Archives of Physiology and Biochemistry最新文献_第3页

Glucose metabolism in the perfused liver did not improve with resistance training in male Swiss mice under caloric restriction. 雄性瑞士小鼠在热量限制条件下进行阻力训练后，灌注肝脏中的葡萄糖代谢并没有得到改善。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-04-01 Epub Date: 2024-10-11 DOI: 10.1080/13813455.2024.2413626

Julio Ernesto Perego Junior, Kauane Tomazi Silva, Ana Luiza Balani Rando, Mateus Sousa Lima, Rosângela Fernandes Garcia, Maria Montserrat Diaz Pedrosa

{"title":"Glucose metabolism in the perfused liver did not improve with resistance training in male Swiss mice under caloric restriction.","authors":"Julio Ernesto Perego Junior, Kauane Tomazi Silva, Ana Luiza Balani Rando, Mateus Sousa Lima, Rosângela Fernandes Garcia, Maria Montserrat Diaz Pedrosa","doi":"10.1080/13813455.2024.2413626","DOIUrl":"10.1080/13813455.2024.2413626","url":null,"abstract":"Context: Energy homeostasis is a primary factor for the survival of mammals. Many tissues and organs, among which is the liver, keep this homeostasis in varied circumstances, including caloric restriction (CR) and physical activity.Objective: This study investigated glucose metabolism using the following groups of eight-week-old male Swiss mice: CS, sedentary and fed freely; RS, sedentary and RT, trained, both under 30% CR (n = 20-23 per group).Results: Organs and fat depots of groups RS and RT were similar to CS, although body weight was lower. CR did not impair training performance nor affected systemic or hepatic glucose metabolism. Training combined with CR (group RT) improved in vivo glucose tolerance and did not affect liver gluconeogenesis.Conclusions: The mice tolerated the prolonged moderate CR without impairment of their well-being, glucose homeostasis, and resistance training performance. But the higher liver gluconeogenic efficiency previously demonstrated using this training protocol in mice was not evidenced under CR.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"306-315"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142399141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combined swimming with melatonin protects against behavioural deficit in cerebral ischemia-reperfusion injury induced rats associated with modulation of Mst1- MAPK -ERK signalling pathway. 游泳与褪黑素联合使用可防止脑缺血再灌注损伤大鼠的行为缺陷，这与调节 Mst1- MAPK -ERK 信号通路有关。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-04-01 Epub Date: 2024-08-17 DOI: 10.1080/13813455.2024.2392186

Samah Mahmoud Abdelaal, Marwa Mohamed Abdel Rahman, Lamiaa Mohamed Mahmoud, Laila Ahmed Rashed, Tarek Ibrahim Abd El-Galil, Manal Moustafa Mahmoud

{"title":"Combined swimming with melatonin protects against behavioural deficit in cerebral ischemia-reperfusion injury induced rats associated with modulation of Mst1- MAPK -ERK signalling pathway.","authors":"Samah Mahmoud Abdelaal, Marwa Mohamed Abdel Rahman, Lamiaa Mohamed Mahmoud, Laila Ahmed Rashed, Tarek Ibrahim Abd El-Galil, Manal Moustafa Mahmoud","doi":"10.1080/13813455.2024.2392186","DOIUrl":"10.1080/13813455.2024.2392186","url":null,"abstract":"Background: The inconvenience of social and behavioural deficits after cerebral ischaemia reperfusion (I/R) injury is still not well documented.Aim: We aimed to study the protective effect of preconditioning swimming exercise combined with melatonin against cerebral I/R induced injury.Methodology: Sixty rats were allocated into 6 groups; groups I and II served as control. Groups 3,4,5,6 subjected to bilateral carotid ligation for 30 minutes (min.) followed by reperfusion. Group 3 left untreated while groups 4 and 6; underwent swimming exercise 30 min/day, five days a week for three weeks before the surgery. Groups 5 and 6 treated with melatonin 30 minutes before the operation, then, all rats in groups 4, 5,6 were subjected to I/R. After that, groups 5 and 6 treated with 2nd dose of melatonin 30 minutes after reperfusion.Results: Combined strategy exhibited the most neuroprotective effect through prevention of cerebral I/R induced inflammation, oxidative stress and apoptosis with subsequent improvement in socio behaviour deficits and enhanced Glial cell proliferative capacity.Conclusion: The protective contribution of combined strategy is associated with modulation in Macrophage-stimulating 1/mitogen-activated protein kinase/extracellular signal-regulated kinase (MST1/MAPK/ERK) pathway which may explain, at least in part, its protective potential.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"119-134"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141995156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Network pharmacology and in silico study of quercetin and structurally similar flavonoids as osteogenesis inducers that interact with oestrogen receptors. 槲皮素和结构相似的类黄酮作为与雌激素受体相互作用的成骨诱导剂的网络药理学和计算机研究。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-03-31 DOI: 10.1080/13813455.2025.2483910

