Archives of Medical Research最新文献

{"title":"Sex Specific Threshold Effects of Prenatal Stress on Striatal Microglia and Relevant Behaviors in Mice","authors":"Sara V. Maurer ,&nbsp;Maya M. Evans ,&nbsp;Mia Dukle ,&nbsp;Sreelekha Kundu ,&nbsp;Jessica L. Dennis ,&nbsp;Rhett M. Ellerbroek ,&nbsp;Samantha L. Anema ,&nbsp;Venezia C. Roshko ,&nbsp;Hanna E. Stevens","doi":"10.1016/j.arcmed.2025.103364","DOIUrl":"10.1016/j.arcmed.2025.103364","url":null,"abstract":"<div><h3>Background</h3><div>Prenatal stress, a neurodevelopmental disorder (NDD) risk factor, induces neurobehavioral alterations, including offspring neuroimmune cells. Variable offspring outcomes may arise from the extent to which prenatal stress crosses “thresholds” for specific effects. Therefore, we sought to determine offspring outcomes using models with different extents of prenatal stress. We focused on striatal outcomes, because of their relevance for NDDs.</div></div><div><h3>Methods</h3><div>Pregnant CD1 mice were assigned to four groups (each: n = 6): no stress (“NoS”) or stressors administered three times daily: i.p. saline injections (low prenatal stress, LoS), interleukin-6 injections as a component of prenatal stress (immune prenatal stress; ImS), or restraint stress + saline injections (high prenatal stress, HiS), embryonic days 12–18. Behavioral (open field, rotarod, amphetamine-induced stereotypy, water T-maze) and brain and placental immunohistochemical (Iba1, Ki67) assessments of offspring were performed.</div></div><div><h3>Results</h3><div>In adult offspring, HiS altered behaviors across males and females, while ImS induced fewer behavioral changes, and LoS did not affect behavior. Adult striatal microglia morphologies were mostly unchanged across groups, with only HiS altering striatal density of minimally-ramified cells. However, embryonic striatal microglia were affected by all stressors in distinct ways. The HiS model, and to a lesser extent LoS, also influenced immune components of the maternal-fetal interface: placental macrophages.</div></div><div><h3>Conclusions</h3><div>High and immune stress affected adult striatal-dependent behavior, exceeding the threshold necessary for persistent impacts mostly in males, but all stress models affected embryonic microglia, suggesting a lower threshold for early neuroimmune impacts. Distinct severities and aspects of prenatal stress may therefore underlie different NDD-relevant outcomes.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"57 1","pages":"Article 103364"},"PeriodicalIF":3.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145797158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment of High-Altitude Reference Values for the Pan-Immune-Inflammation Value in Healthy Adults Living in Mexico City","authors":"Luis M Amezcua-Guerra ,&nbsp;Malinalli Brianza-Padilla ,&nbsp;Mireya Martínez-García ,&nbsp;Guadalupe Gutiérrez-Esparza","doi":"10.1016/j.arcmed.2025.103281","DOIUrl":"10.1016/j.arcmed.2025.103281","url":null,"abstract":"<div><h3>Background</h3><div>The Pan-Immune-Inflammation Value (PIV) is a novel composite biomarker that combines neutrophil, monocyte, platelet, and lymphocyte counts. It is useful for prognostic stratification across various clinical conditions. However, reference values for PIV have predominantly been established in populations living below 1000 m, which limits its applicability in high-altitude regions.</div></div><div><h3>Aim</h3><div>To establish reference values for PIV and its hematological components in healthy adults living in Mexico City.</div></div><div><h3>Methods</h3><div>Data from the Tlalpan 2020 cohort, a prospective study of healthy adults aged 20–50 from Mexico City, were analyzed. Reference values were determined following the Clinical and Laboratory Standards Institute guidelines, with stratification by sex.</div></div><div><h3>Results</h3><div>A total of 2290 participants (63% women) with a mean age of 37.0 ± 9.1 years were included. The mean PIV was 249.6 ± 416.9, which decreased to 221.9 ± 332.2 after excluding outliers. Significant sex differences were observed, with women exhibiting higher PIV values. The reference ranges for the total cohort were 65.8–491.6, with sex-specific ranges of 66.7–519.1 for women and 62.8–441.3 for men. Women also had higher reference values for neutrophils and platelets, while monocytes and lymphocytes were similar between sexes.