Archives of Medical Research最新文献

{"title":"Impact on Fatality Rates and Years of Life Lost During the COVID-19 Pandemic: The Experience of the Mexican Public Health Incident Management Command","authors":"Célida Duque-Molina ,&nbsp;Gabriel García-Rodríguez ,&nbsp;Christian Arturo Zaragoza-Jiménez ,&nbsp;Alethse de la Torre-Rosas ,&nbsp;Michelle Herrera-Canales ,&nbsp;Miriam Jackeline Loera-Rosales ,&nbsp;Ana Luisa Pérez-Cardoso ,&nbsp;Tania Villa-Reyes ,&nbsp;Rubí Romo-Rodríguez ,&nbsp;Sofhya Marylett Sánchez-Morales ,&nbsp;Iris Contreras-Hernández ,&nbsp;Rodolfo Rivas-Ruiz ,&nbsp;Octavio Castro-Escamilla ,&nbsp;Eduardo Ferat-Osorio ,&nbsp;Antonio J. Berlanga-Taylor ,&nbsp;Rosana Pelayo ,&nbsp;Laura C. Bonifaz ,&nbsp;Zoe Robledo-Aburto ,&nbsp;Jorge Alcocer-Varela","doi":"10.1016/j.arcmed.2024.103073","DOIUrl":"10.1016/j.arcmed.2024.103073","url":null,"abstract":"<div><h3>Background</h3><p>The SARS-CoV-2 pandemic challenged health systems worldwide. In Mexico, the Public Health Incident Management Command (COISS) strategy was implemented to improve health care for patients with COVID-19 who required hospitalization.</p></div><div><h3>Aim</h3><p>To evaluate the impact of the COISS strategy on case fatality rates (CFR) and years of life lost (YLL) in hospitalized patients with COVID-19.</p></div><div><h3>Materials and Methods</h3><p>The COISS strategy included eight actions implemented in states with high epidemic risk (COISS states). A secondary analysis of the public database from the Mexican Ministry of Health was performed considering patients with confirmed diagnoses of SARS-CoV-2 infection. The COISS strategy effectiveness was evaluated by its impact on in-hospital CFR and YLL at the beginning (T0) and end (T1) of the third wave, and at the end of the fourth wave (T2) and compared to states without intervention (non-COISS states).</p></div><div><h3>Results</h3><p>At T0, COISS states showed a higher CFR for hospitalized patients than non-COISS states, which decreased after the strategy implementation. After correction for baseline conditions, lower relative CFR at T1 and T2, compared to T0, and a protective effect in different age groups, especially in those ≥65 years, were found in hospitalized patients in COISS states. The COISS strategy was associated with lower CFR in hospitalized patients with COVID-19 at both T1 and T2. At T0, YLLs were higher in COISS states, but there were no significant differences at T1 and T2.</p></div><div><h3>Conclusions</h3><p>COISS interventions effectively reduced CFR in hospitalized patients with COVID-19, providing protection to vulnerable patients and reducing the YLL gap.</p></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 1","pages":"Article 103073"},"PeriodicalIF":4.7,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0188440924001255/pdfft?md5=41309efeadb3c41a7dd3f684e8de839b&pid=1-s2.0-S0188440924001255-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142162893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteoporosis and Fragility Fractures in Mexico: A Call to Action","authors":"Patricia Clark ,&nbsp;Monica Caló ,&nbsp;José Francisco Torres-Naranjo ,&nbsp;Federico Cisneros-Dreinhofer ,&nbsp;Luis Humberto Silveira-Torre ,&nbsp;Mónica Tapia-Hernández ,&nbsp;Juan Humberto Medina-Chávez ,&nbsp;Luis Miguel Gutiérrez-Robledo ,&nbsp;Alfredo Adolfo Reza-Albarrán ,&nbsp;Roberto Coronado-Zarco ,&nbsp;Andrea Olascoaga-Gómez de León ,&nbsp;Ma. de los Ángeles Soria-Bastida ,&nbsp;Melissa M. Islas-Upegui ,&nbsp;Edgar Saúl Tejeda-Chávez ,&nbsp;Roberto Enrique López-Cervantes ,&nbsp;Blanca Luz Jiménez-Herrera","doi":"10.1016/j.arcmed.2024.103062","DOIUrl":"10.1016/j.arcmed.2024.103062","url":null,"abstract":"<div><p>Osteoporosis (OP) is a chronic disease that affects older adults’ quality of life, with fragility fractures (FF) being its most significant consequence due to their impact on healthcare systems in terms of morbidity, and economic and caregiving burden. FF are defined as fractures resulting from low-energy trauma, defined as falls from a standing height or less, and are usually considered osteoporotic <span><span>(1)</span></span>. World demographic projections warn of a significant increase in adults aged 65 and older by 2050. These demographic changes mean that OP and FF will soon become an even greater challenge for healthcare systems, where prevention programs should be a priority.