Archives of Medical Research最新文献

{"title":"Pharmacogenetic Drug Administration and Community Health: A Cross-Sectional Telecommunication-Based Study","authors":"Nina D. Anfinogenova ,&nbsp;Vadim A. Stepanov ,&nbsp;Alina D. Kuznetsova ,&nbsp;Nazary P. Chesalov ,&nbsp;Sergey V. Popov ,&nbsp;Alexey N. Repin","doi":"10.1016/j.arcmed.2025.103307","DOIUrl":"10.1016/j.arcmed.2025.103307","url":null,"abstract":"<div><h3>Purpose</h3><div>Drugs are considered pharmacogenetic (PGx) when genetic variants impact their efficacy, metabolism, or toxicity due to drug-gene interactions. This study aimed to elucidate PGx drug intake patterns in population samples.</div></div><div><h3>Methods</h3><div>The Short Message Service (SMS) invitations were sent to randomly selected adult clients of a telecommunication company. A total of 2,149 respondents were enrolled. The online questionnaire included questions on demographic, clinical, pharmacological, behavioral, and other factors. PharmGKB resources were used to identify PGx genes potentially involved in pharmacotherapy outcomes. Proneness to adverse drug reactions (ADRs) was assessed based on the ADR index (ADRi).</div></div><div><h3>Results</h3><div>Most respondents (68.45%) were taking pharmacotherapy (433 drugs) associated with 839 PGx genes. The top five PGx drugs included bisoprolol, aspirin, losartan, indapamide, and omeprazole. The five most important PGx gene families involved in pharmacotherapy were <em>CYP, UGT, SLC, IL,</em> and <em>HLA</em>. The top five PGx genes were: <em>CYP3A5, ABCB1, CYP2D6, CYP2C9,</em> and <em>ACE</em>. The number of PGx genes per drug ranged from 0 to 138. A high number of PGx genes associated with pharmacotherapy were observed in patients with coronary artery disease, diabetes mellitus, endocrine diseases, dyssomnia, and rheumatic diseases. PGx burden significantly correlated with health conditions, median ADRi values, health-related behavioral traits, and clinical-pharmacology characteristics (<em>p</em> &lt;0.001).</div></div><div><h3>Conclusion</h3><div>The high prevalence of PGx drug utilization encourages the implementation of pre-emptive PGx testing. In the meantime, medical history taking, dose adjustment, assessment of drug blood concentrations, and committing to medical minimalism may prevent PGx-triggered ADRs.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"57 3","pages":"Article 103307"},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145119493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Narrowing the Gap: Understanding Lung Cancer Care Intervals and Their Barriers in Latin American Low and Middle-Income Countries” [Archives of Medical Research 56 (2025) 103202/Article Number ARCMED-D-24-00358]","authors":"Oscar Arrieta ,&nbsp;Cittim B. Palomares-Palomares ,&nbsp;Ana Pamela Gómez-García ,&nbsp;Eduardo Rios-Garcia ,&nbsp;Juan-Manuel Hernandez-Martinez ,&nbsp;Jenny G. Turcott ,&nbsp;Diana Flores-Estrada ,&nbsp;Haydee Williams ,&nbsp;Nancy Reynoso-Noverón ,&nbsp;Wendy R. Muñoz-Montaño ,&nbsp;Jose Corona-Cruz ,&nbsp;Vanessa Cores ,&nbsp;Andrés F. Cardona","doi":"10.1016/j.arcmed.2026.103390","DOIUrl":"10.1016/j.arcmed.2026.103390","url":null,"abstract":"","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"57 3","pages":"Article 103390"},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146184683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Baseline Autonomic Nervous System Activity Affect the Outcomes of Transcutaneous Auricular Vagus Nerve Stimulation?","authors":"Alper Percin ,&nbsp;Ali Veysel Ozden ,&nbsp;Semiha Yenisehir ,&nbsp;Berkay Eren Pehlivanoglu ,&nbsp;Ramazan Cihad Yılmaz","doi":"10.1016/j.arcmed.2025.103324","DOIUrl":"10.1016/j.arcmed.2025.103324","url":null,"abstract":"<div><h3>Aim</h3><div>Transcutaneous auricular vagus nerve stimulation (taVNS) has recently emerged as an effective neuromodulation method. A preliminary evaluation based on heart rate variability (HRV) could predict those who would benefit most from taVNS. This study investigated the efficacy of taVNS in healthy subjects according to the baseline activity range of the parasympathetic (PNS) and sympathetic nervous system (SNS) indexes.