Archives of Medical Research最新文献

{"title":"Response to: Comment on “Impaired Ischemia-Reperfusion Responses in the Hearts of Aged Male and Female Offspring of Obese Rats”","authors":"Carlos A. Ibáñez , Elena Zambrano","doi":"10.1016/j.arcmed.2024.103111","DOIUrl":"10.1016/j.arcmed.2024.103111","url":null,"abstract":"","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 2","pages":"Article 103111"},"PeriodicalIF":4.7,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive Frailty and Aging: Clinical Characteristics, Pathophysiological Mechanisms, and Potential Prevention Strategies","authors":"Sara Gloria Aguilar-Navarro ,&nbsp;Alberto José Mimenza-Alvarado ,&nbsp;Sara Gabriela Yeverino-Castro ,&nbsp;Sandra Milena Caicedo-Correa ,&nbsp;Carlos Cano-Gutiérrez","doi":"10.1016/j.arcmed.2024.103106","DOIUrl":"10.1016/j.arcmed.2024.103106","url":null,"abstract":"<div><div>Frailty has been conceptualized not only as a physical disease, but also as a multidomain entity that encompasses a multimorbid status, disability, cognitive impairment, psychosocial risk factors, and even geriatric syndromes. In addition to physical ailments and depending on the diagnostic model. Standardized neuropsychological tests can identify cognitive deficiencies along with mild cognitive impairment, a pre-dementia stage characterized by memory and/or other cognitive domain impairments with relatively preserved instrumental activities of daily living. Hence, the possibility of cognitive frailty (CF), a construct that refers to physical frailty in concurrence with non-dementia cognitive decline, is proposed. The estimated prevalence of CF ranges from 10.3 to 42.8%. It is likely that the pathway to overt cognitive impairment, which does not yet involve physical function, begins with the asymptomatic early accumulation of progressive brain damage. Thus, timely detection strategies that target the initial phases of CF are warranted. The pathophysiological components of CF include dysregulation of the hypothalamic-pituitary axis stress response, imbalance in energy metabolism, impaired cardiovascular function, mitochondrial deterioration, and vascular age-related arterial stiffness. Changes that contribute to this disease can also occur at the cellular level, including overexpression of the renin-angiotensin-aldosterone system, activation of proinflammatory pathways, endothelial dysfunction, reduced nitric oxide production, and increased oxidative stress. Non-pharmacological interventions, that range from dietary and nutritional counseling to psychosocial therapy, are currently the main approaches. Both cognitive and physical training programs are considered to be the best researched and most useful multidomain interventions. Clinicians recognize CF as a valid concept that warrants prevention and treatment strategies supported by current research.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 1","pages":"Article 103106"},"PeriodicalIF":4.7,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of maternal hormone profile and paternal sperm DNA fragmentation on clinical outcomes following assisted reproduction","authors":"Khashayar Aflatoonian ,&nbsp;Fatemehsadat Amjadi ,&nbsp;Nadia Sheibak ,&nbsp;Maryam Moradi ,&nbsp;Abbas Aflatoonian ,&nbsp;Maryamsadat Tabatabaei ,&nbsp;Katayon Berjis ,&nbsp;Reza Aflatoonian ,&nbsp;Zahra Zandieh","doi":"10.1016/j.arcmed.2024.103108","DOIUrl":"10.1016/j.arcmed.2024.103108","url":null,"abstract":"<div><h3>Background</h3><div>Success of assisted reproductive techniques depends on multiple factors including maternal endocrine status, hormonal balance, and paternal sperm quality. A comprehensive pre-treatment evaluation allows better prediction of outcomes and avoidance of unnecessary procedures and expenses.</div></div><div><h3>Methods</h3><div>To examine the impact of female hormonal profiles and sperm DNA damage on the success of assisted reproduction, medical data were extracted from the clinical records of infertile couples including couples’ age and levels of maternal anti-Mullerian hormone (AMH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and prolactin (PRL), as well as the DNA fragmentation index (DFI) in men. Any correlation between these parameters and clinical outcomes was investigated.</div></div><div><h3>Results</h3><div>DFI and FSH independently influenced the rate of high-quality embryos. A decrease in maternal age and PRL levels increased the rate of these embryos. On the other hand, an increase in maternal body mass index (BMI) or AMH levels was associated with a reduced chance of achieving high quality embryos. In addition, any reduction in PRL levels could be associated with a higher fertilization rate. FSH levels above the normal range contribute to a reduced rate of high-quality embryos. Overall, our findings demonstrate the complex interplay between different factors and their influence on fertilization success and emphasize the importance of optimizing these variables to achieve the best possible outcome.