Archives of Medical Research最新文献

{"title":"A Pattern of Increased Aggressiveness for Colorectal Cancer in Northern Mexico: A Multicenter Retrospective Cohort From 2018 to 2023","authors":"Raymundo A. Muñoz Cabello ,&nbsp;Luis A. Hernández Flores ,&nbsp;Alfonzo E. Muñoz Cabello ,&nbsp;Salvador Pizarro Chávez","doi":"10.1016/j.arcmed.2025.103285","DOIUrl":"10.1016/j.arcmed.2025.103285","url":null,"abstract":"<div><h3>Background</h3><div>Colorectal cancer (CRC) is the third most prevalent cancer worldwide and the second leading cause of cancer-related deaths. Early-onset CRC is often more aggressive and is on the rise. In Mexico, 16,082 cases were diagnosed in 2022; however, epidemiological data remain limited—especially in northern regions where red meat consumption is high and screening adherence is low. This study aims to identify regional CRC trends in Chihuahua, a northeastern Mexican state.</div></div><div><h3>Methods</h3><div>A retrospective cohort study of CRC cases from 2018 to 2023 was conducted at two centers in Chihuahua City. Data on demographics, tumor location, stage, and genetic testing (KRAS, NRAS, and BRAF) were obtained from medical and pathology records. Analysis included descriptive statistics, <em>t</em>-tests and χ² tests (<em>p</em>≤0.05), and a moving average analysis to assess annual trends.</div></div><div><h3>Results</h3><div>Among 451 CRC cases, the mean age was 60 ± 12 years and 57.8% were male. Two-thirds presented with advanced-stage disease (III/IV). Patients ≤49 years showed a high prevalence of proximal tumors and advanced-stage diagnoses, especially stage IVc. Over half of metastatic cases lacked genetic analysis. There was a <em>U</em>-shaped trend among age groups, with patients under 50 and over 70 being diagnosed at higher clinical stages (<em>p</em>=0.6).</div></div><div><h3>Conclusions</h3><div>The high proportion of advanced-stage CRC in patients under 50, combined with the lack of genetic testing, highlights two key issues in our region: aggressive disease and limited access to adequate care. These findings underscore the need for targeted research and improved public health strategies in high-risk areas such as northern Mexico.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"57 1","pages":"Article 103285"},"PeriodicalIF":3.4,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144902203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethical considerations in the use of add-ons in assisted reproductive technologies","authors":"Rocío Núñez Calonge ,&nbsp;Rafael Trinchant ,&nbsp;Josep Santaló ,&nbsp;Fernando Abellán ,&nbsp;Lydia Feito ,&nbsp;Alfonso De La Fuente ,&nbsp;Javier Marqueta ,&nbsp;Montserrat Roca ,&nbsp;Marina Martinez ,&nbsp;Elisa Salo ,&nbsp;Ignacio Arnott ,&nbsp;Víctor Saul Vital Reyes","doi":"10.1016/j.arcmed.2025.103287","DOIUrl":"10.1016/j.arcmed.2025.103287","url":null,"abstract":"","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"57 1","pages":"Article 103287"},"PeriodicalIF":3.4,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144902338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanism of SENP1-Mediated Regulation of Liver Sinusoidal Endothelial Cells to Promote Regeneration Via the HIF-1α Signaling Pathway","authors":"Zhe Qing ,&nbsp;Jian Duan ,&nbsp;Qun Luo ,&nbsp;Jinlan He ,&nbsp;Hanfei Huang ,&nbsp;Zhong Zeng","doi":"10.1016/j.arcmed.2025.103295","DOIUrl":"10.1016/j.arcmed.2025.103295","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Liver sinusoidal endothelial cells (LSECs) play a critical role in liver regeneration, but the specific molecular mechanism underlying this process remains unclear. Previous studies have shown that Sentrin/SUMO-specific protease 1 (SENP1) maintains the differentiation state of LSECs and promotes their proliferation under hypoxic conditions; however, the role of SENP1 in promoting liver regeneration by regulating LSECs is still unknown.</div></div><div><h3>Methods</h3><div>We employed a 70% hepatectomy (PHx) mouse model to explore the molecular mechanism underlying SENP1 regulation of LSECs and to observe the promotion of liver regeneration via the HIF-1α signaling pathway <em>in vitro</em> and <em>in vivo.