</div></div><div><h3>Methods</h3><div>76 healthy participants were enrolled in the study. HRV, pulse rate, and systolic and diastolic blood pressure (SBP and DBP) were measured at baseline and after taVNS. The procedure was repeated after 48–72 h.</div></div><div><h3>Results</h3><div>In the first intervention, the PNS index increased in group 1 (<em>p</em> &lt;0.001), and the SNS index decreased in groups 1 and 3 (<em>p</em> &lt;0.001). In the second intervention, the PNS index increased in groups 1, 2, and 4 (<em>p</em> = 0.001, <em>p</em> = 0.018, and <em>p</em> = 0.003, respectively), while the SNS index decreased in groups 1 and 3 (both <em>p</em> = 0.001). SBP and DBP decreased in all groups after both interventions. After the first intervention, the PNS index was higher in group 1 than in groups 3 and 4 (<em>p</em> = 0.001 and <em>p</em> &lt;0.001, respectively), and the SNS index and SBP were lower in group 1 than in group 3 (both <em>p</em> &lt;0.05). After the second intervention, the PNS index was higher and the SNS index was lower in group 1 than in group 3 (<em>p</em> &lt;0.05).</div></div><div><h3>Conclusions</h3><div>Subjects with low parasympathetic or high sympathetic activity may be more responsive to taVNS.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"57 3","pages":"Article 103324"},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Bisphenol A and its Analogues on Epigenetics and their Impact on the Developmental Origins of Female and Male Reproductive Disorders","authors":"Alejandra Martínez-Ibarra ,&nbsp;Luis Daniel Martínez-Razo ,&nbsp;Miguel Morales-Pacheco ,&nbsp;Ignacio González-Sánchez ,&nbsp;Mauricio Rodríguez-Dorantes ,&nbsp;Marco Cerbón","doi":"10.1016/j.arcmed.2026.103380","DOIUrl":"10.1016/j.arcmed.2026.103380","url":null,"abstract":"<div><div>Reproductive disorders may originate from many factors including exposure to environmental chemicals in the womb or during the early stages of postnatal life. Throughout these stages, the exposure to endocrine-disrupting chemicals (EDCs), such as bisphenols, can disrupt reproductive function. These compounds cross the placenta and cause long-term epigenetic alterations in the fetus. Bisphenols are a large class of chemicals mainly used in the plastic industry and epoxy resin production. Bisphenol A (BPA) was the first and most widely used compound; however, it acts as a hormone by binding to estrogen receptors (ERs), affecting estrogen-dependent functions. As a result, BPA has been replaced by analogues or similar compounds, such as bisphenol F (BPF), bisphenol S (BPS), bisphenol B (BPB), and bisphenol AF (BPAF), among others. Although these compounds were originally synthesized to be safe for human use, they have also exhibited endocrine-disrupting activity similar to BPA, which affects reproductive function. BPA analogues also induce epigenetic changes, such as DNA methylation, histone modification, chromatin remodeling, and non-coding RNA regulation. These changes can lead to reproductive disorders and negative long-term and transgenerational consequences. This narrative review includes <em>in vivo, in vitro,</em> and human cohort studies that examine how BPA and its analogues affect male and female reproductive function through epigenetic mechanisms. Through this pathway, these chemical compounds have the potential to modify developmental programming.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"57 3","pages":"Article 103380"},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146133951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Dietary Patterns in Patients with Type 2 Diabetes and Microvascular Complications","authors":"Sandra Lorena García-Del-Río ,&nbsp;Adriana Leticia Valdez-Gonzalez ,&nbsp;Rita A. Gómez-Díaz ,&nbsp;Hortensia Reyes-Morales ,&nbsp;Monica Leonor Ruiz-Martínez ,&nbsp;Victor Hugo Borja Aburto ,&nbsp;Niels H. Wacher","doi":"10.1016/j.arcmed.2026.103381","DOIUrl":"10.1016/j.arcmed.2026.103381","url":null,"abstract":"<div><h3>Background</h3><div>Few studies have examined the relationship between dietary patterns and microvascular complications in patients with type 2 diabetes (T2D) to develop targeted management strategies.