Archives of Gynecology and Obstetrics最新文献

{"title":"Predictors of quality of life and resilience in patients with ovarian cancer during the COVID-19 pandemic: a cross-sectional study.","authors":"Larissa Schilling, Anne Toussaint, Angelika Weigel, Dorothea Lewitz, Golo Aust, Jeanne Töllner, Gülten Oskay-Özcelik, Annette Hasenburg, Bernd Löwe, Barbara Schmalfeldt","doi":"10.1007/s00404-024-07870-y","DOIUrl":"https://doi.org/10.1007/s00404-024-07870-y","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this cross-sectional study was to investigate the psychosocial burdens of patients with ovarian cancer during the COVID-19 pandemic.</p><p><strong>Methods: </strong>Ovarian cancer patients answered a quantitative survey assessing their resilience (BRS) and quality of life (FACT-G7) as well as clinical (first- vs. ≥ second-line treatment), demographic (age < 65 vs. ≥ 65 years) and COVID-19 pandemic-related psychosocial impairment, i.e. anxiety (GAD7); depression (PHQ2); global physical, mental, and social health (PROMIS items). Analyses of variance were applied to compare psychological impairment between patients on first- vs. ≥ second-line treatment and between patients aged < vs. ≥ 65 years at start of treatment. Multiple linear regression analyses were performed to evaluate predictors of patients' resilience and quality of life based on demographic, clinical, and psychosocial variables.</p><p><strong>Results: </strong>Most of the 93 patients rated their physical and mental health, and satisfaction with social activities as good. Eighty-seven (91.4%) were somewhat or very concerned about the pandemic. Patients on first-line therapy reported a better quality of life (p = 0.03) and better general health (p = 0.014) than those on at least second-line therapy. Patients < 65 years old reported significantly more concern about the pandemic than older patients (p = 0.008). Predictors of resilience were severity of anxiety (GAD-7) and mental health. Predictors of quality of life were general health, severity of depression (PHQ-2), and type of therapy.</p><p><strong>Conclusions: </strong>Patients in first line of treatment and younger patients could benefit from support in coping with pandemic-related burdens, meaning that attention should be paid to potential psychological distress, which should be treated alongside the cancer.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142833812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting recurrence in adult granulosa cell tumors: the role of Ki67, p53, and TERT mutations.","authors":"Aysel Bayram, Sidar Bagbudar, İsmail Yılmaz, Hamdullah Sozen, Yağmur Minareci, Ali Yılmaz Altay, Sabire Aslı Altunbas, Ekrem Yavuz, Semen Onder","doi":"10.1007/s00404-024-07888-2","DOIUrl":"https://doi.org/10.1007/s00404-024-07888-2","url":null,"abstract":"<p><strong>Purpose: </strong>Adult granulosa cell tumors (aGCTs) are a rare type of ovarian malignancy. While most aGCTs have an indolent course, up to 25% experience recurrence. Identifying markers for disease recurrence is crucial for optimal management.</p><p><strong>Methods: </strong>Our study consisted of a total of 55 patients, comprising primary non-recurrent aGCTs (n = 30), aGCT recurrences without corresponding primary tumors (n = 19), and primary aGCTs which later recurred along with their matched recurrences (n = 6). Immunohistochemical analysis was conducted for CD73, Ki67, and p53, along with TERT mutation analysis on selected tissue samples.</p><p><strong>Results: </strong>Immunohistochemical analysis revealed higher Ki67 proliferation index in recurrent aGCTs compared to non-recurrent cases. Mutational p53 staining was only present in recurrent cases. CD73 expression did not differ significantly between primary non-recurrent and recurrent aGCTs. A notably increased occurrence of TERT promoter mutations was identified in recurrent aGCTs (14/25, 56%) in contrast to primary non-recurrent instances (8/27, 29.6%) (p = 0.05). In primary non-recurrent aGCTs with identified TERT mutations, the C250T locus was impacted in 2 cases, while the C228T locus was affected in 6 cases. Recurrent aGCT cases predominantly exhibited TERT C228T mutation in 13 out of 14 patients. Among the six pairs of primary and recurrent aGCTs studied, four pairs displayed TERT mutations in both primary and recurrence samples. Moreover, cases with TERT mutations exhibited a higher Ki67 index.</p><p><strong>Conclusion: </strong>Identifying patients with high Ki67 and mutational p53 together with TERT mutations may help predict potential recurrence in aGCT cases.