Archives of Medical Research最新文献

{"title":"Epidemiologic Characterization and Risk Factors of Rocky Mountain Spotted Fever in Children in Northeastern Mexico: A Retrospective Cross-sectional Study (2018–2024)","authors":"José Iván Castillo Bejarano ,&nbsp;Érika Aidé Larragoity González ,&nbsp;Susana Patricia Cantú González ,&nbsp;Abiel Homero Mascareñas de los Santos ,&nbsp;Rodrigo García Pérez ,&nbsp;Sara Paulina Rosales-González ,&nbsp;Diego Armando Alvarado Lara ,&nbsp;María Fernanda Cid Ramírez ,&nbsp;Alfredo Castillo Mariscal ,&nbsp;Denisse Natalie Vaquera Aparicio","doi":"10.1016/j.arcmed.2025.103367","DOIUrl":"10.1016/j.arcmed.2025.103367","url":null,"abstract":"<div><h3>Background</h3><div>Rocky Mountain spotted fever (RMSF) is a vector-borne disease with nonspecific symptoms, including fever, headache, myalgia, and exanthema, which complicates timely diagnosis and treatment. Despite its significant morbidity and mortality, epidemiological data and risk factor analyses remain scarce in Mexico.</div></div><div><h3>Methods</h3><div>A retrospective cross-sectional study was conducted from 2018–2024 in three hospitals in northeastern Mexico. We analyzed 90 pediatric patients with confirmed rickettsiosis via polymerase chain reaction (PCR) or immunofluorescence assay (IFA). Demographic, clinical, and laboratory data were evaluated to identify independent risk factors associated with disease severity and outcomes. Statistical analyses included logistic regression, Mann-Whitney <em>U</em> tests, and Pearson χ² tests (<em>p</em> ≤0.05).</div></div><div><h3>Results</h3><div>School-aged children comprised 46.6% of cases, with a predominance of females (54.4%). Key epidemiological exposures included tick bites (17.8%) and pet cohabitation (54.5%). Delayed doxycycline treatment (&gt;5 d after symptom onset) was associated with increased mortality. Significant predictors of poor outcomes were neurological impairment (OR: 3.7, CI: 1.9–7.3), shock upon admission (OR: 4.5, CI: 2.2–9.1), and thrombocytopenia (<em>p</em> &lt; 0.001). The overall mortality rate was 36.7%.</div></div><div><h3>Conclusions</h3><div>Our findings underscore the significant clinical impact of rickettsioses in northeastern Mexico and the need to improve diagnostic capabilities, raising public awareness, and implementing effective vector control programs. Early recognition and timely doxycycline treatment are crucial to improving patient outcomes. Strengthening public health strategies through preventive measures and clinician education could reduce the morbidity and mortality associated with these infections.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"57 2","pages":"Article 103367"},"PeriodicalIF":3.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145901805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic Diversity and Geographic Distribution of SARS-CoV-2 in Mexico: Insights From 4 Years of Genomic Surveillance","authors":"Blanca Taboada ,&nbsp;Selene Zárate ,&nbsp;José Esteban Muñoz-Medina ,&nbsp;Alejandro Sanchez-Flores ,&nbsp;Alfredo Herrera-Estrella ,&nbsp;Bruno Gómez-Gil ,&nbsp;Joel Armando Vazquez-Perez ,&nbsp;Angel Gustavo Salas-Lais ,&nbsp;Alida Zárate ,&nbsp;Carlos F. Arias","doi":"10.1016/j.arcmed.2025.103289","DOIUrl":"10.1016/j.arcmed.2025.103289","url":null,"abstract":"<div><h3>Background</h3><div>As of September 2024, Mexico had reported over 7.6 million confirmed cases of COVID-19 and 334,785 deaths. Genomic surveillance has been essential, with 94,799 SARS-CoV-2 genomes sequenced nationwide, 38.5% by the Mexican Consortium for Genomic Surveillance (CoViGen-Mex).</div></div><div><h3>Aims</h3><div>Analyze the genomic diversity and geographic distribution of SARS-CoV-2 across Mexico’s nine pandemic waves, with an emphasis on the seventh to ninth waves.</div></div><div><h3>Methods</h3><div>Data from 94,799 SARS-CoV-2 genomes spanning from February 2020 to September 2024 were analyzed. Sublineages with a prevalence of at least 5% were tracked, and their temporal and regional trends were evaluated using diversity indices and statistical models.</div></div><div><h3>Results</h3><div>Of the 996 sublineages identified, 72 had a prevalence greater than 5%, and 33 exceeded 10%. Each wave featured dominant sublineages, some of which emerged locally and prevailed during one or more waves, but were later displaced by new ones. Regional differences were identified in all waves, driven by population density, mobility, and variant introductions.