</div></div><div><h3>Objective</h3><div>To evaluate the association of dietary patterns and chronic microvascular complications in patients with T2D.</div></div><div><h3>Methods</h3><div>A nested case-control study of 5,154 patients with T2D diagnosed for &lt;15 years, treated in primary care units in Mexico City and its metropolitan area. Microvascular complications (retinopathy, neuropathy, and nephropathy) were evaluated. Dietary data were obtained using a validated food frequency questionnaire. Principal component analysis identified dietary patterns, and multivariate analysis evaluated the association between microvascular complications and dietary patterns, adjusting for confounding variables.</div></div><div><h3>Results</h3><div>A total of 3,423 patients were included, 59.1% of whom had microvascular complications. Six dietary patterns were identified, three of which were associated with microvascular complications. After adjusting for glycemic control (glycated hemoglobin &lt;7 %), sex, blood pressure, body mass index, antihypertensive and lipid-lowering treatment, physical activity, and lipid profile, the highest quartile of the “Legumes and fats” pattern (OR: 2.191; 1.789–2.684; <em>p</em> &lt;0.001) and the “Mexican food” pattern (OR: 1.231; 95% CI: 1.004–1.510; <em>p</em> = 0.046) were associated with an increased risk of microvascular complications.</div><div>Conversely, high consumption of the “Healthy” pattern (OR: 0.81; 95% CI: 0.66–0.98; <em>p</em> = 0.037) was associated with a reduced risk.</div></div><div><h3>Conclusion</h3><div>The consumption of the “Legumes and fats” and “Mexican food” dietary patterns was associated with microvascular complications, while a higher consumption of the “Healthy” pattern was protective. These findings may be useful for providing specific nutritional recommendations in the management for patients with T2D.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"57 3","pages":"Article 103381"},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Neonatal Autonomic and Adrenocorticotropic Features in the Offspring of Mothers in the Gestational Diabetes”","authors":"PARTH APHALE,&nbsp;HIMANSHU SHEKHAR,&nbsp;SHASHANK DOKANIA","doi":"10.1016/j.arcmed.2026.103398","DOIUrl":"10.1016/j.arcmed.2026.103398","url":null,"abstract":"","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"57 3","pages":"Article 103398"},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146159704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Pilot Human Papillomavirus Self-Sampling Program in Workplaces in Ciudad Juárez, Mexico","authors":"Svetlana V. Doubova ,&nbsp;Saúl Eduardo Contreras-Sánchez ,&nbsp;Sean P. McClellan ,&nbsp;Patricia Piña-Sánchez","doi":"10.1016/j.arcmed.2025.103316","DOIUrl":"10.1016/j.arcmed.2025.103316","url":null,"abstract":"<div><h3>Objective</h3><div>To examine cervical cancer screening (CCS) coverage and follow-up before and after the introduction of the workplace Human Papilloma Virus self-sampling pilot program (HPV-SS-PP) for female factory workers in Ciudad Juárez, Mexico and to compare HPV-SS with conventional cervical cytology screening using the Papanicolaou (Pap) smear method.</div></div><div><h3>Methods</h3><div>A secondary analysis was conducted using the Instituto Mexicano del Seguro Social (IMSS) cancer registry, the HPV-SS-PP registry, and the IMSS affiliation database. The study focused on IMSS-affiliated working women aged 35–64 living in Ciudad Juárez. We examined trends in CCS coverage during the 38 months before and the first 12 months after the HPV-SS-PP. We also examined HPV prevalence and follow-up indicators for HPV-positive women.