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142833811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current surgical treatment of uterine isthmocele: an update of existing literature.","authors":"Konstantinos Stavridis, Dimitrios Balafoutas, Nikos Vlahos, Ralf Joukhadar","doi":"10.1007/s00404-024-07880-w","DOIUrl":"https://doi.org/10.1007/s00404-024-07880-w","url":null,"abstract":"<p><p>The prevalence of uterine isthmocele, also known as a uterine niche, has risen in parallel with increasing cesarean section (CS) rates, affecting approximately 60% of women depending on their history of cesarean deliveries. This condition, now categorized as cesarean scar disorder (CSD) by the \"Delphi consensus,\" is characterized by one primary or two secondary symptoms. Diagnosis can be made through transvaginal ultrasound, sonohysterography, hysteroscopy, or magnetic resonance imaging (MRI). Management of isthmocele may involve pharmacological or surgical interventions. This review aims to provide a thorough analysis of the surgical management options, focusing on postoperative symptom relief, intraoperative and postoperative complications, length of hospital stay, and impact on secondary infertility. PubMed was comprehensively searched for observational studies from inception to 07.08.2024. Surgical treatments include hysteroscopic resection, laparoscopic procedures, and vaginal approaches, all of which offer comparable symptom relief. However, the vaginal approach is associated with a longer hospital stay. The robotic-assisted approach shows promising results but lacks extensive data. Among surgical options, hysteroscopic treatment has the fewest complications but is generally avoided when residual myometrial thickness (RMT) is less than 3 mm. While many CSDs remain asymptomatic, and some women with uterine isthmocele may not wish to conceive, symptomatic patients or those desiring to conceive may benefit from surgical intervention. The choice of procedure should be based on individual patient characteristics, particularly RMT, to define the most appropriate surgical approach.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to balance the live birth rate and the multiple pregnancy rate by selecting the cleavage-stage embryo number and quality for POSEIDON Group 1 and Group 2? A retrospective study.","authors":"Huiqing He, Rang Liu, Qiuju Zhang, Lan Geng, Zhenhui Hou, Chang Xu, Yanpei Cao, Xi Xia","doi":"10.1007/s00404-024-07850-2","DOIUrl":"https://doi.org/10.1007/s00404-024-07850-2","url":null,"abstract":"<p><strong>Purpose: </strong>For unexpected low-prognosis patients (Group 1 and Group 2) defined by POSEIDON criteria, how to maximize the live birth rate while controlling the multiple birth rate by tailoring the embryo transfer number and quality?</p><p><strong>Methods: </strong>This was a retrospective study, including patients from Poseidon Group 1 (N = 672) and Group 2 (N = 503) who underwent cleavage-stage embryo transfer. Logistic regression was used for the comparative analysis of clinical outcomes among subgroups divided by the number and quality of embryos.</p><p><strong>Results: </strong>For Group 1, compared to transferring a single good-quality embryo (GQE), a good-quality embryo with a poor-quality embryo (GQE + PQE) did not significantly improve the live birth rate, although increasing in value (40.5% vs 31.9%, P = 0.272), meanwhile obviously raised the multiple birth rate to 28.1% (P = 0.042). For Group 2, double embryo transfer (DET) was associated with a higher live birth rate than single embryo transfer (SET) (22.4% vs 6.3%, P = 0.001) and further analysis indicated that the similar trend observed in the GQE + PQE group compared to the GQE group (26.1% vs 8.5%, P = 0.017) with statistical significance, but without a significant increase in the multiple birth rate (8.3%, P = 1.000).</p><p><strong>Conclusions: </strong>The study indicated that  a single good-quality cleavage-stage embryo was an option for patients in Poseidon Group 1 to avoid the risk of multiple pregnancies. DET with mixed quality cleavage-stage embryo might be an alternative for Poseidon Group 2, given that it improved the pregnancy outcomes while controlling the multiple birth rates.