Archives of Gynecology and Obstetrics最新文献

{"title":"Effect of ethnic origin and newborn gender on mother-infant bonding.","authors":"Hagar Brami, Eyal Sheiner, Tamar Wainstock, Talya Lanxner Battat, Inbal Reuveni, Tom Leibson, Gali Pariente","doi":"10.1007/s00404-025-08003-9","DOIUrl":"10.1007/s00404-025-08003-9","url":null,"abstract":"<p><strong>Background: </strong>Fetal gender has been shown to influence pregnancy and perinatal outcomes. Adequate mother-infant bonding may have a positive effect on maternal and child's mental health further reducing the risk for maternal depressive symptoms and child's psychopathology.</p><p><strong>Objective: </strong>We aimed to assess the association between newborn gender and mother-infant bonding in the Arab Bedouin women in comparison to the Jewish population residing in the same area.</p><p><strong>Methods: </strong>A cross-sectional study was performed on women who delivered singletons during bonding questionnaire (PBQ). A second analysis of the four sub-scales of the PBQ questionnaire was conducted. The risk for post-partum depression was assessed using the Edinburgh Postnatal Depression Scale (EPDS) questionnaire. Self-reported questionnaires were administered to obtain sociodemographic data and additional information was drawn from women's medical records. Multivariable linear regression models were constructed to control for potential confounders.</p><p><strong>Results: </strong>The final analysis included 218 women, of whom 98 (44.9%) were of Bedouin origin and 120 (55.1%) were of Jewish origin. While total PBQ score was significantly lower among Bedouin women delivering male infants compared to female infants, demonstrating better mother-infant bonding (8.8 ± 3.8 vs. 15.1 ± 9.5, p = 0.010), no difference was found in the total PBQ score between Jewish women delivering male or female infants. Multivariable linear regression models controlling for maternal age, primiparity, and EPDS score demonstrated better mother-infant bonding when delivering a male infant compared to female infant among the Bedouin women (Beta 5.86, 95% CI 1.80-9.90, p = 0.006). Among Jewish women, no independent association was found between infant gender and mother-infant bonding.</p><p><strong>Conclusion: </strong>Better mother-infant bonding was found among Bedouin women delivering male infants compared to females. Modernization is challenging the Bedouins' patriarchal society; therefore, attempts to strengthen mother-infant bonding of the female gender are to be considered.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":"237-245"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12176941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there an association between lateral uterine localization of the placenta and pregnancy outcomes?","authors":"Hanoch Schreiber, Gal Cohen, Ofer Markovitch, Omer Weitzner, Sivan Farladansky-Gershnabel, Tal Biron-Shental, Michal Kovo","doi":"10.1007/s00404-024-07910-7","DOIUrl":"10.1007/s00404-024-07910-7","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the association between lateral placentation and adverse perinatal outcomes, including rates of small for gestational age (SGA) neonates, hypertensive (HTN) disorders, and preterm delivery, as well as postpartum hemorrhage and retained placenta.</p><p><strong>Methods: </strong>This retrospective cohort study included all women with singleton pregnancies who underwent a trial of labor after reaching 24 weeks of gestation, at a single tertiary medical center, over a period of 6 years. The study group included women with lateral placentation. Controls were women with anterior, posterior, or fundal placentation. Power analysis indicated that 882 women in each group would be sufficient to detect an increased rate of the primary outcomes: preterm delivery, hypertensive disorders or SGA in the lateral placenta group. Secondary outcomes were Apgar score, cord pH and retained placenta.</p><p><strong>Results: </strong>Overall, 1,817 (7.6%) women had lateral placenta and 21,991 (92.4%) anterior, posterior, or fundal placentation. No significant differences were observed between groups in the rates of hypertensive disorders, SGA or preterm birth. Lateral placentation was associated with a longer third stage of labor (11.1 ± 8.6 min vs. 10.4 ± 7.2 min, p = 0.001) and higher rate of retained placenta (5.7% vs. 4.2%, p = 0.002). Multivariate regression found that lateral placentation was independently associated with longer third stage of labor.</p><p><strong>Conclusion: </strong>Lateral placentation was not associated with increased rates of hypertensive disorders, preterm birth or SGA infants. It was linked to a longer third stage of labor but without a significant impact on maternal or perinatal complications.