Archives of Medical Research最新文献

{"title":"Mutational Profiling of Korean Lymphomas and Diffuse Large B-Cell Lymphoma Subtype Classification Using Targeted Panel Sequencing","authors":"Gilsung Yoo ,&nbsp;Jooyoung Cho ,&nbsp;Hyeong Ju Kwon ,&nbsp;Taesic Lee ,&nbsp;JinJu Kim ,&nbsp;Juwon Kim","doi":"10.1016/j.arcmed.2024.103158","DOIUrl":"10.1016/j.arcmed.2024.103158","url":null,"abstract":"<div><h3>Background</h3><div>Lymphoma is a common hematological malignancy with diverse morphological and immunophenotypic characteristics that may affect treatment and outcomes. Thus, accurate differential diagnosis is crucial, and molecular genetic testing is valuable. We aimed to investigate the genetic characteristics of Korean patients with lymphoma using a next-generation sequencing (NGS)-based targeted panel.</div></div><div><h3>Methods</h3><div>We designed a panel covering 588 genes clinically and diagnostically relevant in lymphoma through a literature review and performed targeted panel sequencing of 34 formalin-fixed paraffin-embedded samples from patients with lymphoma.</div></div><div><h3>Results</h3><div>Among the 34 samples examined, diffuse large B-cell lymphoma (DLBCL) was the most common, followed by NK/T-cell lymphoma, peripheral T-cell lymphoma, anaplastic large cell lymphoma, T-lymphoblastic leukemia/lymphoma, MALT lymphoma, and mantle cell lymphoma. The genes <em>TP53, MYD88, CD79B, FOXO1, KMT2D, MYD88, TNFRSF14</em>, and <em>TET2</em> had the highest number of mutations. For patients with DLBCL, we used modified genetic subtype classification algorithms from previous studies and successfully classified 31.3–50 % of them into specific subtypes. Notably, four patients were allocated a distinct subtype across all algorithms.</div></div><div><h3>Conclusions</h3><div>Our targeted panel sequencing can effectively reveal lymphoma mutational profiles of samples in clinical settings and partially outline the mutational landscape of lymphomas in the Korean population, particularly DLBCL.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 4","pages":"Article 103158"},"PeriodicalIF":4.7,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143178832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Humoral immune response to SARS-CoV-2 vaccines in patients with autoimmune rheumatic diseases","authors":"Paula María Corbalan ,&nbsp;Rodrigo Hernán Tomas-Grau ,&nbsp;Mariana Pera ,&nbsp;Diego Ploper ,&nbsp;Gabriela Vanesa Espasa ,&nbsp;Silvia Inés Cazorla ,&nbsp;María Lilia Leguizamón ,&nbsp;Esteban Vera Pingitore ,&nbsp;Ana Lucía Barbaglia ,&nbsp;Carolina Maldonado-Galdeano ,&nbsp;María Constanza Bertolaccini ,&nbsp;Silvana Estefanía Soliz-Santander ,&nbsp;Luciana González Lucero ,&nbsp;César Luis Ávila ,&nbsp;Rosana Nieves Chehín ,&nbsp;Héctor Raúl Sueldo ,&nbsp;Sergio Benjamín Socias ,&nbsp;Verónica Inés Bellomio","doi":"10.1016/j.arcmed.2024.103141","DOIUrl":"10.1016/j.arcmed.2024.103141","url":null,"abstract":"<div><h3>Background</h3><div>Patients with autoimmune rheumatic diseases (ARD) are at increased risk of infection due to their impaired immune response, which also reduces vaccination efficacy. Although several studies have evaluated the serological response to SARS-CoV-2 mRNA-based vaccines in patients with ARD, limited information on immune responses to other vaccination platforms is available.</div></div><div><h3>Aims</h3><div>This observational prospective study aims to investigate the humoral immune response to different SARS-CoV-2 vaccines in patients with ARD.</div></div><div><h3>Methods</h3><div>Total 66 patients with ARD who were scheduled to receive any SARS-CoV-2 vaccine (Gam-COVID-Vac; AZD1222; BBIBP-CorV; mRNA-1273; BNT162b2 and Ad5-nCoV) were enrolled in the study. We analyzed the humoral immune response elicited against the spike receptor-binding-domain (RBD) of SARS-CoV-2 at 0 and 14 ± 2 d after the first vaccine dose and at 0 ± 1, 21–45, and 180 d after the second one. Titers were also measured in patients who received an additional dose of vaccine.