Archives of Gynecology and Obstetrics最新文献

{"title":"Impact of sexual activity on bulbocavernosus muscle stiffness assessed by shear wave elastography in women","authors":"Rui Du,&nbsp;Linyue Wang,&nbsp;Yan Li,&nbsp;Wei Qiao,&nbsp;Huijuan Xiang,&nbsp;Li Yang","doi":"10.1007/s00404-025-08024-4","DOIUrl":"10.1007/s00404-025-08024-4","url":null,"abstract":"<div><h3>Purpose</h3><p>The bulbocavernosus muscle (BCM) is a vital component of the pelvic floor muscles, significantly contributing to women’s sexual function. Shear wave elastography (SWE) is an innovative, non-invasive imaging technique offering quantitative insights into tissue stiffness, yet its application in evaluating BCM stiffness remains unexplored. This study investigates the stiffness of the BCM in women with different sexual activity histories using SWE.</p><h3>Methods</h3><p>This cross-sectional study was conducted at a tertiary hospital in China between April and September 2024. Sixty-two women aged 18 to 40 were assigned to two groups: the sexually active group (SAG) and the sexually inactive group (SIG). BCM stiffness was measured at rest and during maximal voluntary contraction (MVC). The correlations between BCM stiffness and the Female Sexual Function Index (FSFI) scores were also examined.</p><h3>Results</h3><p>Women in the SAG exhibited significantly higher BCM stiffness during MVC compared to those in the SIG, and BCM stiffness during MVC was moderately correlated with the orgasm domain of the FSFI. There were no significant differences in BCM stiffness at rest between the two groups.</p><h3>Conclusion</h3><p>Sexual activity may positively influence BCM stiffness, which could lead to improved pelvic floor muscle function and potentially enhance sexual health. A moderate correlation between BCM stiffness during MVC and the orgasm domain of the FSFI, suggesting a possible biomechanical association between BCM function and sexual function. Further research is needed to confirm this relationship and explore its clinical implications.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"311 6","pages":"1743 - 1750"},"PeriodicalIF":2.1,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-025-08024-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143908702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Predictive value of urine misfolded protein in preeclampsia in twin pregnancies","authors":"Qiufeng Liang,&nbsp;Luming Sun","doi":"10.1007/s00404-025-08026-2","DOIUrl":"10.1007/s00404-025-08026-2","url":null,"abstract":"","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"311 6","pages":"1765 - 1765"},"PeriodicalIF":2.1,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-025-08026-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143908703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Assessment of psychological distress in patients with cervical dysplasia according to age, education, information acquisition and information level","authors":"Anne Cathrine Scherer-Quenzer,&nbsp;Saskia-Laureen Herbert,&nbsp;Tanja Schlaiss,&nbsp;Achim Wöckel,&nbsp;Joachim Diessner,&nbsp;Jan-Peter Grunz,&nbsp;Jelena Findeis,&nbsp;Matthias Kiesel","doi":"10.1007/s00404-025-08011-9","DOIUrl":"10.1007/s00404-025-08011-9","url":null,"abstract":"","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"311 5","pages":"1475 - 1475"},"PeriodicalIF":2.1,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-025-08011-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Second trimester soft markers: still worth to be mentioned?","authors":"Karl Oliver Kagan,&nbsp;Markus Hoopmann,&nbsp;Jiri Sonek","doi":"10.1007/s00404-025-08021-7","DOIUrl":"10.1007/s00404-025-08021-7","url":null,"abstract":"<div><p>Despite the widespread use of cell-free DNA in screening for trisomy 21, soft markers continue to be assessed in the second trimester, leading to confusion about how they affect the risk of trisomy 21, especially after an earlier screening test such as cell-free DNA screening. In this review, we provide an overview of commonly used second trimester soft markers, explain how they can be used to calculate the risk for trisomy 21, and discuss what other chromosomal or structural abnormalities might be associated with these markers. We especially focus on pathogenic copy number variants as these, in aggregate, are common and are very difficult to detect using cfDNA or even standard karyotyping.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"311 5","pages":"1233 - 1240"},"PeriodicalIF":2.