Archives of Physiology and Biochemistry最新文献

Unveiling the mechanism of Coenzyme Q10 in ameliorating ageing related oxidative and inflammatory lung alterations in rats via targeting PI3K/AKT/Nrf-2 signaling pathway. 揭示辅酶Q10通过靶向PI3K/AKT/Nrf-2信号通路改善大鼠衰老相关的氧化和炎症性肺改变的机制。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-07-01 DOI: 10.1080/13813455.2025.2525415

Elshymaa A Abdel-Hakeem, Nisreen D M Toni, Doaa Mohamed Elroby Ali, Heba Marey, Heba A Abdel-Hamid

{"title":"Unveiling the mechanism of Coenzyme Q10 in ameliorating ageing related oxidative and inflammatory lung alterations in rats via targeting PI3K/AKT/Nrf-2 signaling pathway.","authors":"Elshymaa A Abdel-Hakeem, Nisreen D M Toni, Doaa Mohamed Elroby Ali, Heba Marey, Heba A Abdel-Hamid","doi":"10.1080/13813455.2025.2525415","DOIUrl":"https://doi.org/10.1080/13813455.2025.2525415","url":null,"abstract":"Objectives: Lung is one of the vital organs that is affected by the ageing process. Searching for natural antioxidants is mandatory to boost healthier longevity. Accordingly, we sought to explore the probable protective effect of Coenzyme Q10 (Q10) on experimentally induced lung ageing and study the supposed involved mechanistic pathways.Methods: Rats were allocated into groups; control, D-galactose (D-gal), D-gal + Q10 and D-gal + Q10+ LY294002 (LY; phosphatidylinositol 3-kinases (PI3K)/protein kinase B (AKT) inhibitor). Sera and lung tissues were gathered for evaluating markers of oxidative stress, inflammation, fibrosis, and cell senescence by different methods.Immunohistochemistry for senescence associated beta galactosidase (SA-βGal), Capsase-3, and P53 were also evaluated.Results: Induction of lung ageing resulted in deleterious lung alterations which were ameliorated by Q10; however, its protective effect was abolished by co-administration of LY.Conclusion: Q10 secured the lung against the ageing process via its antioxidant, anti-inflammatory, and anti-apoptotic effects through the activation of the PI3K/AKT/Nrf-2 pathway.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-17"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An efficient attention Densenet with LSTM for lung disease detection and classification using X-ray images supported by adaptive R2-Unet-based image segmentation. 基于自适应r2 - unet图像分割的基于LSTM的高效关注密度网络用于肺部疾病检测和分类。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-07-01 DOI: 10.1080/13813455.2025.2524182

Sashi Kanth Betha, Dondapati Rajendra Dev, Kalyani Sunkara, Pradeep Vinaik Kodavanti, Anusha Putta

{"title":"An efficient attention Densenet with LSTM for lung disease detection and classification using X-ray images supported by adaptive R2-Unet-based image segmentation.","authors":"Sashi Kanth Betha, Dondapati Rajendra Dev, Kalyani Sunkara, Pradeep Vinaik Kodavanti, Anusha Putta","doi":"10.1080/13813455.2025.2524182","DOIUrl":"https://doi.org/10.1080/13813455.2025.2524182","url":null,"abstract":"Lung diseases represent one of the most prevalent health challenges globally, necessitating accurate diagnosis to improve patient outcomes. This work presents a novel deep learning-aided lung disease classification framework comprising three key phases: image acquisition, segmentation, and classification. Initially, chest X-ray images are taken from standard datasets. The lung regions are segmented using an Adaptive Recurrent Residual U-Net (AR2-UNet), whose parameters are optimised using Enhanced Pufferfish Optimisation Algorithm (EPOA) to enhance segmentation accuracy. The segmented images are processed using \"Attention-based Densenet with Long Short Term Memory(ADNet-LSTM)\" for robust categorisation. Investigational results demonstrate that the proposed model achieves the highest classification accuracy of 93.92%, significantly outperforming several baseline models including ResNet with 90.77%, Inception with 89.55%, DenseNet with 89.66%, and \"Long Short Term Memory (LSTM)\" with 91.79%. Thus, the proposed framework offers a dependable and efficient solution for lung disease detection, supporting clinicians in early and accurate diagnosis.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-31"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insulin- and glucagon-producing cells in the liver and biliary-pancreatic axis of rats with experimentally induced metabolic syndrome. 实验性代谢综合征大鼠肝脏和胆胰轴中胰岛素和胰高血糖素生成细胞的研究。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-06-28 DOI: 10.1080/13813455.2025.2503482

