Anupama Hegde, Arun S, Himani Kotian

{"title":"Serum levels of omentin and visfatin in patients with metabolic syndrome.","authors":"Anita Sherly A, Rukmini M S, Anupama Hegde, Arun S, Himani Kotian","doi":"10.1080/13813455.2025.2486290","DOIUrl":"10.1080/13813455.2025.2486290","url":null,"abstract":"Introduction: Metabolic Syndrome (MetS) is a global health concern characterised by cardiometabolic risk factors, dysregulated adipokine signalling and inflammation. The study aimed to assess the serum levels of omentin and visfatin in patients with metabolic syndrome.Methods: The 84-subject hospital-based case-control study included 18-55 years, both genders. Anthropometry, medical history, fasting plasma glucose (FPG), lipid profile, and HOMA-IR were collected. Insulin, omentin, and visfatin were measured using ELISA.Results: Omentin and visfatin levels significantly differed between groups (p < 0.05). The median omentin levels were 50.74 and 45.25; visfatin levels were 0.064 and 0.001, respectively. Omentin correlated with waist circumference, blood pressure, and FPG in controls, while visfatin correlated with HDL and BMI among cases (p < 0.05). Omentin and visfatin were elevated in cases. However, no significant correlation between omentin and visfatin with lipid parameters could be established.Conclusion: Omentin and visfatin levels varied significantly between metabolic syndrome and controls; their correlation with MetS criteria was not significant.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"683-690"},"PeriodicalIF":2.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of cinnamon and statins drug on kidney and liver of rats receiving gentamicin. 肉桂和他汀类药物对庆大霉素大鼠肾脏和肝脏的影响。

IF 2.7 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-08-01 Epub Date: 2025-02-20 DOI: 10.1080/13813455.2025.2465335

Abdulrahim Aljamal, Mahmoud Al Shawabkeh, Taha Alqadi

引用次数: 0

Neem seed protein hydrolysates alleviate iron-induced cardiac injury via effects on angiotensin-converting enzyme, purinergic enzymes, redox balance, and lipid metabolism. 印度楝籽蛋白水解物通过影响血管紧张素转换酶、嘌呤能酶、氧化还原平衡和脂质代谢来减轻铁诱导的心脏损伤。

IF 2.7 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-08-01 Epub Date: 2025-03-28 DOI: 10.1080/13813455.2025.2483912

Marvellous A Acho, Ochuko L Erukainure, Veronica F Salau, Osarenkhoe O Osemwegie, Eric Amonsou, Rotimi O Arise

{"title":"Neem seed protein hydrolysates alleviate iron-induced cardiac injury via effects on angiotensin-converting enzyme, purinergic enzymes, redox balance, and lipid metabolism.","authors":"Marvellous A Acho, Ochuko L Erukainure, Veronica F Salau, Osarenkhoe O Osemwegie, Eric Amonsou, Rotimi O Arise","doi":"10.1080/13813455.2025.2483912","DOIUrl":"10.1080/13813455.2025.2483912","url":null,"abstract":"This study assessed the cardioprotective effects of <1 kDa peptide fractions from neem seed protein hydrolysates (NSPHs) in cardiac tissues ex vivo. Oxidative injury was induced in cardiac tissues from male Wister rats by incubating with 0.1 mM FeSO4 (pro-oxidant) for 30 minutes. Untreated tissues lacked peptide fractions, while normal control tissues lacked peptide and pro-oxidant. Treatment with the peptides increased the activities/levels of catalase, superoxide dismutase, ENTPDase, 5'NTPDase, glutathione, and HDL-cholesterol. Conversely, the levels/activities of malondialdehyde, nitric oxide, cholesterol, LDL-cholesterol, ACE, acetylcholinesterase, ATPase decreased following treatment with NSPH peptide fractions. Furthermore, the peptides depleted oxidative metabolites, while concomitantly inactivating plasmalogen synthesis and beta-oxidation of long-chain saturated fatty acids. These findings suggest that <1 kDa peptide fractions from neem seed protein hydrolysates have cardioprotective properties, potentially offering a natural therapeutic option for managing oxidative cardiac dysfunction through the regulation of oxidative stress, cholinesterase and purinergic activities, and lipid metabolism.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"670-682"},"PeriodicalIF":2.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0