Archives of Medical Research最新文献

{"title":"Comorbidities and Sociodemographic Factors as Determinants of COVID-19 Outcome in Hospitalized Pregnant Women in Brazil","authors":"Francilene Maria Azevedo ,&nbsp;Ariane Ribeiro de Freitas Rocha ,&nbsp;Núbia de Souza de Morais ,&nbsp;Sarah Aparecida Vieira Ribeiro ,&nbsp;Silvia Eloiza Priore ,&nbsp;Jackson Martins Rodrigues ,&nbsp;Sylvia do Carmo Castro Franceschini","doi":"10.1016/j.arcmed.2025.103184","DOIUrl":"10.1016/j.arcmed.2025.103184","url":null,"abstract":"<div><h3>Introduction</h3><div>SARS-CoV-2 infection during pregnancy causes maternal health complications.</div></div><div><h3>Objective</h3><div>To investigate the relationship between comorbidities and sociodemographic factors with COVID-19 outcome (death/healing) among hospitalized pregnant women in Brazil.</div></div><div><h3>Methodology</h3><div>A longitudinal study, based on secondary data from the SIVEP Gripe. All hospitalizations of adult pregnant women with COVID-19 were assessed, with a total sample of 16,202 women. The dependent variable was the evolution of COVID-19 hospitalizations (death/healing), and the independent variables were age, ethnicity, gestational trimester, immunization, and comorbidities. R software version 4.3.2 was used to analyze the data. Descriptive statistics, the χ² test, and Poisson regression were used. Joinpoint regression analysis was used to assess trends in lethality during the pandemic.</div></div><div><h3>Results</h3><div>The median age of the pregnant women assessed was 30 years (P25- 25; P75- 35). Lethality was 7.62 % (<em>n</em> = 1,236), and death was associated with the group of women who did not receive any dose of vaccine in the second trimester of pregnancy, were aged ≥35 years, and had black/brown skin color. The risk of death was higher among unvaccinated women (RR: 4.29; CI: 2.97–6.50), those aged ≥35 years (RR: 1.37; CI: 1.13–1.67), and those with obesity (RR: 2.08; CI: 1.66–2.58). In the temporal analysis, the monthly percentage change (MPC) in lethality was significant in three periods.</div></div><div><h3>Conclusion</h3><div>Black ethnicity, obesity, and lack of vaccination were the main factors that increased the risk of death from COVID-19 among pregnant women.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 4","pages":"Article 103184"},"PeriodicalIF":4.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143480546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mexican Interdisciplinary Consensus on the Diagnosis and Preventive Measures for Respiratory Syncytial Virus Infections","authors":"Rosa Maria Wong-Chew ,&nbsp;Daniel E. Noyola ,&nbsp;Fortino Solórzano-Santos ,&nbsp;Sarbelio Moreno-Espinosa ,&nbsp;Maria Guadalupe Miranda-Novales ,&nbsp;Eric Ochoa Hein ,&nbsp;Arturo Galindo-Fraga ,&nbsp;Diana Vilar-Compte ,&nbsp;Gerardo Martinez-Aguilar ,&nbsp;Rodolfo Norberto Jiménez-Juárez ,&nbsp;Gilberto Tena- Alavez ,&nbsp;Dina Villanueva-García ,&nbsp;Martha Eugenia Valdivia-Proa ,&nbsp;Pedro Antonio Martinez-Arce ,&nbsp;Alejandro Ernesto Macías-Hernández ,&nbsp;Francisco Javier Espinosa-Rosales ,&nbsp;Daniel Ibarra-Rios ,&nbsp;Guillermo Ruiz Palacios y Santos ,&nbsp;Martha Josefina Avilés-Robles ,&nbsp;Emilia Josefina Patiño-Bahena ,&nbsp;Patricia Cornejo-Juarez","doi":"10.1016/j.arcmed.2025.103183","DOIUrl":"10.1016/j.arcmed.2025.103183","url":null,"abstract":"<div><h3>Background</h3><div>Respiratory syncytial virus (RSV) is a common cause of respiratory illness in children and adults in Latin America and Mexico. RSV circulates with seasonal peaks in fall and winter. Individuals at highest risk for severe infection are premature infants and those with comorbidities, as well as older adults with cardiopulmonary pathologies and/or varying degrees of immunocompromise.</div></div><div><h3>Objective</h3><div>To provide an updated landscape of the epidemiology, risk groups, diagnostic methods, and prevention of RSV infection in Mexico.</div></div><div><h3>Methods</h3><div>Convened by the Asociación Mexicana de Infectología y Microbiología Clínica, 28 interdisciplinary experts participated in a consensus meeting held in November 2023. Four groups, each with seven experts and a medical writer, were formed to discuss epidemiology and diagnosis, risk groups, vaccines, and monoclonal antibodies (mABs). Predefined questions, formulated by a team of four experts, were discussed within each group, and consensus was reached on the answers. These responses were then analyzed and organized into recommendations based on national and international evidence.