Archives of Physiology and Biochemistry最新文献_第3页

2-APB restores the conditioning phenomenon in diabetic mice, exposed to cerebral ischaemia-reperfusion injury. 2-APB可恢复糖尿病小鼠脑缺血再灌注损伤后的调节现象。

IF 3.2 4区医学

Archives of Physiology and Biochemistry Pub Date : 2026-08-01 Epub Date: 2026-01-15 DOI: 10.1080/13813455.2025.2612144

Poonam Sharma, Bhupesh Sharma

{"title":"2-APB restores the conditioning phenomenon in diabetic mice, exposed to cerebral ischaemia-reperfusion injury.","authors":"Poonam Sharma, Bhupesh Sharma","doi":"10.1080/13813455.2025.2612144","DOIUrl":"10.1080/13813455.2025.2612144","url":null,"abstract":"Introduction: Diabetes abrogates the neuroprotection caused by ischaemic preconditioning (IPC) during cerebral ischaemia-reperfusion (CI/R) injury. The study investigates the involvement of Inositol 1,4,5-trisphosphate (IP3R) receptors in IPC-mediated neuroprotection during C/R injury in hyperglycaemic conditions.Materials and methods: Swiss Albino mice were administered with streptozotocin (STZ) to induce diabetes. Mice were exposed to CI/R injury via common carotid arteries occlusion (20 min) followed by reperfusion (24 h). For IPC, each mouse was exposed to three-1 min cycles of ischaemia and reperfusion, followed by CI/R injury.Results: CI/R animals showed behavioural, biochemical, and histopathological alterations. IPC was observed to attenuate the CI/R-induced detrimental effects in the normoglycemic animals; however, IPC failed to provide neuroprotection in the hyperglycaemic mice. 2-Aminoethyl diphenyl borinate (inositol 1,4,5-trisphosphate receptor (IP3R) antagonist) administration in IPC hyperglycaemic mice restored the neuroprotective effects of IPC.Conclusion: This suggests the possible role of IP3R antagonism in IPC-mediated neuroprotection during CI/R injury in hyperglycaemic conditions.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"430-444"},"PeriodicalIF":3.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145984394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential benefits of Pterocarpus marsupium heartwood extract on high fat diet induced rodent model of atherosclerosis. 有袋翼柏心材提取物对高脂饮食诱导的动脉粥样硬化啮齿动物模型的潜在益处。

IF 3.2 4区医学

Archives of Physiology and Biochemistry Pub Date : 2026-08-01 Epub Date: 2026-01-07 DOI: 10.1080/13813455.2025.2610474

C Garg, B Mattoo, M A Ansari, M S Arshad, O Alam, M I Alam

{"title":"Potential benefits of Pterocarpus marsupium heartwood extract on high fat diet induced rodent model of atherosclerosis.","authors":"C Garg, B Mattoo, M A Ansari, M S Arshad, O Alam, M I Alam","doi":"10.1080/13813455.2025.2610474","DOIUrl":"10.1080/13813455.2025.2610474","url":null,"abstract":"Atherosclerosis, a chronic inflammatory arterial disease, involves lipid deposition and immune cell infiltration, leading to vascular thickening and dysfunction. This study evaluated the protective effects of Pterocarpus marsupium (PM) heartwood extract, rich in polyphenols and flavonoids, in a high-fat diet (HFD)-induced atherosclerosis model in male Wistar rats. Thirty-six rats were divided into six groups (n = 6), receiving either a normal or HFD, with or without atorvastatin or PM extract. After 8 weeks, hemodynamic, biochemical, oxidative stress, and inflammatory parameters were assessed, along with aortic histology. HFD-fed rats showed elevated heart rate, lipids, liver enzymes, and MDA levels, with histological signs of atherosclerosis. PM treatment significantly reduced triglyceride and MDA levels and modestly improved HDL levels. No significant changes were observed in TNF-α or IL-6. Histology revealed reduced lipid infiltration in PM-treated rats. PM extract exhibited anti-atherogenic and antioxidant effects, warranting further studies to explore its therapeutic potential in cardiovascular disease.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"383-389"},"PeriodicalIF":3.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145916715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AMP-activated protein kinase as a therapeutic target: effects of nano-selenium and thymoquinone in Alzheimer's disease. amp活化蛋白激酶作为治疗靶点：纳米硒和百里醌在阿尔茨海默病中的作用。

IF 3.2 4区医学

Archives of Physiology and Biochemistry Pub Date : 2026-08-01 Epub Date: 2026-03-11 DOI: 10.1080/13813455.2026.2640885