Mohammad-Sadegh Lotfi, Hamidreza Jamali, Fatemeh B Rassouli

{"title":"Network pharmacology and in silico study of quercetin and structurally similar flavonoids as osteogenesis inducers that interact with oestrogen receptors.","authors":"Mohammad-Sadegh Lotfi, Hamidreza Jamali, Fatemeh B Rassouli","doi":"10.1080/13813455.2025.2483910","DOIUrl":"https://doi.org/10.1080/13813455.2025.2483910","url":null,"abstract":"Background: Osteoporosis poses a global health challenge, particularly with an ageing population. Quercetin, isorhamnetin, avicularin, isoquercetin, quercitrin, and taxifolin are natural flavonoids with similar structure that induce ontogenesis.Methods: In the present study, proteins in oestrogen signalling and bone morphogenesis were analysed, and hub genes were identified with Cytoscape, followed by pathway analysis. Then, molecular targets of flavonoids and osteoporosis-related targets were identified, and overlaps were detected. Molecular docking and dynamics simulations assessed flavonoid interactions with ERs.Results: The study identified 14 gene products linked to osteoporosis, including ESR1 and ESR2. Enrichment analyses confirmed ESR involvement in various biological processes. SwissTargetPrediction highlighted quercetin and isorhamnetin as favourable targets for ESR1 and ESR2. Molecular docking and dynamics revealed favourable and stable binding of flavonoids to ERα and ERβ.Conclusion: These interactions suggest therapeutic potential of natural flavonoids for osteoporosis treatment by targeting ERs, laying a foundation for future research in preclinical and clinical settings.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-12"},"PeriodicalIF":2.5,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neem seed protein hydrolysates alleviate iron-induced cardiac injury via effects on angiotensin-converting enzyme, purinergic enzymes, redox balance, and lipid metabolism. 印度楝籽蛋白水解物通过影响血管紧张素转换酶、嘌呤能酶、氧化还原平衡和脂质代谢来减轻铁诱导的心脏损伤。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-03-28 DOI: 10.1080/13813455.2025.2483912

Marvellous A Acho, Ochuko L Erukainure, Veronica F Salau, Osarenkhoe O Osemwegie, Eric Amonsou, Rotimi O Arise

{"title":"Neem seed protein hydrolysates alleviate iron-induced cardiac injury via effects on angiotensin-converting enzyme, purinergic enzymes, redox balance, and lipid metabolism.","authors":"Marvellous A Acho, Ochuko L Erukainure, Veronica F Salau, Osarenkhoe O Osemwegie, Eric Amonsou, Rotimi O Arise","doi":"10.1080/13813455.2025.2483912","DOIUrl":"https://doi.org/10.1080/13813455.2025.2483912","url":null,"abstract":"This study assessed the cardioprotective effects of <1 kDa peptide fractions from neem seed protein hydrolysates (NSPHs) in cardiac tissues ex vivo. Oxidative injury was induced in cardiac tissues from male Wister rats by incubating with 0.1 mM FeSO4 (pro-oxidant) for 30 minutes. Untreated tissues lacked peptide fractions, while normal control tissues lacked peptide and pro-oxidant. Treatment with the peptides increased the activities/levels of catalase, superoxide dismutase, ENTPDase, 5'NTPDase, glutathione, and HDL-cholesterol. Conversely, the levels/activities of malondialdehyde, nitric oxide, cholesterol, LDL-cholesterol, ACE, acetylcholinesterase, ATPase decreased following treatment with NSPH peptide fractions. Furthermore, the peptides depleted oxidative metabolites, while concomitantly inactivating plasmalogen synthesis and beta-oxidation of long-chain saturated fatty acids. These findings suggest that <1 kDa peptide fractions from neem seed protein hydrolysates have cardioprotective properties, potentially offering a natural therapeutic option for managing oxidative cardiac dysfunction through the regulation of oxidative stress, cholinesterase and purinergic activities, and lipid metabolism.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-13"},"PeriodicalIF":2.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-atherogenic properties of Plectranthus glandulosus Hook. F. (Lamiaceae) leaves through lipid profile regulation, oxidative stress reduction, and aorta media thickening attenuation in high-fat diet-fed Sprague-Dawley rats. Plectranthus glandulosus Hook.F.（唇形科）叶片通过调节高脂饮食喂养的 Sprague-Dawley 大鼠的血脂状况、减少氧化应激和减轻主动脉介质增厚的作用。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-03-14 DOI: 10.1080/13813455.2025.2476644

