Archives of Medical Research最新文献

{"title":"Endocrine Disruptors and Attention Deficit Hyperactivity Disorder: A Systematic Review","authors":"Marta Lopez-Garcia ,&nbsp;Manuel Martinez-Bebia ,&nbsp;Alejandro Lopez-Moro ,&nbsp;Nuria Gimenez-Blasi ,&nbsp;José Antonio Latorre ,&nbsp;Miguel Mariscal-Arcas","doi":"10.1016/j.arcmed.2025.103260","DOIUrl":"10.1016/j.arcmed.2025.103260","url":null,"abstract":"<div><div>The increasing prevalence of attention deficit hyperactivity disorder (ADHD) in children has prompted more research on both genetic and environmental risk factors, including endocrine-disrupting chemicals (EDCs) such as bisphenol A (BPA) and polychlorinated biphenyls (PCBs). This review focuses on studies published between 2013 and December 2023 that explore the potential impact of BPA and PCBs on ADHD. The review draws from databases such as WOS, PubMed, and Scopus. BPA, a chemical commonly used in plastics and resins, has raised concerns due to its potential neurodevelopmental effects, particularly when exposure occurs prenatally. Multiple studies have suggested an association between prenatal BPA exposure and an increased risk of ADHD in offspring, though more research is needed. Similarly, PCBs, which are persistent environmental pollutants primarily found in contaminated food sources, have been linked to cognitive and behavioral issues, including attention deficits and hyperactivity. Both BPA and PCBs have been shown to disrupt neurodevelopment, underscoring the importance of regulating these chemicals to safeguard children’s health. While these findings highlight a potential risk, further studies are required to clarify the underlying mechanisms and the precise role these EDCs play in the development of ADHD and other neurobehavioral disorders.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 7","pages":"Article 103260"},"PeriodicalIF":4.7,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144330691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatial Approach to Cardiac Electrical Dynamics: Evaluation of Surrogate Biomarkers of Differences in Drug-Induced Multichannel Block","authors":"Pablo Daniel Cruces ,&nbsp;Pedro David Arini","doi":"10.1016/j.arcmed.2025.103251","DOIUrl":"10.1016/j.arcmed.2025.103251","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Torsade de Pointes (TdP), a side effect of many marketed drugs, can lead to sudden cardiac death. Regulatory guidelines require quantification of hERG channel block by QT interval prolongation on ECG, although its predictive value remains low. To propose a novel normalization technique for vectorcardiographic loops, enabling improved derivation of conventional and new indices for the robust identification of multiple cardiac ion channel blockades associated with TdP risk.</div></div><div><h3>Methods</h3><div>A robust method was developed to obtain angular parameters from ECG loops by normalizing for baseline drift using principal component analysis. Linear (via differentiation) and angular (via quaternion algebra) velocities were assessed to identify differential features between multichannel and selective hERG-blocking drugs. Furthermore, bidirectional baseline correction allowed more accurate extraction of ECG wave extrema and peaks, improving the robustness of the QT interval and other temporal measurements. The proposed dynamic biomarkers were evaluated in 22 subjects enrolled in a clinical trial of four known QT-prolonging drugs.</div></div><div><h3>Results</h3><div>The two high-risk drugs exhibited drug-induced changes (<em>p</em> &lt; 0.0005) in velocity during ventricular repolarization. Strong calcium or sodium blockers reduced the effect on velocity caused by hERG potassium channel block. A tendency to symmetry of angular values was observed with high-risk drugs. The alternative temporal indices showed a high correlation (<em>r</em> &gt; 0.9) with standard indices. Differences emerged between the T-wave end and the angular velocity marker of ventricular repolarization end.