Archives of Physiology and Biochemistry最新文献

Combination therapy of systemic and local metformin improves imiquimod-induced psoriasis-like lesions with type 2 diabetes: the role of AMPK/KGF/STAT3 axis. 全身和局部二甲双胍联合疗法可改善咪喹莫特诱导的 2 型糖尿病银屑病样皮损：AMPK/KGF/STAT3 轴的作用。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-04-01 Epub Date: 2024-10-24 DOI: 10.1080/13813455.2024.2407547

Fatma ElSayed Hassan, Basma Emad Aboulhoda, Marwa Nagi Mehesen, Passant Mohie El Din, Hend Ahmed Abdallah, Ehab R Bendas, Laila Ahmed Rashed, Abeer Mostafa, Marwa Fathy Amer, Marwa Abdel-Rahman, Mansour A Alghamdi, Asmaa Mohammed Shams Eldeen

{"title":"Combination therapy of systemic and local metformin improves imiquimod-induced psoriasis-like lesions with type 2 diabetes: the role of AMPK/KGF/STAT3 axis.","authors":"Fatma ElSayed Hassan, Basma Emad Aboulhoda, Marwa Nagi Mehesen, Passant Mohie El Din, Hend Ahmed Abdallah, Ehab R Bendas, Laila Ahmed Rashed, Abeer Mostafa, Marwa Fathy Amer, Marwa Abdel-Rahman, Mansour A Alghamdi, Asmaa Mohammed Shams Eldeen","doi":"10.1080/13813455.2024.2407547","DOIUrl":"10.1080/13813455.2024.2407547","url":null,"abstract":"Context: Insulin resistance and a disturbed lipid profile are common associations with type 2 diabetes mellitus (T2DM) and different skin diseases, particularly psoriasis (PsO).Objectives: We investigated potential therapeutic mechanisms of metformin in a murine animal model of psoriasiform lesions in T2DM.Materials and methods: Forty-two rats were randomly divided into control, PsO, and type II DM (T2DM) groups. After confirmation of DM, the type II diabetic rats were allocated into T2DM+ PsO, T2DM+ PsO+ systemic metformin (S. met), T2DM+ PsO+ topical metformin (T. met)), and T2DM+ PsO + combined metformin (C. met). PsO was induced by topical imiquimod.Results: Systemic administration of the cornerstone antidiabetic drug, metformin, was able to improve insulin resistance and lipid profile. At molecular levels, both topical and systemic metformin significantly increased AMP-activated protein kinase (AMPK), and lowered keratinocyte growth factor (KGF) / \"Signal transducer and activator of transcription\" (STAT)3 protein levels, and the IL-17RA and IL-17RC gene expression.Conclusion: Although its glucose-controlling effect was not optimum, T.met gel served anti-psoriatic and anti-inflammatory effects.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"252-264"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142493689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of Helicobacter pylori-derived extracellular vesicles on glucose metabolism and induction of insulin resistance in HepG2 cells. 幽门螺杆菌衍生的细胞外囊泡对 HepG2 细胞葡萄糖代谢和诱导胰岛素抵抗的影响

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-04-01 Epub Date: 2024-10-21 DOI: 10.1080/13813455.2024.2418494

Ghazaleh Talebi, Parvaneh Saffarian, Mojdeh Hakemi-Vala, Amir Sadeghi, Abbas Yadegar

{"title":"The effect of Helicobacter pylori-derived extracellular vesicles on glucose metabolism and induction of insulin resistance in HepG2 cells.","authors":"Ghazaleh Talebi, Parvaneh Saffarian, Mojdeh Hakemi-Vala, Amir Sadeghi, Abbas Yadegar","doi":"10.1080/13813455.2024.2418494","DOIUrl":"10.1080/13813455.2024.2418494","url":null,"abstract":"Helicobacter pylori infection has been associated with the development of insulin resistance (IR). This study aimed to examine the effect of H. pylori-derived extracellular vesicles (EVs) on IR induction. EVs were derived from two H. pylori strains, and characterised by transmission electron microscopy and dynamic light scattering. Different concentrations of insulin were added to HepG2 cells to induce IR model. HepG2 cells were exposed to various concentrations of H. pylori-derived EVs to assess IR development. The gene expression of IRS1, AKT2, GLUT2, IL-6, SOCS3, c-Jun and miR-140 was examined using RT-qPCR. Glucose uptake analysis revealed insulin at 5 × 10 -7 mol/l and EVs at 50 µg/ml induced IR model in HepG2 cells. H. pylori-derived EVs downregulated the expression level of IRS1, AKT2, and GLUT2, and upregulated IL-6, SOCS3, c-Jun, and miR-140 expression in HepG2 cells. In conclusion, our findings propose a novel mechanism by which H. pylori-derived EVs could potentially induce IR.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"316-327"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142456829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of exogenous ghrelin treatment on oxidative stress, inflammation and histological parameters in a fat-fed streptozotocin rat model. 外源性胃泌素对脂肪喂养链脲佐菌素大鼠模型氧化应激、炎症和组织学参数的影响

