Archives of Physiology and Biochemistry最新文献_第5页

The effect of elevated levels of the gut metabolite TMAO on glucose metabolism after sleeve gastrectomy. 小肠代谢物TMAO水平升高对袖式胃切除术后葡萄糖代谢的影响。

IF 2.7 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-08-01 Epub Date: 2025-04-09 DOI: 10.1080/13813455.2025.2489721

Zhiping Huang, Chaoqian Liu, Xiang Zhao, Yan Guo

{"title":"The effect of elevated levels of the gut metabolite TMAO on glucose metabolism after sleeve gastrectomy.","authors":"Zhiping Huang, Chaoqian Liu, Xiang Zhao, Yan Guo","doi":"10.1080/13813455.2025.2489721","DOIUrl":"10.1080/13813455.2025.2489721","url":null,"abstract":"Purpose: Bariatric surgery can effectively alleviate obesity and diabetes by regulation of the gut microbiota. This study aimed to investigate the change in the gut microbiota metabolite TMAO and to explore its effect on glucose metabolism after sleeve gastrectomy (SG).Materials and methods: Diet-induced obesity mouse models were established, and the mice were randomly divided into four groups: an SG group, a sham-operated group pair-fed with the SG group (PF), a sham-operated group fed ad libitum (AL), and a lean control group (C). At 10 weeks post-surgery, the changes in glycogen content of liver, gut microbiota and the level of FMO3 in the liver were evaluated, and their correlation with TMAO production was analysed. The expression levels of the TMAO/PERK/FOXO1 pathway and the gluconeogenic genes G6PC and PCK1 were measured.Results: At 10 weeks post-surgery, hepatocyte glycogen levels were restored, and serum TMA and TMAO levels were significantly increased. Faecal metagenomic sequencing results showed that the abundances of Ruminococcaceae and Lachnospiraceae, which were positively correlated with TMAO production, were significantly increased after surgery. While the changes in FMO3, the key enzyme producing TMAO in the liver was found decreased significantly after SG. The expression levels of the TMAO/PERK/FOXO1 pathway and the gluconeogenic genes G6PC and PCK1 were measured. Inconsistent with the changing trend of TMAO, the expression of PERK, FOXO1, PCK, and G6PC significantly decreased after SG.Conclusions: SG can significantly reduce obesity and restore glucose metabolism. After surgery, TMAO metabolites increased in a microbiota-dependent manner.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"691-700"},"PeriodicalIF":2.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular mechanism of METTL3 regulating hippocampal neuronal injury induced by sepsis-associated encephalopathy. METTL3调节败血症相关脑病海马神经元损伤的分子机制。

IF 2.7 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-08-01 Epub Date: 2025-03-02 DOI: 10.1080/13813455.2025.2465337

Qian Zhang, Yan Huo, Runying Zhu, Xujie Zhang, Lingwei Zeng, Zhenjie Hu

{"title":"Molecular mechanism of METTL3 regulating hippocampal neuronal injury induced by sepsis-associated encephalopathy.","authors":"Qian Zhang, Yan Huo, Runying Zhu, Xujie Zhang, Lingwei Zeng, Zhenjie Hu","doi":"10.1080/13813455.2025.2465337","DOIUrl":"10.1080/13813455.2025.2465337","url":null,"abstract":"Objective: This study explores the mechanism of methyltransferase like 3 (METTL3) on sepsis-associated encephalopathy (SAE)-induced hippocampal neuronal injury.Methods: A murine model of SAE was established by caecal ligation and puncture. Hippocampal cells were induced by lipopolysaccharide (LPS). The mouse survival was observed and behavioural tests evaluated cognitive function. METTL3 and glutamic-oxaloacetic transaminase 1 (GOT1) expressions were detected via RT-qPCR and Western blot. Immunofluorescence staining examined the co-localization of NeuN and METTL3. The m6A enrichment on GOT1 was determined by MeRIP.Results: METTL3 and GOT1 were highly expressed in SAE mice and LPS-stimulated hippocampal cells. SAE mice exhibited cognitive function impairment, reduced survival rate, and decreased neuronal cells. LPS induction increased hippocampal cell apoptosis and enhanced inflammation. Silence of METTL3 reduced hippocampal neuronal injury in SAE mice and LPS-induced hippocampal cell injury.Conclusion: METTL3-mediated m6A modification on GOT1 mRNA elevates GOT1 expression, thereby aggravating SAE-induced hippocampal neuronal injury.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"582-592"},"PeriodicalIF":2.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From the gut to the heart: probiotic therapy with Saccharomyces boulardii and its potential role on diabetic cardiomyopathy in a murine model. 从肠道到心脏：博氏酵母菌的益生菌治疗及其在小鼠糖尿病心肌病模型中的潜在作用

