Archives of Medical Research最新文献

Strengthening Access to Post-Pandemic Mental Health Care: An Action Proposal 加强获得大流行后精神卫生保健：一项行动建议

IF 4.7 3区医学

Archives of Medical Research Pub Date : 2025-07-10 DOI: 10.1016/j.arcmed.2025.103255

Nicole Lobos-Villatoro, Carlos Güida, Osvaldo Artaza

引用次数: 0

Spironolactone Partially Reverses Autism-Like Behaviors Linked to ErbB4 and mTOR Phosphorylation in the Mouse Prefrontal Cortex and Striatum 螺内酯部分逆转小鼠前额皮质和纹状体中与ErbB4和mTOR磷酸化相关的自闭症样行为

IF 4.7 3区医学

Archives of Medical Research Pub Date : 2025-07-10 DOI: 10.1016/j.arcmed.2025.103254

David Zarate-Lopez , Rosendo García-Carrillo , Luis Castro-Sánchez , Alma Y. Galvez-Contreras , Oscar Gonzalez-Perez

{"title":"Spironolactone Partially Reverses Autism-Like Behaviors Linked to ErbB4 and mTOR Phosphorylation in the Mouse Prefrontal Cortex and Striatum","authors":"David Zarate-Lopez , Rosendo García-Carrillo , Luis Castro-Sánchez , Alma Y. Galvez-Contreras , Oscar Gonzalez-Perez","doi":"10.1016/j.arcmed.2025.103254","DOIUrl":"10.1016/j.arcmed.2025.103254","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Autism spectrum disorder (ASD) is a condition resulting from a combination of genetic and environmental influences that lead to atypical brain development, particularly in regions such as the striatum and prefrontal cortex. There is increasing evidence linking the epidermal growth factor (EGF) and its receptor (EGFR or ErbB1) to the etiopathogenesis of ASD. However, ErbB4, another ErbB member, has also been implicated in this process. To investigate whether dysregulation of ErbB4 and its downstream mTOR signaling pathway in the striatum and prefrontal cortex contributes to stereotypical behaviors and social deficits in an autism-like rodent model.</div></div><div><h3>Methods</h3><div>We analyzed the phosphorylation levels of ErbB4and mTOR in the prefrontal cortex and striatum of 31 d old mice that were prenatally exposed to valproate (VPA; 500 mg/kg) or the control vehicle (0.9 % NaCl). Social and stereotypic behaviors were assessed using the three-chamber social test and the marble burying test, respectively. Then, the VPA groups were treated with 50 mg/kg of spironolactone, a selective ErbB4 antagonist.</div></div><div><h3>Results</h3><div>Prenatal exposure to VPA induced deficits in social interaction and an increase in repetitive behaviors. These behaviors coexist with dysregulation of the ErbB4 phosphorylation and modifications in the mTOR signaling pathway in both brain regions. Treatment with spironolactone reduced repetitive behaviors, which was consistent with reduced ErbB4 phosphorylation and mTOR signaling.</div></div><div><h3>Conclusions</h3><div>These results support the idea that ErbB4 has abnormal expression and activity levels in the striatum and prefrontal cortex. Antagonizing ErbB4 with spironolactone improves repetitive behavioral patterns associated with ASD.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 7","pages":"Article 103254"},"PeriodicalIF":4.7,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144589100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of Cyclosporin A and Tacrolimus in The Treatment of Endometriosis of Rats 环孢素A联合他克莫司治疗大鼠子宫内膜异位症的疗效观察

IF 4.7 3区医学

Archives of Medical Research Pub Date : 2025-07-09 DOI: 10.1016/j.arcmed.2025.103258

Cagla Bahar Bulbul , Gulay Turan , Ceyda Sancakli Usta , Ozgur Bulmus , Akin Usta