</em></div></div><div><h3>Results</h3><div>First, we found that the liver regeneration began on the first day after hepatectomy, while SENP1 expression in liver tissue was significantly upregulated. After SENP1 downregulation, the expression of Ki-67 and von Willebrand factor (vWF) in liver tissue decreased, as did the rate of liver regeneration. Second, <em>in vitro</em>, the proliferation activity of LSECs with SENP1 overexpression increased, and fenestration was better maintained. After co-culturing hepatocytes with LSECs that overexpress SENP1, an EdU assay showed that hepatocyte proliferation ability increased significantly. However, the opposite occurred when either a SENP1 or a HIF-1α inhibitor was used. <em>In vivo</em>, we observed that SENP1 can activate the VEGF/VEGFR2/Id1 signaling axis, upregulating the expression of VEGF and HGF through the HIF-1α signaling pathway, thus promoting hepatocyte proliferation and angiogenesis.</div></div><div><h3>Conclusions</h3><div>SENP1 may promote liver regeneration by regulating LSECs dependent on the HIF-1α signaling pathway.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 8","pages":"Article 103295"},"PeriodicalIF":3.4,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144887245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biochemical Profile of Recovered Individuals With Mild COVID-19: A Cross-Sectional View at Two Different Time Points","authors":"Uzair Abbas ,&nbsp;Ishfaque Ahmed ,&nbsp;Muhib Ullah Khalid ,&nbsp;Sumbal Hafeez ,&nbsp;Sawairah Mukhtiar ,&nbsp;Niaz Hussain ,&nbsp;Maryam Nasrumminallah ,&nbsp;Muhammad Shahid Khan ,&nbsp;Nisha Babar ,&nbsp;Shizrah Ashraf ,&nbsp;Pershad Kumar","doi":"10.1016/j.arcmed.2025.103286","DOIUrl":"10.1016/j.arcmed.2025.103286","url":null,"abstract":"<div><h3>Aim</h3><div>This study was designed to cross–sectionally evaluate the frequency of long COVID-19, along with their hematological and biochemical parameters in survivors of mild COVID-19 after 6–15 months of acute infection.</div></div><div><h3>Methods</h3><div>We recruited 75 age-matched healthy controls (HC) and 150 individuals who had recovered from mild cases of COVID-19. The recovered individuals were grouped according to the time elapsed since acute infection: 6–10 month (CoV_A) and &gt;10–15 month of recovery (CoV_B). A brief clinical history was taken and detailed hematological and biochemical blood parameters were measured.</div></div><div><h3>Results</h3><div>In our study, 64% of individuals had symptoms of long COVID. There were differential symptoms and presenting complaints associated with time since acute infection. The recovered group had significantly different hemoglobin concentration, red blood cell (RBC) count, white blood cell (WBC) count, lymphocyte, interleukin-6 (IL-6), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and vitamin D3 levels, compared with the healthy controls (<em>p</em>&lt;0.05). Differences were also found between the 6-10 months and the &gt;10–15 month recovery groups (<em>p</em>&lt;0.05).</div></div><div><h3>Conclusion</h3><div>Differential biochemical markers related to the time elapsed since acute infection show a different metabolic and biochemical status of the host at different time points after infection. Moreover, the pathophysiological pathways involved in these dysregulated biochemical markers should also be studied in relation to the long term impact of COVID-19 infection.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"57 1","pages":"Article 103286"},"PeriodicalIF":3.4,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144866485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"rs.11196205 Variant in the TCF7L2 Gene is Associated With an Increased Cardiovascular Risk in Individuals With Hypertension and Diabetes","authors":"Lívia da Cunha Agostini ,&nbsp;Letícia Fernandes Dias Coelho ,&nbsp;Renata Bárbara Machado e Silva ,&nbsp;Nayara Nascimento Toledo Silva ,&nbsp;Ana Cláudia Faria Lopes ,&nbsp;Vanessa de Almeida Belo ,&nbsp;Wendel Coura-Vital ,&nbsp;Luiz Fernando de Medeiros Teixeira ,&nbsp;Angélica Alves Lima ,&nbsp;Glenda Nicioli da Silva","doi":"10.1016/j.arcmed.2025.103268","DOIUrl":"10.1016/j.arcmed.2025.103268","url":null,"abstract":"<div><h3>Background and Aims</h3><div>The interaction between genetic polymorphisms and environmental factors increases the risk of developing a diabetic phenotype which is associated with systemic arterial hypertension (SAH) and cardiovascular diseases. Variants in the T-cell factor 7-like 2 (<em>TCF7L2</em>) gene have been associated with type 2 diabetes mellitus (T2DM). To investigate the association of the rs.11196205 polymorphism of the <em>TCF7L2</em> gene with biochemical and anthropometric parameters and cardiovascular risk indices in Brazilian patients with SAH and T2DM.