</div></div><div><h3>Conclusions</h3><div>Our findings highlight the dynamic evolution of SARS-CoV-2 in Mexico, the emergence of locally relevant variants, and the critical need for sustained genomic surveillance to guide public health strategies during the transition to an endemic state.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"57 2","pages":"Article 103289"},"PeriodicalIF":3.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144989556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Comment on: Evaluation of Multimorbidity Burden in Frailty Transitions in Costa Rican Older Adults Using Multistate Markov Models","authors":"RAFAEL OGAZ-GONZÁLEZ ,&nbsp;QIAN ZOU ,&nbsp;LUIS MIGUEL GUTIÉRREZ-ROBLEDO ,&nbsp;MALAQUÍAS LÓPEZ-CERVANTES ,&nbsp;EVA CORPELEIJN","doi":"10.1016/j.arcmed.2025.103299","DOIUrl":"10.1016/j.arcmed.2025.103299","url":null,"abstract":"","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"57 2","pages":"Article 103299"},"PeriodicalIF":3.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144997472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracellular Galectin-3 as a Crucial Regulator of Foam Cell Formation and Apoptosis Progression through the Modulation of Membrane Lipid Rafts","authors":"Wen-cheng Liu ,&nbsp;Chin-sheng Lin ,&nbsp;Chen-ling Luo ,&nbsp;Weng-yu Yang ,&nbsp;Cheng-hung Yang ,&nbsp;Mei-Ling Cheng ,&nbsp;Min-chien Tsai ,&nbsp;Wei-shiang Lin ,&nbsp;Hao-ai Shui ,&nbsp;Yi-ping Chuang","doi":"10.1016/j.arcmed.2025.103300","DOIUrl":"10.1016/j.arcmed.2025.103300","url":null,"abstract":"<div><h3>Background</h3><div>Atherosclerosis, a leading cause of cardiovascular disease (CVD) mortality worldwide, is characterized by dysregulated lipid metabolism and unresolved inflammation. Macrophage-derived foam cell formation and apoptosis contribute to plaque formation and vulnerability. Elevated serum galectin-3 (Gal-3) levels are associated with increased CVD risk, and Gal-3 in plaques is strongly associated with macrophages. However, its impact on inflammation remains controversial.</div></div><div><h3>Methods</h3><div>An <em>in vitro</em> model using human THP-1-derived macrophages was established to simulate inflammatory foam cells. CRISPR-Cas9-assisted LGALS3 knockout in THP-1 cells was performed to elucidate the functional role of Gal-3 in inflammation and apoptosis.</div></div><div><h3>Results</h3><div>OxLDL-internalized THP-1-derived foam cells secreted significant Gal-3 upon lipopolysaccharide (LPS) treatment, mimicking elevated Gal-3 levels observed in patients with CVD. LPS-treated foam cells showed Gal-3-dependent inflammation, endoplasmic reticulum stress, and apoptosis progression. LGALS3 knockout reduced oxLDL uptake and inflammation, accompanied by decreased surface expression of CD36 and CD14. This indicates a disrupted lipid raft structure, as confirmed by reduced cholera toxin B subunit recognition and altered sphingolipid profile. Gal-3 inhibitors GB1107 and TD139 attenuated LPS-induced cytokine production. Notably, only GB1107 inhibited oxLDL uptake by partially disrupting lipid raft organization, due to its superior membrane permeability. GB1107 further altered Gal-3 nuclear localization under LPS or oxLDL exposure, suggesting a potential nuclear role during inflammation. Importantly, GB1107 reduced foam cell formation in primary human monocyte-derived macrophages, supporting its translational relevance.</div></div><div><h3>Conclusions</h3><div>Gal-3 modulates lipid raft organization and oxLDL internalization, acting as a pro-inflammatory mediator in foam cell biology. These findings highlight Gal-3 as a potential therapeutic target for early atherosclerosis.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"57 2","pages":"Article 103300"},"PeriodicalIF":3.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145027431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of Gestational Diabetes Mellitus in Mexico from 2008 to 2023","authors":"Niels H. Wacher ,&nbsp;Rita A. Gómez-Díaz ,&nbsp;Ivan De Jesús Ascencio-Montiel ,&nbsp;José Esteban Fernández-Garate ,&nbsp;Leticia A. Valdez-González ,&nbsp;Claudio Quinzaños Fresnedo","doi":"10.1016/j.arcmed.2025.103288","DOIUrl":"10.1016/j.arcmed.2025.103288","url":null,"abstract":"<div><h3>Aim</h3><div>To describe the annual incidence of gestational diabetes mellitus (GDM) among women beneficiaries of the Mexican Institute of Social Security (IMSS) in Mexico from 2008 to 2023.