</div></div><div><h3>Results</h3><div>The study found that 44.8% of factories and 42.7% of women accepted the HPV-SS-PP program, leading to an initial increase and subsequent slowdown in CCS coverage. The HPV-16/18 genotype prevalence was 5%, and the HPV-pool prevalence was 18.1%. Follow-up for cervical cytology among women testing positive for the HPV-pool was 39.7%. Colposcopy and histopathology follow-up for HPV-16/18 genotypes and HPV-pool were moderate to high (64.8 and 84.7% for colposcopy, 87.8 and 93.2% for histopathology follow-up, respectively).</div></div><div><h3>Conclusion</h3><div>The HPV-SS-PP requires improvements to increase working women’s participation in CCS and ensure better follow-up of positive HPV results.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"57 3","pages":"Article 103316"},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145108116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep as a Mediator: Decoding the Complex Relationship Between Coffee, Exercise, and Semen quality","authors":"Yu Liu ,&nbsp;Wenrui Lu ,&nbsp;Guanxiang Yuan ,&nbsp;Qi Zhou ,&nbsp;Benhong Xu ,&nbsp;Jianjun Liu ,&nbsp;Peiyi Liu","doi":"10.1016/j.arcmed.2025.103317","DOIUrl":"10.1016/j.arcmed.2025.103317","url":null,"abstract":"<div><h3>Objectives</h3><div>Given the global decline in semen quality, it is crucial to investigate the modifiable factors, such as lifestyle that influence semen quality in men. This cross-sectional observational study evaluated the association between coffee intake, physical activity, sleep, and semen quality.</div></div><div><h3>Methods</h3><div>A total of 3,302 male participants, aged 18–60 years, underwent urological assessments, provided semen samples, and participated in anthropometric measurements and a questionnaire addressing lifestyle factors related to semen quality. A multiple linear regression model was used to examine the associations between coffee consumption, physical activity, sleep, and semen quality. Furthermore, mediation models were developed to explore the potential mediating role of sleep in the relationship between coffee intake, physical activity, and semen quality.</div></div><div><h3>Results</h3><div>The results showed that not drinking coffee was positively associated with the sperm total motility rate, and the sperm progressive motility rate, and negatively associated with the sperm immotility rate. Physical activity was also positively correlated with semen volume. Subgroup analysis showed that physical activity mitigated the effect of coffee on semen quality. In addition, mediation analysis revealed that the time of falling asleep mediated the relationship between coffee consumption and semen quality. Moreover, the average duration of nightly sleep mediated the relationship between physical activity and various semen motility parameters.</div></div><div><h3>Conclusions</h3><div>The associations among coffee intake, physical activity, sleep and semen quality were statistically significant. These findings highlight the importance of a healthy lifestyle for optimal male semen quality.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"57 3","pages":"Article 103317"},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145093073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controlled Ovarian Stimulation Contributes to the Incidence of de Novo Chromosomal Abnormalities in Cleavage-Stage Embryos","authors":"Yinghui Ye ,&nbsp;Jieliang Ma ,&nbsp;Qitao Zhan ,&nbsp;Ruimin Zhao ,&nbsp;Xinyun Yang ,&nbsp;Yangyun Zou ,&nbsp;Fan Jin","doi":"10.1016/j.arcmed.2025.103318","DOIUrl":"10.1016/j.arcmed.2025.103318","url":null,"abstract":"<div><h3>Background</h3><div>Studies on the effects of ovarian stimulation on the embryo aneuploidy rate have shown conflicting results.</div></div><div><h3>Objectives</h3><div>To investigate whether parameters of controlled ovarian stimulation (COS) are associated with the incidence of <em>de novo</em> chromosomal abnormalities in cleavage-stage embryos undergoing preimplantation genetic testing (PGT).