Archives of Physiology and Biochemistry最新文献_第8页

Neem seed protein hydrolysates alleviate iron-induced cardiac injury via effects on angiotensin-converting enzyme, purinergic enzymes, redox balance, and lipid metabolism. 印度楝籽蛋白水解物通过影响血管紧张素转换酶、嘌呤能酶、氧化还原平衡和脂质代谢来减轻铁诱导的心脏损伤。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-03-28 DOI: 10.1080/13813455.2025.2483912

Marvellous A Acho, Ochuko L Erukainure, Veronica F Salau, Osarenkhoe O Osemwegie, Eric Amonsou, Rotimi O Arise

{"title":"Neem seed protein hydrolysates alleviate iron-induced cardiac injury via effects on angiotensin-converting enzyme, purinergic enzymes, redox balance, and lipid metabolism.","authors":"Marvellous A Acho, Ochuko L Erukainure, Veronica F Salau, Osarenkhoe O Osemwegie, Eric Amonsou, Rotimi O Arise","doi":"10.1080/13813455.2025.2483912","DOIUrl":"https://doi.org/10.1080/13813455.2025.2483912","url":null,"abstract":"This study assessed the cardioprotective effects of <1 kDa peptide fractions from neem seed protein hydrolysates (NSPHs) in cardiac tissues ex vivo. Oxidative injury was induced in cardiac tissues from male Wister rats by incubating with 0.1 mM FeSO4 (pro-oxidant) for 30 minutes. Untreated tissues lacked peptide fractions, while normal control tissues lacked peptide and pro-oxidant. Treatment with the peptides increased the activities/levels of catalase, superoxide dismutase, ENTPDase, 5'NTPDase, glutathione, and HDL-cholesterol. Conversely, the levels/activities of malondialdehyde, nitric oxide, cholesterol, LDL-cholesterol, ACE, acetylcholinesterase, ATPase decreased following treatment with NSPH peptide fractions. Furthermore, the peptides depleted oxidative metabolites, while concomitantly inactivating plasmalogen synthesis and beta-oxidation of long-chain saturated fatty acids. These findings suggest that <1 kDa peptide fractions from neem seed protein hydrolysates have cardioprotective properties, potentially offering a natural therapeutic option for managing oxidative cardiac dysfunction through the regulation of oxidative stress, cholinesterase and purinergic activities, and lipid metabolism.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-13"},"PeriodicalIF":2.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-atherogenic properties of Plectranthus glandulosus Hook. F. (Lamiaceae) leaves through lipid profile regulation, oxidative stress reduction, and aorta media thickening attenuation in high-fat diet-fed Sprague-Dawley rats. Plectranthus glandulosus Hook.F.（唇形科）叶片通过调节高脂饮食喂养的 Sprague-Dawley 大鼠的血脂状况、减少氧化应激和减轻主动脉介质增厚的作用。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-03-14 DOI: 10.1080/13813455.2025.2476644

Djamila Zouheira, Anu Kajal, Moïse Legentil Nchouwet, Sylviane Laure Poualeu Kamani, Lauve Rachel Tchokouaha Yamthe, Gabriel Agbor Agbor, Sylvie Lea Wansi Ngnokam, Randhir Singh

{"title":"Anti-atherogenic properties of Plectranthus glandulosus Hook. F. (Lamiaceae) leaves through lipid profile regulation, oxidative stress reduction, and aorta media thickening attenuation in high-fat diet-fed Sprague-Dawley rats.","authors":"Djamila Zouheira, Anu Kajal, Moïse Legentil Nchouwet, Sylviane Laure Poualeu Kamani, Lauve Rachel Tchokouaha Yamthe, Gabriel Agbor Agbor, Sylvie Lea Wansi Ngnokam, Randhir Singh","doi":"10.1080/13813455.2025.2476644","DOIUrl":"https://doi.org/10.1080/13813455.2025.2476644","url":null,"abstract":"This study investigated the anti-atherogenic effects of Plectranthus glandulosus leaves aqueous, hydro-ethanolic extracts, and ethyl acetate fraction at doses of 100, 200, and 400 mg/kg for 21 d. As results, at the dose of 400 mg/kg, the ethyl acetate fraction significantly (p < .001) decreased the level of total cholesterol (112.52 ± 1.21 mg/dL), triglyceride (76.47 ± 0.97 mg/dL), and LDL-C (22.01 ± 2.92 mg/dL). Whereas, a significant (p < .001) increase was observed in the level of HDL-C (74.97 ± 1.99 mg/dL). Moreover, the atherogenic index significantly (p < .001) decreased (0.008 ± 0.00 mg/dL), while the percentage of atherogenic protection increased (99.13 ± 0.78%). The activity of antioxidant enzymes increased significantly (p < .001), while malondialdehyde concentration decreased. The thickening of aorta media (67.27 ± 7.15 µm) was also attenuated significantly (p < .001). Thus, our finding supports the use of Plectranthus glandulosus for future atherosclerosis drug discovery.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-15"},"PeriodicalIF":2.5,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143622990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular mechanism of METTL3 regulating hippocampal neuronal injury induced by sepsis-associated encephalopathy. METTL3调节败血症相关脑病海马神经元损伤的分子机制。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-03-02 DOI: 10.1080/13813455.2025.2465337

