Archives of Medical Research最新文献

{"title":"Clinical and Laboratorial Evaluation of Male Infertility. A Detailed Practical Approach","authors":"Lucas G. Fraga ,&nbsp;João PM. Gismondi ,&nbsp;Lucas V. Sanvido ,&nbsp;Ana Flávia Q. Lozano ,&nbsp;Thiago A. Teixeira ,&nbsp;Jorge Hallak","doi":"10.1016/j.arcmed.2024.103139","DOIUrl":"10.1016/j.arcmed.2024.103139","url":null,"abstract":"<div><div>Infertility, defined as the inability to achieve pregnancy after one year of unprotected, frequent sexual intercourse, is a global burden that affects approximately 15% of couples, or 190–230 million people worldwide, who are trying to start a family. The male contributes significantly, directly accounting for 30–35% and up to 52% of total couple infertility, affecting approximately 7–8% of all men. This work aims to present, in a didactic and objective way, a standardization of the initial steps toward a thorough evaluation of subfertile and infertile men. We have focused on the evaluation of initial management, emphasizing the need for a comprehensive evaluation that includes a detailed history, physical examination, and semen analysis as the golden triple helix of basic evaluation of the infertile male. General and genital physical examinations are highly valuable due to the wealth of information they provide, from potential diagnoses to pregnancy prognoses. Comprehensive and quality-controlled semen analysis provides reliable information as a baseline test to evaluate the patency of the reproductive tract and to evaluate basic sperm parameters and fertility potential. However, it is not a fertility determinant and should preferentially be complemented with sperm functional tests. like biomarkers of oxidative stress, sperm immaturity and DNA fragmentation. Most cases of infertility require evaluation by a specialist in andrology, nonetheless the understanding and rationale of the initial assessment of the infertile male can be undertaken by non-specialists, thus improving the care and counseling of couples facing this troubling issue and avoiding unnecessary use of assisted reproductive technologies (ART) since most cases of male infertility can be treated and reversed by medical or surgical interventions, and the fertility status can be restored. The ultimate goal is to achieve natural pregnancy, the use of ART should not be the initial offered resource.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"55 8","pages":"Article 103139"},"PeriodicalIF":4.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reproductive medicine: The future is now","authors":"Sergio Papier ,&nbsp;Fiamma Di Biase ,&nbsp;Julieta Quaglia","doi":"10.1016/j.arcmed.2024.103138","DOIUrl":"10.1016/j.arcmed.2024.103138","url":null,"abstract":"","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"55 8","pages":"Article 103138"},"PeriodicalIF":4.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developmental outcomes of very preterm infants conceived through in vitro fertilization","authors":"Taylor Badger ,&nbsp;Emma Johns ,&nbsp;Teresa Wilson ,&nbsp;Kathleen Groesch ,&nbsp;Paula Diaz-Sylvester ,&nbsp;Erin Bauer ,&nbsp;Albert Botchway ,&nbsp;Melanie Nielsen ,&nbsp;Julio Ricardo Loret de Mola ,&nbsp;Beau Batton","doi":"10.1016/j.arcmed.2024.103136","DOIUrl":"10.1016/j.arcmed.2024.103136","url":null,"abstract":"<div><h3>Objective</h3><div>To compare in-hospital and neurodevelopmental (ND) outcomes between very preterm infants conceived spontaneously and those conceived utilizing <em>in vitro</em> fertilization (IVF).</div></div><div><h3>Study Design</h3><div>A 10-year retrospective study of a large regional, mixed urban and rural population was conducted. IVF conceived infants born &lt;32 0/7 weeks gestational age (GA) were matched 1:2 to control patients who did not undergo any documented assisted reproductive technology (ART) based on GA, birth weight and gender. In-hospital and ND data were analyzed.</div></div><div><h3>Results</h3><div>There were 35,712 live births, including 755 (2.1%) IVF-conceived births (519 [68.7%] full term, 236 [31.3%] preterm, 33 born &lt;32 0/7 weeks GA [14.0%] – including 27 cared for in the HSHS St. John's Hospital NICU with long-term ND data). When compared to 54 controls, these 27 very preterm IVF-conceived infants were more likely to be born to older women (OR 1.21 [1.07–1.35], <em>p</em> = 0.001), but other demographic data (i.e., including primigravida status, length of hospital stay, use of antenatal corticosteroids, mode of delivery, rural residency, etc.) were similar. Compared to other very preterm neonates, IVF conceived very preterm infants were less likely to receive surfactant therapy (9 [33%] vs. 34 [63%], <em>p</em> = 0.104). Other in-hospital outcomes were similar. Data for ND outcomes through 24 months (non-matched data due to loss to follow-up) were also similar between cohorts.</div></div><div><h3>Conclusion</h3><div>Infants born very preterm after IVF conception have similar in-hospital and ND outcomes when compared to other very preterm infants. This is reassuring information that can be shared with individuals considering IVF conception.