Archives of Medical Research最新文献

{"title":"Semaphorin 7A Induces Liver Inflammation and Promotes Parenteral Nutrition-Associated Cholestasis via ITGβ1/NF-κB Pathway","authors":"Leilei Shen,&nbsp;Xiaodong Sun,&nbsp;Ruixue Zheng,&nbsp;Min Tao,&nbsp;Sheng Chen","doi":"10.1016/j.arcmed.2025.103244","DOIUrl":"10.1016/j.arcmed.2025.103244","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the mechanistic role of semaphorin 7A (Sema7A) in neonatal parenteral nutrition-associated cholestasis (PNAC).</div></div><div><h3>Methods</h3><div>First, we measured the expression levels of Sema7A and inflammatory factors in both neonates with PNAC and rat models. Then, to investigate the mechanism underlying the regulatory role of Sema7A in hepatic inflammatory injury, we assessed NF-κB pathway activation and monitored inflammatory factor variations following Sema7A/integrin β1 (ITGβ1) inhibition and overexpression in rat models and isolated primary Kupffer cells. Furthermore, liver pathology and cholestatic changes were systematically examined by Sema7A manipulation (inhibition and overexpression) in animal models.</div></div><div><h3>Results</h3><div>Neonates and rats with PNAC showed increased levels of TNF-α and IL-1β, and decreased levels of IL-4 and IL-10. Accordingly, Sema7A, ITGβ1, and P65/p-P65 mRNA and protein expression were elevated. In vitro, Sema7A overexpression activated the NF-κB pathway, which was reversible by ITGβ1 inhibition; conversely, Sema7A knockdown attenuated NF-κB activation, which was partially reversible by ITGβ1 overexpression. In vivo, Sema7A overexpression worsened liver injury and cholestasis through activation of the NF-κB pathway, while its inhibition ameliorated these effects.</div></div><div><h3>Conclusions</h3><div>Sema7A activates the NF-κB signaling pathway in an ITGβ1-dependent manner and exacerbates PN-induced liver injury and cholestasis. Targeting Sema7A may provide a therapeutic strategy to alleviate neonatal PNAC.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 7","pages":"Article 103244"},"PeriodicalIF":4.7,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144230295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rivaroxaban Prophylaxis in Peripherally Inserted Central Catheter-Related Thrombosis in Breast Cancer Patients","authors":"Die Sang ,&nbsp;Shiyu Li ,&nbsp;Shanmin Fan ,&nbsp;Jintao Zhang ,&nbsp;Yanfang Su ,&nbsp;Xiaoyan Zhang ,&nbsp;Yinfeng Wang ,&nbsp;Huachao Feng ,&nbsp;Yuzhi Hao ,&nbsp;Yujuan Liu ,&nbsp;Man Li ,&nbsp;Peng Yuan","doi":"10.1016/j.arcmed.2025.103242","DOIUrl":"10.1016/j.arcmed.2025.103242","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the efficacy and safety of rivaroxaban in preventing catheter-related thrombosis (CRT) in breast cancer patients undergoing chemotherapy with peripherally inserted central catheters (PICC).</div></div><div><h3>Methods</h3><div>A prospective cohort study enrolled breast cancer patients who underwent PICC placement for chemotherapy at the San Huan Cancer Hospital from November 2021 to August 2023. The treatment group received 10 mg of oral rivaroxaban daily for 2 months along with routine grip strength training, while the control group received grip strength training only. CRT occurrence was confirmed by vascular ultrasound, and group comparisons were made using the χ² test, with logistic regression analyzing CRT risk factors.</div></div><div><h3>Results</h3><div>Of 314 patients, 181 received treatment and 133 were in the control group. The treatment group had a significantly lower incidence of CRT (2.2 %, 4/181) compared to the control group (12.0 %, 16/133) (<em>p</em> &lt; 0.001). Univariate analysis showed a higher risk of CRT in patients in the non-prophylaxis group (<em>p</em> = 0.002), patients aged ≥50 years (<em>p</em> = 0.014), and those with prior endocrine therapy (<em>p</em> = 0.030). Multivariate analysis identified rivaroxaban prophylaxis (<em>p</em> = 0.009) and age (<em>p</em> = 0.026) as independent risk factors for thrombosis. The use of rivaroxaban for prophylactic anticoagulation was safe. All CRT-diagnosed patients completed their antitumor therapy without new thrombosis or pulmonary embolism.</div></div><div><h3>Conclusion</h3><div>Two months of rivaroxaban prophylaxis effectively and safely reduce CRT incidence in breast cancer patients with PICC.