Archives of Gynecology and Obstetrics最新文献

{"title":"Sentinel lymph node biopsy versus pelvic lymphadenectomy for early-stage cervical cancer: a retrospective institutional review","authors":"Tiermes Marina Martin,&nbsp;Cristina Celada Castro,&nbsp;Ariel Glickman,&nbsp;Nuria Carreras,&nbsp;Andrea Valenzuela,&nbsp;Pere Fusté,&nbsp;Adela Saco,&nbsp;Sergi Vidal-Sicart,&nbsp;Aureli Torné,&nbsp;Berta Díaz-Feijoo","doi":"10.1007/s00404-025-08134-z","DOIUrl":"10.1007/s00404-025-08134-z","url":null,"abstract":"<div><h3>Objective</h3><p>To evaluate the oncologic and survival outcomes in patients diagnosed with early-stage cervical cancer who underwent both sentinel lymph node (SLN) and pelvic lymphadenectomy (PLD) compared with those who underwent SLN alone at primary surgery. </p><h3>Methods</h3><p>From 2001 to 2022, women who underwent SLN biopsy for nodal staging were recruited. The group of women who underwent SLN biopsy and PLD (SLN + PLD group) was compared with the group who underwent SLN mapping alone (SLN group).</p><h3>Results</h3><p>210 patients were evaluated (98 and 112 in each group). The overall SLN detection rate was 97.6%. Lymph node involvement was detected in 23 patients (11%), and the rate of positive SLN increased from 6.2 to 11% after final pathological examination. At a median follow-up of 80 months, the recurrence and mortality rates were 6.2 and 2.4%, respectively. The 3-year progression-free survival (PFS) rate was 93.7 and 97.2%, and the overall survival (OS) rate was 98.9 and 99.0% in the SLN + PLD and SLN group, respectively. There were no significant differences in the Kaplan–Meier PFS (<i>p</i> = 0.471; HR 0.66; 95% CI 0.22–2.04) and OS (<i>p</i> = 0.228; HR 0.28; 95% CI 0.03–2.53) curves between the groups.</p><h3>Conclusion</h3><p>Pending further confirmation from prospective trials, SLN biopsy appears to be an effective method of nodal assessment in early-stage cervical cancer. This technique does not appear to increase the risk of recurrence compared with complete PLD in selected patients and may offer a viable, less invasive alternative for accurate nodal staging.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"312 4","pages":"1327 - 1335"},"PeriodicalIF":2.5,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-025-08134-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidative stress biomarkers in fetal growth restriction: a systematic review and meta-analysis","authors":"Lili Li,&nbsp;Longping Zhou,&nbsp;Wenzhong Li,&nbsp;Fengquan Shi,&nbsp;Xufen Feng,&nbsp;Jian Zhuang","doi":"10.1007/s00404-025-08133-0","DOIUrl":"10.1007/s00404-025-08133-0","url":null,"abstract":"<div><h3>Purpose</h3><p>Fetal growth restriction (FGR) affects about 10% of pregnancies and is linked to higher risks of perinatal mortality and long-term health issues, largely due to placental insufficiency and oxidative stress caused by hypoxia and inflammation. This study examines key oxidative stress biomarkers to assess significant differences in FGR versus appropriate for gestational age (AGA) neonates.</p><h3>Methods</h3><p>This meta-analysis reviewed studies up to December analyzing oxidative stress biomarkers in cord blood from FGR versus AGA newborns. Key markers analyzed included malondialdehyde (MDA), superoxide dismutase (SOD), catalase, ischemia-modified albumin (IMA), homocysteine, nitric oxide (NO), and nucleated red blood cells (NRBCs). Standardized mean differences (Cohen’s d) and 95% confidence intervals (CIs) were calculated.</p><h3>Results</h3><p>A total of 48 studies involving 4684 participants were included. MDA levels were significantly higher in FGR infants (d = 0.37, p = 0.01), especially in those with intrauterine growth restriction (IUGR) (d = 0.58, p = 0.02). SOD activity was markedly lower in FGR (d = − 1.98, p &lt; 0.001), most notably in mixed FGR cases (d = − 4.95). Catalase was also reduced (d = − 2.64, p &lt; 0.001), while NRBC (d = 2.24, p &lt; 0.001) and IMA (d = 0.74, p &lt; 0.001) were elevated. Homocysteine and NO levels showed no significant differences.</p><h3>Conclusion</h3><p>FGR is associated with distinct oxidative stress patterns in cord blood. These biomarkers, especially MDA, SOD, catalase, NRBC, and IMA, may hold promise for improving FGR diagnosis.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"312 4","pages":"1063 - 1084"},"PeriodicalIF":2.5,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-025-08133-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative outcomes of oophoropexy techniques in preventing recurrent adnexal torsion","authors":"Yael Yagur,&nbsp;Amit Klein,&nbsp;Lisa Tiosano,&nbsp;Omer Weitzner,&nbsp;Yair Daykan,&nbsp;David Rosen,&nbsp;Zvi Klein,&nbsp;Ron Schonman","doi":"10.1007/s00404-025-08128-x","DOIUrl":"10.1007/s00404-025-08128-x","url":null,"abstract":"<div><h3>Purpose</h3><p>To compare the effectiveness of ovarian ligament plication and ovario-round ligament fixation (\"hot-dog\" technique) in preventing recurrent adnexal torsion.