</div></div><div><h3>Results</h3><div>Evidence-based recommendations for epidemiological surveillance, diagnosis, and prevention of RSV infection were proposed. Future perspectives regarding the usefulness of new vaccines and passive immunoprophylaxis were analyzed.</div></div><div><h3>Conclusions</h3><div>Timely identification of at-risk populations, diagnosis and treatment of RSV infection, and particularly the rational use of mABs and vaccines are key strategies to reduce the clinical and epidemiological burden of RSV infection.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 4","pages":"Article 103183"},"PeriodicalIF":4.7,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143445344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loneliness and cognitive function in older adults living in Latin America: A systematic review","authors":"David Camacho ,&nbsp;Pamela Tella-Vega ,&nbsp;Fernando A. Wagner ,&nbsp;Carolina Santamaría-Ulloa ,&nbsp;Amanda Lehning ,&nbsp;Joseph J. Gallo ,&nbsp;Carmen García-Peña","doi":"10.1016/j.arcmed.2025.103182","DOIUrl":"10.1016/j.arcmed.2025.103182","url":null,"abstract":"<div><div>English language systematic reviews with samples from high-income countries have found an inverse relationship between loneliness and cognitive function. Considering that cultural and contextual resources influence the experience of loneliness and cognitive health, we conducted a systematic review analyzing quantitative studies exploring the relationship between loneliness and cognitive function in older adults in Latin America. Following PRISMA guidelines, we used five databases (PubMed, PsycInfo, Scopus, LILACS, and SciELO). Inclusion criteria were: a) quantitative research examining the relationship between loneliness and cognitive health, b) descriptions of loneliness and measures of cognitive function, c) English or Spanish language peer-reviewed articles, and d) a sample of older adults in Latin America (≥60 years). We assessed bias using the Risk of Bias Instrument for Cross-Sectional Surveys of Attitudes and Practices. Seven of the 1,887 studies (all cross-sectional) met the inclusion criteria, comprising 26,440 participants from Brazil or Mexico. Most, but not all, found a significant inverse association between loneliness and cognitive function after controlling for salient health and psychosocial factors. Measures and conceptualizations of loneliness and cognitive function, as well as theoretical explanations linking these concepts, varied. Two studies had a high risk of bias. Current evidence suggests a possible cross-sectional association between loneliness and cognitive function in older adults in these countries. Further research is needed to examine the possible bidirectional relationship using representative samples and longitudinal designs; test pathways linking dimensions of loneliness (e.g., chronicity) to cognitive function (e.g., Alzheimer's disease continuum), and explore Latin American diversity (e.g., countries, indigenous peoples, sexual minorities).</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 4","pages":"Article 103182"},"PeriodicalIF":4.7,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143445431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Galectins: A New Frontier in Gastroesophageal Reflux Disease Research","authors":"Huda Saleem Hantoosh Hameed Al-khalidy ,&nbsp;Wafaa Hazim Salih ,&nbsp;Batool Mutar Mahdi","doi":"10.1016/j.arcmed.2025.103195","DOIUrl":"10.1016/j.arcmed.2025.103195","url":null,"abstract":"<div><h3>Background</h3><div>Gastroesophageal reflux disease (GERD) is a common chronic condition characterized by abnormal reflux and regurgitation of stomach contents into the esophagus. Its prevalence is increasing worldwide and poses a high economic burden.</div></div><div><h3>Aim</h3><div>To explore the potential correlation between galectin-1, galectin-3, galectin-8, galectin-9, and GERD, highlighting their potential role as biomarkers in disease diagnosis, and pathogenesis.</div></div><div><h3>Materials and Methods</h3><div>A prospective cross-sectional study was conducted on 40 patients with GERD disease and 40 healthy control subjects from January 2023–May 2024 at Al-Kindy Teaching Hospital-Gastroenterology Unit. Venous blood was collected from patients and controls. Serums of both groups were quantified for galectin-1, galectin-3, galectin-8, and galectin-9 using a human ELISA kit.