{"title":"Efficacy of Cyclosporin A and Tacrolimus in The Treatment of Endometriosis of Rats","authors":"Cagla Bahar Bulbul , Gulay Turan , Ceyda Sancakli Usta , Ozgur Bulmus , Akin Usta","doi":"10.1016/j.arcmed.2025.103258","DOIUrl":"10.1016/j.arcmed.2025.103258","url":null,"abstract":"<div><h3>Background and Aims</h3><div>The molecular and cellular mechanisms underlying endometriosis are still under investigation. Cyclophilin A (CypA) is an inflammatory marker secreted by various types of cells in an inflammatory condition. During inflammation, CypA exacerbates the inflammatory response by activating calcineurin signaling, which increases cytokine secretion and tissue degradation in the inflammatory region. This study investigated the effect of inhibiting calcineurin signaling in treating endometriosis in rats.</div></div><div><h3>Methods</h3><div>Thirty-two albino Wistar rats were used in this study. All rats were divided into three groups: cyclosporin A (<em>n</em> = 10), tacrolimus (<em>n</em> = 10) and a control group (<em>n</em> = 12). The cyclosporin A (CsA) group received two intraperitoneal doses two weeks apart, and the tacrolimus group received the same two doses intravenously, also two weeks apart. All studies lasted eight weeks. The processed endometrial tissues were cut in half and embedded in paraffin. Histological sections (5 µm) were stained with Ki-67, Bcl-2, caspase-3 and VEGF.</div></div><div><h3>Results</h3><div>The endometriotic focus size was 204.7 ± 153.4 mm<sup>3</sup>, 71.9 ± 85.4 mm<sup>3</sup>, and 30.6 ± 36.7 mm<sup>3</sup> in the control, CsA, and tacrolimus groups, respectively. Compared to the control group, the endometriotic focus size was smaller in the CsA and tacrolimus groups (<em>p</em> = 0.002). Microscopically, Ki-67 (<em>p</em> = 0.010) and VEGF (<em>p</em> = 0.007) immunoreactivity were lower in the CsA and tacrolimus groups than in controls.</div></div><div><h3>Conclusions</h3><div>The inhibition of calcineurin signaling with CsA or tacrolimus treatment causes regression of the endometriotic focus by decreasing endometriotic cell proliferation and angiogenesis in ectopic endometriotic tissue.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 7","pages":"Article 103258"},"PeriodicalIF":4.7,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144589053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Catheter Ablation of Triggers and Arrhythmogenic Epicardial Substrates in Patients With QT Prolongation QT延长患者心外膜底物和诱发心律失常的导管消融

IF 4.7 3区医学

Archives of Medical Research Pub Date : 2025-07-01 DOI: 10.1016/j.arcmed.2025.103257

Yoga Yuniadi, Dicky A. Hanafy, Sunu B. Raharjo, Dony Y. Hermanto

{"title":"Catheter Ablation of Triggers and Arrhythmogenic Epicardial Substrates in Patients With QT Prolongation","authors":"Yoga Yuniadi, Dicky A. Hanafy, Sunu B. Raharjo, Dony Y. Hermanto","doi":"10.1016/j.arcmed.2025.103257","DOIUrl":"10.1016/j.arcmed.2025.103257","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Long QT syndrome (LQTS) ablation is currently limited to high-risk or refractory cases, targeting the elimination of triggers such as ventricular premature contraction (VPC). However, the characteristics of the underlying substrate and the role of radiofrequency ablation have not been extensively discussed.</div></div><div><h3>Methods and Results</h3><div>Eight symptomatic patients with LQTS (all women; aged 36 ± 10.2 years) underwent 3-D endocardial and epicardial mapping of triggers and/or substrates of ventricular arrhythmias. Genetic testing revealed P1093A mutations in the <em>KCNH2</em> gene, H558R mutations in the <em>SCN5A</em> gene, and K28E mutations in the <em>KCNH2</em> gene in three patients, respectively. A total of 13 VPC morphologies were identified, including five right ventricular outflow tract (RVOT) VPCs, one basal lateral RV, two from inferoapical RV, one from the lateral to annulus tricuspid, three from basal lateral LV and one from epicardial site of the lateral mitral annulus. Epicardial voltage mapping revealed moderate to extensive areas of scar and low voltage in all patients. The localized abnormal ventricular activities (LAVAs) were recorded in all patients and were successfully ablated. The corrected QT interval (QTc) shortened after the epicardial LAVA elimination (594.9 ± 85.98 ms vs. 490 ± 67.49 ms, <em>p</em> = 0.001). During a mean follow-up period of 288 ± 147.4 d (range 170–492 d), two patients experienced ventricular tachycardia (VT) /ventricular fibrillation (VF) recurrence.</div></div><div><h3>Conclusion</h3><div>Regional and limited epicardial LAVAs could be identified in patients with LQTS. Radiofrequency ablation of VPC triggers and epicardial LAVAs had a modest effect on preventing future VT/VF recurrences.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 7","pages":"Article 103257"},"PeriodicalIF":4.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144517925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between ACE Gene I/D Polymorphism and Diabetic Retinopathy in Mexican Population ACE基因I/D多态性与墨西哥人群糖尿病视网膜病变的关系

