Archives of Physiology and Biochemistry最新文献_第3页

Beclin1/LC3II/P62 autophagy pathway activation is involved in the protective action of C-peptide against prostate injury in a rat model of type 1 diabetes. 在 1 型糖尿病大鼠模型中，Beclin1/LC3II/P62 自噬途径的激活参与了 C 肽对前列腺损伤的保护作用。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-06-01 Epub Date: 2024-11-04 DOI: 10.1080/13813455.2024.2422317

Heba A Abdel-Hamid, Manar Fouli Gaber Ibrahim, Doaa Mohamed Elroby Ali, Elshymaa A Abdel-Hakeem

{"title":"Beclin1/LC3II/P62 autophagy pathway activation is involved in the protective action of C-peptide against prostate injury in a rat model of type 1 diabetes.","authors":"Heba A Abdel-Hamid, Manar Fouli Gaber Ibrahim, Doaa Mohamed Elroby Ali, Elshymaa A Abdel-Hakeem","doi":"10.1080/13813455.2024.2422317","DOIUrl":"10.1080/13813455.2024.2422317","url":null,"abstract":"One of the undesirable complications of diabetes is sexual dysfunctions in males which may affect their fertility. This research aims to study the effect of C-peptide administration on the prostate of diabetic rats and focusing on exploring the role of the autophagy pathway in diabetic prostate and whether it is involved in C-peptide action. Forty adult male Wistar albino rats were separated into control group, diabetic group, diabetic + C-peptide and diabetic + C-peptide + 3-Methyladenine (autophagy inhibitor). Serum metabolic parameters and prostatic specific antigen (PSA) were measured. Markers of oxidative stress, inflammation, fibrosis, cell proliferation and cell autophagy were evaluated in prostate tissues using biochemical, western blotting and immunohistochemical techniques. C-peptide administration ameliorated the effects of diabetes on the prostate through its hypoglycaemic, antioxidant, anti-inflammatory, and antiproliferative effects which were reversed with autophagy inhibition. Thus, we concluded that C-peptide prevented the effects of diabetes on the prostate through stimulation of the autophagy pathway.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"419-431"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Saracatinib, a Src kinase inhibitor, enhances the renoprotective effect of metformin and losartan in diabetic nephropathy. Saracatinib是一种Src激酶抑制剂，可增强二甲双胍和氯沙坦对糖尿病肾病的肾保护作用。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-06-01 Epub Date: 2025-01-07 DOI: 10.1080/13813455.2024.2449404

Suzan A Khodir, Eman M Sweed, Mona A Kora, Nader G Zaki, Ghada S Amer, Omnia Ameen

{"title":"Saracatinib, a Src kinase inhibitor, enhances the renoprotective effect of metformin and losartan in diabetic nephropathy.","authors":"Suzan A Khodir, Eman M Sweed, Mona A Kora, Nader G Zaki, Ghada S Amer, Omnia Ameen","doi":"10.1080/13813455.2024.2449404","DOIUrl":"10.1080/13813455.2024.2449404","url":null,"abstract":"Objective: This research assesses renoprotective effects of saracatinib (Src) in diabetic nephropathy (DN) and the potential underlying processes.Materials and methods: Rats were divided into: control, DN, DN + Met + Los, DN + Met + Src, and DN + Met + Los + Src. Rats' ABP, urinary albumin, urinary nephrin, and creatinine clearance were assessed. Blood samples were collected for measuring glycaemic state parameters, renal functions, oxidative stress markers, inflammatory mediators, aldosterone, and lipid profile. Kidneys were extracted for KIM-1 and nephrin gene expression, H&E, Masson's trichrome staining, and immunohistochemical assessment.Results: Significant increases in ABP, urinary albumin and nephrin, glycaemic measurements, urea, creatinine, aldosterone, inflammatory cytokines, MDA, lipids, renal fibrosis, H scores of VEGF and TGF-β, and renal KIM-1 expression were related to DN. However, there was a significant decrease in creatinine clearance, GSH, and nephrin expression in DN group compared with control group.Discussion and conclusion: The combination of metformin (Met), losartan (Los), and Src repaired DN alterations. Adding Src to Met and Los is superior to using them alone.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"467-482"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142943386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Triglycerides and metabolic syndrome: from basic to mechanism - A narrative review. 甘油三酯与代谢综合征：从基础到机制--综述。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-06-01 Epub Date: 2024-11-14 DOI: 10.1080/13813455.2024.2426496

