Archives of Physiology and Biochemistry最新文献_第2页

Comparable hepatocellular metabolomic signatures under glucose and palmitic acid treatment relative to butyrate in relation to metabolic dysfunction-associated fatty liver disease. 葡萄糖和棕榈酸治疗下相对于丁酸治疗与代谢功能障碍相关的脂肪肝疾病的肝细胞代谢组学特征比较

IF 2.7 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-10-01 Epub Date: 2025-05-15 DOI: 10.1080/13813455.2025.2500651

Priyankar Dey

{"title":"Comparable hepatocellular metabolomic signatures under glucose and palmitic acid treatment relative to butyrate in relation to metabolic dysfunction-associated fatty liver disease.","authors":"Priyankar Dey","doi":"10.1080/13813455.2025.2500651","DOIUrl":"10.1080/13813455.2025.2500651","url":null,"abstract":"Introduction: Among the dietary factors, glucose, and fatty acids are known to trigger fatty liver disease, while butyrate attenuates steatosis.Objective: To decipher the hepatocellular altered metabolome under nutrient perturbation relevant to fatty liver disease.Methods: HepG2 cells were cultured under the influence of sub-lethal doses of glucose, palmitic acid (PA), and butyrate. Following the treatment, intracellular metabolites were extracted and derivatized for GCMS analysis. Chemical class enrichment, metabolic pathway analysis, and metabolomic interactome analysis were undertaken.Results: Glucose, PA and butyrate caused loss of cell viability at 160 mM, 1600 µM, and 40 mM concentration, respectively. A total of 39, 47, 52, and 51 metabolites were identified in control, glucose, PA, and butyrate, respectively, among which 2-ethylhexanoic acid in control and 2-ethylhexan-1-ol in glucose, PA and butyrate were the most abundant metabolites. Pathways related to the mitochondrial electron transport chain were highly enriched in glucose and PA treatments, leading to increased free radicals. The metabolites identified under glucose and PA treatment were linked to the metabolomic markers of metabolic liver diseases.Conclusion: Our data showed that the hepatocellular metabolome of HepG2 cells under glucose and PA treatment is closely related, while the metabolome and pathways associated with butyrate treatment are associated with energy metabolism and alleviation of fatty liver.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"781-791"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DenSFFNet: dense spiking forward fractional network for cardiovascular risk prediction using retinal fundus images in spark framework. DenSFFNet：基于spark框架下视网膜眼底图像的心血管风险预测的密集尖峰前向分数网络。

IF 2.7 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-10-01 Epub Date: 2025-06-09 DOI: 10.1080/13813455.2025.2503478

Kanchanamala P, Anuradha G, Radhika Gouni

{"title":"DenSFFNet: dense spiking forward fractional network for cardiovascular risk prediction using retinal fundus images in spark framework.","authors":"Kanchanamala P, Anuradha G, Radhika Gouni","doi":"10.1080/13813455.2025.2503478","DOIUrl":"10.1080/13813455.2025.2503478","url":null,"abstract":"Cardiovascular risk prediction identifies individuals at high risk before symptoms arise. To address challenges such as integrating diverse data, ensuring quality, and managing patient variability, the Dense Spiking Forward Fractional Network (DenSFFNet) model is introduced within the Spark framework. The process begins with image acquisition and partitioning using Deep Embedded Clustering (DEC), followed by preprocessing tasks like Greyscale Conversion, Optic Disc (OD) segmentation with Channel Prior Convolutional Attention (CPCA), and blood vessel segmentation using Frangi-Net across slave nodes. Extracted features, including Learned Invariant Feature Transformation (LIFT) and statistical metrics, are aggregated by the master node, which utilises the DenSFFNet model a combination of DenseNet and Deep Spiking Neural Network (DSNN). The DenSFFNet method attained accuracy, sensitivity, specificity, and Matthews correlation coefficient (MCC) is 91.119%, 90.366%, 89.922%, and 92.643% for dataset 1. For the RFMiD 2.0 dataset, the proposed method attained 90.881% accuracy, 90.286% sensitivity, 89.660% specificity, and 91.469% MCC.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"818-839"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum levels of miR-34, miR-182 and miR-378 as novel diagnostic biomarkers in Behçet patients and their relation to disease activity and severity. miR-34、miR-182和miR-378作为behet患者新型诊断生物标志物的血清水平及其与疾病活动性和严重程度的关系

