Archives of Gynecology and Obstetrics最新文献

{"title":"The impact of true knot of umbilical cord on obstetric outcomes—true or not?","authors":"Shay Porat,&nbsp;Doron Kabiri,&nbsp;Gilad Karavani,&nbsp;Hagai Amsalem,&nbsp;Michal Lipschuetz,&nbsp;Joshua I. Rosenbloom","doi":"10.1007/s00404-025-08110-7","DOIUrl":"10.1007/s00404-025-08110-7","url":null,"abstract":"<div><h3>Objectives</h3><p>To quantify the risk of true cord of the umbilical cord for perinatal death and identify additional risk factors.</p><h3>Methods</h3><p>This retrospective study included singleton deliveries between 24 and 42 weeks of gestation that took place between 2003 and 2017 in two medical centers. For patients with true knot, data regarding the number of cord knots as well as the location and number of loops of cord were obtained. The rest of the birth data set comprised the control group. The primary outcome was fetal demise. Secondary outcomes included mode of delivery and perinatal outcomes.</p><h3>Results</h3><p>The final data set included 139,458 deliveries, of which 364 cases (0.26%) comprised the study group (true knot group) and 139,094 cases (99.74%) the control group. Higher rated of unfavorable outcomes were found among cases than controls, including perinatal death, delivery mode, lower Apgar and cord blood umbilical artery pH as well as higher rates of NICU admission and perinatal death. Multivariate analysis showed that true knot of cord (aOR 15.46, 95% CI 9.30–25.70) was a strong predictor of perinatal death. Analysis of predictors of perinatal death within the study group showed that only four or more nuchal loops of cord was an independent predictor (four loops OR 13.40 95% CI 1.12–160.34).</p><h3>Conclusions</h3><p>True knot of the umbilical cord is a strong predictor of perinatal death. Fetuses with true knot of cord and four or more nuchal cord loops are at significantly increased risk of perinatal death. If diagnosed before onset of labor, delivery before 37 weeks may prevent perinatal death.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"312 4","pages":"1175 - 1183"},"PeriodicalIF":2.5,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-025-08110-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144607255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, awareness and recommendation on micronutrition during pregnancy—a survey of healthcare providers","authors":"Anna Elisabeth Hentrich,&nbsp;Doerthe Brueggmann,&nbsp;Eileen Deuster,&nbsp;Anne Kristina Kämpf,&nbsp;Lukas Jennewein,&nbsp;Wiebke Schaarschmidt,&nbsp;Frank Louwen,&nbsp;Samira Catharina Hoock","doi":"10.1007/s00404-025-08111-6","DOIUrl":"10.1007/s00404-025-08111-6","url":null,"abstract":"<div><h3>Background</h3><p>The market for dietary supplements targeting women of reproductive age and pregnant individuals is rapidly expanding. Despite accumulating evidence regarding the benefits of specific micronutrients during pregnancy, there is considerable variability in international and national guidelines, compounded by knowledge gaps among healthcare professionals.</p><h3>Objective</h3><p>This study aimed to assess the knowledge, attitudes, and counseling practices of midwives and physicians in Germany concerning micronutrient supplementation during pregnancy.</p><h3>Methods</h3><p>A cross-sectional online survey was conducted among healthcare professionals in Frankfurt and surrounding regions in April to May 2024. A newly developed 24-item questionnaire was utilized to gather demographic data, assess counseling practices related to micronutrients and knowledge concerning of the roles of folic acid, vitamin D, vitamin B12, and omega-3 fatty acids in fetal development. Data were analyzed using descriptive statistics and Fisher's exact test (<i>p</i> &lt; 0.05).</p><h3>Results</h3><p>Of the 360 individuals who accessed the survey, 107 completed it (33 midwives, 72 physicians). While 96.8% recommended supplementation during pregnancy, only 48.1% rated their knowledge as moderate. Folic acid was most frequently recommended supplement (78.7%), followed by omega-3 fatty acids (68%) and vitamin B12 (notably for vegan diets, 96.1%). Gaps in knowledge were identified, particularly regarding the biochemical forms of folate (34.5% unaware), sources and function of omega-3 fatty acids (20% lacked knowledge), and the role of vitamin B12 in fetal development (19% unaware). Only 41.8% explicitly recommended vitamin D, despite strong evidence of its importance. The majority of respondents expressed a strong interest in further education (91.0%).