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":"93-98"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12176964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of microplastics on female reproductive health: insights from animal and human experimental studies: a systematic review.","authors":"Özen Inam","doi":"10.1007/s00404-024-07929-w","DOIUrl":"10.1007/s00404-024-07929-w","url":null,"abstract":"<p><strong>Objective: </strong>This systematic review aims to evaluate the impact of microplastics on female reproductive health by analyzing experimental studies.</p><p><strong>Method: </strong>A comprehensive search was conducted in PubMed, Web of Science, and Scopus databases to identify experimental studies published between 2021 and 2023. Studies investigating the effects of microplastics on reproductive organs, hormone levels, fertility rates, and offspring development in female subjects were included. The quality of the studies was assessed using the Cochrane risk of bias tool.</p><p><strong>Results: </strong>A total of 15 studies met the inclusion criteria. The results indicate that exposure to microplastics significantly affects ovarian function, decreases fertility rates, and disrupts hormone levels in female subjects. Several studies also reported negative effects on embryo development and offsprings health. The quality of the studies varied, with some showing a high risk of bias.</p><p><strong>Conclusion: </strong>The evidence from experimental studies suggests that microplastics have a detrimental effect on female reproductive health. However, the variation in study quality highlights the need for more rigorous research to confirm these results and better understand the underlying mechanisms.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":"77-92"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12176963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142999170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Twin delivery: does induction of labor make a difference?","authors":"L Rüegg, L Vonzun, J Wawrla-Zepf, F Krähenmann, N Ochsenbein-Kölble","doi":"10.1007/s00404-025-07939-2","DOIUrl":"10.1007/s00404-025-07939-2","url":null,"abstract":"<p><strong>Purpose: </strong>Induction of labor as well as delivery in twin pregnancies bears specific risks. The goal of this study was to analyze the delivery mode in twin pregnancies and influence of induction on the cesarean delivery (CD) rate and perinatal outcome and to identify risk factors for CD and an intertwin interval ≥ 15 min.</p><p><strong>Methods: </strong>This single-center retrospective cohort study analyzed the outcome of 267 twin pregnancies. Inclusion criteria for vaginal delivery in twins are gestational age (GA) > 34 weeks, leading twin in cephalic presentation, estimated weight difference ≤ 500 g and no previous uterine surgery. Women were divided into three groups: 1 = vaginal delivery, 2 = CD for both twins, 3 = emergency CD for second twin. Outcomes were mode of delivery, and influence of induction on the CD rate.</p><p><strong>Results: </strong>We had 156 women (58%) in group 1, 97 (36%) in 2 and 14 (5%) in 3. Induction of labor was performed in 147 cases and led to a higher CD rate (23% vs. 47%, p < 0.001). Induction of labor and nulliparity were associated with a higher risk for CD for both twins. Risk factors for an intertwin interval of ≥ 15 min were maternal age and weight of the second twin. An intertwin interval of ≥ 15 min was associated with a lower umbilical artery pH in the second twin.</p><p><strong>Conclusion: </strong>The rate of CD doubled if induction of labor was necessary. These results emphasize on careful patient counseling that includes information about the risks of deliveries in twin pregnancies.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":"99-106"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12176924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143622974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolution of lymphovascular space invasion in early-stage endometrial carcinoma: stratification, quantification, and clinical implications: a systematic review.","authors":"Hai-Yan Sun, Xu Wang, Li-Xian Wang, Qiu-Man Wang, Shan Kang","doi":"10.1007/s00404-025-07997-6","DOIUrl":"10.1007/s00404-025-07997-6","url":null,"abstract":"<p><strong>Purpose: </strong>Endometrial carcinoma (EC) represents the most prevalent malignancy of the female genital tract in the United States, with lymphovascular space invasion (LVSI) recognized as a critical prognostic factor that significantly influences disease outcomes. This review aims to elucidate the evolving understanding of LVSI in early-stage EC, highlighting its implications for stratification, quantification, and clinical management.