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-025-08021-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of risk and lifestyle factors on therapy goals in the treatment of breast cancer and gynecological cancer patients with integrative medicine","authors":"Katharina Seitz,&nbsp;Anna-Katharin Theuser,&nbsp;Sophia Antoniadis,&nbsp;Matthias W. Beckmann,&nbsp;Milena Beierlein,&nbsp;L. Brückner,&nbsp;Katharina Au,&nbsp;Carolin C. Hack","doi":"10.1007/s00404-025-08002-w","DOIUrl":"10.1007/s00404-025-08002-w","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;p&gt;As a result of advancements in the diagnosis and therapy of cancer, the prognosis for cancer patients has significantly improved. The benefits of a significantly enhanced survival time lead to a more extensive concern with quality of life and managing the side effects during oncological treatment. Implementing integrative medicine strategies has been found to reduce the side effects of therapy and disease. In 2021 the S3 guideline on complementary medicine in oncology was published for the first time, which takes a stand on the most common aspects of complementary and integrative medicine in Germany. The aim was to see whether a previous healthy life style impacts the success of integrative medicine for patients.&lt;/p&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;p&gt;Within the framework of a cross-sectional study over 15 months, 120 cancer patients were monitored at a standardized integrative medicine consultancy service at the University Integrative Medicine Center of the University Hospital Erlangen, Department of Gynecology and Obstetrics. The basic questionnaire consisted of questions on socioeconomic background information, lifestyle factors, such as dietary habits or smoking behavior, as well as information on the gynecological situation. Furthermore, an evaluation based on patient-reported therapy goals concerning the reduction of side effects of conventional cancer treatments, enhancement of disease-related quality of life and better stress and disease management, active participation in cancer treatments, mind–body stabilization, and improvements in coping strategies were assessed. In addition, the impact of patient characteristics and lifestyle on the subjective achievement of these outcomes was evaluated to set the answers in context and show its influence. Statistical analysis was performed using SPSS Statistics for Windows version 26 (IBM Corporation, Armonk in New York, USA). Mean, standard deviation, minimum, and maximum were calculated for age and BMI. The other characteristics regarding demographics, lifestyle, tumor disease, and therapy were analyzed based on their respective absolute and relative frequencies.&lt;/p&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;p&gt;A large majority of the patients' participation goal was to reduce cancer-related side effects (90.8%), second were the aspects of “Improvement of the disease-related quality of life “(72.5%). In both cases, this common goal was only fully achieved for about one quarter of the patients (25.7%/24.1%), but partially achieved in more than half of the asked patients (53.2%/52.9%). Half of the patients reported that they achieved active participation in cancer treatment with integrative medicine. Around 50% partially achieved stabilization of the body, soul, and spirit, stress, disease management, improvement in cancer-related quality of life, and reduced the side effects of conventional cancer therapies. The success of integrative therapy was independent of age, BMI, family status, children, level of education","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"311 6","pages":"1683 - 1695"},"PeriodicalIF":2.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-025-08002-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143908826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Care of pregnant women with pre-existing medical conditions in German perinatal centers.","authors":"P Kosian, B Strizek, S Kehl, M Abou-Dakn, E Jost, W M Merz","doi":"10.1007/s00404-025-08016-4","DOIUrl":"https://doi.org/10.1007/s00404-025-08016-4","url":null,"abstract":"<p><strong>Introduction: </strong>Pregnancies in women with chronic medical conditions are characterized by a higher maternal and perinatal complication rate during pregnancy, childbirth, and the postpartum period. The German Maternity Guideline does not provide specific recommendations for the care of these women. The aim of this study was to evaluate the care of pregnant women with pre-existing medical conditions in German perinatal centers (Level 1 and 2) and perinatal care level 3 hospitals.</p><p><strong>Materials and methods: </strong>Based on guidelines and literature, seven topics were identified: preconception counseling, timing of consultation, care for pregnant women with rare diseases, participation in continuing education, multidisciplinary case conferences, resources for patient counseling, and transfer of the patient to another center. Representatives of all perinatal centers were contacted by email and invited to participate. The anonymous online survey was conducted using the SoSci Survey platform.