IF 4.7 3区医学

Archives of Medical Research Pub Date : 2025-06-30 DOI: 10.1016/j.arcmed.2025.103252

Karla Barrera-Perales , Héctor Pérez-Cano , Sergio Rojas-Juárez , Oscar Morales-López , Alin Somilleda-Ventura , Miguel Angel Cuevas-Budhart , Rogelio Ivan Silva Rueda

{"title":"Association Between ACE Gene I/D Polymorphism and Diabetic Retinopathy in Mexican Population","authors":"Karla Barrera-Perales , Héctor Pérez-Cano , Sergio Rojas-Juárez , Oscar Morales-López , Alin Somilleda-Ventura , Miguel Angel Cuevas-Budhart , Rogelio Ivan Silva Rueda","doi":"10.1016/j.arcmed.2025.103252","DOIUrl":"10.1016/j.arcmed.2025.103252","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Diabetic retinopathy (DR) is a significant ocular complication. The insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme (ACE) gene has been associated with its development.</div></div><div><h3>Objective</h3><div>To evaluate the relationship between the ACE gene I/D polymorphism and the presence of DR to identify the highest-risk allele.</div></div><div><h3>Methods</h3><div>79 patients with diabetic retinopathy and 75 healthy controls were studied. Metabolic and anthropometric measurements were performed, and DNA was extracted to identify the polymorphism using C-reactive protein. Fisher’s exact test was used for comparative analysis of allele and genotypic frequencies.</div></div><div><h3>Results</h3><div>The I/I genotype was more frequent in patients with DR (43 %) and was associated with a 3.22-fold increased risk of developing the disease (<em>p</em> = 0.0123). The I allele frequency was 67 % in patients and 56 % in controls, though no significant difference was found (<em>p</em> = 0.073).</div></div><div><h3>Conclusions</h3><div>The higher frequency of the I/I genotype in patients with DR suggests that this genotype may be a risk factor for developing the disease in patients with type 2 diabetes (T2DM). Further studies are recommended to confirm these findings.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 7","pages":"Article 103252"},"PeriodicalIF":4.7,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144514169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endocrine Disruptors and Attention Deficit Hyperactivity Disorder: A Systematic Review 内分泌干扰物与注意缺陷多动障碍：系统综述

IF 4.7 3区医学

Archives of Medical Research Pub Date : 2025-06-21 DOI: 10.1016/j.arcmed.2025.103260

Marta Lopez-Garcia , Manuel Martinez-Bebia , Alejandro Lopez-Moro , Nuria Gimenez-Blasi , José Antonio Latorre , Miguel Mariscal-Arcas

