Archives of Physiology and Biochemistry最新文献_第10页

IoT based athlete physical training improves metabolic obesity symptoms: Muscle thermal energy consumption. 基于物联网的运动员体能训练改善代谢性肥胖症状：肌肉热能消耗。

IF 2.7 4区医学

Archives of Physiology and Biochemistry Pub Date : 2026-01-08 DOI: 10.1080/13813455.2025.2610477

Jiang Zhe

引用次数: 0

FAK transfection alleviates myogenic differentiation of C2C12 myoblasts under spike protein intervention: protein metabolism analysis. 转染FAK可减轻刺突蛋白干预下C2C12成肌细胞的成肌分化：蛋白质代谢分析。

IF 2.7 4区医学

Archives of Physiology and Biochemistry Pub Date : 2026-01-06 DOI: 10.1080/13813455.2025.2610478

Tianqi Zhang, Hui Peng, Tingting Lu, Jun Deng, Xin Huo, Ying Liu

{"title":"FAK transfection alleviates myogenic differentiation of C2C12 myoblasts under spike protein intervention: protein metabolism analysis.","authors":"Tianqi Zhang, Hui Peng, Tingting Lu, Jun Deng, Xin Huo, Ying Liu","doi":"10.1080/13813455.2025.2610478","DOIUrl":"https://doi.org/10.1080/13813455.2025.2610478","url":null,"abstract":"Patients with COVID-19 caused by the novel coronavirus (SARS-CoV-2) often present with long-term muscle weakness symptoms, which are closely related to metabolic disorders. Spike protein (SP) is the main structural protein of SARS-CoV-2, which can upregulate inflammatory factors and affect cell function. This study aims to explore the effect of spike protein on myogenic differentiation of C2C12 myoblasts and its mechanism of action through protein metabolism analysis. The spike protein significantly inhibits the proliferation and differentiation of C2C12 myoblasts, manifested as decreased cell density. Protein metabolism analysis revealed that after spike protein intervention, the pathways related to protein synthesis within cells were inhibited, while those related to protein degradation were activated, indicating that protein metabolism disorders might be an important mechanism of cell damage. FAK transfection can significantly improve cell damage caused by spike proteins, promote myogenic differentiation, and partially restore the normal expression of protein metabolic pathways.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-10"},"PeriodicalIF":2.7,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145910274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of PDCA cycle method in the management of anesthetic, psychotropic and toxic drugs in a grassroots traditional Chinese medicine hospital: neurological regulation. PDCA循环法在基层中医院麻醉、精神、毒性药物管理中的应用分析：神经调节。

IF 2.7 4区医学

Archives of Physiology and Biochemistry Pub Date : 2026-01-01 DOI: 10.1080/13813455.2025.2610482

Jingying Li, Xiuhong Zhu, Bizhong Zhang, Jing Zhang, Lili Xu, Min Zhou, Bin Lin

{"title":"Analysis of PDCA cycle method in the management of anesthetic, psychotropic and toxic drugs in a grassroots traditional Chinese medicine hospital: neurological regulation.","authors":"Jingying Li, Xiuhong Zhu, Bizhong Zhang, Jing Zhang, Lili Xu, Min Zhou, Bin Lin","doi":"10.1080/13813455.2025.2610482","DOIUrl":"https://doi.org/10.1080/13813455.2025.2610482","url":null,"abstract":"Background: Narcotic drugs, psychotropic drugs and toxic drugs are categories of drugs strictly controlled, and their use and management must strictly comply with relevant laws and regulations.Purpose: This study aims to explore the application effect of the PDCA cycle method in the management of anaesthetics, psychotropic and toxic drugs in primary-level traditional Chinese medicine hospitals, and to analyse its mechanism of action in optimising drug management in combination with the theoretical basis of nervous system regulation.Methods and results: After two rounds of PDCA cycle management, the management deficiencies of anaesthetics, psychotropic and toxic drugs were significantly reduced, and the rationality rate of prescriptions was significantly improved. The PDCA cycle method, combined with the theoretical basis of nervous system regulation, can effectively enhance the management level of anaesthetics.Conclusion: The application of this method in drug management has significant theoretical and practical value and is worthy of promotion and application in primary medical institutions.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-7"},"PeriodicalIF":2.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145888275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

