rs.11196205 TCF7L2基因变异与高血压和糖尿病患者心血管风险增加相关

IF 3.4 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Archives of Medical Research Pub Date : 2025-08-20 DOI:10.1016/j.arcmed.2025.103268

Lívia da Cunha Agostini , Letícia Fernandes Dias Coelho , Renata Bárbara Machado e Silva , Nayara Nascimento Toledo Silva , Ana Cláudia Faria Lopes , Vanessa de Almeida Belo , Wendel Coura-Vital , Luiz Fernando de Medeiros Teixeira , Angélica Alves Lima , Glenda Nicioli da Silva

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引用次数: 0

摘要

背景与目的遗传多态性与环境因素之间的相互作用增加了发生与全身性动脉高血压（SAH）和心血管疾病相关的糖尿病表型的风险。t细胞因子7-样2 （TCF7L2）基因变异与2型糖尿病（T2DM）有关。探讨巴西SAH合并T2DM患者TCF7L2基因rs.11196205多态性与生化、人体测量参数及心血管危险指标的关系。方法采用TaqMan®系统，对664份样本进行qPCR检测：对照组（cg -无糖尿病或高血压）、糖尿病组（dg -正常）、高血压组（hg -无糖尿病）和高血压糖尿病组（HDG）。采用生化剂量测定脂质谱：甘油三酯（TG）、总胆固醇、HDL、LDL和尿酸。采用人体测量法测量体重指数（BMI）、内脏脂肪指数和心血管风险计算，包括血浆动脉粥样硬化指数（AIP）、内脏脂肪指数（VAI）、甘油三酯-葡萄糖（TyG）指数和尿酸/HDL-c比值（UA/HDL）。双变量逻辑回归用于识别与SAH和T2DM相关的变量。随后的分类变量分析采用多项逻辑回归。结果TCF7L2基因rs.11196205变异的GG基因型与高血压和糖尿病高血压的风险增加相关。GG基因型GHD组患者BMI参数和TyG指数值恶化。结论TCF7L2基因rs.11196205变异GG基因型是糖尿病高血压患者的心血管危险基因型。

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rs.11196205 Variant in the TCF7L2 Gene is Associated With an Increased Cardiovascular Risk in Individuals With Hypertension and Diabetes

Background and Aims

The interaction between genetic polymorphisms and environmental factors increases the risk of developing a diabetic phenotype which is associated with systemic arterial hypertension (SAH) and cardiovascular diseases. Variants in the T-cell factor 7-like 2 (TCF7L2) gene have been associated with type 2 diabetes mellitus (T2DM). To investigate the association of the rs.11196205 polymorphism of the TCF7L2 gene with biochemical and anthropometric parameters and cardiovascular risk indices in Brazilian patients with SAH and T2DM.

Methods

The polymorphism was identified by qPCR in 664 samples from four groups: Control (CG-without diabetes or hypertension), diabetic (DG-normotensive), hypertensive (HG-without diabetes) and hypertensive diabetic (HDG), using the TaqMan® system. Biochemical dosages were taken for the lipid profile: triglycerides (TG), total cholesterol, HDL, LDL, and uric acid. Anthropometric measurements were taken for body mass index (BMI), visceral fat index and cardiovascular risk calculations, including the atherogenic index of plasma (AIP), visceral adiposity index (VAI), triglyceride-glucose (TyG) index and uric acid/HDL-c ratio (UA/HDL). Bivariate logistic regression was used to identify variables associated with SAH and T2DM. Subsequent categorical variables were analyzed using multinomial logistic regression.

Results

The GG genotype of the rs.11196205 variant of the TCF7L2 gene was associated with an increased risk of hypertension and diabetic hypertension. Patients in the GHD group with the GG genotype showed worsening BMI parameters and TyG index values.

Conclusion

The GG genotype of the rs.11196205 variant of the TCF7L2 gene acts as a cardiovascular risk genotype in patients with diabetic hypertension.

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来源期刊

Archives of Medical Research 医学-医学：研究与实验

CiteScore

12.50

自引率

0.00%

发文量

审稿时长

28 days

期刊介绍： Archives of Medical Research serves as a platform for publishing original peer-reviewed medical research, aiming to bridge gaps created by medical specialization. The journal covers three main categories - biomedical, clinical, and epidemiological contributions, along with review articles and preliminary communications. With an international scope, it presents the study of diseases from diverse perspectives, offering the medical community original investigations ranging from molecular biology to clinical epidemiology in a single publication.