Archives of Physiology and Biochemistry最新文献_第9页

Dipeptedyl peptidase-4 (DPP-4) inhibitor downregulates HMGB1/TLR4/NF-κB signaling pathway in a diabetic rat model of non-alcoholic fatty liver disease. 二表肽酶-4（DPP-4）抑制剂可在糖尿病大鼠非酒精性脂肪肝模型中下调 HMGB1/TLR4/NF-κB 信号通路。

IF 3 4区医学

Archives of Physiology and Biochemistry Pub Date : 2024-02-01 Epub Date: 2021-09-20 DOI: 10.1080/13813455.2021.1975758

Mona M Allam, Reham M Ibrahim, Walaa Bayoumie El Gazzar, Mona A Said

{"title":"Dipeptedyl peptidase-4 (DPP-4) inhibitor downregulates HMGB1/TLR4/NF-κB signaling pathway in a diabetic rat model of non-alcoholic fatty liver disease.","authors":"Mona M Allam, Reham M Ibrahim, Walaa Bayoumie El Gazzar, Mona A Said","doi":"10.1080/13813455.2021.1975758","DOIUrl":"10.1080/13813455.2021.1975758","url":null,"abstract":"Context: Inflammatory and immune pathways play a crucial role in the pathophysiology of non-alcoholic fatty liver disease (NAFLD). Sitagliptin blocks the dipeptidyl peptidase-4 (DPP-4) enzyme, mechanisms that alter inflammatory pathways and the innate immune system, and by which Sitagliptin affects the pathogenesis of NAFLD weren't previously discussed.Objective: This study aims to understand the interaction between Sitagliptin and innate immune response in order to meliorate NAFLD.Methods: Thirty- two Wistar male albino rats were categorised into four groups. Rats have received a standard diet or a high-fat diet either with or without Sitagliptin. Serum HMGB1, protein and mRNA expressions of hepatic TLR4 and NF-κB, inflammatory cytokines, and histopathological changes were analysed.Results: An ameliorative action of Sitagliptin in NAFLD was demonstrated via decreasing HMGB1-mediated TLR4/NF-κB signalling in order to suppress inflammation and reduce insulin resistance.Conclusion: Sitagliptin may in fact prove to be a beneficial therapeutic intervention in NAFLD.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"87-95"},"PeriodicalIF":3.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39434162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of erythropoietin and myoinositol versus metformin on insulin resistance in a rat model of polycystic ovary syndrome. 红细胞生成素和肌醇与二甲双胍对多囊卵巢综合征大鼠模型中胰岛素抵抗的影响

IF 3 4区医学

Archives of Physiology and Biochemistry Pub Date : 2024-02-01 Epub Date: 2021-07-23 DOI: 10.1080/13813455.2021.1949023

Amany Abdelrahman, Aida Abdeen Mahmoud, Youstina Lamie Fanous, Nesreen Gamal Abd Elhaliem, Hassan Elalaf

引用次数: 0

Chemical characterisation and appraisal of antidiabetic potential of Terminalia citrina extract in streptozotocin induced hyperglycaemia in Wistar rats. 枸橘萃取物在链脲佐菌素诱导的 Wistar 大鼠高血糖症中的化学特性和抗糖尿病潜力评估

IF 3 4区医学

Archives of Physiology and Biochemistry Pub Date : 2024-02-01 Epub Date: 2021-08-17 DOI: 10.1080/13813455.2021.1963783

Ammara Saleem, Muhammad Furqan Akhtar, Ayesha Latif, Mohamed M Abdel-Daim, Mirza Muhammad Faran Ashraf Baig, Mohammad Saleem, Malik Hassan Mehmood

