雄性瑞士小鼠在热量限制条件下进行阻力训练后,灌注肝脏中的葡萄糖代谢并没有得到改善。

IF 2.5 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Julio Ernesto Perego Junior, Kauane Tomazi Silva, Ana Luiza Balani Rando, Mateus Sousa Lima, Rosângela Fernandes Garcia, Maria Montserrat Diaz Pedrosa
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引用次数: 0

摘要

背景:能量平衡是哺乳动物生存的首要因素。许多组织和器官(其中包括肝脏)在各种情况下都能保持能量平衡,包括热量限制(CR)和体力活动:本研究使用以下几组八周大的雄性瑞士小鼠研究葡萄糖代谢:结果:各组小鼠的器官和脂肪储层均有不同程度的变化:结果:RS组和RT组的器官和脂肪库与CS组相似,但体重较低。CR不影响训练成绩,也不影响全身或肝脏葡萄糖代谢。结合 CR 进行的训练(RT 组)改善了体内葡萄糖耐量,并且不影响肝糖生成:结论:小鼠能够耐受长时间的中度 CR,其健康状况、糖稳态和阻力训练表现均未受到影响。结论:小鼠耐受了较长时间的中度 CR,其健康状况、血糖稳态和阻力训练表现均未受到影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Glucose metabolism in the perfused liver did not improve with resistance training in male Swiss mice under caloric restriction.

Context: Energy homeostasis is a primary factor for the survival of mammals. Many tissues and organs, among which is the liver, keep this homeostasis in varied circumstances, including caloric restriction (CR) and physical activity.

Objective: This study investigated glucose metabolism using the following groups of eight-week-old male Swiss mice: CS, sedentary and fed freely; RS, sedentary and RT, trained, both under 30% CR (n = 20-23 per group).

Results: Organs and fat depots of groups RS and RT were similar to CS, although body weight was lower. CR did not impair training performance nor affected systemic or hepatic glucose metabolism. Training combined with CR (group RT) improved in vivo glucose tolerance and did not affect liver gluconeogenesis.

Conclusions: The mice tolerated the prolonged moderate CR without impairment of their well-being, glucose homeostasis, and resistance training performance. But the higher liver gluconeogenic efficiency previously demonstrated using this training protocol in mice was not evidenced under CR.

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来源期刊
Archives of Physiology and Biochemistry
Archives of Physiology and Biochemistry ENDOCRINOLOGY & METABOLISM-PHYSIOLOGY
CiteScore
6.90
自引率
3.30%
发文量
21
期刊介绍: Archives of Physiology and Biochemistry: The Journal of Metabolic Diseases is an international peer-reviewed journal which has been relaunched to meet the increasing demand for integrated publication on molecular, biochemical and cellular aspects of metabolic diseases, as well as clinical and therapeutic strategies for their treatment. It publishes full-length original articles, rapid papers, reviews and mini-reviews on selected topics. It is the overall goal of the journal to disseminate novel approaches to an improved understanding of major metabolic disorders. The scope encompasses all topics related to the molecular and cellular pathophysiology of metabolic diseases like obesity, type 2 diabetes and the metabolic syndrome, and their associated complications. Clinical studies are considered as an integral part of the Journal and should be related to one of the following topics: -Dysregulation of hormone receptors and signal transduction -Contribution of gene variants and gene regulatory processes -Impairment of intermediary metabolism at the cellular level -Secretion and metabolism of peptides and other factors that mediate cellular crosstalk -Therapeutic strategies for managing metabolic diseases Special issues dedicated to topics in the field will be published regularly.
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