Triglycerides and metabolic syndrome: from basic to mechanism - A narrative review.

IF 2.5 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Archives of Physiology and Biochemistry Pub Date : 2024-11-14 DOI:10.1080/13813455.2024.2426496

Gayathri S Prabhu, Preethi Lavina Concessao

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引用次数: 0

Abstract

Content: The impact of triglyceride levels is important to understand the changes in metabolism and structure. With an increase in obesity and hyperlipidemia due to diet; cardiovascular and neuronal structural changes have been shown to be more distinct.

Objective: This review aims to discuss the pathophysiology and mechanisms involved in increased levels of triglycerides leading to vascular impairment, metabolic syndrome and cognitive decline.

Methods: The literature search was performed using the PubMed, Google scholar and Scopus databases, among which 180 articles were shortlisted based on key words, abstract, materials and methods and results. Among these 74 articles have been cited for the review.

Results and discussion: The review discusses the impact of hypertriglyceridemia on metabolism, triglyceride storage, and neurovascular integrity, highlighting mechanisms contributing to vascular dysfunction, metabolic syndrome, and cognitive deterioration.

Conclusion: Elevated triglyceride levels are a key factor in altering metabolic pathways and structural integrity in cardiovascular and neuronal systems. This review provides insights into the mechanisms underlying metabolic disorders caused by elevated triglyceride levels, It highlights the need for further studies to provide more supportive evidence and address existing limitations in understanding these changes.

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甘油三酯与代谢综合征：从基础到机制--综述。

内容：甘油三酯水平的影响对于了解新陈代谢和结构的变化非常重要。随着饮食导致的肥胖和高脂血症的增加，心血管和神经元结构的变化已被证明更为明显：本综述旨在讨论甘油三酯水平升高导致血管损伤、代谢综合征和认知能力下降的病理生理学和相关机制：使用 PubMed、Google scholar 和 Scopus 数据库进行文献检索，根据关键词、摘要、材料和方法以及结果筛选出 180 篇文章。结果与讨论：综述讨论了高甘油三酯血症对新陈代谢、甘油三酯储存和神经血管完整性的影响，强调了导致血管功能障碍、代谢综合征和认知功能退化的机制：结论：甘油三酯水平升高是改变心血管和神经系统代谢途径和结构完整性的关键因素。本综述深入探讨了甘油三酯水平升高导致代谢紊乱的机制，强调了进一步研究的必要性，以提供更多支持性证据，并解决在理解这些变化方面存在的局限性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Physiology and Biochemistry ENDOCRINOLOGY & METABOLISM-PHYSIOLOGY

CiteScore

6.90

自引率

3.30%

发文量

期刊介绍： Archives of Physiology and Biochemistry: The Journal of Metabolic Diseases is an international peer-reviewed journal which has been relaunched to meet the increasing demand for integrated publication on molecular, biochemical and cellular aspects of metabolic diseases, as well as clinical and therapeutic strategies for their treatment. It publishes full-length original articles, rapid papers, reviews and mini-reviews on selected topics. It is the overall goal of the journal to disseminate novel approaches to an improved understanding of major metabolic disorders. The scope encompasses all topics related to the molecular and cellular pathophysiology of metabolic diseases like obesity, type 2 diabetes and the metabolic syndrome, and their associated complications. Clinical studies are considered as an integral part of the Journal and should be related to one of the following topics: -Dysregulation of hormone receptors and signal transduction -Contribution of gene variants and gene regulatory processes -Impairment of intermediary metabolism at the cellular level -Secretion and metabolism of peptides and other factors that mediate cellular crosstalk -Therapeutic strategies for managing metabolic diseases Special issues dedicated to topics in the field will be published regularly.