DNA甲基化及其对多囊卵巢综合征女性卵巢类固醇生成的影响：来自人类和动物模型的见解

IF 2.5 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Archives of Gynecology and Obstetrics Pub Date : 2025-05-23 DOI:10.1007/s00404-025-08048-w

Yanyu Zhong, Jin Ding, Fei Xia

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引用次数: 0

摘要

目的：回顾DNA甲基化如何影响多囊卵巢综合征（PCOS）卵巢甾体生成，并结合人类和动物研究的证据。最近的研究发现：患有多囊卵巢综合征的女性表现出整体DNA低甲基化和卵巢类固醇基因甲基化改变，导致高雄激素症。多囊卵巢综合征的动物模型反映了这些表观遗传变化，并支持因果关系，突出了DNA甲基化特征作为诊断生物标志物和治疗靶点。

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DNA methylation and its impact on ovarian steroidogenesis in women with polycystic ovary syndrome: insights from human and animal models.

Purpose: To review how DNA methylation affects ovarian steroidogenesis in polycystic ovary syndrome (PCOS), with evidence from human and animal studies.

Recent findings: Women with PCOS show global DNA hypomethylation and altered methylation of ovarian steroidogenic genes, contributing to hyperandrogenism. Animal models of PCOS mirror these epigenetic changes and support a causal role, highlighting DNA methylation signatures as diagnostic biomarkers and therapeutic targets.

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来源期刊

Archives of Gynecology and Obstetrics 医学-妇产科学

CiteScore

4.70

自引率

15.40%

发文量

493

审稿时长

1 months

期刊介绍： Founded in 1870 as "Archiv für Gynaekologie", Archives of Gynecology and Obstetrics has a long and outstanding tradition. Since 1922 the journal has been the Organ of the Deutsche Gesellschaft für Gynäkologie und Geburtshilfe. "The Archives of Gynecology and Obstetrics" is circulated in over 40 countries world wide and is indexed in "PubMed/Medline" and "Science Citation Index Expanded/Journal Citation Report". The journal publishes invited and submitted reviews; peer-reviewed original articles about clinical topics and basic research as well as news and views and guidelines and position statements from all sub-specialties in gynecology and obstetrics.