IF 2.7 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-07-31 DOI: 10.1080/13813455.2025.2539188

Ana Beatriz P Brandão, Raquel C M F Albuquerque, Isabel C M E de Abreu, Fabiana G Ferreira, Leticia B Santos, Leonardo Jensen, Leandro Eziquiel de Souza, Sarah G Ferreira, Lívia B de Souza, Emília Lo Schiavo, Luciana Sant Anna, Elisa M Higa, Adenauer Casali, Flávio Aimbire, Maria Claudia C Irigoyen, Karina R Casali, Tatiana S Cunha

{"title":"From the gut to the heart: probiotic therapy with Saccharomyces boulardii and its potential role on diabetic cardiomyopathy in a murine model.","authors":"Ana Beatriz P Brandão, Raquel C M F Albuquerque, Isabel C M E de Abreu, Fabiana G Ferreira, Leticia B Santos, Leonardo Jensen, Leandro Eziquiel de Souza, Sarah G Ferreira, Lívia B de Souza, Emília Lo Schiavo, Luciana Sant Anna, Elisa M Higa, Adenauer Casali, Flávio Aimbire, Maria Claudia C Irigoyen, Karina R Casali, Tatiana S Cunha","doi":"10.1080/13813455.2025.2539188","DOIUrl":"https://doi.org/10.1080/13813455.2025.2539188","url":null,"abstract":"Background: We investigated whether the probiotic yeast Saccharomyces boulardii confers cardiometabolic protection and prevents diabetic cardiomyopathy by modulating inflammation, cardiac remodelling, cardiovascular function, and autonomic regulation.Methods: Male C57BL/6 mice were allocated into four groups: Control (C), Diabetes (DM), Control+Saccharomyces boulardii (CSb), and Diabetes+Saccharomyces boulardii (DMSb). Diabetes was induced with intraperitoneal streptozotocin (STZ), and treatments (sterile water or Saccharomyces boulardii) were administered orally for 8 weeks. Blood glucose, cytokines, and nitric oxide levels were measured, along with cardiac function via echocardiography and direct blood pressure recordings.Results: Saccharomyces boulardii reduced blood glucose and increased cardiac IL-10 in diabetic mice, restoring nitric oxide levels. These effects were associated to reduced collagen deposition, preventing vascular damage and ventricular fibrosis, and were accompanied by improved systolic/diastolic function and autonomic control.Conclusion: Saccharomyces boulardii improved cardiac structure, function, and autonomic control in diabetic mice, supporting its potential as adjunct therapy for diabetic cardiomyopathy.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-14"},"PeriodicalIF":2.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A hybrid M-DbneAlexnet for brain tumour detection using MRI images. 混合M-DbneAlexnet用于脑肿瘤的MRI图像检测。

IF 2.7 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-07-29 DOI: 10.1080/13813455.2025.2531118

Jayasri Kotti, Vidyadhari Chalasani, Creesy Rajan

{"title":"A hybrid M-DbneAlexnet for brain tumour detection using MRI images.","authors":"Jayasri Kotti, Vidyadhari Chalasani, Creesy Rajan","doi":"10.1080/13813455.2025.2531118","DOIUrl":"https://doi.org/10.1080/13813455.2025.2531118","url":null,"abstract":"Introduction: Brain Tumour (BT) is characterised by the uncontrolled proliferation of the cells within the brain which can result in cancer. Detecting BT at the early stage significantly increases the patient's survival chances. The existing BT detection methods often struggle with high computational complexity, limited feature discrimination, and poor generalisation.Methods: To mitigate these issues, an effective brain tumour detection and segmentation method based on A hybrid network named MobileNet- Deep Batch-Normalized eLU AlexNet (M-DbneAlexnet) is developed based on Magnetic Resonance Imaging (MRI). The image enhancement is done by Piecewise Linear Transformation (PLT) function. BT region is segmented Transformer Brain Tumour Segmentation (TransBTSV2). Then feature extraction is done. Finally, BT is detected using M-DbneAlexnet model, which is devised by combining MobileNet and Deep Batch-Normalized eLU AlexNet (DbneAlexnet).Results: The proposed model achieved an accuracy of 92.68%, sensitivity of 93.02%, and specificity of 92.85%, demonstrating its effectiveness in accurately detecting brain tumors from MRI images.Discussion: The proposed model enhances training speed and performs well on limited datasets, making it effective for distinguishing between tumor and healthy tissues. Its practical utility lies in enabling early detection and diagnosis of brain tumors, which can significantly reduce mortality rates.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-21"},"PeriodicalIF":2.7,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of 8 weeks of high-intensity interval training on hormonal and adipokines responses in people living with HIV: a non-controlled clinical trial. 8周高强度间歇训练对HIV感染者激素和脂肪因子反应的影响：一项非对照临床试验

