Archives of Physiology and Biochemistry最新文献_第10页

The promising roles of medicinal plants and bioactive compounds on hepatic lipid metabolism in the treatment of non-alcoholic fatty liver disease in animal models: molecular targets. 药用植物和生物活性化合物在治疗非酒精性脂肪肝动物模型中对肝脏脂质代谢的重要作用:分子靶点

IF 3 4区医学

Archives of Physiology and Biochemistry Pub Date : 2023-12-01 Epub Date: 2021-06-21 DOI: 10.1080/13813455.2021.1939387

Zaida Zakaria, Zaidatul Akmal Othman, Victor Udo Nna, Mahaneem Mohamed

{"title":"The promising roles of medicinal plants and bioactive compounds on hepatic lipid metabolism in the treatment of non-alcoholic fatty liver disease in animal models: molecular targets.","authors":"Zaida Zakaria, Zaidatul Akmal Othman, Victor Udo Nna, Mahaneem Mohamed","doi":"10.1080/13813455.2021.1939387","DOIUrl":"10.1080/13813455.2021.1939387","url":null,"abstract":"Imbalance in hepatic lipid metabolism can lead to an abnormal triglycerides deposition in the hepatocytes which can cause non-alcoholic fatty liver disease (NAFLD). Four main mechanisms responsible for regulating hepatic lipid metabolism are fatty acid uptake, de novo lipogenesis, lipolysis and fatty acid oxidation. Controlling the expression of transcription factors at molecular level plays a crucial role in NAFLD management. This paper reviews various medicinal plants and their bioactive compounds emphasising mechanisms involved in hepatic lipid metabolism, other important NAFLD pathological features, and their promising roles in managing NAFLD through regulating key transcription factors. Although there are many medicinal plants popularly investigated for NAFLD treatment, there is still little information and scientific evidence available and there has been no research on clinical trials scrutinised on this matter. This review also aims to provide molecular information of medicinal plants in NALFD treatment that might have potentials for future scientifically controlled studies.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1262-1278"},"PeriodicalIF":3.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13813455.2021.1939387","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39253937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Securidaca inappendiculata stem extract confers robust antioxidant and antidiabetic effects against high fructose/streptozotocin induced type 2 diabetes in rats. Exploration of bioactive compounds using UHPLC-ESI-QTOF-MS. 蛇尾藤茎提取物对高果糖/链脲佐菌素诱导的2型糖尿病大鼠具有强大的抗氧化和降糖作用。UHPLC-ESI-QTOF-MS技术对生物活性化合物的研究。

IF 3 4区医学

Archives of Physiology and Biochemistry Pub Date : 2023-12-01 Epub Date: 2021-05-13 DOI: 10.1080/13813455.2021.1921811

Opeyemi Joshua Olatunji, Jian Zuo, Oladipupo Odunayo Olatunde

{"title":"Securidaca inappendiculata stem extract confers robust antioxidant and antidiabetic effects against high fructose/streptozotocin induced type 2 diabetes in rats. Exploration of bioactive compounds using UHPLC-ESI-QTOF-MS.","authors":"Opeyemi Joshua Olatunji, Jian Zuo, Oladipupo Odunayo Olatunde","doi":"10.1080/13813455.2021.1921811","DOIUrl":"10.1080/13813455.2021.1921811","url":null,"abstract":"Diabetes mellitus is the most deadly and most prevalent metabolic disease of contemporary times. This study evaluated the antidiabetic, antioxidant, and pancreato-protective effects of Securidaca inappendiculata extract (SIE) in high-fructose/streptozotocin-induced type 2 diabetes. SIE (50, 100, and 200 mg/kg) was administered to diabetic rats for 8 weeks, thereafter glycaemic parameters, pancreatic β cell function, lipid profile, hepatorenal function, and antioxidant parameters were evaluated in diabetic rats treated SIE. The results indicated that treatment with SIE markedly lowered blood glucose, lipid parameters, hepatorenal function parameters, and lipid peroxidation at the end of the intervention. Additionally, serum insulin levels were significantly increased as supported by restoration of pancreatic β-cell cells in the H&E staining. Moreover, SIE also upregulated serum antioxidant enzyme activities in the treated diabetic rats. The results revealed that SIE possesses potent antihyperglycemic and antihyperlipidemic and antioxidant effects with the considerable restoration of pancreatic β-cells function.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1187-1199"},"PeriodicalIF":3.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13813455.2021.1921811","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38977918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

miR-765 targeting PDX1 impairs pancreatic β-cell function to induce type 2 diabetes. 靶向PDX1的miR-765损害胰腺β细胞功能诱导2型糖尿病。