IF 2.7 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-10-01 Epub Date: 2025-04-25 DOI: 10.1080/13813455.2025.2497266

Miran M Harhash, Amr A Zahra, Omayma O Abdelaleem, Nermeen A Fouad, Hassan S El Sayed

{"title":"Serum levels of miR-34, miR-182 and miR-378 as novel diagnostic biomarkers in Behçet patients and their relation to disease activity and severity.","authors":"Miran M Harhash, Amr A Zahra, Omayma O Abdelaleem, Nermeen A Fouad, Hassan S El Sayed","doi":"10.1080/13813455.2025.2497266","DOIUrl":"10.1080/13813455.2025.2497266","url":null,"abstract":"Background: Behçet Disease (BD) is a chronic multi-systemic vasculitis of relapsing and remitting nature. Many recent studies have denoted the role of micro RNAs (MiRNAs) in the pathogenesis of BD.Subjects and methods: Blood samples were withdrawn from 50 BD patients and 40 age and sex-matched healthy individuals in this study.Results: Serum expression levels of miR-34a and miR-182 were significantly elevated in BD patients when compared to controls, p < .001. However, serum expression levels of miR-378 were significantly decreased in BD patients compared to controls, p < .001. miR-182 serum levels were also found to be elevated in active BD patients compared to patients in inactive state (p = .022). We found a significant association between miR-34 levels and joint affection in BD patients as well as a significant relation between miR-182 levels and each of neurological manifestations and genital ulcerations. In addition, a statistically significant positive correlations were proved in the current results between miR-182 expression and BDCAF score (r = 0.419, p = .002) as well as severity score (r = 0.358, p = .011).Conclusion: Our study denoted that the three miRNAs; miR-34a, miR-182, and miR-378 possibly play a crucial role in the pathogenesis of BD. The distinction of their serum levels between patients and healthy individuals suggested their potentiality as promising biomarkers for BD.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"753-762"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preconceptional treatment with açaí juçara (Euterpe edulis Martius) in advanced-age female rats did not interfere with metabolic parameters and redox balance during pregnancy. 对高龄雌性大鼠进行açaí juara （Euterpe edulis Martius）孕前处理不会干扰妊娠期间的代谢参数和氧化还原平衡。

IF 2.7 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-10-01 Epub Date: 2025-05-08 DOI: 10.1080/13813455.2025.2497260

Mayra Dias Rodrigues, Brenda Francisconi Diaz, Fernando Henrique Borges, Rhauany Pelisson Guergolette, Larissa Rugila Dos Santos Stopa, Ernane Torres Uchoa, Glaura Scantamburlo Alves Fernandes, Karla Bigetti Guergoletto, Graziela Scalianti Ceravolo

{"title":"Preconceptional treatment with açaí juçara (Euterpe edulis Martius) in advanced-age female rats did not interfere with metabolic parameters and redox balance during pregnancy.","authors":"Mayra Dias Rodrigues, Brenda Francisconi Diaz, Fernando Henrique Borges, Rhauany Pelisson Guergolette, Larissa Rugila Dos Santos Stopa, Ernane Torres Uchoa, Glaura Scantamburlo Alves Fernandes, Karla Bigetti Guergoletto, Graziela Scalianti Ceravolo","doi":"10.1080/13813455.2025.2497260","DOIUrl":"10.1080/13813455.2025.2497260","url":null,"abstract":"The consumption of açaí has been shown to be beneficial to health. This study aimed to evaluate the effects of juçara açai (JU, Euterpe edulis Martius) administration before gestation on the biometric, metabolic, and oxidative status in pregnant rats of advanced maternal age. Healthy female Wistar rats were treated with JU pulp via gavage from postnatal day 168 to 210. After treatment, the rats were mated, and during the 20 days of pregnancy, they were evaluated for body weight (BW), glucose tolerance, adipose tissue and liver weight, the lipid profile, and hepatic oxidative status. At birth, the offspring were weighed and counted. It was observed that JU reduced just maternal glycaemia. The maternal preconceptional treatment did not affect offspring BW. These results suggest that JU could be a safe nutritional intervention during the preconception period in advanced maternal age.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"744-752"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heptaminol-induced metabolic liver and cardiac injuries in rats: phytochemical screening, experimental, computational modelling and pharmacological study of phoenix dactylifera seeds. 七胺醇致大鼠代谢性肝、心损伤：凤草种子的植物化学筛选、实验、计算模型及药理研究。