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-07-25 DOI: 10.1080/13813455.2025.2529291

Bruno Ferrari Silva, Eloá Jacques Pastório, Gisele Cristina Bueno, Sidney Barnabé Peres, Solange Marta Franzoi de Moraes

{"title":"Effects of 8 weeks of high-intensity interval training on hormonal and adipokines responses in people living with HIV: a non-controlled clinical trial.","authors":"Bruno Ferrari Silva, Eloá Jacques Pastório, Gisele Cristina Bueno, Sidney Barnabé Peres, Solange Marta Franzoi de Moraes","doi":"10.1080/13813455.2025.2529291","DOIUrl":"https://doi.org/10.1080/13813455.2025.2529291","url":null,"abstract":"Background: To verify the effect of high-intensity interval training (HIIT) on hormonal and adipokine levels in people living with HIV (PLWH).Methods: The non-controlled clinical trial, two-arms, parallel, in 18 controls (12 women; 35.9 ± 13.3 years old; 34.5 ± 9.4% of body fat) and 19 PLWH (11 women; 41.5 ± 13.4 years old; 28.3 ± 9.1% of body fat) were allocated into separate groups without prior knowledge of the distribution. Both groups were submitted to 24 HIIT sessions of ten exercises. An incremental stress test, body composition, and blood colledtion were carried out before and after training. Data were analysed using the Shapiro-Wilk test, independent t-test, and two-way ANOVA (P < 0.05).Results: HIV- group decreased total cholesterol and triglycerides; HIV+ group decreased serum insulin, HOMA-IR index, and adiponectin; Quicky index was improved (P < 0.05).Conclusion: HIIT improves the metabolic and hormonal profile of PLWH, mainly insulin resistance and adiponectin levels.Brazilian registry of clinical trials: UTN: U1111-1231-1846.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-11"},"PeriodicalIF":2.5,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Honokiol prevents central kainic acid-induced neurodegeneration by suppressing oxidative stress, inflammation, and TGF-β1 expression. 本木酚通过抑制氧化应激、炎症和TGF-β1的表达来预防中央茴香酸诱导的神经变性。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-07-22 DOI: 10.1080/13813455.2025.2535723

Mehmet Demir, Dilan Cetinavci, Kubranur Dogan, Hulya Elbe, Ercan Saruhan

{"title":"Honokiol prevents central kainic acid-induced neurodegeneration by suppressing oxidative stress, inflammation, and TGF-β1 expression.","authors":"Mehmet Demir, Dilan Cetinavci, Kubranur Dogan, Hulya Elbe, Ercan Saruhan","doi":"10.1080/13813455.2025.2535723","DOIUrl":"https://doi.org/10.1080/13813455.2025.2535723","url":null,"abstract":"This study explored the neuroprotective effects of honokiol against oxidative stress, neuroinflammation and transforming growth factor-beta1 (TGF-β1) pathways in kainic acid (KA)-induced neurodegeneration in rats. The animals were divided into: control [Honokiol solvent (dimethyl sulphoxide), intraperitoneal for 7 days]; sham [single-dose KA solvent (saline, intracerebroventricular)]; KA (0,5 μg/μl, single-dose, intracerebroventricular); Honokiol [5 mg/kg-intraperitoneal) for 7 days]; and KA+Honokiol [KA single dose and Honokiol (for 7 days)]. Cerebral cortex and hippocampus tissues of the right hemispheres of rat brains were removed and examined biochemically and histopathologically. KA administration caused an increase in malondialdehyde levels and a decrease in reduced glutathione (GSH) and superoxide dismutase (SOD) levels. In addition, interleukin-1β levels and TGF-β1 expression were increased. Honokiol treatment decreased malondialdehyde levels, increased SOD and GSH levels, increased interleukin-1β levels and improved TGF-β1 expression in rats. Our data showed Honokiol has a protective potential against kainic acid-induced neurodegeneration by suppressing oxidative stress, inflammation and TGF-β1 expression.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-12"},"PeriodicalIF":2.5,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resistance training performed by parents modulates offspring adiposity and insulin sensitivity. 父母进行的抗阻训练调节后代的肥胖和胰岛素敏感性。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-07-21 DOI: 10.1080/13813455.2025.2533341