{"title":"Endocrine Disruptors and Attention Deficit Hyperactivity Disorder: A Systematic Review","authors":"Marta Lopez-Garcia , Manuel Martinez-Bebia , Alejandro Lopez-Moro , Nuria Gimenez-Blasi , José Antonio Latorre , Miguel Mariscal-Arcas","doi":"10.1016/j.arcmed.2025.103260","DOIUrl":"10.1016/j.arcmed.2025.103260","url":null,"abstract":"<div><div>The increasing prevalence of attention deficit hyperactivity disorder (ADHD) in children has prompted more research on both genetic and environmental risk factors, including endocrine-disrupting chemicals (EDCs) such as bisphenol A (BPA) and polychlorinated biphenyls (PCBs). This review focuses on studies published between 2013 and December 2023 that explore the potential impact of BPA and PCBs on ADHD. The review draws from databases such as WOS, PubMed, and Scopus. BPA, a chemical commonly used in plastics and resins, has raised concerns due to its potential neurodevelopmental effects, particularly when exposure occurs prenatally. Multiple studies have suggested an association between prenatal BPA exposure and an increased risk of ADHD in offspring, though more research is needed. Similarly, PCBs, which are persistent environmental pollutants primarily found in contaminated food sources, have been linked to cognitive and behavioral issues, including attention deficits and hyperactivity. Both BPA and PCBs have been shown to disrupt neurodevelopment, underscoring the importance of regulating these chemicals to safeguard children’s health. While these findings highlight a potential risk, further studies are required to clarify the underlying mechanisms and the precise role these EDCs play in the development of ADHD and other neurobehavioral disorders.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 7","pages":"Article 103260"},"PeriodicalIF":4.7,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144330691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial Approach to Cardiac Electrical Dynamics: Evaluation of Surrogate Biomarkers of Differences in Drug-Induced Multichannel Block 心电动力学的空间方法：药物诱导的多通道阻滞差异的替代生物标志物的评估

IF 4.7 3区医学

Archives of Medical Research Pub Date : 2025-06-15 DOI: 10.1016/j.arcmed.2025.103251

Pablo Daniel Cruces , Pedro David Arini

{"title":"Spatial Approach to Cardiac Electrical Dynamics: Evaluation of Surrogate Biomarkers of Differences in Drug-Induced Multichannel Block","authors":"Pablo Daniel Cruces , Pedro David Arini","doi":"10.1016/j.arcmed.2025.103251","DOIUrl":"10.1016/j.arcmed.2025.103251","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Torsade de Pointes (TdP), a side effect of many marketed drugs, can lead to sudden cardiac death. Regulatory guidelines require quantification of hERG channel block by QT interval prolongation on ECG, although its predictive value remains low. To propose a novel normalization technique for vectorcardiographic loops, enabling improved derivation of conventional and new indices for the robust identification of multiple cardiac ion channel blockades associated with TdP risk.</div></div><div><h3>Methods</h3><div>A robust method was developed to obtain angular parameters from ECG loops by normalizing for baseline drift using principal component analysis. Linear (via differentiation) and angular (via quaternion algebra) velocities were assessed to identify differential features between multichannel and selective hERG-blocking drugs. Furthermore, bidirectional baseline correction allowed more accurate extraction of ECG wave extrema and peaks, improving the robustness of the QT interval and other temporal measurements. The proposed dynamic biomarkers were evaluated in 22 subjects enrolled in a clinical trial of four known QT-prolonging drugs.</div></div><div><h3>Results</h3><div>The two high-risk drugs exhibited drug-induced changes (<em>p</em> < 0.0005) in velocity during ventricular repolarization. Strong calcium or sodium blockers reduced the effect on velocity caused by hERG potassium channel block. A tendency to symmetry of angular values was observed with high-risk drugs. The alternative temporal indices showed a high correlation (<em>r</em> > 0.9) with standard indices. Differences emerged between the T-wave end and the angular velocity marker of ventricular repolarization end.</div></div><div><h3>Conclusion</h3><div>Spatial analysis of cardiac signals and the new dynamic measures could complement current standards and support safer drug development.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 7","pages":"Article 103251"},"PeriodicalIF":4.7,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144288780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Health in the Time of Nature Crisis 自然危机时期的健康

IF 4.7 3区医学

Archives of Medical Research Pub Date : 2025-06-14 DOI: 10.1016/j.arcmed.2025.103256

