Archives of Physiology and Biochemistry最新文献_第3页

Molecular pathology and therapeutics of the diabetic foot ulcer; comprehensive reviews. 糖尿病足溃疡的分子病理学和治疗学；综合评论。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2024-10-01 Epub Date: 2023-06-09 DOI: 10.1080/13813455.2023.2219863

Mansi Patel, Vaibhav Patel, Umang Shah, Alkeshkumar Patel

{"title":"Molecular pathology and therapeutics of the diabetic foot ulcer; comprehensive reviews.","authors":"Mansi Patel, Vaibhav Patel, Umang Shah, Alkeshkumar Patel","doi":"10.1080/13813455.2023.2219863","DOIUrl":"10.1080/13813455.2023.2219863","url":null,"abstract":"Diabetes mellitus (DM) is a chronic metabolic condition linked to high blood sugar levels. Diabetes causes complications like neuropathy, nephropathy, and retinopathy. Diabetes foot ulcer (DFU) is a significant and serious wound healing issue resulting from uncontrolled DM. The main causes of the development of the DFU are oxidative stress brought on by the NO moiety, release of pro-inflammatory cytokines like tumour necrosis factor (TNF)-α and interleukin (IL-1), cellular dysfunction, and pathogenic microorganisms including staphylococcus and streptococcus species. The two main types of wounds that are prevalent in DFU patients are neuropathic and neuroischemic. If this wound is not properly treated or cared for, a lower limb may have to be amputated. There are several therapy options for DFU, including antibiotics, debridement, dressings, nano formulations, and growth factor preparations like PDGF-BB, to help the wound heal and prevent amputation. Other novel approaches involved the use of nerve taps, microneedle patches, nanotechnology-based formulations and stem cell applications to promote healing. There are possibilities of drug repurposing for the DFU treatment based on targeting specific enzymes. This article summarises the current pathophysiological aspects of DFU and its probable future targets.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"591-598"},"PeriodicalIF":2.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9600610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Huaiqihuang (HQH) protects podocytes from high glucose-induced apoptosis and inflammation response by regulating PI3K/AKT/mTOR pathway. 怀其黄（HQH）通过调节 PI3K/AKT/mTOR 通路，保护荚膜细胞免受高糖诱导的细胞凋亡和炎症反应的影响。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2024-09-27 DOI: 10.1080/13813455.2024.2407552

Peipei Zhang, Zhilong Liu, Guiqiao Ma, Junwei Wang, Jing Shao, Chaojing Ma, Liping Wang, Chanjuan Ma

{"title":"Huaiqihuang (HQH) protects podocytes from high glucose-induced apoptosis and inflammation response by regulating PI3K/AKT/mTOR pathway.","authors":"Peipei Zhang, Zhilong Liu, Guiqiao Ma, Junwei Wang, Jing Shao, Chaojing Ma, Liping Wang, Chanjuan Ma","doi":"10.1080/13813455.2024.2407552","DOIUrl":"https://doi.org/10.1080/13813455.2024.2407552","url":null,"abstract":"Diabetic kidney disease (DKD) is one of the common microvascular complications of diabetes, and there are still lack of effective treatments. Huaiqihuang (HQH) is a kind of traditional Chinese medicine mixed preparation, which is mainly made of Trametes robiniophila Murr, Fructus Lycii, and Polygonatum sibiricumhas. It has been shown to be effective in the treatment of DKD, but the specific mechanism has not been fully elucidated. Our results showed that HQH increased the protein expressions of synaptopodin, podocin, WT-1, and Bcl-2, decreased the protein expressions of Bax and cleaved-casepase-3, and activated the NF-ĸB and PI3K/AKT/mTOR pathway in MPC5 cells exposed to high-glucose (HG). Real-time PCR results showed that HQH reduced the mRNA expression of TNF-α, IL-1β, MCP-1, and IL-6. In conclusion, our results showed that HQH may attenuate podocyte injury by inhibiting MPC5 cell apoptosis induced by HG and NF-κB-mediated inflammation response through activation of the PI3K/AKT/mTOR pathway.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-8"},"PeriodicalIF":2.5,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142340142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulatory effect and mechanism of CircSEC24A in IL-1β-induced osteoarthritis. CircSEC24A在IL-1β诱导的骨关节炎中的调节作用和机制

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2024-09-27 DOI: 10.1080/13813455.2024.2404975