Qian Zhang, Yan Huo, Runying Zhu, Xujie Zhang, Lingwei Zeng, Zhenjie Hu

{"title":"Molecular mechanism of METTL3 regulating hippocampal neuronal injury induced by sepsis-associated encephalopathy.","authors":"Qian Zhang, Yan Huo, Runying Zhu, Xujie Zhang, Lingwei Zeng, Zhenjie Hu","doi":"10.1080/13813455.2025.2465337","DOIUrl":"https://doi.org/10.1080/13813455.2025.2465337","url":null,"abstract":"Objective: This study explores the mechanism of methyltransferase like 3 (METTL3) on sepsis-associated encephalopathy (SAE)-induced hippocampal neuronal injury.Methods: A murine model of SAE was established by caecal ligation and puncture. Hippocampal cells were induced by lipopolysaccharide (LPS). The mouse survival was observed and behavioural tests evaluated cognitive function. METTL3 and glutamic-oxaloacetic transaminase 1 (GOT1) expressions were detected via RT-qPCR and Western blot. Immunofluorescence staining examined the co-localization of NeuN and METTL3. The m6A enrichment on GOT1 was determined by MeRIP.Results: METTL3 and GOT1 were highly expressed in SAE mice and LPS-stimulated hippocampal cells. SAE mice exhibited cognitive function impairment, reduced survival rate, and decreased neuronal cells. LPS induction increased hippocampal cell apoptosis and enhanced inflammation. Silence of METTL3 reduced hippocampal neuronal injury in SAE mice and LPS-induced hippocampal cell injury.Conclusion: METTL3-mediated m6A modification on GOT1 mRNA elevates GOT1 expression, thereby aggravating SAE-induced hippocampal neuronal injury.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-11"},"PeriodicalIF":2.5,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bee bread shows therapeutic and protective effects by alleviating inflammation, oxidative stress, and apoptosis on acetic acid-induced gastric ulcer in rats. 蜜蜂面包对醋酸诱发的大鼠胃溃疡具有治疗和保护作用，能减轻炎症、氧化应激和细胞凋亡。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-02-23 DOI: 10.1080/13813455.2025.2466191

Hatice Colak, Esra Tansu Sarıyer, Meral Yüksel, İlayda Özge Polat, Esra Çikler, Neslihan Öner, Berna Karakoyun

{"title":"Bee bread shows therapeutic and protective effects by alleviating inflammation, oxidative stress, and apoptosis on acetic acid-induced gastric ulcer in rats.","authors":"Hatice Colak, Esra Tansu Sarıyer, Meral Yüksel, İlayda Özge Polat, Esra Çikler, Neslihan Öner, Berna Karakoyun","doi":"10.1080/13813455.2025.2466191","DOIUrl":"https://doi.org/10.1080/13813455.2025.2466191","url":null,"abstract":"Objective: This study investigated bee bread's (BB) protective and therapeutic effects on acetic acid-(AA)-induced gastric ulcers via oxidative stress, DNA damage, inflammation, and apoptosis.Materials and methods: Rats were administered saline-(1ml) or BB-(0.5g/kg/day;1ml) by oral gavage once daily for 10-day following 80% AA-induced chronic ulceration in treatment group. Pretreatment group received saline or BB for 10-day before and 3-day after ulcer induction. Stomachs of decapitated rats were collected for ulcer index, histological and biochemical analyses.Results: BB significantly reduced the gastric ulcer index and levels of chemiluminescence, HMGB-1, IL-6, IL-1ß and IL-8 levels in pretreatment and treatment groups. In BB-pretreated ulcer group, MPO-(salineBB, 39.9±3.7 U/g;22.2±2.2 U/g), caspase-3 (0.40±0.07 ng/g;0.18±0.01 ng/g) and IFN-γ (15.46±1.76;9.51±1.95 ng/g) levels decreased and TNF-α (31.77±5.13;18.94±2.59 ng/g) reduced only in BB-treated ulcer group. MDA, GSH, NRF-2, and 8-OHdG levels remained unchanged.Conclusion: BB has demonstrated protective and therapeutic effects by reducing ROS production, modulating inflammation and apoptosis.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-11"},"PeriodicalIF":2.5,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of cinnamon and statins drug on kidney and liver of rats receiving gentamicin. 肉桂和他汀类药物对庆大霉素大鼠肾脏和肝脏的影响。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-02-20 DOI: 10.1080/13813455.2025.2465335