</div></div><div><h3>Methods</h3><div>The polymorphism was identified by qPCR in 664 samples from four groups: Control (CG-without diabetes or hypertension), diabetic (DG-normotensive), hypertensive (HG-without diabetes) and hypertensive diabetic (HDG), using the TaqMan® system. Biochemical dosages were taken for the lipid profile: triglycerides (TG), total cholesterol, HDL, LDL, and uric acid. Anthropometric measurements were taken for body mass index (BMI), visceral fat index and cardiovascular risk calculations, including the atherogenic index of plasma (AIP), visceral adiposity index (VAI), triglyceride-glucose (TyG) index and uric acid/HDL-c ratio (UA/HDL). Bivariate logistic regression was used to identify variables associated with SAH and T2DM. Subsequent categorical variables were analyzed using multinomial logistic regression.</div></div><div><h3>Results</h3><div>The GG genotype of the rs.11196205 variant of the <em>TCF7L2</em> gene was associated with an increased risk of hypertension and diabetic hypertension. Patients in the GHD group with the GG genotype showed worsening BMI parameters and TyG index values.</div></div><div><h3>Conclusion</h3><div>The GG genotype of the rs.11196205 variant of the <em>TCF7L2</em> gene acts as a cardiovascular risk genotype in patients with diabetic hypertension.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"57 1","pages":"Article 103268"},"PeriodicalIF":3.4,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144866486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma Serotonin as a Biomarker of the Severity of Attention Deficit Hyperactivity Disorder, in Children and Overweight/Obesity","authors":"Gabriel Manjarrez-Gutiérrez ,&nbsp;Martha Cristina Fernández-Cruz ,&nbsp;Chiharu Murata ,&nbsp;Teresa Neri-Gómez","doi":"10.1016/j.arcmed.2025.103259","DOIUrl":"10.1016/j.arcmed.2025.103259","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Recently, the potential use of plasma serotonin concentration as a biomarker for various diseases has been reported. However, whether plasma serotonin levels are useful for diagnosing attention deficit hyperactivity disorder (ADHD) remains controversial. To evaluate 5-hydroxytryptamine (5-HT, serotonin) as a biomarker for ADHD diagnosis, its severity, and overweight/obesity in school-aged children.</div></div><div><h3>Methods</h3><div>Eighty-nine school-aged children (20 controls and 69 with ADHD: 17 hyperactive, 26 inattentive, and 26 mixed) were analyzed. Free 5-HT (5-HT_F) and platelet 5-HT (5-HT_P) levels were compared for ADHD presence, severity, and obesity, respectively, using the Kruskal-Wallis test. Multiple regression models assessed the predictive value of 5-HT_F and 5-HT_P for the presence and severity of ADHD, adjusting for age and obesity. The diagnostic utility of 5-HT_F was evaluated using odds ratios (OR) and area under the curve (AUC) from logistic regression.</div></div><div><h3>Results</h3><div>Patients with ADHD exhibited significantly elevated 5-HT_F levels. No significant subgroup differences were found, but 5-HT_F levels increased with ADHD severity. Higher 5-HT_F levels were also observed in patients with overweight/obesity. Inverse trends were noted for 5-HT_P, though less pronounced. Logistic regression showed a 71 % increase in ADHD odds for each 0.1 µmol/L rise in 5-HT_F. ORs for ADHD severity were 8.77 (severe), 2.31 (moderate), and 0.45 (mild). The AUC for 5-HT_F was 0.76 for ADHD diagnosis and 0.93 for moderate/severe ADHD.</div></div><div><h3>Conclusions</h3><div>Plasma 5-HT_F concentration can be a useful biomarker for the ADHD diagnosis, its severity, and comorbidity with overweight/obesity in these patients.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"57 1","pages":"Article 103259"},"PeriodicalIF":3.4,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144866487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Projections of the Burden of Rheumatoid Arthritis in Mexico from 2020 to 2040","authors":"Claudia Mendoza-Pinto ,&nbsp;Pamela Munguía-Realpozo ,&nbsp;Ivet Etchegaray-Morales ,&nbsp;Roberto Berra-Romani ,&nbsp;Edith Ramírez-Lara ,&nbsp;Socorro Méndez-Martínez ,&nbsp;Alvaro José Montiel-Jarquín ,&nbsp;Gabriela Medina-Valeriano ,&nbsp;Jorge Ayón-Aguilar","doi":"10.1016/j.arcmed.2025.103270","DOIUrl":"10.1016/j.arcmed.2025.103270","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Rheumatoid arthritis (RA) can lead to disability and premature death. Knowledge of the RA burden is necessary for strategic healthcare management, resource allocation, and preventive measures. The burden of RA was analyzed with projected rates for 2030 and 2040.