</div></div><div><h3>Conclusion</h3><div>Spatial analysis of cardiac signals and the new dynamic measures could complement current standards and support safer drug development.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 7","pages":"Article 103251"},"PeriodicalIF":4.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144288780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health in the Time of Nature Crisis","authors":"Luis Zambrano ,&nbsp;Constantino González-Salazar","doi":"10.1016/j.arcmed.2025.103256","DOIUrl":"10.1016/j.arcmed.2025.103256","url":null,"abstract":"<div><div>Human health faces significant challenges due to global changes driven by human activities, such as climate change and biodiversity loss. These phenomena can impact the quality of life both independently and together. The United Nations Environmental Program has labeled these changes as a “nature crisis” because they affect various aspects of human life. In this context, health issues can be categorized as direct or indirect effects of the nature crisis. Direct effects: i. Temperature change: Heat waves are rapidly increasing mortality rates. ii. Hydrometeorological hazards: Floods can compromise water quality, creating health risks. iii. Air pollution: Climate change can increase the mobility of pollutants, worsening air quality. Indirect effects: i. Vector-borne diseases: For example, changes in weather patterns can alter the distribution of vectors, such as mosquitoes, affecting disease transmission. ii. Water-borne diseases: Increased incidence of diarrheal diseases can occur as water quality deteriorates. iii. Food-borne diseases: For instance, climate change can increase pathogens in agricultural products, posing health risks. Health impacts vary by regions, and vulnerable populations often have lower adaptive capacities. Health policies must be tailored globally and locally to address these issues, emphasizing protection for the most at-risk groups. Collaboration between the health and environmental sectors is essential to solve these growing problems. However, current adaptation policies are constantly challenged by the nature crisis. Therefore, humanity must intensify its efforts to mitigate climate change and reduce land use changes to preserve biodiversity.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 7","pages":"Article 103256"},"PeriodicalIF":4.7,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144279081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interdisciplinary Vocational Training for Resilient, Integrated, and Person-Centered Health Systems","authors":"Mónica Valenzuela ,&nbsp;Osvaldo Artaza ,&nbsp;Javier Santa Cruz ,&nbsp;Marcelo Fagalde ,&nbsp;Mónica Espinoza ,&nbsp;Sandra Oyarzo ,&nbsp;Erich V. De Paula ,&nbsp;Rogelio Pizzi","doi":"10.1016/j.arcmed.2025.103243","DOIUrl":"10.1016/j.arcmed.2025.103243","url":null,"abstract":"","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 7","pages":"Article 103243"},"PeriodicalIF":4.7,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144279082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased LDH Remains a Crucial Prognostic Factor in Patients With Multiple Myeloma","authors":"Ramiro Espinoza-Zamora ,&nbsp;Nidia Paulina Zapata-Canto ,&nbsp;Lizbeth Deyanir Aguilera-Urbina ,&nbsp;Judith Cruz-Velazquez ,&nbsp;Elba Reyes-Maldonado ,&nbsp;Jorge Vela-Ojeda","doi":"10.1016/j.arcmed.2025.103239","DOIUrl":"10.1016/j.arcmed.2025.103239","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Multiple myeloma is the second most common hematologic cancer and remains incurable. Several prognostic factors have been identified, but many are costly and inaccessible to most hematology centers. To explore the clinical, laboratory, and cytogenetic factors that influence survival in patients with newly diagnosed multiple myeloma.</div></div><div><h3>Methods</h3><div>The research included 286 patients treated with different regimens: 64.5 % received thalidomide-based combinations, while 35.5 % were treated with proteasome inhibitor combinations.