Archives of Gynecology and Obstetrics最新文献

{"title":"Attachment, emotion regulation and quality of life in women with a diagnosis of endometriosis: a cross-sectional study","authors":"Cristina Sechi,&nbsp;Monica Ahmad,&nbsp;Stefano Guerriero,&nbsp;Silvia Ajossa,&nbsp;Laura Vismara","doi":"10.1007/s00404-026-08512-1","DOIUrl":"10.1007/s00404-026-08512-1","url":null,"abstract":"<div><h3>Purpose</h3><p>Endometriosis, a prevalent gynecological condition, significantly impacts physical, psychological, and social well-being. This study explores the relationship between attachment styles, emotion regulation difficulties, and quality of life in women with endometriosis. Drawing on attachment theory, the study hypothesized that secure attachment would correlate with fewer emotion regulation difficulties and higher quality of life, while insecure attachment styles would correlate with greater difficulties and lower quality of life.</p><h3>Methods</h3><p>The study included 354 Italian women diagnosed with endometriosis. Participants completed the Relationship Questionnaire to assess attachment styles, the Difficulties in Emotion Regulation Scale—Short Form to evaluate emotion regulation, and the WHOQOL–BREF to measure quality of life. Data analysis employed structural equation modeling to examine the direct and indirect effects of attachment styles on quality of life, mediated by emotion regulation difficulties.</p><h3>Results</h3><p>Results confirmed the hypotheses: secure attachment was associated with better emotion regulation and higher quality of life, whereas preoccupied and fearful attachment styles were linked to greater emotion regulation difficulties and lower quality of life. The dismissing attachment style did not show significant associations.</p><h3>Conclusions</h3><p>The findings underscore the importance of addressing emotion regulation in therapeutic interventions for women with endometriosis.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"313 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13633136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148410099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personal experience with abortion influences how we practice as obstetrician–gynecologists","authors":"Katherine J. Kramer,&nbsp;Sarah Ottum,&nbsp;Danna Ghafir,&nbsp;Capricia Bell,&nbsp;Mitchell Reider,&nbsp;Caroline McClure,&nbsp;Maurice-Andre Recanati","doi":"10.1007/s00404-026-08369-4","DOIUrl":"10.1007/s00404-026-08369-4","url":null,"abstract":"<div><h3>Purpose</h3><p>To evaluate whether a personal history of having an abortion, or knowing someone close who did, has an impact on how a physician practices.</p><h3>Methods</h3><p>A web-based survey was sent to Ob/Gyn residents asking about personal abortion experience, demographics, religious background, political views, residency program metrics, and intent to provide abortion. Pearson Chi-square and Mann–Whitney U tests were performed to assess whether or not personal history of abortion (PHA) was significantly associated with personal characteristics or training patterns.</p><h3>Results</h3><p>Ob/Gyn residents with a personal history of abortion were older in age (<i>p</i> = 0.002), sought out additional training in family planning (<i>p</i> = 0.009), considered it extremely important that their program offers family planning training (<i>p</i> &lt; 0.001), and were much more likely to intend to become an abortion provider themselves post-residency (<i>p</i> &lt; 0.001).</p><h3>Conclusion</h3><p>Personal experience is associated with training and practice patterns among Ob/Gyn residents, a finding that has implications for an Ob/Gyn workforce under pressure from increasing legislative restrictions to abortion care. Ob/Gyn residents should be supported in their training goals to combat moral injury associated with the inability to provide evidence-based care.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"313 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13633139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148410110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prospective surgical evaluation of the coexistence of endometriosis and interstitial cystitis/bladder pain syndrome","authors":"Giovanni Favero,&nbsp;Felix Zeppernick,&nbsp;Magdalena Zeppernick,&nbsp;Tatiana Pfiffer,&nbsp;Thilo Schwandner,&nbsp;Ivo Meinhold-Heerlein","doi":"10.1007/s00404-026-08507-y","DOIUrl":"10.1007/s00404-026-08507-y","url":null,"abstract":"<div><h3>Background</h3><p>Endometriosis and interstitial cystitis/bladder pain syndrome (IC/BPS) frequently coexist; however, diagnostic delays and non-standardized criteria limit accurate identification of these conditions.</p><h3>Objective</h3><p>To assess the feasibility, safety, and clinical characterization of coexisting endometriosis and IC/BPS using a standardized surgical evaluation approach.