</div></div><div><h3>Results</h3><div>After the second dose of the vaccine, 70.5 % experienced seroconversion. The type of vaccine affected serological responses. BBIBP-CorV resulted in lower seroconversion rates, while mixed vaccinations increased anti-RBD titers. Other factors impacting seroconversion were higher prednisone doses, biological therapy, and hypertension. Patients treated with Rituximab had the lowest seroconversion rate. Regression analysis revealed an 89.0 % lower probability of seroconversion for BBIBP-CorV recipients and an 88.0 % lower probability for those with hypertension. An additional dose increased seroconversion to 85.7 %.</div></div><div><h3>Conclusions</h3><div>Two-dose vaccination schemes exhibited a 70.5 % seroconversion rate to the SARS-CoV-2 vaccine. An additional dose increased this rate to 85.0 %. Reduced humoral immune responses were associated with BBIBP-CorV, prednisone higher doses, and biological therapy.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 3","pages":"Article 103141"},"PeriodicalIF":4.7,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143173320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of 5 G mobile phone network electromagnetic field exposure on testicular endoplasmic reticulum stress and the protective role of coenzyme Q10","authors":"Hamit Yilmaz ,&nbsp;Levent Tümkaya ,&nbsp;Tolga Mercantepe ,&nbsp;Adnan Yılmaz ,&nbsp;Fatih Gül ,&nbsp;Zehra Topal Suzan","doi":"10.1016/j.arcmed.2024.103157","DOIUrl":"10.1016/j.arcmed.2024.103157","url":null,"abstract":"<div><h3>Aim</h3><div>Nowadays, the electromagnetic field (EMF) has become an issue of <em>electromagnetic pollution</em>. This study aimed to determine the effect of 5 G Fr1 frequency band EMF waves on endoplasmic reticulum (ER) stress in testicular tissue and to demonstrate the efficacy of coenzyme Q10 (CoQ10) in suppressing the potential situation.</div></div><div><h3>Materials and Methods</h3><div>Three groups of eight male Sprague-Dawley rats were established. In group I (control) received only saline solution by oral gavage. In group II (EMF), saline solution was administered by oral gavage and the rats were exposed to 5.9 GHz EMF for 2 h/d (09:00–11:00). In group III (EMF+ CoQ10), the EMF exposure was created in the same way as in group II and CoQ10 was given daily at 10 mg/kg (CoQ10), 2 mg/kg dissolved in corn oil and administered by oral gavage for the experimental period (30 days).</div></div><div><h3>Results</h3><div>Histopathological damage, including edematous regions, vascular congestion, and neutrophil inflammation accompanied by loss of spermatogenic cells, particularly spermatozoa, and spermatids, increased thiobarbituric acid (TBARS) and decreased total thiol (TT) levels were observed in the seminiferous tubules in the EMF group. Furthermore, germinal epithelial cells showing intense GRP-78 immunopositivity and spermatogenic cells indicating C/EBP homologous protein (CHOP) immunopositivity were increased in the seminiferous tubules. On the other hand, in the EMF+CoQ10 group, both histopathological and biochemical findings were observed in the opposite direction.</div></div><div><h3>Conclusion</h3><div>Due to its antioxidant properties and its ability to suppress oxidative stress and apoptosis, CoQ10 may be a promising candidate against 5 G EMF-induced testicular ER damage.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 4","pages":"Article 103157"},"PeriodicalIF":4.7,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143179117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reviewers list","authors":"","doi":"10.1016/S0188-4409(24)00220-0","DOIUrl":"10.1016/S0188-4409(24)00220-0","url":null,"abstract":"","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 1","pages":"Article 103170"},"PeriodicalIF":4.