Archives of Gynecology and Obstetrics最新文献

{"title":"Effect of ethnic origin and newborn gender on mother-infant bonding.","authors":"Hagar Brami, Eyal Sheiner, Tamar Wainstock, Talya Lanxner Battat, Inbal Reuveni, Tom Leibson, Gali Pariente","doi":"10.1007/s00404-025-08003-9","DOIUrl":"https://doi.org/10.1007/s00404-025-08003-9","url":null,"abstract":"<p><strong>Background: </strong>Fetal gender has been shown to influence pregnancy and perinatal outcomes. Adequate mother-infant bonding may have a positive effect on maternal and child's mental health further reducing the risk for maternal depressive symptoms and child's psychopathology.</p><p><strong>Objective: </strong>We aimed to assess the association between newborn gender and mother-infant bonding in the Arab Bedouin women in comparison to the Jewish population residing in the same area.</p><p><strong>Methods: </strong>A cross-sectional study was performed on women who delivered singletons during bonding questionnaire (PBQ). A second analysis of the four sub-scales of the PBQ questionnaire was conducted. The risk for post-partum depression was assessed using the Edinburgh Postnatal Depression Scale (EPDS) questionnaire. Self-reported questionnaires were administered to obtain sociodemographic data and additional information was drawn from women's medical records. Multivariable linear regression models were constructed to control for potential confounders.</p><p><strong>Results: </strong>The final analysis included 218 women, of whom 98 (44.9%) were of Bedouin origin and 120 (55.1%) were of Jewish origin. While total PBQ score was significantly lower among Bedouin women delivering male infants compared to female infants, demonstrating better mother-infant bonding (8.8 ± 3.8 vs. 15.1 ± 9.5, p = 0.010), no difference was found in the total PBQ score between Jewish women delivering male or female infants. Multivariable linear regression models controlling for maternal age, primiparity, and EPDS score demonstrated better mother-infant bonding when delivering a male infant compared to female infant among the Bedouin women (Beta 5.86, 95% CI 1.80-9.90, p = 0.006). Among Jewish women, no independent association was found between infant gender and mother-infant bonding.</p><p><strong>Conclusion: </strong>Better mother-infant bonding was found among Bedouin women delivering male infants compared to females. Modernization is challenging the Bedouins' patriarchal society; therefore, attempts to strengthen mother-infant bonding of the female gender are to be considered.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precision surgery for endometriosis: preventing chronic pelvic pain in patients with higher pre-operative pain scores and in patients of advanced age","authors":"Davit Bokhua,&nbsp;Angela Kather,&nbsp;Anna Kaufmann,&nbsp;Evangelia Polychronaki,&nbsp;Valentina Auletta,&nbsp;Ingo B. Runnebaum","doi":"10.1007/s00404-025-07996-7","DOIUrl":"10.1007/s00404-025-07996-7","url":null,"abstract":"<div><h3>Objective</h3><p>Symptom relief can be achieved for many patients with endometriosis by tailored individual treatment. However, therapy resistance is observed in some patients. This study surveyed patient-reported long-term outcomes after laparoscopic endometriosis surgery and evaluated potential pre-operative predictors for insufficient symptom control.</p><h3>Methods</h3><p>This retrospective study included patients with complete surgical endometriosis resection treated between 2013–2016 at the Department of Gynaecology and Reproductive Medicine, Jena University Hospital. Our 2020 survey gathered socio-demographic, reproductive, symptom-related, and subjective general condition data from 122 patients. Overall pain intensity was assessed using a numeric rating scale (NRS) from zero (no pain) to 100 (highest imaginable pain). Clinical records provided additional information.