</div></div><div><h3>Conclusion</h3><div>Several factors can influence the outcome of infertility treatment. These factors include paternal DFI, maternal age, BMI, AMH, FSH, and PRL levels.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"55 8","pages":"Article 103108"},"PeriodicalIF":4.7,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of hormonal factors, number of sexual partners, surgical intervention on gastrointestinal and urogenital microbiota of patients endometriosis","authors":"Han Do ,&nbsp;Paula Diaz-Sylvester ,&nbsp;Kathleen Groesch ,&nbsp;Teresa Wilson ,&nbsp;Kristen Delfino ,&nbsp;J.Ricardo Loret de Mola ,&nbsp;Andrea Braundmeier-Fleming","doi":"10.1016/j.arcmed.2024.103112","DOIUrl":"10.1016/j.arcmed.2024.103112","url":null,"abstract":"<div><h3>Problem</h3><div>Endometriosis is associated with gastrointestinal (GI) and urogenital (UG) microbial dysbiosis in patients with endometriosis (P-EOSIS). Sexual partner exposure may contribute to microbial dysbiosis but has not been studied in P-EOSIS. We hypothesized that sexual partner number, hormonal and surgical therapy would affect GI/UG microbial dysbiosis in P-EOSIS.</div></div><div><h3>Methods of Study</h3><div>Urine, fecal and vaginal swabs from control (<em>n</em> = 15) and P-EOSIS (<em>n</em> = 33) were collected on the day of surgery (DOS) and ∼1–3 weeks post-surgical intervention (PSI).</div><div>Control and P-EOSIS were grouped based on hormonal therapy (HT) to determine the effect of HT on microbial profiles, Control (HT <em>n</em> = 8; no HT <em>n</em> = 7) and P-EOSIS (HT <em>n</em> = 18; no HT <em>n</em> = 15). Samples underwent DNA extraction and sequencing of the V4 region of 16S rRNA gene. Sequences were processed using QIIME2 and amplicon sequence variants (ASV) were analyzed for microbial differences. Pearson's and Spearman correlation analyses determined associations among microbial features and sexual partner exposure.</div></div><div><h3>Results</h3><div>P-EOSIS had microbial dysbiosis characterized by unique GI/UG bacteria and altered microbial richness and diversity. Hormonal and surgical intervention in P-EOSIS restored GI microbial diversity. Increased sexual partner exposure decreased GI/UG microbial diversity. P-EOSIS who had 10 or more sexual partners had greater microbial dysbiosis compared to 4–6 partners. Surgical intervention negatively correlated with sexual partner numbers and GI/UG microbial abundance.</div></div><div><h3>Discussion</h3><div>Increased sexual partner exposure may enhance microbial dysbiosis in P-EOSIS and diminish the effectiveness of HT and surgical interventions.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"55 8","pages":"Article 103112"},"PeriodicalIF":4.7,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142578570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relevance of Circulating microRNA, and their Association with Islet Cell Autoantibodies in Type 1 Diabetes Pathogenesis","authors":"Aritania S. Santos ,&nbsp;Daniele Pereira Santos-Bezerra ,&nbsp;Ludmila Rodrigues Pinto Ferreira ,&nbsp;Silvia Y. Bando ,&nbsp;Laís Isidoro Alves ,&nbsp;Edecio Cunha-Neto ,&nbsp;Maria Elizabeth Rossi da Silva","doi":"10.1016/j.arcmed.2024.103114","DOIUrl":"10.1016/j.arcmed.2024.103114","url":null,"abstract":"<div><h3>Background. Aims/hypothesis</h3><div>The role of microRNAs (miRNAs) in the pathogenesis and progression of type 1 diabetes (T1D) has been described, but data remain scarce and conflicting.</div></div><div><h3>Objectives</h3><div>To evaluate the potential biological involvement of miRNA expression in the immune response and beta cell function in T1D.</div></div><div><h3>Methods</h3><div>We screened 10 serum miRNAs from 142 subjects divided into three groups: healthy individuals (control group; <em>n</em> = 52) and patients at different stages of T1D progression, from the initial immunological manifestation, presenting islet cell autoantibodies (AbP group; <em>n</em> = 39), to partial and severe beta cell damage in T1D (recent T1D group; <em>n</em> = 51).</div></div><div><h3>Results</h3><div>Three miRNAs (miR-200c-3p, miR-301a-3p, and miR-382–5p) were highly expressed in the AbP and/or recent T1D groups compared to the control group. Furthermore, in the AbP group, miR-301a-3p and miR-382–5p were positively correlated with insulin autoantibody levels and miR-382–5p was negatively correlated with C-peptide levels. In the recent T1D group, miR-200c-3p expression was positively correlated with IA-2A levels. Enrichment analysis of differentially expressed miRNAs showed their involvement in immune response, inflammatory pathways, proliferation/survival/apoptosis mechanisms, bacterial and viral infection, and insulin resistance.</div></div><div><h3>Conclusion</h3><div>Our data indicated that miR-200c-3p, miR-301a-3p, and miR-382–5p might be involved in T1D pathogenesis. Proliferative, metabolic, and immune responses were main pathways associated with serum miRNA target genes.