Archives of Gynecology and Obstetrics最新文献

{"title":"DNA methylation and its impact on ovarian steroidogenesis in women with polycystic ovary syndrome: insights from human and animal models.","authors":"Yanyu Zhong, Jin Ding, Fei Xia","doi":"10.1007/s00404-025-08048-w","DOIUrl":"https://doi.org/10.1007/s00404-025-08048-w","url":null,"abstract":"<p><strong>Purpose: </strong>To review how DNA methylation affects ovarian steroidogenesis in polycystic ovary syndrome (PCOS), with evidence from human and animal studies.</p><p><strong>Recent findings: </strong>Women with PCOS show global DNA hypomethylation and altered methylation of ovarian steroidogenic genes, contributing to hyperandrogenism. Animal models of PCOS mirror these epigenetic changes and support a causal role, highlighting DNA methylation signatures as diagnostic biomarkers and therapeutic targets.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-eclampsia, gestational hypertension, and lipid levels during pregnancy: a systematic review and meta-analysis.","authors":"Xiaopei Qin, Fangfang Ai, Qi Zhou, Yadi Zhang, Xiaoyin Yan","doi":"10.1007/s00404-025-08052-0","DOIUrl":"https://doi.org/10.1007/s00404-025-08052-0","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Gestational hypertension (GH) and pre-eclampsia (PE) are common high-risk complications of pregnancy, and are also one of the important causes of global maternal mortality and perinatal mortality. It has been suggested that abnormal lipid metabolism may play a key role in the pathogenesis of GH and PE. However, the results of different studies are controversial and lack of systematic quantitative analysis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Purpose: &lt;/strong&gt;The aim of this study is to evaluate the differences in lipid levels between patients with GH and PE and healthy controls by meta-analysis, and to explore the potential role of abnormal lipid metabolism in the disease.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Design: &lt;/strong&gt;In this study, PubMed, EMBASE, Cochrane Library, CNKI, and other Chinese and English databases were searched. The subjects included in the study were patients with hypertensive disorders during pregnancy (including GH and pre-eclampsia) and healthy controls. To evaluate the differences in triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) levels by systematic review and meta-analysis. Revman software was used to calculate the standardized mean difference (SMD) and its 95% confidence interval (CI). Heterogeneity was evaluated by I&lt;sup&gt;2&lt;/sup&gt; statistic and Q test. Publication bias and sensitivity analysis were also performed.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;(1) A total of 5 studies were included in the meta-analysis of gestational hypertension and lipid profile during pregnancy, including 321 patients with gestational hypertension and 1171 healthy pregnant women. A total of 7 studies were included in the meta-analysis, including 1114 women with gestational hypertension and 32,537 healthy pregnant women. (2) The results showed that HDL levels in patients with gestational hypertension were significantly lower than those in the control group (SMD = - 0.20, 95% CI - 0.35 to - 0.06, P = 0.006), while LDL (SMD = 1.40, 95% CI 1.22 to 1.59, P &lt; 0.00001), TC (SMD = 0.37, 95% CI 0.23 to 0.51, P &lt; 0.00001), and TG (SMD = 0.64, 95% CI 0.50 to 0.79, P &lt; 0.00001) were significantly elevated. (3) HDL levels were significantly lower in the pre-eclampsia group than in the control group (SMD = -0.30 mmol/L, 95% CI - 0.36, - 0.11, P &lt; 0.00001), while LDL (SMD = 0.25, 95% CI 0.18, 0.31, P &lt; 0.00001), TC (SMD = 0.27 mmol/L, 95% CI 0.21, 0.22, P &lt; 0.00001) and TG (SMD = 1.15, 9% CI 0.55, 1.74, P = 0.0002) were significantly increased. Heterogeneity analysis showed moderate-to-high heterogeneity in some indicators (I&lt;sup&gt;2&lt;/sup&gt; range: 56-99%). No significant bias was found in the publication bias test, and the results were robust.