</p><h3>Methods</h3><p>In this prospective single-center study, approximately 100 women with presumed endometriosis and bladder symptoms undergoing laparoscopy for staging and/or treatment will simultaneously undergo diagnostic cystoscopy for IC/BPS. Optical confirmation and phenotype characterization of IC/BPS will be assessed. In cases with cystoscopic signs of IC/BPS, a standardized therapeutic protocol will be initiated to address bladder-centric symptoms alongside endometriosis treatment.</p><h3>Results</h3><p>The study will evaluate whether systematic surgical assessment enables reliable detection of coexisting endometriosis and IC/BPS and facilitates the identification of bladder-centric and non–bladder-centric IC/BPS phenotypes. Early recognition of IC/BPS in women with endometriosis may reduce unnecessary interventions and inform individualized management strategies.</p><h3>Discussion</h3><p>The combination of standardized laparoscopy and cystoscopy may improve diagnostic precision in patients with suspected coexisting endometriosis and IC/BPS. The study is expected to provide insights that support phenotype-driven, multidisciplinary care and inform future research and the development of integrated diagnostic algorithms.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"313 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-026-08507-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148403447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive markers of endometriosis: a future perspective","authors":"Alexandre Vallée,&nbsp;Jean-Marc Ayoubi","doi":"10.1007/s00404-026-08499-9","DOIUrl":"10.1007/s00404-026-08499-9","url":null,"abstract":"<div><p>Endometriosis is a chronic gynecological disorder affecting up to 10% of women of reproductive age and is characterized by the presence of endometrial-like tissue outside the uterus. The condition is associated with chronic pelvic pain, dysmenorrhea, dyspareunia, and infertility, and remains difficult to diagnose at early stages. Recent evidence suggests that endometriosis shares genetic and molecular pathways with other chronic pain and inflammatory disorders. Identifying reliable biomarkers is therefore essential to improve risk stratification and support earlier evaluation. Multiple domains have emerged as candidate markers for risk stratification, including genetic and epigenetic alterations, dysmenorrhea, migraine, autoimmune and endocrine disorders, and stress and early-life adversity. These factors have been associated with disease initiation, lesion development, and symptom severity. Understanding their interactions could support multimodal risk stratification approaches and guide preventive strategies. This narrative review highlights the multifactorial nature of endometriosis and synthesizes current evidence on emerging predictive markers. Although progress has been made, large prospective studies are still needed to validate these markers and facilitate the development of targeted interventions.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"313 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13616853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148389831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phototoxicity of brightfield live-cell imaging on murine ovarian follicles","authors":"Marie Stadter,&nbsp;Ralf Dittrich,&nbsp;Lothar Häberle,&nbsp;Laura Lotz,&nbsp;Stefanie Brey,&nbsp;Nathalie Bleisinger,&nbsp;Benjamin Schmid,&nbsp;Matthias W. Beckmann,&nbsp;Anna K. Dietl","doi":"10.1007/s00404-026-08515-y","DOIUrl":"10.1007/s00404-026-08515-y","url":null,"abstract":"<div><h3>Purpose</h3><p>Within the female reproductive tract, fertilization and embryo development occur in the complete absence of light. Light exposure during the in vitro manipulation of ovarian follicles negatively affects follicle viability. Laboratory conditions involve exposure to varying wavelengths, intensities, and light sources.</p><h3>Methods</h3><p>In our study, we observed the effect of recurring light exposure on murine ovarian follicle viability subsequently assessed by evaluating increase in diameter, changes in morphology, and results from the LIVE/DEAD assay. A time-lapse approach allowed for effective observation of follicle interactions and viability, with no relevant movement or loss of focus throughout the imaging period.</p><h3>Results</h3><p>However, follicles exposed to light showed a significant increase in granulosa cell death, as indicated by the LIVE/DEAD assay. No significant difference was observed in regard to morphology.</p><h3>Conclusion</h3><p>Brightfield time-lapse provides a valuable tool for identifying early predictive signs and key milestones in follicle development, which may enhance in vitro follicle culture techniques and improve patient treatment outcomes, but simultaneously carries a risk of phototoxicity that must be considered when applying this method.