Archives of Gynecology and Obstetrics最新文献

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Pemphigoid gestationis: a rare pregnancy-associated autoimmune blistering disorder. 类天疱疮妊娠:一种罕见的与妊娠相关的自身免疫性水泡疾病。
IF 2.5 3区 医学
Archives of Gynecology and Obstetrics Pub Date : 2025-08-19 DOI: 10.1007/s00404-025-08146-9
Sivan Farladansky-Gershnabel, Gil Shechter-Maor, Tal Biron-Shental
{"title":"Pemphigoid gestationis: a rare pregnancy-associated autoimmune blistering disorder.","authors":"Sivan Farladansky-Gershnabel, Gil Shechter-Maor, Tal Biron-Shental","doi":"10.1007/s00404-025-08146-9","DOIUrl":"10.1007/s00404-025-08146-9","url":null,"abstract":"","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment and survival of early non-metastatic breast cancer in men: real world data from a population-based registry. 男性早期非转移性乳腺癌的治疗和生存:来自基于人群登记的真实世界数据。
IF 2.5 3区 医学
Archives of Gynecology and Obstetrics Pub Date : 2025-08-18 DOI: 10.1007/s00404-025-08139-8
D Jakob, D Dannehl, H Endres, L Jansen, S Hermann, A D Hartkopf, S Huwer, L Jung, O Thijssen, I Juhasz-Böss, F A Taran
{"title":"Treatment and survival of early non-metastatic breast cancer in men: real world data from a population-based registry.","authors":"D Jakob, D Dannehl, H Endres, L Jansen, S Hermann, A D Hartkopf, S Huwer, L Jung, O Thijssen, I Juhasz-Böss, F A Taran","doi":"10.1007/s00404-025-08139-8","DOIUrl":"https://doi.org/10.1007/s00404-025-08139-8","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to characterize a cohort of male patients with non-metastatic breast cancer, specifically focusing on tumor characteristics, treatment strategies, and determinants of overall survival.</p><p><strong>Methods: </strong>Data for this study were obtained from the Baden-Württemberg Cancer Registry, encompassing male patients diagnosed with breast cancer between 2015 and 2023. A total of 470 patient records were included. We described patient and tumor characteristics using descriptive statistics. Overall survival was analyzed using Kaplan-Meier survival curves and Cox proportional hazards regression models to identify significant determinants.</p><p><strong>Results: </strong>In our cohort of male patients with non-metastatic breast cancer, luminal subtype was the predominant tumor biology, accounting for 90% of cases. HER2-positive tumors were observed in 9% of patients, while triple-negative tumors were rare, with only four cases identified. Regarding tumor staging, 81.7% of patients were diagnosed at T1 or T2 stages. However, a substantial proportion (48.7%) presented with clinically involved lymph nodes, and 27.1% were diagnosed at UICC stage III. The five-year overall survival rate for the cohort was 73.7%. Treatment analysis revealed that 86% of patients underwent surgical intervention. Mastectomy combined with sentinel lymph node dissection was the most frequent surgical procedure, performed in 50.6% of cases. Adjuvant radiotherapy was administered to 72.8% of patients. Cox regression analysis identified age, nodal status, and surgical intervention as significant determinants of overall survival.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prediction model for intrapartum cesarean delivery among women with gestational diabetes mellitus. 妊娠期糖尿病妇女产时剖宫产的预测模型。
IF 2.5 3区 医学
Archives of Gynecology and Obstetrics Pub Date : 2025-08-12 DOI: 10.1007/s00404-025-08147-8
Itamar Gilboa, Daniel Gabbai, Emmanuel Attali, Liran Hiersch, Anat Lavie, Yariv Yogev
{"title":"Prediction model for intrapartum cesarean delivery among women with gestational diabetes mellitus.","authors":"Itamar Gilboa, Daniel Gabbai, Emmanuel Attali, Liran Hiersch, Anat Lavie, Yariv Yogev","doi":"10.1007/s00404-025-08147-8","DOIUrl":"https://doi.org/10.1007/s00404-025-08147-8","url":null,"abstract":"<p><strong>Purpose: </strong>To identify risk factors and to develop a predictive model for cesarean delivery (CD) in women with gestational diabetes mellitus (GDM).