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"55 8","pages":"Article 103136"},"PeriodicalIF":4.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics and outcomes of infective endocarditis in patients with cancer: A multicenter case-control study","authors":"Gustavo Mendez-Hirata ,&nbsp;Frida Rivera-Buendía ,&nbsp;Eduardo Viveros-Rentería ,&nbsp;Eric Ochoa-Hein ,&nbsp;Patricia Cornejo-Juárez ,&nbsp;Manlio Márquez ,&nbsp;José Ramón Hidalgo-Dura ,&nbsp;Yoana Leyva-López ,&nbsp;Diana Vilar-Compte","doi":"10.1016/j.arcmed.2024.103123","DOIUrl":"10.1016/j.arcmed.2024.103123","url":null,"abstract":"<div><h3>Background</h3><div>Due to increased exposure to health hazards, patients with cancer are at a higher risk of developing infective endocarditis (IE), which in turn maximizes their risk of poor outcomes. This study aimed to analyze IE events in patients with cancer and matched controls.</div></div><div><h3>Methods</h3><div>We conducted a retrospective case-control study in four third-level centers in Mexico City between 2006 and 2022. Patients with IE were identified; cases (patients with cancer) were matched in a 1:2 ratio with controls (patients without cancer). Baseline characteristics, factors associated with IE, and outcomes were assessed in both groups.</div></div><div><h3>Results</h3><div>A total of 108 patients were included (36 cases and 72 controls). After logistic regression analysis, the risk factors independently associated with IE in cases were obesity (adjusted odds ratio [aOR] 9.03, 95 % CI 1.5–51.8), surgery within six months before IE (aOR 6.23, 95 % CI 1.8–21.5), and invasive procedures within six months prior to IE (aOR 3.89, 95 % CI 1.15–13.1). Healthcare-associated IE was more common in these cases, as were systemic embolic episodes. Subjects with <em>S. aureus</em> IE were more prone to experience systemic embolization. There were no differences in mortality between the groups.</div></div><div><h3>Conclusion</h3><div>In this study, risk factors associated with the healthcare environment were more frequent in patients with IE and cancer. <em>S. aureus</em> was a common culprit and was associated with systemic embolization.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 3","pages":"Article 103123"},"PeriodicalIF":4.7,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142744274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 in Venezuela: Costs and challenges of management severe cases at home in a crisis setting","authors":"David A. Forero-Peña ,&nbsp;Fhabián S. Carrión-Nessi ,&nbsp;Óscar D. Omaña-Ávila ,&nbsp;Daniela L. Mendoza-Millán ,&nbsp;Augusto Moncada-Ortega ,&nbsp;María E. Landaeta","doi":"10.1016/j.arcmed.2024.103126","DOIUrl":"10.1016/j.arcmed.2024.103126","url":null,"abstract":"<div><div>The humanitarian crisis in Venezuela has become an unprecedented regional emergency. Over the past decade, Venezuela's political and economic collapse has eroded the country's healthcare infrastructure and threatened the public health of the population. Shortages of medicines and health supplies, disruptions in basic services, and the emigration of health workers during this humanitarian crisis have affected access to care throughout the country, as well as the capacity of emergency services and outbreak response. During the early waves of the epidemic, COVID-19 collapsed the Venezuelan health system, leaving sentinel centers without inpatient beds and ICU space. Home-based care alternatives quickly emerged, not only for mild to moderate but also for severe and critical COVID-19 cases. Here we discuss the impact of the pandemic on the Venezuelan health system, the emergence of home-based care alternatives for severe and critical COVID-19 cases, as well as their costs and challenges, and finally, their advantages and disadvantages.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 3","pages":"Article 103126"},"PeriodicalIF":4.7,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142744479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated serum and urinary secreted protein acidic and rich in cysteine levels are novel biomarkers of kidney fibrosis severity","authors":"Yang-yang Niu ,&nbsp;Ying Yu ,&nbsp;Wen-qian Zhou ,&nbsp;Xiao-qin Zhang ,&nbsp;Sai-ya Zhu ,&nbsp;Ying-ying Zhang ,&nbsp;Xin Li ,&nbsp;Hong-ping Shan ,&nbsp;Jian-ying Niu ,&nbsp;Tian-jun Guan ,&nbsp;Chen Yu","doi":"10.1016/j.arcmed.2024.103125","DOIUrl":"10.1016/j.arcmed.2024.103125","url":null,"abstract":"<div><h3>Background</h3><div>Interstitial fibrosis is the primary determinant of the progression of chronic kidney disease (CKD), and noninvasive identification of interstitial fibrosis is a major challenge. We aimed to explore the diagnostic value of secreted protein acidic and rich in cysteine (SPARC) in serum and urine in kidney fibrosis.