</div></div><div><h3>Results</h3><div>Galectin-1 showed no statistically significant difference in the median levels between patients with GERD and controls (<em>p</em> = 0.567). A significant difference was found in the median levels of galectin-3, with higher levels in patients with GERD compared to controls (<em>p</em> = 0.0037). The most significant was galectin-3, AUC = 0.684 (95% CI: 0.570–0.784), <em>p</em> = 0.003, had a significant moderate discriminatory ability in differentiating between patients with GERD and healthy controls with cutoff value &lt;13.682, sensitivity = 74.4%, specificity = 55%, and accuracy = 61.7%.</div></div><div><h3>Conclusions</h3><div>This study suggests that serum galectin-3 is the best potential noninvasive diagnostic biomarker for the prediction and identification of GERD.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 4","pages":"Article 103195"},"PeriodicalIF":4.7,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143420159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predominance of FQR1 NAP1/RT027 Clostridioides difficile Among Mexican Children and Adult Patients, and its Resistance to Eleven Antibiotics","authors":"Emmanuel Aguilar-Zamora ,&nbsp;Cesar Rodríguez ,&nbsp;Javier Torres ,&nbsp;Nayeli Ortiz-Olvera ,&nbsp;Gerardo Aparicio-Ozores ,&nbsp;Lourdes Flores-Luna ,&nbsp;Carlos Quesada-Gómez ,&nbsp;Margarita Camorlinga-Ponce","doi":"10.1016/j.arcmed.2024.103171","DOIUrl":"10.1016/j.arcmed.2024.103171","url":null,"abstract":"<div><h3>Aims</h3><div><em>Clostridioides difficile</em> is a major cause of antibiotic-associated diarrhea. This study investigated the diversity, clonality, and antimicrobial resistance of <em>C. difficile</em> isolates from Mexican children and adults with diarrhea.</div></div><div><h3>Methods</h3><div>Between 2014 and 2016<em>,</em> we isolated 37 <em>C. difficile</em> strains in three hospitals in Mexico City. <em>C. difficile</em> strains were typed by PCR-ribotyping and pulsed-field gel electrophoresis (PFGE). Antimicrobial susceptibility to eleven antibiotics was determined. Whole-genome sequencing (WGS) was used to investigate the presence of antimicrobial resistance genes (ARG) and perform a pangenome analysis of 53 genomes from Mexico and 137 publicly available <em>C. difficile</em> genomes.</div></div><div><h3>Results</h3><div>Toxigenic strains comprised six isolates from children and 31 from adults. While NAP1/RT027 isolates were found in three children, they were predominant in adults (<em>n</em> = 31, 90.3 %) and showed the 1058 and 008 PFGE macrorestriction patterns. All isolates were susceptible to vancomycin and metronidazole but resistant to ciprofloxacin, and over 90 % of the isolates were resistant to linezolid and carried <em>cfr</em>(E). The pangenome of these isolates contained 4,852 genes, of which 3,455 (81.2 %) were categorized as core genes and 801 (18.8 %) as accessory genes. In addition, our isolates demonstrated a close relationship with strains from the United States, Canada, and France.</div></div><div><h3>Conclusions</h3><div>Our work provides, for the first time, genomic insights into <em>C. difficile</em> strains present in Mexico. In our hospital setting, the predominant strains were primarily NAP1/RT027 and exhibited resistance to linezolid, a pattern observed in both pediatric and adult populations. This unique combination of characteristics has not been previously reported in Latin America.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 4","pages":"Article 103171"},"PeriodicalIF":4.7,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143388450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracellular Vesicle-based Delivery of Paclitaxel to Lung Cancer Cells: Uptake, Anticancer Effects, Autophagy and Mitophagy Pathways","authors":"Shabnam Pirnezhad Talatapeh ,&nbsp;Jafar Rezaie ,&nbsp;Vahid Nejati","doi":"10.1016/j.arcmed.2025.103194","DOIUrl":"10.1016/j.arcmed.2025.103194","url":null,"abstract":"<div><h3>Background</h3><div>Due to their unique properties, extracellular vesicles (EVs) are promising nanocarriers for exogenous drug delivery.</div></div><div><h3>Aim</h3><div>We prepared a drug delivery system based on large EVs (LEVs) containing paclitaxel (PTX) (LEVs-PTX) to investigate anticancer effects on lung cancer cells with a focus on autophagy.