M Gulubova, A Tolekova, D Berbatov, I Stefanov, D Chonov, N Aydoglu

{"title":"Insulin- and glucagon-producing cells in the liver and biliary-pancreatic axis of rats with experimentally induced metabolic syndrome.","authors":"M Gulubova, A Tolekova, D Berbatov, I Stefanov, D Chonov, N Aydoglu","doi":"10.1080/13813455.2025.2503482","DOIUrl":"https://doi.org/10.1080/13813455.2025.2503482","url":null,"abstract":"Context: The generation of insulin-producing cells (IPCs) as cell replacement therapy for diabetes treatment is challenging.Objective: We have evaluated the presence of insulin-positive (insulin+) and glucagon-positive (glucagon+) cells in hepatocytes, peribiliary glands (PBGs), and liver sinusoidal endothelial cells (LSECs).Materials and methods: Wistar rats are subjected to a diet including administration of 15% fructose solution for 3 months. Tissue samples are processed for immunohistochemistry with antibodies against insulin, glucagon, ghrelin, somatostatin, PDX1, and SOX9. Blood glucose levels and lipid profile are investigated.Results: In treated rats, Ins+ and glucagon+ hepatocytes are found around central veins. In PBGs, Ins+ and glucagon+ endocrine cells (ECs) are detected. LSECs show insulin+ and glucagon+ cellular membranes. The nuclei of LSECs in treated rats are SOX9-positive.Conclusions: Our experiment of fructose-induced metabolic syndrome shows the appearance of Ins+ and glucagon+ ECs in extrahepatic biliary pathways and hepatocytes. Interestingly, SOX9+ nuclei of LSECs are observed.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-9"},"PeriodicalIF":2.5,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dysregulation of the glycoprotein zymogen granules in pancreatic acinar cells in acute pancreatitis: differential protection by vitamin E and metformin. 急性胰腺炎胰腺腺泡细胞中糖蛋白酶原颗粒的失调：维生素E和二甲双胍的不同保护作用。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-06-16 DOI: 10.1080/13813455.2025.2518366

Fahad S Al Amri, Norah M Alzamil, Bahjat Al-Ani, Hind Zafrah, Nervana M Bayoumy, Mohamed Abd Ellatif, Samaa S Kamar, Saeed M Alqahtani, Abeer I Omar, Asmaa M ShamsEldeen

{"title":"Dysregulation of the glycoprotein zymogen granules in pancreatic acinar cells in acute pancreatitis: differential protection by vitamin E and metformin.","authors":"Fahad S Al Amri, Norah M Alzamil, Bahjat Al-Ani, Hind Zafrah, Nervana M Bayoumy, Mohamed Abd Ellatif, Samaa S Kamar, Saeed M Alqahtani, Abeer I Omar, Asmaa M ShamsEldeen","doi":"10.1080/13813455.2025.2518366","DOIUrl":"https://doi.org/10.1080/13813455.2025.2518366","url":null,"abstract":"We investigated whether induction of acute pancreatitis (AP) can cause dysregulation in the glycoprotein zymogens, following episodes of nitrosative stress, which may be differentially protected by vitamin E and metformin. AP was induced in rats by L-arginine (2.5 g/kg) injections (two doses given at 1-h interval). The protective groups were pre-treated with either vitamin E (60 mg/kg) or metformin (50 mg/kg) prior to L-arginine injections and continued on these medications until being sacrificed. AP markedly decreased the density of zymogen granules in pancreatic acinar cells (44.5 ± 2.2% in control versus 9.2 ± 1.9% in AP), alongside tissue damage and a significant (p < 0.0001) increase in biomarkers of nitrosative stress (iNOS), inflammation (IL-6 and TNF-α mRNA), and pancreatic injury (amylase, lipase, LDH, and MPO). All these parameters were significantly (p ≤ 0.0005) protected by vitamin E and metformin, with vitamin E providing greater protection for pancreatic glycoprotein zymogens and serum amylase. Thus, AP is associated with the destruction of the glycoprotein zymogens, which is differentially protected by vitamin E and metformin.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-10"},"PeriodicalIF":2.5,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DenSFFNet: dense spiking forward fractional network for cardiovascular risk prediction using retinal fundus images in spark framework. DenSFFNet：基于spark框架下视网膜眼底图像的心血管风险预测的密集尖峰前向分数网络。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-06-09 DOI: 10.1080/13813455.2025.2503478

