Archives of Gynecology and Obstetrics最新文献

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Limitations and perspectives of the novel salivary test for endometriosis: an open web-based survey study of German gynecologic healthcare providers. 新型子宫内膜异位症唾液检验的局限性和前景:一项针对德国妇科医疗服务提供者的开放式网络调查研究。
IF 2.1 3区 医学
Archives of Gynecology and Obstetrics Pub Date : 2024-09-26 DOI: 10.1007/s00404-024-07601-3
Meletios P Nigdelis, Merle Doerk, Stefanie Burghaus, Martin Sillem, Bashar Haj Hamoud, Erich-Franz Solomayer, Gregor Leonhard Olmes
{"title":"Limitations and perspectives of the novel salivary test for endometriosis: an open web-based survey study of German gynecologic healthcare providers.","authors":"Meletios P Nigdelis, Merle Doerk, Stefanie Burghaus, Martin Sillem, Bashar Haj Hamoud, Erich-Franz Solomayer, Gregor Leonhard Olmes","doi":"10.1007/s00404-024-07601-3","DOIUrl":"https://doi.org/10.1007/s00404-024-07601-3","url":null,"abstract":"<p><strong>Introduction: </strong>The description of a salivary miRNA signature for endometriosis has led to the development of a non-invasive diagnostic test. Current healthcare provider practices regarding the test remain uncaptured. The application of this test in practice was examined in a web-based survey, with the aim to provide their opinions on it.</p><p><strong>Methods: </strong>We conducted an open web-based survey study between November 2023 and January 2024. Members of the German society of gynecologic endoscopy (Arbeitsgemeinschaft gynäkologische Endoskopie, AGE), society of endometriosis (Arbeitsgemeinschaft Endometriose, AGEM), and the endometriosis research foundation (Stiftung Endometriose Forschung, SEF) were contacted per e-mail twice. Participants' data were anonymized. Differences in responses based on self-reported expertise in the field (basic knowledge, specialized knowledge, expert) were assessed using the χ<sup>2</sup>-test or Fisher's exact test. Statistical significance was set as p < 0.05.</p><p><strong>Results: </strong>In total 141 of 190 respondents completely responded to the survey (> 75% of the questions of the survey). Twenty-one physicians reported having experience with the test, while most participants had at least specialized knowledge on the field (112/141). In terms of specific questions, more than 90% found the costs high; almost 85% did not believe that the test replaces standard diagnostic tools (histology, clinical examination, and sonography). Eighty-six providers supported the use of the test in adolescents. Gynecologists with basic knowledge had a more positive attitude compared with more experienced ones in terms of usefulness (Fisher's exact test, p < 0.001). Significant differences were demonstrated between expertise groups regarding (not only) applicability in adolescents (Fisher's exact test, p = 0.004), and using the test for screening purposes (χ<sup>2</sup>-test, p = 0.002).</p><p><strong>Discussion: </strong>Despite the promising benefits of a salivary test for endometriosis, German healthcare providers would not change current practices. Nevertheless, less experienced colleagues were more positive towards the test.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142340121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between pelvic inflammatory disease and risk of ovarian, uterine, cervical, and vaginal cancers—a meta-analysis 盆腔炎与卵巢癌、子宫癌、宫颈癌和阴道癌风险之间的关系--荟萃分析。
IF 2.1 3区 医学
Archives of Gynecology and Obstetrics Pub Date : 2024-09-26 DOI: 10.1007/s00404-024-07748-z
Azharuddin Sajid Syed Khaja, Mohd Saleem, Mubashir Zafar, Soha Moursi, Ghorashy Eltayeb Yousif Mohammed, Syed Monowar Alam Shahid, Sahar Hammam, Safia Moussa, Mohammed Salem Alharbi, Ahmed Nawi Alshammari