Yuanrui Wang, Xiaochao Chen, Yongfeng Chen, Qiang Sun, Huayi Wang

引用次数: 0

Effects of exogenous ghrelin treatment on oxidative stress, inflammation and histological parameters in a fat-fed streptozotocin rat model. 外源性胃泌素对脂肪喂养链脲佐菌素大鼠模型氧化应激、炎症和组织学参数的影响

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2024-09-26 DOI: 10.1080/13813455.2024.2407551

Ozlem Ergul Erkec, Zubeyir Huyut, Eda Acikgoz, Mehmet Tahir Huyut

{"title":"Effects of exogenous ghrelin treatment on oxidative stress, inflammation and histological parameters in a fat-fed streptozotocin rat model.","authors":"Ozlem Ergul Erkec, Zubeyir Huyut, Eda Acikgoz, Mehmet Tahir Huyut","doi":"10.1080/13813455.2024.2407551","DOIUrl":"https://doi.org/10.1080/13813455.2024.2407551","url":null,"abstract":"In this study, the anti-inflammatory, antioxidative, and protective effects of ghrelin were investigated in a fat-fed streptozotocin (STZ) rat model and compared with metformin, diabetes and the healthy control groups. Histopathological evaluations were performed on H&E-stained pancreas and brain sections. Biochemical parameters were investigated by enzyme-linked immunosorbent assay. Blood glucose levels were significantly decreased with ghrelin or metformin treatments than the diabetes group. STZ administration increased brain, renal and pancreatic IL-1β, TNF-α and MDA while decreasing GPX, CAT, SOD, and NGF levels. Ghrelin increased renal GPX, CAT, NGF pancreatic GPX, SOD, CAT, NGF and brain SOD, NGF while it decreased renal, pancreatic and brain IL-1β, TNF-α and MDA levels. Ghrelin reduced neuronal loss and degeneration in the cerebral cortex and hippocampus and greatly ameliorated diabetes-related damage in pancreas. In conclusion, the data suggested that ghrelin is an effective candidate as a protectant for reducing the adverse effects of diabetes.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-11"},"PeriodicalIF":2.5,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142340141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic whole-body heat treatment in obese insulin-resistant C57BL/6J mice. 对肥胖的胰岛素抵抗型 C57BL/6J 小鼠进行慢性全身热处理。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2024-09-26 DOI: 10.1080/13813455.2024.2406904

Helena Trevisan Schroeder, Carlos Henrique de Lemos Muller, Maria Inês Lavina Rodrigues, Marcela Alves de Azevedo, Victor de Souza Borges, Cristiana Maria Sponchiado, Paulo Ivo Homem de Bittencourt

{"title":"Chronic whole-body heat treatment in obese insulin-resistant C57BL/6J mice.","authors":"Helena Trevisan Schroeder, Carlos Henrique de Lemos Muller, Maria Inês Lavina Rodrigues, Marcela Alves de Azevedo, Victor de Souza Borges, Cristiana Maria Sponchiado, Paulo Ivo Homem de Bittencourt","doi":"10.1080/13813455.2024.2406904","DOIUrl":"https://doi.org/10.1080/13813455.2024.2406904","url":null,"abstract":"Aim: This study examined the effects of hyperthermic therapy (HT) on mice fed normal chow or a high-fat diet (HFD) for 18 or 22 weeks, undergoing four or eight weekly HT sessions.Methods: Mice were housed within their thermoneutral zone (TNZ) to simulate a physiological response. HFD-induced obesity-related changes, including weight gain, visceral fat accumulation, muscle loss (indicative of obesity sarcopenia), glucose intolerance, and hepatic triglyceride buildup.Main results: HT upregulated HSP70 expression in muscles, mitigated weight gain, normalised QUICK index, and reduced plasma HSP70 concentrations. It also lowered the H-index of HSP70 balance, indicating improved immunoinflammatory status, and decreased activated caspase-1 and proliferative senescence in adipose tissue, both linked to insulin resistance.Conclusion: The findings suggest that even animals on a \"control\" diet but with insufficient physical activity and within their TNZ may experience impaired glycaemic homeostasis.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-18"},"PeriodicalIF":2.5,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142340140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The protective effects of Myrtus communis subsp. on ovariectomized diabetic rats' renal and intestinal tissues: in vivo and in silico approaches. 桃金娘亚种对卵巢切除糖尿病大鼠肾脏和肠道组织的保护作用：体内和硅学方法。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2024-09-26 DOI: 10.1080/13813455.2024.2406895

