From the gut to the heart: probiotic therapy with Saccharomyces boulardii and its potential role on diabetic cardiomyopathy in a murine model.

IF 2.7 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Archives of Physiology and Biochemistry Pub Date : 2025-07-31 DOI:10.1080/13813455.2025.2539188

Ana Beatriz P Brandão, Raquel C M F Albuquerque, Isabel C M E de Abreu, Fabiana G Ferreira, Leticia B Santos, Leonardo Jensen, Leandro Eziquiel de Souza, Sarah G Ferreira, Lívia B de Souza, Emília Lo Schiavo, Luciana Sant Anna, Elisa M Higa, Adenauer Casali, Flávio Aimbire, Maria Claudia C Irigoyen, Karina R Casali, Tatiana S Cunha

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引用次数: 0

Abstract

Background: We investigated whether the probiotic yeast Saccharomyces boulardii confers cardiometabolic protection and prevents diabetic cardiomyopathy by modulating inflammation, cardiac remodelling, cardiovascular function, and autonomic regulation.

Methods: Male C57BL/6 mice were allocated into four groups: Control (C), Diabetes (DM), Control+Saccharomyces boulardii (CSb), and Diabetes+Saccharomyces boulardii (DMSb). Diabetes was induced with intraperitoneal streptozotocin (STZ), and treatments (sterile water or Saccharomyces boulardii) were administered orally for 8 weeks. Blood glucose, cytokines, and nitric oxide levels were measured, along with cardiac function via echocardiography and direct blood pressure recordings.

Results: Saccharomyces boulardii reduced blood glucose and increased cardiac IL-10 in diabetic mice, restoring nitric oxide levels. These effects were associated to reduced collagen deposition, preventing vascular damage and ventricular fibrosis, and were accompanied by improved systolic/diastolic function and autonomic control.

Conclusion: Saccharomyces boulardii improved cardiac structure, function, and autonomic control in diabetic mice, supporting its potential as adjunct therapy for diabetic cardiomyopathy.

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从肠道到心脏：博氏酵母菌的益生菌治疗及其在小鼠糖尿病心肌病模型中的潜在作用

背景：我们研究了博氏酵母菌是否通过调节炎症、心脏重构、心血管功能和自主调节来提供心脏代谢保护和预防糖尿病性心肌病。方法：将雄性C57BL/6小鼠分为4组：对照组(C)、糖尿病组（DM）、对照组+博氏酵母菌组（CSb）和糖尿病组+博氏酵母菌组（DMSb）。腹腔注射链脲佐菌素（STZ）诱导糖尿病，口服无菌水或博氏酵母菌治疗8周。通过超声心动图和直接血压记录测量血糖、细胞因子和一氧化氮水平以及心功能。结果：博拉氏酵母菌降低糖尿病小鼠血糖，增加心脏IL-10，恢复一氧化氮水平。这些作用与减少胶原沉积，防止血管损伤和心室纤维化有关，并伴有改善的收缩/舒张功能和自主控制。结论：博氏酵母菌改善了糖尿病小鼠的心脏结构、功能和自主神经控制，支持其作为糖尿病心肌病辅助治疗的潜力。

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来源期刊

Archives of Physiology and Biochemistry ENDOCRINOLOGY & METABOLISM-PHYSIOLOGY

CiteScore

6.90

自引率

3.30%

发文量

期刊介绍： Archives of Physiology and Biochemistry: The Journal of Metabolic Diseases is an international peer-reviewed journal which has been relaunched to meet the increasing demand for integrated publication on molecular, biochemical and cellular aspects of metabolic diseases, as well as clinical and therapeutic strategies for their treatment. It publishes full-length original articles, rapid papers, reviews and mini-reviews on selected topics. It is the overall goal of the journal to disseminate novel approaches to an improved understanding of major metabolic disorders. The scope encompasses all topics related to the molecular and cellular pathophysiology of metabolic diseases like obesity, type 2 diabetes and the metabolic syndrome, and their associated complications. Clinical studies are considered as an integral part of the Journal and should be related to one of the following topics: -Dysregulation of hormone receptors and signal transduction -Contribution of gene variants and gene regulatory processes -Impairment of intermediary metabolism at the cellular level -Secretion and metabolism of peptides and other factors that mediate cellular crosstalk -Therapeutic strategies for managing metabolic diseases Special issues dedicated to topics in the field will be published regularly.