Gayathri S Prabhu, Preethi Lavina Concessao

{"title":"Triglycerides and metabolic syndrome: from basic to mechanism - A narrative review.","authors":"Gayathri S Prabhu, Preethi Lavina Concessao","doi":"10.1080/13813455.2024.2426496","DOIUrl":"10.1080/13813455.2024.2426496","url":null,"abstract":"Content: The impact of triglyceride levels is important to understand the changes in metabolism and structure. With an increase in obesity and hyperlipidemia due to diet; cardiovascular and neuronal structural changes have been shown to be more distinct.Objective: This review aims to discuss the pathophysiology and mechanisms involved in increased levels of triglycerides leading to vascular impairment, metabolic syndrome and cognitive decline.Methods: The literature search was performed using the PubMed, Google scholar and Scopus databases, among which 180 articles were shortlisted based on key words, abstract, materials and methods and results. Among these 74 articles have been cited for the review.Results and discussion: The review discusses the impact of hypertriglyceridemia on metabolism, triglyceride storage, and neurovascular integrity, highlighting mechanisms contributing to vascular dysfunction, metabolic syndrome, and cognitive deterioration.Conclusion: Elevated triglyceride levels are a key factor in altering metabolic pathways and structural integrity in cardiovascular and neuronal systems. This review provides insights into the mechanisms underlying metabolic disorders caused by elevated triglyceride levels, It highlights the need for further studies to provide more supportive evidence and address existing limitations in understanding these changes.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"342-350"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytotoxic properties of Thuya occidentalis hydroalcoholic extract on androgen unresponsive prostate cancer cells. Thuya occidentalis 水醇提取物对雄激素无反应性前列腺癌细胞的细胞毒性特性。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-06-01 Epub Date: 2024-11-20 DOI: 10.1080/13813455.2024.2430488

Gabriela Elisa Hirsch, Mariana Migliorini Parisi, Leo Anderson Meira Martins, Lílian Corrêa Costa-Beber, Cláudia Marlise Balbinotti Andrade, Florencia Mária Barbé Tuana, Silvia Resende Terra, Tassiane Dos Santos Ferrão, Roger Wagner, Tatiana Emanuelli, Fátima Theresinha Costa Rodrigues Guma

{"title":"Cytotoxic properties of Thuya occidentalis hydroalcoholic extract on androgen unresponsive prostate cancer cells.","authors":"Gabriela Elisa Hirsch, Mariana Migliorini Parisi, Leo Anderson Meira Martins, Lílian Corrêa Costa-Beber, Cláudia Marlise Balbinotti Andrade, Florencia Mária Barbé Tuana, Silvia Resende Terra, Tassiane Dos Santos Ferrão, Roger Wagner, Tatiana Emanuelli, Fátima Theresinha Costa Rodrigues Guma","doi":"10.1080/13813455.2024.2430488","DOIUrl":"10.1080/13813455.2024.2430488","url":null,"abstract":"Background: Androgen independent phase in prostate cancer (PCa) commonly limits the therapeutic efficacy. Thuya occidentalis through its main active compound, α-thujone, appears to be an option, considering its anti-proliferative, anti-metastatic and pro-apoptotic effects on hepatocellular carcinoma. However, studies on PCa are limited.Objective: To evaluate if T. occidentalis could be useful against androgen responsive and unresponsive PCa cells.Methods: Androgen responsive (LNCaP) and unresponsive (DU145 and PC3) cell lines were exposed to T. occidentalis hydroalcoholic extract (0.05 mL/mL) for different periods. Further, α-thujone was measured in the extract and tested in the cell lines.Results: T. occidentalis and α-thujone showed the highest cytotoxicity on LNCaP cells. In androgen unresponsive cells, T. occidentalis decreased cell viability and density, and promoted apoptosis, necrosis and cell cycle arrest, possibly associated with Cav-1 downregulation. The α-thujone present in the extract significantly LNCaP cells density, but did not affect DU145 and PC3 cells, suggesting that other compounds may also be cytotoxic to androgen unresponsive cells.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"556-566"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142674398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A herbal approach to diabetic cardiomyopathy: moringa, ginger, and garlic unveiled. 一种治疗糖尿病心肌病的草药：辣木、生姜和大蒜。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-06-01 Epub Date: 2025-01-31 DOI: 10.1080/13813455.2025.2459871