</p><h3>Methods</h3><p>This is a retrospective cohort study performed in the gynecology department, of a university-affiliated tertiary medical center. Women of reproductive age who underwent first fixation following adnexal torsion surgery on the ipsilateral side between 2014 and 2023. The study included a homogenous population with normal ovarian size. Primary outcome was the recurrence rate of adnexal torsion following each fixation technique. Two fixation techniques of ovarian ligament plication and ovario-round ligament fixation were compared.</p><h3>Results</h3><p>A total of 525 adnexal torsion events were reviewed, involving 413 patients. After applying strict inclusion criteria, 38 patients who underwent their first fixation on the ipsilateral side were included in the final analysis. Among them, 27 (71%) underwent ovarian ligament plication, and 11 (29%) underwent ovario-round ligament fixation. Recurrent torsion occurred in 25.9% (7 of 27) of patients in the ovarian ligament plication group, while no recurrences were observed in the ovario-round ligament fixation group. While clinically promising, the difference did not reach statistical significance (<i>p</i> = 0.08). Fixation was also safely performed during pregnancy, primarily in the first trimester, with no postoperative complications observed.</p><h3>Conclusions</h3><p>Ovario-round ligament fixation shows promise as a technique for preventing recurrent torsion with a favorable safety profile. Due to the limited sample size, further larger-scale studies are required to confirm these findings and comprehensively evaluate long-term outcomes.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"312 4","pages":"1317 - 1325"},"PeriodicalIF":2.5,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-025-08128-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between multiple embryo transfers and the incidence of preterm birth and low birth weight: a network meta-analysis","authors":"Linyan Yu,&nbsp;Yan Lyu,&nbsp;Fang Zhang","doi":"10.1007/s00404-025-08136-x","DOIUrl":"10.1007/s00404-025-08136-x","url":null,"abstract":"<div><h3>Purpose</h3><p>In vitro fertilization and embryo transfer (IVF-ET) has become crucial for infertile couples. Previous studies have suggested that multiple ETs are associated with increased risks of preterm birth and low birth weight. The current study aims to investigate this association.</p><h3>Methods</h3><p>PubMed, Cochrane Library, EMBASE, ScienceDirect, and China National Knowledge Infrastructure databases were systematically searched. Network meta-analysis was performed to compare the associations between different numbers of embryo transfers (≥ 2) and the incidence rates of preterm birth and low birth weight. Consistency and inconsistency models were applied to ensure reliability. Frequentist statistical methods used data integration. The surface under the cumulative ranking curve (SUCRA) value was used to rank the risks of preterm birth and low birth weight associated with varying numbers of ETs.</p><h3>Results</h3><p>There was a significant difference in the incidence of low birth weight between the 2-ET and 4-ET groups. The 4-ET group had the highest risks for preterm birth and low birth weight.</p><h3>Conclusion</h3><p>Multiple ETs are associated with increased risks of preterm birth and low birth weight. This study highlights the need for tailored clinical strategies to optimize pregnancy outcomes and mitigate complications.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"312 4","pages":"1049 - 1061"},"PeriodicalIF":2.5,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-025-08136-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of surgical and postoperative pregnancy outcomes between electrotomy and cold instruments for hysteroscopic myomectomy: a single-center, 3-year retrospective study","authors":"Panyu Chen,&nbsp;Danqi Shao,&nbsp;Weie Zhao,&nbsp;Yujie Li,&nbsp;Cong Fang,&nbsp;Lei Jia,&nbsp;Manchao Li","doi":"10.1007/s00404-025-08131-2","DOIUrl":"10.1007/s00404-025-08131-2","url":null,"abstract":"<div><h3>Purpose</h3><p>To compare and analyze surgical outcomes and postoperative pregnancy outcomes between electrotomy and cold instruments for hysteroscopic myomectomy.