</p><p><strong>Study design: </strong>A retrospective cohort study, in a single university-affiliated tertiary medical center, was performed. All women with GDM and a singleton pregnancy who had a trial of labor between 2011 and 2023 were included. Women who chose an elective CD, those with pre-gestational diabetes, estimated fetal weight ≥ 4000 g, previous CD, and those with non-viable fetuses were excluded. Maternal characteristics of women who delivered vaginally were compared to those who underwent an intrapartum CD. Factors associated with CD were examined using univariate and multivariate analysis. A score was developed to predict the need for intrapartum CD. A receiver operating characteristic curve (ROC) was utilized for the model. Internal validation was performed using a 70/30 train-test split, with model performance evaluated on the validation set using ROC analysis. The main outcome was an unplanned intrapartum CD.</p><p><strong>Results: </strong>Overall, 11,305 women were included; of them 676 (6.0%) underwent intrapartum CD. Several risk factors were identified, including maternal age ≥ 40 years, body mass index > 30kg/m<sup>2</sup>, maternal height < 1.6m, in vitro fertilization, gestational weight gain > 15kg, nulliparity, induction of labor, oxytocin use during labor, preeclampsia, meconium-stained amniotic fluid, and birthweight ≥ 3,500g. Pharmacologically treated GDM was not associated as a risk factor. Epidural anesthesia was associated with reduced risk for intrapartum CD. A prediction score model has reached a predictive performance with an AUC of 0.807 (95%CI 0.79-0.83, p < 0.001). On internal validation using the 30% hold-out cohort, the model maintained strong performance with an AUC of 0.788 (95% CI 0.76-0.82).</p><p><strong>Conclusion: </strong>Several maternal and intrapartum factors were associated with intrapartum cesarean delivery in women with GDM. A prediction model based on these factors may help identify high-risk patients and support delivery planning.</p>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial Expression of Concern: Comparative study of titrated oral misoprostol solution and vaginal dinoprostone for labor induction at term pregnancy. 编辑关注的表达:滴定口服米索前列醇溶液和阴道迪诺前列酮用于足月妊娠引产的比较研究。
IF 2.5 3区 医学
Archives of Gynecology and Obstetrics Pub Date : 2025-08-09 DOI: 10.1007/s00404-025-08109-0
Xiu Wang, Aijun Yang, Qingyong Ma, Xuelan Li, Li Qin, Tongqiang He
{"title":"Editorial Expression of Concern: Comparative study of titrated oral misoprostol solution and vaginal dinoprostone for labor induction at term pregnancy.","authors":"Xiu Wang, Aijun Yang, Qingyong Ma, Xuelan Li, Li Qin, Tongqiang He","doi":"10.1007/s00404-025-08109-0","DOIUrl":"https://doi.org/10.1007/s00404-025-08109-0","url":null,"abstract":"","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144803307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Obstacles in genetic testing for germline BRCA1/2 pathogenic mutations in patients with primary breast and ovarian cancer in Switzerland 瑞士原发性乳腺癌和卵巢癌患者生殖系BRCA1/2致病突变基因检测的障碍
IF 2.5 3区 医学
Archives of Gynecology and Obstetrics Pub Date : 2025-08-09 DOI: 10.1007/s00404-025-08138-9
Christian Braun, Lucie Krautova, Kathrin Schwedler, Corina Christmann, Christine Brambs
{"title":"Obstacles in genetic testing for germline BRCA1/2 pathogenic mutations in patients with primary breast and ovarian cancer in Switzerland","authors":"Christian Braun,&nbsp;Lucie Krautova,&nbsp;Kathrin Schwedler,&nbsp;Corina Christmann,&nbsp;Christine Brambs","doi":"10.1007/s00404-025-08138-9","DOIUrl":"10.1007/s00404-025-08138-9","url":null,"abstract":"<div><h3>Purpose</h3><p>Approximately 5–10% of breast and up to 25% of ovarian cancer cases are hereditary, predominantly associated with germline BRCA1/2 pathogenic variants. Identifying these mutations is essential for personalized treatment, prevention strategies, and cascade testing in families. However, integrating genetic testing into routine care faces substantial barriers globally and within Switzerland.</p><h3>Methods</h3><p>This retrospective, quantitative study analyzed 209 patients treated for non-mucinous ovarian carcinoma or primary breast cancer at the Women’s Cantonal Hospital, Lucerne (2017–2022). All patients met Swiss clinical (SAKK) criteria for genetic testing, and recommendations for counseling were documented. Data were collected via anonymized questionnaires evaluating demographics, counseling experiences, emotional responses, and testing barriers. Statistical analyses examined factors influencing counseling uptake, including timing, referral source, education, and informational resources.