IF 3 4区医学

Archives of Physiology and Biochemistry Pub Date : 2023-12-01 Epub Date: 2021-08-06 DOI: 10.1080/13813455.2021.1946561

Li Zheng, Yalan Wang, Yanhong Li, Li Li, Xiaohong Wang, Yan Li

{"title":"miR-765 targeting PDX1 impairs pancreatic β-cell function to induce type 2 diabetes.","authors":"Li Zheng, Yalan Wang, Yanhong Li, Li Li, Xiaohong Wang, Yan Li","doi":"10.1080/13813455.2021.1946561","DOIUrl":"10.1080/13813455.2021.1946561","url":null,"abstract":"Type 2 diabetes (T2DM) is a chronic metabolism disorder with a symptom as pancreatic β-cell dysfunction. In this study, the bioinformatics analysis identified the key regulators (PDX1 and miR-765) in T2DM. By qRT-PCR and western blotting, miR-765 with high expression and PDX1 with low expression were observed in blood samples from T2DM patients and the T2DM cell model. Together with GSIS assay, CCK-8, TUNEL assay, glycolysis assay, and mitochondrial respiration assay, miR-765 overexpression impaired insulin secretion cell viability, glycolysis, and mitochondrial respiration, while enhanced cell apoptosis in pancreatic β-cell. The Luciferase reporter, RIP, and RNA pull-down assays showed that PDX1 was the target gene of miR-765 in pancreatic β-cell. Besides, the negative effect of miR-765 on pancreatic β-cell could be overturned by PDX1 overexpression. In conclusion, we confirmed that miR-765 could cause a detrimental effect on pancreatic β-cell survival and function by targeting PDX1, which might provide new insight for T2DM therapy.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1279-1288"},"PeriodicalIF":3.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13813455.2021.1946561","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39283368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Bisphenol A induces non-alcoholic fatty liver disease by promoting the O-GlcNAcylation of NLRP3. 双酚A通过促进NLRP3的o - glcn酰化诱导非酒精性脂肪肝。

IF 3 4区医学

Archives of Physiology and Biochemistry Pub Date : 2023-12-01 DOI: 10.1080/13813455.2023.2288533

Yonghong Zhang, Shujuan Han, Tian Li, Li Zhu, Feng Wei

{"title":"Bisphenol A induces non-alcoholic fatty liver disease by promoting the O-GlcNAcylation of NLRP3.","authors":"Yonghong Zhang, Shujuan Han, Tian Li, Li Zhu, Feng Wei","doi":"10.1080/13813455.2023.2288533","DOIUrl":"10.1080/13813455.2023.2288533","url":null,"abstract":"Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease. The mechanism by which bisphenol A (BPA) promots NAFLD remains unclear. Palmitic acid (PA) and lipopolysaccharide (LPS) were used to simulate NAFLD in HepG2 cells in vitro. Total cholesterol (TC), triglyceride (TG) content, and lipid accumulation were measured to evaluate lipid metabolism. The caspase-1-stained cells and NLRP3 inflammasome-associated proteins were evaluated for pyroptosis. Western blot analysis was used to detect protein levels and co-immunoprecipitation (Co-IP) was used to detect the association between the proteins. Cycloheximide (CHX) treatment combined with western blot was performed to access protein stability. This data have shown that BPA induces lipid metabolism dysfunction and pyroptosis by upregulating O-GlcNAc transferase (OGT) level. NLRP3 directly interacts with OGT, and elevated OGT enhanced the stability of NLRP3 protein. BPA promoted OGT-mediated O-GlcNAcylation to stabilised NLRP3, thus accelerating NAFLD progress in vitro. Our study reveals that BPA, as an environmental factor, may be involved in the promotion of NAFLD, and that targeting NLRP3 and OGT may inhibit BPA's induction of NAFLD.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-9"},"PeriodicalIF":3.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138457563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does symbiotic supplementation which contains Bacillus Coagulans Lactobacillus rhamnosus, Lactobacillus acidophilus and fructooligosaccharide has favourite effects in patients with type-2 diabetes? A randomised, double-blind, placebo-controlled trial. 含有凝固芽孢杆菌、鼠李糖乳杆菌、嗜酸乳杆菌和低聚果糖的共生补充剂对2型糖尿病患者有良好的效果吗?一项随机、双盲、安慰剂对照试验。