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"313 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-026-08515-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148374309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First-trimester lipoprotein(a) and longitudinal renal biomarker trajectories preceding preeclampsia: a pilot cohort study","authors":"María Elena Lozoya-Angulo,&nbsp;Francisco Gerardo Cañizares-Hernández,&nbsp;Sara Requena-López,&nbsp;José Antonio Noguera-Velasco,&nbsp;Javier Sánchez-Romero,&nbsp;Catalina de Paco-Matallana","doi":"10.1007/s00404-026-08508-x","DOIUrl":"10.1007/s00404-026-08508-x","url":null,"abstract":"<div><h3>Purpose</h3><p>To evaluate whether early vascular susceptibility, reflected by first-trimester lipoprotein(a), together with longitudinal renal biomarker trajectories across pregnancy, is associated with the subsequent development of preeclampsia.</p><h3>Methods</h3><p>Retrospective analysis of prospectively collected data from a high-risk pregnancy cohort. Maternal serum inflammatory (interleukin-6, C-reactive protein), lipid (lipoprotein(a), triglycerides, total cholesterol), and renal (uric acid, cystatin C) biomarkers were measured at 11–13, 19–22, and 32 weeks of gestation. Longitudinal changes were assessed using population-averaged models including trimester, preeclampsia status, and their interaction, adjusted for maternal age and body mass index. First-trimester lipoprotein(a) was evaluated using adjusted logistic regression.</p><h3>Results</h3><p>Among 119 women, 20 developed preeclampsia. First-trimester lipoprotein(a) concentrations were higher in women who later developed preeclampsia and were independently associated with increased risk (OR 2.38; <i>p</i> &lt; 0.001). Longitudinal analyses showed significant trimester-by-preeclampsia interactions for uric acid and cystatin C (both <i>p</i> = 0.03), indicating progressive divergence across pregnancy. Inflammatory biomarkers showed early between-group differences without significant longitudinal divergence.</p><h3>Conclusions</h3><p>Our findings suggest that preeclampsia may be associated with both early maternal vascular susceptibility and progressive alterations in renal biomarkers during pregnancy. Elevated first-trimester lipoprotein(a) may reflect an underlying vascular phenotype, while divergent renal biomarker trajectories highlight the dynamic evolution of the disease before clinical onset, although these findings require validation in larger prospective studies.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"313 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13593632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148366711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Intraoperative hemodynamics and anesthetic implications in superobese parturients undergoing cesarean delivery: a retrospective cohort analysis","authors":"Teshi Kaushik,&nbsp;Andrew Hackney,&nbsp;Ayesha Bryant,&nbsp;Elizabeth Baker,&nbsp;Sijules Abongwa,&nbsp;Brant M. Wagener,&nbsp;Michael Arnold Frölich","doi":"10.1007/s00404-026-08502-3","DOIUrl":"10.1007/s00404-026-08502-3","url":null,"abstract":"","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"313 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-026-08502-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148366747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-year outcome after laser treatment of vulvar lichen sclerosus: a prospective observational trial","authors":"Marianne Gamper,&nbsp;Irena Zivanovic,&nbsp;Helena Bischofberger,&nbsp;Volker Viereck","doi":"10.1007/s00404-026-08510-3","DOIUrl":"10.1007/s00404-026-08510-3","url":null,"abstract":"<div><h3>Purpose</h3><p>To assess the 12-month efficacy of a novel non-ablative dual Nd:YAG/Er:YAG laser therapy for vulvar lichen sclerosus (LS) and to evaluate the impact of crossover laser treatment following initial topical corticosteroid therapy.</p><h3>Methods</h3><p>This study presents the 1-year data of a prospective observational trial. Between baseline and 6 months, women with vulvar LS were randomized to receive either dual Nd:YAG/Er:YAG laser therapy or topical clobetasol propionate. Between 6 and 12 months, optional steroid or laser therapies were offered.</p><h3>Results</h3><p>In the laser group, 34 of 44 patients (77%) required no additional treatment between 6 and 12 months, indicating sustained treatment effects. The total LS score improved significantly during this period (mean change -0.35 ± 0.60; 95% CI -0.56 to -0.14; <i>p</i> = 0.004), while other parameters showed non-significant improvements. In the corticosteroid group, 20 of 22 patients (91%) opted for a crossover to laser therapy. Following three laser sessions, the total LS score improved markedly (mean change -1.50 ± 0.83; 95% CI -1.89 to -1.11; <i>p</i> &lt; 0.001), primarily driven by a reduction in atrophy (<i>p</i> &lt; 0.001). Patient-reported improvement (PGI-I) increased from 45 to 77% (<i>p</i> = 0.008). At the 12-month follow-up, outcomes were comparable between the two study groups.</p><h3>Conclusion</h3><p>Non-ablative dual Nd:YAG/Er:YAG laser therapy resulted in significant and sustained clinical improvement in vulvar LS over 12 months. Crossover to laser therapy after initial corticosteroid treatment further enhanced both objective and subjective outcomes.</p><h3>Clinical trial identification number</h3><p>NCT03926299; date of registration: 24 April 2019.