{"title":"Association between pelvic inflammatory disease and risk of ovarian, uterine, cervical, and vaginal cancers—a meta-analysis","authors":"Azharuddin Sajid Syed Khaja,&nbsp;Mohd Saleem,&nbsp;Mubashir Zafar,&nbsp;Soha Moursi,&nbsp;Ghorashy Eltayeb Yousif Mohammed,&nbsp;Syed Monowar Alam Shahid,&nbsp;Sahar Hammam,&nbsp;Safia Moussa,&nbsp;Mohammed Salem Alharbi,&nbsp;Ahmed Nawi Alshammari","doi":"10.1007/s00404-024-07748-z","DOIUrl":"10.1007/s00404-024-07748-z","url":null,"abstract":"<div><h3>Background and aim</h3><p>The present meta-analysis aims to investigate a potential link between pelvic inflammatory disease (PID) and an increased risk of genitourinary cancers (ovarian, cervical, uterus, and vagina cancers). While previous research has hinted at a possible link, this meta-analysis seeks to delve deeper into the available evidence. Understanding this association is crucial for preventive strategies and improving clinical management practices.</p><h3>Methodology</h3><p>A comprehensive literature search was conducted across various databases, covering studies published between 2016 and 2024. We included 13 observational studies meeting stringent criteria, followed by meticulous data extraction and quality assessment. Meta-analytical techniques were then employed to calculate pooled odds ratios (ORs), adjusted hazard ratios (HRs), and 95% confidence intervals (CIs), with heterogeneity assessed using the I<sup>2</sup> statistic.</p><h3>Results</h3><p>Our analysis revealed significant findings, underscoring the association between PID and increased risks of genitourinary cancers. Specifically, individuals with a history of PID demonstrated notably higher odds of developing ovarian cancer (OR = 1.477, 95% CI 1.033–2.207), uterine cancer (OR = 1.263, 95% CI 0.827–2.143), cervical cancer (OR = 1.000, 95% CI 0.900–1.100), and vaginal cancer (OR = 2.500, 95% CI 1.400–4.000) compared to those without such a history. The overall heterogeneity across studies was high (<i>I</i><sup>2</sup> = 82.92%), suggesting varying trends across different populations and study designs.</p><h3>Conclusion</h3><p>This meta-analysis provides updated evidence supporting a significant association between PID and an increased risk of cervical, ovarian, and uterine cancers. Early detection and management of PID are crucial in potentially mitigating the risk of these cancers.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"310 5","pages":"2577 - 2585"},"PeriodicalIF":2.1,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142340116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
First-degree family history of cancers in patients with stage I endometrial carcinoma. Prevalence and prognostic impact I 期子宫内膜癌患者的一级癌症家族史。发病率和对预后的影响。
IF 2.1 3区 医学
Archives of Gynecology and Obstetrics Pub Date : 2024-09-26 DOI: 10.1007/s00404-024-07728-3
Abdelrahman Yousif, Zuber D. Mulla, Julia Pudar, Muneer Elshaikh, Remonda Khalil-Moawad, Mohamed A. Elshaikh
{"title":"First-degree family history of cancers in patients with stage I endometrial carcinoma. Prevalence and prognostic impact","authors":"Abdelrahman Yousif,&nbsp;Zuber D. Mulla,&nbsp;Julia Pudar,&nbsp;Muneer Elshaikh,&nbsp;Remonda Khalil-Moawad,&nbsp;Mohamed A. Elshaikh","doi":"10.1007/s00404-024-07728-3","DOIUrl":"10.1007/s00404-024-07728-3","url":null,"abstract":"<div><h3>Background</h3><p>We aimed to study the impact of first-degree family history on patients with endometrial cancer.</p><h3>Methods</h3><p>We conducted a retrospective chart review from January 1990 to June 2016, comparing stage I endometrial cancer patients with and without a sporadic family history of cancers. We collected the patients’ demographic information, tumor characteristics, and treatment plans. During the follow-up period, patient information on tumor recurrence and survival was collected. The chi-square test was used to assess the associations between categorical variables. The Cox proportional hazards regression model was used to estimate multivariate-adjusted hazard ratios (95% confidence interval (CI)).