Inherited thrombophilias and stillbirth: a systematic review and meta- analysis.

IF 2.1 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Archives of Gynecology and Obstetrics Pub Date : 2025-03-14 DOI:10.1007/s00404-025-07989-6

Michail Delis, Elpida Emmanouilidou-Fotoulaki, Christos Chatzakis, Theodoros Theodoridis, Alexandros Sotiriadis

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引用次数: 0

Abstract

Purpose: The association between inherited thrombophilias and stillbirth has been long investigated but the estimated risk remains unknown. The aim of our study is to summarize available data on the effect of Factor V Leiden, Prothrombin G20210A and MTHFR mutation, Protein S, Protein C and Anithrombin deficiency on the prevalence of stillbirth.

Methods: We conducted a systematic review and meta- analysis of all relevant available PubMed, Embase and Cochrane studies until February 2024. A sensitivity analysis of only prospective and retrospective studies was performed.

Results: Based on 31 included studies, Factor V Leiden and Prothrombin G202110A mutations, significantly rise the prevalence of stillbirth with a pooled OR 2.35 (95% CI 1.74-3.17) and 2.62 (95% CI 1.79-3.84), respectively. This positive correlation did not change in the sensitivity analysis. Positive correlation was also found between Antithrombin deficiency and stillbirth with a pooled OR 3.97 (95% CI 1.50-10.48). No statistically significant relationship was found between stillbirth and MTHFR mutation or Protein C and Protein S deficiency according to the random effects model.

Conclusion: Our findings suggest that in the presence of certain inherited thrombophilias, the occurrence of intrauterine fetal death is significantly more prevalent.

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遗传性血栓和死产：系统回顾和荟萃分析。

目的：遗传性血栓和死产之间的关系已经研究了很长时间，但估计的风险仍然未知。本研究的目的是总结现有的关于Leiden因子V、凝血酶原G20210A和MTHFR突变、蛋白S、蛋白C和抗凝血酶缺乏对死产发生率的影响的数据。方法：我们对截至2024年2月的所有相关PubMed、Embase和Cochrane研究进行了系统回顾和荟萃分析。仅对前瞻性和回顾性研究进行敏感性分析。结果：基于31项纳入的研究，Leiden因子V和凝血酶原G202110A突变显著增加死产的患病率，合并OR分别为2.35 （95% CI 1.74-3.17）和2.62 （95% CI 1.79-3.84）。这种正相关性在敏感性分析中没有改变。抗凝血酶缺乏与死产也呈正相关，合并OR为3.97 （95% CI 1.50-10.48）。根据随机效应模型，死产与MTHFR突变或Protein C和Protein S缺乏之间无统计学意义的关系。结论：我们的研究结果表明，在存在某些遗传性血栓的情况下，宫内胎儿死亡的发生率明显更普遍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Gynecology and Obstetrics 医学-妇产科学

CiteScore

4.70

自引率

15.40%

发文量

493

审稿时长

1 months

期刊介绍： Founded in 1870 as "Archiv für Gynaekologie", Archives of Gynecology and Obstetrics has a long and outstanding tradition. Since 1922 the journal has been the Organ of the Deutsche Gesellschaft für Gynäkologie und Geburtshilfe. "The Archives of Gynecology and Obstetrics" is circulated in over 40 countries world wide and is indexed in "PubMed/Medline" and "Science Citation Index Expanded/Journal Citation Report". The journal publishes invited and submitted reviews; peer-reviewed original articles about clinical topics and basic research as well as news and views and guidelines and position statements from all sub-specialties in gynecology and obstetrics.