Archives of Gynecology and Obstetrics最新文献

{"title":"Effects of autologous platelet-rich plasma intrauterine perfusion on clinical outcomes in recurrent implantation failure patients with non-thin endometrium undergoing frozen-thawed embryo transfer","authors":"Xiao-Hui Liu,&nbsp;Li-Xia He,&nbsp;Man Li,&nbsp;Zheng-Ping Tian,&nbsp;An-Qi Qin,&nbsp;Jun Yao","doi":"10.1007/s00404-025-07983-y","DOIUrl":"10.1007/s00404-025-07983-y","url":null,"abstract":"<div><h3>Purpose</h3><p>To explore the effects of autologous platelet-rich plasma (PRP) intrauterine perfusion on clinical outcomes in recurrent implantation failure (RIF) patients with non-thin endometrium undergoing frozen-thawed embryo transfer (FET), and the effects of PRP used at different times before FET on clinical outcomes.</p><h3>Methods</h3><p>A total of 160 RIF patients with non-thin endometrium undergoing FET were retrospectively analyzed. Among them, 82 patients received PRP intrauterine perfusion at 24–72 h before FET (PRP group), and 78 patients did not (non-PRP group). In PRP group, 59 patients underwent PRP at 24–48 h before FET (≥ 24 to  ≤ 48 h group), and 23 patients was at 48–72 h (&gt; 48 to  ≤ 72 h group). The clinical outcomes were compared, including β-hCG positive rate, clinical pregnancy rate, embryo implantation rate, abortion rate, ectopic pregnancy rate, live birth rate and the incidence of adverse events.</p><h3>Results</h3><p>The clinical pregnancy rate, embryo implantation rate and live birth rate in PRP group were significantly higher than those in non-PRP group (<i>P</i> &lt; 0.05), and there were no statistical differences in β-hCG rate, abortion rate and ectopic pregnancy rate between the two groups (<i>P</i> &gt; 0.05). Meanwhile, there was no adverse events occurred in PRP group. However, the C-type endometrium rate in PRP group was observably higher on FET day (<i>Χ</i>² = 8.309, <i>P</i> = 0.004), though there was no statistical difference in endometrial thickness (<i>P</i> &gt; 0.05). The multiple logistics regression analysis showed that PRP intrauterine perfusion are closely related with clinical pregnancy and live birth in RIF patients with non-thin endometrium (OR: 2.379, 95% CI 1.137–4.977, <i>P</i> = 0.021; OR: 2.107, 95% CI 1.006–4.412, <i>P</i> = 0.048). Moreover, we found no significant difference in clinical outcomes between the two groups of PRP intrauterine perfusion at ≥ 24 to ≤ 48 h and &gt; 48 to ≤ 72 h before FET (<i>P</i> &gt; 0.05), except for β-hCG positive rate.</p><h3>Conclusions</h3><p>PRP intrauterine perfusion can safely and effectively improve the clinical pregnancy rate, implantation rate and live birth rate in RIF patients with non-thin endometrium possibly by increasing the C-type endometrium rate on FET day. In addition, PRP intrauterine perfusion at different times of 24–72 h before FET does not affect the clinical outcomes, which will be helpful to guide clinical work flexibly.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"311 5","pages":"1423 - 1433"},"PeriodicalIF":2.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-025-07983-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The “popcorn” sign: the first early ultrasound sign of serous intra-parenchymal ovarian cancer in BRCA mutation carriers","authors":"Giovanni Grandi,&nbsp;Alice Sgandurra,&nbsp;Laura Cortesi,&nbsp;Angela Toss,&nbsp;Massimo Dominici,&nbsp;Valentina Grisendi,&nbsp;Valeria Pedrini,&nbsp;Laura Botticelli,&nbsp;Antonio La Marca","doi":"10.1007/s00404-025-08010-w","DOIUrl":"10.1007/s00404-025-08010-w","url":null,"abstract":"","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"311 5","pages":"1461 - 1465"},"PeriodicalIF":2.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-025-08010-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value of CODAC classification in identifying causes of stillbirths.","authors":"Karima Mekni, Hyem Khiari, Ameni Tissaoui, Khaoula Belaid, Imène Habassi, Chiraz Elfekih","doi":"10.1007/s00404-025-07955-2","DOIUrl":"https://doi.org/10.1007/s00404-025-07955-2","url":null,"abstract":"<p><strong>Purpose: </strong>Stillbirth is a public health problem and one of the main obstetrical complications of pregnancy that practitioners can ever witness. A careful etiological investigation and a search for risk factors is necessary. The main objective of our study was to identify the causes of stillbirths using the CODAC classification system.</p><p><strong>Methods: </strong>It was a monocentric retrospective descriptive study conducted over 5 years in our gynecology department. We collected 114 cases.