IF 3 4区医学

Archives of Physiology and Biochemistry Pub Date : 2023-12-01 Epub Date: 2021-06-02 DOI: 10.1080/13813455.2021.1928225

Aynaz Velayati, Iman Kareem, Meghdad Sedaghat, Golbon Sohrab, Omid Nikpayam, Mehdi Hedayati, Khadijeh Abhari, Ehsan Hejazi

{"title":"Does symbiotic supplementation which contains Bacillus Coagulans Lactobacillus rhamnosus, Lactobacillus acidophilus and fructooligosaccharide has favourite effects in patients with type-2 diabetes? A randomised, double-blind, placebo-controlled trial.","authors":"Aynaz Velayati, Iman Kareem, Meghdad Sedaghat, Golbon Sohrab, Omid Nikpayam, Mehdi Hedayati, Khadijeh Abhari, Ehsan Hejazi","doi":"10.1080/13813455.2021.1928225","DOIUrl":"10.1080/13813455.2021.1928225","url":null,"abstract":"This study aimed to determine the effect of Bacillus Coagulans symbiotic supplementation on metabolic factors and inflammation in patients with type-2 diabetes. In this clinical trial, 50 patients with type-2 diabetes were randomly assigned to the symbiotic (containing Bacillus Coagulans + Lactobacillus rhamnosus + Lactobacillus acidophilus and fructooligosaccharide) or placebo groups to receive one sachet daily for 12 weeks. Glycaemic Index, lipid profile, and hs-CRP were measured at the beginning and end of the study. Analysis of covariance demonstrated that fasting blood glucose (FBG), insulin, homeostatic Model Assessment for Insulin Resistance (HOMA-IR), β-cell function (HOMA-β) (p <.05) and hs-CRP (p <.05) significantly declined in the treatment group compared with the placebo group. So, the current study indicated that Bacillus Coagulans symbiotic supplementation could improve metabolic factors and inflammation in patients with type-2 diabetes.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1211-1218"},"PeriodicalIF":3.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13813455.2021.1928225","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38985234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Multiple novel functions of circular RNAs in diabetes mellitus. 环状rna在糖尿病中的多种新功能。

IF 3 4区医学

Archives of Physiology and Biochemistry Pub Date : 2023-12-01 Epub Date: 2021-06-04 DOI: 10.1080/13813455.2021.1933047

Sadra Samavarchi Tehrani, Golnaz Goodarzi, Ghodratollah Panahi, Mahmood Maniati, Reza Meshkani

引用次数: 6

Metformin mediates MicroRNA-21 regulated circulating matrix metalloproteinase-9 in diabetic nephropathy: an in-silico and clinical study. 二甲双胍介导MicroRNA-21调节的糖尿病肾病循环基质金属蛋白酶-9:一项计算机和临床研究。

IF 3 4区医学

Archives of Physiology and Biochemistry Pub Date : 2023-12-01 Epub Date: 2021-06-04 DOI: 10.1080/13813455.2021.1922457

Manoj Khokhar, Dipayan Roy, Nitin Kumar Bajpai, Gopal Krishna Bohra, Dharamveer Yadav, Praveen Sharma, Purvi Purohit