</p><h3>Results</h3><p>Out of 73 respondents (32.6% response rate), 70 questionnaires were analyzed. Acceptance of genetic counseling was 81.4%. Recommendations by gynecologists significantly enhanced uptake (<i>p</i> = 0.002), especially when provided postoperatively or at diagnosis (<i>p</i> = 0.011). Higher education levels (<i>p</i> = 0.009) and prior informational materials (<i>p</i> = 0.014) positively influenced acceptance. Emotional responses differed, with breast cancer patients reporting more fear, whereas ovarian cancer patients reported greater curiosity. Family involvement supported patient engagement, while perceptions of minimal personal benefit and family disinterest were common reasons for declining<b>.</b></p><h3>Conclusion</h3><p>Timely, well-communicated recommendations and informational resources significantly improve genetic counseling uptake among breast and ovarian cancer patients. Addressing systemic and patient-specific barriers will enhance equitable access, optimize targeted therapies and preventive strategies, and should be supported by national registries, qualitative research, and digital integration.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"312 4","pages":"1365 - 1373"},"PeriodicalIF":2.5,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-025-08138-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144803308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Value of serum uric acid in a risk prediction model for postmenopausal osteoporosis 血清尿酸在绝经后骨质疏松症风险预测模型中的价值。
IF 2.5 3区 医学
Archives of Gynecology and Obstetrics Pub Date : 2025-08-09 DOI: 10.1007/s00404-025-08119-y
Bingquan Li, Yongheng Ye, Jianfeng Li
{"title":"Value of serum uric acid in a risk prediction model for postmenopausal osteoporosis","authors":"Bingquan Li,&nbsp;Yongheng Ye,&nbsp;Jianfeng Li","doi":"10.1007/s00404-025-08119-y","DOIUrl":"10.1007/s00404-025-08119-y","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the potential role of serum uric acid (UA) in risk stratification for postmenopausal osteoporosis (PMOP) and to establish an accessible risk prediction model that can aid in early screening and diagnosis.</p><h3>Methods</h3><p>We retrospectively enrolled 295 postmenopausal women who underwent dual-energy X-ray absorptiometry (DXA) at Zhuhai Hospital affiliated with Jinan University from July 2021 to July 2023. Participants were divided into a PMOP group (<i>T</i>-score &lt; –2.5; <i>n</i> = 125) and a control group (<i>T</i>-score ≥ –2.5; <i>n</i> = 170). Clinical and laboratory data were collected, including markers of inflammation, renal function, and uric acid levels. Univariable and multivariable logistic regression analyses identified independent risk factors for PMOP. A nomogram was constructed based on the final logistic regression model and evaluated for discrimination and calibration using receiver operating characteristic (ROC) curves, calibration curves, and the concordance index (C-index).</p><h3>Results</h3><p>The PMOP group exhibited significantly higher mean values of age, alkaline phosphatase (ALP), neutrophil count (NEU), monocyte count (MO), monocyte-to-lymphocyte ratio (MLR), and the systemic immune-inflammation index (SII), while demonstrating significantly lower lymphocyte counts (LYM), height, OSTA scores, and albumin (ALB). Serum UA values were slightly lower in the PMOP group than in the control group. Multivariable logistic regression yielded a prediction model incorporating ALB, ALP, MLR, and UA. The area under the ROC curve (AUC) for this model was 0.781 (95% CI: 0.682–0.879). The calibration curve aligned well with the ideal reference line, and the C-index was 0.779 (95% CI: 0.728–0.831).</p><h3>Conclusion</h3><p>Serum uric acid may have a contributory role in risk stratification for PMOP when combined with key clinical and laboratory markers. This nomogram-based model demonstrates moderate predictive performance; future large-scale multicenter prospective cohorts are warranted to validate these findings and to refine the model by accounting for potential confounding factors such as medication use, dietary intake, and lifestyle habits.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"312 4","pages":"1375 - 1382"},"PeriodicalIF":2.5,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-025-08119-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144803309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors assocıated with increased risk of urge incontinence after trans-obturator tape 经闭孔胶带后急迫性尿失禁风险增加的因素assocıated。