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-04-01 Epub Date: 2024-09-26 DOI: 10.1080/13813455.2024.2407551

Ozlem Ergul Erkec, Zubeyir Huyut, Eda Acikgoz, Mehmet Tahir Huyut

{"title":"Effects of exogenous ghrelin treatment on oxidative stress, inflammation and histological parameters in a fat-fed streptozotocin rat model.","authors":"Ozlem Ergul Erkec, Zubeyir Huyut, Eda Acikgoz, Mehmet Tahir Huyut","doi":"10.1080/13813455.2024.2407551","DOIUrl":"10.1080/13813455.2024.2407551","url":null,"abstract":"In this study, the anti-inflammatory, antioxidative, and protective effects of ghrelin were investigated in a fat-fed streptozotocin (STZ) rat model and compared with metformin, diabetes and the healthy control groups. Histopathological evaluations were performed on H&E-stained pancreas and brain sections. Biochemical parameters were investigated by enzyme-linked immunosorbent assay. Blood glucose levels were significantly decreased with ghrelin or metformin treatments than the diabetes group. STZ administration increased brain, renal and pancreatic IL-1β, TNF-α and MDA while decreasing GPX, CAT, SOD, and NGF levels. Ghrelin increased renal GPX, CAT, NGF pancreatic GPX, SOD, CAT, NGF and brain SOD, NGF while it decreased renal, pancreatic and brain IL-1β, TNF-α and MDA levels. Ghrelin reduced neuronal loss and degeneration in the cerebral cortex and hippocampus and greatly ameliorated diabetes-related damage in pancreas. In conclusion, the data suggested that ghrelin is an effective candidate as a protectant for reducing the adverse effects of diabetes.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"274-284"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142340141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 更正。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-04-01 Epub Date: 2024-10-22 DOI: 10.1080/13813455.2024.2418702

引用次数: 0

Artichoke leaf hydroethanolic extract reduces neuropathic pain in a rat model of chronic constriction injury via attenuating the sciatic nerve oxidative stress. 朝鲜蓟叶水乙醇提取物可通过减轻坐骨神经氧化应激减轻慢性收缩损伤模型大鼠的神经痛。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-04-01 Epub Date: 2024-09-25 DOI: 10.1080/13813455.2024.2406898

Mohammad Mehdi Haghighat Lari, Mohammad Reza Bakhoda, Mohammad Shabani, Mohsen Taghizadeh, Fereshteh Bahmani, Gholamali Hamidi, Fatemeh Aghighi, Sayyed Alireza Talaei

{"title":"Artichoke leaf hydroethanolic extract reduces neuropathic pain in a rat model of chronic constriction injury via attenuating the sciatic nerve oxidative stress.","authors":"Mohammad Mehdi Haghighat Lari, Mohammad Reza Bakhoda, Mohammad Shabani, Mohsen Taghizadeh, Fereshteh Bahmani, Gholamali Hamidi, Fatemeh Aghighi, Sayyed Alireza Talaei","doi":"10.1080/13813455.2024.2406898","DOIUrl":"10.1080/13813455.2024.2406898","url":null,"abstract":"Neuropathic pain, a nerve damage consequence, presents symptoms such as dysesthesia, hyperalgesia, and allodynia. This study aimed to evaluate the alleviating potential of artichoke leaf extract in neuropathic pain induced by chronic constriction injury (CCI) of the sciatic nerve in male rats. The hydroethanolic extract of artichoke leaf was administered via gavage at doses of 200, 400, and 800 mg/kg for 21 days. Behavioural tests were conducted on days 1, 4, 7, 14, and 21 post-surgeries. Only the dose of 800 mg/kg significantly reduced thermal hyperalgesia and allodynia from day 14 and mechanical allodynia from day 7, and the other doses did not affect behaviours. Biochemical analysis showed that artichoke extract decreased lipid peroxidation and restored antioxidant enzyme activities (SOD and GPx) in the sciatic nerve tissue. In conclusion, artichoke leaf extract administration diminishes neuropathic pain-related behaviours by enhancing antioxidant capacity and reducing oxidative stress in the rats' sciatic nerve.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"227-233"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142340139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Huaiqihuang (HQH) protects podocytes from high glucose-induced apoptosis and inflammation response by regulating PI3K/AKT/mTOR pathway. 怀其黄（HQH）通过调节 PI3K/AKT/mTOR 通路，保护荚膜细胞免受高糖诱导的细胞凋亡和炎症反应的影响。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-04-01 Epub Date: 2024-09-27 DOI: 10.1080/13813455.2024.2407552