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"313 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-026-08510-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148359153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic and treatment delay in women with cancer in pregnancy: a case-based study","authors":"Lillian Sun Liang,&nbsp;Iben Katinka Greiber,&nbsp;Mona Aarenstrup Karlsen,&nbsp;Berit Woetmann Pedersen,&nbsp;Birgitte Bruun Nielsen,&nbsp;Malene Kronborg Have,&nbsp;Rikke Bek Helmig,&nbsp;Maria Cathrine Schmidt,&nbsp;Jeanett Strandbygaard,&nbsp;Lone Storgaard","doi":"10.1007/s00404-026-08500-5","DOIUrl":"10.1007/s00404-026-08500-5","url":null,"abstract":"<div><h3>Purpose</h3><p>More advanced stages at diagnosis and lower survival rates are seen in women diagnosed with cancer during pregnancy compared to non-pregnant women with similar cancers. This study aims to investigate diagnostic and treatment delays, cancer stage, and survival in Danish pregnant cancer patients.</p><h3>Methods</h3><p>Patients from the Danish cancer in pregnancy database were included. Cancer diagnosis, treatment, and obstetrical data were collected from the database. Time to treatment was compared to national cancer patient pathways. Cancer stages at diagnosis were compared to epidemiological studies identified through a systematic literature search. Survival was compared to data from NORDCAN, a Nordic cancer statistics database.</p><h3>Results</h3><p>The study included 74 patients diagnosed with cancer in pregnancy. The median total delay was 43.5 days (IQR 27.75–94.75) with a patient delay of three days (IQR 0–31), a diagnostic delay of 15 days (IQR 8–35), and a treatment delay of 9.5 days (IQR 0–19). Time from cancer suspicion to start of treatment fell within recommended national cancer patient pathway intervals in 80.0% of cases. Breast cancer and melanoma in pregnancy tended to have more advanced stages at diagnosis compared to non-pregnant patients. The 1- and 5-year mortality rates were 5.4% and 17.6%, respectively.</p><h3>Conclusion</h3><p>Our findings suggest that pregnant cancer patients presented with advanced stages at diagnosis and lower survival rates compared to non-pregnant patients with similar cancers. Our results indicate that the main contributor to the delay in cancer in pregnancy in Denmark is delayed suspicion of cancer.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"313 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00404-026-08500-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148359174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ophthalmic artery Doppler: reference values in low-risk pregnant women","authors":"Ladina Campana-Rüegg,&nbsp;Martina Hofmann,&nbsp;Julia Wawrla-Zepf,&nbsp;Ruth von Mering,&nbsp;Markus Gonser,&nbsp;Nicole Ochsenbein-Kölble,&nbsp;Ladina Vonzun","doi":"10.1007/s00404-026-08489-x","DOIUrl":"10.1007/s00404-026-08489-x","url":null,"abstract":"<div><h3>Introduction</h3><p>Ophthalmic artery (OA) Doppler has been described as an independent parameter in predicting preeclampsia (PE). Considering that vasoconstriction occurs in the pathogenesis of PE and causes increased pulse wave reflection, it is not surprising that OA waveform changes appear in PE. It was found that of these waveform changes, the 2nd systolic peak (P2) and the peak ratio [PR = P2/P1 (P1 = 1st systolic peak)] showed the best performance in prediction and complementary diagnosis of PE. The aim of this study was to determine reference values for OA-Doppler indices in the 1st, 2nd, and 3rd trimesters and at term in low-risk pregnant women of a mixed European population.</p><h3>Materials/methods</h3><p>This is a prospective single-center cohort study conducted from 2020 to 2024. Only healthy pregnant women who gave informed consent were included. Women at high risk for PE or who developed PE were excluded. OA Doppler was performed according to a strict protocol at 4 distinct gestational-week (GW) intervals: 11–14 GW, 20–24 GW, 30–34 GW, and at term. The following systolic waveform parameters were focused on: P1, P2, and PR. Reference values were generated for these waveform parameters for these study intervals in the 1st, 2nd, and 3rd trimesters and at term.</p><h3>Results</h3><p>A total of 255 women were included in this study. Of these, 62% were Caucasian, 7% Asian, 8% Afro-Caribbean, and 33% mixed or of unknown ethnicity. In this population, the PR averaged over the study intervals was 0.56, with no significant differences between the 4 study intervals or between the right and left eyes.</p><h3>Conclusion</h3><p>This study presents systolic OA-Doppler reference values in low-risk pregnant women of an ethnically diverse European tertiary-care obstetric population. OA-Doppler reference values are stable throughout the four selected time points in pregnancy. These findings may pave the way for further investigations on OA-Doppler values as a predictive and diagnostic tool for PE.</p></div>","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":"313 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148359140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}