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;This study suggests that abnormal lipid metabolism may be an important feature of GH and pre-eclampsia, suggesting that dynamic monitoring of lipid levels has clinical value for early prediction and management of the disease. The decrease of","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of resection distance on vulvar cancer relapse: a retrospective analysis.","authors":"Jan-Philipp Cieslik, Annika Sophia Beerbaum, Tanja Fehm, Monika Hampl","doi":"10.1007/s00404-025-08046-y","DOIUrl":"https://doi.org/10.1007/s00404-025-08046-y","url":null,"abstract":"<p><strong>Objective: </strong>This study evaluates the effect of resection margin distance on disease-free survival (DFS) and (local) recurrence rates in patients with vulvar squamous cell carcinoma (SCC) while assessing the impact of associated factors such as lichen sclerosus (LS) and lymph node metastasis.</p><p><strong>Methods: </strong>A retrospective single-center analysis was conducted on 150 patients treated for vulvar SCC between 2004 and 2014 at University Hospital Düsseldorf. Univariate and multivariate regression analyses were performed to evaluate the impact of clinical and pathological factors on DFS. Additionally, a literature review was conducted to summarize existing evidence on resection margins.</p><p><strong>Results: </strong>The findings suggest that a resection margin exceeding 8 mm does not significantly improve DFS (HR 1.14, CI 1.01-1.28, p = 0.029). LS was significantly associated with recurrence (HR 2.36, CI 1.13-4.91, p = 0.02) and reduced DFS. Univariate analysis identified lymph node metastasis as a significant predictor of DFS; however, this association was not retained in multivariate analysis.</p><p><strong>Conclusion: </strong>Although current guidelines advocate for resection margins >8 mm, our findings suggest that smaller margins may be acceptable in selected patients, particularly those without LS and tumors located near critical structures (e.g., the anus, clitoris, or urethra). These considerations should inform personalized treatment strategies and follow-up care.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative effectiveness and safety of different progestins in combined oral contraceptives: a systematic review and network meta-analysis of randomized controlled trials.","authors":"Binting Li, Xiaotong Xu, Keyi Xu, Jing Ni, Cong Wang, Ting Zhang","doi":"10.1007/s00404-025-08050-2","DOIUrl":"https://doi.org/10.1007/s00404-025-08050-2","url":null,"abstract":"<p><strong>Purpose: </strong>This systematic review and network meta-analysis (NMA) compares four progestins-gestodene (GSD), desogestrel (DSG), drospirenone (DRSP), and levonorgestrel (LNG)-in combined oral contraceptives (COCs) regarding safety, and efficacy for personalized contraceptive selection.</p><p><strong>Methods: </strong>This systematic review, which searched PubMed, Cochrane, Embase and Medline through Jan 28, 2025, to identify published and unpublished randomised controlled trials (RCTs). We assessed the certainty of evidence using the confidence in network meta-analysis (CINeMA) framework. We estimated summary standardised mean differences (SMDs) and odds ratios (ORs) using NMA with random effects by STATA and GeMTC software. The outcomes included breakthrough bleeding (BTB), irregular bleeding (IB), withdrawal bleeding days, pregnancy rates, and adverse events.</p><p><strong>Results: </strong>Eighteen RCTs were included. GSD demonstrated the lowest incidence of BTB and IB (OR 0.41 (0.26, 0.66); OR 0.67 (0.52, 0.86)). For withdrawal bleeding days, DRSP ranked highest (SUCRA 40.1; I² = 27%, p = 0.222), followed by GSD, LNG and DSG. Contraceptive efficacy was highest for DSG (OR 0.74, (0.31-1.73); SUCRA = 51.3%) followed by DRSP and GSD, with LNG being the least effective. Regarding safety, DRSP had the lowest adverse event rate (OR 0.84, 0.60-1.19); SUCRA = 66.9%), followed by LNG and DSG, while GSD was associated with the highest.</p><p><strong>Conclusion: </strong>The four progestogens demonstrate comparable contraceptive efficacy while exhibiting distinct therapeutic advantages in their respective clinical applications. DSG for routine use, GSD for bleeding control, DRSP for minimizing androgenic effects, and LNG for emergency contraception.</p><p><strong>Trial registration: </strong>PROSPERO ID: CRD42024582991.