Kanchanamala P, Anuradha G, Radhika Gouni

{"title":"DenSFFNet: dense spiking forward fractional network for cardiovascular risk prediction using retinal fundus images in spark framework.","authors":"Kanchanamala P, Anuradha G, Radhika Gouni","doi":"10.1080/13813455.2025.2503478","DOIUrl":"https://doi.org/10.1080/13813455.2025.2503478","url":null,"abstract":"Cardiovascular risk prediction identifies individuals at high risk before symptoms arise. To address challenges such as integrating diverse data, ensuring quality, and managing patient variability, the Dense Spiking Forward Fractional Network (DenSFFNet) model is introduced within the Spark framework. The process begins with image acquisition and partitioning using Deep Embedded Clustering (DEC), followed by preprocessing tasks like Greyscale Conversion, Optic Disc (OD) segmentation with Channel Prior Convolutional Attention (CPCA), and blood vessel segmentation using Frangi-Net across slave nodes. Extracted features, including Learned Invariant Feature Transformation (LIFT) and statistical metrics, are aggregated by the master node, which utilises the DenSFFNet model a combination of DenseNet and Deep Spiking Neural Network (DSNN). The DenSFFNet method attained accuracy, sensitivity, specificity, and Matthews correlation coefficient (MCC) is 91.119%, 90.366%, 89.922%, and 92.643% for dataset 1. For the RFMiD 2.0 dataset, the proposed method attained 90.881% accuracy, 90.286% sensitivity, 89.660% specificity, and 91.469% MCC.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-22"},"PeriodicalIF":2.5,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Living high-training low model promotes increased spontaneous physical activity, reduced adiposity and maintenance of fat-free mass in C57BL/6J mice. 生活高训练低模型促进C57BL/6J小鼠自发性体力活动增加、脂肪减少和无脂质量维持。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-06-06 DOI: 10.1080/13813455.2025.2507757

Juan B Orsi, Pedro P M Scariot, Emanuel E C Polisel, Lara S Araujo, Matheus R Santos, Marcelo Papoti, Fúlvia B Manchado-Gobatto, Claudio A Gobatto

{"title":"Living high-training low model promotes increased spontaneous physical activity, reduced adiposity and maintenance of fat-free mass in C57BL/6J mice.","authors":"Juan B Orsi, Pedro P M Scariot, Emanuel E C Polisel, Lara S Araujo, Matheus R Santos, Marcelo Papoti, Fúlvia B Manchado-Gobatto, Claudio A Gobatto","doi":"10.1080/13813455.2025.2507757","DOIUrl":"https://doi.org/10.1080/13813455.2025.2507757","url":null,"abstract":"Researchers have extensively studied how hypoxia affects physiological variables, with training models like \"live high - train low\" (LH-TL) proposed by Levine & Stray-Gundersen in 1997 to improve athletic performance. Although well-known, few studies use animal models for more in-depth analyses than human studies allow. This study investigated the effects of aerobic training on adiposity, spontaneous physical activity (SPA), and food and water intake in C57BL/6J mice housed in normoxic (Nx) or hypoxic (Hx) conditions for 8 weeks. Mice were divided into trained (T) and sedentary (S) groups, with 10 mice each. Hx animals were kept in normobaric hypoxia (FiO2=14.5%) for 18 h/day. Training was done at 80% critical velocity, 5 times/week in normoxia. The T groups had lower SPA, especially the Hx-T group, which showed higher food and water intake, reduced fat, and a higher fat-free mass/carcass fat mass ratio. Findings suggest exercise and hypoxia may help combat obesity.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-14"},"PeriodicalIF":2.5,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The protective effects of Salusin-α against oxidative stress and inflammatory response in mice with gestational diabetes mellitus (GDM). Salusin-α对妊娠期糖尿病小鼠氧化应激和炎症反应的保护作用。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-06-01 Epub Date: 2025-02-21 DOI: 10.1080/13813455.2025.2456876

Yujie Zhang, Yi Ye, Xiaorui Jia, Pu Wang, Zheng Xiong, Hui Zhu

引用次数: 0

Correction. 更正。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-06-01 Epub Date: 2024-11-23 DOI: 10.1080/13813455.2024.2432763

