A herbal approach to diabetic cardiomyopathy: moringa, ginger, and garlic unveiled.

IF 2.5 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Archives of Physiology and Biochemistry Pub Date : 2025-01-31 DOI:10.1080/13813455.2025.2459871

Kaushal Shah, Manjiri Jalgaonkar, Aditi Vyas, Gaurav Doshi, Yogesh A Kulkarni, Alok D Singh, Manisha J Oza

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引用次数: 0

Abstract

Objective: Chronic inflammation contributes to myocardial complications in diabetes, marked by tissue fibrosis, necrosis, and apoptosis. Zingiber officinale, Allium sativum, and Moringa oleifera have individually demonstrated efficacy in diabetes management. In this study, it is hypothesised that a combination of these herbs in a polyherbal formulation would protect against diabetic cardiomyopathy.

Materials and methods: Diabetes was induced in male Sprague Dawley rats using strepetozotocin at a single dose of (55 mg/kg of body weight, i.p) in citrate buffer. Polyherbal formulation was administred as a treatment for 8 weeks.

Rats receiving treatment with polyherbal formulation showed decreased blood glucose, plasma creatinine, Blood Urea Nitrogen, Creatine kinase- myocardial band, lactate dehydrogenase, aspartate aminotransferase, Troponin-I, NADPH oxidase 4, and Ras-related C3 botulinum toxin substrate-1. In contrast, Superoxide dismutase, catalase, and glutathione enzyme activities were increased.

Conclusion: Thus, a polyherbal formulation containing herbs was able to attenuate the progression of diabetes mellitus and diabetic cardiomyopathy.

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目的：慢性炎症是糖尿病心肌并发症的诱因之一，表现为组织纤维化、坏死和凋亡。茜草、薤白和辣木已被证明对糖尿病有单独的疗效。在本研究中，我们假设这些草药在多草药配方中的组合将保护糖尿病心肌病：雄性 Sprague Dawley 大鼠在柠檬酸缓冲液中使用单剂量（55 毫克/千克体重，静脉注射）链脲佐菌素诱发糖尿病。接受多草药制剂治疗的大鼠血糖、血浆肌酐、血尿素氮、肌酸激酶-心肌带、乳酸脱氢酶、天冬氨酸氨基转移酶、肌钙蛋白-I、NADPH 氧化酶 4 和 Ras 相关 C3 肉毒毒素底物-1 均有所下降。相比之下，超氧化物歧化酶、过氧化氢酶和谷胱甘肽酶的活性有所增加：因此，含有草药的多草药配方能够减轻糖尿病和糖尿病心肌病的进展。

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来源期刊

Archives of Physiology and Biochemistry ENDOCRINOLOGY & METABOLISM-PHYSIOLOGY

CiteScore

6.90

自引率

3.30%

发文量

期刊介绍： Archives of Physiology and Biochemistry: The Journal of Metabolic Diseases is an international peer-reviewed journal which has been relaunched to meet the increasing demand for integrated publication on molecular, biochemical and cellular aspects of metabolic diseases, as well as clinical and therapeutic strategies for their treatment. It publishes full-length original articles, rapid papers, reviews and mini-reviews on selected topics. It is the overall goal of the journal to disseminate novel approaches to an improved understanding of major metabolic disorders. The scope encompasses all topics related to the molecular and cellular pathophysiology of metabolic diseases like obesity, type 2 diabetes and the metabolic syndrome, and their associated complications. Clinical studies are considered as an integral part of the Journal and should be related to one of the following topics: -Dysregulation of hormone receptors and signal transduction -Contribution of gene variants and gene regulatory processes -Impairment of intermediary metabolism at the cellular level -Secretion and metabolism of peptides and other factors that mediate cellular crosstalk -Therapeutic strategies for managing metabolic diseases Special issues dedicated to topics in the field will be published regularly.