</p><h3>Results</h3><p>Among the 1737 patients with stage I endometrial cancer, 709 had a positive first-degree family history of cancers and 1028 had negative family history (FH) of cancers. Patients with positive FH were more likely to be older, have stage IB disease, and receive adjuvant radiotherapy; however, the difference was not statistically significant. At 5 years follow up, patients with a positive family history had longer time to recurrence (TTR) than their negative FH counterparts. Maternal family history of cancer was the most common, followed by a sister’s history of cancer, paternal history, brother’s history, and offspring history of cancer. Breast, endometrial, and colon cancers are the most common cancers among first-degree relatives.</p><h3>Conclusion</h3><p>Endometrial cancer patients with sporadic first-degree FH of cancers share similar demographics and tumor characteristics compared to their counterpart with slightly increased likelihood to be older, with stage IB disease and have a longer TTR compared to their negative counterpart.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"310 5","pages":"2595 - 2602"},"PeriodicalIF":2.1,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142340120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Utility of routine mid-trimester fetal ultrasound scan in detecting filar cysts and follow-up outcomes 常规中期胎儿超声扫描在检测丝状囊肿中的作用及随访结果。
IF 2.1 3区 医学
Archives of Gynecology and Obstetrics Pub Date : 2024-09-26 DOI: 10.1007/s00404-024-07750-5
Jingping Wu
{"title":"Utility of routine mid-trimester fetal ultrasound scan in detecting filar cysts and follow-up outcomes","authors":"Jingping Wu","doi":"10.1007/s00404-024-07750-5","DOIUrl":"10.1007/s00404-024-07750-5","url":null,"abstract":"<div><h3>Purpose</h3><p>To assess the value of routine mid-trimester fetal ultrasound scans in detecting FCs, as well as the related ultrasound and clinical follow-up outcomes.</p><h3>Methods</h3><p>A retrospective analysis was conducted on 1064 fetuses who underwent standardized ultrasound screening during the mid-trimester. During the examination, high-frequency ultrasound was used to examine the fetal spine. Different frequency ultrasound probes were used to compare and analyze the detection rates of FCs. We conducted follow-up ultrasound observations on all FCs and conducted long-term follow-up observations in terms of the motor function of the children after birth.</p><h3>Results</h3><p>Among 1064 fetuses detected by ultrasound, a total of 910 fetuses were completely evaluated using high-frequency and low-frequency ultrasound, and 24 FCs were found. In all 24 cases of FCs, 7 cases were detected using low-frequency ultrasound, while high-frequency ultrasound detected all cases. There was a significant difference in the detection rates between the two groups (χ<sup>2</sup> = 26.323, <i>P</i> = 0.000). Of all the 24 FCs, 21 cysts disappeared spontaneously (87.5%); one fetus was induced for abortion due to a concurrent cleft lip; after multiple ultrasound examinations, it was found that the cyst persisted in one fetus; one case was not followed up by ultrasound. There was no statistically significant difference in the start of sitting and crawling time between the control group and the FCs group.</p><h3>Conclusion</h3><p>Routine mid-trimester fetal ultrasound scan detect FCs, particularly when high-frequency ultrasound probes were routinely applied. Most FCs detected by prenatal ultrasound spontaneously disappear and have no impact on the motor function of the fetus after birth (with the conus medullaris located at or above the L3 level). The shortest time interval from the detection to the disappearance of the cyst was 11 days.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"310 5","pages":"2553 - 2559"},"PeriodicalIF":2.1,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142340137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Post-operative outcomes associated with anterior mesh location after laparoscopic sacrocolpopexy 腹腔镜骶尾部结肠切除术后与网片前部位置相关的术后效果。