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 2","pages":"Article 103114"},"PeriodicalIF":4.7,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features and allele frequency of JAK2 Exon 12-mutated polycythemia vera in comparison with JAK2V617F-mutated disease","authors":"Chin-hsuan Chuang ,&nbsp;Ming-chung Kuo ,&nbsp;Jin-hou Wu ,&nbsp;Tung-liang Lin ,&nbsp;Po-nan Wang ,&nbsp;Yueh-shih Chang ,&nbsp;Tung-hui Lin ,&nbsp;Ting-yu Huang ,&nbsp;Yu-shin Hung ,&nbsp;Hsiao-wen Kao ,&nbsp;Che-wei OU ,&nbsp;Hung Chang ,&nbsp;Lee-yung Shih","doi":"10.1016/j.arcmed.2024.103109","DOIUrl":"10.1016/j.arcmed.2024.103109","url":null,"abstract":"<div><h3>Background and Aim</h3><div><em>JAK2</em> exon 12 mutation status and the clinical characteristics of patients with polycythemia vera (PV) in Asia remain to be defined.</div></div><div><h3>Method</h3><div>We analyzed the clinical, molecular, and genetic features and outcomes of patients with PV harboring exon 12 mutation and compared them with the <em>JAK2</em>V617F-mutated patients in Taiwan. <em>JAK2</em>V617F with allele burden was measured by pyrosequencing and/or RT/qPCR. The allele frequency of exon 12 mutation was analyzed by next-generation sequencing in <em>JAK2</em>V617F-negative patients.</div></div><div><h3>Results</h3><div>A total of 532 patients diagnosed with PV were enrolled. The <em>JAK2</em>V617F mutation was present in 94.9% and exon 12 mutations in 5.1%. At diagnosis, patients with exon 12 mutation had higher hemoglobin (<em>p</em> = 0.012), and hematocrit levels (<em>p</em> = 0.003), and lower platelet (<em>p</em> &lt; 0.001), and leukocyte counts (<em>p</em> &lt; 0.001) compared to patients with <em>JAK2</em>V617F mutations. Patients harboring the <em>JAK2</em>V617F mutation had a higher incidence of high allele burden (<em>p</em> &lt; 0.001), disease risk (<em>p</em> <em>=</em> 0.014), and bleeding events <em>(p</em> <em>=</em> 0.013) compared to patients with PV with exon 12 mutations. These patients showed similar outcomes (overall survival, leukemia-free, myelofibrosis and thrombosis-free survival) to those with <em>JAK2</em>V617F mutations. An allele frequency ≥ 52.5% conferred an inferior overall survival compared to ≤ 52.5% in both exon 12-mutated (<em>p</em> = 0.029) and <em>JAK2</em>V617F patients with PV (<em>p</em> = 0.038).</div></div><div><h3>Conclusion</h3><div>Taiwanese patients with PV showed differences in blood count, risk group, and bleeding events between exon 12 and <em>JAK2</em>V617F patients. Higher mutant allele burden had a negative impact on overall survival for both mutation types.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 2","pages":"Article 103109"},"PeriodicalIF":4.7,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142514555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overview of hyperprolactinemia: General approach and reproductive health implications","authors":"Fabian Haidenberg-David,&nbsp;Jessica Sidauy-Adissi,&nbsp;Alberto Moscona-Nissan,&nbsp;Esbeydi Jonguitud-Zumaya,&nbsp;Montserrat Fugarolas-Morinelli,&nbsp;Florencia Martinez-Mendoza,&nbsp;Keiko Taniguchi-Ponciano,&nbsp;Daniel Marrero-Rodríguez,&nbsp;Moises Mercado","doi":"10.1016/j.arcmed.2024.103102","DOIUrl":"10.1016/j.arcmed.2024.103102","url":null,"abstract":"<div><div>Prolactin (PRL) is a polypeptide hormone produced by the lactotrope cells of the anterior pituitary gland. Among its myriads of biological functions, PRL is the main regulator of mammary gland growth and development, as well as of the production and secretion of milk. Hyperprolactinemia represents a frequent consultation cause in medical practice. Nevertheless, elevations in serum PRL are not always pathological. Drug induced hyperprolactinemia is the most common cause, mainly by antipsychotics, followed by other causes such as pituitary neuroendocrine tumors, physiologic conditions, and systemic diseases such as chronic kidney disease and hypothyroidism. When evaluating a patient with hyperprolactinemia it is of utmost importance to consider the diverse etiologies of this condition in order to avoid unnecessary diagnostic workup and treatment. Regarding reproductive health, hyperprolactinemia is a well-documented cause of infertility, as approximately 15-20% of women undergoing infertility evaluation have hyperprolactinemia, which causes secondary amenorrhea, and other menstrual irregularities. Similarly, in men it is a cause of hypogonadism.