</div></div><div><h3>Methods</h3><div>Data from the IMSS’s Institutional Automated System for Epidemiological Surveillance (SIAVE) from 2008 to 2023 were used. GDM cases during pregnancy were identified using ICD-10 O24.4 diagnostic codes. Changes in annual incidence were evaluated using the Join-Point program version 5.1.0 to calculate the annual percentage change (APC) and the average annual percentage change (AAPC).</div></div><div><h3>Results</h3><div>A total of 103,749 cases of diabetes during pregnancy were recorded and the annual incidence rate of GDM increased over the time. The incidence of GDM peaked in 2021 among those 19 years old or younger, and in 2022 among those 20 years old or older, with a higher incidence in the latter group. There was a considerably higher incidence of GDM in the North region compared to the other regions. The estimated AAPC for the 2008–2023 period was 21.1 (16.8–25.6) per 1000 live births, and was higher in the West region.</div></div><div><h3>Conclusions</h3><div>This study demonstrates a nationwide substantial upward trend in GDM incidence between 2008 and 2023. Both teenage and adult women reported a higher incidence in recent years (2021 and 2022, respectively). The North region had the highest incidence, while the West had the highest AAPC.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"57 2","pages":"Article 103288"},"PeriodicalIF":3.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144989555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal Phthalate Exposure Alters Prostate Proteome in Rat Offspring: Linking Omics Insights to Prostate Cancer Risk in Humans","authors":"Patrick Vieira Souza ,&nbsp;Ariana Musa Aquino ,&nbsp;Luiz Guilherme Alonso-Costa ,&nbsp;Natália Magosso ,&nbsp;Marcos Antonio Fernandes de Oliveira ,&nbsp;Vanessa Aguiar Rocha ,&nbsp;Matheus Naia Fioretto ,&nbsp;Mirella Franco Moreira ,&nbsp;Victória Cristina Pinha ,&nbsp;Gabriel Henrique Caxali ,&nbsp;Luis Antônio Justulin ,&nbsp;Jodi Anne Flaws ,&nbsp;Wellerson Rodrigo Scarano","doi":"10.1016/j.arcmed.2025.103297","DOIUrl":"10.1016/j.arcmed.2025.103297","url":null,"abstract":"<div><h3>Background</h3><div>Phthalates are compounds used as plasticizers to increase the flexibility of plastics and are considered endocrine disruptors. Some studies suggest that the origin of prostate cancer (PCa) may be associated with disturbances during embryo-fetal development. Previous data showed that perinatal exposure to the same phthalate mixture (PM) used here increased the incidence of adenocarcinomas in the prostates of aged rats. Building on our earlier work, this study identifies proteins altered in the prostate proteome by exposure to a PM during gestation and lactation in rats, focusing on proteins in the human secretome and their correlation with PCa.</div></div><div><h3>Methods</h3><div>Pregnant SD rats were divided into three groups and treated from gestational day (GD)10 to postnatal day (PND)21. On PND22 the differentially abundant proteins in the offspring’s prostate were compared with the predicted secreted proteins in humans. Then, the abundance of selected proteins was compared among groups and enriched. Finally, a protein-protein interaction network was obtained. The resulting data were cross-referenced with data for PCa and some targets were validated by RT-qPCR and Western blot.</div></div><div><h3>Results</h3><div>Perinatal exposure to PM affected the endoplasmic reticulum, decreasing the amount of certain proteins crucial for protein folding and secretion, impairing secretion of several proteins important for proper prostate development. Furthermore, <em>in silico</em> analysis revealed that several proteins in the rat proteome are also altered in patients with PCa.</div></div><div><h3>Conclusions</h3><div>Our results suggest that early exposure to phthalates may modulate protein secretion, creating a microenvironment that impairs tissue development and increases susceptibility to oncogenesis.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"57 2","pages":"Article 103297"},"PeriodicalIF":3.