Noha Amr El-Sabbagh, Doha El-Sayed Ellakwa

{"title":"AMP-activated protein kinase as a therapeutic target: effects of nano-selenium and thymoquinone in Alzheimer's disease.","authors":"Noha Amr El-Sabbagh, Doha El-Sayed Ellakwa","doi":"10.1080/13813455.2026.2640885","DOIUrl":"10.1080/13813455.2026.2640885","url":null,"abstract":"Context: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline and complex multifactorial pathogenesis. AMP-activated protein kinase (AMPK) has been identified as a promising molecular target in AD due to its neuroprotective functions, particularly in energy regulation.Objective: To evaluate the effects of nano-selenium and thymoquinone (TQ) on AMPK gene expression in an AD rat model.Subjects and methods: Fifty male albino rats were divided into five groups. Four groups were induced with AD via lipopolysaccharide (LPS) injection, while the control group remained untreated. The experimental groups received nano-selenium, TQ, or a combination of both treatments. AMPK gene expression in brain tissue was measured using real-time PCR analysis.Results: Treatment with nano-selenium, TQ, or their combination significantly upregulated AMPK expression in brain tissue compared to untreated AD rats (p<0.001). The combination therapy produced the highest increase in AMPK expression.Discussion and conclusion: Nano-selenium and TQ enhance AMPK gene expression in AD, suggesting a potential therapeutic mechanism involving AMPK-related pathways.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"470-480"},"PeriodicalIF":3.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polygonatum kingianum alleviates diabetic inflammation via the Mef2d/Rufy4-autophagy axis to drive macrophage M2 polarisation. 黄精通过Mef2d/ rufy4自噬轴驱动巨噬细胞M2极化减轻糖尿病炎症。

IF 3.2 4区医学

Archives of Physiology and Biochemistry Pub Date : 2026-08-01 Epub Date: 2026-01-06 DOI: 10.1080/13813455.2025.2612080

Yan Gao, Zhengfeng Liang, Shuhui Ouyang, Jingsong Cao

{"title":"Polygonatum kingianum alleviates diabetic inflammation via the Mef2d/Rufy4-autophagy axis to drive macrophage M2 polarisation.","authors":"Yan Gao, Zhengfeng Liang, Shuhui Ouyang, Jingsong Cao","doi":"10.1080/13813455.2025.2612080","DOIUrl":"10.1080/13813455.2025.2612080","url":null,"abstract":"Chronic inflammation associated with abnormal activation of macrophages is an important promoter of type 2 diabetes (T2D) and its complications. However, there are no effective strategies for mitigating chronic inflammation. This study demonstrated that Polygonatum kingianum (P.K.) can promote macrophages M2 polarisation and increase the expression of anti-inflammatory cytokines. The mechanism involved P.K. upregulation of Mef2d expression, a key gene involved in M2 macrophage polarisation. Mef2d targeted and promoted the expression of Rufy4, thereby activating autophagy and ultimately resulting in M2 macrophage polarisation. P.K. significantly increased the number of M2 macrophages in the bone marrow and kidney while concurrently reducing the serum levels of CRP in a murine model of T2D. In summary, this study confirms that P.K. induces macrophage M2 polarisation via the Mef2d-Rufy4-autophagy pathway, which alleviates chronic inflammation associated with T2D. This study lays a foundation for the prevention and treatment of vascular complications in patients with T2D.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"418-429"},"PeriodicalIF":3.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145910192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Statement of Retraction: Long non-coding RNA MEG3 and its genetic variant rs941576 are associated with rheumatoid arthritis pathogenesis in Egyptian patients. 撤回声明：长链非编码RNA MEG3及其遗传变异rs941576与埃及患者的类风湿关节炎发病有关。

IF 3.2 4区医学

Archives of Physiology and Biochemistry Pub Date : 2026-07-31 DOI: 10.1080/13813455.2026.2710002

引用次数: 0

Trophoblast invasion dynamics improve through protein-mediated enhancement of uterine vascular remodelling pathways. 滋养细胞侵袭动力学通过蛋白质介导增强子宫血管重构途径改善。

IF 3.2 4区医学

Archives of Physiology and Biochemistry Pub Date : 2026-07-30 DOI: 10.1080/13813455.2026.2699136

Chenghong Xie, Jingqiong Zhan, Yufang Xiang

{"title":"Trophoblast invasion dynamics improve through protein-mediated enhancement of uterine vascular remodelling pathways.","authors":"Chenghong Xie, Jingqiong Zhan, Yufang Xiang","doi":"10.1080/13813455.2026.2699136","DOIUrl":"https://doi.org/10.1080/13813455.2026.2699136","url":null,"abstract":"Background: In early pregnancy, trophoblast invasion and uterine vascular remodelling must be tightly regulated to ensure maternal-foetal circulation. Inhibition of these processes causes preeclampsia, foetal development retardation, and recurrent pregnancy loss. It is unclear whether molecular regulators control trophoblast invasiveness and uterine vascular adaption, despite much investigation. Methods: Here, a Protein-Mediated Vascular Remodelling Enhancement (PM-VRE) technique is proposed to examine trophoblast invasion mediated by particular regulatory proteins by increasing uterine vascular remodelling. Protein expression profiling and pathway interaction analysis comprise PM-VRE. Results: Experiments show protein signalling drives endothelial transformation, artery remodelling, and trophoblast migration, with upregulated angiogenic and matrix pathways enabling vascular adaptation. It achieves higher trophoblast invasion depths (∼195-210 µm), enhanced endothelial responsiveness (up to 95%), increased ECM remodelling activity (∼75-80), greater vascular resistance reduction (∼78%), and improved placental perfusion stability (up to 90). Conclusion: PM-VRE provides an effective framework for identifying molecular regulators of trophoblast invasion and uterine vascular remodeling, offering insights into mechanisms underlying placental development and pregnancy disorders associated with impaired placentation.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-15"},"PeriodicalIF":3.2,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148618263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Statement of Retraction: Long non-coding RNA SNHG15 regulates cardiomyocyte apoptosis after hypoxia/reperfusion injury via modulating miR-188-5p/PTEN axis. 撤回声明：长链非编码RNA SNHG15通过调节miR-188-5p/PTEN轴调控缺氧/再灌注损伤后心肌细胞凋亡。