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 6","pages":"Article 103242"},"PeriodicalIF":4.7,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144230982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, Attitudes and Practices Regarding COVID-19 and Its Vaccination in a High School Population","authors":"Mauricio Rodríguez-Álvarez ,&nbsp;Luis Pablo Cruz-Hervert ,&nbsp;María Eugenia Jiménez-Corona ,&nbsp;Norma Mongua-Rodríguez ,&nbsp;María Dolores Valle Martínez ,&nbsp;Benjamín Barajas Sánchez ,&nbsp;Javier Romero y Fuentes ,&nbsp;Lourdes García-García ,&nbsp;Samuel Ponce-de-León-Rosales","doi":"10.1016/j.arcmed.2025.103241","DOIUrl":"10.1016/j.arcmed.2025.103241","url":null,"abstract":"<div><h3>Background</h3><div>The coronavirus disease 2019 (COVID-19) pandemic had a profound impact on education in Mexico, with extended school closures and the shift to distance learning. The absence of an initial vaccine and the general need for evidence on prevention measures within university communities prompted this study.</div></div><div><h3>Objective</h3><div>To assess the knowledge, attitudes, and practices regarding COVID-19 and its vaccination in the high school community (HSC) of the National Autonomous University of Mexico (UNAM) by the third year of the pandemic.</div></div><div><h3>Methods</h3><div>A cross-sectional, 26-question online survey was conducted among UNAM HSC in September 2022. The data were analyzed using multivariate logistic and linear regression models to identify factors associated with vaccination.</div></div><div><h3>Results</h3><div>A total of 22,000 surveys were collected, 16,789 of which were eligible for analysis. Among these, 16,361 (97.4 %) respondents were vaccinated. The primary reason for nonvaccination was the inability to access a vaccine (37.2 %). Younger respondents (&lt;18 years) were more likely to be unvaccinated, 10–14 years, (OR: 5.36; 95 % CI: 2.12–13.55; <em>p</em> &lt; 0.001); and 15–18 years, (OR: 2.77; 95 % CI: 1.12–6.82, <em>p</em> = 0.028). Individuals with overweight/obesity (OR: 1.39; 95 % CI 1.05–1.85; <em>p</em> = 0.023); immunosuppression (OR: 2.6; 95 % CI: 1.56–4.33; <em>p</em> &lt; 0.001), and those who considered these conditions as risk factors for COVID-19 were significantly more likely to be unvaccinated. Conversely, those who viewed hypertension as a risk factor OR 0.7 (95 % CI 0.53–0.93)) or who were accustomed to face mask use OR 0.28 (95 % CI 0.22–0.35), <em>p</em> &lt; 0.001) were more likely to be vaccinated.</div></div><div><h3>Conclusions</h3><div>We found a high acceptance of COVID-19 vaccination at UNAM HSC, which may have contributed to the safer resumption of in-person activities and helped mitigate the impact of subsequent epidemic waves; the reasons for non-vaccination appear addressable through targeted logistical measures and tailored information.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 7","pages":"Article 103241"},"PeriodicalIF":4.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144154389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changing Landscape of Liver Cirrhosis Etiologies","authors":"Nahum Méndez-Sánchez ,&nbsp;Mariana M Ramírez-Mejía ,&nbsp;Ming-Hua Zheng ,&nbsp;Carlos Cortez-Hernández ,&nbsp;Elianee M Tovar-Bojorquez ,&nbsp;Raúl Contreras-Omaña ,&nbsp;Juan D Monsiváis-Morales ,&nbsp;Jacqueline Córdova-Gallardo ,&nbsp;Mauricio Castillo-Barradas ,&nbsp;Nubia Guzmán-Rodríguez ,&nbsp;María S González-Huezo ,&nbsp;Adrian Sandez-Araiza ,&nbsp;Eira Cerda-Reyes ,&nbsp;Stefanny Cornejo-Hernández ,&nbsp;Beatriz Barranco-Fragoso ,&nbsp;Ana D Cano-Contreras ,&nbsp;José M Remes-Troche ,&nbsp;Fatima Higuera-de-la-Tijera ,&nbsp;José L Pérez-Hernández ,&nbsp;Norberto Chávez-Tapia ,&nbsp;Heriberto Rodríguez-Hernández","doi":"10.1016/j.arcmed.2025.103240","DOIUrl":"10.1016/j.arcmed.2025.103240","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Liver cirrhosis is a major public health problem worldwide. In Mexico, the increased prevalence of obesity and type 2 diabetes mellitus (T2DM) has contributed to an increase in the prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD). This study examines the current etiologies of cirrhosis in Mexico, highlighting regional and demographic differences.</div></div><div><h3>Methods</h3><div>We conducted a multicenter cross-sectional study of 2182 patients with cirrhosis diagnosed between 2018 and 2024 in 13 tertiary care hospitals in northern, central, and southern Mexico. Demographic data, etiology, and complications were analyzed.