IF 2.1 3区 医学
Archives of Gynecology and Obstetrics Pub Date : 2024-09-25 DOI: 10.1007/s00404-024-07719-4
Nassir Habib, Matteo Giorgi, Tania Tahtouh, Amel Hamdi, Gabriele Centini, Alberto Cannoni, Georges Bader
{"title":"Post-operative outcomes associated with anterior mesh location after laparoscopic sacrocolpopexy","authors":"Nassir Habib,&nbsp;Matteo Giorgi,&nbsp;Tania Tahtouh,&nbsp;Amel Hamdi,&nbsp;Gabriele Centini,&nbsp;Alberto Cannoni,&nbsp;Georges Bader","doi":"10.1007/s00404-024-07719-4","DOIUrl":"10.1007/s00404-024-07719-4","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the relationship between the anatomical position of the anterior arm of the mesh, measured by ultrasound through the bladder neck–mesh distance technique and the surgical outcomes after laparoscopic sacrocolpopexy (SCP) for apical prolapse.</p><h3>Study design</h3><p>It was a retrospective analysis of prospectively collected data in a tertiary care hospital. Between January 2019 and September 2019, 63 women who underwent laparoscopic SCP due to apical prolapse were included. Bladder neck–mesh distance was measured immediately after surgery. The pelvic floor was evaluated using the Pelvic Organ Prolapse Quantification (POP-Q) System before, 1 month, and 2.7 years (mid-term) after the surgery. Post-operative stress urinary incontinence (SUI) and Patient Global Impression of Improvement (PGI-I) scores were also assessed. The correlation between bladder neck–mesh distance and the post-operative outcomes was investigated using the Spearman rank correlation coefficient.</p><h3>Results</h3><p>At mid-term follow-up visit, bladder neck–mesh distance was inversely correlated with the correction of apical prolapse and post-operative SUI. No correlation was detected with the anterior compartment prolapse correction. PGI-I scores were high in all patients at mid-term follow-up, irrespective of bladder neck–mesh distance values.</p><h3>Conclusion</h3><p>The shorter the bladder neck–mesh distance, the better the outcome for apical compartment repair. Bladder neck–mesh distance had no correlation with the anterior anatomical correction. Shorter bladder neck–mesh distance values were positively correlated to better PGI-I scores and a higher risk of SUI.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"310 5","pages":"2717 - 2724"},"PeriodicalIF":2.1,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142340135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cervical length evolution in pregnancy and prediction of preterm delivery 孕期宫颈长度变化与早产预测
IF 2.1 3区 医学
Archives of Gynecology and Obstetrics Pub Date : 2024-09-23 DOI: 10.1007/s00404-024-07745-2
A. P. Souka, V. Maritsa, P. Antsaklis, A. Pilalis, G. Daskalakis
{"title":"Cervical length evolution in pregnancy and prediction of preterm delivery","authors":"A. P. Souka,&nbsp;V. Maritsa,&nbsp;P. Antsaklis,&nbsp;A. Pilalis,&nbsp;G. Daskalakis","doi":"10.1007/s00404-024-07745-2","DOIUrl":"10.1007/s00404-024-07745-2","url":null,"abstract":"<div><h3>Purpose</h3><p>To construct reference charts for cervical length (CL) in pregnancy based on longitudinal measurements and to assess the value of measuring cervical length after 24 weeks of gestation.</p><h3>Methods</h3><p>CL was measured transvaginally in singleton pregnancies at 5 to 41 weeks. Pregnancies with more than one measurement were used for creating the CL chart, whereas any measurement after 24 weeks was considered for assessing the correlation of CL with preterm delivery.