</div></div><div><h3>Methods</h3><div>LEVs-PTX were isolated from lung cancer cells by ultracentrifugation and characterized using different techniques. Rhodamine B dye (Rh B) was used to label LEVs-PTX for cell tracking. MTT assay was performed to investigate the cellular toxicity of PTX and LEVs-PTX for 24 h and 48 h. The uptake of LEVs-PTX was monitored by immunofluorescence microscopy in breast and lung cancer cells. A colorimetric assay was performed to evaluate apoptosis, while Western blotting assays were used to investigate autophagy proteins. Real-time PCR was used to measure mitophagy genes.</div></div><div><h3>Results</h3><div>Characterization techniques showed that LEVs were isolated and loaded with PTX. Rh B labeled LEVs, which was confirmed by a fluorescence spectrophotometer. Immunofluorescence microscopy showed that the lung and breast cancer cells had captured LEVs. Cell viability was decreased in LEVs-PTX cells which coincided with an increase in caspase-3 activity in LEVs-PTX cells. The Beclin-1 protein level and LC3 II/I ratio decreased, while the P62 protein level was increased in LEVs-PTX cells. The mitophagy genes such as Pink-1 and Parkin were upregulated in LEVs-PTX cells.</div></div><div><h3>Conclusion</h3><div>The data show that LEVs-PTX induced apoptosis, which inhibited the autophagy pathway and increased mitophagy markers, suggesting damage to cell organelles through intracellular delivery of PTX.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 4","pages":"Article 103194"},"PeriodicalIF":4.7,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143357048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity and Reliability of the Spanish Version of the General Work Stress Scale in Mexican Medical Residents","authors":"Hid Felizardo Cordero-Franco ,&nbsp;Ana María Salinas-Martínez ,&nbsp;Francisco Javier Guzmán-de la Garza","doi":"10.1016/j.arcmed.2025.103196","DOIUrl":"10.1016/j.arcmed.2025.103196","url":null,"abstract":"<div><h3>Introduction</h3><div>The General Work Stress Scale (GWSS) explores how a worker's feelings, thoughts, and motivations are affected by work pressure. We aimed to evaluate the validity and reliability of the Spanish version of the GWSS in Mexican medical residents.</div></div><div><h3>Methods</h3><div>Cross-sectional study of medical residents of all specialties in a public health institution in Nuevo León, Mexico. They were invited to participate by filling out an anonymous and voluntary online questionnaire (<em>n</em> = 772). Content validity (relevance and usefulness) was evaluated using the Lawshe index (LCVI), while construct validity was assessed with exploratory (EFA) and confirmatory (CFA) factor analysis. The CFA fit indices were RMSEA (root mean square error of approximation), the comparative fit index (CFI), the Tucker-Lewis index (TLI), and the standardized root mean square residual (SRMR). The Spearman correlation coefficient between the GWSS and the Oldenburg Burnout Inventory (OLBI) was estimated for concurrent validity and Cronbach's α for reliability.</div></div><div><h3>Results</h3><div>The GWSS showed content validity (LCVI 0.96 ± 0.08 and 0.90 ± 0.10 for relevance and usefulness, respectively). The EFA showed a unifactorial structure (74.3 % of the variance). The CFA showed a good fit (RMSEA = 0.122 (95 % CI 0.105, 0.140), CFI = 0.958, TLI = 0.942 and SRMR = 0.028). A Cronbach's α of 0.96 and a correlation of 0.65 (<em>p</em> &lt; 0.0001) were obtained.</div></div><div><h3>Conclusions</h3><div>The Spanish version of the GWSS showed content, construct, and concurrent validity, as well as reliability in Mexican medical residents. Testing the GWSS in other specialties and the private sector is recommended.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 3","pages":"Article 103196"},"PeriodicalIF":4.7,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143349531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engaging communities in health promotion through community-based primary care and participatory research during the COVID-19 pandemic in Bolivia","authors":"Christine Leyns ,&nbsp;Carla Ascarrunz ,&nbsp;Shirley Rasguido ,&nbsp;Patricia Rodriguez ,&nbsp;Daniel Eid ,&nbsp;Javier Guitian","doi":"10.1016/j.arcmed.2024.103154","DOIUrl":"10.1016/j.arcmed.2024.103154","url":null,"abstract":"<div><h3>Background</h3><div>Most people in low- and middle-income countries work in the informal sector and lack social protection. In Bolivia, the unified family, community, and intercultural health model established universal health coverage for informal workers and their families in 2019. The COVID-19 pandemic, which occurred soon after, exposed both the vulnerabilities and the strengths of this health policy.