</div></div><div><h3>Conclusions</h3><div>This study provides high-altitude-specific reference values for PIV and its components in Mexico City’s population, which are notably lower than those in low-altitude regions. The observed sex differences highlight the importance of considering sex as a biological variable when interpreting immunoinflammatory biomarkers.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"57 1","pages":"Article 103281"},"PeriodicalIF":3.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144866389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"This Expression of Concern relates to: Kamalidehghan B, Houshmand M, Patimah I, Shafa Shariat Panahi M, Hosseini Akbari MH. ΔmtDNA4977 Is More Common in Non-tumoral Cells from Gastric Cancer Sample. Arch Med Res. 2006;37(6):730–735. https://doi.org/10.1016/j.arcmed.2006.02.005","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"57 6","pages":"Article 103493"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148499526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethical considerations in the use of add-ons in assisted reproductive technologies","authors":"Rocío Núñez Calonge ,&nbsp;Rafael Trinchant ,&nbsp;Josep Santaló ,&nbsp;Fernando Abellán ,&nbsp;Lydia Feito ,&nbsp;Alfonso De La Fuente ,&nbsp;Javier Marqueta ,&nbsp;Montserrat Roca ,&nbsp;Marina Martinez ,&nbsp;Elisa Salo ,&nbsp;Ignacio Arnott ,&nbsp;Víctor Saul Vital Reyes","doi":"10.1016/j.arcmed.2025.103287","DOIUrl":"10.1016/j.arcmed.2025.103287","url":null,"abstract":"","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"57 1","pages":"Article 103287"},"PeriodicalIF":3.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144902338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monocarboxylate Transporter 4 Inhibition Reduces Synovial Hyperproliferation and Metabolic Reprogramming Under Hypoxia in Rheumatoid Arthritis","authors":"Meican Ma,&nbsp;Ting Liu,&nbsp;Haifeng Chen,&nbsp;Zhao Wang,&nbsp;Jie Zhou,&nbsp;Yu Zhou,&nbsp;Fenghong Yuan","doi":"10.1016/j.arcmed.2025.103283","DOIUrl":"10.1016/j.arcmed.2025.103283","url":null,"abstract":"<div><h3>Objectives</h3><div>In hypoxic conditions, the acidic environment characteristic of rheumatoid arthritis (RA) induces metabolic changes in fibroblast-like synoviocytes (FLS), markedly promoting the synovial proliferation. Monocarboxylate transporter 4 (MCT4) plays a crucial role in cellular pH regulation and synovial fibroblast activation by regulating lactate export. This study investigates the impact of MCT4 inhibition on RA and elucidates its underlying mechanisms.</div></div><div><h3>Method</h3><div>RA-FLS cells were treated with siMCT4 and VB124 (a selective MCT4 inhibitor), significantly affecting glucose and glutamine uptake and altering lactate efflux. Metabolite analysis using liquid chromatography-mass spectrometry (LC-MS) revealed the mechanisms of carbon metabolism reprogramming. ChIP-qPCR analysis demonstrated changes in hypoxia-inducible factor-1α (HIF1-α) binding to the MCT4 promoter. The therapeutic effects of siMCT4 and VB124 were validated in a collagen-induced arthritis (CIA) model, and their efficacy was assessed through arthritis scores and histological examination.</div></div><div><h3>Results</h3><div>In patients with RA, MCT4 levels are significantly elevated. Inhibition of MCT4 effectively reduces synovial hyperproliferation and impacts metabolic reprogramming. Specifically, blocking MCT4 in RA-FLS reduces glucose consumption and lactate production while remodeling the metabolic landscape by increasing fumarate, citrate, and malate levels, and decreasing glucose-6-phosphate and aspartate levels. This metabolic shift is accompanied by improvements in mitochondrial structure and function, reduced mitochondrial swelling, and decreased oxidative stress, underscoring the relationship between MCT4 inhibition and cellular energetics. Furthermore, our investigations reveal that HIF1-α directly regulates MCT4 activation, providing a molecular mechanism by which hypoxia promotes MCT4-mediated metabolic reprogramming.</div></div><div><h3>Conclusion</h3><div>These findings highlight MCT4 as a central regulator of RA proliferation and a promising therapeutic target.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"57 1","pages":"Article 103283"},"PeriodicalIF":3.