</p><p>In Mexico, FF is also a public health challenge, with an initial reported incidence of nearly 2,000 cases per 100,000 population, and a projected seven-fold increase by 2050. Given this scenario, there is an urgent need for policy- and decision-makers to change their approach and formulate health policies that guarantee that people aged 65 and older are screened for fractures and have access to appropriate care. These policies should be part of a strategy to minimize FF and ensure active and healthy aging according to the WHO's Decade of Healthy Ageing.</p><p>In this context, a group of Mexican experts representing different health organizations interested in the burden of OP and FF met to discuss possible strategies to reduce their burden for the next decade and summarize them in this Call to Action to promote public policies that prioritize an evidence-based approach to the prevention and treatment of OP and FF.</p></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"55 7","pages":"Article 103062"},"PeriodicalIF":4.7,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0188440924001140/pdfft?md5=83d16ce61227d8e8609fdc7c3e734cf4&pid=1-s2.0-S0188440924001140-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142163055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence of Browning and Inflammation Features in Visceral Adipose Tissue of Women with Endometriosis","authors":"José Pedro Abobeleira ,&nbsp;Ana Catarina Neto ,&nbsp;Jan Mauersberger ,&nbsp;Maria Salazar ,&nbsp;Maria Botelho ,&nbsp;Ana Sofia Fernandes ,&nbsp;Margarida Martinho ,&nbsp;Maria Paula Serrão ,&nbsp;Adriana Raquel Rodrigues ,&nbsp;Henrique Almeida ,&nbsp;Alexandra Maria Gouveia ,&nbsp;Delminda Neves","doi":"10.1016/j.arcmed.2024.103064","DOIUrl":"10.1016/j.arcmed.2024.103064","url":null,"abstract":"<div><h3>Background</h3><p>Patients with endometriosis tend to have a low body mass index, suggesting an inverse relationship between body fat and risk of disease. This is supported by evidence that miRNAs differentially expressed in endometriosis induce browning of pre-adipocytes <em>in vitro</em>. Thus, we hypothesize that endometriosis may underlie adipose tissue (AT) dysfunction and browning.</p></div><div><h3>Aims</h3><p>Identify inflammation and browning processes in AT collected from endometriosis patients.</p></div><div><h3>Methods</h3><p>Visceral and subcutaneous AT samples were obtained during endometriosis (<em>n</em> = 32) or uterine myoma (<em>n</em> = 14; controls) surgery. Blood catecholamines were determined by high-performance liquid chromatography while IL-6 and TGF-β levels were quantified by ELISA. Adipocyte cross-sectional areas were analyzed in H&amp;E-stained sections by computer-assisted morphometry. Macrophages (F4/80; Galectin-3) and browning activation (UCP-1; PGC-1α) in tissues were identified by dual label immunofluorescence. Expression of inflammatory (IL-6; MCP-1; Galectin-3; CD206; TIMP1; TGF-β) and browning-related (UCP-1; PGC-1α; DIO2; CITED1; CIDEA; TMEM26; TBX1; PRDM16; PPAR-γ) molecules in AT were assessed by RT-PCR and Western blotting.</p></div><div><h3>Results</h3><p>Compared to controls, patients presented smaller adipocytes, especially in VAT, and lower norepinephrine levels. Serum IL-6, but not TGF-β, was increased in patients. UCP-1, PGC-1α, IL-6, and MCP-1 were upregulated in VAT from endometriosis women, which also evidenced a reduction of CD206, relative to controls. However, no differences were found in mRNA expression of IL-6, TIMP1, and TGF-β nor Galectin-3 protein levels. In SAT, protein expression remained unchanged between patients and controls.</p></div><div><h3>Conclusions</h3><p>Our findings support an endometriosis’ role as a pro-catabolic state along with local signals of VAT browning and inflammation.