Archives of Medical Research最新文献

{"title":"Declaration of Helsinki 2024: Advances and Persistent Setbacks From a Latin American and Caribbean Bioethical Perspective","authors":"Fernando Hellmann , Susana M. Vidal , Claude Vergès , Constanza Ovalle , Diego Fonti , Gabriela Minaya , Ignacio Maglio , Luis Manuel López Dávila , Maria Virginia Rodriguez Funes , Marianela Barcia , Martha Marcela Rodríguez Alanís , Marta Ascura , Thiago Rocha Da Cunha , Xiomara Bu , Volnei Garrafa , José Ramón Acosta Sariego","doi":"10.1016/j.arcmed.2025.103237","DOIUrl":"10.1016/j.arcmed.2025.103237","url":null,"abstract":"","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 6","pages":"Article 103237"},"PeriodicalIF":4.7,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144106113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comprehensive Review of Behcet’s Disease Damage Assessment Tools","authors":"Alireza Khabbazi ,&nbsp;Ehsan Mehrtabar ,&nbsp;Saba Mehrtabar ,&nbsp;Amirreza Khalaji ,&nbsp;Aida Malek Mahdavi","doi":"10.1016/j.arcmed.2025.103238","DOIUrl":"10.1016/j.arcmed.2025.103238","url":null,"abstract":"<div><div>Outcome assessment of rheumatic diseases has a significant role in evaluating the effect of various therapies in clinical studies and in the treatment of these patients in daily practice. Outcome assessment in rheumatic disorders is based on the evaluation of disease activity, quality of life, disability, and mortality caused by the disease. Behçet’s disease (BD) is a multisystem inflammatory condition that can cause damage to multiple organs. Damage assessment, along with assessment of BD activity, are two necessary and complementary components of BD outcome measures, based on Outcome Measures in Rheumatology. In clinical trials of BD, outcome assessment has been based on disease activity measures, which do not measure damage severity. In this review, we considered three damage indices that have recently been introduced to assess BD-related injury, including vasculitis damage index (VDI), Behçet’s syndrome overall damage index (BODI), and Behçet’s disease damage index (BDI).</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 6","pages":"Article 103238"},"PeriodicalIF":4.7,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144106111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetes Mellitus Impairs the Bone Regeneration Capacity of Mesenchymal Stromal Cell-Based Therapy","authors":"Alann Thaffarell Portilho Souza ,&nbsp;Gileade Pereira Freitas ,&nbsp;Helena Bacha Lopes ,&nbsp;Denise Weffort ,&nbsp;Leticia Faustino Adolpho ,&nbsp;Maria Paula Oliveira Gomes ,&nbsp;Fabiola Singaretti Oliveira ,&nbsp;Adriana Luisa Gonçalves Almeida ,&nbsp;Marcio Mateus Beloti ,&nbsp;Adalberto Luiz Rosa","doi":"10.1016/j.arcmed.2025.103234","DOIUrl":"10.1016/j.arcmed.2025.103234","url":null,"abstract":"<div><h3>Background</h3><div>Diabetes mellitus (DM) negatively impacts bone tissue, leading to bone loss and increased fracture risk. Many individuals need additional treatments, and therapy based on mesenchymal stromal cells (MSCs) represents a promising treatment for bone defects in patients with diabetes.</div></div><div><h3>Aims</h3><div>The present study explored the effects of interactions between MSCs from normoglycemic (NG-MSCs) and diabetic (DM-MSCs) donors on osteoblast differentiation and the effects of cell therapy using NG-MSCs on bone regeneration in defects created in diabetic rats.</div></div><div><h3>Methods</h3><div>After inducing DM with streptozotocin, we evaluated the morphometric parameters of rat femurs and the osteoblast differentiation of MSCs, as well as the effects of the interaction between NG-MSCs and DM-MSCs on their osteoblast differentiation. The efficacy of cell therapy was measured by evaluating the bone repair in calvarial defects of diabetic rats treated with local injections of either NG-MSCs or a vehicle.