Peipei Zhang, Zhilong Liu, Guiqiao Ma, Junwei Wang, Jing Shao, Chaojing Ma, Liping Wang, Chanjuan Ma

引用次数: 0

Chronic whole-body heat treatment in obese insulin-resistant C57BL/6J mice. 对肥胖的胰岛素抵抗型 C57BL/6J 小鼠进行慢性全身热处理。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-04-01 Epub Date: 2024-09-26 DOI: 10.1080/13813455.2024.2406904

Helena Trevisan Schroeder, Carlos Henrique de Lemos Muller, Maria Inês Lavina Rodrigues, Marcela Alves de Azevedo, Victor de Souza Borges, Cristiana Maria Sponchiado, Paulo Ivo Homem de Bittencourt

{"title":"Chronic whole-body heat treatment in obese insulin-resistant C57BL/6J mice.","authors":"Helena Trevisan Schroeder, Carlos Henrique de Lemos Muller, Maria Inês Lavina Rodrigues, Marcela Alves de Azevedo, Victor de Souza Borges, Cristiana Maria Sponchiado, Paulo Ivo Homem de Bittencourt","doi":"10.1080/13813455.2024.2406904","DOIUrl":"10.1080/13813455.2024.2406904","url":null,"abstract":"Aim: This study examined the effects of hyperthermic therapy (HT) on mice fed normal chow or a high-fat diet (HFD) for 18 or 22 weeks, undergoing four or eight weekly HT sessions.Methods: Mice were housed within their thermoneutral zone (TNZ) to simulate a physiological response. HFD-induced obesity-related changes, including weight gain, visceral fat accumulation, muscle loss (indicative of obesity sarcopenia), glucose intolerance, and hepatic triglyceride buildup.Main results: HT upregulated HSP70 expression in muscles, mitigated weight gain, normalised QUICK index, and reduced plasma HSP70 concentrations. It also lowered the H-index of HSP70 balance, indicating improved immunoinflammatory status, and decreased activated caspase-1 and proliferative senescence in adipose tissue, both linked to insulin resistance.Conclusion: The findings suggest that even animals on a \"control\" diet but with insufficient physical activity and within their TNZ may experience impaired glycaemic homeostasis.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"234-251"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142340140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The protective effects of Myrtus communis subsp. on ovariectomized diabetic rats' renal and intestinal tissues: in vivo and in silico approaches. 桃金娘亚种对卵巢切除糖尿病大鼠肾脏和肠道组织的保护作用：体内和硅学方法。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-04-01 Epub Date: 2024-09-26 DOI: 10.1080/13813455.2024.2406895

Onur Ertik, Beril Kadıoğlu-Yaman, Ali Şen, Göksel Şener, Refiye Yanardag

{"title":"The protective effects of Myrtus communis subsp. on ovariectomized diabetic rats' renal and intestinal tissues: in vivo and in silico approaches.","authors":"Onur Ertik, Beril Kadıoğlu-Yaman, Ali Şen, Göksel Şener, Refiye Yanardag","doi":"10.1080/13813455.2024.2406895","DOIUrl":"10.1080/13813455.2024.2406895","url":null,"abstract":"Introduction: Postmenopausal diabetes is a condition that affects millions of women and their quality of life. Also, kidney and small intestine tissues are damaged due to diabetes. The present study aimed to examine the protective effects of an extract prepared from Myrtus communis leaves on kidney and small intestine tissues against experimentally created postmenopausal diabetes.Methods: For this purpose, experimental rats were randomly divided into six groups (Control; ovariectomy:OVX, diabetic:D, ovariectomy + diabetic:OVX + D, ovariectomy + diabetic + oestrogen:OVX + D+E2, ovariectomy + diabetic + MC: OVX + D+MC) and kidney and small intestine tissues were taken after the experimental procedure.Results: Evaluations of biochemical parameters (glutathione and glutathione-related enzymes, antioxidant enzymes, etc.) showed that MC had a protective effect on kidney and small intestine tissues in diabetes and ovariectomy groups.Conclusion: It can be suggested that MC extract has a protective effect on small intestine and kidney tissues in postmenopausal diabetes and may be a good herbal source for this purpose.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"210-226"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142340144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Growth, fusion and degradation of lipid droplets: advances in lipid droplet regulatory protein. 脂滴的生长、融合和降解：脂滴调节蛋白的研究进展。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-04-01 Epub Date: 2024-08-08 DOI: 10.1080/13813455.2024.2388779