Kaushal Shah, Manjiri Jalgaonkar, Aditi Vyas, Gaurav Doshi, Yogesh A Kulkarni, Alok D Singh, Manisha J Oza

{"title":"A herbal approach to diabetic cardiomyopathy: moringa, ginger, and garlic unveiled.","authors":"Kaushal Shah, Manjiri Jalgaonkar, Aditi Vyas, Gaurav Doshi, Yogesh A Kulkarni, Alok D Singh, Manisha J Oza","doi":"10.1080/13813455.2025.2459871","DOIUrl":"10.1080/13813455.2025.2459871","url":null,"abstract":"Objective: Chronic inflammation contributes to myocardial complications in diabetes, marked by tissue fibrosis, necrosis, and apoptosis. Zingiber officinale, Allium sativum, and Moringa oleifera have individually demonstrated efficacy in diabetes management. In this study, it is hypothesised that a combination of these herbs in a polyherbal formulation would protect against diabetic cardiomyopathy.Materials and methods: Diabetes was induced in male Sprague Dawley rats using strepetozotocin at a single dose of (55 mg/kg of body weight, i.p) in citrate buffer. Polyherbal formulation was administred as a treatment for 8 weeks.Rats receiving treatment with polyherbal formulation showed decreased blood glucose, plasma creatinine, Blood Urea Nitrogen, Creatine kinase- myocardial band, lactate dehydrogenase, aspartate aminotransferase, Troponin-I, NADPH oxidase 4, and Ras-related C3 botulinum toxin substrate-1. In contrast, Superoxide dismutase, catalase, and glutathione enzyme activities were increased.Conclusion: Thus, a polyherbal formulation containing herbs was able to attenuate the progression of diabetes mellitus and diabetic cardiomyopathy.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"539-548"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 修正。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-06-01 Epub Date: 2025-01-22 DOI: 10.1080/13813455.2025.2455266

引用次数: 0

MiR-93 promotes the progression and chemoresistance of diffuse large B-cell lymphoma cells via targeting SMAD5. MiR-93通过靶向SMAD5促进弥漫性大b细胞淋巴瘤的进展和化疗耐药。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-06-01 Epub Date: 2025-04-01 DOI: 10.1080/13813455.2024.2404099

Xiang Fang, Qiang Huang, Li-Jun Dong, Qi-Huan Liu, Xiao-Na Miao, Jian Xiong, Xiao-Duan Jiang, Qiang Yu

引用次数: 0

Self-paced combined training alleviated oxidative stress, inflammatory responses and hyperlipidaemia in people living with multiple sclerosis: a randomised controlled trial. 自定节奏联合训练减轻了多发性硬化症患者的氧化应激、炎症反应和高脂血症：一项随机对照试验

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-06-01 Epub Date: 2024-12-30 DOI: 10.1080/13813455.2024.2440346

Sonda Jallouli, Dana Jallouli, Mariem Damak, Choumous Kallel, Salma Sakka, Bedreddine Jaafar, Chokri Mhiri, Giovanni de Marco, Fatma Ayadi, Omar Hammouda