</div></div><div><h3>Results</h3><div>MASLD was the most frequent cause of cirrhosis (42.8 %), followed by alcohol-related liver disease (ALD, 23.8 %) and hepatitis C virus (HCV, 12.2 %). MASLD was more common in older patients and women, while ALD was more frequent in younger patients and men. HCC was observed in 8.9 % of patients, with a higher prevalence in the central region. The most common complications were portal hypertension (59.5 %) and ascites (30.4 %). Regional differences were observed, with a higher prevalence of MASLD in central and southern Mexico, while ALD was more prominent in the northern region.</div></div><div><h3>Conclusion</h3><div>This cross-sectional study underscores the changing etiologies of liver cirrhosis in Mexico, with MASLD emerging as the leading cause, particularly in older patients and women. Regional differences were evident, with ALD being more frequent in younger patients and in men, especially in the northern region.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 7","pages":"Article 103240"},"PeriodicalIF":4.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144154388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to: “Clinical Characteristics and Outcomes of Infective Endocarditis in Patients With Cancer: A Multicenter Case-Control Study”","authors":"Gustavo Méndez-Hirata ,&nbsp;Frida Rivera-Buendía ,&nbsp;Eduardo Viveros-Rentería ,&nbsp;Eric Ochoa-Hein ,&nbsp;Patricia Cornejo-Juárez ,&nbsp;Manlio Márquez ,&nbsp;Jose Ramón Hidalgo-Dura ,&nbsp;Yoana Leyva-López ,&nbsp;Diana Vilar-Compte","doi":"10.1016/j.arcmed.2025.103233","DOIUrl":"10.1016/j.arcmed.2025.103233","url":null,"abstract":"","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 6","pages":"Article 103233"},"PeriodicalIF":4.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144116925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Declaration of Helsinki 2024: Advances and Persistent Setbacks From a Latin American and Caribbean Bioethical Perspective","authors":"Fernando Hellmann ,&nbsp;Susana M. Vidal ,&nbsp;Claude Vergès ,&nbsp;Constanza Ovalle ,&nbsp;Diego Fonti ,&nbsp;Gabriela Minaya ,&nbsp;Ignacio Maglio ,&nbsp;Luis Manuel López Dávila ,&nbsp;Maria Virginia Rodriguez Funes ,&nbsp;Marianela Barcia ,&nbsp;Martha Marcela Rodríguez Alanís ,&nbsp;Marta Ascura ,&nbsp;Thiago Rocha Da Cunha ,&nbsp;Xiomara Bu ,&nbsp;Volnei Garrafa ,&nbsp;José Ramón Acosta Sariego","doi":"10.1016/j.arcmed.2025.103237","DOIUrl":"10.1016/j.arcmed.2025.103237","url":null,"abstract":"","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 6","pages":"Article 103237"},"PeriodicalIF":4.7,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144106113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comprehensive Review of Behcet’s Disease Damage Assessment Tools","authors":"Alireza Khabbazi ,&nbsp;Ehsan Mehrtabar ,&nbsp;Saba Mehrtabar ,&nbsp;Amirreza Khalaji ,&nbsp;Aida Malek Mahdavi","doi":"10.1016/j.arcmed.2025.103238","DOIUrl":"10.1016/j.arcmed.2025.103238","url":null,"abstract":"<div><div>Outcome assessment of rheumatic diseases has a significant role in evaluating the effect of various therapies in clinical studies and in the treatment of these patients in daily practice. Outcome assessment in rheumatic disorders is based on the evaluation of disease activity, quality of life, disability, and mortality caused by the disease. Behçet’s disease (BD) is a multisystem inflammatory condition that can cause damage to multiple organs. Damage assessment, along with assessment of BD activity, are two necessary and complementary components of BD outcome measures, based on Outcome Measures in Rheumatology. In clinical trials of BD, outcome assessment has been based on disease activity measures, which do not measure damage severity. In this review, we considered three damage indices that have recently been introduced to assess BD-related injury, including vasculitis damage index (VDI), Behçet’s syndrome overall damage index (BODI), and Behçet’s disease damage index (BDI).</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 6","pages":"Article 103238"},"PeriodicalIF":4.7,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144106111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetes Mellitus Impairs the Bone Regeneration Capacity of Mesenchymal Stromal Cell-Based Therapy","authors":"Alann Thaffarell Portilho Souza ,&nbsp;Gileade Pereira Freitas ,&nbsp;Helena Bacha Lopes ,&nbsp;Denise Weffort ,&nbsp;Leticia Faustino Adolpho ,&nbsp;Maria Paula Oliveira Gomes ,&nbsp;Fabiola Singaretti Oliveira ,&nbsp;Adriana Luisa Gonçalves Almeida ,&nbsp;Marcio Mateus Beloti ,&nbsp;Adalberto Luiz Rosa","doi":"10.1016/j.arcmed.2025.103234","DOIUrl":"10.1016/j.arcmed.2025.103234","url":null,"abstract":"<div><h3>Background</h3><div>Diabetes mellitus (DM) negatively impacts bone tissue, leading to bone loss and increased fracture risk. Many individuals need additional treatments, and therapy based on mesenchymal stromal cells (MSCs) represents a promising treatment for bone defects in patients with diabetes.