</p><h3>Results</h3><p>Median time between surgery and interview was 6 years. Postoperatively, the proportion of patients reporting symptoms was considerably reduced (menstrual pain 32.0% vs. 85.2%, chronic pelvic pain [CPP] 40.2% vs. 67.2%, dyspareunia 34.4% vs. 59.8%, hypermenorrhea 17.2% vs. 49.2%; p &lt; 0.001). The majority of respondents (70%) reported improved subjective general condition. Mean NRS Score significantly decreased from 77.2 to 26.6 (p &lt; 0.001). Among pre-operatively infertile women, 45.2% reported successful pregnancies. However, 20–30% of patients did not respond to therapy in one of the analyzed domains. Multivariate logistic regression identified CPP as a strong predictor for failure in permanent pain reduction (OR 5.544, 95% CI 1.338–22.965, p = 0.018) and risk for reoperation (OR 5.191, 95% CI 1.100-24.501, p = 0.038). Higher pre-operative NRS scores and increasing age were associated with better long-term pain relief.</p><h3>Conclusion</h3><p>Patients with higher pre-operative pain scores and patients of advanced age benefit significantly from precision surgery, experiencing sustained symptom relief and improved subjective general condition. However, younger patients with CPP and moderate pre-operative pain intensity showed a higher risk for therapy resistance and require multimodal treatment strategies.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"311 4","pages":"1111 - 1125"},"PeriodicalIF":2.1,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-025-07996-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SARS-CoV-2 infection in pregnant women and incidence of thromboembolic disease: an analysis of the Covid-19-Related Obstetric and Neonatal Outcome Study (CRONOS) in Germany.","authors":"Ulrich Pecks, Michael K Bohlmann, Kristin Andresen, Johanna Büchel, Catharina Bartmann, Magdalena Sitter, Anastasia Tihon, Peter Kranke, Achim Wöckel, Regina Hollweck, Iris Dressler-Steinbach, Susanne Gruessner, Teresa M Gruber, Teresa Eichinger, Jula Manz, Ina M Ruehl, Angela Lihs, Anna-Lena Biermann, Lea M Bauerfeind, Kathleen M Oberste, Babett Ramsauer, Eveline Russe, Susanne Schrey-Petersen, Filiz Markfeld Erol, Cahit Birdir, Lisa Kaup, Gregor Seliger, Christine Morfeld, Martin A Berghaeuser, Manuela F Richter, Peter Jakubowski, Birgit Linnemann, Werner Rath","doi":"10.1007/s00404-025-08007-5","DOIUrl":"https://doi.org/10.1007/s00404-025-08007-5","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of the present study was to quantify the rate of thromboembolic events (TE) in pregnant women with SARS-CoV-2 infection and to characterize risk factors to provide a basis for individualized recommendation on prophylactic measures.</p><p><strong>Methods: </strong>CRONOS is a multicenter, prospective observational study conducted in Germany and Austria during the COVID-19 pandemic. Pregnant women with confirmed SARS-CoV-2 infection were enrolled. Data on demographics, medical history, COVID-19-related aspects, and pregnancy and birth outcomes were collected. TE was particularly queried and used as the primary outcome. A combination of \"TE,\" \"maternal or fetal death,\" or \"severe postpartum hemorrhage\" was defined as a secondary endpoint. Risk analyses were performed using univariate and multivariable logistic regression models.</p><p><strong>Results: </strong>Data from 8033 pregnant patients showed 40 TEs (0.5% incidence). TE rates were 10% in ICU patients, 0.2-0.4% in those with moderate-to-mild COVID-19, and < 0.1% in asymptomatic women. Pulmonary embolism occurred in 21 cases, deep vein thrombosis in 12, and 7 had atypical or arterial TE. Risk factors included advanced gestational age, COVID-19 symptoms, hospitalization or ICU admission, premature birth, cesarean section, delivery within 4 weeks of infection, higher weight gain, anemia, and chronic inflammatory bowel disease. COVID-19 vaccination reduced risk. The logistic risk model yielded an AUC of 0.87 (95% CI 0.81-0.94).</p><p><strong>Conclusion: </strong>The TE rate in pregnant women is largely determined by the severity of the disease. In asymptomatic or mild cases, other factors outweigh TE risk, while severe COVID-19 requiring ICU admission poses a high TE risk despite prophylaxis.