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145011099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal Autonomic and Adrenocorticotropic Features in the Offspring of Mothers With Gestational Diabetes","authors":"Sebastiano Ravenda ,&nbsp;Virginia Beretta ,&nbsp;Elena Scarpa ,&nbsp;Chiara Petrolini ,&nbsp;Valentina Dell’Orto ,&nbsp;Luca Carnevali ,&nbsp;Andrea Sgoifo ,&nbsp;Serafina Perrone","doi":"10.1016/j.arcmed.2025.103293","DOIUrl":"10.1016/j.arcmed.2025.103293","url":null,"abstract":"<div><h3>Background</h3><div>Gestational diabetes mellitus (GDM) affects intrauterine glucose regulation and influences heart rate variability (HRV) and cortisol levels in newborns, which are markers of autonomic and hypothalamic-pituitary-adrenal axis function. This study aimed to evaluate HRV and cortisol levels in newborns of healthy mothers and those with GDM within the first 24 h of life, and to compare these measures between sexes.</div></div><div><h3>Methods</h3><div>A total of 59 newborns were monitored for heart rate (HR) and HRV from the 6 h of life. Salivary cortisol levels were measured 3–6 h (T1) and 20–24 h (T2) after birth. HRV parameters included the root mean square of successive differences (RMSSD), the high (HF) and low (LF) band power of HRV, and the LF/HF ratio.</div></div><div><h3>Results</h3><div>GDM newborns showed lower HR, higher RMSSD, and a lower LF/HF ratio compared to controls. GDM females had lower HR than control females and GDM males, while GDM males had higher RMSSD and HF than control males. Cortisol levels decreased from T1–T2 in both groups with no sex differences.</div></div><div><h3>Conclusions</h3><div>Newborns from mothers with GDM exhibited lower HR and higher cardiac vagal modulation, with sex-specific differences. GDM females showed a decrease in HR without changes in HRV, whereas GDM males showed an increase in vagally mediated HRV without changes in HR. GDM does not seem to affect cortisol levels in newborns. These findings highlight sex-specific cardiac autonomic responses to birth stress in GDM-exposed newborns across the first day of life, which play an important role in shaping different behavioral, resilience, and well-being trajectories in early infancy.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"57 2","pages":"Article 103293"},"PeriodicalIF":3.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144989549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Agility and Resilience During COVID-19 and Post-Pandemic Innovation in Brazilian Public University Hospitals","authors":"Juliana Pascualote Lemos de Almeida ,&nbsp;Marina Figueiredo Moreira ,&nbsp;David Nadler Prata ,&nbsp;Paulo Henrique de Souza Bermejo","doi":"10.1016/j.arcmed.2025.103294","DOIUrl":"10.1016/j.arcmed.2025.103294","url":null,"abstract":"<div><h3>Background</h3><div>The COVID-19 pandemic prompted rapid adaptations in healthcare systems worldwide. Academic medical centers, pivotal in healthcare education and research, rapidly adopted innovations. Brazilian state-owned university hospitals experienced unprecedented pressure on their services and were compelled to adopt new approaches to education and care delivery.</div></div><div><h3>Aims</h3><div>Analyze the organizational agility and resilience of two Brazilian federal university hospitals during the pandemic. Identify crisis-driven innovations and propose a quantitative indicator framework to measure agility, resilience, and the embedding of innovations post-crisis.</div></div><div><h3>Methods</h3><div>We conducted a document analysis of the COVID-19 contingency plans, managerial reports and news items from the two hospitals, both managed by the Brazilian Hospital Services Company. Actions were inductively coded and synthesized into measurable indicators.</div></div><div><h3>Results</h3><div>The hospitals implemented tactical and operational adjustments, relocated resources, and improved patient care strategies. Telemedicine and strategic patient transfers empowered users during critical phases. Virtual care technologies promoted self-care and improved treatment efficacy, while staff well-being programs supported clinical teams. We present an indicator framework comprising 26 metrics, organized into pandemic-phase (agility and resilience) and post-COVID (innovation) blocks.</div></div><div><h3>Conclusions</h3><div>The contingency plans demonstrate strong organizational agility and resilience. The proposed framework offers a practical toolkit for benchmarking crisis readiness and tracking the institutionalization of pandemic-era innovations, thereby supporting Brazil’s universal healthcare system and guiding future research.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"57 2","pages":"Article 103294"},"PeriodicalIF":3.