</p><p><strong>Results: </strong>Of 310 centers, 103 (33.2%) representatives responded. 62.2% (n = 64) reported managing 11-30 pregnant women with pre-existing conditions per month. 22.1% (n = 23) of all centers regularly care for pregnant women with rare diseases, and 46.6% offer preconception counseling. University hospitals offer these services more frequently. Regular case conferences are held in 34.0% of centers, and 80.6% of medical staff regularly participate in continuing education on the topic.</p><p><strong>Conclusion: </strong>According to the results of our survey, 76.7% (n = 79) of perinatal centers regularly care for patients with pre-existing conditions, while only 22.1% care for patients with rare diseases. The findings highlight the need to implement standardized recommendations and targeted resource allocation to ensure optimal care for this patient group.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of early diagnosis of endometriosis on quality of life","authors":"Mania Kaveh,&nbsp;Maryam Nakhaee Moghadam,&nbsp;Mojtaba Safari,&nbsp;Shahla Chaichian,&nbsp;Abolfazl Mehdizadeh Kashi,&nbsp;Mehdi Afshari,&nbsp;Kambiz Sadegi","doi":"10.1007/s00404-025-07999-4","DOIUrl":"10.1007/s00404-025-07999-4","url":null,"abstract":"<div><h3>Background</h3><p>Endometriosis is one of the most common chronic diseases in women, with a prevalence of up to 10%. The disease particularly affects women of reproductive age. Endometriosis has a significant impact on the patient's quality of life (QoL). In the current study, we aimed to evaluate the role of early diagnosis of endometriosis on patients’ QoL.</p><h3>Methods</h3><p>In this longitudinal prospective study, 205 women with endometriosis who were referred to the gynecology department of Amir al-Mominin Hospital (Zabol-Iran) in 2021 were evaluated. Patients were divided into two groups based on the time of diagnosis, including early diagnosis and late diagnosis. An Endometriosis Health Profile (EHP) questionnaire was used to collect information about QoL before and 18 months after treatment. Data were analyzed using SPSSv.26 software and significance level was considered less than 0.05.</p><h3>Results</h3><p>In both groups with early and late diagnosis, the QoL scores improved without significant difference (<i>p</i> = 0.303). There was a significant difference between lower stages (1 and 2) and higher stages (3 and 4) in terms of treatment effects on patients’ QoL, and higher stages of endometriosis affected patients’ QoL before and after treatment more than lower stages (<i>P</i> values &lt; 0.05).</p><h3>Conclusion</h3><p>Early or late diagnosis of endometriosis doesn’t affect patients’ QoL and patients benefit from treatment regardless of the time of diagnosis.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"311 5","pages":"1415 - 1421"},"PeriodicalIF":2.1,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-025-07999-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cervical injection as an alternative to the utero-ovarian ligament for mapping pelvic sentinel lymph node in early-stage ovarian cancer","authors":"Víctor Lago,&nbsp;Iria Rey,&nbsp;Marta Arnáez,&nbsp;Pablo Padilla-Iserte,&nbsp;Luis Matute,&nbsp;Marta Gurrea,&nbsp;Sara Moner,&nbsp;Pilar Bello,&nbsp;Santiago Domingo","doi":"10.1007/s00404-025-07984-x","DOIUrl":"10.1007/s00404-025-07984-x","url":null,"abstract":"<div><h3>Purpose</h3><p>In early-stage ovarian cancer, sentinel lymph node (SLN) mapping using double injection into the utero-ovarian and infundibulo-pelvic ligaments has been postulated. Cervical injection, commonly used in other gynaecologic tumors, may provide a simpler alternative to utero-ovarian injection for pelvic-SLN detection. This study aims to demonstrate whether cervical and utero-ovarian injections drain to the same pelvic SLN using different tracers for each injection site: technetium-99m (^99mTc) at cervix and indocyanine green into the utero-ovarian ligament.</p><h3>Methods</h3><p>This prospective trial enrolled endometrial cancer patients scheduled for SLN biopsy from July 2023 to May 2024. Each hemipelvis was considered a case. ^99mTc was injected at the cervix preoperatively. If ^99mTc migration occurred, indocyanine green was injected into the utero-ovarian ligament intraoperatively. Concordance of migration was determined in those hemipelvis with both ^99mTc-cervical and indocyanine green utero-ovarian migration.