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Virtual reality-based pain control in endometriosis: a questionnaire-based pilot study of applications for relaxation and physical activity.","authors":"Viktoria Pakebusch, Barbara Schlisio, Birgitt Schönfisch, Sara Y Brucker, Bernhard Krämer, Jürgen Andress","doi":"10.1007/s00404-025-08000-y","DOIUrl":"https://doi.org/10.1007/s00404-025-08000-y","url":null,"abstract":"<p><strong>Purpose: </strong>Virtual reality (VR) based technology may offer new avenues in the management of chronic endometriosis-related pain. Our prospective, 14-week, open, three-phase, cross-over pilot study investigated whether the use of VR technology equipped with a relaxation-inducing application (VR-R) or an activity-stimulating application (VR-A) could change endometriosis-related chronic pelvic pain levels and impairment of daily life.</p><p><strong>Methods: </strong>23 women aged 32.7 (SD 8.2) with endometriosis-related pelvic pain were each assigned to a permutated sequence of three 4-week phases: (A) the VR-R, (B) VR-A, and (C) intervention-free control phases. Phases were separated by two interspersed 1-week washout phases. Main outcome measures included: momentary, average, and maximum pain intensities on a 0-10 numerical rating scale (NRS); the Pain Disability Index (PDI) score; the Pain Catastrophizing Scale (PCS) score; sleep quality (Medical Outcomes Study Sleep Scale (MOS-SS) score); the Depression Anxiety Stress Scales (DASS) score; and the general health-related quality-of-life score (Short Form (12) Health Survey (SF-12)).</p><p><strong>Results: </strong>Compared to baseline, VR-R use showed statistically significant positive effects for several scores (NRS \"average pain\"; PDI \"total score\"; PCS \"total score\" and the \"magnification\", \"rumination\", and \"helplessness\" subscores; MOSS-SS \"index I and II\"; and the DASS \"depression\" and \"stress\" subscores), whereas VR-A yielded significant positive changes only for PDI \"total score\"; PCS \"total score\" and the \"helplessness\" and \"magnification\" subscores; MOSS-SS \"index II\"; and DASS \"depression\" and \"stress\". As four scale scores also showed significant improvements for control, a comparison of the effects was performed to offset a potential placebo-like effect by comparing difference from baseline against control. This analysis yielded significantly greater positive effects only for VR-R: PCS \"total score\" and \"helplessness\"; MOSS-SS \"index I\" and \"index II\"; and the three DASS subscores \"depression\", \"anxiety\", and \"stress\". SF-12 showed no significant changes in either analysis.</p><p><strong>Conclusions: </strong>VR-R and VR-A showed positive effects on several pain and quality-of-life scores, which were significant for some scores compared to baseline. For VR-R, some of these improvements were indeed significantly greater than under control conditions, while the effects with VR-A were not. Larger studies are needed to corroborate these findings.</p><p><strong>Trial registration: </strong>DRKS00030189.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of nitric oxide donor and plasma volume expansion on pregnancies with early onset fetal growth restriction: a randomized controlled trial.","authors":"Maya Mahmoud Abdelrazek, Mai Abdelfattah Ahmed, Mohamed Elmandooh Mohamed Ibrahim","doi":"10.1007/s00404-025-07988-7","DOIUrl":"https://doi.org/10.1007/s00404-025-07988-7","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effect of nitric oxide (NO) donor, in combination with plasma volume expansion, on both fetal and maternal outcomes in pregnancies complicated by early-onset fetal growth restriction (FGR).