</p><h3>Conclusion</h3><p>Although healthcare professionals are generally engaged in counseling on prenatal supplementation, substantial knowledge gaps and inconsistent practices persist, particularly regarding newer recommendations beyond folic acid. To improve maternal and fetal health outcomes, there is a pressing need for improved educational initiatives and the broader implementation of tools such as the FIGO nutrition checklist.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"312 4","pages":"1155 - 1161"},"PeriodicalIF":2.5,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-025-08111-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Counseling prior to cfDNA screening: are we giving the right numbers?","authors":"Tania Elger,&nbsp;Jiri Sonek,&nbsp;Natalia Prodan,&nbsp;Markus Hoopmann,&nbsp;Francesca Romana Grati,&nbsp;Karl Oliver Kagan","doi":"10.1007/s00404-025-08108-1","DOIUrl":"10.1007/s00404-025-08108-1","url":null,"abstract":"<div><h3>Objective</h3><p>In this modeled study, we aim to evaluate the test performance of cfDNA screening for trisomy 21, 18, and 13 individually and in combination to help with pre-test counseling.</p><h3>Methods</h3><p>We used the German birth statistics 2023 and calculated the expected number of trisomy 21, 18, and 13 for each maternal age. The number of screen-positive tests (true and false) for trisomy 21, 18, and 13 was estimated based on maternal and gestational age-related risks for the three trisomies. The positive predictive value was calculated for each trisomy individually and in combination according to maternal age. In addition, we applied an uninformative test rate of 1.2%.</p><h3>Results</h3><p>In 2023, 692,730 children were born in Germany and the predicted number of trisomy 21, 18, and 13 fetuses are 2,521.71, 1,084.70, and 344.31, respectively. In total, cfDNA screening in all pregnancies would result in 4,940.9 screen-positive pregnancies (screen-positive rate of 0.7%) and 13,253.69 uninformative tests. Up to 34 years of age, the screen-positive rate would be between 0.3 and 0.5%, but for older women, the screen-positive rate would be between 0.9 and 11.3%. The combined PPV for the three trisomies would be 48.7% in women of less than 20 years of age and increases to 98.8% in women who are 45 years old or older.</p><h3>Conclusion</h3><p>cfDNA screening is an excellent screening test for the most common trisomies. However, counseling prior to the screening test is essential. Our study provides useful numbers which can be used for this purpose.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"312 4","pages":"1145 - 1153"},"PeriodicalIF":2.5,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-025-08108-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for adverse pregnancy outcomes in systemic lupus erythematosus: a meta-analysis and systemic review","authors":"Chen Sun,&nbsp;Ximin Li,&nbsp;Xia Li","doi":"10.1007/s00404-025-08106-3","DOIUrl":"10.1007/s00404-025-08106-3","url":null,"abstract":"<div><h3>Purpose</h3><p>Systemic lupus erythematosus (SLE) is a prominent autoimmune disease highly linked to adverse pregnancy outcomes (APOs). Previous research on the risk factors for APOs in SLE pregnancies has been limited by regional constraints or inadequate sample sizes. Comprehensive systematic reviews on this topic remain scarce. To address these research gaps, we conducted a rigorous meta-analysis and systematic review to elucidate the risk factors for APOs in SLE pregnancies.</p><h3>Methods</h3><p>PubMed, Embase, Web of Science, and the Cochrane Library systematically searched for articles on risk factors for APOs in SLE pregnancy from initiation to March 25, 2025. Pooled odds ratios (ORs) were calculated using fixed-effect or random-effects models based on heterogeneity (I²). Egger’s test was used to assess publication bias.</p><h3>Results</h3><p>A total of 43 studies were reviewed. Patients with hypertension, lupus nephritis (LN), high disease activity, low complements, and antiphospholipid syndrome (APS)/positive antiphospholipid antibodies (aPL) were identified as having a higher risk for adverse pregnancy outcomes (APOs). Risk factors for preterm birth included LN, hypertension, disease flares, high disease activity, and APS/aPL. Risk factors for pregnancy loss included APS/aPL, low complements, disease flares, LN, hypertension, thrombocytopenia, and high disease activity. LN was also associated with an increased risk of intrauterine growth restriction and low birth weight.