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144989557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammation in Pregnancy: Key Drivers, Signaling Pathways and Associated Complications","authors":"Abigail García-Morales ,&nbsp;Consuelo Lomas-Soria ,&nbsp;Gabriela Granados-Higa ,&nbsp;Janice García-Quiroz ,&nbsp;Euclides Avila ,&nbsp;Andrea Olmos-Ortiz ,&nbsp;Lorenza Díaz","doi":"10.1016/j.arcmed.2025.103301","DOIUrl":"10.1016/j.arcmed.2025.103301","url":null,"abstract":"<div><div>In the developmental origins of health and disease (DOHaD) paradigm, there is a clear link between an adverse prenatal environment and the development of non-hereditary diseases later in life. Exposure to intrauterine inflammation, for example, has been associated with several late-onset conditions, including neurological, cardiovascular, immune, and metabolic disorders. Moreover, maternal and fetal health are compromised under exacerbated inflammation, as it can result in spontaneous abortion, preterm delivery, or intrauterine growth restriction. Prominent gestational pathologies associated with inflammation include preeclampsia, gestational diabetes mellitus, obesity, and infections. The main causes of inflammation can be classified as either infectious or sterile in origin. Thus, triggers of inflammation include microorganisms, viruses, excess fat, placental dysfunction, tissue breakdown products, and unbalanced immunoendocrine factors. Other etiological agents of inflammation include environmental factors (e.g., pollutants), lifestyle factors (e.g., nutrient overload), and behavioral factors (e.g., chronic stress, smoking, alcohol, and drug abuse). The mediators that drive the response to these insults include biochemical effectors (e.g., cytokines), pattern recognition receptors (e.g., toll-like receptors), and immune cells. These trigger a cascade of events leading to the activation of specific nuclear factors such as NF-kB and STATs. Overactivation of these signaling networks can disrupt the homeostasis at the feto-maternal interface, which can jeopardize pregnancy maintenance and influence fetal programming mechanisms. This review examines the key triggers, signaling pathways, and complications associated with inflammation during pregnancy, emphasizing the importance of maternal well-being and adequate prenatal care in mitigating and preventing inflammation-related risks in the short and long term.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"57 2","pages":"Article 103301"},"PeriodicalIF":3.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144989655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First 1,000 Days of Life Have a Direct Impact on Health: A Mexican Strategy","authors":"Victoria Ramirez ,&nbsp;Itzel Kim ,&nbsp;Regina J. Bautista ,&nbsp;Claudia J. Bautista","doi":"10.1016/j.arcmed.2025.103369","DOIUrl":"10.1016/j.arcmed.2025.103369","url":null,"abstract":"<div><div>Chronic non-communicable degenerative diseases are the leading cause of mortality, morbidity, and disability in Mexico and worldwide, negatively impacting national economies by consuming health and social resources. These diseases include hypertension, obesity, and cardiovascular diseases resulting from inadequate dietary conditions and current lifestyles. It is undeniable that nutrition and healthy habits are prerequisites for a healthy life. However, the significance of nutrition and health habits is amplified during the initial 1,000 days of life, when an individual is unable to select their food or environment. This is due to the fact that this is a period of organ and system development, when the body is particularly vulnerable to inadequate nutrition and a toxic environment, especially during pregnancy. The present review has two objectives. First, it aims to describe the importance of maintaining a healthy, balanced diet from conception through the first two years of life. Second, it will explore current Mexican nutritional recommendations, public strategies, and innovations to improve in each stage of development. This review will also help formulate targeted health strategies for this population, fostering the comprehensive approach essential for establishing lifelong healthy habits with long-term benefits for children, adolescents, and adults.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"57 2","pages":"Article 103369"},"PeriodicalIF":3.4,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146013757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}