Fábio Henrique Dos Santos, Ana Flávia Sordi, Solange Marta Franzói De Moraes, Maria Montserrat Diaz Pedrosa, Sidney Barnabé Peres

{"title":"Resistance training performed by parents modulates offspring adiposity and insulin sensitivity.","authors":"Fábio Henrique Dos Santos, Ana Flávia Sordi, Solange Marta Franzói De Moraes, Maria Montserrat Diaz Pedrosa, Sidney Barnabé Peres","doi":"10.1080/13813455.2025.2533341","DOIUrl":"https://doi.org/10.1080/13813455.2025.2533341","url":null,"abstract":"Context: Physical exercise is one of many environmental variables that may affect an organism through epigenetic mechanisms, and thus, it may be passed on to the offspring.Objective: We assessed the effect of resistance training by the parents on mice offspring.Materials and methods: Training protocol lasted eight weeks, being males and females paired for mating. After birth, the litters were adjusted to eight pups, organised into four groups: sedentary parents (SS), trained parents (TT), sedentary fathers and trained mothers (ST), and trained fathers and sedentary mothers (TS). Male and female pups were analysed separately at the age of 21 days. One-way ANOVA or Kruskal-Wallis was applied when appropriate at the significance level of p < 0.05.Results: Resistance training improved the strength of both male and female parents. HOMA-IR index of the female offspring of groups ST and TS was improved, as well as that of the male offspring of groups TT and ST. In addition, there was a discrete reduction of adiposity in the offspring when at least one of the parents was trained.Conclusion: Therefore, parental resistance training improved insulin sensitivity and adiposity of male and female offspring suggesting resistance training as a beneficial preconception health strategy for better metabolic outcomes in future generations.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-10"},"PeriodicalIF":2.5,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of apigenin, hesperidin and their combinations on different physiopathological pathways in 5-fluorouracil-induced pulmonary damage. 芹菜素、橙皮苷及其联用对5-氟尿嘧啶致肺损伤不同生理病理通路的影响。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-07-14 DOI: 10.1080/13813455.2025.2531443

Hamit Uslu, Gözde Atila Uslu, Taha Abdulkadir Çoban, Mustafa Özkaraca, Nezahat Kurt, Ali Sefa Mendil

{"title":"Effects of apigenin, hesperidin and their combinations on different physiopathological pathways in 5-fluorouracil-induced pulmonary damage.","authors":"Hamit Uslu, Gözde Atila Uslu, Taha Abdulkadir Çoban, Mustafa Özkaraca, Nezahat Kurt, Ali Sefa Mendil","doi":"10.1080/13813455.2025.2531443","DOIUrl":"https://doi.org/10.1080/13813455.2025.2531443","url":null,"abstract":"Background: Chemotherapeutics target cancerous cells, but they also have unavoidable toxicities in healthy tissues.Aim: In this study, the effects of the commonly used chemotherapeutic 5-fluorouracil (5FU) on lung tissue were investigated, along with the possible protective benefits of apigenin (API), hesperidin (HES), and their combination.Methodology: The study consisted of control, 5FU, API + 5FU, HES + 5FU, and API+HES + 5FU groups. API 50 mg/kg and HES 200 mg/kg were administered for 7 days. On the 8th day, 5FU was administered a dose of 100 mg/kg.Results: Analyses showed that API and HES were effective in preventing oxidative stress induced by 5FU in lung tissue, attenuating inflammation and apoptosis by suppressing MAPK/NFκB and Caspase-3/Bax/Bcl-2 pathways, suppressing autophagy by decreasing LC3B expression, and regulating Sigmar1 expression.Conclusion: These results suggest that the two flavonoids, when administered separately or in combination, may be useful in reducing side effects that often occur during the use of chemotherapeutics.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-15"},"PeriodicalIF":2.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An elevated level of one-hour postprandial plasma glucose is an independent risk factor for developing chronic complications of type 2 diabetes mellitus. 餐后1小时血糖升高是2型糖尿病慢性并发症的独立危险因素。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-07-11 DOI: 10.1080/13813455.2025.2529280