</p><h3>Conclusions</h3><p>This study identified risk factors for APOs in SLE pregnancies. These findings may support early identification of high-risk patients and guide timely interventions to improve maternal and fetal outcomes.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"312 4","pages":"1025 - 1036"},"PeriodicalIF":2.5,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-025-08106-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144590345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between 22q11.2 deletion syndrome phenotype and deletion location: a meta-analysis","authors":"Jianing Li,&nbsp;Rui Wang,&nbsp;Ling Liu,&nbsp;Jun Zhao,&nbsp;Yue Zhao,&nbsp;Fangfang Liu,&nbsp;Mengyao Zhu,&nbsp;Chunyu Feng,&nbsp;Yueshu Zhao","doi":"10.1007/s00404-025-08041-3","DOIUrl":"10.1007/s00404-025-08041-3","url":null,"abstract":"<div><h3>Background</h3><p>The clinical manifestations of 22q11.2 deletion syndrome (22q11.2 DS) are highly heterogeneous, and the underlying causes of phenotypic variation remain unclear. This study conducted a systematic meta-analysis to evaluate the impact of the deletion position within the 22q11.2 region on phenotypic variability.</p><h3>Methods</h3><p>PubMed, Web of Science, Scopus, Embase, and Cochrane Library databases were searched through 25 September 2024. Literature was screened, and data were extracted based on predefined inclusion and exclusion criteria.</p><h3>Results</h3><p>A total of 17 articles comprising 4107 subjects were included in this study. Among these, 1296 patients presented with congenital heart malformations, while 220 exhibited psychiatric and behavioral abnormalities. 1. Congenital heart malformations: in the central deletion region, congenital heart malformations were significantly associated with the LCR22B-D deletion [OR (BD/CD): 2.74, 95% CI 1.27–5.92, <i>P</i> = 0.01]. 2. Psychiatric and behavioral abnormalities: psychiatric and behavioral abnormalities were significantly associated with smaller typical deletions. Comparisons between the central deletion region and the classic deletion region confirmed a significant association between mental and behavioral abnormalities and LCR22A-B [OR (AB/BD): 6.26, 95% CI 1.16–33.93, <i>P</i> = 0.03].</p><h3>Conclusions</h3><p>Congenital heart malformations are strongly associated with the central deletion region, specifically LCR22B-D. In contrast, psychiatric and behavioral abnormalities are more strongly linked to the LCR22A-B region, suggesting that smaller deletions significantly elevate the risk of mental and behavioral abnormalities.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"312 4","pages":"1013 - 1024"},"PeriodicalIF":2.5,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-025-08041-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144590344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering the influence of pregnancy on rheumatoid arthritis and psoriatic arthritis: insights from musculoskeletal ultrasound dynamics","authors":"Caroline I. Ziegler,&nbsp;Florian Recker,&nbsp;Charlotte Behning,&nbsp;Pia Mielczarek,&nbsp;Brigitte Strizek,&nbsp;Simon M. Petzinna,&nbsp;Valentin S. Schäfer","doi":"10.1007/s00404-025-08107-2","DOIUrl":"10.1007/s00404-025-08107-2","url":null,"abstract":"<div><h3>Objective</h3><p>This prospective observational, hypothesis-generating study aims to investigate the impact of pregnancy on disease activity in rheumatoid arthritis (RA) and psoriatic arthritis (PsA) using musculoskeletal ultrasound (MSUS) and to explore the potential of MSUS to enhance disease monitoring during pregnancy.</p><h3>Methods</h3><p>The study enrolled female participants divided into four groups: pregnant women with RA or PsA, non-pregnant women with RA or PsA, healthy pregnant women, and healthy non-pregnant women. Disease activity was assessed using the Rheumatoid Arthritis Impact of Disease (RAID) score and the Psoriatic Arthritis Impact of Disease (PsAID) score, as well as self-reported questionnaires on health perception. MSUS was performed using the Butterfly iQ portable ultrasound scanner, with synovial hypertrophy and joint effusion assessed via the Advanced Sonography of Large Joints in Rheumatology (aSOLAR) score.