Abdulrahim Aljamal, Mahmoud Al Shawabkeh, Taha Alqadi

引用次数: 0

Prediction of maximum voluntary ventilation based on forced expiratory volume in athletes. 基于运动员用力呼气量的最大自主通气预测。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-02-17 DOI: 10.1080/13813455.2025.2465333

Irma Lorenzo-Capellá, Juan José Ramos-Álvarez, Elena Jiménez-Herranz, Nicola Maffulli, Enzo Iuliano, Johnny Padulo, Francisco Javier Calderón-Montero

{"title":"Prediction of maximum voluntary ventilation based on forced expiratory volume in athletes.","authors":"Irma Lorenzo-Capellá, Juan José Ramos-Álvarez, Elena Jiménez-Herranz, Nicola Maffulli, Enzo Iuliano, Johnny Padulo, Francisco Javier Calderón-Montero","doi":"10.1080/13813455.2025.2465333","DOIUrl":"10.1080/13813455.2025.2465333","url":null,"abstract":"Objective: Maximum-voluntary-ventilation (MVV) is the maximal volume of which an individual can move by voluntary effort in one minute. It is possible that the first second forced-expiratory-volume (FEV1) could be more to reliable assess respiratory muscle endurance to estimate MVV.Methods: For this aim, 422 athletes (Age 22.9 ± 8.5 years; 98/324 - females/males) were performed a MVV, and FEV1 measurements.Results: The coefficient of determination was R2 = 0.594 between MVV and FEV1, with a predictive equation for overall participants: MVV = (FEV1 × 33.5)+12.7. The robust regression showed a good multiple correlation coefficient (R = 0.815) with the coefficient of determination R2 = 0.661 for the model including FEV1, age and gender as predictors. These equations MVV = (FEV1 X 27.3)+(Age(y) × 1.1)+20.5 and MVV = (FEV1 × 27.3)+(Age(y) × 1.1) were derived for male and female, respectively.Conclusion: FEV1 can predict MVV in different athletes with greater accuracy when stratified per gender. Therefore, this new approach can be used in a short all-out test without stress of the respiratory muscle to predict MVV in athletes.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-10"},"PeriodicalIF":2.5,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic variability of the MTHFR rs1801133 gene polymorphism and role of zinc level in obese patients. 肥胖患者MTHFR rs1801133基因多态性的遗传变异性及锌水平的作用

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-02-14 DOI: 10.1080/13813455.2025.2465338

Haider Ali Alnaji, Alkarar K Abduljaleel, Taif Al-Saadi, Abbas F Almulla

引用次数: 0

Role of berberine in metabolic and bone changes in ovariectomized rats. 小檗碱在去卵巢大鼠代谢和骨变化中的作用。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-02-13 DOI: 10.1080/13813455.2025.2465360

Yasmin Mohammed Eid, Salma Elwy Nassar, Romaysaa Ali El Sherbeny, Ramez Abd-Elmoneim Barhoma

{"title":"Role of berberine in metabolic and bone changes in ovariectomized rats.","authors":"Yasmin Mohammed Eid, Salma Elwy Nassar, Romaysaa Ali El Sherbeny, Ramez Abd-Elmoneim Barhoma","doi":"10.1080/13813455.2025.2465360","DOIUrl":"https://doi.org/10.1080/13813455.2025.2465360","url":null,"abstract":"Background: This study investigates Berberine's (BBR) impact on metabolic and bone changes in ovariectomized rats, a model for postmenopausal conditions.Methods: Sixty adult female rats divided into six groups: control, sham ovariectomized, ovariectomized, and three BBR treated ovariectomized groups (50, 100, and 200 mg/kg/day, for eight weeks). Measurements included serum oestradiol, glucose, HOMA-IR, lipid profile , tumour necrosis factor alpha (TNF-α), oxidative stress markers , osteocalcin (OC), bone-specific alkaline phosphatase (ALP), cross-linked Carboxy-terminal telopeptide of type I collagen (CTX-I), and bone tissue analysis.Results: Ovariectomized rats exhibited significant metabolic and bone deterioration, such as increased glucose, insulin, HOMA IR, total cholestrol (TC), LDL-C, TNF-α, OC, ALP, CTX-I, and MDA levels, alongside decreased oestradiol, HDL-C, and GSH levels, and DNA fragmentation (P < 0.001). BBR treatment showed dose-dependent improvements in all parameters.Conclusion: BBR demonstrates significant ameliorative effects on metabolic and bone health in ovariectomized rats, highlighting its potential therapeutic benefits for postmenopausal conditions.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-9"},"PeriodicalIF":2.5,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cilostazol attenuates mirabegron-induced hepatic and renal toxicity in rats: regulation of metabolic, oxidative, and inflammatory pathways. 西洛他唑减轻米拉贝琼诱导的大鼠肝肾毒性：调节代谢、氧化和炎症途径

