Archives of Physiology and Biochemistry最新文献_第9页

Bee bread shows therapeutic and protective effects by alleviating inflammation, oxidative stress, and apoptosis on acetic acid-induced gastric ulcer in rats. 蜜蜂面包对醋酸诱发的大鼠胃溃疡具有治疗和保护作用，能减轻炎症、氧化应激和细胞凋亡。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-02-23 DOI: 10.1080/13813455.2025.2466191

Hatice Colak, Esra Tansu Sarıyer, Meral Yüksel, İlayda Özge Polat, Esra Çikler, Neslihan Öner, Berna Karakoyun

{"title":"Bee bread shows therapeutic and protective effects by alleviating inflammation, oxidative stress, and apoptosis on acetic acid-induced gastric ulcer in rats.","authors":"Hatice Colak, Esra Tansu Sarıyer, Meral Yüksel, İlayda Özge Polat, Esra Çikler, Neslihan Öner, Berna Karakoyun","doi":"10.1080/13813455.2025.2466191","DOIUrl":"https://doi.org/10.1080/13813455.2025.2466191","url":null,"abstract":"Objective: This study investigated bee bread's (BB) protective and therapeutic effects on acetic acid-(AA)-induced gastric ulcers via oxidative stress, DNA damage, inflammation, and apoptosis.Materials and methods: Rats were administered saline-(1ml) or BB-(0.5g/kg/day;1ml) by oral gavage once daily for 10-day following 80% AA-induced chronic ulceration in treatment group. Pretreatment group received saline or BB for 10-day before and 3-day after ulcer induction. Stomachs of decapitated rats were collected for ulcer index, histological and biochemical analyses.Results: BB significantly reduced the gastric ulcer index and levels of chemiluminescence, HMGB-1, IL-6, IL-1ß and IL-8 levels in pretreatment and treatment groups. In BB-pretreated ulcer group, MPO-(salineBB, 39.9±3.7 U/g;22.2±2.2 U/g), caspase-3 (0.40±0.07 ng/g;0.18±0.01 ng/g) and IFN-γ (15.46±1.76;9.51±1.95 ng/g) levels decreased and TNF-α (31.77±5.13;18.94±2.59 ng/g) reduced only in BB-treated ulcer group. MDA, GSH, NRF-2, and 8-OHdG levels remained unchanged.Conclusion: BB has demonstrated protective and therapeutic effects by reducing ROS production, modulating inflammation and apoptosis.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-11"},"PeriodicalIF":2.5,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of cinnamon and statins drug on kidney and liver of rats receiving gentamicin. 肉桂和他汀类药物对庆大霉素大鼠肾脏和肝脏的影响。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-02-20 DOI: 10.1080/13813455.2025.2465335

Abdulrahim Aljamal, Mahmoud Al Shawabkeh, Taha Alqadi

引用次数: 0

Prediction of maximum voluntary ventilation based on forced expiratory volume in athletes. 基于运动员用力呼气量的最大自主通气预测。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-02-17 DOI: 10.1080/13813455.2025.2465333

Irma Lorenzo-Capellá, Juan José Ramos-Álvarez, Elena Jiménez-Herranz, Nicola Maffulli, Enzo Iuliano, Johnny Padulo, Francisco Javier Calderón-Montero