</p><p><strong>Methods: </strong>A total of 40 pregnant women diagnosed with early onset FGR were recruited from Ain Shams University Maternity Hospital between June 2023 to December 2023. The patients were randomly assigned into two groups, 20 in each group. Group A received Nitroderm TTS ^® 5 mg for 12 h daily with plasma volume expansion (PVE) in the form of 2.5 L of water per day. Group B represented the control group. The primary endpoint of the study, assessed after 2 weeks of treatment initiation, focused on fetal growth parameters as the primary outcome. In addition, amniotic fluid volume, umbilical artery Doppler changes, development of fetal complications, maternal vital signs, and any side effects, were recorded. At the time of delivery, the following also documented: timing, mode, and interval to delivery, along with neonatal outcomes.</p><p><strong>Results: </strong>Group A exhibit statistically significant enhancement in fetal growth compared to Group B in terms of estimated fetal weight, abdominal circumference, head circumference, biparietal diameter, femur length, amniotic fluid volume, and umbilical artery pulsatility index. Furthermore, Group A demonstrated more favorable outcomes in terms of gestational age at delivery, interval to delivery, birth weight, APGAR score and rates of NICU admission.</p><p><strong>Conclusion: </strong>The combination of NO donors and PVE has shown promising results in enhancing fetal growth and extending gestation. This study adds to the existing body of evidence supporting the effectiveness of NO donor therapy when used in conjunction with fluid management for managing FGR. Nonetheless, additional research is essential to validate these results and refine the treatment strategy for optimal outcomes in affected pregnancies.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"T-shaped dysmorphic uterus: discrepancies between current 3D-ultrasound diagnostic criteria.","authors":"Giulia Monaco, Elvira Nocita, Aikaterini Selntigia, Consuelo Russo, Daniele Farsetti, Sabrina Reppuccia, Carlo De Angelis, Brunella Zizolfi, Attilio Di Spiezio Sardo, Caterina Exacoustos","doi":"10.1007/s00404-025-07986-9","DOIUrl":"https://doi.org/10.1007/s00404-025-07986-9","url":null,"abstract":"<p><strong>Purpose: </strong>Review and compare current classifications for diagnosing T-shaped uterus using three-dimensional transvaginal ultrasound (3D-TVS) measurements, identifying measurements that best correlate with the diagnosis.</p><p><strong>Methods: </strong>This retrospective cohort study analyzed diagnostic measurements in patients with T-shaped uterus who underwent 3D-TVS at the University of Rome 'Tor Vergata' from 2016 to 2022. Of 7588 patients, four sonographers re-evaluated 3D-TVS images of 72 initially diagnosed cases. Uterine morphology was assessed in the coronal plane by measuring fundal cavity width (R0), corpus-isthmic cavity width (Wi), lateral indentation angle (AI), lateral bulging (LB), T-angle (AT), fundal/isthmic cavity width ratio (R0/Wi), and the length of intracavitary line parallel to interostial line (R10). All cases were confirmed by hysteroscopy, excluding ambiguous findings.</p><p><strong>Results: </strong>Of 72 initially evaluated patients, 50 met the inclusion criteria for final analysis. These patients had consistent 3D-TVS diagnoses from four sonographers and hysteroscopic confirmation from two experts. The combination of three CUME criteria (AT ≤ 40°, AI ≤ 130°, LB ≥ 7 mm) identified only 8% of T-shaped uteri. Notably, 30 patients (60%) had an R10 measurement of ≤ 10 mm. In addition, 31 uteri (62%) met all three criteria: LB ≥ 5 mm, AI ≤ 140°, and R0/Wi ≥ 5. Overall, 48 uteri (96%) satisfied at least two criteria. The study concluded that LB, R10, and R0/Wi are independent predictors of T-shaped uterus.</p><p><strong>Conclusions: </strong>Significant discrepancies exist among current classifications for diagnosing T-shaped uterus. This study identified LB, R10, and R0/Wi as key parameters for accurate diagnosis. These measurements provide a precise and objective approach, aiding in the evaluation of the anomaly's impact on reproductive outcomes and the benefits of hysteroscopic treatment.