Yanyan Jin, Jing Wei, Jie Yang, Hongxia Qian, Yan Wu, Mengmeng Liu

{"title":"An elevated level of one-hour postprandial plasma glucose is an independent risk factor for developing chronic complications of type 2 diabetes mellitus.","authors":"Yanyan Jin, Jing Wei, Jie Yang, Hongxia Qian, Yan Wu, Mengmeng Liu","doi":"10.1080/13813455.2025.2529280","DOIUrl":"https://doi.org/10.1080/13813455.2025.2529280","url":null,"abstract":"Context: Elevated postprandial glucose levels can help identify individuals with normal glucose tolerance who are at high risk of developing type 2 diabetes and cardiovascular complications.Objective: This study aimed to investigate the correlation between 1-hour postprandial blood glucose (1hPG) and chronic complications of T2DM, including macrovascular and microvascular diseases.Materials and methods: A total of 194 patients diagnosed with T2DM were recruited and classified into complication and non-complication groups. On the basis of the 1hPG cut-off point of 8.6 mmol/L, these patients were divided into three groups (1hPG ≥ 11.1 mmol/L, 8.6 mmol/L ≤ 1hPG < 11.1 mmol/L and 1hPG < 8.6 mmol/L). The incidence of T2DM-related chronic complications was compared among the three groups. Receiver operating characteristic (ROC) curve and logistic regression analysis were used to evaluate the predictive capability of 1hPG for T2DM-related chronic complications.Results: A higher 1hPG level was found in patients affected by T2DM combined with chronic complications than those without complications. As 1hPG level decreased, the incidence rate of chronic complications in patients with T2DM decreased, which was indicative of a positive correlation between them. According to ROC analysis, FPG, 1hPG, and 2hPG could assist in predicting occurrence of T2DM-related chronic complications, while 1hPG had stronger predictive value. More importantly, logistic regression analysis further demonstrated that increased 1hPG level was an independent risk factor for chronic complications of T2DM.Discussion and conclusion: These findings indicate that an elevated 1hPG level may be associated with an increased risk of chronic complications of T2DM.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-9"},"PeriodicalIF":2.5,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144607256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The protective effects of thymoquinone against tartrazine-induced pancreatic injury and its impact on oxidative stress, caspase 3, blood glucose, insulin and cholesterol levels. 百里醌对酒石黄诱导的胰腺损伤的保护作用及其对氧化应激、半胱天冬酶3、血糖、胰岛素和胆固醇水平的影响。

IF 2.5 4区医学

Archives of Physiology and Biochemistry Pub Date : 2025-07-10 DOI: 10.1080/13813455.2025.2531121

Zeynep Erdemli, Emrah Zayman, Nurcan Gokturk, Mehmet Gul, Nursena Demircigil, Ayse Betul Levent, Bülent Aylaz, Harika Gozukara Bag, Mehmet Erman Erdemli

{"title":"The protective effects of thymoquinone against tartrazine-induced pancreatic injury and its impact on oxidative stress, caspase 3, blood glucose, insulin and cholesterol levels.","authors":"Zeynep Erdemli, Emrah Zayman, Nurcan Gokturk, Mehmet Gul, Nursena Demircigil, Ayse Betul Levent, Bülent Aylaz, Harika Gozukara Bag, Mehmet Erman Erdemli","doi":"10.1080/13813455.2025.2531121","DOIUrl":"https://doi.org/10.1080/13813455.2025.2531121","url":null,"abstract":"The present study examined the effects of Tartrazine, a common industrial food colourant, on the pancreas and the protective role of Thymoquinone. Thirty-two Wistar albino male rats were randomly divided into four equal groups: Control, Tartrazine, Thymoquinone, and Tartrazine + Thymoquinone. The rats received Tartrazine and Thymoquinone treatments for 21 days. At the end of this period, pancreatic tissues and blood samples were collected for analysis. Tartrazine administration elevated malondialdehyde (MDA), total oxidant status (TOS), and oxidative stress index (OSI) levels, while decreasing glutathione (GSH), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), catalase (CAT), and total antioxidant status (TAS) in pancreatic tissue. It increased glucose, total cholesterol, triglycerides, and LDL levels, while decreasing insulin and HDL levels in blood samples. Tartrazine administration aggravated pancreatic histopathology and enhanced Caspase-3 positive immunoreactivity. Thymoquinone administration reduced the harmful effects of Tartrazine on biochemical and histopathological parameters. Tartrazine administration negatively impacted pancreatic tissue and blood samples. The increased oxidant capacity and oxidative stress led to these harmful effects. Conversely, Thymoquinone alleviated oxidative stress by increasing antioxidant capacity and could act as a protective agent.","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"1-11"},"PeriodicalIF":2.5,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0