</p></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"55 7","pages":"Article 103064"},"PeriodicalIF":4.7,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0188440924001164/pdfft?md5=10a231b6e130f16b45d1a5c475a89f14&pid=1-s2.0-S0188440924001164-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142150373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Prevalence and Potential Impact of HPV Vaccines in Patients with and Without Oral Diseases: A Ten-Year Retrospective Study","authors":"Michela Buttà ,&nbsp;Nicola Serra ,&nbsp;Erika Mannino ,&nbsp;Vera Panzarella ,&nbsp;Daniela Cabibi ,&nbsp;Giuseppina Campisi ,&nbsp;Daniela Pistoia ,&nbsp;Giuseppina Capra","doi":"10.1016/j.arcmed.2024.103059","DOIUrl":"10.1016/j.arcmed.2024.103059","url":null,"abstract":"<div><h3>Background</h3><p>The prevalence of oral human papillomavirus (HPV) in the healthy population and patients with oral diseases such as oral squamous cell carcinoma (OSCC), oral potentially malignant disorders (OPMDs), and oral benign lesions (BL), is not consistently described in the literature, with scarce and often heterogeneous data. In addition, the efficacy of HPV prophylactic vaccines in preventing HPV-related oral disorders has been scarcely investigated.</p></div><div><h3>Methods</h3><p>The prevalence of HPV and the potential impact of vaccines were analyzed in 1,415 oral rinse specimens, collected over 10 years and grouped into four categories based on histological/clinical diagnosis.</p></div><div><h3>Results</h3><p>HPV prevalence in OSCC, OPMD, and BL patients and in healthy individuals potentially exposed to HPV (HPE) was comparable (12.7 vs. 27.2% vs. 13.5 vs. 9%). Statistical analysis of the vaccine impact involved calculating high and low estimates and showed a significant difference only for the low effect. The nonavalent vaccine had higher low estimates than the bivalent vaccine in OSCC and HPE patients (29.6 vs. 51.9%, <em>p</em> &lt; 0.05; 18.2 vs. 42.4%, <em>p</em> &lt; 0.05), while for OPMD and BL, the frequency of bivalent low estimates was lower than that of quadrivalent and nonavalent (48.6 vs. 68.6%, <em>p</em> &lt; 0.05 and 48.6 vs. 77.1%, <em>p</em> &lt; 0.05; 23.9 vs. 50.7%, <em>p</em> &lt; 0.05, and 23.9 vs. 63.4%, <em>p</em> &lt; 0.05).</p></div><div><h3>Conclusions</h3><p>This study provided new insights into the prevalence of oral HPV and showed that the nonavalent vaccine may provide better protection than the other vaccines in the presence of an OSCC diagnosis. Conversely, the quadrivalent vaccine may be sufficient to prevent OPMD and BL.</p></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"55 7","pages":"Article 103059"},"PeriodicalIF":4.7,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0188440924001115/pdfft?md5=724d759997e58d4ca45656042270244b&pid=1-s2.0-S0188440924001115-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142147062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strengthening healthcare systems in Latin America. Post-pandemic efforts","authors":"Osvaldo Artaza Barrios ,&nbsp;Ricardo Pérez-Cuevas","doi":"10.1016/j.arcmed.2024.103070","DOIUrl":"10.1016/j.arcmed.2024.103070","url":null,"abstract":"","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"55 7","pages":"Article 103070"},"PeriodicalIF":4.7,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142147063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Which side of the coin are you on regarding possible postnatal oogenesis?","authors":"Elizabeth Morales-Sánchez ,&nbsp;Juan Carlos Campuzano-Caballero ,&nbsp;Alicia Cervantes ,&nbsp;Alejandra Martínez-Ibarra ,&nbsp;Marco Cerbón ,&nbsp;Víctor S. Vital-Reyes","doi":"10.1016/j.arcmed.2024.103071","DOIUrl":"10.1016/j.arcmed.2024.103071","url":null,"abstract":"<div><p>It is well known that oocytes are produced during fetal development and that the total number of primary follicles is determined at birth. In humans, there is a constant loss of follicles after birth until about two years of age. The number of follicles is preserved until the resumption of meiosis at puberty and there is no renewal of the oocytes; this dogma was