Evaluation of Annona muricata for hepatoprotection, hematological assessment and inhibitor of TGFβR1 in liver diseases.

IF 2.5 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Archives of Physiology and Biochemistry Pub Date : 2025-05-13 DOI:10.1080/13813455.2025.2499840

Zacchaeus S Ololade, Iyadunni A Anuoluwa, Olayinka F Onifade, Adewumi I Adeagbo, Olawumi T Oyebanji, Ademola O Asaju, John C Eze

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引用次数: 0

Abstract

Background: This study was conducted to assess the hepatoprotective potential of Annona muricata flower (AMF) using albino rats' model.

Materials and methods: Liver function assays such as alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBILI), antioxidants, haematology (HGB), histology, inhibition of transforming growth factor beta receptor I (TGFβR1) and antibacterial assays were investigated.

Results and discussion: Induction with acetaminophen gave rise to a significant increase (p < 0.05) in serum of liver enzymes of ALT, AST, ALP and TBILI in the acetaminophen (APAP) only group, which indicates hepatocellular injury, whereas AMF attenuated liver enzymes level. The histological assessment confirmed that AMF possesses blood-enhancing ability. AMF significantly showed inhibition of TGFβR1. AMF was active against all the tested bacteria with high zones of inhibition.

Conclusion: This study provides information on the uses of AMF as a natural product for hepatoprotection and other therapeutic purposes.

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番荔枝保肝、血液学评价及tgf - β r1抑制剂在肝脏疾病中的作用。

背景：本研究采用白化大鼠模型，探讨了番麻花（Annona muricata flower， AMF）的保肝作用。材料与方法：进行肝功能测定，如碱性磷酸酶（ALP）、丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）、总胆红素（TBILI）、抗氧化剂、血液学（HGB）、组织学、转化生长因子β受体I （tgf - β r1）抑制及抗菌试验。结果与讨论：对乙酰氨基酚（APAP）诱导组大鼠血清ALT、AST、ALP和TBILI肝酶水平显著升高（p < 0.05），提示肝细胞损伤，而AMF则使肝酶水平降低。组织学检查证实AMF具有补血作用。AMF显著抑制tgf - β r1。AMF对所有被试细菌均有活性，且具有高抑制区。结论：本研究提供了AMF作为一种天然产物用于肝保护和其他治疗目的的信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Physiology and Biochemistry ENDOCRINOLOGY & METABOLISM-PHYSIOLOGY

CiteScore

6.90

自引率

3.30%

发文量

期刊介绍： Archives of Physiology and Biochemistry: The Journal of Metabolic Diseases is an international peer-reviewed journal which has been relaunched to meet the increasing demand for integrated publication on molecular, biochemical and cellular aspects of metabolic diseases, as well as clinical and therapeutic strategies for their treatment. It publishes full-length original articles, rapid papers, reviews and mini-reviews on selected topics. It is the overall goal of the journal to disseminate novel approaches to an improved understanding of major metabolic disorders. The scope encompasses all topics related to the molecular and cellular pathophysiology of metabolic diseases like obesity, type 2 diabetes and the metabolic syndrome, and their associated complications. Clinical studies are considered as an integral part of the Journal and should be related to one of the following topics: -Dysregulation of hormone receptors and signal transduction -Contribution of gene variants and gene regulatory processes -Impairment of intermediary metabolism at the cellular level -Secretion and metabolism of peptides and other factors that mediate cellular crosstalk -Therapeutic strategies for managing metabolic diseases Special issues dedicated to topics in the field will be published regularly.