JWX-A1223 attenuates cognitive deficits and tau protein hyperphosphorylation via the Akt/GSK3β pathway in APP/PS1 mice. JWX-A1223通过Akt/GSK3β通路减轻APP/PS1小鼠的认知缺陷和tau蛋白过度磷酸化。

IF 2.7 4区医学

Archives of Physiology and Biochemistry Pub Date : 2026-01-01 DOI: 10.1080/13813455.2025.2610481

Wenwen Yu, Dongpei Zhuang, Kewei Wang, Yaxuan Qu

{"title":"JWX-A1223 attenuates cognitive deficits and tau protein hyperphosphorylation via the Akt/GSK3β pathway in APP/PS1 mice.","authors":"Wenwen Yu, Dongpei Zhuang, Kewei Wang, Yaxuan Qu","doi":"10.1080/13813455.2025.2610481","DOIUrl":"https://doi.org/10.1080/13813455.2025.2610481","url":null,"abstract":"Backgound: Alzheimer's disease (AD) is a neurodegenerative disorder marked by cognitive decline, affecting memory, thinking, and behaviour. Its neuropathology includes amyloid plaques and neurofibrillary tangles in the brain.Materials: Amyloid plaques consist of misfolded beta-amyloid protein, while tangles are made of hyperphosphorylated tau protein.Method: After treatment with JWX-A1223, the APP/PS1 mice showed significant cognitive improvement in the Morris water maze test. They had shorter escape latency, reduced swimming distance, and longer stay time in the target quadrant, indicating enhanced spatial learning and memory.Results: The treatment with JWX-A1223 also significantly reduced the phosphorylation levels of tau protein at Ser202, Ser396 and Ser404 sites in the cerebral cortex and hippocampus of mice, while increasing the phosphorylation levels at Ser473 site of Akt and Ser9 site of GSK3β.Conslusion: It indicates that by regulating the activity of the Akt/GSK3β pathway, it alleviates the excessive phosphorylation of tau protein and thereby improves cognitive impairment.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-12"},"PeriodicalIF":2.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145888252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Repetitive transcranial magnetic stimulation combined with stepwise task orientation for upper limb function in stroke patients: neurological function test. 重复经颅磁刺激联合分步任务定向对脑卒中患者上肢功能的影响：神经功能测试。

IF 2.7 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-12-30 DOI: 10.1080/13813455.2025.2610479

Yanhong Huang, Fanjun Qin, Haozhe Qu, Bingbing Pu

{"title":"Repetitive transcranial magnetic stimulation combined with stepwise task orientation for upper limb function in stroke patients: neurological function test.","authors":"Yanhong Huang, Fanjun Qin, Haozhe Qu, Bingbing Pu","doi":"10.1080/13813455.2025.2610479","DOIUrl":"https://doi.org/10.1080/13813455.2025.2610479","url":null,"abstract":"Stroke rehabilitation traditionally focuses on restoring motor function through physical exercises and training. However, conventional methods often lack a strong theoretical basis from modern neuroscience. Integrating these technologies into rehabilitation protocols shifts the focus from peripheral movement to a brain-centred model, using objective biomarkers for assessment. The study involved 87 chronic stroke patients divided into three groups: Group A received rTMS and task-oriented training, Group B received sham rTMS and task-oriented training, and Group C received conventional rehabilitation and sham rTMS. The intervention lasted four weeks. Comprehensive assessments, were used to evaluate neurobiological and functional changes. Results showed that Group A exhibited significantly greater improvements in motor function, daily living activities, and muscle tone compared to the control groups. Neuroimaging revealed increased connectivity within the affected motor network and normalised interhemispheric balance in Group A. These findings support the effectiveness of the combined rTMS and task-oriented training approach.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-20"},"PeriodicalIF":2.7,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145861963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Minimally invasive lung resection combined with CT guided percutaneous microwave ablation for the treatment of lung cancer: diagnosis of postoperative nerve damage. 微创肺切除术联合CT引导下经皮微波消融治疗肺癌：术后神经损伤的诊断。

IF 2.7 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-12-29 DOI: 10.1080/13813455.2025.2610480

