Effects of 8 weeks of high-intensity interval training on hormonal and adipokines responses in people living with HIV: a non-controlled clinical trial.

IF 2.5 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Archives of Physiology and Biochemistry Pub Date : 2025-07-25 DOI:10.1080/13813455.2025.2529291

Bruno Ferrari Silva, Eloá Jacques Pastório, Gisele Cristina Bueno, Sidney Barnabé Peres, Solange Marta Franzoi de Moraes

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Abstract

Background: To verify the effect of high-intensity interval training (HIIT) on hormonal and adipokine levels in people living with HIV (PLWH).

Methods: The non-controlled clinical trial, two-arms, parallel, in 18 controls (12 women; 35.9 ± 13.3 years old; 34.5 ± 9.4% of body fat) and 19 PLWH (11 women; 41.5 ± 13.4 years old; 28.3 ± 9.1% of body fat) were allocated into separate groups without prior knowledge of the distribution. Both groups were submitted to 24 HIIT sessions of ten exercises. An incremental stress test, body composition, and blood colledtion were carried out before and after training. Data were analysed using the Shapiro-Wilk test, independent t-test, and two-way ANOVA (P < 0.05).

Results: HIV- group decreased total cholesterol and triglycerides; HIV+ group decreased serum insulin, HOMA-IR index, and adiponectin; Quicky index was improved (P < 0.05).

Conclusion: HIIT improves the metabolic and hormonal profile of PLWH, mainly insulin resistance and adiponectin levels.

Brazilian registry of clinical trials: UTN: U1111-1231-1846.

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8周高强度间歇训练对HIV感染者激素和脂肪因子反应的影响：一项非对照临床试验

背景：验证高强度间歇训练（HIIT）对HIV感染者（PLWH）激素和脂肪因子水平的影响。方法：非对照临床试验，双臂，平行，18例对照(女性12例；35.9±13.3岁；34.5±9.4%体脂)、PLWH 19例(女性11例；41.5±13.4岁；（28.3±9.1%），在事先不知道其分布情况的情况下被分成不同的组。两组都进行了24次HIIT训练，每组10次。在训练前后分别进行了压力测试、身体成分和血液采集。使用Shapiro-Wilk检验、独立t检验和双向方差分析(P)对数据进行分析。结果：HIV组总胆固醇和甘油三酯降低；HIV+组血清胰岛素、HOMA-IR指数、脂联素降低；结论：HIIT改善了PLWH的代谢和激素特征，主要是胰岛素抵抗和脂联素水平。巴西临床试验注册：UTN: U1111-1231-1846。

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来源期刊

Archives of Physiology and Biochemistry ENDOCRINOLOGY & METABOLISM-PHYSIOLOGY

CiteScore

6.90

自引率

3.30%

发文量

期刊介绍： Archives of Physiology and Biochemistry: The Journal of Metabolic Diseases is an international peer-reviewed journal which has been relaunched to meet the increasing demand for integrated publication on molecular, biochemical and cellular aspects of metabolic diseases, as well as clinical and therapeutic strategies for their treatment. It publishes full-length original articles, rapid papers, reviews and mini-reviews on selected topics. It is the overall goal of the journal to disseminate novel approaches to an improved understanding of major metabolic disorders. The scope encompasses all topics related to the molecular and cellular pathophysiology of metabolic diseases like obesity, type 2 diabetes and the metabolic syndrome, and their associated complications. Clinical studies are considered as an integral part of the Journal and should be related to one of the following topics: -Dysregulation of hormone receptors and signal transduction -Contribution of gene variants and gene regulatory processes -Impairment of intermediary metabolism at the cellular level -Secretion and metabolism of peptides and other factors that mediate cellular crosstalk -Therapeutic strategies for managing metabolic diseases Special issues dedicated to topics in the field will be published regularly.