Luis Zambrano , Constantino González-Salazar

{"title":"Health in the Time of Nature Crisis","authors":"Luis Zambrano , Constantino González-Salazar","doi":"10.1016/j.arcmed.2025.103256","DOIUrl":"10.1016/j.arcmed.2025.103256","url":null,"abstract":"<div><div>Human health faces significant challenges due to global changes driven by human activities, such as climate change and biodiversity loss. These phenomena can impact the quality of life both independently and together. The United Nations Environmental Program has labeled these changes as a “nature crisis” because they affect various aspects of human life. In this context, health issues can be categorized as direct or indirect effects of the nature crisis. Direct effects: i. Temperature change: Heat waves are rapidly increasing mortality rates. ii. Hydrometeorological hazards: Floods can compromise water quality, creating health risks. iii. Air pollution: Climate change can increase the mobility of pollutants, worsening air quality. Indirect effects: i. Vector-borne diseases: For example, changes in weather patterns can alter the distribution of vectors, such as mosquitoes, affecting disease transmission. ii. Water-borne diseases: Increased incidence of diarrheal diseases can occur as water quality deteriorates. iii. Food-borne diseases: For instance, climate change can increase pathogens in agricultural products, posing health risks. Health impacts vary by regions, and vulnerable populations often have lower adaptive capacities. Health policies must be tailored globally and locally to address these issues, emphasizing protection for the most at-risk groups. Collaboration between the health and environmental sectors is essential to solve these growing problems. However, current adaptation policies are constantly challenged by the nature crisis. Therefore, humanity must intensify its efforts to mitigate climate change and reduce land use changes to preserve biodiversity.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 7","pages":"Article 103256"},"PeriodicalIF":4.7,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144279081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interdisciplinary Vocational Training for Resilient, Integrated, and Person-Centered Health Systems 跨学科的职业培训弹性，综合的，以人为本的卫生系统

IF 4.7 3区医学

Archives of Medical Research Pub Date : 2025-06-14 DOI: 10.1016/j.arcmed.2025.103243

Mónica Valenzuela , Osvaldo Artaza , Javier Santa Cruz , Marcelo Fagalde , Mónica Espinoza , Sandra Oyarzo , Erich V. De Paula , Rogelio Pizzi

引用次数: 0

Increased LDH Remains a Crucial Prognostic Factor in Patients With Multiple Myeloma LDH升高仍然是多发性骨髓瘤患者预后的关键因素

IF 4.7 3区医学

Archives of Medical Research Pub Date : 2025-06-09 DOI: 10.1016/j.arcmed.2025.103239

Ramiro Espinoza-Zamora , Nidia Paulina Zapata-Canto , Lizbeth Deyanir Aguilera-Urbina , Judith Cruz-Velazquez , Elba Reyes-Maldonado , Jorge Vela-Ojeda

{"title":"Increased LDH Remains a Crucial Prognostic Factor in Patients With Multiple Myeloma","authors":"Ramiro Espinoza-Zamora , Nidia Paulina Zapata-Canto , Lizbeth Deyanir Aguilera-Urbina , Judith Cruz-Velazquez , Elba Reyes-Maldonado , Jorge Vela-Ojeda","doi":"10.1016/j.arcmed.2025.103239","DOIUrl":"10.1016/j.arcmed.2025.103239","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Multiple myeloma is the second most common hematologic cancer and remains incurable. Several prognostic factors have been identified, but many are costly and inaccessible to most hematology centers. To explore the clinical, laboratory, and cytogenetic factors that influence survival in patients with newly diagnosed multiple myeloma.</div></div><div><h3>Methods</h3><div>The research included 286 patients treated with different regimens: 64.5 % received thalidomide-based combinations, while 35.5 % were treated with proteasome inhibitor combinations.</div></div><div><h3>Results</h3><div>Stringent complete remission was achieved in 15.5 %, complete remission in 30.5 %, very good partial response in 41 %, and partial response in 5 %. Progression-free survival (PFS) and overall survival (OS) were lower in patients with high lactate dehydrogenase (LDH), renal disease, <em>t</em>(4;14), RB1 mutation, and in those who did not achieve complete remission or were not treated with transplantation and proteasome inhibitors. Elevated LDH was identified as the most significant independent prognostic factor. A scoring system based on LDH, renal disease, <em>t</em>(4;14), and RB1 mutation was developed and showed differences in PFS and OS based on the score (0,1,2,3, or 4,5 points).</div></div><div><h3>Conclusions</h3><div>An elevated LDH level was the most significant prognostic factor. A simple scoring system is suggested, especially for patients without access to expensive cytogenetic testing.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 6","pages":"Article 103239"},"PeriodicalIF":4.7,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144240190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0