</p><h3>Results</h3><p>Seventeen patients (34 hemipelvis) were included. Migration from both injection sites occurred in 17 hemipelvis, identifying the same pelvic-SLN in all cases, being the concordance rate of 100%. Migration of ^99mTc or indocyanine green from cervical injection was detected in 91.2% (95% CI 81.6–100%), whereas migration of indocyanine green injection from the utero-ovarian ligament was detected in 73.9% (95% CI 56–91.9%); these detection rates were not significantly different (<i>p</i> = 0.077).</p><h3>Conclusions</h3><p>Lymphatic migration from the cervix to the pelvis seems to be comparable to the migration from the utero-ovarian ligament to the pelvis, with both pathways converging at the same SLN.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"311 5","pages":"1407 - 1414"},"PeriodicalIF":2.1,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-025-07984-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thyroid function tests and serum anti-Müllerian hormone in various populations, is there any association? A systematic review and meta-analysis","authors":"Reza Amani-Beni,&nbsp;Bahar Darouei,&nbsp;Sara Ghadimi Nooran,&nbsp;Atiyeh Karimi Shervedani,&nbsp;Nasim Kakavand,&nbsp;Ehsan Amini-Salehi,&nbsp;Seyyed Mohammad Hashemi,&nbsp;Mehrdad Rabiee Rad,&nbsp;Ghazal Ghasempour Dabaghi,&nbsp;Maryam Heidarpour","doi":"10.1007/s00404-025-08015-5","DOIUrl":"10.1007/s00404-025-08015-5","url":null,"abstract":"<div><h3>Purpose</h3><p>This systematic review and meta-analysis aimed to evaluate the association between anti-Müllerian hormone (AMH) as a biomarker of ovarian reserve and various thyroid function tests, including thyroid-stimulating hormone (TSH), free T3 (FT3), free T4 (FT4), T3, T4, and thyroid autoantibodies, such as thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb), in various female populations.</p><h3>Methods</h3><p>A comprehensive literature search was conducted across six electronic databases and original observational studies examining the correlation between AMH levels and at least one TFT, TPOAb, or TgAb.</p><h3>Results</h3><p>Forty studies with 14,009 participants were included in the quantitative synthesis. The pooled results showed that AMH levels were not significantly correlated with TSH levels in the overall population or diverse subgroups. However, after adjusting for publication bias, a small, but significant, positive correlation was observed. Meta-regression analyses identified estradiol, FT3, and follicle-stimulating hormone (FSH) as significant moderators of AMH-TSH association in various populations. AMH was significantly positively correlated with FT3 (r = 0.177) and FT4 (r = 058), negatively correlated with T3 (r = − 0.202) and T4 (r = − 0.216) in the overall population, and significantly positively correlated with TPOAb in the normal population (r = 0.348). AMH levels were not significantly correlated with TgAb levels. Meta-regression revealed body mass index and FT4 as moderators in AMH-FT4 and AMH-TPOAb correlations.</p><h3>Conclusion</h3><p>These findings highlight the complex relationship between AMH and thyroid function markers with potential moderators influencing these associations. Further well-controlled longitudinal studies are required to clarify the underlying mechanisms and clinical implications of these associations across reproductive stages and metabolic profiles.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"311 6","pages":"1489 - 1509"},"PeriodicalIF":2.1,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-025-08015-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The immune-modulatory dynamics of exosomes in preeclampsia","authors":"M. David,&nbsp;N. Maharaj","doi":"10.1007/s00404-025-08013-7","DOIUrl":"10.1007/s00404-025-08013-7","url":null,"abstract":"<div><p>This review delves into the role of exosomes in immune regulation within the context of preeclampsia (PE), a pregnancy condition marked by high blood pressure and widespread inflammation. PE hampers the invasion of trophoblasts and disrupts placental function, contributing to inflammation and maternal organ dysfunction. Exosomes are small extracellular vesicles that mediate cell-to-cell communication by transferring proteins, lipids, and nucleic acids. This review highlights their role in immune regulation during pregnancy, especially their altered behavior in PE. Normally, exosomes support communication between the mother and fetus, promoting immune tolerance. In PE, however, exosomal activity and content undergo significant changes, potentially intensifying the inflammatory state. Further investigation into the in vivo immune-modulatory actions of exosomes, especially those from preeclamptic placentas, may provide insights into the pathogenesis of PE and uncover novel therapeutic targets for treatment.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"311 6","pages":"1477 - 1487"},"PeriodicalIF":2.1,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-025-08013-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}