{"title":"Self-paced combined training alleviated oxidative stress, inflammatory responses and hyperlipidaemia in people living with multiple sclerosis: a randomised controlled trial.","authors":"Sonda Jallouli, Dana Jallouli, Mariem Damak, Choumous Kallel, Salma Sakka, Bedreddine Jaafar, Chokri Mhiri, Giovanni de Marco, Fatma Ayadi, Omar Hammouda","doi":"10.1080/13813455.2024.2440346","DOIUrl":"10.1080/13813455.2024.2440346","url":null,"abstract":"Objective: To examine the effects of self-paced combined high-intensity interval training and resistance training (HIIT-RT) on oxidative stress, inflammation lipid profile and body composition in people with multiple sclerosis (PwMS).Methods: Twenty-three PwMS were randomly assigned to either a control group (CG, n = 12) or a training group (TG, n = 11). The TG performed a 12-week self-paced HIIT-RT (3 times/week). Biomarkers of oxidative stress, inflammation, lipid profile and cellular damage as well as body composition were assessed pre- and post- intervention.Results: Comparatively with CG, the TG showed a decrease in advanced oxidation protein products (p = 0.002, Hedges'g (g) = 1.50) and total thiols (p = 0.0011, g = 1.57), as well as an increase in reduced glutathione (p = 0.03, g = 0.98). Neutrophils (p = 0.003, g = 1.38), lymphocytes (p = 0.038, g = 0.92) and low-density lipoprotein cholesterol (p < 0.001, g = 2.14) decreased in TG compared with CG. There was also a decrease in body weight (p = 0.003, g = 1.39), body mass index (p = 0.002, g = 1.45) and fat mass (p = 0.006, g = 1.27) in TG comparatively with CG.Conclusion: This study revealed the effectiviness of self-paced HIIT-RT in alleviating oxidative stress, inflammatory responses and hyperlipidaemia, as well as in improving body composition in PwMS. This combined training may be recommended to better counteract the damage related to multiple sclerosis.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"432-444"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Statement of Retraction: Comparison and performance evaluation of human bio-field visualization algorithm. 撤回声明：人体生物场可视化算法的比较与性能评价。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-05-31 DOI: 10.1080/13813455.2025.2513141

引用次数: 0

Pharmacotherapeutic potentials of astragalin against cisplatin-induced renal toxicity via regulating Nrf-2/keap-1 pathway. 黄芪甲苷通过调控Nrf-2/ keep -1通路对顺铂所致肾毒性的药物治疗潜力

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-05-26 DOI: 10.1080/13813455.2025.2508419

Muhammad Umar Ijaz, Rubab Furqan, Muhammad Zaid Salar, Ali Hamza, Asma Ashraf, Hamida Hamdi

{"title":"Pharmacotherapeutic potentials of astragalin against cisplatin-induced renal toxicity via regulating Nrf-2/keap-1 pathway.","authors":"Muhammad Umar Ijaz, Rubab Furqan, Muhammad Zaid Salar, Ali Hamza, Asma Ashraf, Hamida Hamdi","doi":"10.1080/13813455.2025.2508419","DOIUrl":"https://doi.org/10.1080/13813455.2025.2508419","url":null,"abstract":"Purpose: Cisplatin (CP) is a chemotherapeutic drug that can produce toxic effects in many organs of the body including kidney. Thus, the current trial was executed for 30 days to assess the alleviative effects of AST to avert CP instigated renal injuries.Materials and methods: Forty-eight male albino rats were allocated into four groups including control, CP (10 mg/kg), CP+AST (10 mg/kg + 50mg/kg) and only AST (50 mg/kg). On the completion of trial, the rats were dissected and further analyses were performed.Results: CP intoxication increased the expressions of pro-apoptotic markers (Caspase-3 and Bax) while reducing the expressions of Nrf-2 and antiapoptotic marker (Bcl-2) and lowering the expressions and activities of antioxidant enzymes i.e., GPx, GSR, CAT, HO-1, GST, SOD and GSH contents. Furthermore, CP intoxication elevated the levels of oxidative stress markers (MDA and ROS) and inflammatory markers (IL-6, IL-1 β, TNF-α, NF-kB and COX-2). CP exposure also disrupted the levels of renal function markers and renal histology. However, AST treatment ameliorated all the renal alterations induced by CP-exposure.Conclusion: Therefore, AST protected the renal tissues from CP-instigated damages due to its antioxidant and reno-protective potential.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-13"},"PeriodicalIF":2.5,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0