{"title":"Metformin mediates MicroRNA-21 regulated circulating matrix metalloproteinase-9 in diabetic nephropathy: an in-silico and clinical study.","authors":"Manoj Khokhar, Dipayan Roy, Nitin Kumar Bajpai, Gopal Krishna Bohra, Dharamveer Yadav, Praveen Sharma, Purvi Purohit","doi":"10.1080/13813455.2021.1922457","DOIUrl":"10.1080/13813455.2021.1922457","url":null,"abstract":"Metformin is commonly used as an oral hypoglycaemic agent in type 2 diabetes mellitus (T2DM). MicroRNA-21 is widely studied in diabetic and diabetic nephropathy (DN) patients. Matrix metalloproteinase-9 (MMP9) is involved in extracellular matrix degradation and tissue repair processes. However, the effect of metformin administration on hsa-miR-21-5p and MMP9 has not been evaluated in T2DM and DN patients. The study subjects were divided into three groups (Healthy controls = 36, T2DM = 38, DN = 35). Anthropometric measurements were taken and biochemical tests were carried out on fasting blood samples. Reverse transcriptase PCR was employed for whole blood gene expression analysis of hsa-miR-21-5p and MMP9. Bioinformatics analyses including drug-gene interaction, protein-protein interaction, functional enrichment analyses and co-expression networks were performed. In the present study, MMP9 and hsa-miR-21-5p levels were downregulated and upregulated respectively in T2DM and DN patients when compared with healthy controls. However, in metformin-treated group, a downregulation of hsa-miR-21-5p and upregulation of MMP9 was observed. In-silico analysis revealed the target genes involved in the miR-21 and MMP9 interaction network. Metformin directly targets miR-21 and regulates MMP9 expression in T2DM patients, influencing the pathogenesis of DN.HighlightsMMP-9 and hsa-miR-21-5p were downregulated and upregulated respectively in T2DM and DN patients in a Western Indian population.The patients treated with metformin showed downregulation of hsa-miR-21-5p and upregulation of MMP9.In-silico analysis revealed MMP-9 as well as PTEN to be targets of hsa-miR-21-5p.Metformin regulates MMP9 expression in T2DM and DN patient populations through hsa-miR-21-5p.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1200-1210"},"PeriodicalIF":3.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13813455.2021.1922457","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39077842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Actoeside mitigated the renal proximal tubule cells damage triggered by high glucose through miR-766/VCAM1/NF-κB signalling pathway. actoside通过miR-766/VCAM1/NF-κB信号通路减轻高糖引发的肾近端小管细胞损伤。

IF 3 4区医学

Archives of Physiology and Biochemistry Pub Date : 2023-12-01 Epub Date: 2021-08-02 DOI: 10.1080/13813455.2021.1920983

Xiaodong Zhao, Honglei Hu, Kun Sun, Wenlong Liang, Zhenzhen Wang, Xingqian Jin, Shujuan Wang

{"title":"Actoeside mitigated the renal proximal tubule cells damage triggered by high glucose through miR-766/VCAM1/NF-κB signalling pathway.","authors":"Xiaodong Zhao, Honglei Hu, Kun Sun, Wenlong Liang, Zhenzhen Wang, Xingqian Jin, Shujuan Wang","doi":"10.1080/13813455.2021.1920983","DOIUrl":"10.1080/13813455.2021.1920983","url":null,"abstract":"Context: Diabetic nephropathy (DN) triggered by diabetes mellitus is one of the primary causes of end-stage renal failure worldwide.Objective: This study intends to explore the function and potential mechanism of actoeside on renal proximal tubule (HK-2) cells damage induced by high-glucose (HG).Methods: The DN model was established in HK-2 cells with 30 mM HG treatment. The viability, apoptosis and inflammation of HK-2 cells were analysed severally via CCK-8, flow cytomery and ELISA. The key factors related to NF-κB were detected by western blotting.Results: Actoeside attenuated the HG-induced HK-2 cells damage. The differentially expression of miR-766 and VCAM1 in DN patients was reversed by actoeside. Moreover, the increased phosphorylation levels of p65 NF-κB/IκBα induced by HG were attenuated by actoeside.Conclusions: Actoeside promoted the growth and repressed the apoptosis and inflammation of HK-2 cells via miR-766/VCAM1/NF-κB signalling pathway, affording a promising idea for the treatment of DN.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1177-1186"},"PeriodicalIF":3.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13813455.2021.1920983","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39267834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of the different hormonal status changes during their life on fat mass localisation in women: a narrative review. 女性一生中不同激素状态变化对脂肪块定位的影响:一项叙述性回顾。