</p><p><strong>Methods: </strong>A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Comprehensive searches of the PubMed, Web of Science, and Embase/MEDLINE databases were performed for studies published from January 1, 1985, to November 16, 2024. Peer-reviewed articles that reported multivariable hazard ratios (HR) for LVSI in endometrial cancer were included, while meta-analyses, reviews, and case reports were excluded from analysis.</p><p><strong>Results: </strong>A total of 6 studies involving 2,345 patients were included. The majority of the population was characterized by endometrioid histotype (85.7%) and classified as FIGO stage I (75.1%). LVSI was documented in 21.5% of cases, with 62.4% of patients receiving adjuvant treatment. The literature on LVSI was categorized into three thematic areas: stratification classifications, quantitative assessments, and guideline development, illustrating the progression from binary systems to more nuanced tiered classifications that enhance prognostic accuracy.</p><p><strong>Conclusion: </strong>Foundational studies established LVSI as a significant risk factor in endometrial cancer, while subsequent research has refined its classification and quantification. However, inconsistencies in LVSI thresholds among current clinical guidelines pose challenges for standardization in practice. Addressing these discrepancies through future research, including multicenter studies and the integration of emerging technologies, is crucial for improving risk stratification and clinical management of endometrial carcinoma.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":"17-23"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12176908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inherited thrombophilias and stillbirth: a systematic review and meta- analysis.","authors":"Michail Delis, Elpida Emmanouilidou-Fotoulaki, Christos Chatzakis, Theodoros Theodoridis, Alexandros Sotiriadis","doi":"10.1007/s00404-025-07989-6","DOIUrl":"10.1007/s00404-025-07989-6","url":null,"abstract":"<p><strong>Purpose: </strong>The association between inherited thrombophilias and stillbirth has been long investigated but the estimated risk remains unknown. The aim of our study is to summarize available data on the effect of Factor V Leiden, Prothrombin G20210A and MTHFR mutation, Protein S, Protein C and Anithrombin deficiency on the prevalence of stillbirth.</p><p><strong>Methods: </strong>We conducted a systematic review and meta- analysis of all relevant available PubMed, Embase and Cochrane studies until February 2024. A sensitivity analysis of only prospective and retrospective studies was performed.</p><p><strong>Results: </strong>Based on 31 included studies, Factor V Leiden and Prothrombin G202110A mutations, significantly rise the prevalence of stillbirth with a pooled OR 2.35 (95% CI 1.74-3.17) and 2.62 (95% CI 1.79-3.84), respectively. This positive correlation did not change in the sensitivity analysis. Positive correlation was also found between Antithrombin deficiency and stillbirth with a pooled OR 3.97 (95% CI 1.50-10.48). No statistically significant relationship was found between stillbirth and MTHFR mutation or Protein C and Protein S deficiency according to the random effects model.</p><p><strong>Conclusion: </strong>Our findings suggest that in the presence of certain inherited thrombophilias, the occurrence of intrauterine fetal death is significantly more prevalent.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":"37-50"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12177024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Davydov-Moore vaginoplasty in Mayer-Rokitansky-Küster-Hauser syndrome: sexual and surgical outcomes.","authors":"Magdalena Piróg, Magdalena Bednarczyk, Katarzyna Barabasz, Olga Kacalska-Janssen, Robert Jach","doi":"10.1007/s00404-024-07830-6","DOIUrl":"10.1007/s00404-024-07830-6","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to compare surgical and sexual outcomes after Davidov-Moore vaginoplasty in women with Mayer-Rokitansky-Küster-Hauser syndrome (MRKH).</p><p><strong>Methods: </strong>In the case-series study, we described seven women, at a median age of 22.6 ± and BMI 22.8 ± 2.3 kg/m². We measured peri- and postsurgical parameters, including surgery-related neovaginal length and sexual initiation time. Sexual outcomes were measured using the Female Sexual Function Index (FSFI) before and 6 months after vaginoplasty.