</p><h3>Results</h3><p>A total of 105 participants were included: 15 pregnant women with RA or PsA, 30 non-pregnant women with RA or PsA, 30 healthy pregnant women, and 30 healthy non-pregnant women. In pregnant women with RA, conventional disease activity scores and the aSOLAR score showed lower values over the course of pregnancy. In contrast, non-pregnant RA patients generally presented with higher scores in both conventional assessments and the aSOLAR score. Among pregnant PsA patients, conventional scores appeared lower over time, while the aSOLAR score showed comparatively higher values in later pregnancy. Self-reported health perception was more favorable in pregnant RA and PsA patients than in their non-pregnant counterparts. The CRP levels tended to be lower in later pregnancy phases among both RA and PsA patients.</p><h3>Conclusion</h3><p>This pioneering study demonstrates the potential impact of pregnancy on the disease activity of RA and PsA. It emphasizes the exploratory potential of MSUS as an imaging biomarker in the assessment of these conditions during pregnancy. The observed discrepancies between conventional, self-reported diagnostic tools and ultrasound findings support the hypothesis that objective imaging modalities may improve disease monitoring. Our findings warrant further validation in larger, confirmatory studies.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"312 4","pages":"1133 - 1143"},"PeriodicalIF":2.5,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-025-08107-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The treatment of cervical intraepithelial neoplasia grade 2 (HSIL): between active surveillance and surgery—a 10-year monocentric data analysis","authors":"Ulrike Ehlers,&nbsp;Lars Hoischen,&nbsp;Jan Lennart Stalp,&nbsp;Jens Hachenberg,&nbsp;Dhanya Ramachandran,&nbsp;Bianca Brüning,&nbsp;Matthias Jentschke,&nbsp;Peter Hillemanns,&nbsp;Agnieszka Denecke","doi":"10.1007/s00404-025-08097-1","DOIUrl":"10.1007/s00404-025-08097-1","url":null,"abstract":"<div><h3>Purpose</h3><p>In recent years, active surveillance has been introduced as an alternative to excisional treatment in younger women with cervical intraepithelial neoplasia grade 2 (CIN 2) because spontaneous regression rate is high and excisional treatment is associated with an increased risk of preterm birth. However, the potential effect of this conservative approach on the risk of developing cervical cancer has not been evaluated very well.</p><h3>Methods</h3><p>The present study offers a real-life analysis of treatment pathways for patients diagnosed with CIN 2.</p><h3>Results</h3><p>Following CIN 2 diagnosis, 84 cases out of 187 (44.9%) were managed conservatively for at least 7 months and 103 cases (55.1%) were admitted for an excisional procedure LEEP (loop electrosurgical excision procedure). Out of 84 patients observed with a CIN 2 diagnosis, 64 showed persistence of CIN 2 lesion (76.2%), 14 showed spontaneous remission under active surveillance (16.7%), 4 progressed to CIN 3 (4.8%) and 2 to carcinoma (one case of vaginal carcinoma and one case of cervical adenocarcinoma (Supplementary Fig. 1) (2.4%). We observed the regression of CIN 2 in 16.7% of patients on active surveillance and this was statistically significant during the observation period (95% CI 5.72–10.85, <i>p</i> &lt; 0.001) (Supplementary Fig. 3).</p><h3>Conclusion</h3><p>The choice of treatment was strongly associated with HPV typing in our study. Patients with HPV 16 infection underwent surgery more often than patients without HPV 16 infection. The difference in our study was statistically significant (<i>p</i> &lt; 0.001). We observed regression of CIN 2 in 16.7% of patients on active surveillance and this was statistically significant to the observation period (95% CI 5.72–10.85, <i>p</i> &lt; 0.001).