</div></div><div><h3>Results</h3><div>Stringent complete remission was achieved in 15.5 %, complete remission in 30.5 %, very good partial response in 41 %, and partial response in 5 %. Progression-free survival (PFS) and overall survival (OS) were lower in patients with high lactate dehydrogenase (LDH), renal disease, <em>t</em>(4;14), RB1 mutation, and in those who did not achieve complete remission or were not treated with transplantation and proteasome inhibitors. Elevated LDH was identified as the most significant independent prognostic factor. A scoring system based on LDH, renal disease, <em>t</em>(4;14), and RB1 mutation was developed and showed differences in PFS and OS based on the score (0,1,2,3, or 4,5 points).</div></div><div><h3>Conclusions</h3><div>An elevated LDH level was the most significant prognostic factor. A simple scoring system is suggested, especially for patients without access to expensive cytogenetic testing.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 6","pages":"Article 103239"},"PeriodicalIF":4.7,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144240190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Semaphorin 7A Induces Liver Inflammation and Promotes Parenteral Nutrition-Associated Cholestasis via ITGβ1/NF-κB Pathway","authors":"Leilei Shen,&nbsp;Xiaodong Sun,&nbsp;Ruixue Zheng,&nbsp;Min Tao,&nbsp;Sheng Chen","doi":"10.1016/j.arcmed.2025.103244","DOIUrl":"10.1016/j.arcmed.2025.103244","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the mechanistic role of semaphorin 7A (Sema7A) in neonatal parenteral nutrition-associated cholestasis (PNAC).</div></div><div><h3>Methods</h3><div>First, we measured the expression levels of Sema7A and inflammatory factors in both neonates with PNAC and rat models. Then, to investigate the mechanism underlying the regulatory role of Sema7A in hepatic inflammatory injury, we assessed NF-κB pathway activation and monitored inflammatory factor variations following Sema7A/integrin β1 (ITGβ1) inhibition and overexpression in rat models and isolated primary Kupffer cells. Furthermore, liver pathology and cholestatic changes were systematically examined by Sema7A manipulation (inhibition and overexpression) in animal models.</div></div><div><h3>Results</h3><div>Neonates and rats with PNAC showed increased levels of TNF-α and IL-1β, and decreased levels of IL-4 and IL-10. Accordingly, Sema7A, ITGβ1, and P65/p-P65 mRNA and protein expression were elevated. In vitro, Sema7A overexpression activated the NF-κB pathway, which was reversible by ITGβ1 inhibition; conversely, Sema7A knockdown attenuated NF-κB activation, which was partially reversible by ITGβ1 overexpression. In vivo, Sema7A overexpression worsened liver injury and cholestasis through activation of the NF-κB pathway, while its inhibition ameliorated these effects.</div></div><div><h3>Conclusions</h3><div>Sema7A activates the NF-κB signaling pathway in an ITGβ1-dependent manner and exacerbates PN-induced liver injury and cholestasis. Targeting Sema7A may provide a therapeutic strategy to alleviate neonatal PNAC.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 7","pages":"Article 103244"},"PeriodicalIF":4.7,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144230295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rivaroxaban Prophylaxis in Peripherally Inserted Central Catheter-Related Thrombosis in Breast Cancer Patients","authors":"Die Sang ,&nbsp;Shiyu Li ,&nbsp;Shanmin Fan ,&nbsp;Jintao Zhang ,&nbsp;Yanfang Su ,&nbsp;Xiaoyan Zhang ,&nbsp;Yinfeng Wang ,&nbsp;Huachao Feng ,&nbsp;Yuzhi Hao ,&nbsp;Yujuan Liu ,&nbsp;Man Li ,&nbsp;Peng Yuan","doi":"10.1016/j.arcmed.2025.103242","DOIUrl":"10.1016/j.arcmed.2025.103242","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the efficacy and safety of rivaroxaban in preventing catheter-related thrombosis (CRT) in breast cancer patients undergoing chemotherapy with peripherally inserted central catheters (PICC).