</div></div><div><h3>Aim</h3><div>To describe the community-based design of a health promotion strategy based on people-centered and participatory research within a vulnerable community of informal market vendors during the COVID-19 pandemic.</div></div><div><h3>Methods</h3><div>As part of participatory action research during the COVID-19 pandemic, market vendors collaborated with a multidisciplinary research team, local authorities, and the health network to promote health and safety in their markets. Market vendors developed a health promotion strategy facilitated by a highly structured mixed qualitative-quantitative concept mapping approach and reached a consensus on an operational health strategy with measurable goals, actions, timelines, and actors.</div></div><div><h3>Results</h3><div>A community health diagnosis together with health education and individualized clinical care, created a common understanding of health and built trust between the community and the research/health team. Market vendors identified health needs related to care access, self-care, market organization, and the social determinants of health, including strategies to prevent infections, reduce cardiometabolic risk, and improve mental health.</div></div><div><h3>Conclusions</h3><div>Effective strategies to promote health or to manage health crises such as a pandemic can be developed by organized communities in primary care supported by individual and collective health data, health education, and the integration of social scientists, epidemiologists, and health professionals.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 3","pages":"Article 103154"},"PeriodicalIF":4.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Comment on “Features and Allele Frequency of JAK2 Exon 12-mutated Polycythemia Vera and a Comparison With JAK2V617F-mutated Disease”","authors":"Chin-Hsuan Chuang ,&nbsp;Ming-Chung Kuo ,&nbsp;Lee-Yung Shih","doi":"10.1016/j.arcmed.2024.103178","DOIUrl":"10.1016/j.arcmed.2024.103178","url":null,"abstract":"","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 4","pages":"Article 103178"},"PeriodicalIF":4.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of secondary fractures after implementation of different models of FLS secondary prevention programs: Scoping review","authors":"Patricia Clark ,&nbsp;Lucía Méndez-Sánchez ,&nbsp;Eliseo Ramírez-García ,&nbsp;Sergio Sánchez-García ,&nbsp;Adriana Medina ,&nbsp;Juan Humberto Medina Chávez","doi":"10.1016/j.arcmed.2024.103121","DOIUrl":"10.1016/j.arcmed.2024.103121","url":null,"abstract":"<div><h3>Background</h3><div>As the number of programs aimed at preventing fragility fractures and mitigating the phenomenon of cascade fractures is increasing worldwide, so it is necessary to evaluate the effectiveness of such programs to seek their feasible implementation at regional and global levels.</div></div><div><h3>Aims</h3><div>This paper aims to provide an overview focusing on the incidence of secondary fractures after the implementation of any type of fracture liaison service (FLS). To this end, a scoping review was conducted focusing on the identification of clinical evidence reported in systematic reviews of the medical literature in this area.</div></div><div><h3>Methods</h3><div>A total of 230 titles were obtained through structured searches in four electronic libraries (updated to September 2023), from which a total of 11 systematic reviews were selected.</div></div><div><h3>Results</h3><div>Tables of methodological characteristics were developed. Different programs such as orthogeriatric units, educational strategies, exercise strategies, screening strategies using DXA or FRAX, and specialist intervention by orthopedic specialists or osteoporosis nurses were found in 20 different countries. The reported incidence of secondary fractures varies between populations and strategies compared depending on the data collected and the type of methodological design used. The incidence of secondary fractures in these 11 systematic reviews ranged from 0 to 37 %.</div></div><div><h3>Conclusion</h3><div>The incidence by intervention is described in the Supplementary Tables of the primary studies.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 2","pages":"Article 103121"},"PeriodicalIF":4.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}