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143159715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"You Are as Old as the Connectivity You Keep: Distinct Neurophysiological Mechanisms Underlying Age-Related Changes in Hand Dexterity and Strength","authors":"Emilio Chiappini ,&nbsp;Sonia Turrini ,&nbsp;Francesca Fiori ,&nbsp;Mariagrazia Benassi ,&nbsp;Alessia Tessari ,&nbsp;Giuseppe di Pellegrino ,&nbsp;Alessio Avenanti","doi":"10.1016/j.arcmed.2024.103031","DOIUrl":"10.1016/j.arcmed.2024.103031","url":null,"abstract":"<div><h3>Background</h3><div>Aging can lead to a decline in motor control. While age-related motor impairments have been documented, the underlying changes in cortico-cortical interactions remain poorly understood.</div></div><div><h3>Methods</h3><div>We took advantage of the high temporal resolution of dual-site transcranial magnetic stimulation (dsTMS) to investigate how communication between higher-order rostral premotor regions and the primary motor cortex (M1) influences motor control in young and elderly adults. We assessed the dynamics of connectivity from the inferior frontal gyrus (IFG) or pre-supplementary motor area (preSMA) to M1, by testing how conditioning of the IFG/preSMA affected the amplitude of motor evoked potentials (MEPs) induced by M1 stimulation at different temporal intervals. Moreover, we explored how age-related changes in premotor-M1 interactions relate to motor performance.</div></div><div><h3>Results</h3><div>Our results show that both young and elderly adults had excitatory IFG-M1 and preSMA-M1 interactions, but the two groups’ timing and strength differed. In young adults, IFG-M1 interactions were early and time-specific (8 ms), whereas in older individuals, they were delayed and more prolonged (12-16 ms). PreSMA-M1 interactions emerged early (6 ms) and peaked at 10-12 ms in young individuals but were attenuated in older individuals. Critically, a connectivity profile of the IFG-M1 circuit like that of the young cohort predicted better dexterity in older individuals, while preserved preSMA-M1 interactions predicted greater strength, suggesting that age-related motor decline is associated with specific changes in premotor-motor networks.</div></div><div><h3>Conclusions</h3><div>Preserving youthful motor network connectivity in older individuals is related to maintaining motor performance and providing information for interventions targeting aging effects on behavior.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 1","pages":"Article 103031"},"PeriodicalIF":4.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Respiratory pathogen trends in queensland, australia between 2018 and 2021: A statewide cohort study before and after the initial COVID-19 outbreak","authors":"Amy L. Sweeny ,&nbsp;John Gerrard ,&nbsp;Kylie Alcorn ,&nbsp;Gary Grant ,&nbsp;Ya-Ling Huang ,&nbsp;Benjamin Gerhardy ,&nbsp;Gerben Keijzers ,&nbsp;COVERED-COVID study research investigators","doi":"10.1016/j.arcmed.2024.103144","DOIUrl":"10.1016/j.arcmed.2024.103144","url":null,"abstract":"<div><h3>Background</h3><div>The SARS-CoV-2 pandemic and accompanying public health measures disrupted the normal transmission of respiratory viral pathogens. Less is known about the effects on bacterial pathogens.</div></div><div><h3>Aims</h3><div>To assess the impact of public health restrictions on common respiratory pathogens (influenza viruses, respiratory syncytial virus (RSV) and the following bacterial pathogens: <em>Streptococcus pneumoniae (S. pneumoniae), Klebsiella pneumoniae (K. pneumoniae), Pseudomonas aeruginosa (P. aeruginosa)</em> and <em>Staphylococcus aureus (S. aureus)</em>.</div></div><div><h3>Methods</h3><div>This statewide cohort study used respiratory specimen result data from 237 health facilities in Queensland, Australia, collected between January 2018 and June 2021. Trends and weekly positive rates per 100 tests/cultures for weeks 11–27 (with 95% confidence intervals) were compared between pre-pandemic (2018/2019), early pandemic restrictions (2020), and easing of restrictions (2021) periods.