</div></div><div><h3>Methods</h3><div>Incidence, prevalence, mortality, and burden of suffering from RA were analyzed using the most recent Global Burden of Disease (GBD) dataset for RA from 1990 to 2019. Predictive estimates were calculated using the SPSS Time Series Modeler.</div></div><div><h3>Results</h3><div>In 2019, approximately 530,000 individuals had RA (64.0 % were female, and 35.9 % were between 15 and 49 years old). The age-standardized prevalence (ASP) and incidence (ASI) rates were 427.6 and 25.4 cases per 100,000 people, respectively. The Mexican states with the highest ASP, disability-adjusted life years (DALY), and years of healthy life lost due to disability rates were Oaxaca, Tlaxcala, and Zacatecas. The national ASP and ASI rates of RA are projected to increase to 465.5 and 27.9 by 2030, and to 518.9 and 30.2 per 100,000 inhabitants by 2040, respectively. In contrast, age-standardized mortality and DALY rates are projected to decline to 1.2 and 77.8 in 2030 and 1.1 and 73.6 per 100,000 inhabitants in 2040, respectively.</div></div><div><h3>Conclusions</h3><div>The burden of RA, especially the burden of disability continues to increase. Despite substantial investments in clinical care, research, and public health initiatives, the rate of increase shows no signs of abating. Certain regions of Mexico, such as Oaxaca, Tlaxcala, and Zacatecas, have a disproportionately high burden.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"57 1","pages":"Article 103270"},"PeriodicalIF":3.4,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144866410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Cortical and Trabecular Bone Structure Between Patients With Type 2 Diabetes and Healthy Controls","authors":"Griselda-Adriana Cruz-Priego ,&nbsp;Miguel Ángel Guagnelli ,&nbsp;Sergio Ortiz Santiago ,&nbsp;Karina Geraldine González Castelan ,&nbsp;Rita A. Gomez-Diaz ,&nbsp;Ludovic Humbert ,&nbsp;Patricia Clark","doi":"10.1016/j.arcmed.2025.103269","DOIUrl":"10.1016/j.arcmed.2025.103269","url":null,"abstract":"<div><h3>Background and Aims</h3><div>This study evaluates three-dimensional dual-energy X-ray absorptiometry (3D-DXA) parameters that determine the cortical and trabecular compartments in patients with type 2 diabetes (T2D) compared to nondiabetic subjects, with the aim of identifying their determinants.</div></div><div><h3>Methods</h3><div>Patients with T2D were diagnosed according to ADA criteria. Anthropometric measurements were taken, and body mass index (BMI) was calculated. Bone densitometry (DXA) images were analyzed with 3D Shaper software. Volumetric bone mineral density (vBMD), bone mineral content (BMC), and volume were calculated in various regions of the femur, along with cortical thickness. Data analysis was performed using SPSS 27.0, a Student <em>t</em>-test and ANCOVA.</div></div><div><h3>Results</h3><div>A total of 125 subjects were recruited: 51 healthy controls and 74 patients with T2D (70.3 % women), with an average age of 53.9 and 53.6 years, respectively. The average disease duration in the T2D group was 11.4 years. Significant vitamin D deficiencies (levels &lt;20 ng/mL) were found in 56 % of the control group and in 64 % of the T2D group. No significant differences in aBMD were observed between the two groups. 3D-DXA analysis showed consistently lower vBMD in patients with T2D vs. controls, with significant differences in the trochanter, femoral neck, and average cortical thickness. A positive correlation was observed between waist circumference, BMI, and higher bone density in all regions.</div></div><div><h3>Conclusions</h3><div>This study demonstrates the potential of 3D-DXA to detect cortical and trabecular bone differences in patients with T2D, undetectable by aBMD. Women with T2D showed lower bone parameters in the trochanter and femoral neck, consistent with research linking long-term T2D and poor glycemic control to compromised bone quality.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"57 1","pages":"Article 103269"},"PeriodicalIF":3.4,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144866488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment of High-Altitude Reference Values for the Pan-Immune-Inflammation Value in Healthy Adults Living in Mexico City","authors":"Luis M Amezcua-Guerra ,&nbsp;Malinalli Brianza-Padilla ,&nbsp;Mireya Martínez-García ,&nbsp;Guadalupe Gutiérrez-Esparza","doi":"10.1016/j.arcmed.2025.103281","DOIUrl":"10.1016/j.arcmed.2025.103281","url":null,"abstract":"<div><h3>Background</h3><div>The Pan-Immune-Inflammation Value (PIV) is a novel composite biomarker that combines neutrophil, monocyte, platelet, and lymphocyte counts. It is useful for prognostic stratification across various clinical conditions. However, reference values for PIV have predominantly been established in populations living below 1000 m, which limits its applicability in high-altitude regions.