{"title":"Chemical characterisation and appraisal of antidiabetic potential of Terminalia citrina extract in streptozotocin induced hyperglycaemia in Wistar rats.","authors":"Ammara Saleem, Muhammad Furqan Akhtar, Ayesha Latif, Mohamed M Abdel-Daim, Mirza Muhammad Faran Ashraf Baig, Mohammad Saleem, Malik Hassan Mehmood","doi":"10.1080/13813455.2021.1963783","DOIUrl":"10.1080/13813455.2021.1963783","url":null,"abstract":"The current research was aimed to evaluate the antidiabetic activity of Terminalia citrina methanolic extract (TCME) by streptozotocin-induced diabetes in male Wistar rats. TCME exhibited better in-vitro antioxidant and alpha-amylase inhibitory activity as compared to other tested extracts. TCME at 250, 500, and 750 mg/kg showed notable (p < .05) antidiabetic potential by lowering fasting blood glucose level, restoring lipid level, serum amylase, HbA1c, kidney, and liver function tests as coevidenced from histological findings of the liver, pancreas, and kidney. TCME remarkably reinstated the antioxidant enzymatic activities (CAT: 0.181 ± 0.011 IU/mg protein, SOD: 21.45 ± 1.53 IU/mg protein) and reduced lipid peroxidation level (40.60 ± 2.41 µM/mg protein) in the liver and kidney tissue of diabetic rats at 750 mg/kg dose. The acute and subacute oral toxicity study of TCME exhibited no clinical toxicity signs and mortality. Its GC-MS spectrum unveiled the existence of 10-octadecenoic acid and other compounds which might have contributed to antidiabetic potential.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"56-69"},"PeriodicalIF":3.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39319740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

H₂S-mediated blockage of protein acetylation and oxidative stress attenuates lipid overload-induced cardiac senescence. H2S 介导的蛋白质乙酰化和氧化应激阻断可减轻脂质超载诱导的心脏衰老。

IF 3 4区医学

Archives of Physiology and Biochemistry Pub Date : 2024-02-01 Epub Date: 2021-09-11 DOI: 10.1080/13813455.2021.1976209

Ruihuan Yu, Yuehong Wang, Jiechun Zhu, Guangdong Yang

{"title":"H2S-mediated blockage of protein acetylation and oxidative stress attenuates lipid overload-induced cardiac senescence.","authors":"Ruihuan Yu, Yuehong Wang, Jiechun Zhu, Guangdong Yang","doi":"10.1080/13813455.2021.1976209","DOIUrl":"10.1080/13813455.2021.1976209","url":null,"abstract":"Hydrogen sulphide (H2S), a newly identified gasotransmitter, can be endogenously produced by cystathionine gamma-lyase (CSE) in the cardiovascular system. This study investigated the role of the CSE/H2S system on lipid overload-induced lipotoxicity and cardiac senescence. Lipid overload in rat cardiomyocyte cells (H9C2) promoted intracellular accumulation of lipid, oxidative stress, mitochondrial dysfunctions, lipid peroxidation and inhibited cell viability, all of which could be reversed by exogenously applied H2S. Further data revealed that H2S protected H9C2 cells from lipid overload-induced senescence by altering the expressions of lipid metabolism-related genes and inhibiting cellular acetyl-CoA and global protein acetylation. Enhancement of protein acetylation abolished the protective role of H2S on cardiac senescence. In vivo, knockout of the CSE gene strengthened cardiac lipid accumulation, protein acetylation, and cellular ageing in high fat diet-fed mice. Taken together, the CSE/H2S system is capable of maintaining lipid homeostasis and cellular senescence in heart cells under lipid overload.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"96-109"},"PeriodicalIF":3.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39426433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacological benefits of Acacia against metabolic diseases: intestinal-level bioactivities and favorable modulation of gut microbiota. 金合欢对代谢性疾病的药理作用：肠道级生物活性和肠道微生物群的有利调节。

IF 3 4区医学

Archives of Physiology and Biochemistry Pub Date : 2024-02-01 Epub Date: 2021-08-19 DOI: 10.1080/13813455.2021.1966475