</p><h3>Methods</h3><p>This study included patients who were diagnosed with submucosal fibroids (FIGO 0-2) in our center and underwent hysteroscopic myomectomy from January 2022 to November 2024. Hysteroscopic myomectomy was performed by either bipolar system or cold instruments. Surgical and postoperative pregnancy outcomes were recorded and analyzed.</p><h3>Results</h3><p>A total of 36 patients underwent hysteroscopic myomectomy at our center during the 3-year period, 21 in the cold instruments group and 15 in the electrotomy group. The mean age of the patients in the cold instruments group was significantly higher than that of the electrotomy group (39.00 ± 5.18 vs 35.20 ± 3.45, <i>P</i> = 0.019). In the electrotomy group, four patients found residual fibroids and required a second surgery. The incidence of residual fibroids and a second procedure were significantly higher than those in the cold instruments group (4/15(26.67%) vs 0, <i>P</i> = 0.023). The postoperative biochemical pregnancy rate and clinical pregnancy rate were higher in patients in the cold instruments group, but the difference was not statistically significant (14/21 (66.67%) vs 8/15 (53.33%), <i>P</i> = 0.644; 10/21(47.62%) vs 5/15(33.33%), <i>P</i> = 0.607).</p><h3>Conclusion</h3><p>Cold instruments for hysteroscopic myomectomy seem to be a safe and feasible surgical procedure. It has an advantage over electrotomy in terms of complete removal of submucosal fibroids. Moreover, cold instruments for hysteroscopic myomectomy have no electrothermal damage to normal endometrium, which is favorable for pregnancy as soon as possible after surgery.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"312 4","pages":"1309 - 1316"},"PeriodicalIF":2.5,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-025-08131-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single frozen-thawed blastocyst derived from poor-grade Day 3 embryo is not associated with adverse neonatal outcomes: a retrospective cohort study","authors":"Danjun Li,&nbsp;Shutian Jiang,&nbsp;Meng Ma,&nbsp;Wenzhi Li,&nbsp;Zhijie Hu,&nbsp;Xuefeng Lu,&nbsp;Qifeng Lyu","doi":"10.1007/s00404-025-08122-3","DOIUrl":"10.1007/s00404-025-08122-3","url":null,"abstract":"<div><h3>Purpose</h3><p>To investigate whether single frozen-thawed blastocyst transfers derived from poor-grade Day 3 embryos influence neonatal outcomes.</p><h3>Methods</h3><p>This retrospective cohort study conducted in a tertiary academic medical center included all the live-born singletons (<i>n</i> = 3156) in vitrified-warmed single blastocyst transfer cycles from January 2013 to November 2023, which were divided into the poor-grade group (<i>n</i> = 2432) and the high-grade group (<i>n</i> = 724) based on the embryo grade on Day 3. Propensity score matching (PSM) analysis and multivariate regression analysis were used to explore the association between the embryo grade on Day 3 and neonatal outcomes.</p><h3>Results</h3><p>After PSM, the baseline characteristics were all comparable between the two groups. There was a significant gender difference between the two groups (<i>P</i> = 0.004), while there were no differences in the mode of delivery, very preterm birth, preterm birth, very low birth weight, low birth weight, macrosomia, small for gestational age, large for gestational age, or congenital malformations (<i>P</i> &gt; 0.05). After multivariate regression analysis, it was shown that the proportion of male neonates born through blastocyst transfer derived from poor-grade Day 3 embryos was considerably higher (aOR 0.710, 95%CI 0.570–0.890; <i>P</i> = 0.003), whereas no differences were found in other outcome variables (<i>P</i> &gt; 0.05).</p><h3>Conclusion</h3><p>In the single frozen-thawed blastocyst transfer cycle, the poor-grade embryo on Day 3 is associated with a higher proportion of male neonates, but not with adverse neonatal outcomes.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"312 4","pages":"1295 - 1307"},"PeriodicalIF":2.5,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-025-08122-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Making sense of fundal pressure: A qualitative study on women’s experiences of a non-evidence-based yet commonly practiced intervention","authors":"Mi-Ran Okumu,&nbsp;Lisa Bach,&nbsp;Ute Karbach,&nbsp;Lorna McKee,&nbsp;Florian Recker,&nbsp;Lissa Haid-Schmallenberg,&nbsp;Arno Stöcker,&nbsp;Anna Volkert,&nbsp;Nadine Scholten","doi":"10.1007/s00404-025-08130-3","DOIUrl":"10.1007/s00404-025-08130-3","url":null,"abstract":"<div><h3>Introduction</h3><p>Fundal pressure (FP) during second stage of labour has been discussed controversially. The intervention involves pressure to the uppermost part of the uterus to assist vaginal birth. While evidence is lacking, women report differing experiences from violent and traumatic to positive and helpful. This paper examines the experience of FP from the perspective of women without evaluating the intervention itself.