</div></div><div><h3>Results</h3><div>DM induced bone loss and impaired the osteoblast differentiation of MSCs, which was partially restored by NG-MSCs, while the bone formation observed in defects treated with NG-MSCs and the vehicle was similar.</div></div><div><h3>Conclusion</h3><div>These results indicate that the beneficial effect of NG-MSCs on DM-MSCs did not translate into enhanced bone repair, mainly due to a hostile environment created by hyperglycemia, which compromised the ability of MSCs to induce bone formation.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 6","pages":"Article 103234"},"PeriodicalIF":4.7,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144106112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Clinical Characteristics and Outcomes of Infective Endocarditis in Patients With Cancer: A Multicenter Case-Control Study”","authors":"Hamidreza Zivarifar ,&nbsp;Ali Kamali ,&nbsp;Masoud Keikha","doi":"10.1016/j.arcmed.2025.103232","DOIUrl":"10.1016/j.arcmed.2025.103232","url":null,"abstract":"","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 6","pages":"Article 103232"},"PeriodicalIF":4.7,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144088841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Multimorbidity Burden in Frailty Transitions in Costa Rican Older Adults Using Multistate Markov Models","authors":"Rafael Ogaz-González ,&nbsp;Postmus D ,&nbsp;Ricardo Escamilla-Santiago ,&nbsp;Luis Miguel Gutiérrez-Robledo ,&nbsp;Malaquías López-Cervantes ,&nbsp;Eva Corpeleijn","doi":"10.1016/j.arcmed.2025.103230","DOIUrl":"10.1016/j.arcmed.2025.103230","url":null,"abstract":"<div><h3>Background and Aims</h3><div>The accumulation of non-communicable chronic diseases is recognized to play a crucial role in the deterioration of health in older adults, partly because it may impact frailty states. This study assessed the influence of multimorbidity on the phenotype transitions in frailty over time and frailty-related mortality risk.</div></div><div><h3>Methods</h3><div>Data from the Costa Rican Longevity and Healthy Aging Study Cohort (2005–2010) was used. A total of 2660 individuals aged 60 and above were included. Multimorbidity was defined as having three or more non-communicable diseases from 13 chronic conditions. Fried criteria were employed to assess frailty states (robust, pre-frail, frail). Markov-based multistate models were used to examine the impact of multimorbidity on frailty transitions and mortality over 5 years.</div></div><div><h3>Results</h3><div>Multimorbidity accelerates the transition to frailty. Compared to those with fewer than three non-communicable diseases, individuals with both multimorbidity and a prefrail state had a lower chance of recovering to robustness (HR:0.73 [95% CI: 0.54–0.99]), and a higher risk of becoming frail (HR:1.83 [95% CI: 1.43–2.34]). This translates into a 30-month earlier onset of frailty compared to individuals without chronic diseases. Multimorbidity increased the risk of all-cause mortality in those who were pre-frail (HR:1.83 [95% CI: 1.43–2.34]) but did not affect mortality risk in those who were already frail (HR:0.88 [95% CI: 0.62–1.23]).</div></div><div><h3>Conclusions</h3><div>Multimorbidity is a predictor for dynamic transitions to frailty or death. It favors the transition to “Frailty” more than to death and impacts mortality mostly in people with a “Pre-frail” state, encouraging them to explore opportunities for intervention.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 6","pages":"Article 103230"},"PeriodicalIF":4.