</p><h3>Results</h3><p>The dataset consisted of 12,601 pregnancies and 33,899 observations. Gestational age was the main predictor of CL (R<sup>2</sup> = 67.3%). Further adjustments in the fixed effects part for maternal characteristics (age, BMI, smoking status, parity, history of miscarriage, and cervical surgery) improved the prediction ability (R<sup>2</sup> = 78.4%). CL was predictive of spontaneous preterm delivery before 37 weeks when measured at any gestation between 24 and 35 weeks and it was predictive of spontaneous preterm delivery before 32 weeks when measured between 28 and 31 weeks (AUC = 0.68).</p><h3>Conclusion</h3><p>Gestational age is the main predictor of CL followed by maternal characteristics and history. CL assessment between 24 and 35 + 6 weeks can enhance our ability to predict spontaneous preterm delivery.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"310 5","pages":"2477 - 2485"},"PeriodicalIF":2.1,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trial of labor following cesarean among patients with polyhydramnios: a multicenter retrospective study 多胎妊娠患者剖宫产后试产:一项多中心回顾性研究。
IF 2.1 3区 医学
Archives of Gynecology and Obstetrics Pub Date : 2024-09-21 DOI: 10.1007/s00404-024-07742-5
Ari Weiss, Tzuria Peled, Reut Rotem, Hen Y. Sela, Sorina Grisaru-Granovsky, Misgav Rottenstreich
{"title":"Trial of labor following cesarean among patients with polyhydramnios: a multicenter retrospective study","authors":"Ari Weiss,&nbsp;Tzuria Peled,&nbsp;Reut Rotem,&nbsp;Hen Y. Sela,&nbsp;Sorina Grisaru-Granovsky,&nbsp;Misgav Rottenstreich","doi":"10.1007/s00404-024-07742-5","DOIUrl":"10.1007/s00404-024-07742-5","url":null,"abstract":"<div><h3>Purpose</h3><p>This study aimed to assess maternal and neonatal outcomes in patients with polyhydramnios attempting trial of labor after cesarean (TOLAC) compared to those undergoing planned repeat cesarean delivery (PRCD).</p><h3>Methods</h3><p>A multi-center retrospective cohort study was conducted and included women with term singleton viable pregnancies following a single low-segment transverse cesarean delivery (CD) with a polyhydramnios diagnosis (maximal vertical pocket &gt; 8 cm and/or Amniotic Fluid Index &gt; 24 cm) within 14 days before birth who delivered between the years 2017 and 2021. Maternal and neonatal outcomes were compared between those attempting TOLAC and those opting for PRCD. The primary outcome was composite adverse maternal. Univariate analysis was followed by multivariate analysis to control for potential confounders.</p><h3>Results</h3><p>Out of 358 included births with a previous CD, 208 (58.1%) attempted TOLAC, while 150 had PRCD (41.9%). The successful vaginal birth after cesarean (VBAC) rate was 82.2%, and no cases of uterine rupture, hysterectomy, or maternal intensive care unit admission occurred in either group. After controlling for potential confounders, no independent association between TOLAC and composite adverse maternal (adjusted odds ratio [aOR] 0.62, 95% confidence interval [CI] 0.32–1.20, <i>p</i> = 0.16) and neonatal (aOR 0.89, 95% CI 0.51–1.53, <i>p</i> = 0.67) adverse outcomes was demonstrated.</p><h3>Conclusion</h3><p>In patients with a term diagnosed polyhydramnios, TOLAC appears to be a reasonable alternative associated with favorable outcomes. Larger prospective studies are needed to refine management strategies and enhance maternal and neonatal outcomes in this context.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"310 5","pages":"2469 - 2476"},"PeriodicalIF":2.1,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improved contingent screening strategy increased trisomy 21 detection rate in the second trimester. 改进后的应急筛查策略提高了 21 三体综合征在妊娠后三个月的检出率。
IF 2.1 3区 医学
Archives of Gynecology and Obstetrics Pub Date : 2024-09-21 DOI: 10.1007/s00404-024-07743-4
Wei Luo, Bin He, Daiwen Han, Lixing Yuan, Jun Tang, Ling Pang, Kai Zhao, Fene Zou, Ting Hu, Shanling Liu