</p><h3>Methods</h3><p>The informed grounded theory study included 12 experiences of FP. The inclusion criteria were hospital births with application of FP no longer than 12 months ago. Inductively generated codes were aligned with a previously developed theoretical model on perception formation during obstetric situations.</p><h3>Results</h3><p>The women’s appraisal of FP was determined by the level of perceived comprehensibility (understanding of situation and intervention) and manageability (ability to cope) as well as respective subcategories. Depending on the depictions of the participants, we determined six FP experiences as positive, three as neutral and three as negative. In all classifications, there were cases of low comprehensibility largely tied to brief medical explanations given the urgency of the situations. Regarding manageability, positive experiences were connected to high, neutral experiences to moderate, and negative experiences to low levels of manageability.</p><h3>Conclusion</h3><p>Our study indicates that women’s appraisal of FP is determined by the level of comprehensibility and particularly manageability. In light of the controversies around FP, we do not take position whether FP should be applied or banned but conclude that if FP is applied, women’s comprehensibility and manageability need to be safeguarded.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"312 4","pages":"1277 - 1286"},"PeriodicalIF":2.5,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-025-08130-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevalence and clinical relevance of cervical abnormalities after an amputation of the cervix as part of prolapse surgery: a cross-sectional study","authors":"Véronique V. van Cooten,&nbsp;Dennis van Hamont,&nbsp;Albert G. Siebers,&nbsp;Luthy Alcalá,&nbsp;Ruud L. M. Bekkers,&nbsp;Leonie Speksnijder","doi":"10.1007/s00404-025-08135-y","DOIUrl":"10.1007/s00404-025-08135-y","url":null,"abstract":"<div><h3>Purpose</h3><p>To examine the safety of omitting routine histopathological examination by determining the prevalence of cervical pathology in women after cervical amputation as part of pelvic organ prolapse (POP) surgery without pre-existing indication for histology and the necessity of additional treatment.</p><h3>Methods</h3><p>A cross-sectional study was performed using data of women who underwent cervical amputation as part of POP without pre-existing indication for histopathological examination, obtained from Palga, the Dutch nationwide pathology databank, between January 1991 and January 2022.</p><h3>Main outcome measures</h3><p>The prevalences of the following histological diagnoses were determined: Cervical Intraepithelial Neoplasia (CIN I–III), adenocarcinomas in situ (AIS), cervical carcinomas, and other malignancies.</p><h3>Results</h3><p>In total, 14.887 patients were included in this study, with a median age of 61.4 years (SD = 11.7). The prevalence of CIN II+ lesions was 6.9 [95%-CI 5.6, 8.3] per 1000 women, while one cervical carcinoma (6.7 [95%-CI −0.6, 19.9] per 100.000 women) was reported (stage IA1 microinvasive squamous cell carcinoma).</p><h3>Conclusion</h3><p>This study found a prevalence of 0.7% for CIN II+ incidental findings in women undergoing amputation of the cervix as part of POP surgery. No additional treatments were required after the final histopathological results.</p><p>The decision to omit routine histopathological examination could potentially be safe, offering the prospect of reduced healthcare costs and environmental impact. Healthcare professionals should individually assess the risks and benefits of omitting and/or replacing routine histopathological examination.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"312 4","pages":"1287 - 1294"},"PeriodicalIF":2.5,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-025-08135-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the effect of simple follicular cysts on clinical pregnancy outcomes in in-vitro fertilization cycles","authors":"Begum Ertan,&nbsp;Ufuk Atlihan,&nbsp;Cemal Posaci","doi":"10.1007/s00404-025-08132-1","DOIUrl":"10.1007/s00404-025-08132-1","url":null,"abstract":"<div><h3>Purpose</h3><p>To compare clinical pregnancy outcomes between patients with and without cysts observed on baseline ultrasound at the beginning of an in-vitro fertilization (IVF) cycle and to provide guidance on how to manage IVF cycles in patients presenting with simple follicular cysts.