</p><p><strong>Results: </strong>All surgical procedures were performed successfully, with one minor perioperative bleeding. The mean time of vaginoplasty was 82.1 min and the mean duration of hospitalization was six days. After a 6-month follow-up, vaginal length was 8.1-times longer than before surgery (10 vs. 81 mm). The time from the surgery to the initiation of vaginal intercourse was between 17 to 22 weeks. The mean FSFI score indicated good results, with no women below 23 score, and was 4.3- times higher when compared with the pre-surgical one (6.7 vs 29.1). Contrary to the FSFI score before surgery, the post-surgical FSFI revealed higher scores in all six different domains: desire (2.5-times), arousal (4.1-times), lubrication (3.8-times), orgasm (3.4-times), satisfaction (3.3-times) and comfort (11-times).</p><p><strong>Conclusion: </strong>Laparoscopic Davydov-Moore vaginoplasty might be considered as a safe procedure with satisfactory anatomic and sexual outcomes. It should be considered as a treatment option for the creation of neovagina in women with MRKH.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":"119-124"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12176954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of updated imaging software on the performance of machine learning models for breast cancer diagnosis: a multi-center, retrospective study.","authors":"Lie Cai, Michael Golatta, Chris Sidey-Gibbons, Richard G Barr, André Pfob","doi":"10.1007/s00404-024-07901-8","DOIUrl":"10.1007/s00404-024-07901-8","url":null,"abstract":"<p><strong>Purpose: </strong>Artificial Intelligence models based on medical (imaging) data are increasingly developed. However, the imaging software on which the original data is generated is frequently updated. The impact of updated imaging software on the performance of AI models is unclear. We aimed to develop machine learning models using shear wave elastography (SWE) data to identify malignant breast lesions and to test the models' generalizability by validating them on external data generated by both the original updated software versions.</p><p><strong>Methods: </strong>We developed and validated different machine learning models (GLM, MARS, XGBoost, SVM) using multicenter, international SWE data (NCT02638935) using tenfold cross-validation. Findings were compared to the histopathologic evaluation of the biopsy specimen or 2-year follow-up. The outcome measure was the area under the curve (AUROC).</p><p><strong>Results: </strong>We included 1288 cases in the development set using the original imaging software and 385 cases in the validation set using both, original and updated software. In the external validation set, the GLM and XGBoost models showed better performance with the updated software data compared to the original software data (AUROC 0.941 vs. 0.902, p < 0.001 and 0.934 vs. 0.872, p < 0.001). The MARS model showed worse performance with the updated software data (0.847 vs. 0.894, p = 0.045). SVM was not calibrated.</p><p><strong>Conclusion: </strong>In this multicenter study using SWE data, some machine learning models demonstrated great potential to bridge the gap between original software and updated software, whereas others exhibited weak generalizability.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":"139-147"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12176987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143062872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of sperm DNA fragmentation on embryo morphokinetic parameters and laboratory outcomes in women of different ages during intracytoplasmic sperm treatment cycles.","authors":"Danna Ye, Zhujun Ye, Huan Zhang","doi":"10.1007/s00404-025-07949-0","DOIUrl":"10.1007/s00404-025-07949-0","url":null,"abstract":"<p><strong>Background: </strong>Whether SDF (sperm DNA fragmentation) influences embryo development and the clinical outcomes of assisted reproductive technology (ART) cycles remains controversial. Oocytes derived from women of different ages have varying abilities to repair SDF.</p><p><strong>Objective: </strong>This study aimed to explore the correlation between SDF and the morphokinetic parameters of embryos during intracytoplasmic sperm injection (ICSI) treatment cycles with consideration of the different ages of female patients.</p><p><strong>Materials and methods: </strong>A total of 301 ICSI cycles between April 2022 and December 2023 were analyzed in this retrospective study. Cycles were categorized into two groups according to female age: the older group (females aged ≥ 35 years) and the younger group (females aged < 35 years). Moreover, each age group was further divided into low- and high- sperm DNA fragmentation index (DFI) subgroups. The morphokinetic parameters of embryo development and the laboratory outcomes were compared between the two DFI subgroups within each age category.