Onur Ertik, Beril Kadıoğlu-Yaman, Ali Şen, Göksel Şener, Refiye Yanardag

{"title":"The protective effects of Myrtus communis subsp. on ovariectomized diabetic rats' renal and intestinal tissues: in vivo and in silico approaches.","authors":"Onur Ertik, Beril Kadıoğlu-Yaman, Ali Şen, Göksel Şener, Refiye Yanardag","doi":"10.1080/13813455.2024.2406895","DOIUrl":"https://doi.org/10.1080/13813455.2024.2406895","url":null,"abstract":"Introduction: Postmenopausal diabetes is a condition that affects millions of women and their quality of life. Also, kidney and small intestine tissues are damaged due to diabetes. The present study aimed to examine the protective effects of an extract prepared from Myrtus communis leaves on kidney and small intestine tissues against experimentally created postmenopausal diabetes.Methods: For this purpose, experimental rats were randomly divided into six groups (Control; ovariectomy:OVX, diabetic:D, ovariectomy + diabetic:OVX + D, ovariectomy + diabetic + oestrogen:OVX + D+E2, ovariectomy + diabetic + MC: OVX + D+MC) and kidney and small intestine tissues were taken after the experimental procedure.Results: Evaluations of biochemical parameters (glutathione and glutathione-related enzymes, antioxidant enzymes, etc.) showed that MC had a protective effect on kidney and small intestine tissues in diabetes and ovariectomy groups.Conclusion: It can be suggested that MC extract has a protective effect on small intestine and kidney tissues in postmenopausal diabetes and may be a good herbal source for this purpose.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-17"},"PeriodicalIF":2.5,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142340144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-inflammatory activity of the combination Ardisia humilis Vahl. and Curcuma xanthorrhiza Roxb. extract on an osteoarthritis rat model. 蒿草和莪术提取物复方制剂对骨关节炎大鼠模型的抗炎活性。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2024-09-26 DOI: 10.1080/13813455.2024.2406890

Sri Ningsih, Kurnia Agustini, Susi Kusumaningrum, Nisrina Firdausi, Agung Eru Wibowo, Julham Efendi, Ngatinem Ngatinem, Agus Himawan Subiantoro, Suparjo Suparjo, Catherine Catherine, Nasal Auni Rabbina, Anton Bahtiar, Rini Damayanti, KyuJong Lee

{"title":"Anti-inflammatory activity of the combination Ardisia humilis Vahl. and Curcuma xanthorrhiza Roxb. extract on an osteoarthritis rat model.","authors":"Sri Ningsih, Kurnia Agustini, Susi Kusumaningrum, Nisrina Firdausi, Agung Eru Wibowo, Julham Efendi, Ngatinem Ngatinem, Agus Himawan Subiantoro, Suparjo Suparjo, Catherine Catherine, Nasal Auni Rabbina, Anton Bahtiar, Rini Damayanti, KyuJong Lee","doi":"10.1080/13813455.2024.2406890","DOIUrl":"https://doi.org/10.1080/13813455.2024.2406890","url":null,"abstract":"This study aimed to evaluate the anti-inflammatory activity of the combination of Ardisia humilis Vahl. and Curcuma xanthorrhiza Roxb. (AC) extract in monosodium iodoacetate (MIA)-induced osteoarthritis (OA) rat model. AC was administered orally to OA rats (240, 480, and 960 mg/kg bw) for three weeks. The control and model groups comprised OA rats treated with diclofenac sodium and carrier, respectively. AC-treated rats exhibited a significant reduction in oedema volume compared to those of the model group (p < 0.05). Notably, AC, at 960 mg/kg bw, significantly decreased inflammatory cytokines TNF-α and IL-1β, along with matrix metalloproteinase-9 (MMP-9) levels compared to those of the model group (p < 0.05). AC's attenuation of OA progression was also observed through haematoxylin and eosin (H&E) and Safranin O-fast green analysis. A phytochemical study showed AC contained phenolic, flavonoid, curcumin, demethoxycurcumin, and bisdemethoxycurcumin compounds. This study concludes that AC alleviated OA progression through anti-inflammatory effects and depressed MMP-9 levels.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-11"},"PeriodicalIF":2.5,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142340138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artichoke leaf hydroethanolic extract reduces neuropathic pain in a rat model of chronic constriction injury via attenuating the sciatic nerve oxidative stress. 朝鲜蓟叶水乙醇提取物可通过减轻坐骨神经氧化应激减轻慢性收缩损伤模型大鼠的神经痛。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2024-09-25 DOI: 10.1080/13813455.2024.2406898