IF 2.5 3区 医学
Archives of Gynecology and Obstetrics Pub Date : 2025-08-05 DOI: 10.1007/s00404-025-08142-z
Sezgin Yeni, Ahmet Jakal
{"title":"Factors assocıated with increased risk of urge incontinence after trans-obturator tape","authors":"Sezgin Yeni,&nbsp;Ahmet Jakal","doi":"10.1007/s00404-025-08142-z","DOIUrl":"10.1007/s00404-025-08142-z","url":null,"abstract":"<div><h3>Purpose</h3><p>Urge urinary incontinence (UUI) is a common postoperative symptom after the trans-obturator tape (TOT) procedure, often adversely affecting patients’ quality of life (QoL). This study aimed to identify the risk factors that increase the likelihood of UUI, with the goal of addressing these factors to enhance patients’ QoL.</p><h3>Material and Method</h3><p>This retrospective analysis included 365 women diagnosed with pure stress incontinence who underwent the TOT procedure from 2015 to 2023. Of these, 112 patients who developed UUI were classified as Group 1, while 253 patients without UUI were designated as Group 2. The study examined factors such as age, body mass index (BMI), number of births, delivery types, menopausal status, follow-up duration, recurrence of stress incontinence, meatal stenosis, post-void residual (PVR), Burch operation rate, and instances of recurrent UTIs. Quality of Life was assessed using the Incontinence QoL (I-QoL) questionnaire. Urge symptoms were evaluated through both a bladder diary (BD) and the Overactive Bladder Symptom Score (OABSS) questionnaire.</p><h3>Results</h3><p>Risk factors, including menopause (p = 0.013), increased BMI (p = 0.001), elevated PVR (p = 0.019), meatal stenosis (p = 0.038), and advanced age (p = 0.045), were significantly more prevalent in Group 1 compared to Group 2. Additionally, Group 1 had considerably lower I-QoL scores across all domains, suggesting substantial psychosocial and functional impairment (p &lt; 0.001).</p><h3>Conclusion</h3><p>UUI following the TOT procedure is influenced by various modifiable and non-modifiable factors. Through comprehensive pre-operative and postoperative evaluations, high-risk patients can be identified, potentially reducing UUI symptoms and improving their QoL.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"312 4","pages":"1345 - 1352"},"PeriodicalIF":2.5,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-025-08142-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Second stage of labor beyond 4 h in nulliparous patients with epidural analgesia: implications and outcomes—a retrospective cohort 无产患者硬膜外镇痛超过4小时的第二产程:影响和结果-回顾性队列。
IF 2.5 3区 医学
Archives of Gynecology and Obstetrics Pub Date : 2025-08-05 DOI: 10.1007/s00404-025-08141-0
Gal Cohen, Michal Kovo, Hila Shalev-Ram, Chen Key-Segal, Gil Shechter-Maor, Tal Biron-Shental, Hanoch Schreiber
{"title":"Second stage of labor beyond 4 h in nulliparous patients with epidural analgesia: implications and outcomes—a retrospective cohort","authors":"Gal Cohen,&nbsp;Michal Kovo,&nbsp;Hila Shalev-Ram,&nbsp;Chen Key-Segal,&nbsp;Gil Shechter-Maor,&nbsp;Tal Biron-Shental,&nbsp;Hanoch Schreiber","doi":"10.1007/s00404-025-08141-0","DOIUrl":"10.1007/s00404-025-08141-0","url":null,"abstract":"<div><h3>Purpose</h3><p>To evaluate the obstetric outcomes in nulliparas with epidural who exceeded the 95th percentile duration of 4 h.</p><h3>Methods</h3><p>This retrospective cohort included all term, singleton deliveries of nulliparas with epidural analgesia and second stage duration &gt; 3 h, from 2014 to 2021. Maternal and neonatal outcomes were evaluated by comparing second stage duration 3–4 h vs. &gt; 4 h.