</p><p><strong>Results: </strong>In the younger group, there were no differences between the two DFI groups in terms of the rate of usable blastocyst formation on Day 5; time to 2, 3, 4, 5, 6, 7, and 8 cells; or timing of blastulation. However, in the older group, the rate of usable blastocyst formation on Day 5 was significantly greater in the low DFI group than in the high DFI group (35.6% vs. 23.4%, p = 0.030). Although the times to reach 2, 3, 4, 5, 6, 7, and 8 cells were similar across the two DFI groups, the time to blastulation (tB) was significantly shorter in the low DFI group than in the high DFI group (106.5 ± 9.0 h vs. 111.1 ± 10.3 h, p = 0.013).</p><p><strong>Conclusion: </strong>SDF could adversely affect the rate of usable blastocyst formation on Day 5 and delay the formation of usable blastocysts only when oocytes were derived from women of advanced maternal age. These results may indicate that oocytes derived from younger females have a greater capacity to repair SDF than those from women of advanced maternal age.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":"191-196"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12177009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body image and mental health in women with polycystic ovary syndrome-a cross-sectional study.","authors":"Konstantin Hofmann, Claire Decrinis, Norman Bitterlich, Katharina Tropschuh, Petra Stute, Annette Bachmann","doi":"10.1007/s00404-024-07913-4","DOIUrl":"10.1007/s00404-024-07913-4","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Purpose: &lt;/strong&gt;Polycystic Ovary Syndrome (PCOS) is a multifaceted endocrine-metabolic condition affecting around 5-15% of women globally. Despite its prevalence and diverse impact, the psychological aspect of PCOS is often underestimated in clinical settings, leading to significant distress among affected individuals. This study aimed to explore the extent of body image perception disorders, psychological comorbidities, and their influence on the health-related quality of life (HRQOL) in women with PCOS. Additionally, we focused on measuring the impact of factors associated with PCOS, particularly obesity, to gain a more comprehensive understanding of their effects.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;An online survey was distributed anonymously to gynecologists, hospitals, and women's clinics across Austria, Germany, and Switzerland, as well as through social media platforms to connect with women with PCOS. The survey was conducted from November 14, 2023, to February 05, 2024. HRQOL, anxiety/depression levels, body image and self-esteem were assessed employing the Modified-PCOS-Questionnaire (MPCOSQ), Hospital Anxiety and Depression Scale (HADS), Multidimensional Body-Self Relations Questionnaire Appearance Scales (MBSRQ-AS) and Rosenberg Self-Esteem Scale (RSE) respectively. Identification of potential confounding variables relied on their plausibility and association with the estimate. Adjusted odds ratios and their respective 95% confidence intervals were computed through regression analysis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;587 participants fully completed the questionnaire. The study participants were on average 32.5 ± 5.9 years old and had a BMI of 31.3 ± 7.8 kg/m&lt;sup&gt;2&lt;/sup&gt;. In this study, 84.5% of all PCOS patients exhibited pathological scores in the MBSRQ-AS Appearance Evaluation, 83.8% in Body Areas Satisfaction, and 67.5% in Overweight Preoccupation. Half of the participants (46.7%) showed significantly poor results in the RSE, indicating low self-esteem. A notable portion of the study participants displayed elevated HADS scores, which supports a higher rate of distress in PCOS patients. (HADS-Anxiety &gt; 8: 75.0% (440); HADS-Depression &gt; 8: 57.6% (338). Examining the HRQOL of PCOS patients revealed that all average scores of the subscales, except for the Acne subscale and MPCOSQ-Total (3.6 ± 1:0), were situated in the lower half, indicating diminished HRQOL. The linear regression revealed that pathological values in the MBSRQ-AS, indicating impaired body image, were associated with low scores in the MPCOSQ subscales and HADS scales, suggesting impaired HRQOL and a higher rate of distress in PCOS patients. Furthermore, the multivariate analysis showed a statistically significant link between adverse body perception and HRQOL, as well as distress among PCOS patients in this study group. [multivariate HADS-Anxiety: MBSRQ-AS Body Areas Satisfaction (B: - 2.10; CI: - 3.88; - 0.33; p = 0.02) HADS-Depression MBSRQ-AS Body Areas Sat","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":"177-190"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12176914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}