Mohammad Mehdi Haghighat Lari, Mohammad Reza Bakhoda, Mohammad Shabani, Mohsen Taghizadeh, Fereshteh Bahmani, Gholamali Hamidi, Fatemeh Aghighi, Sayyed Alireza Talaei

{"title":"Artichoke leaf hydroethanolic extract reduces neuropathic pain in a rat model of chronic constriction injury via attenuating the sciatic nerve oxidative stress.","authors":"Mohammad Mehdi Haghighat Lari, Mohammad Reza Bakhoda, Mohammad Shabani, Mohsen Taghizadeh, Fereshteh Bahmani, Gholamali Hamidi, Fatemeh Aghighi, Sayyed Alireza Talaei","doi":"10.1080/13813455.2024.2406898","DOIUrl":"https://doi.org/10.1080/13813455.2024.2406898","url":null,"abstract":"Neuropathic pain, a nerve damage consequence, presents symptoms such as dysesthesia, hyperalgesia, and allodynia. This study aimed to evaluate the alleviating potential of artichoke leaf extract in neuropathic pain induced by chronic constriction injury (CCI) of the sciatic nerve in male rats. The hydroethanolic extract of artichoke leaf was administered via gavage at doses of 200, 400, and 800 mg/kg for 21 days. Behavioural tests were conducted on days 1, 4, 7, 14, and 21 post-surgeries. Only the dose of 800 mg/kg significantly reduced thermal hyperalgesia and allodynia from day 14 and mechanical allodynia from day 7, and the other doses did not affect behaviours. Biochemical analysis showed that artichoke extract decreased lipid peroxidation and restored antioxidant enzyme activities (SOD and GPx) in the sciatic nerve tissue. In conclusion, artichoke leaf extract administration diminishes neuropathic pain-related behaviours by enhancing antioxidant capacity and reducing oxidative stress in the rats' sciatic nerve.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-7"},"PeriodicalIF":2.5,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142340139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Costunolide, an effective agent against oxidative damage, apoptosis and autophagy in the ovarian torsion/detorsion model. 在卵巢扭转/剥离模型中有效抑制氧化损伤、细胞凋亡和自噬的药物--Costunolide。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2024-09-23 DOI: 10.1080/13813455.2024.2407548

Pakistan Armin Akış, Ayhan Tanyeli, Fazile Nur Ekinci Akdemir, Mustafa Can Güler, Saime Özbek Şebin, Ersen Eraslan, Esra Laloğlu, Selim Çomaklı

{"title":"Costunolide, an effective agent against oxidative damage, apoptosis and autophagy in the ovarian torsion/detorsion model.","authors":"Pakistan Armin Akış, Ayhan Tanyeli, Fazile Nur Ekinci Akdemir, Mustafa Can Güler, Saime Özbek Şebin, Ersen Eraslan, Esra Laloğlu, Selim Çomaklı","doi":"10.1080/13813455.2024.2407548","DOIUrl":"https://doi.org/10.1080/13813455.2024.2407548","url":null,"abstract":"Aim: This study assessed the efficacy of costunolide (COST) against oxidative tissue damage in the ovarian torsion/detorsion (TD) model.Methodology: Animals were randomly assigned to sham, ovarian TD, COST 5 mg/kg + ovarian TD, and COST 10 mg/kg + ovarian TD groups. COST's effectiveness was determined by assessing oxidative stress markers, interleukin levels, and histopathological examinations.Results: Oxidative stress markers were elevated in the ovarian TD group compared to the sham group. COST treatment represented a decline compared to the TD group. Besides, the antioxidant activity was significantly higher in the ovarian TD group than in the sham group. COST treatment improved the antioxidant parameters compared to the TD group. Inflammatory parameters, such as tumour necrosis factor- alpha (TNF-α) and interleukin 1-beta (IL-1β) were higher in the ovarian TD group than the sham group.Conclusion: COST treatment suppressed the proinflammatory cytokine expression compared to the TD group. Histopathological data supported these findings.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-9"},"PeriodicalIF":2.5,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trigonelline alkaloid is effective in preventing doxorubicin-induced lung damage 三尖杉碱能有效预防多柔比星引起的肺损伤

IF 3 4区医学

Archives of Physiology and Biochemistry Pub Date : 2024-09-17 DOI: 10.1080/13813455.2024.2404097

Hamit Uslu, Gözde Atila Uslu, Betül Çiçek, İsmail Bolat, Serkan Yıldırım

引用次数: 0