</div></div><div><h3>Methods</h3><div>A prospective cohort study enrolled breast cancer patients who underwent PICC placement for chemotherapy at the San Huan Cancer Hospital from November 2021 to August 2023. The treatment group received 10 mg of oral rivaroxaban daily for 2 months along with routine grip strength training, while the control group received grip strength training only. CRT occurrence was confirmed by vascular ultrasound, and group comparisons were made using the χ² test, with logistic regression analyzing CRT risk factors.</div></div><div><h3>Results</h3><div>Of 314 patients, 181 received treatment and 133 were in the control group. The treatment group had a significantly lower incidence of CRT (2.2 %, 4/181) compared to the control group (12.0 %, 16/133) (<em>p</em> &lt; 0.001). Univariate analysis showed a higher risk of CRT in patients in the non-prophylaxis group (<em>p</em> = 0.002), patients aged ≥50 years (<em>p</em> = 0.014), and those with prior endocrine therapy (<em>p</em> = 0.030). Multivariate analysis identified rivaroxaban prophylaxis (<em>p</em> = 0.009) and age (<em>p</em> = 0.026) as independent risk factors for thrombosis. The use of rivaroxaban for prophylactic anticoagulation was safe. All CRT-diagnosed patients completed their antitumor therapy without new thrombosis or pulmonary embolism.</div></div><div><h3>Conclusion</h3><div>Two months of rivaroxaban prophylaxis effectively and safely reduce CRT incidence in breast cancer patients with PICC.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 6","pages":"Article 103242"},"PeriodicalIF":4.7,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144230982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, Attitudes and Practices Regarding COVID-19 and Its Vaccination in a High School Population","authors":"Mauricio Rodríguez-Álvarez ,&nbsp;Luis Pablo Cruz-Hervert ,&nbsp;María Eugenia Jiménez-Corona ,&nbsp;Norma Mongua-Rodríguez ,&nbsp;María Dolores Valle Martínez ,&nbsp;Benjamín Barajas Sánchez ,&nbsp;Javier Romero y Fuentes ,&nbsp;Lourdes García-García ,&nbsp;Samuel Ponce-de-León-Rosales","doi":"10.1016/j.arcmed.2025.103241","DOIUrl":"10.1016/j.arcmed.2025.103241","url":null,"abstract":"<div><h3>Background</h3><div>The coronavirus disease 2019 (COVID-19) pandemic had a profound impact on education in Mexico, with extended school closures and the shift to distance learning. The absence of an initial vaccine and the general need for evidence on prevention measures within university communities prompted this study.</div></div><div><h3>Objective</h3><div>To assess the knowledge, attitudes, and practices regarding COVID-19 and its vaccination in the high school community (HSC) of the National Autonomous University of Mexico (UNAM) by the third year of the pandemic.</div></div><div><h3>Methods</h3><div>A cross-sectional, 26-question online survey was conducted among UNAM HSC in September 2022. The data were analyzed using multivariate logistic and linear regression models to identify factors associated with vaccination.</div></div><div><h3>Results</h3><div>A total of 22,000 surveys were collected, 16,789 of which were eligible for analysis. Among these, 16,361 (97.4 %) respondents were vaccinated. The primary reason for nonvaccination was the inability to access a vaccine (37.2 %). Younger respondents (&lt;18 years) were more likely to be unvaccinated, 10–14 years, (OR: 5.36; 95 % CI: 2.12–13.55; <em>p</em> &lt; 0.001); and 15–18 years, (OR: 2.77; 95 % CI: 1.12–6.82, <em>p</em> = 0.028). Individuals with overweight/obesity (OR: 1.39; 95 % CI 1.05–1.85; <em>p</em> = 0.023); immunosuppression (OR: 2.6; 95 % CI: 1.56–4.33; <em>p</em> &lt; 0.001), and those who considered these conditions as risk factors for COVID-19 were significantly more likely to be unvaccinated. Conversely, those who viewed hypertension as a risk factor OR 0.7 (95 % CI 0.53–0.93)) or who were accustomed to face mask use OR 0.28 (95 % CI 0.22–0.35), <em>p</em> &lt; 0.001) were more likely to be vaccinated.