{"title":"Prediction of maximum voluntary ventilation based on forced expiratory volume in athletes.","authors":"Irma Lorenzo-Capellá, Juan José Ramos-Álvarez, Elena Jiménez-Herranz, Nicola Maffulli, Enzo Iuliano, Johnny Padulo, Francisco Javier Calderón-Montero","doi":"10.1080/13813455.2025.2465333","DOIUrl":"10.1080/13813455.2025.2465333","url":null,"abstract":"Objective: Maximum-voluntary-ventilation (MVV) is the maximal volume of which an individual can move by voluntary effort in one minute. It is possible that the first second forced-expiratory-volume (FEV1) could be more to reliable assess respiratory muscle endurance to estimate MVV.Methods: For this aim, 422 athletes (Age 22.9 ± 8.5 years; 98/324 - females/males) were performed a MVV, and FEV1 measurements.Results: The coefficient of determination was R2 = 0.594 between MVV and FEV1, with a predictive equation for overall participants: MVV = (FEV1 × 33.5)+12.7. The robust regression showed a good multiple correlation coefficient (R = 0.815) with the coefficient of determination R2 = 0.661 for the model including FEV1, age and gender as predictors. These equations MVV = (FEV1 X 27.3)+(Age(y) × 1.1)+20.5 and MVV = (FEV1 × 27.3)+(Age(y) × 1.1) were derived for male and female, respectively.Conclusion: FEV1 can predict MVV in different athletes with greater accuracy when stratified per gender. Therefore, this new approach can be used in a short all-out test without stress of the respiratory muscle to predict MVV in athletes.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-10"},"PeriodicalIF":2.5,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic variability of the MTHFR rs1801133 gene polymorphism and role of zinc level in obese patients. 肥胖患者MTHFR rs1801133基因多态性的遗传变异性及锌水平的作用

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-02-14 DOI: 10.1080/13813455.2025.2465338

Haider Ali Alnaji, Alkarar K Abduljaleel, Taif Al-Saadi, Abbas F Almulla

引用次数: 0

Role of berberine in metabolic and bone changes in ovariectomized rats. 小檗碱在去卵巢大鼠代谢和骨变化中的作用。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-02-13 DOI: 10.1080/13813455.2025.2465360

Yasmin Mohammed Eid, Salma Elwy Nassar, Romaysaa Ali El Sherbeny, Ramez Abd-Elmoneim Barhoma

{"title":"Role of berberine in metabolic and bone changes in ovariectomized rats.","authors":"Yasmin Mohammed Eid, Salma Elwy Nassar, Romaysaa Ali El Sherbeny, Ramez Abd-Elmoneim Barhoma","doi":"10.1080/13813455.2025.2465360","DOIUrl":"https://doi.org/10.1080/13813455.2025.2465360","url":null,"abstract":"Background: This study investigates Berberine's (BBR) impact on metabolic and bone changes in ovariectomized rats, a model for postmenopausal conditions.Methods: Sixty adult female rats divided into six groups: control, sham ovariectomized, ovariectomized, and three BBR treated ovariectomized groups (50, 100, and 200 mg/kg/day, for eight weeks). Measurements included serum oestradiol, glucose, HOMA-IR, lipid profile , tumour necrosis factor alpha (TNF-α), oxidative stress markers , osteocalcin (OC), bone-specific alkaline phosphatase (ALP), cross-linked Carboxy-terminal telopeptide of type I collagen (CTX-I), and bone tissue analysis.Results: Ovariectomized rats exhibited significant metabolic and bone deterioration, such as increased glucose, insulin, HOMA IR, total cholestrol (TC), LDL-C, TNF-α, OC, ALP, CTX-I, and MDA levels, alongside decreased oestradiol, HDL-C, and GSH levels, and DNA fragmentation (P < 0.001). BBR treatment showed dose-dependent improvements in all parameters.Conclusion: BBR demonstrates significant ameliorative effects on metabolic and bone health in ovariectomized rats, highlighting its potential therapeutic benefits for postmenopausal conditions.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-9"},"PeriodicalIF":2.5,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cilostazol attenuates mirabegron-induced hepatic and renal toxicity in rats: regulation of metabolic, oxidative, and inflammatory pathways. 西洛他唑减轻米拉贝琼诱导的大鼠肝肾毒性：调节代谢、氧化和炎症途径

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-02-01 Epub Date: 2024-08-07 DOI: 10.1080/13813455.2024.2387700

