Luis M Amezcua-Guerra , Malinalli Brianza-Padilla , Mireya Martínez-García , Guadalupe Gutiérrez-Esparza
{"title":"墨西哥城健康成人泛免疫炎症值高海拔参考值的建立","authors":"Luis M Amezcua-Guerra , Malinalli Brianza-Padilla , Mireya Martínez-García , Guadalupe Gutiérrez-Esparza","doi":"10.1016/j.arcmed.2025.103281","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>The Pan-Immune-Inflammation Value (PIV) is a novel composite biomarker that combines neutrophil, monocyte, platelet, and lymphocyte counts. It is useful for prognostic stratification across various clinical conditions. However, reference values for PIV have predominantly been established in populations living below 1000 m, which limits its applicability in high-altitude regions.</div></div><div><h3>Aim</h3><div>To establish reference values for PIV and its hematological components in healthy adults living in Mexico City.</div></div><div><h3>Methods</h3><div>Data from the Tlalpan 2020 cohort, a prospective study of healthy adults aged 20–50 from Mexico City, were analyzed. Reference values were determined following the Clinical and Laboratory Standards Institute guidelines, with stratification by sex.</div></div><div><h3>Results</h3><div>A total of 2290 participants (63% women) with a mean age of 37.0 ± 9.1 years were included. The mean PIV was 249.6 ± 416.9, which decreased to 221.9 ± 332.2 after excluding outliers. Significant sex differences were observed, with women exhibiting higher PIV values. The reference ranges for the total cohort were 65.8–491.6, with sex-specific ranges of 66.7–519.1 for women and 62.8–441.3 for men. Women also had higher reference values for neutrophils and platelets, while monocytes and lymphocytes were similar between sexes.</div></div><div><h3>Conclusions</h3><div>This study provides high-altitude-specific reference values for PIV and its components in Mexico City’s population, which are notably lower than those in low-altitude regions. The observed sex differences highlight the importance of considering sex as a biological variable when interpreting immunoinflammatory biomarkers.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"57 1","pages":"Article 103281"},"PeriodicalIF":3.4000,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Establishment of High-Altitude Reference Values for the Pan-Immune-Inflammation Value in Healthy Adults Living in Mexico City\",\"authors\":\"Luis M Amezcua-Guerra , Malinalli Brianza-Padilla , Mireya Martínez-García , Guadalupe Gutiérrez-Esparza\",\"doi\":\"10.1016/j.arcmed.2025.103281\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>The Pan-Immune-Inflammation Value (PIV) is a novel composite biomarker that combines neutrophil, monocyte, platelet, and lymphocyte counts. It is useful for prognostic stratification across various clinical conditions. However, reference values for PIV have predominantly been established in populations living below 1000 m, which limits its applicability in high-altitude regions.</div></div><div><h3>Aim</h3><div>To establish reference values for PIV and its hematological components in healthy adults living in Mexico City.</div></div><div><h3>Methods</h3><div>Data from the Tlalpan 2020 cohort, a prospective study of healthy adults aged 20–50 from Mexico City, were analyzed. Reference values were determined following the Clinical and Laboratory Standards Institute guidelines, with stratification by sex.</div></div><div><h3>Results</h3><div>A total of 2290 participants (63% women) with a mean age of 37.0 ± 9.1 years were included. The mean PIV was 249.6 ± 416.9, which decreased to 221.9 ± 332.2 after excluding outliers. Significant sex differences were observed, with women exhibiting higher PIV values. The reference ranges for the total cohort were 65.8–491.6, with sex-specific ranges of 66.7–519.1 for women and 62.8–441.3 for men. Women also had higher reference values for neutrophils and platelets, while monocytes and lymphocytes were similar between sexes.</div></div><div><h3>Conclusions</h3><div>This study provides high-altitude-specific reference values for PIV and its components in Mexico City’s population, which are notably lower than those in low-altitude regions. The observed sex differences highlight the importance of considering sex as a biological variable when interpreting immunoinflammatory biomarkers.</div></div>\",\"PeriodicalId\":8318,\"journal\":{\"name\":\"Archives of Medical Research\",\"volume\":\"57 1\",\"pages\":\"Article 103281\"},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2025-08-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Archives of Medical Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0188440925001018\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of Medical Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0188440925001018","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
Establishment of High-Altitude Reference Values for the Pan-Immune-Inflammation Value in Healthy Adults Living in Mexico City
Background
The Pan-Immune-Inflammation Value (PIV) is a novel composite biomarker that combines neutrophil, monocyte, platelet, and lymphocyte counts. It is useful for prognostic stratification across various clinical conditions. However, reference values for PIV have predominantly been established in populations living below 1000 m, which limits its applicability in high-altitude regions.
Aim
To establish reference values for PIV and its hematological components in healthy adults living in Mexico City.
Methods
Data from the Tlalpan 2020 cohort, a prospective study of healthy adults aged 20–50 from Mexico City, were analyzed. Reference values were determined following the Clinical and Laboratory Standards Institute guidelines, with stratification by sex.
Results
A total of 2290 participants (63% women) with a mean age of 37.0 ± 9.1 years were included. The mean PIV was 249.6 ± 416.9, which decreased to 221.9 ± 332.2 after excluding outliers. Significant sex differences were observed, with women exhibiting higher PIV values. The reference ranges for the total cohort were 65.8–491.6, with sex-specific ranges of 66.7–519.1 for women and 62.8–441.3 for men. Women also had higher reference values for neutrophils and platelets, while monocytes and lymphocytes were similar between sexes.
Conclusions
This study provides high-altitude-specific reference values for PIV and its components in Mexico City’s population, which are notably lower than those in low-altitude regions. The observed sex differences highlight the importance of considering sex as a biological variable when interpreting immunoinflammatory biomarkers.
期刊介绍:
Archives of Medical Research serves as a platform for publishing original peer-reviewed medical research, aiming to bridge gaps created by medical specialization. The journal covers three main categories - biomedical, clinical, and epidemiological contributions, along with review articles and preliminary communications. With an international scope, it presents the study of diseases from diverse perspectives, offering the medical community original investigations ranging from molecular biology to clinical epidemiology in a single publication.