引用次数: 0

Possible consequences of the abuse of anabolic steroids on different organs of athletes. 滥用合成代谢类固醇对运动员不同器官可能造成的后果。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-06-01 Epub Date: 2025-02-03 DOI: 10.1080/13813455.2025.2459283

Hamed Alizadeh Pahlavani, Ali Veisi

{"title":"Possible consequences of the abuse of anabolic steroids on different organs of athletes.","authors":"Hamed Alizadeh Pahlavani, Ali Veisi","doi":"10.1080/13813455.2025.2459283","DOIUrl":"10.1080/13813455.2025.2459283","url":null,"abstract":"Objective: Androgenic steroids abuse among young athletes has long-term health consequences, causing profound damage to vital organs such as the heart, blood vessels, brain, liver, gonads, kidneys, and skin.Results: In the vessels, steroids cause plaque formation, vascular calcification, thrombosis, and coronary artery disease, and in the heart, they lead to pathological fibrosis, dilated cardiomyopathy, heart failure, fatal ventricular arrhythmias, acute myocardial infarction, and reduced ejection fraction. The brain also suffers from cognitive decline, memory impairment, and a constellation of neurotransmitter abnormalities that lead to depression. In the liver, the consequences are severe and manifest as increased oxidative stress, liver dysfunction, hepatotoxicity, cholestatic jaundice, liver tumours, cell death, and elevations in liver enzymes, bilirubin, and cholesterol. Male athletes experience testicular atrophy, temporary suppression of spermatogenesis, hypogonadism, reduced fertility, infertility, and hormonal imbalance. In contrast, women experience ovarian dysfunction and menstrual irregularities. In the kidney, steroids lead to increased inflammatory cytokines, fibrosis, renal tubular hypertrophy, glomerular changes, and structural damage, and show higher levels of serum creatinine, urinary protein, and cystatin C. In athletes, steroids can lead to various skin problems such as acne, gynecomastia, prostatitis, and alopecia.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"393-409"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neem seed oil ameliorates diabetic phenotype by suppressing redox imbalance, dyslipidaemia and pro-inflammatory mediators in a rodent model of type 2 diabetes. 楝树籽油通过抑制 2 型糖尿病啮齿动物模型中的氧化还原失衡、血脂异常和促炎介质，改善糖尿病表型。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-06-01 Epub Date: 2024-11-16 DOI: 10.1080/13813455.2024.2426497

Bartholomew I C Brai, Ruth Ometere Joseph, Titilope Ruth Komolafe, Busayo Elizabeth Amosun, Olamide Olajusi Crown, Kayode Komolafe, Ifedayo Victor Ogungbe

{"title":"Neem seed oil ameliorates diabetic phenotype by suppressing redox imbalance, dyslipidaemia and pro-inflammatory mediators in a rodent model of type 2 diabetes.","authors":"Bartholomew I C Brai, Ruth Ometere Joseph, Titilope Ruth Komolafe, Busayo Elizabeth Amosun, Olamide Olajusi Crown, Kayode Komolafe, Ifedayo Victor Ogungbe","doi":"10.1080/13813455.2024.2426497","DOIUrl":"10.1080/13813455.2024.2426497","url":null,"abstract":"The neem plant (Azadirachta indica) has popular ethnomedicinal applications. The anti-diabetic potential and mechanism of neem seed oil (NSO) in a rodent model of type 2 diabetes mellitus was evaluated in the present study. Experimentally-induced diabetic animals were administered NSO (200 and 400 mg/kg) or metformin (150 mg/kg) orally for 30 days, with some animals serving as positive and negative controls. NSO significantly (p < .05) reversed diabetes-induced impaired glucose metabolism, dyslipidaemia, and oxido-inflammatory imbalances typified by changes in the NADH/NAD+ ratio (p < .001) and increases in the mRNA or protein levels of C-reactive protein, 4-hydroxynonenal, and pro-inflammatory cytokines (TNF-α and Il-1β) among others in the hepatic or pancreatic tissues of diabetic animals. The histological evaluation of the pancreatic tissue corroborated the protective effect of NSO. The findings showed that the antidiabetic effect of NSO proceeded through its hypolipidemic effect and modulation of redox and inflammatory signalling events in the tissues of animals.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"351-365"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142643304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0