</p><h3>Methods</h3><p>Patients who were admitted to the hospital aged 18–45 years and diagnosed as having follicle cysts measuring &gt; 10 mm at the beginning of an IVF cycle, were included in the study as the cyst group. The control group was selected in a way that would be compatible with the age of the cyst group and the causes of infertility. Cyst diameters were also divided into three groups as 10–15 mm, 16–20 mm, and &gt; 21 mm. The patients’ anti-mullerian hormone levels, the presence of cysts, serum estradiol, luteinizing hormone and progesterone levels, the number of oocytes retrieved, the number of embryos, the fertilization rate, the clinical pregnancy outcome, and the live birth rate were evaluated.</p><h3>Results</h3><p>There was no statistically significant difference between the cyst and control groups in terms of clinical pregnancy, live birth rates, and miscarriage rates. Total antral follicle count was significantly higher in the clinical pregnancy group than in the non-pregnancy group. In the cyst group, the mean serum E2 value on the day of ovulation trigger day was significantly higher in the non-cycle cancellation group than in the cycle cancellation group. The cyst diameter values were analyzed in relation to cycle cancellation using ROC analysis and the cut-off value was determined as 14 mm, calculated based on the Youden Index.</p><h3>Conclusion</h3><p>In follicles &lt; 14 mm, cycles can be started without hesitation. Although pregnancy rates tend to decline in patients with cysts ≥ 21 mm, the difference remains statistically insignificant. Prospective randomized controlled studies with a high number of patients are needed on this subject.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"312 4","pages":"1267 - 1276"},"PeriodicalIF":2.5,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-025-08132-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the quality of life and influencing factors among perimenopausal women","authors":"Xiangrong Liu,&nbsp;Xiumin Zhang,&nbsp;Dianhui Wang,&nbsp;Jing Zhou,&nbsp;Yu Li","doi":"10.1007/s00404-025-08116-1","DOIUrl":"10.1007/s00404-025-08116-1","url":null,"abstract":"<div><h3>Purpose</h3><p>Perimenopause, the transitional phase preceding menopause, is characterized by hormonal fluctuations causing physical, psychological, and sexual symptoms collectively known as perimenopausal syndrome. These symptoms can substantially impair quality of life (QoL), particularly in the context of an aging global population. This study aimed to evaluate the QoL among perimenopausal women and identify factors influencing it.</p><h3>Methods</h3><p>This cross-sectional study was conducted at the Second Hospital of Shandong University from January 2022 to December 2023. A total of 387 perimenopausal women were selected by convenience sampling. Data were collected using MENQOL, PSQI, IPAQ-L, SAS, and SDS scales. Statistical analyses included Pearson correlation, one-way ANOVA, rank-sum tests, and stepwise multivariate linear regression (P &lt; 0.05).</p><h3>Results</h3><p>The mean MENQOL score was 51.59 ± 30.15, indicating moderate overall quality-of-life impairment. The mean PSQI score was 9.97 ± 5.89; 70.54% of participants had poor sleep quality. Anxiety symptoms were present in 58.9% of participants, and depressive symptoms in 68.7%. Leisure-time physical activity was low (median: 396 MET-min/week), while sedentary behavior was high (mean: 1598 ± 903 min/week). Correlation analysis showed total MENQOL scores to be positively associated with PSQI (r = 0.579, P &lt; 0.01), SAS (r = 0.096, P &gt; 0.05), and SDS scores (r = 0.059, P &gt; 0.05), and negatively associated with sleep duration (r = − 0.380, P &lt; 0.01). Work-related physical activity was also positively associated with MENQOL scores (r = 0.144, P &lt; 0.01). Multivariate regression identified the following independent predictors of poorer quality of life: poorer sleep quality, shorter sleep duration, higher work-related physical activity, presence of anxiety or depression, older age, and comorbid conditions.</p><h3>Conclusion</h3><p>The QoL of perimenopausal women is affected by a multifactorial interplay of lifestyle behaviors, psychological status, and chronic health conditions, highlighting the importance of early screening and tailored interventions, particularly those addressing sleep disturbances, mental health, and appropriate physical activity.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"312 4","pages":"1253 - 1265"},"PeriodicalIF":2.5,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-025-08116-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}