IF 2.7 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-10-01 Epub Date: 2025-05-15 DOI: 10.1080/13813455.2025.2504169

Raoudha Abbassi, Hafsia Bouzenna, Riadh Badraoui, Mohammad Atwan, Faten Brahmi, Anouer Feriani, Arif J Siddiqui, Mohd Adnan, Ahmed Mohajja, Sirine Choura, Mohamed Chamkha, Najla Hfaiedh

{"title":"Heptaminol-induced metabolic liver and cardiac injuries in rats: phytochemical screening, experimental, computational modelling and pharmacological study of phoenix dactylifera seeds.","authors":"Raoudha Abbassi, Hafsia Bouzenna, Riadh Badraoui, Mohammad Atwan, Faten Brahmi, Anouer Feriani, Arif J Siddiqui, Mohd Adnan, Ahmed Mohajja, Sirine Choura, Mohamed Chamkha, Najla Hfaiedh","doi":"10.1080/13813455.2025.2504169","DOIUrl":"10.1080/13813455.2025.2504169","url":null,"abstract":"Introduction: Heptaminol (HEP) is widely used and characterized by liver and cardiac risk factors, dysregulated prooxidant-antioxidant balance, and inflammation. This study aimed to study the phytochemical composition of date seeds of Phoenix dactylifera (DSPE) by GC-MS analysis and to assess the in vitro antioxidant, anticoagulant and ACE activities.Methods: The hepato and cardiotoprotective effect against HEP-induced toxicity in rats have been assessed using biochemical, histological and computational assays.Results: HEP increased the body weight, associated significant increases in total cholesterol, triglycerides, total and direct bilirubin, alkaline phosphatase, creatinine kinase-MB, ACE, and troponin-T, exhibited changes in ECG pattern, including ST-segment elevation, and increased rate of TBARS with decreases in the antioxidant enzymatic. DSPE improved these biomarkers alterations through anti-oxidative and anti-coagulant activities, which were confirmed by histopathological examinations. The computational findings supported the in vivo results and showed that DSPE compounds bound Hypoxia-Inducible Factor (HIF-1α) and Insulin-Like Growth Factor (IGF1) with acceptable affinities and molecular interactions.Conclusion: DSPE had hepato and cardioprotective effects against HEP-induced heart and liver injuries. DSPE can be used to prevent acute thrombosis due to its different bioactive compounds.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"859-873"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Qualitative study on cancer diagnosis and primary caregiver coping experience based on infra-red thermography: Impact of protein metabolism and immune function. 基于红外热成像的癌症诊断和主要照顾者应对经验的定性研究：蛋白质代谢和免疫功能的影响。

IF 2.7 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-09-29 DOI: 10.1080/13813455.2025.2567347