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perinatal outcomes of twin pregnancies in women with a unicornuate uterus.","authors":"Si Wang, Qing Hu, Hua Liao, Haiyan Yu","doi":"10.1007/s00404-025-08001-x","DOIUrl":"https://doi.org/10.1007/s00404-025-08001-x","url":null,"abstract":"<p><strong>Objective: </strong>A unicornuate uterus is a type of Müllerian anomaly and is associated with adverse pregnancy outcomes. However, the perinatal outcomes of twin pregnancies in women with a unicornuate uterus remain unknown, and previous studies on women with a unicornuate uterus have focused mostly on those with singleton pregnancies. This research aimed to investigate the perinatal outcomes of twin pregnancies in women with a unicornuate uterus.</p><p><strong>Methods: </strong>From January 2013 to December 2022, 283 women with a unicornuate uterus, including 21 with twin pregnancies (Group A), 262 with singleton pregnancies (Group B), and 105 with twin pregnancies and a normal uterus (Group C) were enrolled in this study and gave birth at West China Second University Hospital, Sichuan University. General characteristics and perinatal outcomes were retrospectively analysed using SPSS version 22.0.</p><p><strong>Results: </strong>Among the 21 women with twin pregnancies and a unicornuate uterus, 20 (95.2%) had dichorionic diamniotic twins, and 1 (4.8%) had monochorionic diamniotic twins. Seventeen patients (81.0%) conceived by in vitro fertilization-embryo transfer (IVF-ET), and 4 patients (19.0%) conceived naturally. The mean gestational age at delivery was 33.8 ± 5.7 weeks, and 19 patients (90.5%) underwent caesarean section. The twin group (A) had significantly higher rates of preterm premature rupture of membranes (38.1%, 8/21), preterm delivery (85.7%, 18/21) (preterm delivery was defined as a birth occurring after 28 weeks and before 37 completed weeks of gestation), and neonatal intensive care unit (64.3%, 27/42) admission than Groups B and C (p < 0.05). Moreover, the live birth weight in Group A (1931.7 ± 535.2 g) was lower than that in Groups B and C (p < 0.001).</p><p><strong>Conclusion: </strong>The incidence of complications and the risk of adverse perinatal outcomes in women with twin pregnancies and a unicornuate uterus are greater than those in women with singleton pregnancies and a unicornuate uterus and women with twin pregnancies and a normal uterus. Thus, maternal and foetal monitoring during pregnancy should be strengthened to achieve good outcomes.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of autologous platelet-rich plasma intrauterine perfusion on clinical outcomes in recurrent implantation failure patients with non-thin endometrium undergoing frozen-thawed embryo transfer.","authors":"Xiao-Hui Liu, Li-Xia He, Man Li, Zheng-Ping Tian, An-Qi Qin, Jun Yao","doi":"10.1007/s00404-025-07983-y","DOIUrl":"https://doi.org/10.1007/s00404-025-07983-y","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the effects of autologous platelet-rich plasma (PRP) intrauterine perfusion on clinical outcomes in recurrent implantation failure (RIF) patients with non-thin endometrium undergoing frozen-thawed embryo transfer (FET), and the effects of PRP used at different times before FET on clinical outcomes.</p><p><strong>Methods: </strong>A total of 160 RIF patients with non-thin endometrium undergoing FET were retrospectively analyzed. Among them, 82 patients received PRP intrauterine perfusion at 24-72 h before FET (PRP group), and 78 patients did not (non-PRP group). In PRP group, 59 patients underwent PRP at 24-48 h before FET (≥ 24 to  ≤ 48 h group), and 23 patients was at 48-72 h (> 48 to  ≤ 72 h group). The clinical outcomes were compared, including β-hCG positive rate, clinical pregnancy rate, embryo implantation rate, abortion rate, ectopic pregnancy rate, live birth rate and the incidence of adverse events.