Manas Ranjan Saha, Priyankar Dey

{"title":"Pharmacological benefits of Acacia against metabolic diseases: intestinal-level bioactivities and favorable modulation of gut microbiota.","authors":"Manas Ranjan Saha, Priyankar Dey","doi":"10.1080/13813455.2021.1966475","DOIUrl":"10.1080/13813455.2021.1966475","url":null,"abstract":"Context: Obesity-associated chronic metabolic disease is a leading contributor to mortality globally. Plants belonging to the genera Acacia are routinely used for the treatment of diverse metabolic diseases under different ethnomedicinal practices around the globe.Objective: The current review centres around the pharmacological evidence of intestinal-level mechanisms for metabolic health benefits by Acacia spp.Results: Acacia spp. increase the proportions of gut commensals (Bifidobacterium and Lactobacillus) and reduces the population of opportunistic pathobionts (Escherichia coli and Clostridium). Acacia gum that is rich in fibre, can also be a source of prebiotics to improve gut health. The intestinal-level anti-inflammatory activities of Acacia are likely to contribute to improvements in gut barrier function that would prevent gut-to-systemic endotoxin translocation and limit \"low-grade\" inflammation associated with metabolic diseases.Conclusion: This comprehensive review for the first time has emphasised the intestinal-level benefits of Acacia spp. which could be instrumental in limiting the burden of metabolic disease.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"70-86"},"PeriodicalIF":3.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39326061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abrogation of cardiomyopathy in diabetic rats by escin - possible role of NF-κβ and MCP-1. 埃斯京能减轻糖尿病大鼠的心肌病 - NF-κβ 和 MCP-1 的可能作用

IF 3 4区医学

Archives of Physiology and Biochemistry Pub Date : 2024-02-01 Epub Date: 2021-08-12 DOI: 10.1080/13813455.2021.1963782

Sachin V Suryavanshi, Yogesh A Kulkarni

{"title":"Abrogation of cardiomyopathy in diabetic rats by escin - possible role of NF-κβ and MCP-1.","authors":"Sachin V Suryavanshi, Yogesh A Kulkarni","doi":"10.1080/13813455.2021.1963782","DOIUrl":"10.1080/13813455.2021.1963782","url":null,"abstract":"Objective: Diabetic cardiomyopathy is one of the most common complications of diabetes. Escin may significantly inhibit myocardial damage through its NF-κβ inhibitory, antidiabetic, neuroprotective, and potent anti-inflammatory activity. Hence, the study was carried out to evaluate the effect of escin in diabetic cardiomyopathy.Methods: Diabetes induction was done in rats with streptozotocin. After six weeks of induction, diabetic animals were administered with escin (5, 10, and 20 mg/kg) for the next four weeks.Results: Escin prevented the progression of abnormalities in the biochemical, hemodynamic parameters and electrocardiogram. Escin also prevented the progression of abnormality in the oxidative stress parameters. The expression of NF-κβ and MCP-1 was significantly reduced with escin treatment. Furthermore, escin also prevented damage to myocardial cells and reduced collagen deposition in the cardiomyocytes.Conclusion: Escin prevented the progression of cardiomyopathy in diabetic rats. Hence escin can be an alternative option for the management of diabetic cardiomyopathy.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"49-55"},"PeriodicalIF":3.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39314895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hepatoprotection of capsaicin in alcoholic and non-alcoholic fatty liver diseases. 辣椒素对酒精性和非酒精性脂肪肝的护肝作用

IF 3 4区医学

Archives of Physiology and Biochemistry Pub Date : 2024-02-01 Epub Date: 2021-08-16 DOI: 10.1080/13813455.2021.1962913

Elham Karimi-Sales, Gisou Mohaddes, Mohammad Reza Alipour

引用次数: 0

The triggering pathway, the metabolic amplifying pathway, and cellular transduction in regulation of glucose-dependent biphasic insulin secretion. 调节葡萄糖依赖性双相胰岛素分泌的触发途径、代谢放大途径和细胞传导。

IF 3 4区医学

Archives of Physiology and Biochemistry Pub Date : 2024-01-09 DOI: 10.1080/13813455.2023.2299920

Shradha Bisht, Mamta F Singh

{"title":"The triggering pathway, the metabolic amplifying pathway, and cellular transduction in regulation of glucose-dependent biphasic insulin secretion.","authors":"Shradha Bisht, Mamta F Singh","doi":"10.1080/13813455.2023.2299920","DOIUrl":"https://doi.org/10.1080/13813455.2023.2299920","url":null,"abstract":"Introduction: Insulin secretion is a highly regulated process critical for maintaining glucose homeostasis. This abstract explores the intricate interplay between three essential pathways: The Triggering Pathway, The Metabolic Amplifying Pathway, and Cellular Transduction, in orchestrating glucose-dependent biphasic insulin secretion.Mechanism: During the triggering pathway, glucose metabolism in pancreatic beta-cells leads to ATP production, closing ATP-sensitive potassium channels and initiating insulin exocytosis. The metabolic amplifying pathway enhances insulin secretion via key metabolites like NADH and glutamate, enhancing calcium influx and insulin granule exocytosis. Additionally, the cellular transduction pathway involves G-protein coupled receptors and cyclic AMP, modulating insulin secretion.Result and Conclusion: These interconnected pathways ensure a dynamic insulin response to fluctuating glucose levels, with the initial rapid phase and the subsequent sustained phase. Understanding these pathways' complexities provides crucial insights into insulin dysregulation in diabetes and highlights potential therapeutic targets to restore glucose-dependent insulin secretion.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-12"},"PeriodicalIF":3.0,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139401617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tomatidine ameliorates high-fat-diet/streptozocin (HFD/STZ)-induced type 2 diabetes mellitus in mice. 托马替丁能改善高脂饮食/链脲佐菌素（HFD/STZ）诱导的小鼠 2 型糖尿病。