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single Nucleotide Variants of the SLC2A9 Gene are Associated With Hyperuricemia in Mexican Patients With Type 2 Diabetes","authors":"Gloria Elizabeth Vázquez-Rivera ,&nbsp;Erika F. Gómez-García ,&nbsp;Renato Parra-Michel ,&nbsp;Rosalba Orozco-Sandoval ,&nbsp;Lourdes del Carmen Rizo-de la Torre ,&nbsp;Caridad A. Leal-Cortés ,&nbsp;Claudia Nayeli Contreras-Aceves ,&nbsp;Mariana Pérez-Coria ,&nbsp;Alfonso Farías-Basulto ,&nbsp;Francisco Mendoza-Carrera","doi":"10.1016/j.arcmed.2025.103235","DOIUrl":"10.1016/j.arcmed.2025.103235","url":null,"abstract":"<div><h3>Background</h3><div>Chronic kidney disease (CKD) due to diabetes is the third leading cause of death in Mexico. A relationship between high serum uric acid (SUA) levels and kidney disease have been demonstrated. On the other hand, variants of the <em>SLC2A9</em> gene have been associated with elevated SUA concentrations. This study evaluated the associations of the rs11722228, rs3775948, rs7678287, and rs1014290 variants with hyperuricemia and biochemical parameters in patients with type 2 diabetes (T2D).</div></div><div><h3>Methods</h3><div>The study included 1036 Mexican subjects with T2D. Patients were grouped based on the presence (<em>n</em> = 462) or absence (<em>n</em> = 574) of diabetic kidney disease (DKD). SUA concentrations and biochemical parameters were determined. Samples were genotyped through real-time polymerase chain reaction. Associations between genetic variants and hyperuricemia were analyzed by univariate and multivariate models adjusting for covariates.</div></div><div><h3>Results</h3><div>SUA levels and hyperuricemia prevalence were higher in the DKD group. rs3775948 and rs1014290 showed negative associations with hyperuricemia in the whole sample and in patients without DKD. rs7678287 was positively correlated with SUA and hyperuricemia in patients without DKD, whereas rs11722228 was a risk factor only in the DKD group. The presence of DKD and elevated triglycerides and total cholesterol were significant factors associated with hyperuricemia.</div></div><div><h3>Conclusions</h3><div>Variants rs3775948 and rs1014290 exhibit protective effects, while rs7678287 and rs11722228 may confer increased risk of hyperuricemia in Mexican patients with T2D. Analysis of <em>SLC2A9</em> gene variants could help in detecting patients at increased risk of kidney or cardiovascular complications due to hyperuricemia.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 6","pages":"Article 103235"},"PeriodicalIF":4.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143943417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human Voltage-Activated H+ Channel is Highly Expressed in Acute Myeloid Leukemia and is Associated With the Blast Differentiated Stage","authors":"Diego Issouribehere ,&nbsp;Nicolás Enrique ,&nbsp;Paulina Finochietto ,&nbsp;Juan Ignacio Felice ,&nbsp;Carolina Belli ,&nbsp;Clara Ventura ,&nbsp;Verónica Milesi","doi":"10.1016/j.arcmed.2025.103221","DOIUrl":"10.1016/j.arcmed.2025.103221","url":null,"abstract":"<div><h3>Background</h3><div>In acute myeloid leukemia (AML), hematopoietic precursors of myeloid cells proliferate rapidly but are arrested at an early stage, impeding their maturation and normal function. The human voltage-activated proton channel (hHv1) is a membrane protein with important roles in myeloid phagocytic cells. This work aimed to evaluate the expression of hHv1 channel as a novel biological marker associated with the process of cell differentiation in AML.</div></div><div><h3>Methods</h3><div>In this study, we evaluated the expression of the hHv1, at both mRNA and protein levels in AML.</div></div><div><h3>Results</h3><div>We demonstrated that the expression of hHv1 is upregulated at both mRNA and protein levels in AML. Moreover, our results indicate that hHv1 expression correlates with the degree of monocytic differentiation in AML cells in a pattern similar to that previously reported for NADPH oxidase (NOX2), a relevant cellular structure functionally coupled to the hHv1 channel. However, while increases in NOX2 components have not been associated with improved prognosis or survival, we found that the hHv1 upregulation was associated with better prognosis and survival outcomes.