maintained in the last century because there were no suitable techniques to detect and obtain stem cells. However, following stem cell markers, several scientists have detected them in developing and adult human ovarian tissues, especially in the ovarian surface epithelial cells. Furthermore, many authors using different methodological strategies have indicated this possibility. This evidence has led many scientists to explore this hypothesis; there is no definitive consensus to accept this idea. Interestingly, oocyte retrieval from mature ovaries and other tissue sources of stem cells has contributed to the development of strategies for the retrieval of mature oocytes, useful for assisted reproductive technology. Here, we review the evidence and controversies on oocyte neooogenesis in adult women; in addition, we agree with the idea that this process may occur in adulthood and that its alteration may be related to various pathologies in women, such as polycystic ovary syndrome, premature ovarian insufficiency, diminished ovarian reserve and several infertility and genetic disorders.</p></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"55 8","pages":"Article 103071"},"PeriodicalIF":4.7,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142137188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative Transcriptomic Analysis of Peripheral Blood Monocytes in Systemic Sclerosis and Shared Pathogenic Pathways in Autoimmune Diseases","authors":"Shaoqi Chen ,&nbsp;Yu Fan ,&nbsp;Qiulin Wu ,&nbsp;Guohong Zhang ,&nbsp;Yukai Wang ,&nbsp;Weiping Li ,&nbsp;Shengli Yang ,&nbsp;Marco Matucci-Cerinic ,&nbsp;Daniel E. Furst","doi":"10.1016/j.arcmed.2024.103072","DOIUrl":"10.1016/j.arcmed.2024.103072","url":null,"abstract":"<div><h3>Background</h3><p>Systemic sclerosis (SSc) is an autoimmune disease (AD), that receives less attention compared to rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and primary Sjögren's syndrome (pSS). This study aims to analyze transcriptional profiles and immune cell composition in peripheral blood mononuclear cells (PBMC) from SSc patients compared to other ADs.</p></div><div><h3>Methods</h3><p>RNA-seq data from 119 untreated patients (eight with SSc, 42 with RA, 41 with pSS, 28 with SLE) and 20 healthy controls were analyzed. Bioinformatics tools were employed to identify differentially expressed genes (DEGs), biological functions and immune cell profiles unique to SSc and shared with other ADs.</p></div><div><h3>Results</h3><p>1,148 DEGs were found in SSc, with upregulated genes associated with megakaryocyte processes and downregulated genes associated with neutrophil function and immune response.</p><p>DEGs, including <em>ALDH1A1</em> and <em>MEGF9</em>, were associated with neutropenia. Upregulated transcription factors (TFs) were linked to embryonic hematopoiesis and downregulated TFs were involved in leukocyte differentiation and immune regulation. Comparative analysis with other ADs revealed common pathogenic pathways, emphasizing megakaryocyte proliferation. Neutrophils count was significantly decreased in ADs (<em>p</em> &lt; 0.001) compared to healthy controls. Comparative analysis highlighted common pathways, particularly in megakaryocyte proliferation, and unique genes (<em>MEGF9, MMP8,</em> and KRT family members) in SSc, suggesting roles in neutrophil function, skin integrity, and fibrosis.</p></div><div><h3>Conclusions</h3><p>This study identifies dysregulated gene expression (KRT and <em>MMP8</em>) associated with neutrophil function and increased megakaryocytes in SSc, highlighting common patterns across autoimmune diseases. These findings offer new insights into the potential pathogenesis of SSc, and help to explore new targets for the treatment.