Liu Jia, Zeng Lingpiao, Hu Jiayin, Huang Qiyun, Yang Yirong

{"title":"Qualitative study on cancer diagnosis and primary caregiver coping experience based on infra-red thermography: Impact of protein metabolism and immune function.","authors":"Liu Jia, Zeng Lingpiao, Hu Jiayin, Huang Qiyun, Yang Yirong","doi":"10.1080/13813455.2025.2567347","DOIUrl":"https://doi.org/10.1080/13813455.2025.2567347","url":null,"abstract":"Traditional cancer diagnosis methods include imaging examinations, biopsy, etc., but these methods are often invasive, time-consuming, and costly. This study aims to explore the application effect of infra-red thermography technology in cancer diagnosis and analyse the coping experience of primary caregivers during patient diagnosis and treatment. The data collection methods include semi-structured interviews, observations, and questionnaire surveys. The research results show that infra-red thermography technology has high sensitivity and specificity in cancer diagnosis, which can assist doctors in detecting early signs of tumours. Therefore, cancer diagnosis technology based on infra-red thermography has shown great potential in early detection and is expected to become a beneficial supplement to traditional diagnostic methods. At the same time, caregivers' coping experiences during cancer diagnosis and treatment are complex and diverse, requiring the healthcare system to provide more support and resources to help them better adapt and cope.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-12"},"PeriodicalIF":2.7,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prior resistance training exerts cardioprotection against cardiac remodelling after myocardial infarction. 先前的抗阻训练对心肌梗死后心脏重构具有保护作用。

IF 2.7 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-09-22 DOI: 10.1080/13813455.2025.2548815

Flávio André Silva, Leslie Andrews Portes, Ednei Luiz Antonio, Luis Felipe Neves Dos Santos, Helenita Antonia Oliveira, Ighor Luiz Azevedo Teixeira, André Rodrigues Lourenço Dias, Paulo José Ferreira Tucci, Andrey Jorge Serra

{"title":"Prior resistance training exerts cardioprotection against cardiac remodelling after myocardial infarction.","authors":"Flávio André Silva, Leslie Andrews Portes, Ednei Luiz Antonio, Luis Felipe Neves Dos Santos, Helenita Antonia Oliveira, Ighor Luiz Azevedo Teixeira, André Rodrigues Lourenço Dias, Paulo José Ferreira Tucci, Andrey Jorge Serra","doi":"10.1080/13813455.2025.2548815","DOIUrl":"https://doi.org/10.1080/13813455.2025.2548815","url":null,"abstract":"Background: The cardioprotective properties of resistance training (RT) in infarcted rats have been poorly investigated. This study aimed to evaluate the effects of eight weeks of RT prior myocardial infarction (MI) in rats. Method: Groups: SSh: sedentary sham surgery; SMI: sedentary MI; TMI: trained MI. At the end of the eighth week, the animals underwent either MI or sham surgery and were analysed four weeks later. Results: The TMI presented MI sizes, scar areas, masses of the atria, right ventricle, heart, left atrial area, E wave, and E/A ratio, smaller than the SMI. The protein expression related to Ca2+ handling were not affected by the RE. The maximal load (ML) of the TMI was greater than that of the SMI group. The VO2 peak and maximum speed (Vmax) were lower in the infarcted groups. Conclusion: Prior RT confers cardioprotection against cardiac remodelling by attenuating infarct size progression, myocardial hypertrophy, and diastolic dysfunction.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-10"},"PeriodicalIF":2.7,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of soft tissue hardness changes in cervical lymph node enlargement based on multimodal ultrasound parameters and lipid metabolism regulation. 基于多模态超声参数及脂质代谢调节的颈淋巴肿大软组织硬度变化分析。

IF 2.7 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-09-19 DOI: 10.1080/13813455.2025.2564081

Shuigen Ye, Lihua Xu, Yin Fang, Jianpei Ye, Suzhi Hu

{"title":"Analysis of soft tissue hardness changes in cervical lymph node enlargement based on multimodal ultrasound parameters and lipid metabolism regulation.","authors":"Shuigen Ye, Lihua Xu, Yin Fang, Jianpei Ye, Suzhi Hu","doi":"10.1080/13813455.2025.2564081","DOIUrl":"https://doi.org/10.1080/13813455.2025.2564081","url":null,"abstract":"Lipoprotein metabolic regulation plays a vital role in human health and disease, with its abnormalities closely associated with the onset and progression of various disorders. In cases of lymphadenopathy, this study aimed to develop a linear model based on multimodal ultrasound parameters and lipoprotein metabolic regulation, predicting changes in intraluminal and perilymphatic tissue stiffness during cervical lymphadenopathy to provide clinical guidance for assessing lymph node characteristics. All patients underwent multimodal ultrasound examinations including conventional 2D ultrasound, colour Doppler ultrasound, and elastography. The linear model developed based on these factors demonstrated high predictive power, indicating that changes in lipoprotein metabolism are closely linked to the pathophysiological processes of lymph nodes. In lymphadenopathy, lipoprotein metabolic regulation affects local inflammatory responses and extracellular matrix remodelling, thereby influencing lymph node stiffness and function. Additionally, lipoprotein regulation indirectly impacts lymph node hardness by modulating angiogenesis and extracellular matrix remodelling.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-8"},"PeriodicalIF":2.7,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metal ions and colorectal cancer: unlocking the secrets of tumour cell death. 金属离子与结直肠癌：解开肿瘤细胞死亡的秘密。