</p><p><strong>Results: </strong>The clinical pregnancy rate, embryo implantation rate and live birth rate in PRP group were significantly higher than those in non-PRP group (P < 0.05), and there were no statistical differences in β-hCG rate, abortion rate and ectopic pregnancy rate between the two groups (P > 0.05). Meanwhile, there was no adverse events occurred in PRP group. However, the C-type endometrium rate in PRP group was observably higher on FET day (Χ² = 8.309, P = 0.004), though there was no statistical difference in endometrial thickness (P > 0.05). The multiple logistics regression analysis showed that PRP intrauterine perfusion are closely related with clinical pregnancy and live birth in RIF patients with non-thin endometrium (OR: 2.379, 95% CI 1.137-4.977, P = 0.021; OR: 2.107, 95% CI 1.006-4.412, P = 0.048). Moreover, we found no significant difference in clinical outcomes between the two groups of PRP intrauterine perfusion at ≥ 24 to ≤ 48 h and > 48 to ≤ 72 h before FET (P > 0.05), except for β-hCG positive rate.</p><p><strong>Conclusions: </strong>PRP intrauterine perfusion can safely and effectively improve the clinical pregnancy rate, implantation rate and live birth rate in RIF patients with non-thin endometrium possibly by increasing the C-type endometrium rate on FET day. In addition, PRP intrauterine perfusion at different times of 24-72 h before FET does not affect the clinical outcomes, which will be helpful to guide clinical work flexibly.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The \"popcorn\" sign: the first early ultrasound sign of serous intra-parenchymal ovarian cancer in BRCA mutation carriers.","authors":"Giovanni Grandi, Alice Sgandurra, Laura Cortesi, Angela Toss, Massimo Dominici, Valentina Grisendi, Valeria Pedrini, Laura Botticelli, Antonio La Marca","doi":"10.1007/s00404-025-08010-w","DOIUrl":"https://doi.org/10.1007/s00404-025-08010-w","url":null,"abstract":"","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value of CODAC classification in identifying causes of stillbirths.","authors":"Karima Mekni, Hyem Khiari, Ameni Tissaoui, Khaoula Belaid, Imène Habassi, Chiraz Elfekih","doi":"10.1007/s00404-025-07955-2","DOIUrl":"https://doi.org/10.1007/s00404-025-07955-2","url":null,"abstract":"<p><strong>Purpose: </strong>Stillbirth is a public health problem and one of the main obstetrical complications of pregnancy that practitioners can ever witness. A careful etiological investigation and a search for risk factors is necessary. The main objective of our study was to identify the causes of stillbirths using the CODAC classification system.</p><p><strong>Methods: </strong>It was a monocentric retrospective descriptive study conducted over 5 years in our gynecology department. We collected 114 cases.</p><p><strong>Results: </strong>The overall frequency was 8.26 ‰. The average age of women was 32.19 years. Women came from an urban environment in 48.2% and had a low level of education in 54.4% of cases. Our patients were moderately obese (48%). A history of stillbirth was found in 33 cases (28.9%), and the average term of pregnancy was 32 weeks' gestation. Pregnancy was poorly monitored in 2/3 of the population studied. The most frequent reason for consultation was a decrease/absence of fetal movement perception (30%). Labor was induced in 53.5% of deliveries. Delivery was by vaginal route in 58% of cases and the male sex was predominant (61%). For funicular anomalies, a placental abruption was found in 21.1% of cases, and a cord loop in 11.4%. For the etiological investigation via the CODAC classification, maternal pathologies were the most frequent with 28.07% of cases dominated by hypertension. Placental pathologies (placental abruption) and cord abnormalities (cord loop) represented, respectively, 22 and 21.05%. An unexplained cause was found in 20.17%.</p><p><strong>Conclusions: </strong>For the etiological investigation, we relied on the CODAC classification to minimize unexplained causes. This etiological investigation is essential not only to provide answers for the bereaved couple but also to prevent the recurrence of such incidents in subsequent pregnancies.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}