Effect of cinnamon and statins drug on kidney and liver of rats receiving gentamicin.

IF 2.5 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Archives of Physiology and Biochemistry Pub Date : 2025-02-20 DOI:10.1080/13813455.2025.2465335

Abdulrahim Aljamal, Mahmoud Al Shawabkeh, Taha Alqadi

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引用次数: 0

Abstract

The aim of this study is to examine the effects of cinnamon and statins on the renal and liver functions of gentamicin-received rats.

Methods: Forty male albino rats were recruited into 4 groups (10 rat each) for a 21-day period by gavage treatment. The control group 1 was given nothing but 0.5 ml normal saline, and others injected with a dose of 100 mg/kg of Gentamicin intraperitoneally for one week before treatment. Group 2 received Gentamicin alone, Group 3 received an aqueous extract of cinnamon, and Group 4 treated with a statin medication.

Results: Gentamicin-treated group compared to other groups showed a significant increase in lever and kidney enzymes. The group treated with cinnamon or statin revealed noticeable positive effects on these markers, whereas statin showed decrease in Alanine Aminotransferase ALT levels.

Conclusion: Parameters of hepatotoxicity and nephrotoxicity induced by gentamicin were significantly reserved by cinnamon or statin, statin less effective.

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来源期刊

Archives of Physiology and Biochemistry ENDOCRINOLOGY & METABOLISM-PHYSIOLOGY

CiteScore

6.90

自引率

3.30%

发文量

期刊介绍： Archives of Physiology and Biochemistry: The Journal of Metabolic Diseases is an international peer-reviewed journal which has been relaunched to meet the increasing demand for integrated publication on molecular, biochemical and cellular aspects of metabolic diseases, as well as clinical and therapeutic strategies for their treatment. It publishes full-length original articles, rapid papers, reviews and mini-reviews on selected topics. It is the overall goal of the journal to disseminate novel approaches to an improved understanding of major metabolic disorders. The scope encompasses all topics related to the molecular and cellular pathophysiology of metabolic diseases like obesity, type 2 diabetes and the metabolic syndrome, and their associated complications. Clinical studies are considered as an integral part of the Journal and should be related to one of the following topics: -Dysregulation of hormone receptors and signal transduction -Contribution of gene variants and gene regulatory processes -Impairment of intermediary metabolism at the cellular level -Secretion and metabolism of peptides and other factors that mediate cellular crosstalk -Therapeutic strategies for managing metabolic diseases Special issues dedicated to topics in the field will be published regularly.