Resistance training performed by parents modulates offspring adiposity and insulin sensitivity.

IF 2.5 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Archives of Physiology and Biochemistry Pub Date : 2025-07-21 DOI:10.1080/13813455.2025.2533341

Fábio Henrique Dos Santos, Ana Flávia Sordi, Solange Marta Franzói De Moraes, Maria Montserrat Diaz Pedrosa, Sidney Barnabé Peres

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引用次数: 0

Abstract

Context: Physical exercise is one of many environmental variables that may affect an organism through epigenetic mechanisms, and thus, it may be passed on to the offspring.

Objective: We assessed the effect of resistance training by the parents on mice offspring.

Materials and methods: Training protocol lasted eight weeks, being males and females paired for mating. After birth, the litters were adjusted to eight pups, organised into four groups: sedentary parents (SS), trained parents (TT), sedentary fathers and trained mothers (ST), and trained fathers and sedentary mothers (TS). Male and female pups were analysed separately at the age of 21 days. One-way ANOVA or Kruskal-Wallis was applied when appropriate at the significance level of p < 0.05.

Results: Resistance training improved the strength of both male and female parents. HOMA-IR index of the female offspring of groups ST and TS was improved, as well as that of the male offspring of groups TT and ST. In addition, there was a discrete reduction of adiposity in the offspring when at least one of the parents was trained.

Conclusion: Therefore, parental resistance training improved insulin sensitivity and adiposity of male and female offspring suggesting resistance training as a beneficial preconception health strategy for better metabolic outcomes in future generations.

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父母进行的抗阻训练调节后代的肥胖和胰岛素敏感性。

背景：体育锻炼是可能通过表观遗传机制影响生物体的众多环境变量之一，因此，它可能会传递给后代。目的：观察亲本抗阻训练对小鼠后代的影响。材料与方法：训练方案持续8周，雌雄配对交配。出生后，一窝狗被调整到8只，分为四组：久坐的父母（SS），训练有素的父母（TT），久坐的父亲和训练有素的母亲（ST），以及训练有素的父亲和久坐的母亲（TS）。在21日龄时分别对雄性和雌性幼崽进行分析。在p的显著性水平上应用单因素方差分析或Kruskal-Wallis结果：阻力训练提高了男女父母的力量。ST组和TS组雌性后代的HOMA-IR指数有所提高，TT组和ST组雄性后代的HOMA-IR指数也有所提高。此外，当父母中至少有一方接受训练时，后代的肥胖程度有离散性降低。结论：因此，父母抗阻训练改善了雄性和雌性后代的胰岛素敏感性和肥胖，这表明抗阻训练是一种有益的孕前健康策略，可以改善后代的代谢结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Physiology and Biochemistry ENDOCRINOLOGY & METABOLISM-PHYSIOLOGY

CiteScore

6.90

自引率

3.30%

发文量

期刊介绍： Archives of Physiology and Biochemistry: The Journal of Metabolic Diseases is an international peer-reviewed journal which has been relaunched to meet the increasing demand for integrated publication on molecular, biochemical and cellular aspects of metabolic diseases, as well as clinical and therapeutic strategies for their treatment. It publishes full-length original articles, rapid papers, reviews and mini-reviews on selected topics. It is the overall goal of the journal to disseminate novel approaches to an improved understanding of major metabolic disorders. The scope encompasses all topics related to the molecular and cellular pathophysiology of metabolic diseases like obesity, type 2 diabetes and the metabolic syndrome, and their associated complications. Clinical studies are considered as an integral part of the Journal and should be related to one of the following topics: -Dysregulation of hormone receptors and signal transduction -Contribution of gene variants and gene regulatory processes -Impairment of intermediary metabolism at the cellular level -Secretion and metabolism of peptides and other factors that mediate cellular crosstalk -Therapeutic strategies for managing metabolic diseases Special issues dedicated to topics in the field will be published regularly.