{"title":"Improved contingent screening strategy increased trisomy 21 detection rate in the second trimester.","authors":"Wei Luo, Bin He, Daiwen Han, Lixing Yuan, Jun Tang, Ling Pang, Kai Zhao, Fene Zou, Ting Hu, Shanling Liu","doi":"10.1007/s00404-024-07743-4","DOIUrl":"https://doi.org/10.1007/s00404-024-07743-4","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to establish suitable threshold values for biochemical indicators in low-risk pregnant women who underwent second trimester screening and design strategies for consecutive prenatal testing to increase trisomy 21 detection.</p><p><strong>Methods: </strong>This study examined singleton pregnant women who underwent double, triple, or quadruple screening in the second trimester over six years. To obtain adequate detection efficiency for low-risk pregnancies, threshold values for serum biochemical indicators were established, and a cost-effectiveness assessment of the improved contingent screening strategy was conducted.</p><p><strong>Results: </strong>Participants were included in serum double- (n = 88,550), triple- (n = 29,991), and quadruple-screening (n = 15,004) groups. Threshold values were defined as having a free beta subunit of human chorionic gonadotropin (free β-hCG) multiple of the median (MoM) ≥ 2.50, alpha-fetoprotein (AFP) MoM ≤ 0.50, or unconjugated estriol (uE3) MoM ≤ 0.70 for low risk. Low-risk pregnancies, comprising 1.35% (988/73,183), 4.45% (1,171/26,286), and 11.91% (1,559/13,085) of the double-, triple-, and quadruple-screening groups, respectively, underwent further non-invasive prenatal screening. In the double-, triple-, and quadruple-screening groups, we detected 11.76% (2/17), 40.00% (2/5), and 66.67% (2/3) of trisomy 21 cases with false negative results, respectively, with the overall detection rates of 85.00% (85/100), 90.63% (29/32), and 95.24% (20/21), respectively, and decreased ratio of overall costs of 5.26%, 16.63%, and 24.36%, respectively.</p><p><strong>Conclusion: </strong>Utilizing threshold values of AFP, free β-hCG, and uE3 to trigger further non-invasive prenatal screening may increase trisomy 21 detection in pregnancies deemed low risk in the second trimester while reducing the overall costs of screening strategies.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Severe ovarian hyperstimulation syndrome following sole gonadotropin-releasing hormone (GnRH) agonist trigger: a case series and literature review 单纯促性腺激素释放激素(GnRH)激动剂触发后的严重卵巢过度刺激综合征:病例系列和文献综述。
IF 2.1 3区 医学
Archives of Gynecology and Obstetrics Pub Date : 2024-09-20 DOI: 10.1007/s00404-024-07740-7
Roza Berkovitz-Shperling, Nivin Samara, Reut Meir, Omri Dominsky, Foad Azam, Ido Feferkorn
{"title":"Severe ovarian hyperstimulation syndrome following sole gonadotropin-releasing hormone (GnRH) agonist trigger: a case series and literature review","authors":"Roza Berkovitz-Shperling,&nbsp;Nivin Samara,&nbsp;Reut Meir,&nbsp;Omri Dominsky,&nbsp;Foad Azam,&nbsp;Ido Feferkorn","doi":"10.1007/s00404-024-07740-7","DOIUrl":"10.1007/s00404-024-07740-7","url":null,"abstract":"<div><h3>Objective</h3><p>The aim of this study was to report three cases of early severe ovarian hyperstimulation syndrome (OHSS) in patients undergoing a GnRH antagonist protocol triggered with GnRH agonist (GnRH-a), leading to hospitalization and the need for peritoneal drainage. Additionally, a review of the existing literature on this topic is provided.</p><h3>Design</h3><p>This is a retrospective case series and a literature review.</p><h3>Setting</h3><p>This study was conducted at obstetrics and gynecology department of tertiary academic referral hospitals, Israel.</p><h3>Participants</h3><p>This study included three patients presented with severe OHSS symptoms, including abdominal distension, ascites, and hemoconcentration.</p><h3>Main outcome measures</h3><p>The main focus of the treatment was to address the symptoms and prevent any further complications. The outcome was the complete recovery of the patients.