IF 3 4区医学

Archives of Physiology and Biochemistry Pub Date : 2023-12-01 Epub Date: 2021-06-10 DOI: 10.1080/13813455.2021.1933045

Laurie Isacco, Gaël Ennequin, Nathalie Boisseau

{"title":"Influence of the different hormonal status changes during their life on fat mass localisation in women: a narrative review.","authors":"Laurie Isacco, Gaël Ennequin, Nathalie Boisseau","doi":"10.1080/13813455.2021.1933045","DOIUrl":"10.1080/13813455.2021.1933045","url":null,"abstract":"Context: Independently of the total body fat mass, upper body fat mass deposition is strongly associated with cardiometabolic comorbidities. The mechanisms underlying fat mass localisation are not fully understood, but evidences indicate sex-specific fat mass distribution. Currently, data on women are scarce and the link between hormonal status changes during their life and fat mass distribution is overlooked.Method: For this narrative review, literature data were extracted from the PubMed and CENTRAL databases to examine the relationship between hormonal status and adipose tissue localisation in women.Results: Menopause strongly influences fat mass localisation, while the effect of the menstrual cycle phases, oral contraception use and pregnancy has not been unambiguously determined.Conclusion: Reliable data are lacking on the relationship between hormonal variations throughout the lifespan and body fat mass localisation in women. Future studies should take into account the hormonal status of women to reduce the risk of cardiometabolic diseases.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1229-1234"},"PeriodicalIF":3.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13813455.2021.1933045","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39013166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Determination of mitochondrial functions and damage in kidney in female LeeSung minipigs with a high-fat diet-induced obesity. 高脂饮食性肥胖雌性LeeSung迷你猪线粒体功能和肾脏损伤的测定。

IF 3 4区医学

Archives of Physiology and Biochemistry Pub Date : 2023-12-01 Epub Date: 2021-08-02 DOI: 10.1080/13813455.2021.1949022

Miao-Ju Chien, Sin-Jin Li, Shiu-Chung Wong, Chun-Hsien Chiang, Yuan-Yu Lin, Harry J Mersmann, Ching-Yi Chen

{"title":"Determination of mitochondrial functions and damage in kidney in female LeeSung minipigs with a high-fat diet-induced obesity.","authors":"Miao-Ju Chien, Sin-Jin Li, Shiu-Chung Wong, Chun-Hsien Chiang, Yuan-Yu Lin, Harry J Mersmann, Ching-Yi Chen","doi":"10.1080/13813455.2021.1949022","DOIUrl":"10.1080/13813455.2021.1949022","url":null,"abstract":"The purpose of this study was to investigate the nexus between mitochondrial function and kidney injury by using a dietary-induced obese minipig model. Female Lee-Sung minipigs feeding a high-fat diet (HFD) for 6 months exhibited obesity, hyperglycaemia and dyslipidemia. HFD elevated the levels of plasma biomarkers related to renal injury, including symmetric dimethylarginine, creatinine and urea nitrogen. An extensive structural change in tubules and glomeruli was observed in HFD-fed pigs. A great amount of triacylglycerol was accumulated in HFD kidney compared to control kidney, whereas a reduction of ATP level and antioxidant capacity were exhibited in HFD kidney. Moreover, HFD altered the expressions of mitochondrial-related protein in renal cortex. To conclude, long-term HFD feeding to Lee-Sung minipigs induced obesity and kidney injury accompanied by abnormal mitochondrial functions in the renal cortex, suggesting an interrelationship with renal disease progression.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1289-1297"},"PeriodicalIF":3.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/13813455.2021.1949022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39275357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2