IF 3.2 4区医学

Archives of Physiology and Biochemistry Pub Date : 2026-07-28 DOI: 10.1080/13813455.2026.2710004

引用次数: 0

Correction. 修正。

IF 3.2 4区医学

Archives of Physiology and Biochemistry Pub Date : 2026-07-25 DOI: 10.1080/13813455.2026.2709942

引用次数: 0

Physiological impact of Ba Duan Jin versus conventional breathing exercises on pulmonary function and respiratory biomarkers in chronic obstructive pulmonary disease. 八段金与常规呼吸练习对慢性阻塞性肺疾病患者肺功能和呼吸生物标志物的生理影响

IF 3.2 4区医学

Archives of Physiology and Biochemistry Pub Date : 2026-07-25 DOI: 10.1080/13813455.2026.2701305

Songfeng Jin, Xuefeng Yu, Jiangtao Yin, Yujuan Guan, Dinglei Li, Xiaohuan Ding, Yinghai Cui

{"title":"Physiological impact of Ba Duan Jin versus conventional breathing exercises on pulmonary function and respiratory biomarkers in chronic obstructive pulmonary disease.","authors":"Songfeng Jin, Xuefeng Yu, Jiangtao Yin, Yujuan Guan, Dinglei Li, Xiaohuan Ding, Yinghai Cui","doi":"10.1080/13813455.2026.2701305","DOIUrl":"https://doi.org/10.1080/13813455.2026.2701305","url":null,"abstract":"Background: Chronic obstructive pulmonary disease (COPD) is a common, manageable chronic respiratory disorder characterised by persistent airflow limitation. This study evaluated the effectiveness of Ba Duan Jin exercise in improving respiratory function in COPD patients.Methods: One hundred COPD patients were randomly assigned to a Ba Duan Jin group or a control group (50 each). The Ba Duan Jin group practiced for 30 minutes, five days per week, for 12 weeks, while the control group received no exercise intervention. Outcomes including FEV1%, COPD Assessment Test (CAT), Traditional Chinese Medicine (TCM) syndrome scores, and 6-minute walk distance (6MWD) were assessed at baseline, weeks 4, 8, 12, and at 24-week follow-up.Results: The Ba Duan Jin group showed significant improvements in lung function, exercise capacity, dyspnoea, and quality of life compared to controls, with benefits maintained at follow-up (p < 0.05-0.01).Conclusion: Ba Duan Jin significantly improves respiratory function and quality of life in COPD patients.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-12"},"PeriodicalIF":3.2,"publicationDate":"2026-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148583357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MiR-339-5p promotes hepatic steatosis and inflammation in MASLD by targeting SORT1. MiR-339-5p通过靶向SORT1促进MASLD中的肝脂肪变性和炎症。

IF 3.2 4区医学

Archives of Physiology and Biochemistry Pub Date : 2026-07-25 DOI: 10.1080/13813455.2026.2703192

Bing Zhang, Yinge Zhang, Xuejun Xie

{"title":"MiR-339-5p promotes hepatic steatosis and inflammation in MASLD by targeting SORT1.","authors":"Bing Zhang, Yinge Zhang, Xuejun Xie","doi":"10.1080/13813455.2026.2703192","DOIUrl":"https://doi.org/10.1080/13813455.2026.2703192","url":null,"abstract":"Objective: This study investigated the clinical significance of serum miR-339-5p in MASLD and explored its molecular mechanisms in hepatic steatosis and inflammation.Methods: 87 MASLD patients (Np-MASLD, n = 51; MASH-F, n = 36) were enrolled. Serum miR-339-5p was quantified and correlated with clinical indices. In vitro studies used FFA-treated HepG2 cells to assess miR-339-5p and SORT1 effects on lipid accumulation, inflammation.Results: Serum miR-339-5p was significantly elevated in MASLD, correlating positively with disease severity, and served as an independent risk factor for MASH-F progression. In HepG2 cells, miR-339-5p overexpression exacerbated FFA-induced lipid accumulation and IL-6/TNF-α secretion, whereas its inhibition exerted protective effects. SORT1 was validated as a direct target of miR-339-5p and was downregulated in MASLD. miR-339-5p suppressed AMPK phosphorylation and promoted NF-κB activation by targeting SORT1.Conclusion: Elevated miR-339-5p promotes hepatocyte lipid accumulation and inflammation in MASLD, potentially by targeting SORT1.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-13"},"PeriodicalIF":3.2,"publicationDate":"2026-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148590154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0