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary cytoreductive surgery in platinum-sensitive relapsed ovarian cancer: a meta-analysis of randomized controlled trials.","authors":"Qingqing Lin, Wenchao Liu, Yanglong Guo, Xinyu Wang","doi":"10.1007/s00404-024-07863-x","DOIUrl":"https://doi.org/10.1007/s00404-024-07863-x","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the role of secondary cytoreduction in patients with platinum-sensitive recurrent ovarian cancer.</p><p><strong>Methods: </strong>The PubMed, Medline, Embase, Cochrane Library and Web of Science databases were searched. Randomized controlled trials (RCTs) that compare secondary cytoreduction plus chemotherapy with chemotherapy alone in patients with platinum-sensitive relapsed ovarian cancer were selected. Pooled hazard ratios (HR) with 95% confidence intervals (CIs) were calculated.</p><p><strong>Results: </strong>There was no difference in overall survival (OS) between the surgery group and no surgery group (HR = 0.89; 95% CI 0.77, 1.04; p = 0.14), but secondary cytoreduction showed a significant improvement in progression-free survival (PFS) (HR = 0.67; 95% CI 0.54, 0.76; p < 0.00001). A subgroup analysis comparing the complete gross resection subpopulation with the no surgery group achieved a significant longer OS (HR = 0.70, 95% CI 0.58-0.85; p = 0.0003) and a greater PFS benefit (HR = 0.56, 95% CI 0.48-0.66; p < 0.00001). In addition, as compared with incomplete resection, the OS benefit of complete gross resection was more evident (HR = 0.51, 95% CI 0.37-0.69; p < 0.0001).</p><p><strong>Conclusions: </strong>In women with platinum-sensitive recurrent ovarian cancer, although secondary cytoreduction followed by chemotherapy resulted in longer PFS than chemotherapy alone, it did not lead to significant benefit in OS. However, when complete gross resection was achieved, it significantly prolonged OS and provided a greater PFS benefit.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prognostic influence of hospital type, method of first histological confirmation and time to chemotherapy in patients with advanced primary ovarian cancer.","authors":"Olivia Starke, Pauline Wimberger, Daniel Martin Klotz","doi":"10.1007/s00404-024-07832-4","DOIUrl":"https://doi.org/10.1007/s00404-024-07832-4","url":null,"abstract":"<p><strong>Purpose: </strong>Ovarian cancer is the fifth most common cancer in women and the leading cause of death of all gynecological malignancies. Prognosis is determined by optimal surgical outcome (macroscopic complete resection) most commonly achieved in tertiary hospitals. We investigated whether tertiary versus non-tertiary hospital as the location of an initial diagnostic intervention for histological confirmation before cytoreductive surgery versus immediate primary debulking surgery impacts outcome in patients with advanced ovarian cancer.</p><p><strong>Methods: </strong>We analyzed 115 patients who underwent cytoreductive surgery at a German tertiary center: 60 patients underwent primary debulking surgery (PDS) and 55 patients had a diagnostic intervention for histological confirmation before debulking surgery (PHC).</p><p><strong>Results: </strong>Although there was no prognostic difference between the two subgroups, the median time to chemotherapy was longer in the PHC group (46 days) compared to the PDS group (26 days; p < 0.0001), equally seen comparing non-tertiary versus tertiary PHC groups (p: 0.0001), its impact confirmed in a multivariate analysis (PFS: HR: 1.03, 95%CI: 1.01-1.05, p: 0.007; OS: HR: 1.04, 95%CI: 1.02 -1.06, p: < 0.001) of the PHC group only. In total, 9/10 patients with port-site metastases after diagnostic laparoscopy were initially treated at non-tertiary hospitals, resulting in a lower PFS compared to patients without port-site metastases after laparoscopy (HR 0.21, 95%CI 0.06-0.733, p: 0.014).</p><p><strong>Conclusions: </strong>In conclusion, patients with ovarian cancer undergoing treatment solely at a tertiary center have some clinical benefits and improved outcome, given the shorter time to chemotherapy and potential impact of port-site metastases. This supports centralization of oncological treatment.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age at menarche and risk of premature coronary artery disease: results from Iran premature coronary disease (IPAD) study.","authors":"Ghazal Ghasempour Dabaghi, Ali Pourmoghaddas, Mehrdad Rabiee Rad, Ehsan Zarepur, Noushin Mohammadifard, Nahid Azdaki, Nahid Salehi, Kamal Solati, Samad Ghaffari, Arsalan Salari, Ahmadreza Assareh, Niloufar Shabani, Nizal Sarrafzadegan","doi":"10.1007/s00404-024-07860-0","DOIUrl":"https://doi.org/10.1007/s00404-024-07860-0","url":null,"abstract":"<p><strong>Background: </strong>Premature coronary artery diseases (PCAD) is a major health concern. Finding the potential risk factors for this health issue is crucial for early detection and prevention. This study aimed to evaluate the relation between age at menarche and PCAD presence and severity.