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144866484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling Longitudinal Weight Dynamics in Type 2 Diabetes: Insights From a Comprehensive Care Program","authors":"Ana C. García-Ulloa ,&nbsp;Liliana Pérez-Peralta ,&nbsp;Luz E. Urbina-Arronte ,&nbsp;José L. Cárdenas-Fragoso ,&nbsp;Maria V. Landa-Anell ,&nbsp;Marco A. Melgarejo-Hernández ,&nbsp;Valeria Miranda Gil ,&nbsp;Sergio Ponce-de-León ,&nbsp;Sergio Hernández-Jiménez ,&nbsp;Group of Study CAIPaDi","doi":"10.1016/j.arcmed.2025.103271","DOIUrl":"10.1016/j.arcmed.2025.103271","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Overweight and obesity are prevalent conditions that contribute to significant health problems, including type two diabetes (T2D). Moderate weight loss improves metabolic control and cardiovascular risk. We aimed to identify the demographic and clinical characteristics of patients with T2D who experienced weight changes after a multidisciplinary intervention.</div></div><div><h3>Methods</h3><div>We analyzed 622 patients with complete 3-year follow-up information. Inclusion criteria were less than 5-years since diabetes diagnosis and an absence of disabling chronic complications. Descriptive statistics, ANOVA or Kruskal-Wallis tests were used for group comparisons, and logistic regression to identify predictors of weight change.</div></div><div><h3>Results</h3><div>Participants were 56.2 % women, with an average age of 55.8 ± 10.5 years. 53 % were overweight and 47 % were obese at baseline. At 3-years, 35.5 % lost weight, 33.9 % maintained weight, and 30.5 % gained weight; 16.6 % achieved a normal weight. Patients who gained weight were younger than those who lost or maintained it (60 vs. 61 years, <em>p</em> = 0.04). Higher baseline HbA1c (OR 1.14, 95 % CI 1.03–1.26, <em>p</em> = 0.008) and lower quality of life at three months (OR 1.48, 95 % CI 0.95–2.28, <em>p</em> = 0.07) were associated with weight gain. Higher baseline BMI (OR 0.90, 95 % CI 0.85–0.95, <em>p</em> &lt; 0.001), longer diabetes duration (OR 0.81, 95 % CI 0.70–0.94, <em>p</em> = 0.005), and iSGLT2 treatment were linked to weight loss.</div></div><div><h3>Conclusion</h3><div>Only 16 % of patients achieved normal weight after 3-years: 35.5 % lost weight, 33.9 % maintained their weight, and 30.5 % gained weight. Identifying predictors of weight change may guide targeted interventions in diabetes care.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"57 1","pages":"Article 103271"},"PeriodicalIF":3.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144866489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uterus Transplantation: State of the Art in and Arrent Status in Mexico","authors":"Luis Eduardo Magdaleno-Marquez ,&nbsp;Sonny John Stetson ,&nbsp;Aldo Loza Mapomé ,&nbsp;Julio César Del Hierro Yepo ,&nbsp;Juan Carlos Cantón Romero ,&nbsp;Edwin Ramirez ,&nbsp;Federico Mendoza Sánchez ,&nbsp;Diego Federico Mendoza Medina ,&nbsp;Roberto Enrique Díaz González ,&nbsp;Martha Isolina García Amador ,&nbsp;Luis Arturo Ruvalcaba-Castellon","doi":"10.1016/j.arcmed.2025.103280","DOIUrl":"10.1016/j.arcmed.2025.103280","url":null,"abstract":"<div><div>This study examines uterine transplantation (UTx) in 2024. It focuses on various aspects, such as animal models, clinical outcomes, surgical procedures, patient perspectives, and ethical and legal considerations. The study particularly considers the context of Mexico. We also explore collaborative initiatives and the public health implications of this innovative reproductive advancement technology.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"57 1","pages":"Article 103280"},"PeriodicalIF":3.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145010565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reviewers list","authors":"","doi":"10.1016/S0188-4409(25)00189-4","DOIUrl":"10.1016/S0188-4409(25)00189-4","url":null,"abstract":"","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"57 1","pages":"Article 103371"},"PeriodicalIF":3.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146074090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Adipose Tissue Depots in Immediate versus Delayed Breast Reconstruction","authors":"Carlos Pinho ,&nbsp;Beatriz Soares ,&nbsp;Beatriz Costa ,&nbsp;Diogo Teixeira ,&nbsp;Maria J. Salazar ,&nbsp;Fani L. Neto ,&nbsp;Henrique Almeida ,&nbsp;António Costa-Ferreira ,&nbsp;Adriana R. Rodrigues ,&nbsp;Alexandra M. Gouveia","doi":"10.1016/j.arcmed.2025.103360","DOIUrl":"10.1016/j.arcmed.2025.103360","url":null,"abstract":"<div><h3>Background</h3><div>Mastectomy followed by breast reconstruction is the standard treatment for breast cancer. Choosing autologous tissue requires an in-depth understanding of the molecular and structural characteristics of the different adipose tissue depots.