Djamila Zouheira, Anu Kajal, Moïse Legentil Nchouwet, Sylviane Laure Poualeu Kamani, Lauve Rachel Tchokouaha Yamthe, Gabriel Agbor Agbor, Sylvie Lea Wansi Ngnokam, Randhir Singh

{"title":"Anti-atherogenic properties of Plectranthus glandulosus Hook. F. (Lamiaceae) leaves through lipid profile regulation, oxidative stress reduction, and aorta media thickening attenuation in high-fat diet-fed Sprague-Dawley rats.","authors":"Djamila Zouheira, Anu Kajal, Moïse Legentil Nchouwet, Sylviane Laure Poualeu Kamani, Lauve Rachel Tchokouaha Yamthe, Gabriel Agbor Agbor, Sylvie Lea Wansi Ngnokam, Randhir Singh","doi":"10.1080/13813455.2025.2476644","DOIUrl":"https://doi.org/10.1080/13813455.2025.2476644","url":null,"abstract":"This study investigated the anti-atherogenic effects of Plectranthus glandulosus leaves aqueous, hydro-ethanolic extracts, and ethyl acetate fraction at doses of 100, 200, and 400 mg/kg for 21 d. As results, at the dose of 400 mg/kg, the ethyl acetate fraction significantly (p < .001) decreased the level of total cholesterol (112.52 ± 1.21 mg/dL), triglyceride (76.47 ± 0.97 mg/dL), and LDL-C (22.01 ± 2.92 mg/dL). Whereas, a significant (p < .001) increase was observed in the level of HDL-C (74.97 ± 1.99 mg/dL). Moreover, the atherogenic index significantly (p < .001) decreased (0.008 ± 0.00 mg/dL), while the percentage of atherogenic protection increased (99.13 ± 0.78%). The activity of antioxidant enzymes increased significantly (p < .001), while malondialdehyde concentration decreased. The thickening of aorta media (67.27 ± 7.15 µm) was also attenuated significantly (p < .001). Thus, our finding supports the use of Plectranthus glandulosus for future atherosclerosis drug discovery.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-15"},"PeriodicalIF":2.5,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143622990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tumour protein p53-activated lncRNA PGM5-AS1 suppresses lung cancer growth and stemness by targeting R-spondin1 via microRNA-1247-5p. 肿瘤蛋白p53激活的lncRNA PGM5-AS1通过microRNA-1247-5p靶向R-spondin1抑制肺癌的生长和干细胞。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-03-04 DOI: 10.1080/13813455.2025.2459318

Peng Yang, Hong Gu, Xuanqin Wu, Geng Chen, Heng Liu, Zhongliang Chen

{"title":"Tumour protein p53-activated lncRNA PGM5-AS1 suppresses lung cancer growth and stemness by targeting R-spondin1 via microRNA-1247-5p.","authors":"Peng Yang, Hong Gu, Xuanqin Wu, Geng Chen, Heng Liu, Zhongliang Chen","doi":"10.1080/13813455.2025.2459318","DOIUrl":"https://doi.org/10.1080/13813455.2025.2459318","url":null,"abstract":"Objective: This study was to investigated the inhibitory role of the tumour protein p53 (TP53)-activated PGM5-AS1 in lung cancer (LC) cell proliferation, invasion, and CSC-like properties and its underlying mechanisms.Methods: The effect of PGM5-AS1 on LC cell development was determined. Stem cell markers, aldehyde dehydrogenase activity in cells were tested, as well as the ability of stem cells to form spheroids. The interaction of PGM5-AS1 and TP53 was determined. The binding link of PGM5-AS1, miR-1247-5p, and R-spondin1 (RSPO1) was verified.Results: PGM5-AS1 was elevated by a combination of TP53 and PGM5-AS1 promoters. PGM5-AS1 was a molecular sponge of miR-1247-5p in LC cells, and miR-1247-5p targeted RSPO1. Elevating PGM5-AS1 or repressing miR-1247-5p restrained LC cell growth and stemness, which were reversed by depression of RSPO1.Conclusion: This study conveys that TP53-elevated PGM5-AS1 mediates miR-1247-5p to target RSPO1, thereby inhibiting LC growth and stemness, representing a novel avenue for LC therapy.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-13"},"PeriodicalIF":2.5,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143539858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular mechanism of METTL3 regulating hippocampal neuronal injury induced by sepsis-associated encephalopathy. METTL3调节败血症相关脑病海马神经元损伤的分子机制。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-03-02 DOI: 10.1080/13813455.2025.2465337