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"55 8","pages":"Article 103102"},"PeriodicalIF":4.7,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142514551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lethal synergistic infections by two concurrent respiratory pathogens","authors":"Kevin Roe","doi":"10.1016/j.arcmed.2024.103101","DOIUrl":"10.1016/j.arcmed.2024.103101","url":null,"abstract":"<div><div>Lethal synergistic infections by concurrent pathogens have occurred in humans, including human immunodeficiency virus and <em>Mycobacterium tuberculosis</em> infections, or in animal or human models of influenza virus, or bacteria, e.g., <em>Streptococcus pneumoniae</em>, concurrent with severe acute respiratory syndrome coronavirus 2 (SARS–CoV–2). However, the intracellular synergistic interaction possibilities between two respiratory viral pathogens, or between viral and fungal pathogens, merits additional examination. The requirements for synergistic concurrent pathogen infections are: a) relatively little detrimental interference between two pathogens, b) one pathogen having the capability of directly or indirectly assisting the second pathogen by direct immuno–manipulation or indirect provision of infection opportunities and/or metabolic assistance, c) substantial human or environmental prevalence, possibly including a prevalence in any type of health–care facilities or other locations having congregations of potentially infected human or animal vectors and d) substantial transmissibility of the pathogens, which would make their concurrent pathogen infections much more probable. A new definition of pathogen synergy is proposed: “pathogen synergy is an interaction of two or more pathogens during concurrent infections causing an increased infection severity compared to mono–infections by the individual pathogens.” Non–respiratory pathogens can also concurrently infect organs besides the lungs. However, the air–transmissible respiratory pathogens, particularly the RNA viruses, can enable highly widespread and synergistic concurrent infections. For instance, certain strains of coronaviruses, influenza viruses and similar respiratory viruses, are highly transmissible and/or widely prevalent in various vectors for transmission to humans and have numerous capabilities for altering lung immune defenses.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 1","pages":"Article 103101"},"PeriodicalIF":4.7,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142514552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strengthening public health systems during an emerging respiratory disease pandemic: A realist review","authors":"Zahra Afshar Hosseinabadi ,&nbsp;Mostafa Amini-Rarani ,&nbsp;Mohammadreza Amiresmaili ,&nbsp;Nasrin Shaarbafchizadeh ,&nbsp;Ahmad Reza Raeisi","doi":"10.1016/j.arcmed.2024.103096","DOIUrl":"10.1016/j.arcmed.2024.103096","url":null,"abstract":"<div><div>The recent outbreak of respiratory diseases such as COVID-19 has highlighted the need to strengthen public health systems to respond effectively to such crises. While previous research has identified various public health interventions for pandemics, there remains a significant gap in understanding which interventions can strengthen public health systems during emerging respiratory pandemics and under what conditions. To address this gap, we conducted a realist review to examine public health interventions during emerging respiratory disease pandemics, focusing on context, mechanisms, and outcomes. We conducted a literature search across PubMed, Scopus, ProQuest, and Web of Science for studies published since 2003. Finally, we analyzed and assessed the quality of 601 articles and analyzed 32 of them.</div><div>This study emphasizes the importance of understanding the situational, structural, cultural, and environmental contexts that influence public health interventions within the six building blocks of public health systems. We have also identified the mechanisms of these interventions at the individual, organizational, and national levels for successful outcomes, such as improved access to health services, health equity, and effectiveness.</div><div>This information is important for policymakers and practitioners who can use it to develop evidence-based strategies to strengthen public health systems during emerging respiratory disease pandemics. Our review introduced a new conceptual model to explore the interaction between context, interventions, mechanisms, and outcomes to strengthen public health systems. However, further research is needed to determine the effect of specific contextual factors on public health system interventions during respiratory disease pandemics.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 2","pages":"Article 103096"},"PeriodicalIF":4.7,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142514557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: “Impaired Ischemia-Reperfusion Responses in the Hearts of Aged Male and Female Offspring of Obese Rats”","authors":"Eduardo Perez-Campos ,&nbsp;Laura Pérez-Campos Mayoral ,&nbsp;María Teresa Hernández-Huerta ,&nbsp;Hector A. Cabrera-Fuentes","doi":"10.1016/j.arcmed.2024.103110","DOIUrl":"10.1016/j.arcmed.2024.103110","url":null,"abstract":"","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 2","pages":"Article 103110"},"PeriodicalIF":4.7,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142514554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}