</p><h3>Results</h3><p>The presented cases detail instances of severe OHSS following oocyte retrieval, utilizing GnRH-a for triggering. Case 1 involved a 33-year-old patient with a history of polycystic ovary syndrome (PCOS), Case 2 featured a 22-year-old patient with familial adenomatous polyposis (FAP), and Case 3 included a 41-year-old patient with a history of depressive disorder. All patients receiving supportive care, including infusions and medications, exhibited gradual improvement during hospitalization, with complete resolution observed during the 20-day post-hospitalization check-up.</p><h3>Conclusions</h3><p>These three cases highlight the occurrence of severe early OHSS following a GnRH antagonist protocol triggered with GnRH-a in the absence of human chorionic gonadotropin (hCG) administration for trigger or luteal-phase support. Clinicians must be aware that a GnRH-a trigger followed by a freeze-all approach does not guarantee the complete elimination of OHSS in all patients.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"310 5","pages":"2297 - 2304"},"PeriodicalIF":2.1,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-024-07740-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sleep duration and sleep loss during pregnancy: a longitudinal FinnBrain birth cohort study 怀孕期间的睡眠时间和睡眠损失:FinnBrain 出生队列纵向研究。
IF 2.1 3区 医学
Archives of Gynecology and Obstetrics Pub Date : 2024-09-20 DOI: 10.1007/s00404-024-07727-4
Linda Aukia, E. Juulia Paavonen, Linnea Karlsson, Juho Pelto, Laura Perasto, Hasse Karlsson, Päivi Polo-Kantola
{"title":"Sleep duration and sleep loss during pregnancy: a longitudinal FinnBrain birth cohort study","authors":"Linda Aukia,&nbsp;E. Juulia Paavonen,&nbsp;Linnea Karlsson,&nbsp;Juho Pelto,&nbsp;Laura Perasto,&nbsp;Hasse Karlsson,&nbsp;Päivi Polo-Kantola","doi":"10.1007/s00404-024-07727-4","DOIUrl":"10.1007/s00404-024-07727-4","url":null,"abstract":"<div><h3>Purpose</h3><p>To investigate sleep duration and sleep loss during antenatal period and assess associative factors, including maternal characteristic and mood symptoms.</p><h3>Methods</h3><p>A cohort of 3038 women was enrolled. Self-reported sleep duration and sleep loss, the latter being calculated from preferred sleep need and actual sleep duration, were measured in early, mid- and late pregnancy, and at delivery. The associations with age, BMI, parity, education, smoking, napping, and depressive and anxiety symptoms were evaluated.</p><h3>Results</h3><p>Sleep duration was longest in early pregnancy and shortest at delivery (7.93 h–7.76 h, <i>p</i> &lt; 0.001). The proportion of short sleepers (&lt; 6 h) increased from 1.4% to 5.9% throughout the studied period (<i>p</i> &lt; 0.001). Mean sleep loss remained stable in early- and mid-pregnancy, lowering in late pregnancy (<i>p</i> &lt; 0.001) and increasing again until delivery (<i>p</i> = 0.003). The number of women with notable sleep loss (&gt; 2 h) was similar during the first three measurement points (9.4%, 8.9% and 9.5%), but increased until delivery (14.1%, <i>p</i> &lt; 0.001). Older, multiparous, and more-depressive women slept less (<i>p</i> &lt; 0.001, <i>p</i> &lt; 0.001, <i>p</i> = 0.017). Women with higher BMI were more likely to sleep &lt; 6 h in late pregnancy (<i>p</i> = 0.012). Multiparous, more-depressive, and higher-BMI women reported more sleep loss (<i>p</i> &lt; 0.001, <i>p</i> &lt; 0.001, <i>p</i> = 0.049).</p><h3>Conclusion</h3><p>We confirmed earlier reported decrease in sleep duration at the end of pregnancy. As a novel finding, we showed a notable increase in sleep loss during the last month of pregnancy. Various factors were associated with both short sleep and sleep loss, especially multiparity, napping and depressive symptoms.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"310 5","pages":"2541 - 2552"},"PeriodicalIF":2.1,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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