小檗碱在去卵巢大鼠代谢和骨变化中的作用。

IF 2.5 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Archives of Physiology and Biochemistry Pub Date : 2025-02-13 DOI:10.1080/13813455.2025.2465360

Yasmin Mohammed Eid, Salma Elwy Nassar, Romaysaa Ali El Sherbeny, Ramez Abd-Elmoneim Barhoma

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引用次数: 0

摘要

背景：本研究探讨了小檗碱（BBR）对去卵巢大鼠（绝经后疾病模型）代谢和骨变化的影响。方法：成年雌性大鼠60只，分为对照组、假去卵巢组、去卵巢组和去卵巢组（50、100、200 mg/kg/d，连续8周）。测量包括血清雌二醇、葡萄糖、HOMA-IR、脂质谱、肿瘤坏死因子α (TNF-α)、氧化应激标志物、骨钙素（OC）、骨特异性碱性磷酸酶（ALP）、I型胶原交联羧基末端端肽（CTX-I）和骨组织分析。结果：去卵巢大鼠表现出明显的代谢和骨骼恶化，如葡萄糖、胰岛素、HOMA - IR、总胆固醇（TC）、LDL-C、TNF-α、OC、ALP、CTX-I和MDA水平升高，同时雌二醇、HDL-C和GSH水平降低，以及DNA片段化(P)。结论：BBR对去卵巢大鼠的代谢和骨骼健康有显著的改善作用，突出了其对绝经后疾病的潜在治疗益处。

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Role of berberine in metabolic and bone changes in ovariectomized rats.

Background: This study investigates Berberine's (BBR) impact on metabolic and bone changes in ovariectomized rats, a model for postmenopausal conditions.

Methods: Sixty adult female rats divided into six groups: control, sham ovariectomized, ovariectomized, and three BBR treated ovariectomized groups (50, 100, and 200 mg/kg/day, for eight weeks). Measurements included serum oestradiol, glucose, HOMA-IR, lipid profile , tumour necrosis factor alpha (TNF-α), oxidative stress markers , osteocalcin (OC), bone-specific alkaline phosphatase (ALP), cross-linked Carboxy-terminal telopeptide of type I collagen (CTX-I), and bone tissue analysis.

Results: Ovariectomized rats exhibited significant metabolic and bone deterioration, such as increased glucose, insulin, HOMA IR, total cholestrol (TC), LDL-C, TNF-α, OC, ALP, CTX-I, and MDA levels, alongside decreased oestradiol, HDL-C, and GSH levels, and DNA fragmentation (P < 0.001). BBR treatment showed dose-dependent improvements in all parameters.

Conclusion: BBR demonstrates significant ameliorative effects on metabolic and bone health in ovariectomized rats, highlighting its potential therapeutic benefits for postmenopausal conditions.

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来源期刊

Archives of Physiology and Biochemistry ENDOCRINOLOGY & METABOLISM-PHYSIOLOGY

CiteScore

6.90

自引率

3.30%

发文量

期刊介绍： Archives of Physiology and Biochemistry: The Journal of Metabolic Diseases is an international peer-reviewed journal which has been relaunched to meet the increasing demand for integrated publication on molecular, biochemical and cellular aspects of metabolic diseases, as well as clinical and therapeutic strategies for their treatment. It publishes full-length original articles, rapid papers, reviews and mini-reviews on selected topics. It is the overall goal of the journal to disseminate novel approaches to an improved understanding of major metabolic disorders. The scope encompasses all topics related to the molecular and cellular pathophysiology of metabolic diseases like obesity, type 2 diabetes and the metabolic syndrome, and their associated complications. Clinical studies are considered as an integral part of the Journal and should be related to one of the following topics: -Dysregulation of hormone receptors and signal transduction -Contribution of gene variants and gene regulatory processes -Impairment of intermediary metabolism at the cellular level -Secretion and metabolism of peptides and other factors that mediate cellular crosstalk -Therapeutic strategies for managing metabolic diseases Special issues dedicated to topics in the field will be published regularly.