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison between hyperechoic and normo-echoic amniotic membranes in patients with preterm premature rupture of membranes regarding pregnancy outcome.","authors":"Tamer Yehia M Ali, Bassant F Elsayed, Ahmed A Aboelroose, Mohamed M Farrag, Ahmed M Gadallah","doi":"10.1007/s00404-025-08051-1","DOIUrl":"https://doi.org/10.1007/s00404-025-08051-1","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the amniotic membrane echogenicity as a marker of early delivery among pregnant women presenting with leakage of amniotic fluid.</p><p><strong>Methods: </strong>This prospective cohort study was commenced at the Obstetrics and Gynecology Department at Suez Canal University Hospital from March 2023 to March 2024. The study recruited 72 pregnant females aged 20-45 years with singleton pregnancies and presented with preterm leakage of amniotic fluid. The gestational age was between 28 and 37 weeks. The sonographic appearance of the amniotic membranes close to the internal os was evaluated using transvaginal ultrasound. The membranes were classified as hyperechoic when they showed echogenic similarity to the fetal bones (either skull, femur, or pelvic bones) or normo-echoic. The primary outcome measures were the time interval from admission to delivery and the incidence of spontaneous preterm labor.</p><p><strong>Results: </strong>The mean age of patients was 26.06 years old, with mean gestational age at hospital entry 32.47, with no statistically significant difference between hyperechoic and normo-echoic membranes groups. The admission to delivery time was longer among the normo-echoic group (20 days versus 7.1 days, p value = 0.001). The incidence of spontaneous preterm delivery was 71.9% in the hyperechoic membranes group versus 50% in the normo-echoic membrane group.</p><p><strong>Conclusion: </strong>The existence of fetal membranes with increased echogenicity overriding the cervix could anticipate an unavoidable preterm birth in patients diagnosed with preterm premature rupture of membranes.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ovarian damage following surgery for endometriomas, 20 years later: did awareness improve the situation?","authors":"Dalila Invernici, Gianfranco Fornelli, Marco Reschini, Irene La Vecchia, Paola Vigano', Edgardo Somigliana, Paolo Vercellini, Laura Benaglia","doi":"10.1007/s00404-025-08039-x","DOIUrl":"https://doi.org/10.1007/s00404-025-08039-x","url":null,"abstract":"<p><strong>Background: </strong>Early reports from the beginning of this century highlighted significant ovarian damage following laparoscopic stripping of endometriomas. During the last 2 decades, the raised awareness of the possible detrimental effects of surgery has boosted the attention of surgeons on sparing ovarian reserve. Giving this increased consciousness on this issue, in this real-life study, we aimed to assess whether the surgically-related damage to the ovaries has been reduced over the years.</p><p><strong>Materials and methods: </strong>Ovarian reserve was assessed by comparing ovarian response during stimulation for IVF in women who previously underwent surgical treatment for unilateral endometriomas. This study design allows intra-patient comparisons, limiting confounders. In addition, this same design was used in the past and allows therefore to compare findings with those obtained 2 decades ago. The primary aim was the frequency of non-response among operated gonads.</p><p><strong>Results: </strong>One hundred seven female patients with unilateral endometrioma surgery who underwent IVF/ICSI cycles were eligible for the study. The mean ± SD diameter of the excised endometriomas was 46 ± 20 mm. Most women underwent cyst stripping while drainage and ablation was used in only three subjects. The median [IQR] number of follicles in the operated and contralateral gonads was 3 [1-5] and 7 [5-9], respectively (p < 0.001). Absence of follicular growth was observed in 19 operated ovaries (18%, 95% CI 12-26%). The magnitude of the damage remained unchanged, if not worse, when compared to what observed 2 decades ago.</p><p><strong>Conclusions: </strong>Ovarian reserve continues to be significantly compromised after surgery for endometriomas. Further research is urgently needed to better understand the underlying mechanisms and to refine surgical techniques aimed at minimizing this damage.