Qian Zhang, Yan Huo, Runying Zhu, Xujie Zhang, Lingwei Zeng, Zhenjie Hu

{"title":"Molecular mechanism of METTL3 regulating hippocampal neuronal injury induced by sepsis-associated encephalopathy.","authors":"Qian Zhang, Yan Huo, Runying Zhu, Xujie Zhang, Lingwei Zeng, Zhenjie Hu","doi":"10.1080/13813455.2025.2465337","DOIUrl":"https://doi.org/10.1080/13813455.2025.2465337","url":null,"abstract":"Objective: This study explores the mechanism of methyltransferase like 3 (METTL3) on sepsis-associated encephalopathy (SAE)-induced hippocampal neuronal injury.Methods: A murine model of SAE was established by caecal ligation and puncture. Hippocampal cells were induced by lipopolysaccharide (LPS). The mouse survival was observed and behavioural tests evaluated cognitive function. METTL3 and glutamic-oxaloacetic transaminase 1 (GOT1) expressions were detected via RT-qPCR and Western blot. Immunofluorescence staining examined the co-localization of NeuN and METTL3. The m6A enrichment on GOT1 was determined by MeRIP.Results: METTL3 and GOT1 were highly expressed in SAE mice and LPS-stimulated hippocampal cells. SAE mice exhibited cognitive function impairment, reduced survival rate, and decreased neuronal cells. LPS induction increased hippocampal cell apoptosis and enhanced inflammation. Silence of METTL3 reduced hippocampal neuronal injury in SAE mice and LPS-induced hippocampal cell injury.Conclusion: METTL3-mediated m6A modification on GOT1 mRNA elevates GOT1 expression, thereby aggravating SAE-induced hippocampal neuronal injury.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-11"},"PeriodicalIF":2.5,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the clinical significance of BTG1 gene expression and pepsinogen in serum and cancerous tissue and gastric atrophy. BTG1基因表达及胃蛋白酶原在血清、癌组织及胃萎缩中的临床意义

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-02-23 DOI: 10.1080/13813455.2025.2458560

Yousef Paridar, Homa Hosseinpour, Maysam Mard-Soltani, Somayeh Pouria Mehr, Neda Shakerian, Davood Alinezhad Dezfuli, Saeed Khalili, Mohammad Reza Abyaz

{"title":"Evaluation of the clinical significance of BTG1 gene expression and pepsinogen in serum and cancerous tissue and gastric atrophy.","authors":"Yousef Paridar, Homa Hosseinpour, Maysam Mard-Soltani, Somayeh Pouria Mehr, Neda Shakerian, Davood Alinezhad Dezfuli, Saeed Khalili, Mohammad Reza Abyaz","doi":"10.1080/13813455.2025.2458560","DOIUrl":"https://doi.org/10.1080/13813455.2025.2458560","url":null,"abstract":"Introduction: This study aimed to assess the expression changes of BTG1, PGI, and PGII in tissues and serum of patients with gastric cancer, atrophic gastritis, and healthy individuals.Methods: QRT-PCR was used to measure BTG1, PGI, and PGII expression in 30 cancers, 30 atrophic gastritis, and 30 healthy tissue samples. Serum levels of PGI and PGII were measured using ELISA. Statistical tests included the Mann-Whitney U and independent T-test. Covariates like tumour stage and H. pylori status were considered.Results: BTG1 expression was significantly lower in cancer and gastritis tissues. Serum PGI and PGII levels were significantly reduced in cancer patients (P ≤ 0.001).Discussion: The PGI/PGII ratio in serum emerged as a strong non-invasive biomarker for distinguishing cancer from healthy individuals. While BTG1 provides insights into gastric carcinogenesis, its clinical utility is limited due to the need for tissue samples. The serum-based PGI/PGII ratio shows greater promise as a non-invasive screening tool for GC.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-10"},"PeriodicalIF":2.5,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bee bread shows therapeutic and protective effects by alleviating inflammation, oxidative stress, and apoptosis on acetic acid-induced gastric ulcer in rats. 蜜蜂面包对醋酸诱发的大鼠胃溃疡具有治疗和保护作用，能减轻炎症、氧化应激和细胞凋亡。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-02-23 DOI: 10.1080/13813455.2025.2466191