</p><p><strong>Methods: </strong>This study was performed in the framework of the Iran premature coronary disease (IPAD). IPAD is a multiethnic case-control study conducted from 2020. PCAD was defined as at least 75% obstruction in more than one coronary artery or above 50% in the left main artery in man and women under the age of 60 years and 70 years, respectively. Age at menarche is evaluate using self-reporting questionnaire. We categorized age at menarche into three groups: early (8-11 years), average (12-13 years), and late (14-17 years).</p><p><strong>Results: </strong>A total number of 1035 women participated in this study. No significant association was observed between every year increase in age at menarche and the PCAD risk after fully adjustment with odds ratio (OR) 95% confidence interval (95% CI) OR = 0.98, 95% CI 0.91-1.05, P = 0.65 Besides, no significant association was seen between number of obstructed vessels and age at menarche (OR = 1.01; 95% CI 0.94-1.08, P = 0.76). Following the subgroup analysis based on ethnicity, it was observed that only individuals of Gilak ethnicity showed a significant association between a 1-year increase in age at menarche and the risk of PCAD (OR = 0.68, 95% CI 0.49-0.95, P = 0.026).</p><p><strong>Conclusion: </strong>This study suggested that age at menarche may not be connected to PCAD risk and number of obstructed vessels. However, ethnicity may have roles in terms of the relationship between age at menarche and PCAD. More longitudinal studies are needed to evaluate this relationship.</p><p><strong>Trial registration number: </strong>IR.MUI.REC.1396.2.055.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of hysteroscopic adhesiolysis with electrosurgery instrument or hysteroscopic scissors in the treatment of intrauterine adhesions of infertile or recurrent pregnancy loss women.","authors":"Yang Li, Yangzhi Li, Yong Wang, Minzhi Hou, Xing Yan, Dongmei Chen, Yaxiao Chen, Meiqing Xie","doi":"10.1007/s00404-024-07866-8","DOIUrl":"https://doi.org/10.1007/s00404-024-07866-8","url":null,"abstract":"<p><strong>Objective: </strong>To investigate pregnancy outcomes following hysteroscopic adhesiolysis (HA) in patients with recurrent pregnancy loss (RPL) or infertility.</p><p><strong>Design: </strong>Retrospective cohort study.</p><p><strong>Setting: </strong>University-affiliated hospital.</p><p><strong>Subjects: </strong>According to the inclusion and exclusion criteria of this study, finally, a total of 461 subjects were included.</p><p><strong>Interventions: </strong>HA performed using either an electrosurgical instrument or hysteroscopic scissors.</p><p><strong>Main outcome measures: </strong>Pregnancy outcomes post-HA.</p><p><strong>Results: </strong>A total of 461 patients were included in the study, with follow-up periods ranging from 1 to 6 years. The mean age was 29.48 ± 3.25 years. Hysteroscopic scissors demonstrated greater efficiency in restoring the uterine cavity compared to electrosurgical instruments (88.1% vs. 80.0%, p = 0.025). Post-HA, the pregnancy rate was approximately 75.3% (347/461), with a live birth rate of 55.9% (251/449). No significant differences were found between the electrosurgical instrument and hysteroscopic scissors groups regarding improvements in menstrual flow or fertility outcomes (all p > 0.05). Kaplan-Meier time-dependent cumulative curves for pregnancy and live birth rates after HA indicated that over 50% of patients achieved pregnancy within one year, with the pregnancy rate plateauing at 2 years and the live birth rate at 3 years.</p><p><strong>Conclusion: </strong>Our findings suggest that HA can improve fertility outcomes for patients with RPL or infertility within 2 to 3 years following surgery. Hysteroscopic scissors proved more effective than electrosurgical instruments in restoring the uterine cavity, although no differences were observed between the techniques in terms of menstrual flow or fertility improvements. All in all, our study suggests that standardized HA procedures, the implementation of proactive intraoperative and postoperative measures to prevent the recurrence of intrauterine adhesions (IUA), and an active conception plan following HA are key factors in improving reproductive outcomes for these patients with RPL or infertility.