</div></div><div><h3>Method</h3><div>White adipose tissue (WAT) from five different locations (above and below the abdominal Scarpa’s fascia, thighs, breast skin envelope, and omentum) was collected from 24 patients undergoing breast reconstruction and grouped based on immediate (IBR) or delayed (DBR) reconstruction. The adipocyte area was analyzed in histologically processed WAT sections. Transcription and protein expression profiles, related to inflammation, fibrosis, browning, and adipose-derived stem cells (ADSCs) content were determined by RT-qPCR and Western blotting.</div></div><div><h3>Results</h3><div>Compared to IBR, omental WAT from DBR patients exhibits larger adipocytes, and higher expression of <em>TIMP1, FN1, CD206</em>, and <em>CD45</em>, as well as lower levels of <em>CIDEA</em>. Breast fat also differs between the two groups, with lower levels of <em>IL6</em> and <em>CIDEA,</em> and overexpression of <em>FN1</em> in the DBR group. Within the IBR group, breast fat shows higher levels of <em>IL6, TIMP1</em> and <em>CIDEA</em>, but lower expression of <em>FN1</em> and <em>COL3A1</em> than subcutaneous WAT.</div></div><div><h3>Conclusion</h3><div>Omental fat in the IBR cohort has properties similar to those of subcutaneous WAT, indicating that the omentum is a promising candidate for rapid breast restoration. In the DBR group, the omentum molecular signature suggests a change towards a pro-fibrotic phenotype and a reduced remodeling capacity, suggesting that it should not be the primary choice for breast reconstruction. This study emphasizes the importance of careful WAT selection to minimize adverse outcomes, including cancer recurrence, and underscores the diverse physiology of fat depots.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"57 1","pages":"Article 103360"},"PeriodicalIF":3.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145829242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Primer on Monkeypox Infection: An Emerging Threat to Global Public Health","authors":"Rasanpreet Kaur ,&nbsp;Saurabh Gupta ,&nbsp;Shreya Pathak ,&nbsp;Manish Sharma ,&nbsp;Deepak Parashar ,&nbsp;Bhuvnesh Prasad Sharma ,&nbsp;Vivek Kashyap ,&nbsp;Jitendra Singh ,&nbsp;Chakresh Jain ,&nbsp;Prem Shankar","doi":"10.1016/j.arcmed.2025.103279","DOIUrl":"10.1016/j.arcmed.2025.103279","url":null,"abstract":"<div><div>Monkeypox (mpox) is caused by a poxvirus closely related to the smallpox virus. It spreads by intimate contact between humans and animals. Prior immunization against smallpox only provides partial protection against mpox. Recently, the WHO declared mpox as a global public health emergency. Mpox is characterized by a brief febrile illness with lymphadenopathy, followed by a rash that develops in phases of macules, papules, vesicles, and pustules, spreading centrifugally. Most patients recover within two to four weeks. Children, pregnant women, and immunocompromised individuals are more likely to experience complications. A precise laboratory diagnosis can be made by using a molecular method, such as polymerase chain reaction (PCR) to detect viral DNA in the tested sample. Most of the treatment is symptomatic, and supportive care is usually sufficient for moderate, self-limited cases of mpox. However, antiviral medications, such as tecovirimat, brincidofovir, and cidofovir, as well as vaccinia immune globulin intravenous (VIGIV), are available as therapeutic options. For high-risk groups, such as healthcare professionals and close contacts, vaccination with currently available smallpox vaccines is advised. This review emphasizes an overview of the history, etiology, epidemiology, structure, reservoirs, transmission, virus phylogeny, genome organization, clinical cases and symptoms, diagnosis, treatment, and prevention of mpox with recent updates. Therefore, a multifaceted approach is essential and includes improved surveillance, early diagnosis, isolation of index cases, immunization, and adoption of a “One Health” approach to prevent an mpox outbreak.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"57 1","pages":"Article 103279"},"PeriodicalIF":3.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144866483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}