</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"312 4","pages":"1125 - 1132"},"PeriodicalIF":2.5,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-025-08097-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term survival in a patient with brain metastases and leptomeningeal disease of breast cancer: a case report of a patient receiving trastuzumab-deruxtecan.","authors":"Patricia von Kroge, Volkmar Müller, Barbara Schmalfeldt, Kerstin Riecke, Leonor Matos, Johann Kornowski, Elena Laakmann","doi":"10.1007/s00404-025-08096-2","DOIUrl":"https://doi.org/10.1007/s00404-025-08096-2","url":null,"abstract":"<p><strong>Introduction: </strong>The incidence of central nervous system (CNS) metastases in breast cancer (BC) patients is increasing, and the prognosis for those with CNS involvement, especially when accompanied by leptomeningeal disease, remains poor. We present a case of long-term survival in a patient with CNS metastases from HER2-positive BC and discuss the treatment considerations in this context.</p><p><strong>Case presentation: </strong>A 54-year-old woman with HER2-positive BC developed CNS metastases, including a highly suspicious finding for leptomeningeal disease, 2 years after initial treatment. At the time of her primary BC diagnosis, she received neoadjuvant chemotherapy, followed by breast surgery, adjuvant radiation, and anti-HER2 targeted therapy. Two years later, she developed parenchymal BM, and brain MRI revealed a leptomeningeal involvement, accompanied by neurological symptoms, including an epileptic episode. She underwent surgical resection and stereotactic radiotherapy for the parenchymal BM, followed by reinduction of trastuzumab as systemic treatment. As the disease progressed and neurological symptoms worsened, the patient received T-DM1. After further cerebral progression in 2021, therapy was switched to Trastuzumab-deruxtecan (T-DXd). Since May 2022, she has received 30 cycles of T-DXd (with a reduced dosage of 4.4 mg/kg since August 2023) without evidence of disease progression.</p><p><strong>Conclusion: </strong>Long-term survival is achievable in patients with CNS metastases from BC, even in the presence of leptomeningeal disease, especially with the use of targeted therapies like T-DXd.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hystrosalpingo-foam sonography with ExEm and lidocaine-based foam gel for detecting tubal occlusion: a diagnostic test accuracy systematic review and meta-analysis.","authors":"Mohamed K A Genedy, Reem Shalata, Marwa El-Difrawy, Abdelrahman A Almetwally, Rahma Sameh Shaheen","doi":"10.1007/s00404-025-08105-4","DOIUrl":"https://doi.org/10.1007/s00404-025-08105-4","url":null,"abstract":"","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of adnexal masses with ultrasonographic parameters and magnetic resonance imaging.","authors":"Cem Erdoğan, Ümmihan Topal, Engin Çelik, İsmail Özdemir","doi":"10.1007/s00404-025-07945-4","DOIUrl":"https://doi.org/10.1007/s00404-025-07945-4","url":null,"abstract":"<p><strong>Purpose: </strong>Adnexal masses (AMs) are commonly seen gynecological problems. Most of the AMs of women in reproductive period are physiologic. A rare but lethal cause of AMs is ovarian cancer. It is important to distinguish benign and malignant AMs. In this study, two scoring systems named \"Evaluation of Different Neoplasms in Adnexa (ADNEX)\" model and \"Ovarian-Adnexal Reporting Data System MR (O-RADS MR)\" were examined in terms of diagnostic performance in distinguishing benign or malignant AMs.</p><p><strong>Methods: </strong>Patients undergone surgery due to AMs were involved in this retrospective study. ADNEX risk model scores and MRI results of patients were re-evaluated for calculating O-RADS MRI scores.</p><p><strong>Results: </strong>284 patients enrolled in this study. ADNEX risk model had a 93.8% (95% CI: 90.9-96.7%) of area under the ROC curve (AUC) for malignancy risk (p < 0.001). O-RADS risk model had a 95.7% (95% CI: 92.8-98.6) of AUC (p < 0.001). When cut-off value was set as 42%, sensitivity and specificity of ADNEX risk model were 87% and 88.6, respectively. Sensitivity and specificity of O-RADS MRI risk scoring system were 93.8% and 93.2 when cut-off value was set as ≥ 4, respectively. AUC values of ADNEX risk model and O-RADS MRI scores were not significantly different in terms of differentiating between benign and malignant cases (p = 0.218).</p><p><strong>Conclusion: </strong>ADNEX risk model and O-RADS MRI score are successful in terms of identifying benign and malign cases for evaluation of AMs. There was no significant difference in the ability of these two methods to distinguish benign and malignant cases.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}