Yusong Ge, Yu Cao, Feng Li, Jiaxin Wang, Yuhao Liu, Wenjin Guo, Juxiong Liu, Shoupeng Fu

{"title":"Growth, fusion and degradation of lipid droplets: advances in lipid droplet regulatory protein.","authors":"Yusong Ge, Yu Cao, Feng Li, Jiaxin Wang, Yuhao Liu, Wenjin Guo, Juxiong Liu, Shoupeng Fu","doi":"10.1080/13813455.2024.2388779","DOIUrl":"10.1080/13813455.2024.2388779","url":null,"abstract":"Context: An adequate supply of energy is essential for the proper functioning of all life activities in living organisms. As organelles that store neutral lipids, lipid droplets (LDs) are involved in the synthesis and metabolism of lipids in cells and are also an important source of energy supply.Methods and mechanisms: A comprehensive summary of the literature was first carried out to screen for relevant proteins affecting the morphological size of LDs. The size of milk fat globules (MFGs) is directly influenced by the morphological size of LDs, which also controls the energy storage capacity of LDs. In this review, we detail the progress of research into the role of some protein in regulating the morphological size of LDs.Conclusion: It has been discovered that the number of protein are involved in the control of LD growth and degradation, such as Rab18-mediated local synthesis of triacylglycerol (TAG), cell death-inducing DFF45-like effector family proteins (CIDEs)-mediated atypical fusion between LDs, Stomatin protein-mediated LD fusion and autophagy-related proteins (ATGs)-mediated autophagic degradation of LDs. However, more studies are needed in the future to enrich the network of mechanisms that regulate the morphological size of LDs.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"109-118"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141900809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polygala fallax Hemsl. ameliorated high glucose-induced podocyte injury by modulating mitochondrial mPTP opening through the SIRT1/PGC-1α pathway. 远志通过 SIRT1/PGC-1α 途径调节线粒体 mPTP 开放，从而改善高血糖诱导的荚膜细胞损伤。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-04-01 Epub Date: 2024-09-02 DOI: 10.1080/13813455.2024.2392298

Chao Shih-Wei, Bo Chen, Yanqing Mao, Qin Xu, Yige Chen

{"title":"Polygala fallax Hemsl. ameliorated high glucose-induced podocyte injury by modulating mitochondrial mPTP opening through the SIRT1/PGC-1α pathway.","authors":"Chao Shih-Wei, Bo Chen, Yanqing Mao, Qin Xu, Yige Chen","doi":"10.1080/13813455.2024.2392298","DOIUrl":"10.1080/13813455.2024.2392298","url":null,"abstract":"This study aimed to investigate the effects and molecular mechanism of PF on high glucose (HG)-induced podocyte injury. Results found that PF increased proliferation activity, decreased apoptosis, LDH, and caspase-3 levels, and increased nephrin and podocin expression in HG-induced cells. Similarly, PF improved HG-induced mitochondrial damage, decreased Ca2+ and ROS content, alleviated oxidative stress, inhibited mPTP opening, increased mitochondrial membrane potential, and decreased the expressions of Drp1, Bak, Bax, and Cytc in cytoplasm, increased the expressions of SIRT1, PGC-1α, HSP70, HK2, and Cytc in mitochondria of podocytes. The use of mPTP agonist/blocker and SIRT1 inhibitor confirmed that PF alleviates HG-induced podocyte injury by regulating mitochondrial mPTP opening through SIRT1/PGC-1α. In addition, PF affected HK2-VDAC1 protein binding to regulate mPTP opening via the SIRT1/PGC-1α pathway. In conclusion, PF-regulated HK2-VDAC1 protein binding affected mitochondrial mPTP opening and improved HG-induced podocyte injury through the SIRT1/PGC-1α pathway.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"135-146"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142103859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0