IF 2.7 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-09-05 DOI: 10.1080/13813455.2025.2556008

Yuhao Yu, Jiayan Luo, Haizhong Jiang, Haojun Song, Bujiang Wang

{"title":"Metal ions and colorectal cancer: unlocking the secrets of tumour cell death.","authors":"Yuhao Yu, Jiayan Luo, Haizhong Jiang, Haojun Song, Bujiang Wang","doi":"10.1080/13813455.2025.2556008","DOIUrl":"https://doi.org/10.1080/13813455.2025.2556008","url":null,"abstract":"Background: Colorectal cancer (CRC) is a highly prevalent and fatal malignancy worldwide. Despite advancements in early screening techniques and treatments, the prognosis for patients remains suboptimal. Studies have shown that metal ions play crucial roles in the occurrence, progression, and treatment of CRC.Method: Regulating the concentrations of specific metal ions within tumour cells can promote cancer cell death and increase the effectiveness of chemotherapy, radiotherapy, targeted therapy, and immunotherapy.Results: This article reviews the relationships between metal ions such as iron, copper, potassium, calcium, magnesium, and zinc and CRC, summarising recent research progress from mechanistic studies to clinical applications. Magnesium ions inhibit CRC development and metastasis by regulating various signalling pathways can either promote or inhibit tumour-associated gene expression.Conclusion: Therefore, modulating the concentrations of relevant metal ions within tumour cells could be a potential therapeutic direction for CRC, providing new theoretical foundations and strategies for clinical treatment.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-16"},"PeriodicalIF":2.7,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cross-sectional study on the connection between collateral status and cognitive impairment after stroke based on neural regulation and protein metabolism. 基于神经调节和蛋白质代谢的脑卒中后侧支状态与认知功能障碍关系的横断面研究。

IF 2.7 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-09-05 DOI: 10.1080/13813455.2025.2556009

Shufen Zhang, Jiwei Cheng, Chuansen Liu, Yunyun Zhang

{"title":"Cross-sectional study on the connection between collateral status and cognitive impairment after stroke based on neural regulation and protein metabolism.","authors":"Shufen Zhang, Jiwei Cheng, Chuansen Liu, Yunyun Zhang","doi":"10.1080/13813455.2025.2556009","DOIUrl":"https://doi.org/10.1080/13813455.2025.2556009","url":null,"abstract":"Background: Post-stroke cognitive impairment (PSCI), a common complication following stroke, significantly impacts patients' quality of life and prognosis. Research indicates that neuroregulation and protein metabolic disorders play crucial roles in the development of PSCI.Purpose: This study aimed to evaluate the reliability of the Regional Meningoarterial Score (rLMC) in determining collateral circulation status in acute ischaemic stroke patients.Method: Participants were selected based on specific criteria including MRI-detected recent cerebral infarction, absence of prior large-scale subcortical infarction or haemorrhage, and no history of Alzheimer's disease or cognitive impairment.Results: The results showed that cognitive impairment group (CI group) exhibited significantly lower serum acetylcholine levels compared to normal control group (CN group), while β-amyloid protein levels were markedly higher. CI group also demonstrated reduced expression of neuroregulatory factors.Conclusion: These findings demonstrate that neuroregulatory factors and protein metabolites can serve as potential biomarkers for early diagnosis and intervention, effectively predicting post-stroke cognitive impairment.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-9"},"PeriodicalIF":2.7,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0