</p><h3>Results</h3><p>A total of 2,798 deliveries were included, with 2273 in the 3–4 h group (mean duration 3.42 ± 0.28 h) and 525 in the &gt; 4 h group (mean duration 4.38 ± 0.42 h). Compared to the 3–4 h group, the &gt; 4 h group had lower rate of vaginal deliveries (80.4% vs. 93%, p &lt; 0.001), relatively higher rate of vacuum extractions (VE) (56.0% vs. 42.4%, p &lt; 0.001) and higher rate of cesarean deliveries (CD) (19.6% vs. 7.0%, p &lt; 0.001). The &gt; 4 h group had higher rates of macrosomia and large for gestational age birthweights (7.0% vs. 4.0%, p &lt; 0.003 and 11.8% vs. 8.9%, p = 0.039, respectively). Shoulder dystocia, neonatal subgaleal hematoma and failed VE were more common in the &gt; 4 h group (2.7% vs. 1.1%, 9.0% vs. 3.3% and 4.4% vs. 1.0%, respectively, p &lt; 0.01 for all), as well as the composite neonatal trauma outcome (11.2% vs. 4.1%, p &lt; 0.001). Multivariable logistic regression adjusted for confounders including obesity, hypertensive disorders, diabetes, macrosomia and delivery mode, revealed that a duration of &gt; 4 h was associated with increased risks of shoulder dystocia, subgaleal hematoma and failed VE.</p><h3>Conclusion</h3><p>Most patients achieve vaginal delivery even after a duration of &gt; 4 h. However, it is associated with increased risks of neonatal birth trauma and failed VE<b>.</b></p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"312 4","pages":"1353 - 1363"},"PeriodicalIF":2.5,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-025-08141-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endometriosis as a risk factor: impact on IVF outcomes and reproductive parameters: a systematic review and meta-analysis 子宫内膜异位症作为一个危险因素:对IVF结果和生殖参数的影响:一项系统回顾和荟萃分析。
IF 2.5 3区 医学
Archives of Gynecology and Obstetrics Pub Date : 2025-08-01 DOI: 10.1007/s00404-025-08137-w
Liting Liao, Zhijian Pan, Yanjuan Li
{"title":"Endometriosis as a risk factor: impact on IVF outcomes and reproductive parameters: a systematic review and meta-analysis","authors":"Liting Liao,&nbsp;Zhijian Pan,&nbsp;Yanjuan Li","doi":"10.1007/s00404-025-08137-w","DOIUrl":"10.1007/s00404-025-08137-w","url":null,"abstract":"<div><h3>Background</h3><p>Endometriosis and body mass index (BMI) are known to influence reproductive outcomes, but their combined impact on in vitro fertilization (IVF) success remains uncertain.</p><h3>Objective</h3><p>To evaluate the relationship between BMI and the risk of endometriosis, and to assess how endometriosis—with or without prior surgical treatment—affects IVF outcomes, including oocyte yield, maturity, clinical pregnancy rates, and live birth rates.</p><h3>Methods</h3><p>This meta-analysis included 19 studies identified through comprehensive searches of databases including PUBMED, MEDLINE, and EMBASE. Primary outcomes assessed were the association between BMI and endometriosis risk, number of oocytes retrieved, and number of mature oocytes (MII). Secondary outcomes included clinical pregnancy rates, live birth rates, and the influence of prior surgery on IVF outcomes in women with endometriosis.</p><h3>Results</h3><p>BMI significantly influenced the risk of endometriosis, with obese women showing an increased risk (OR: 2.28) and normal-weight women showing a protective effect (OR: 0.45). Women with endometriosis had fewer total oocytes (mean difference [MD]: −2.06) and mature oocytes (MD: −2.07) compared to women without endometriosis undergoing IVF. While clinical pregnancy rates were not significantly different between groups (OR: 1.03), live birth rates were significantly lower in the endometriosis group (OR: 0.87). In a subgroup analysis of women who underwent prior surgical treatment for endometriosis, no improvement was observed in clinical pregnancy rates (OR: 0.79), and live birth rates were further reduced (OR: 0.67).</p><h3>Conclusions</h3><p>Higher BMI is associated with an increased risk of endometriosis, which negatively affects IVF outcomes by reducing oocyte yield and live birth rates. Prior surgical treatment does not appear to enhance IVF success and may further compromise live birth outcomes.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"312 4","pages":"1085 - 1093"},"PeriodicalIF":2.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-025-08137-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The implementation of frailty assessment in gynecologic oncology: an international multicenter JAGO-NOGGO survey 虚弱评估在妇科肿瘤中的实施:一项国际多中心JAGO-NOGGO调查。
IF 2.5 3区 医学
Archives of Gynecology and Obstetrics Pub Date : 2025-07-31 DOI: 10.1007/s00404-025-08129-w
C. Flethe, C. Krause, A. von Beckerath, S. Alavi-Demirci, G. Kolb, M. Beck, K. Pietzner, J. Sehouli
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