Mai M Anwar, Ibrahim M Ibrahim Laila

{"title":"Cilostazol attenuates mirabegron-induced hepatic and renal toxicity in rats: regulation of metabolic, oxidative, and inflammatory pathways.","authors":"Mai M Anwar, Ibrahim M Ibrahim Laila","doi":"10.1080/13813455.2024.2387700","DOIUrl":"10.1080/13813455.2024.2387700","url":null,"abstract":"Background: Mirabegron (MIRG) is a type of β3 adrenoceptor agonist that is considered an alternative therapy for the treatment of overactive bladder (OAB) symptoms. Cilostazol (CITZ) is a selective inhibitor of phosphodiesterase (III) that has various pharmacological effects.Objectve: The current study aimed to highlight the regulatory effects of CITZ on MIRG-induced toxicity.Materials and methods: Male rats were divided into six groups. Blood samples were collected to determine different hepatic and kidney function levels along with serum protein electrophoresis and inflammatory factor levels. Histopathological studies and oxidative stress (OS) were also assessed. Kidney and hepatic damage were detected following the administration of MIRG, especially at high doses, due to elevated OS, inflammation, and apoptotic marker levels.Results: Rats receiving CITZ exhibited significant improvements in both hepatic and kidney functions, with decreased inflammation and OS.Conclusion: CITZ administration plays a beneficial role in alleviating hepatic and nephrotoxicity induced by MIRG by inhibiting OS and inflammation.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"81-93"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141896628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of the therapeutic effect of melatonin on deltamethrin applied mouse primary hepatocyte culture. 研究褪黑素对使用溴氰菊酯的小鼠原代肝细胞培养的治疗效果。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-02-01 Epub Date: 2024-08-05 DOI: 10.1080/13813455.2024.2387696

Elif Kaval Oğuz, Ahmet Regaib Oğuz, Necati Özok, Zehra Alkan, Burcu Ergöz Azizoğlu, Elif Örgi, Ayşe Nur Erdemir, Ayşe Yeşilbaş

{"title":"Investigation of the therapeutic effect of melatonin on deltamethrin applied mouse primary hepatocyte culture.","authors":"Elif Kaval Oğuz, Ahmet Regaib Oğuz, Necati Özok, Zehra Alkan, Burcu Ergöz Azizoğlu, Elif Örgi, Ayşe Nur Erdemir, Ayşe Yeşilbaş","doi":"10.1080/13813455.2024.2387696","DOIUrl":"10.1080/13813455.2024.2387696","url":null,"abstract":"Objective: In recent years, it has been known that the melatonin hormone, secreted from the pineal gland, possesses significant antioxidant activity. This study explores the therapeutic effect of melatonin on the deleterious effects of deltamethrin, a pyrethroid pesticide extensively used worldwide, including in Türkiye, on mouse liver cells.Methods: Hepatocytes from Balb/C mice were isolated using a two-stage perfusion method, resulting in over 85% live hepatocytes. The isolated cells were cultured with different doses of deltamethrin (1 and 10 µM) and melatonin (100 µM) for 24 and 48 hours. At the conclusion of the culture period, hepatocytes were extracted at the 24th and 48th hours, and Malondialdehyde (MDA), Total Antioxidant Capacity (TAC), Total Oxidation Status (TOS), and DNA damages (8-hydroxy-2'-deoxyguanosine (8-OHdG)) were examined.Results: While an increase in MDA, TOS, and DNA damage was observed in the deltamethrin-administered groups of hepatocytes, a decrease in TAC level was noted. It was determined that the applied deltamethrin had no effect on cell viability throughout the application period.Conclusion: Furthermore, it was observed that melatonin, when administered concurrently with deltamethrin, reduced the toxic effect of deltamethrin. This study suggests that melatonin has a protective effect against deltamethrin-induced damage in mouse hepatocyte cells.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"63-70"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Salvianolic acid B improves diabetic skin wound repair through Pink1/Parkin-mediated mitophagy. 丹酚酸 B 通过 Pink1/Parkin 介导的有丝分裂改善糖尿病皮肤伤口修复

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-02-01 Epub Date: 2024-08-05 DOI: 10.1080/13813455.2024.2387693