</div></div><div><h3>Aims</h3><div>The present study explored the effects of interactions between MSCs from normoglycemic (NG-MSCs) and diabetic (DM-MSCs) donors on osteoblast differentiation and the effects of cell therapy using NG-MSCs on bone regeneration in defects created in diabetic rats.</div></div><div><h3>Methods</h3><div>After inducing DM with streptozotocin, we evaluated the morphometric parameters of rat femurs and the osteoblast differentiation of MSCs, as well as the effects of the interaction between NG-MSCs and DM-MSCs on their osteoblast differentiation. The efficacy of cell therapy was measured by evaluating the bone repair in calvarial defects of diabetic rats treated with local injections of either NG-MSCs or a vehicle.</div></div><div><h3>Results</h3><div>DM induced bone loss and impaired the osteoblast differentiation of MSCs, which was partially restored by NG-MSCs, while the bone formation observed in defects treated with NG-MSCs and the vehicle was similar.</div></div><div><h3>Conclusion</h3><div>These results indicate that the beneficial effect of NG-MSCs on DM-MSCs did not translate into enhanced bone repair, mainly due to a hostile environment created by hyperglycemia, which compromised the ability of MSCs to induce bone formation.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 6","pages":"Article 103234"},"PeriodicalIF":4.7,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144106112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Clinical Characteristics and Outcomes of Infective Endocarditis in Patients With Cancer: A Multicenter Case-Control Study”","authors":"Hamidreza Zivarifar ,&nbsp;Ali Kamali ,&nbsp;Masoud Keikha","doi":"10.1016/j.arcmed.2025.103232","DOIUrl":"10.1016/j.arcmed.2025.103232","url":null,"abstract":"","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 6","pages":"Article 103232"},"PeriodicalIF":4.7,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144088841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Multimorbidity Burden in Frailty Transitions in Costa Rican Older Adults Using Multistate Markov Models","authors":"Rafael Ogaz-González ,&nbsp;Postmus D ,&nbsp;Ricardo Escamilla-Santiago ,&nbsp;Luis Miguel Gutiérrez-Robledo ,&nbsp;Malaquías López-Cervantes ,&nbsp;Eva Corpeleijn","doi":"10.1016/j.arcmed.2025.103230","DOIUrl":"10.1016/j.arcmed.2025.103230","url":null,"abstract":"<div><h3>Background and Aims</h3><div>The accumulation of non-communicable chronic diseases is recognized to play a crucial role in the deterioration of health in older adults, partly because it may impact frailty states. This study assessed the influence of multimorbidity on the phenotype transitions in frailty over time and frailty-related mortality risk.</div></div><div><h3>Methods</h3><div>Data from the Costa Rican Longevity and Healthy Aging Study Cohort (2005–2010) was used. A total of 2660 individuals aged 60 and above were included. Multimorbidity was defined as having three or more non-communicable diseases from 13 chronic conditions. Fried criteria were employed to assess frailty states (robust, pre-frail, frail). Markov-based multistate models were used to examine the impact of multimorbidity on frailty transitions and mortality over 5 years.</div></div><div><h3>Results</h3><div>Multimorbidity accelerates the transition to frailty. Compared to those with fewer than three non-communicable diseases, individuals with both multimorbidity and a prefrail state had a lower chance of recovering to robustness (HR:0.73 [95% CI: 0.54–0.99]), and a higher risk of becoming frail (HR:1.83 [95% CI: 1.43–2.34]). This translates into a 30-month earlier onset of frailty compared to individuals without chronic diseases. Multimorbidity increased the risk of all-cause mortality in those who were pre-frail (HR:1.83 [95% CI: 1.43–2.34]) but did not affect mortality risk in those who were already frail (HR:0.88 [95% CI: 0.62–1.23]).</div></div><div><h3>Conclusions</h3><div>Multimorbidity is a predictor for dynamic transitions to frailty or death. It favors the transition to “Frailty” more than to death and impacts mortality mostly in people with a “Pre-frail” state, encouraging them to explore opportunities for intervention.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 6","pages":"Article 103230"},"PeriodicalIF":4.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}