Hang Zhao, Junlei Wu, Weiwei Hu, Yueming Wu

{"title":"Minimally invasive lung resection combined with CT guided percutaneous microwave ablation for the treatment of lung cancer: diagnosis of postoperative nerve damage.","authors":"Hang Zhao, Junlei Wu, Weiwei Hu, Yueming Wu","doi":"10.1080/13813455.2025.2610480","DOIUrl":"https://doi.org/10.1080/13813455.2025.2610480","url":null,"abstract":"Background: Minimally invasive lung resection combined with CT-guided percutaneous microwave ablation for multiple radiographic non-invasive lung cancer (mGGN-LC) is applicable to patients with multiple pulmonary nodules.Materials and methods: The study adopted a prospective cohort design and included 40-60 patients with multiple radiographic non-invasive lung cancer who had surgical indications. The research focuses on analysing the incidence rate, manifestations and the effectiveness of diagnostic methods of postoperative nerve damage.Results: Studies have shown that minimally invasive lung resection combined with CT-guided percutaneous microwave ablation for multiple radiographic non-invasive lung cancers is a safe and effective treatment strategy. The combination of thermal medical imaging diagnostic techniques can significantly reduce the incidence of postoperative neurological complications.Conclusion: The diagnosis and management of postoperative nerve damage are of great significance in multimodal treatment. Through full-process imaging support and clinical assessment, the postoperative quality of life of patients can be effectively improved.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-15"},"PeriodicalIF":2.7,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145848742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective effects of intermittent fasting and chamomile extract against margarine-induced oxidative stress in mouse tissues. 间歇性禁食和洋甘菊提取物对人造黄油诱导的小鼠组织氧化应激的保护作用。

IF 2.7 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-12-29 DOI: 10.1080/13813455.2025.2610470

Viktoriia V Hurza, Myroslava V Vatashchuk, Maria M Bayliak, Volodymyr I Lushchak

{"title":"Protective effects of intermittent fasting and chamomile extract against margarine-induced oxidative stress in mouse tissues.","authors":"Viktoriia V Hurza, Myroslava V Vatashchuk, Maria M Bayliak, Volodymyr I Lushchak","doi":"10.1080/13813455.2025.2610470","DOIUrl":"https://doi.org/10.1080/13813455.2025.2610470","url":null,"abstract":"Oxidative stress induced by diets rich in trans-unsaturated fatty acids is well-documented. However, their organ-specific effects and the potential of antioxidant interventions remain unclear. This study investigated the effects of margarine intake, with or without chamomile water decoction (CWD) or intermittent fasting (IF), on oxidative status in young C57BL/6J mice over 16 weeks. Margarine-fed mice had elevated lipid peroxide (LOOH) levels in the kidneys (females) and cortex (both sexes), while levels were lower in muscle and unchanged in the heart of both sexes. Activities of glutathione-dependent enzymes were higher in both sexes of margarine-fed mice. The addition of CWD to margarine provided antioxidant protection in female kidneys and heart, but caused oxidative damage in male heart. The margarine with IF demonstrated tissue-specific antioxidant benefits. Thus, margarine induces oxidative stress in a sex- and tissue-specific way. CWD and IF can counteract these effects, offering potential protective strategies against margarine-induced oxidative stress.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-14"},"PeriodicalIF":2.7,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145848749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medical domain knowledge-enhanced automatic decision support for traumatic brain injury: protein nutrition intervention for traumatic brain injury. 外伤性脑损伤的医学领域知识增强自动决策支持：蛋白质营养干预外伤性脑损伤。

IF 2.7 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-12-22 DOI: 10.1080/13813455.2025.2600337