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breast cancer in patients under 40 years: an 11-year retrospective cohort analysis.","authors":"Franziska Ganster, Simone Schrodi, Michael Braun, Christina Seifert, Sven Mahner, Thomas Kolben, Rachel Wuerstlein, Nadia Harbeck, Maximiliane Burgmann","doi":"10.1007/s00404-025-08031-5","DOIUrl":"https://doi.org/10.1007/s00404-025-08031-5","url":null,"abstract":"<p><strong>Introduction: </strong>The number of young breast cancer (BC) patients is increasing in both high- and low-income countries. It is known that this population is at risk for more aggressive tumor phenotypes, larger tumor size at diagnosis and poorer prognosis. It is the aim of this population-based analysis to identify trends of therapy, tumor biology and prognosis during a period of 11 years in young patients under the age of 40.</p><p><strong>Methods: </strong>In this analysis, data of young BC patients (< 40 years) from two breast centers were collected and analysed. The focus was a summary of data regarding tumor phenotypes, treatment, and survival in young BC patients.</p><p><strong>Results: </strong>Out of 11,954 patients with invasive BC who were eligible to the analysis, 781 (6.5%) were younger than 40 years at diagnosis and met the inclusion criteria. The predominant biological subtypes were Luminal B-like (HER2-) and Luminal-A-like, 62.3% were diagnosed with pN0. Noticeably low rates for endocrine therapy and higher rates for chemotherapy could be observed. 10-year overall survival was 87% for the whole cohort. Luminal-B-like (HER2-) and Triple negative tumors had worse outcomes as opposed to the other subtypes.</p><p><strong>Conclusion: </strong>As a conclusion, this 11-year analysis provides valuable insights into the clinical characteristics and treatment outcomes of young breast cancer patients under 40 years of age. The analysis highlights clear outcome differences according to the tumor subtype. These findings underscore the need for personalized treatment approaches and continued follow-up to optimize outcomes for young BC patients.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of virtual reality on pregnant women and fetuses: a systematic review and meta-analysis of randomized controlled trials.","authors":"Xiaopu Shi, Chunguang Liang, Haitao Ren, Chunxia Liao, Na Yue","doi":"10.1007/s00404-025-07971-2","DOIUrl":"https://doi.org/10.1007/s00404-025-07971-2","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Virtual reality (VR), as a low-cost, non-invasive, and highly promising complementary therapeutic approach, has garnered increasing attention for its potential positive impacts on pregnant women, fetuses, and the childbirth process. The aim of this study was to systematically evaluate the specific effects of VR interventions on the psychological status, physiological indicators, and fetal outcomes of pregnant women.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;We conducted a comprehensive literature search in PubMed, EMBASE, MEDLINE, PsycINFO, Web of Science, the Cochrane Library, and Chinese databases (CNKI, Wanfang Data, VIP Database, SinoMed) up to July 2024. The RoB2 tool was used to assess the risk of bias, while the GRADE approach evaluated the certainty of the evidence. RevMan 5.4 was used for data analysis, including subgroup analyses, while meta-regression analyses were performed in Stata 16.0 to explore sources of heterogeneity. Additionally, TSA 0.9.5.10 Beta was utilized to determine the required information size (RIS) for assessing the credibility and conclusiveness of the evidence.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of five randomized controlled trials involving 807 pregnant women were included in this meta-analysis. The findings revealed that VR interventions significantly reduced anxiety levels among pregnant women (MD = - 7.63, 95% CI [- 12.98, - 2.28], Z = 2.8, p = 0.005). Despite substantial heterogeneity observed (I&lt;sup&gt;2&lt;/sup&gt; = 94%, p &lt; 0.001), sensitivity analysis confirmed the robustness of the results, with no single study exerting a significant influence. Subgroup analyses by country of origin further revealed that the impact of VR on reducing anxiety levels among pregnant women differed between Turkey and Spain. Additionally, VR effectively improved systolic blood pressure (MD = - 7.87, 95% CI [- 9.60, - 6.14], Z = 8.92, p &lt; 0.001) and diastolic blood pressure (MD = - 4.80, 95% CI [- 6.21, - 3.38], Z = 6.65, p &lt; 0.001), and significantly decreased maternal heart rate (MD = - 3.9, 95% CI [- 5.52, - 2.28], Z = 4.71, p &lt; 0.001). VR interventions also shortened the duration of Non-Stress Test (NST) (MD = - 5.76, 95% CI [- 10.05, - 1.48], Z = 2.64, p = 0.008) and increased fetal movement accelerations (MD = 1.19, 95% CI [0.82, 1.57], Z = 6.22, p &lt; 0.001). However, the meta-analysis of four studies with a total of 681 pregnant women did not find a statistically significant direct effect on fetal heart rate (MD = 1.25, 95% CI [- 1.38, 3.88], Z = 0.93, p = 0.35), with observed heterogeneity (I&lt;sup&gt;2&lt;/sup&gt; = 73%, p = 0.01).