</p><p><strong>Results: </strong>The overall frequency was 8.26 ‰. The average age of women was 32.19 years. Women came from an urban environment in 48.2% and had a low level of education in 54.4% of cases. Our patients were moderately obese (48%). A history of stillbirth was found in 33 cases (28.9%), and the average term of pregnancy was 32 weeks' gestation. Pregnancy was poorly monitored in 2/3 of the population studied. The most frequent reason for consultation was a decrease/absence of fetal movement perception (30%). Labor was induced in 53.5% of deliveries. Delivery was by vaginal route in 58% of cases and the male sex was predominant (61%). For funicular anomalies, a placental abruption was found in 21.1% of cases, and a cord loop in 11.4%. For the etiological investigation via the CODAC classification, maternal pathologies were the most frequent with 28.07% of cases dominated by hypertension. Placental pathologies (placental abruption) and cord abnormalities (cord loop) represented, respectively, 22 and 21.05%. An unexplained cause was found in 20.17%.</p><p><strong>Conclusions: </strong>For the etiological investigation, we relied on the CODAC classification to minimize unexplained causes. This etiological investigation is essential not only to provide answers for the bereaved couple but also to prevent the recurrence of such incidents in subsequent pregnancies.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of dysmenorrhea-related factors in adenomyosis and development of a risk prediction model","authors":"Yudan Fu,&nbsp;Xin Wang,&nbsp;Xinchun Yang,&nbsp;Ruihua Zhao","doi":"10.1007/s00404-025-07967-y","DOIUrl":"10.1007/s00404-025-07967-y","url":null,"abstract":"<div><h3>Objective</h3><p>To explore factors related to dysmenorrhea in adenomyosis and construct a risk prediction model.</p><h3>Methods</h3><p>A cross-sectional survey involving 1636 adenomyosis patients from 37 hospitals nationwide (November 2019–February 2022) was conducted. Data on demographics, disease history, menstrual and reproductive history, and treatment history was collected.Patients were categorized into dysmenorrhea and non-dysmenorrhea groups. Multivariate logistic regression analyzed factors influencing dysmenorrhea, and a risk prediction model was created using a nomogram. The model’s performance was evaluated through ROC curve analysis, C-index, Hosmer–Lemeshow test, and bootstrap method The nomogram function was used to establish a nomogram model. The model was evaluated using the area under the ROC curve (AUC), C-index, Hosmer–Lemeshow goodness-of-fit test, and bootstrap method. Patients were scored based on the nomogram, and high-risk groups were delineated.</p><h3>Results</h3><p>Dysmenorrhea was present in 61.31% (1003/1636) of the patients. Univariate analysis showed significant differences (P &lt; 0.05) between groups in age at onset, course of disease, oligomenorrhea, menorrhagia, number of deliveries, pelvic inflammatory disease, family history of adenomyosis, exercise, and excessive menstrual fatigue. Significant factors included menorrhagia, multiple deliveries, pelvic inflammatory disease, and family history of adenomyosis as risk factors. Older age at onset, oligomenorrhea, and exercise were identified as protective factors. The model’s accuracy, discrimination, and reliability were acceptable, and a risk score &gt; 88.5 points indicated a high-risk group.</p><h3>Conclusion</h3><p>Dysmenorrhea is prevalent among adenomyosis patients. Identifying and mitigating risk factors, while leveraging protective factors, can aid in prevention and management. The developed model effectively predicts dysmenorrhea risk, facilitating early intervention and treatment.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"311 4","pages":"1081 - 1089"},"PeriodicalIF":2.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-025-07967-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthy lifestyle behaviors and gynecological cancer awareness in women academicians: a descriptive and correlational study","authors":"Rabiye Akin Işik,&nbsp;Ayşe Arikan Dönmez,&nbsp;Füsun Terzioğlu","doi":"10.1007/s00404-024-07907-2","DOIUrl":"10.1007/s00404-024-07907-2","url":null,"abstract":"<div><h3>Objective</h3><p>To determine the healthy lifestyle behaviors (HLBs) and gynecological cancer awareness (GCA) levels of women academicians and to investigate the correlation between HLBs and GCA.