Changing Landscape of Liver Cirrhosis Etiologies

IF 4.7 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Archives of Medical Research Pub Date : 2025-05-27 DOI:10.1016/j.arcmed.2025.103240

Nahum Méndez-Sánchez , Mariana M Ramírez-Mejía , Ming-Hua Zheng , Carlos Cortez-Hernández , Elianee M Tovar-Bojorquez , Raúl Contreras-Omaña , Juan D Monsiváis-Morales , Jacqueline Córdova-Gallardo , Mauricio Castillo-Barradas , Nubia Guzmán-Rodríguez , María S González-Huezo , Adrian Sandez-Araiza , Eira Cerda-Reyes , Stefanny Cornejo-Hernández , Beatriz Barranco-Fragoso , Ana D Cano-Contreras , José M Remes-Troche , Fatima Higuera-de-la-Tijera , José L Pérez-Hernández , Norberto Chávez-Tapia , Heriberto Rodríguez-Hernández

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引用次数: 0

Abstract

Background and Aims

Liver cirrhosis is a major public health problem worldwide. In Mexico, the increased prevalence of obesity and type 2 diabetes mellitus (T2DM) has contributed to an increase in the prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD). This study examines the current etiologies of cirrhosis in Mexico, highlighting regional and demographic differences.

Methods

We conducted a multicenter cross-sectional study of 2182 patients with cirrhosis diagnosed between 2018 and 2024 in 13 tertiary care hospitals in northern, central, and southern Mexico. Demographic data, etiology, and complications were analyzed.

Results

MASLD was the most frequent cause of cirrhosis (42.8 %), followed by alcohol-related liver disease (ALD, 23.8 %) and hepatitis C virus (HCV, 12.2 %). MASLD was more common in older patients and women, while ALD was more frequent in younger patients and men. HCC was observed in 8.9 % of patients, with a higher prevalence in the central region. The most common complications were portal hypertension (59.5 %) and ascites (30.4 %). Regional differences were observed, with a higher prevalence of MASLD in central and southern Mexico, while ALD was more prominent in the northern region.

Conclusion

This cross-sectional study underscores the changing etiologies of liver cirrhosis in Mexico, with MASLD emerging as the leading cause, particularly in older patients and women. Regional differences were evident, with ALD being more frequent in younger patients and in men, especially in the northern region.

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肝硬化病因的变化趋势

背景和目的肝硬化是世界范围内的一个主要公共卫生问题。在墨西哥，肥胖和2型糖尿病（T2DM）患病率的增加导致了代谢功能障碍相关脂肪变性肝病（MASLD）患病率的增加。本研究考察了目前墨西哥肝硬化的病因，强调了区域和人口差异。方法：我们对墨西哥北部、中部和南部13家三级医院2018年至2024年间诊断为肝硬化的2182例患者进行了一项多中心横断面研究。对人口统计资料、病因及并发症进行分析。结果smasld是肝硬化最常见的原因（42.8%），其次是酒精相关性肝病（ALD, 23.8%）和丙型肝炎病毒（HCV, 12.2%）。MASLD在老年患者和女性中更为常见，而ALD在年轻患者和男性中更为常见。在8.9%的患者中观察到HCC，中部地区的患病率较高。最常见的并发症是门静脉高压（59.5%）和腹水（30.4%）。观察到区域差异，墨西哥中部和南部的MASLD患病率较高，而ALD在北部地区更为突出。这项横断面研究强调了墨西哥肝硬化病因的变化，MASLD成为主要原因，特别是在老年患者和女性中。地区差异很明显，ALD在年轻患者和男性中更为常见，特别是在北部地区。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Medical Research 医学-医学：研究与实验

CiteScore

12.50

自引率

0.00%

发文量

审稿时长

28 days

期刊介绍： Archives of Medical Research serves as a platform for publishing original peer-reviewed medical research, aiming to bridge gaps created by medical specialization. The journal covers three main categories - biomedical, clinical, and epidemiological contributions, along with review articles and preliminary communications. With an international scope, it presents the study of diseases from diverse perspectives, offering the medical community original investigations ranging from molecular biology to clinical epidemiology in a single publication.