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting the risk of cesarean hysterectomy in the management of placenta accreta spectrum disorders: a new model based on clinical findings and ultrasonography.","authors":"İbrahim Taşkum, Furkan Çetin, Seyhun Sucu, Muhammed Hanifi Bademkıran, Özge Kömürcü Karuserci, Cihan Bademkıran, Hüseyin Çağlayan Özcan","doi":"10.1007/s00404-024-07858-8","DOIUrl":"https://doi.org/10.1007/s00404-024-07858-8","url":null,"abstract":"<p><strong>Purpose: </strong>To develop a nomogram to predict the probability of cesarean hysterectomy (CH) in placenta accreta spectrum disorders (PASD) patients.</p><p><strong>Methods: </strong>Data from 520 patients who underwent surgery with a preliminary diagnosis of PASD at a tertiary center in southeast Turkey between 2013 and 2023 were collected, and 302 patients were included in the study. A predictive model based on clinical and ultrasonographic variables was developed using penalized maximum likelihood estimation (PMLE) regression analysis.</p><p><strong>Results: </strong>Maternal age (aOR = 1.22, 95% CI 1.08-1.44, p = 0.001) and prior uterine surgeries (aOR = 3.18, 95% CI 1.57-8.29, p = 0.001) were identified as demographic factors with an increased likelihood of CH in the nomogram, and advanced gestational weeks demonstrated a negative correlation (aOR: 0.78, 95% CI 0.56-1.02, p = 0.07). Regarding the ultrasonographic findings, the presence of the \"multiple lacunae within the placenta\" (aOR = 48.53, 95% CI 18.42-257.40, p < 0.001) and the \"anterior placental location\" (aOR = 9.60, 95% CI 2.96-50.76, p < 0.001) significantly increased the probability of CH. In addition, \"hypervascularization on Doppler flow with irregularity in the line between the bladder and uterine serosa\" (aOR = 7.90, 95% CI 2.66-35.12, p < 0.001) and the \"retroplacental myometrial thickness of < 1 mm\" (aOR = 2.49, 95% CI 0.89-8.27, p = 0.08) were related to the probability of CH. Harrell's C-index was 0.974, and the kappa value was 0.819 for the prediction model's performance evaluation.</p><p><strong>Conclusion: </strong>We developed a nomogram to predict the probability of cesarean hysterectomy in patients with PASD, incorporating maternal age, gestational weeks, prior uterine surgeries, ultrasound findings, and placental location. The most closely associated findings with CH in patients with PASD were the presence of multiple placental lacunae and the anterior location of the placenta.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is work burden associated with postmenopausal breast cancer? A population-based 25-year follow-up.","authors":"Maria Kalliosaari, T Rikkonen, R Sund, M Tuppurainen","doi":"10.1007/s00404-024-07867-7","DOIUrl":"https://doi.org/10.1007/s00404-024-07867-7","url":null,"abstract":"<p><strong>Objective: </strong>To study the association between breast cancer and work burden over 25 years.</p><p><strong>Methods: </strong>The study was based on the Kuopio Osteoporosis Risk Factor and Prevention (OSTPRE) cohort (n = 14,220) and included women who had answered the questionnaire from the year 1994 and had no previous breast cancer. Breast cancer cases were recorded from the Finnish Cancer Registry during the study period: from 1st June 1994 till December 31, 2019. Using questionnaires, we collected information on work burden, body mass index (BMI), menopausal hormone therapy (MHT), alcohol consumption, parity, and family history of breast cancer. Work burden was categorized as low or high. Variables were used both in the univariate and multivariate Cox regression analyses to explore their associations with breast cancer.</p><p><strong>Results: </strong>Altogether 825 women (6.9%) were diagnosed with breast cancer during the study period with a mean follow-up of 13.3 ± 7.2 years. Women with breast cancer were compared to those without breast cancer during the follow-up period (n = 11,117). A low work burden was associated with a 1.3-fold higher incidence of breast cancer (95% confidence interval 1.2-1.6) than a high work burden. Low work burden was associated with an increased breast cancer risk.</p><p><strong>Conclusion: </strong>Low work burden is associated with elevated postmenopausal breast cancer risk in the 25-year follow-up period.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142811987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}