</div></div><div><h3>Conclusions</h3><div>These results suggest that hHv1 may serve as a novel biomarker for favorable prognosis in AML and may represent a promising therapeutic target.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 5","pages":"Article 103221"},"PeriodicalIF":4.7,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Balancing Priorities in Guideline Development: Consideration of Health Equity in WHO’s Normative Products on Obesity","authors":"Omar Dewidar ,&nbsp;Juan Pablo Peña-Rosas ,&nbsp;Jordi Pardo Pardo ,&nbsp;Vivian Welch ,&nbsp;Kevin Pottie ,&nbsp;Peter Tugwell","doi":"10.1016/j.arcmed.2025.103236","DOIUrl":"10.1016/j.arcmed.2025.103236","url":null,"abstract":"","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 7","pages":"Article 103236"},"PeriodicalIF":4.7,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143931366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to: Comorbidities and Sociodemographic Factors as Determinants of COVID-19 Outcome in Pregnant Women Hospitalized in Brazil","authors":"Francilene Maria Azevedo","doi":"10.1016/j.arcmed.2025.103229","DOIUrl":"10.1016/j.arcmed.2025.103229","url":null,"abstract":"","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 6","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143927640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial Metabolite Methylmalonic Acid, Subclinical Myocardial Injury, and its Incremental Predictive Value for Cardiovascular Mortality Risk","authors":"Fan Tang ,&nbsp;Miao Yan ,&nbsp;Zeng Wang ,&nbsp;Zhanchao Chen ,&nbsp;Yige Liu ,&nbsp;Mingyan E ,&nbsp;Shaohong Fang ,&nbsp;Yiying Zhang ,&nbsp;Shanjie Wang ,&nbsp;Bo Yu","doi":"10.1016/j.arcmed.2025.103226","DOIUrl":"10.1016/j.arcmed.2025.103226","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Methylmalonic acid (MMA) is involved in myocardial mitochondrial damage and energy metabolism disorders. We sought to investigate the association of MMA with subclinical myocardial injury and its incremental value in predicting cardiovascular mortality risk based on conventional risk factors and cardiac biomarkers.</div></div><div><h3>Methods</h3><div>This study included 11,373 participants aged ≥18 years without prevalent cardiovascular disease (CVD). The cross-sectional associations of MMA with subclinical elevation of cardiac biomarkers (high-sensitivity cardiac troponin [hs-cTn] and N-terminal pro-B-type natriuretic peptide [NT-proBNP]), and their prospective associations with long-term mortality, were assessed. The predictive performance for 10-year cardiovascular mortality was estimated.</div></div><div><h3>Results</h3><div>The association between MMA and elevated cardiac biomarkers was significant with a dose-response pattern. Compared with participants in the lowest quartile of MMA, the multivariable-adjusted rate ratios (95% CIs) in the highest quartile for elevated hs-cTnT and NT-proBNP were 2.35 (1.64–3.37) and 1.35 (1.12–1.62), respectively (each <em>p</em> trend &lt;0.001). Strikingly, the cardiovascular mortality risk associated with elevated hs‐cTnT or NT‐proBNP was at least two-fold higher in adults with elevated MMA levels than in those with lower MMA levels. The adjusted hazard ratios (95% CIs) of elevated hs‐cTnT for cardiovascular mortality were 1.58 (1.00–2.50) among individuals with MMA ≤125 nmol/L and 2.45 (1.94–3.11) among participants with MMA &gt;125 nmol/L.</div></div><div><h3>Conclusion</h3><div>MMA accumulation is independently associated with subclinical myocardial injury before cardiovascular events occur. These findings support the additional value of mitochondria-related indicators to guide cardiac biomarker-based screening of populations at high risk for cardiovascular events.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 6","pages":"Article 103226"},"PeriodicalIF":4.7,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143922066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}