</p><h3>Methods</h3><p>A descriptive correlational study design was used to determine the healthy life behaviors and gynecological cancer awareness levels of women academicians and to investigate the correlation between them. A total of 353 women academicians were included between 1st March 2020 and 1st January 2021. The data were collected using Introductory Form, Health Promoting Lifestyle Profile II, and Gynecological Cancer Awareness Scale.</p><h3>Results</h3><p>The women’s healthy life behaviors levels were close to moderate and gynecological cancer awareness levels were high. The median healthy life behaviors score was significantly higher in women who worked as an assistant professor, considered the age of menarche and menopause as risk factors for women cancers, consumed regular snacks, received information about GCs, and had regular pap-smears (<i>p</i> &lt; .05). The median gynecological cancer awareness score was significantly higher in women who worked as an assistant professor, considered the age of menarche and menopause as risk factors for women cancers, received information about GCs, and experienced pregnancy process (<i>p</i> &lt; .05). In addition, as women’s healthy life behaviors levels increased, their gynecological cancer awareness levels also increased. The healthy life behaviors score was positively and moderately associated with the gynecological cancer awareness score (<i>p</i> &lt; .05).</p><h3>Discussion</h3><p>Our findings highlight the potential to promote monitoring of women’s healthy lifestyle behaviors and gynecological cancer awareness in the community by planning effective interventions.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"311 5","pages":"1379 - 1393"},"PeriodicalIF":2.1,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-024-07907-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Evaluation of endocervical curettage (ECC) in colposcopy for detecting cervical intraepithelial lesions","authors":"Annika S. Behrens,&nbsp;Anna K. Dietl,&nbsp;Werner Adler,&nbsp;Carol Geppert,&nbsp;Arndt Hartmann,&nbsp;Antje Knöll,&nbsp;Matthias W. Beckmann,&nbsp;Grit Mehlhorn,&nbsp;Martin C. Koch,&nbsp;Carla E. Schulmeyer,&nbsp;A. Seibold,&nbsp;Paul Gass,&nbsp;Frederik A. Stuebs","doi":"10.1007/s00404-025-07993-w","DOIUrl":"10.1007/s00404-025-07993-w","url":null,"abstract":"","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"311 4","pages":"1227 - 1228"},"PeriodicalIF":2.1,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-025-07993-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Favorable outcome after fetal swallowing of a Somatex® intrauterine shunt","authors":"A. Rejaey,&nbsp;I. Gottschalk,&nbsp;E. C. Weber,&nbsp;A. Messling,&nbsp;J. Hubertus,&nbsp;C. Berg","doi":"10.1007/s00404-025-07992-x","DOIUrl":"10.1007/s00404-025-07992-x","url":null,"abstract":"","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"311 4","pages":"1229 - 1229"},"PeriodicalIF":2.1,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-025-07992-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Twin delivery: does induction of labor make a difference?","authors":"L Rüegg, L Vonzun, J Wawrla-Zepf, F Krähenmann, N Ochsenbein-Kölble","doi":"10.1007/s00404-025-07939-2","DOIUrl":"https://doi.org/10.1007/s00404-025-07939-2","url":null,"abstract":"<p><strong>Purpose: </strong>Induction of labor as well as delivery in twin pregnancies bears specific risks. The goal of this study was to analyze the delivery mode in twin pregnancies and influence of induction on the cesarean delivery (CD) rate and perinatal outcome and to identify risk factors for CD and an intertwin interval ≥ 15 min.</p><p><strong>Methods: </strong>This single-center retrospective cohort study analyzed the outcome of 267 twin pregnancies. Inclusion criteria for vaginal delivery in twins are gestational age (GA) > 34 weeks, leading twin in cephalic presentation, estimated weight difference ≤ 500 g and no previous uterine surgery. Women were divided into three groups: 1 = vaginal delivery, 2 = CD for both twins, 3 = emergency CD for second twin. Outcomes were mode of delivery, and influence of induction on the CD rate.</p><p><strong>Results: </strong>We had 156 women (58%) in group 1, 97 (36%) in 2 and 14 (5%) in 3. Induction of labor was performed in 147 cases and led to a higher CD rate (23% vs. 47%, p < 0.001). Induction of labor and nulliparity were associated with a higher risk for CD for both twins. Risk factors for an intertwin interval of ≥ 15 min were maternal age and weight of the second twin. An intertwin interval of ≥ 15 min was associated with a lower umbilical artery pH in the second twin.