</div></div><div><h3>Results</h3><div>Over 260,000 viral PCRs and 180,000 cultures were analyzed. Decreases in influenza and RSV were observed in 2020 from 10.8 to 1.1 and 9.5 to 2.5 per 100 tests, respectively; <em>S. pneumoniae</em> decreased from 1.7 to 1.1 per 100 cultures. Influenza levels remained low until the end of the study period. There was no change in the detection of <em>S. aureus</em> or <em>P. aeruginosa</em> per 100 cultures, but cultures positive for <em>K. pneumoniae</em> increased from 1.2 in 2018/2019 to 1.8 in 2020 and 1.6 in 2021. After restrictions eased, RSV rates increased to levels higher than before the pandemic.</div></div><div><h3>Conclusions</h3><div>Transmission of droplet-spread pathogens decreased after the introduction of public health restrictions due to the COVID-19 pandemic<em>.</em> The increase in <em>K. pneumoniae</em>, often associated with nosocomial infections, warrants further investigation.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 3","pages":"Article 103144"},"PeriodicalIF":4.7,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Membrane vesicles from lactobacillus acidophilus reduce intestinal inflammation and increase 5-HT in the substantia nigra of rats with parkinson's disease","authors":"Khadijeh Sheikh,&nbsp;Javad Arasteh,&nbsp;Maryam Tajabadi Ebrahimi,&nbsp;Ardeshir Hesampour","doi":"10.1016/j.arcmed.2024.103143","DOIUrl":"10.1016/j.arcmed.2024.103143","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to investigate the role of membrane vesicles (MVs) from the probiotic Lactobacillus acidophilus in reducing intestinal inflammation and increasing 5-hydroxytryptamine (5-HT) and tyrosine hydroxylase (TH) in the substantia nigra in the 6-hydroxydopamine (6-OHDA) rat model of Parkinson's disease (PD).</div></div><div><h3>Methods</h3><div>Twenty healthy male Wistar rats were randomly assigned to four groups (<em>n</em> = 5 per group), including a) control, b) 6-OHDA, c) 6-OHDA+MV, and d) sham groups. PD was induced by bilateral injection of 6-OHDA. Rats in the 6-OHDA+MV group received MV equivalent to 1 × 10⁷ colony-forming units (CFU)/mL 3 d/wk by oral gavage for 4 wk. At the end of 4 wk, all rats were sacrificed; the brain and small intestine were removed for cellular and molecular analysis.</div></div><div><h3>Results</h3><div>The induction of PD by 6-OHDA induced a remarkable decrease in beam-walking (<em>p</em> &lt; 0.0001). In addition, the expression of protein and genes (receptor) of 5-HT (r-5-HT1A) decreased, and that of protein and gene (receptor; GABBR1) of GABA increased in the PD group <em>(p</em> &lt; 0.05 compared with the healthy control group), while MV gavage of 6-OHDA-injected rats controlled these factors in the substantia nigra. In the intestinal tissue, the expression of TLR-4 and α-synuclein gene was significantly increased in the 6-OHDA group compared to the control group (<em>p</em> &lt; 0.0001).</div></div><div><h3>Conclusion</h3><div>MVs might act as potential beneficial tools to reduce intestinal inflammation, control neurological damage associated with PD, and increase 5-HT neurotransmitters. It seems that MVs from L. acidophilus may have therapeutic potential in Parkinson's neurological disorder by controlling the gut-brain axis.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 3","pages":"Article 103143"},"PeriodicalIF":4.7,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PAM-13 in clinical cancer care: A systematic review","authors":"Kenzy Jean Pierre ,&nbsp;Elise Verot ,&nbsp;Wafa Bouleftour","doi":"10.1016/j.arcmed.2024.103145","DOIUrl":"10.1016/j.arcmed.2024.103145","url":null,"abstract":"<div><h3>Background</h3><div>The Patient Activation Measure-13 (PAM-13) assesses patients’ ability to manage their healthcare. This systematic review aimed to summarize the relationship between the PAM-13 and patient characteristics, as well as program effectiveness.</div></div><div><h3>Methods</h3><div>A systematic literature search was conducted using the PubMed database and following the PRISMA guidelines. After screening and selection processes, a total of 21 articles were included for analysis.