</div></div><div><h3>Aim</h3><div>To establish reference values for PIV and its hematological components in healthy adults living in Mexico City.</div></div><div><h3>Methods</h3><div>Data from the Tlalpan 2020 cohort, a prospective study of healthy adults aged 20–50 from Mexico City, were analyzed. Reference values were determined following the Clinical and Laboratory Standards Institute guidelines, with stratification by sex.</div></div><div><h3>Results</h3><div>A total of 2290 participants (63% women) with a mean age of 37.0 ± 9.1 years were included. The mean PIV was 249.6 ± 416.9, which decreased to 221.9 ± 332.2 after excluding outliers. Significant sex differences were observed, with women exhibiting higher PIV values. The reference ranges for the total cohort were 65.8–491.6, with sex-specific ranges of 66.7–519.1 for women and 62.8–441.3 for men. Women also had higher reference values for neutrophils and platelets, while monocytes and lymphocytes were similar between sexes.</div></div><div><h3>Conclusions</h3><div>This study provides high-altitude-specific reference values for PIV and its components in Mexico City’s population, which are notably lower than those in low-altitude regions. The observed sex differences highlight the importance of considering sex as a biological variable when interpreting immunoinflammatory biomarkers.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"57 1","pages":"Article 103281"},"PeriodicalIF":3.4,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144866389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling Longitudinal Weight Dynamics in Type 2 Diabetes: Insights From a Comprehensive Care Program","authors":"Ana C. García-Ulloa ,&nbsp;Liliana Pérez-Peralta ,&nbsp;Luz E. Urbina-Arronte ,&nbsp;José L. Cárdenas-Fragoso ,&nbsp;Maria V. Landa-Anell ,&nbsp;Marco A. Melgarejo-Hernández ,&nbsp;Valeria Miranda Gil ,&nbsp;Sergio Ponce-de-León ,&nbsp;Sergio Hernández-Jiménez ,&nbsp;Group of Study CAIPaDi","doi":"10.1016/j.arcmed.2025.103271","DOIUrl":"10.1016/j.arcmed.2025.103271","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Overweight and obesity are prevalent conditions that contribute to significant health problems, including type two diabetes (T2D). Moderate weight loss improves metabolic control and cardiovascular risk. We aimed to identify the demographic and clinical characteristics of patients with T2D who experienced weight changes after a multidisciplinary intervention.</div></div><div><h3>Methods</h3><div>We analyzed 622 patients with complete 3-year follow-up information. Inclusion criteria were less than 5-years since diabetes diagnosis and an absence of disabling chronic complications. Descriptive statistics, ANOVA or Kruskal-Wallis tests were used for group comparisons, and logistic regression to identify predictors of weight change.</div></div><div><h3>Results</h3><div>Participants were 56.2 % women, with an average age of 55.8 ± 10.5 years. 53 % were overweight and 47 % were obese at baseline. At 3-years, 35.5 % lost weight, 33.9 % maintained weight, and 30.5 % gained weight; 16.6 % achieved a normal weight. Patients who gained weight were younger than those who lost or maintained it (60 vs. 61 years, <em>p</em> = 0.04). Higher baseline HbA1c (OR 1.14, 95 % CI 1.03–1.26, <em>p</em> = 0.008) and lower quality of life at three months (OR 1.48, 95 % CI 0.95–2.28, <em>p</em> = 0.07) were associated with weight gain. Higher baseline BMI (OR 0.90, 95 % CI 0.85–0.95, <em>p</em> &lt; 0.001), longer diabetes duration (OR 0.81, 95 % CI 0.70–0.94, <em>p</em> = 0.005), and iSGLT2 treatment were linked to weight loss.</div></div><div><h3>Conclusion</h3><div>Only 16 % of patients achieved normal weight after 3-years: 35.5 % lost weight, 33.9 % maintained their weight, and 30.5 % gained weight. Identifying predictors of weight change may guide targeted interventions in diabetes care.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"57 1","pages":"Article 103271"},"PeriodicalIF":3.4,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144866489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}