IF 3 4区医学

Archives of Physiology and Biochemistry Pub Date : 2024-01-08 DOI: 10.1080/13813455.2023.2298404

Li Cai, Baojian Hou, Juping Hu

{"title":"Tomatidine ameliorates high-fat-diet/streptozocin (HFD/STZ)-induced type 2 diabetes mellitus in mice.","authors":"Li Cai, Baojian Hou, Juping Hu","doi":"10.1080/13813455.2023.2298404","DOIUrl":"https://doi.org/10.1080/13813455.2023.2298404","url":null,"abstract":"Objective: To investigate the effects of tomatidine (Td) on the progression of type 2 diabetes mellitus (T2DM) in mice and uncover the mechanism.Methods: T2DM mice model was induced by high-fat diet (HFD) and intrabitoneal injection of streptozotocin (STZ). The mice were grouped as follows: 1, control; 2, T2D; 3, T2D + tomatidine (5 mg/kg); 4, T2D + tomatidine (10 mg/kg); 5, T2D + tomatidine (20 mg/kg). Fasting blood glucose was detected by glucose metre and fasting insulin was detected by the kit to determine the effect of Td on T2DM mice. ELISA, qPCR, and Immunoblot assays were performed to detect the effects of Td on the hepatic glucose homeostasis and inflammation of mice. Immunoblot assays further confirmed the mechanism.Results: Td improved blood glucose and insulin resistance in T2DM mice. In addition, Td improved liver function and lipid metabolism disorder in T2DM mice. Td also affected the liver glucose homeostasis related genes in T2DM mice. Td alleviated serum inflammation in T2DM mice. We further found that Td activated AMPK pathway, therefore ameliorating T2DM.Conclusion: Td ameliorated HFD/STZ-induced T2DM in mice, suggesting that it could serve as a drug of T2DM.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-6"},"PeriodicalIF":3.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139377147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The oral microbial odyssey influencing chronic metabolic disease. 影响慢性代谢性疾病的口腔微生物奥德赛。

IF 3 4区医学

Archives of Physiology and Biochemistry Pub Date : 2023-12-25 DOI: 10.1080/13813455.2023.2296346

Upasana Gupta, Priyankar Dey

{"title":"The oral microbial odyssey influencing chronic metabolic disease.","authors":"Upasana Gupta, Priyankar Dey","doi":"10.1080/13813455.2023.2296346","DOIUrl":"https://doi.org/10.1080/13813455.2023.2296346","url":null,"abstract":"Introduction: Since the oral cavity is the gateway to the gut, oral microbes likely hold the potential to influence metabolic disease by affecting the gut microbiota.Method: A thorough review of literature has been performed to link the alterations in oral microbiota with chronic metabolic disease by influencing the gut microbiota.Result: A strong correlation exists between abnormalities in oral microbiota and several systemic disorders, such as cardiovascular disease, diabetes, and obesity, which likely initially manifest as oral diseases. Ensuring adequate oral hygiene practices and cultivating diverse oral microflora are crucial for the preservation of general well-being. Oral bacteria have the ability to establish and endure in the gastrointestinal tract, leading to the development of prolonged inflammation and activation of the immune system. Oral microbe-associated prophylactic strategies could be beneficial in mitigating metabolic diseases.Conclusion: Oral microbiota can have a profound impact on the gut microbiota and influence the pathogenesis of metabolic diseases.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-17"},"PeriodicalIF":3.0,"publicationDate":"2023-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139032120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0