Rui Xu, Yulong Xia, Lidan Zhang, Weijun Xu, Jiaying Wen, Li Jiang

{"title":"Medical domain knowledge-enhanced automatic decision support for traumatic brain injury: protein nutrition intervention for traumatic brain injury.","authors":"Rui Xu, Yulong Xia, Lidan Zhang, Weijun Xu, Jiaying Wen, Li Jiang","doi":"10.1080/13813455.2025.2600337","DOIUrl":"https://doi.org/10.1080/13813455.2025.2600337","url":null,"abstract":"Background: Traumatic brain injury (TBI) is a common neurosurgical emergency with a high rate of disability and mortality. In the treatment of TBI, apart from timely and effective clinical intervention measures, reasonable nutritional support also plays a significant role, among which protein nutrition intervention has attracted particular attention.Purpose: This study aims to develop a clinical decision support system (CDSS), namely the T system, to automatically analyse the medical text data of TBI patients and output treatment plans, which also takes into account the importance of protein nutrition intervention.Method: Therefore, the T system developed in this study can automatically identify and analyse the medical text data of TBI patients, and quickly output accurate treatment plans including protein nutrition intervention.Conclusion: This system is expected to provide important decision support for clinicians, optimise the treatment process for TBI patients, improve treatment efficiency and enhance patient prognosis.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-13"},"PeriodicalIF":2.7,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145803166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipid peroxidation-induced neurocardiac dysfunction in critically ill patients with septic shock. 脓毒性休克危重患者脂质过氧化诱导的神经心脏功能障碍。

IF 2.7 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-12-19 DOI: 10.1080/13813455.2025.2592032

Duowen Xie, Xiaoyuan Shi

{"title":"Lipid peroxidation-induced neurocardiac dysfunction in critically ill patients with septic shock.","authors":"Duowen Xie, Xiaoyuan Shi","doi":"10.1080/13813455.2025.2592032","DOIUrl":"https://doi.org/10.1080/13813455.2025.2592032","url":null,"abstract":"Context: Septic shock's fatal signs include hemodynamic collapse, systemic inflammation, and organ failure. Neurocardiac dysfunctions worsen outcomes, with lipid peroxidation from oxidative stress as a key damage mechanism.Objective: Aim of this study is to investigates how lipid peroxidation in cell membranes generates excessive reactive oxygen species (ROS), leading to mitochondrial damage, cell death, and autonomic dysfunction.Materials and methods: Malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), toxic byproducts, contribute to cardiomyocyte injury, endothelial damage, blood-brain barrier disruption, and altered neuronal signalling. The research analyzes preclinical and clinical data associating sepsis oxidative indicators with poorer cardiac and neurological outcomes. Results: chronological relationship between oxidative stress, cardiac damage, and neural injury. While the visualisation highlights elevated biomarker levels in critically ill neurocardiac patients.Discussion and conclusion: Early diagnosis, risk classification, and focused treatment for septic shock may benefit from understanding neurocardiac dysfunction and lipid peroxidation.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-21"},"PeriodicalIF":2.7,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145793280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between ubiquinol-cytochrome c reductase complex assembly factor 2 expression and skin cutaneous melanoma pathogenesis and prognosis: neurological and protein metabolism intervention. 泛醇-细胞色素c还原酶复合物组装因子2表达与皮肤黑色素瘤发病和预后的关系：神经学和蛋白质代谢干预。

IF 2.7 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-12-17 DOI: 10.1080/13813455.2025.2600338

Xiaofang Sun, Jianping Zhang, Shaohan Wu, Chuanbo Liu

{"title":"Association between ubiquinol-cytochrome c reductase complex assembly factor 2 expression and skin cutaneous melanoma pathogenesis and prognosis: neurological and protein metabolism intervention.","authors":"Xiaofang Sun, Jianping Zhang, Shaohan Wu, Chuanbo Liu","doi":"10.1080/13813455.2025.2600338","DOIUrl":"https://doi.org/10.1080/13813455.2025.2600338","url":null,"abstract":"Background: Cutaneous melanoma (SKCM) is a highly malignant and poorly prognostic skin tumour, and its incidence rate is on the rise worldwide. At present, the treatment options for SKCM are limited, and the overall prognosis of patients is poor.Purpose: It is urgent to find effective biomarkers and therapeutic targets.Method: Based on clinical sample data, the relationship between UQCC2 expression and patient prognosis was analysed, and its possible molecular mechanism was explored.Results: Functional enrichment analysis revealed that among the genes co-expressed with UQCC2, many were related to neural and protein metabolism, suggesting that neural and protein metabolism interventions might affect the malignant phenotype of SKCM After knocking down UQCC2 in SKCM cells, the proliferation, migration and invasion abilities of the cells were significantly reduced.Conclusion: It also implies that neural and protein metabolic interventions may affect the biological behaviour of SKCM cells by regulating the expression and function of UQCC2.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-14"},"PeriodicalIF":2.7,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145766871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0