</p></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 1","pages":"Article 103072"},"PeriodicalIF":4.7,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0188440924001243/pdfft?md5=0e2feb787f7209026a7fab5283e4b045&pid=1-s2.0-S0188440924001243-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142087404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Making and Selecting the Best Embryo in In vitro Fertilization","authors":"Rocío Nuñez-Calonge ,&nbsp;Nuria Santamaria ,&nbsp;Teresa Rubio ,&nbsp;Juan Manuel Moreno","doi":"10.1016/j.arcmed.2024.103068","DOIUrl":"10.1016/j.arcmed.2024.103068","url":null,"abstract":"<div><p>Currently, most assisted reproduction units transfer a single embryo to avoid multiple pregnancies. Embryologists must select the embryo to be transferred from a cohort produced by a couple during a cycle. This selection process should be accurate, non-invasive, inexpensive, reproducible, and available to <em>in vitro</em> fertilization (IVF) laboratories worldwide.</p><p>Embryo selection has evolved from static and morphological criteria to the use of morphokinetic embryonic characteristics using time-lapse systems and artificial intelligence, as well as the genetic study of embryos, both invasive with preimplantation genetic testing for aneuploidies (PGT-A) and non-invasive (niPGT-A). However, despite these advances in embryo selection methods, the overall success rate of IVF techniques remains between 25 and 30%. This review summarizes the different methods and evolution of embryo selection, their strengths and limitations, as well as future technologies that can improve patient outcomes in the shortest possible time. These methodologies are based on procedures that are applied at different stages of embryo development, from the oocyte to the cleavage and blastocyst stages, and can be used in laboratory routine.</p></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"55 8","pages":"Article 103068"},"PeriodicalIF":4.7,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142076317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Veiled Menace: The Contribution of Pollution to Endocrine Diseases","authors":"YASHENDRA SETHI ,&nbsp;SAMEER MEHTA ,&nbsp;NIRJA KAKA ,&nbsp;NEIL PATEL ,&nbsp;NIDHI UNIYAL","doi":"10.1016/j.arcmed.2024.103067","DOIUrl":"10.1016/j.arcmed.2024.103067","url":null,"abstract":"","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 1","pages":"Article 103067"},"PeriodicalIF":4.7,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142077464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Air Pollution on Neurological and Psychiatric Health","authors":"YASHENDRA SETHI,&nbsp;PRATIK AGARWAL,&nbsp;VIDHI VORA,&nbsp;SIDDHARTH GOSAVI","doi":"10.1016/j.arcmed.2024.103063","DOIUrl":"10.1016/j.arcmed.2024.103063","url":null,"abstract":"<div><p>Air pollution is a critical global issue with extensive implications beyond respiratory health, significantly affecting neurological and psychiatric disorders. Emerging evidence establishes a link between exposure to fine particulate matter (PM &lt; 2.5 µm), sulfur dioxide (SO₂), and nitrogen dioxide (NO₂) and heightened risks of dementia, Alzheimer's disease, schizophrenia, ADHD, stroke, Parkinson's disease, and multiple sclerosis. Mechanistic pathways include neuroinflammation, oxidative stress, microglial activation, cerebrovascular dysfunction, and blood-brain barrier disruption. Epidemiological studies indicate increased susceptibility among urban residents, particularly men, middle-aged individuals, and married persons, to the mental health impacts of air pollution. Additionally, socioeconomic factors, such as GDP per capita, access to health resources, green spaces, and sports facilities, modulate these health outcomes. Addressing this public health challenge necessitates stricter industrial emission controls, sustainable agricultural practices, promotion of cleaner energy sources, and incorporation of pollution exposure history into clinical assessments. Enhanced public awareness and interdisciplinary research are vital for mitigating the detrimental effects of air pollution on neurological and psychiatric health, ultimately striving for a cleaner and healthier environment for future generations.</p></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"55 7","pages":"Article 103063"},"PeriodicalIF":4.7,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141903914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}