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;This study demonstrates that VR has significant advantages in optimizing the psychological and physiological states of pregnant women, but its direct impact on fetal heart rate is not significant. Further research is needed to explore the potential mechanisms of VR on fetal health, thereby comprehensively evaluating its clinical value as an adjunct to","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Important aspects of the multimodal perioperative management in gynecology.","authors":"Susanne Reuter, Babara Schmalfeldt, Sebastian Haas","doi":"10.1007/s00404-025-08043-1","DOIUrl":"https://doi.org/10.1007/s00404-025-08043-1","url":null,"abstract":"<p><p>Multimodal perioperative management is an integrative, holistic approach to optimizing perioperative patient care. The aim is to accelerate postoperative recovery, minimize complications and increase patient satisfaction. This approach combines various strategies that are tailored to the individual needs of patients. A comprehensive preoperative assessment, in particular preoperative individual risk stratification and perioperative medication management, makes it possible to identify risk factors and take targeted measures. Our overview is intended to provide compact information, particularly for the preoperative setting, and to provide suggestions for practice based on the guideline-oriented summary.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep disorders and psychological comorbidities in women with polycystic ovary syndrome - a cross-sectional study.","authors":"Claire Decrinis, Konstantin Hofmann, Norman Bitterlich, Adrian Singer, Katharina Tropschuh, Serena Lozza-Fiaco, Julia Estermann, Annette Bachmann, Petra Stute","doi":"10.1007/s00404-025-08049-9","DOIUrl":"https://doi.org/10.1007/s00404-025-08049-9","url":null,"abstract":"<p><strong>Purpose: </strong>Polycystic ovary syndrome (PCOS) is a metabolic and hormonal disorder that affects physical and emotional well-being. The aim of this cross-sectional study was to assess associated factors like sleep disturbance, obstructive sleep apnea (OSA), anxiety and depression in a German-speaking population with PCOS.</p><p><strong>Methods: </strong>We designed an anonymous online survey with items from validated questionnaires, including the Hospital Anxiety and Depression Scale (HADS), the Generalized Anxiety Disorder (GAD-7), the Pittsburgh Sleep Quality Index (PSQI) and the STOP-Bang questionnaire to screen for OSA. The survey was mainly distributed via social media in Austria, Germany and Switzerland. Data from 587 questionnaires were analyzed.</p><p><strong>Results: </strong>Based on the STOP Bang questionnaire, 19.5% of women had a high probability for OSA. BMI and insulin resistance were identified as independent associated factors with OSA (both p < 0.001). Overall, the median anxiety score (GAD-7) was in the moderate range (Median 10.0, Interquartile range (IQR) 8.0). According to the HADS, association with moderate to severe anxiety (HADS-A) was 52.0% and with moderate to severe depression (HADS-D) 27.8%. There was a significant positive correlation between HADS-A/ HADS-D and BMI (r = 0.122, (HADS-A)/ r = 0.223 (HADS-D), both p < 0.01). According to the PSQI, 60.5% had mild sleep disturbance and 29.7% had chronic sleep disturbance. Chronic sleep disturbance was associated with anxiety disorders and depression, as well as a high probability of OSA (p < 0.001) after adjustment for age.</p><p><strong>Conclusion: </strong>Our study highlights the probability of depression, anxiety and sleep disorders, including OSA, in women with PCOS and their association with BMI and insulin resistance.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}