</div></div><div><h3>Methods</h3><div>This retrospective study examined data from biopsies of cleavage-stage embryos with one blastomere from the Women’s Hospital at Zhejiang University School of Medicine. <em>De novo</em> chromosomal abnormalities were classified as: <em>de novo</em> chromosomal segmental abnormalities (DCSAs) or <em>de novo</em> whole chromosomal abnormalities (DWCAs). A multivariable logistic regression model was used to identify factors that may affect the genomic stability of embryos. Further stratification analysis was performed to explore the impact of these factors on DCSAs and DWCAs.</div></div><div><h3>Results</h3><div>A total of 1,994 cleavage-stage biopsied embryos were included in the analysis. The number of DWCAs but not DCSAs increased significantly with maternal age. The incidence of <em>de novo</em> chromosomal abnormalities was similar between different COS protocols. Longer stimulation duration was associated with a considerably higher DWCA rate (<em>p</em> = 0.003). The DCSA rate increased with higher gonadotropin dosages. Furthermore, cotreatment with growth hormone (GH) supplementation was associated with a significantly lower incidence of DWCAs (<em>p</em> = 0.006).</div></div><div><h3>Conclusion</h3><div>Ovarian stimulation parameters are related to the incidence of <em>de novo</em> chromosomal abnormalities in preimplantation embryos. GH supplementation had a beneficial effect in decreasing aneuploidy, and higher gonadotropin doses may be related to mitotic errors.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"57 3","pages":"Article 103318"},"PeriodicalIF":3.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factor VIII Pharmacokinetics in Mexican Patients With Hemophilia A","authors":"Jesús Hernandez-Juarez ,&nbsp;Guillermo Espejo-Godinez ,&nbsp;Julieta Espinoza-Islas ,&nbsp;Victor Manuel Dominguez Reyes ,&nbsp;Jaime Garcia-Chavez ,&nbsp;Berenice Fernandez-Rojas ,&nbsp;Abraham Majluf-Cruz","doi":"10.1016/j.arcmed.2025.103290","DOIUrl":"10.1016/j.arcmed.2025.103290","url":null,"abstract":"<div><h3>Introduction</h3><div>Treatment of patients with severe hemophilia A requires the replacement of deficient factor VIII. To reach the international standards of care, an optimal dose of factor VIII should be administered based on pharmacokinetic analysis. However, in Mexico factor VIII pharmacokinetics is not used. Therefore, this study aimed to determine, for the first time, the pharmacokinetic parameters of factor VIII in Mexican patients with severe hemophilia A.</div></div><div><h3>Methods</h3><div>Fifteen samples from patients with severe hemophilia A under prophylactic treatment were analyzed. Factor VIII activity was determined before infusion at 0.25, 0.5, 1.0, 4.0, 8.0, 12, and 48 h after infusion of a standardized dose of factor VIII (40 UI/kg). WinNolin software was used to establish a mono- and bi-compartmental models to obtain the following parameters: area under the curve, maximum activity, <em>in vivo</em> recovery, distribution volume, half-life time, mean residence time, clearance, minimum activity, and elimination constant.</div></div><div><h3>Results</h3><div>Factor VIII pharmacokinetics was highly variable among our patients who frequently received overdosage of factor VIII. The bi-compartmental model better explained the behavior of factor VIII in patients with hemophilia A.</div></div><div><h3>Conclusions</h3><div>Compared with the regimens based on body weight, factor VIII pharmacokinetics shows that the response to factor VIII treatment differs greatly among our patients. Our results strongly suggest that factor VIII treatment must be personalized, regardless of body weight. The lack of evidence and experience on factor VIII pharmacokinetics in our country may represent an obstacle to the future use of extended half-life recombinant factor VIII products.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"57 2","pages":"Article 103290"},"PeriodicalIF":3.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144989548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}