</div></div><div><h3>Results</h3><div>Half of single cancer type studies have been conducted on breast cancer. In terms of impact on the PAM-13 score, non-digital programs (75%) demonstrated higher efficacy in cancer care compared to digital ones (14.29%). Patient characteristics, including education, fear of recurrence, and time spent with healthcare providers, influenced activation levels.</div></div><div><h3>Conclusion</h3><div>This systematic review provides insights into the association of PAM-13 with patient characteristics and program effectiveness in clinical cancer care. Future research should validate interventions using PAM-13 and improve digital initiatives to optimize cancer care outcomes.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 3","pages":"Article 103145"},"PeriodicalIF":4.7,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Throughput RNA Sequencing of Peripheral Blood Mononuclear Cells Reveals Inflammatory State in Women with PCOS","authors":"Roozbeh Heidarzadehpilehrood ,&nbsp;Maryam Pirhoushiaran ,&nbsp;Malina Binti Osman ,&nbsp;King-Hwa Ling ,&nbsp;Habibah Abdul Hamid","doi":"10.1016/j.arcmed.2024.103129","DOIUrl":"10.1016/j.arcmed.2024.103129","url":null,"abstract":"<div><h3>Background</h3><div>Polycystic ovary syndrome (PCOS) is an endocrine and reproductive condition affecting women of reproductive age, although its expression profiles and molecular pathways are not fully understood.</div></div><div><h3>Aims</h3><div>To identify the transcriptome expression profiles of peripheral blood mononuclear cells (PBMCs) in women with PCOS and controls. To investigate noninvasive diagnostic biomarkers and potential treatment targets to improve women's fertility.</div></div><div><h3>Methods</h3><div>RNA sequencing (RNA-Seq) was conducted on PBMC samples from six patients with PCOS and six healthy controls. qRT-PCR validation was carried out in 68 subjects. Multivariate logistic regression was performed to assess the combined impact of biomarkers.</div></div><div><h3>Results</h3><div>A total of 186 differentially expressed genes (DEG) were found between patients and controls (log₂FC &gt;1, <em>p</em> &lt; 0.05). Enrichment analysis revealed cytokine-mediated signaling pathways, cytokine activity, and cytokine-cytokine receptor interaction. RNA sequencing showed consistency with qRT-PCR. Women with PCOS had significantly higher levels of <em>AQP9</em> (<em>p</em> &lt; 0.001), <em>PROK2</em> (<em>p</em> = 0.001), and <em>S100A12</em> (<em>p</em> &lt; 0.001) expression compared to controls. <em>AQP9</em> (AUC = 0.77), <em>PROK2</em> (AUC = 0.71), and <em>S100A12</em> (AUC = 0.82) adequately discriminated women with PCOS from healthy controls. In addition, multiple logistic regression on biomarkers resulted in a significant diagnostic power with an AUC = 0.89, 95 % CI: 0.81–0.97, <em>p</em> &lt; 0.0001. Further associations were analyzed between relative gene expression and clinical, anthropometric, hormonal, and ultrasonographic data.</div></div><div><h3>Conclusions</h3><div>Dysregulated RNA expression in PBMCs may contribute to an increased risk of PCOS and serve as a potential diagnostic biomarker. The involvement of inflammatory and cytokine-related pathways supports the notion that PCOS is a chronic inflammatory condition.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 3","pages":"Article 103129"},"PeriodicalIF":4.7,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142796734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preface Updating reproductive medicine","authors":"Victor S. Vital-Reyes ,&nbsp;J. Ricardo Loret De Mola","doi":"10.1016/j.arcmed.2024.103135","DOIUrl":"10.1016/j.arcmed.2024.103135","url":null,"abstract":"","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"55 8","pages":"Article 103135"},"PeriodicalIF":4.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}