</div></div><div><h3>Conclusions</h3><div>We found a high acceptance of COVID-19 vaccination at UNAM HSC, which may have contributed to the safer resumption of in-person activities and helped mitigate the impact of subsequent epidemic waves; the reasons for non-vaccination appear addressable through targeted logistical measures and tailored information.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 7","pages":"Article 103241"},"PeriodicalIF":4.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144154389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changing Landscape of Liver Cirrhosis Etiologies","authors":"Nahum Méndez-Sánchez ,&nbsp;Mariana M Ramírez-Mejía ,&nbsp;Ming-Hua Zheng ,&nbsp;Carlos Cortez-Hernández ,&nbsp;Elianee M Tovar-Bojorquez ,&nbsp;Raúl Contreras-Omaña ,&nbsp;Juan D Monsiváis-Morales ,&nbsp;Jacqueline Córdova-Gallardo ,&nbsp;Mauricio Castillo-Barradas ,&nbsp;Nubia Guzmán-Rodríguez ,&nbsp;María S González-Huezo ,&nbsp;Adrian Sandez-Araiza ,&nbsp;Eira Cerda-Reyes ,&nbsp;Stefanny Cornejo-Hernández ,&nbsp;Beatriz Barranco-Fragoso ,&nbsp;Ana D Cano-Contreras ,&nbsp;José M Remes-Troche ,&nbsp;Fatima Higuera-de-la-Tijera ,&nbsp;José L Pérez-Hernández ,&nbsp;Norberto Chávez-Tapia ,&nbsp;Heriberto Rodríguez-Hernández","doi":"10.1016/j.arcmed.2025.103240","DOIUrl":"10.1016/j.arcmed.2025.103240","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Liver cirrhosis is a major public health problem worldwide. In Mexico, the increased prevalence of obesity and type 2 diabetes mellitus (T2DM) has contributed to an increase in the prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD). This study examines the current etiologies of cirrhosis in Mexico, highlighting regional and demographic differences.</div></div><div><h3>Methods</h3><div>We conducted a multicenter cross-sectional study of 2182 patients with cirrhosis diagnosed between 2018 and 2024 in 13 tertiary care hospitals in northern, central, and southern Mexico. Demographic data, etiology, and complications were analyzed.</div></div><div><h3>Results</h3><div>MASLD was the most frequent cause of cirrhosis (42.8 %), followed by alcohol-related liver disease (ALD, 23.8 %) and hepatitis C virus (HCV, 12.2 %). MASLD was more common in older patients and women, while ALD was more frequent in younger patients and men. HCC was observed in 8.9 % of patients, with a higher prevalence in the central region. The most common complications were portal hypertension (59.5 %) and ascites (30.4 %). Regional differences were observed, with a higher prevalence of MASLD in central and southern Mexico, while ALD was more prominent in the northern region.</div></div><div><h3>Conclusion</h3><div>This cross-sectional study underscores the changing etiologies of liver cirrhosis in Mexico, with MASLD emerging as the leading cause, particularly in older patients and women. Regional differences were evident, with ALD being more frequent in younger patients and in men, especially in the northern region.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 7","pages":"Article 103240"},"PeriodicalIF":4.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144154388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to: “Clinical Characteristics and Outcomes of Infective Endocarditis in Patients With Cancer: A Multicenter Case-Control Study”","authors":"Gustavo Méndez-Hirata ,&nbsp;Frida Rivera-Buendía ,&nbsp;Eduardo Viveros-Rentería ,&nbsp;Eric Ochoa-Hein ,&nbsp;Patricia Cornejo-Juárez ,&nbsp;Manlio Márquez ,&nbsp;Jose Ramón Hidalgo-Dura ,&nbsp;Yoana Leyva-López ,&nbsp;Diana Vilar-Compte","doi":"10.1016/j.arcmed.2025.103233","DOIUrl":"10.1016/j.arcmed.2025.103233","url":null,"abstract":"","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 6","pages":"Article 103233"},"PeriodicalIF":4.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144116925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}