</p><p><strong>Conclusion: </strong>The rate of CD doubled if induction of labor was necessary. These results emphasize on careful patient counseling that includes information about the risks of deliveries in twin pregnancies.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143622974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inherited thrombophilias and stillbirth: a systematic review and meta- analysis.","authors":"Michail Delis, Elpida Emmanouilidou-Fotoulaki, Christos Chatzakis, Theodoros Theodoridis, Alexandros Sotiriadis","doi":"10.1007/s00404-025-07989-6","DOIUrl":"https://doi.org/10.1007/s00404-025-07989-6","url":null,"abstract":"<p><strong>Purpose: </strong>The association between inherited thrombophilias and stillbirth has been long investigated but the estimated risk remains unknown. The aim of our study is to summarize available data on the effect of Factor V Leiden, Prothrombin G20210A and MTHFR mutation, Protein S, Protein C and Anithrombin deficiency on the prevalence of stillbirth.</p><p><strong>Methods: </strong>We conducted a systematic review and meta- analysis of all relevant available PubMed, Embase and Cochrane studies until February 2024. A sensitivity analysis of only prospective and retrospective studies was performed.</p><p><strong>Results: </strong>Based on 31 included studies, Factor V Leiden and Prothrombin G202110A mutations, significantly rise the prevalence of stillbirth with a pooled OR 2.35 (95% CI 1.74-3.17) and 2.62 (95% CI 1.79-3.84), respectively. This positive correlation did not change in the sensitivity analysis. Positive correlation was also found between Antithrombin deficiency and stillbirth with a pooled OR 3.97 (95% CI 1.50-10.48). No statistically significant relationship was found between stillbirth and MTHFR mutation or Protein C and Protein S deficiency according to the random effects model.</p><p><strong>Conclusion: </strong>Our findings suggest that in the presence of certain inherited thrombophilias, the occurrence of intrauterine fetal death is significantly more prevalent.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the female genital tract microbiome and its association with hydrosalpinx in women undergoing salpingectomy","authors":"Yael Yagel,&nbsp;Yair Motro,&nbsp;Stefan Green,&nbsp;Hadar Klapper-Goldstein,&nbsp;Ella Pardo,&nbsp;Jacob Moran-Gilad,&nbsp;Adi Y. Weintraub","doi":"10.1007/s00404-025-07944-5","DOIUrl":"10.1007/s00404-025-07944-5","url":null,"abstract":"<div><h3>Objective</h3><p>To describe the microbiome of the vagina and fallopian tubes (FT) and its relation with hydrosalpinx.</p><h3>Methods</h3><p>Case–control study was conducted in women who underwent salpingectomy for hydrosalpinx (case) or other indications (controls). Samples were obtained during surgery and subjected to 16S rRNA amplicon sequencing, and analyses of alpha diversity and beta diversity measures were compared between sites and groups. Differential abundance of bacteria associated with vaginal dysbiosis was compared between cases and controls.</p><h3>Results</h3><p>Nine women with hydrosalpinx and 23 women without hydrosalpinx were included in the study. The mean age of studied women was 41 (range: 29–54) and most (89%) were premenopausal. After in silico decontamination, only 30% of control FT samples and 10% of case FT samples had evidence of bacterial presence. The vaginal microbiome of control patients showed greater abundance of lactobacilli, whereas the vaginal microbiome of case patients contained relatively more bacterial vaginosis-associated bacteria, such as <i>Prevotella</i> and <i>Atopobium</i>. A significant difference was found in alpha and beta diversity between vaginal and FT microbiomes in control patients as FT samples were more diverse. We found that women with hydrosalpinx had a more “dysbiotic” vaginal microbiome and in women without hydrosalpinx, microbial composition within the vagina and FT differed, possibly representing two distinct ecological environments.</p><h3>Conclusion</h3><p>Women undergoing salpingectomy for various reasons harbored bacteria within their FT, while women with hydrosalpinx generally did not. This suggests that even though infection may be an underlying cause of hydrosalpinx, bacteria may not be present by the time patients require surgery.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"311 6","pages":"1649 - 1656"},"PeriodicalIF":2.1,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-025-07944-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143622962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}