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-02-01 Epub Date: 2024-08-07 DOI: 10.1080/13813455.2024.2387700

Mai M Anwar, Ibrahim M Ibrahim Laila

{"title":"Cilostazol attenuates mirabegron-induced hepatic and renal toxicity in rats: regulation of metabolic, oxidative, and inflammatory pathways.","authors":"Mai M Anwar, Ibrahim M Ibrahim Laila","doi":"10.1080/13813455.2024.2387700","DOIUrl":"10.1080/13813455.2024.2387700","url":null,"abstract":"Background: Mirabegron (MIRG) is a type of β3 adrenoceptor agonist that is considered an alternative therapy for the treatment of overactive bladder (OAB) symptoms. Cilostazol (CITZ) is a selective inhibitor of phosphodiesterase (III) that has various pharmacological effects.Objectve: The current study aimed to highlight the regulatory effects of CITZ on MIRG-induced toxicity.Materials and methods: Male rats were divided into six groups. Blood samples were collected to determine different hepatic and kidney function levels along with serum protein electrophoresis and inflammatory factor levels. Histopathological studies and oxidative stress (OS) were also assessed. Kidney and hepatic damage were detected following the administration of MIRG, especially at high doses, due to elevated OS, inflammation, and apoptotic marker levels.Results: Rats receiving CITZ exhibited significant improvements in both hepatic and kidney functions, with decreased inflammation and OS.Conclusion: CITZ administration plays a beneficial role in alleviating hepatic and nephrotoxicity induced by MIRG by inhibiting OS and inflammation.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"81-93"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141896628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of the therapeutic effect of melatonin on deltamethrin applied mouse primary hepatocyte culture. 研究褪黑素对使用溴氰菊酯的小鼠原代肝细胞培养的治疗效果。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-02-01 Epub Date: 2024-08-05 DOI: 10.1080/13813455.2024.2387696

Elif Kaval Oğuz, Ahmet Regaib Oğuz, Necati Özok, Zehra Alkan, Burcu Ergöz Azizoğlu, Elif Örgi, Ayşe Nur Erdemir, Ayşe Yeşilbaş

{"title":"Investigation of the therapeutic effect of melatonin on deltamethrin applied mouse primary hepatocyte culture.","authors":"Elif Kaval Oğuz, Ahmet Regaib Oğuz, Necati Özok, Zehra Alkan, Burcu Ergöz Azizoğlu, Elif Örgi, Ayşe Nur Erdemir, Ayşe Yeşilbaş","doi":"10.1080/13813455.2024.2387696","DOIUrl":"10.1080/13813455.2024.2387696","url":null,"abstract":"Objective: In recent years, it has been known that the melatonin hormone, secreted from the pineal gland, possesses significant antioxidant activity. This study explores the therapeutic effect of melatonin on the deleterious effects of deltamethrin, a pyrethroid pesticide extensively used worldwide, including in Türkiye, on mouse liver cells.Methods: Hepatocytes from Balb/C mice were isolated using a two-stage perfusion method, resulting in over 85% live hepatocytes. The isolated cells were cultured with different doses of deltamethrin (1 and 10 µM) and melatonin (100 µM) for 24 and 48 hours. At the conclusion of the culture period, hepatocytes were extracted at the 24th and 48th hours, and Malondialdehyde (MDA), Total Antioxidant Capacity (TAC), Total Oxidation Status (TOS), and DNA damages (8-hydroxy-2'-deoxyguanosine (8-OHdG)) were examined.Results: While an increase in MDA, TOS, and DNA damage was observed in the deltamethrin-administered groups of hepatocytes, a decrease in TAC level was noted. It was determined that the applied deltamethrin had no effect on cell viability throughout the application period.Conclusion: Furthermore, it was observed that melatonin, when administered concurrently with deltamethrin, reduced the toxic effect of deltamethrin. This study suggests that melatonin has a protective effect against deltamethrin-induced damage in mouse hepatocyte cells.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"63-70"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0