Hatice Colak, Esra Tansu Sarıyer, Meral Yüksel, İlayda Özge Polat, Esra Çikler, Neslihan Öner, Berna Karakoyun

{"title":"Bee bread shows therapeutic and protective effects by alleviating inflammation, oxidative stress, and apoptosis on acetic acid-induced gastric ulcer in rats.","authors":"Hatice Colak, Esra Tansu Sarıyer, Meral Yüksel, İlayda Özge Polat, Esra Çikler, Neslihan Öner, Berna Karakoyun","doi":"10.1080/13813455.2025.2466191","DOIUrl":"https://doi.org/10.1080/13813455.2025.2466191","url":null,"abstract":"Objective: This study investigated bee bread's (BB) protective and therapeutic effects on acetic acid-(AA)-induced gastric ulcers via oxidative stress, DNA damage, inflammation, and apoptosis.Materials and methods: Rats were administered saline-(1ml) or BB-(0.5g/kg/day;1ml) by oral gavage once daily for 10-day following 80% AA-induced chronic ulceration in treatment group. Pretreatment group received saline or BB for 10-day before and 3-day after ulcer induction. Stomachs of decapitated rats were collected for ulcer index, histological and biochemical analyses.Results: BB significantly reduced the gastric ulcer index and levels of chemiluminescence, HMGB-1, IL-6, IL-1ß and IL-8 levels in pretreatment and treatment groups. In BB-pretreated ulcer group, MPO-(salineBB, 39.9±3.7 U/g;22.2±2.2 U/g), caspase-3 (0.40±0.07 ng/g;0.18±0.01 ng/g) and IFN-γ (15.46±1.76;9.51±1.95 ng/g) levels decreased and TNF-α (31.77±5.13;18.94±2.59 ng/g) reduced only in BB-treated ulcer group. MDA, GSH, NRF-2, and 8-OHdG levels remained unchanged.Conclusion: BB has demonstrated protective and therapeutic effects by reducing ROS production, modulating inflammation and apoptosis.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-11"},"PeriodicalIF":2.5,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The protective effects of Salusin-α against oxidative stress and inflammatory response in mice with gestational diabetes mellitus (GDM). Salusin-α对妊娠期糖尿病小鼠氧化应激和炎症反应的保护作用。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-02-21 DOI: 10.1080/13813455.2025.2456876

Yujie Zhang, Yi Ye, Xiaorui Jia, Pu Wang, Zheng Xiong, Hui Zhu

{"title":"The protective effects of Salusin-α against oxidative stress and inflammatory response in mice with gestational diabetes mellitus (GDM).","authors":"Yujie Zhang, Yi Ye, Xiaorui Jia, Pu Wang, Zheng Xiong, Hui Zhu","doi":"10.1080/13813455.2025.2456876","DOIUrl":"https://doi.org/10.1080/13813455.2025.2456876","url":null,"abstract":"Gestational diabetes mellitus (GDM) is one of the most prevalent metabolic diseases in pregnant women. In this study, we investigated the effects of Salusin-α in rodent models of GDM. We observed decreased levels of Salusin-α in the placental tissue of GDM mice. Salusin-α alleviated GDM symptoms by reducing blood glucose and increasing serum insulin levels. Further analysis revealed that Salusin-α improved lipid profiles and foetal outcomes in GDM mice. Additionally, Salusin-α mitigated oxidative and nitrosative stress in the placental tissue of GDM mice by enhancing the levels of Vitamin E, Vitamin C, and reduced GSH, while decreasing levels of TBARS and nitric oxide metabolites (nitrite + nitrate = NOx). Salusin-α also reduced the levels of MCP-1 and IL-8. Mechanically, Salusin-α inhibited the activation of p38/NF-κB by reducing phosphorylated p38 and phosphorylated NF-κB p65. In conclusion, our findings support the potential clinical application of Salusin-α as a novel peptide for molecular intervention in GDM.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-10"},"PeriodicalIF":2.5,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0