Chunling Zhang, Jie Xiang, Gengxin Wang, Tietao Di, Lu Chen, Wei Zhao, Lianggang Wei, Shiyong Zhou, Xueli Wu, Yun Zhang, Yanhui Wang, Haiyan Liu

{"title":"Salvianolic acid B improves diabetic skin wound repair through Pink1/Parkin-mediated mitophagy.","authors":"Chunling Zhang, Jie Xiang, Gengxin Wang, Tietao Di, Lu Chen, Wei Zhao, Lianggang Wei, Shiyong Zhou, Xueli Wu, Yun Zhang, Yanhui Wang, Haiyan Liu","doi":"10.1080/13813455.2024.2387693","DOIUrl":"10.1080/13813455.2024.2387693","url":null,"abstract":"Diabetic skin wound is a disturbing and rapidly evolving clinical issue. Here, we investigated how salvianolic acid B (Sal B) affected the diabetic wound healing process. Following Sal B administration, histopathological damage was investigated by H&E and Masson staining, and CD34, apoptosis and mitophagy markers were measured by immunofluorescence, immunohistochemistry, and western blotting. Migration, proliferation, and mitochondrial function of high glucose (HG) -induced HMEC-1 cells were measured. The effects of si-Parkin on endothelial cell migration, apoptosis and mitochondrial autophagy were examined. Sal B alleviated inflammatory cell infiltration and promoted angiogenesis in skin wound tissue. Apoptosis and mitophagy were ameliorated by Sal B in diabetic skin wound tissues and HG-induced HMEC-1 cells. Parkin inhibition impaired the migratorypromoted cell apoptosis and inhibited mitophagy of HMEC-1 cells. This finding demonstrated that Sal B promoted diabetic skin wound repair via Pink1/Parkin-mediated mitophagy, improved our understanding of the diabetic wound healing process.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"40-51"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 更正。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-02-01 Epub Date: 2024-08-12 DOI: 10.1080/13813455.2024.2390338

引用次数: 0

Cardiovascular protective effects of cinnamic acid as a natural phenolic acid: a review. 肉桂酸作为一种天然酚酸对心血管的保护作用：综述。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-02-01 Epub Date: 2024-08-05 DOI: 10.1080/13813455.2024.2387694

Leila Safaeian, Mansooreh Asghari-Varzaneh, Seyed-Sadegh Alavi, Mahnaz Halvaei-Varnousfaderani, Ismail Laher

{"title":"Cardiovascular protective effects of cinnamic acid as a natural phenolic acid: a review.","authors":"Leila Safaeian, Mansooreh Asghari-Varzaneh, Seyed-Sadegh Alavi, Mahnaz Halvaei-Varnousfaderani, Ismail Laher","doi":"10.1080/13813455.2024.2387694","DOIUrl":"10.1080/13813455.2024.2387694","url":null,"abstract":"Phenolic acids derived from plants have beneficial effects on cardiovascular diseases (CVD). Cinnamic acid (CA) is a crucial phenolic acid that can form numerous hydroxycinnamic derivate found in many food groups. We review current data on the cardiovascular pharmacology of CA with a focus on CVD and their risk factors including hyperlipidaemia, obesity, hyperglycaemia, cardiomyopathy and myocardial ischaemia, vascular dysfunction, oxidative stress and inflammation. Both in vivo and in vitro laboratory studies demonstrate the lipid-lowering, anti-obesity, anti-hyperglycemic, cardio-protective and vasorelaxant activities of CA. The protective impacts of CA against CVD occur by inhibiting inflammatory, oxidative, and apoptotic pathways, regulating the genes and enzymes involved in glucose and lipid metabolisms, and promoting vasodilation. This review showed that the most studied and prominent effects of CA are anti-hyperlipidemic and anti-diabetic properties. In conclusion, intake of plant foods rich in CA may reduce CVD risk especially through regulating blood glucose and lipids levels.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"52-62"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0