</div></div><div><h3>Methods</h3><div>Single-cell transcriptome analysis was used to measure SPARC expression in healthy reference kidneys and those of patients with CKD. A total of 674 patients with CKD who underwent renal biopsy served as the training cohort (<em>n</em> = 322) and the validation cohort (<em>n</em> = 352). Serum and urinary SPARC levels were measured at the time of kidney biopsy. In vivo and in vitro models of kidney fibrosis were also used to confirm the role of SPARC.</div></div><div><h3>Results</h3><div>Increased SPARC expression was detected in kidney fibrosis tissues. Higher serum SPARC levels were associated with increased severity of kidney fibrosis. Moreover, the area under the receiver operating characteristic curve (AUC-ROC) (AUC 0.86) was greater for the serum SPARC level than for the urinary SPARC level and estimated glomerular filtration rate (eGFR). The combination of the serum and urinary SPARC levels and eGFR increased the AUC-ROC for predicting kidney fibrosis from 0.86 to 0.90. The diagnostic performance of serum or urinary SPARC levels was consistent in the validation cohort. In vivo and in vitro models of kidney fibrosis also confirmed the upregulation of SPARC expression.</div></div><div><h3>Conclusions</h3><div>Serum and urinary SPARC levels may be potential biomarkers for kidney fibrosis and may be useful for noninvasive diagnosis.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 3","pages":"Article 103125"},"PeriodicalIF":4.7,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142722410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laparoscopic robotic assisted surgery in reproductive medicine","authors":"Julio Ricardo Loret de Mola","doi":"10.1016/j.arcmed.2024.103137","DOIUrl":"10.1016/j.arcmed.2024.103137","url":null,"abstract":"<div><div>Laparoscopic Robot-assisted surgery is one of the most promising and rapidly developing surgical advancements of the twenty-first century with a potential to make significant contributions to reproductive medicine and preservation of fertility. Presently, laparoscopic robotic assisted surgery is used for various benign and malignant gynecological procedures, including fertility enhancing procedures. Laparoscopic Robot-assisted surgery is superior to traditional open procedures with regards to post-surgical hospital stay and blood loss; however, the difference is comparable to laparoscopic surgery. Regarding operative times, the results have been inconsistent due to variations in surgeons’ experience. The primary drawbacks of robotic systems are their high installation and maintenance costs and historical lack of tactile feedback; however, this has been overcome by the most recent evolution of robotic systems. Along with the major advances in cancer therapy, the number of female cancer survivors of reproductive age has dramatically increased. Consequently, fertility preservation and fertility enhancement have gained more emphasis in reproductive surgery in the last decade. A broad range of surgical procedures such as tubal reanastomosis, myomectomy, treatment of deep infiltrating endometriosis, ovarian transposition, radical trachelectomy, and ovarian transplantation has been introduced to restore or preserve fertility using Laparoscopic Robot-assisted surgery. In this article, we aim to present the current applications, advantages, and disadvantages of Laparoscopic Robot-assisted surgical technology in the field of reproductive surgery, including the more recent advances of Artificial Intelligence (AI) in the field.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"55 8","pages":"Article 103137"},"PeriodicalIF":4.7,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142723624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sperm human biobanking: An overview","authors":"Alfredo Góngora ,&nbsp;William V. Holt ,&nbsp;Jaime Gosálvez","doi":"10.1016/j.arcmed.2024.103130","DOIUrl":"10.1016/j.arcmed.2024.103130","url":null,"abstract":"<div><div>The purpose of this article is to analyze in detail the advantages and disadvantages of sperm cryopreservation, focusing on the cellular and molecular changes that occur during these processes. The main issue is the cellular damage caused by ice crystal formation and osmotic imbalance, along with other secondary effects such as sperm motility and viability, as well as the acrosome reaction or oxidative stress. Another important aspect is the examination of how chromatin structure and DNA integrity affect sperm. Biochemical changes affecting enzyme activity and protein stability have also been analyzed. Finally, the article highlights emerging technologies aimed at reducing the damage caused by sperm cryopreservation, as well as the potential benefits of biobanks as an essential resource for addressing male infertility.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"55 8","pages":"Article 103130"},"PeriodicalIF":4.7,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142723625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional status and incidence of hepatocellular carcinoma in patients with compensated liver cirrhosis","authors":"Marlene López-Sánchez ,&nbsp;Aleida Bautista-Santos ,&nbsp;María del Pilar Milke-García ,&nbsp;Aldo Allende-López ,&nbsp;Rosalba Moreno-Alcántar ,&nbsp;Segundo Morán","doi":"10.1016/j.arcmed.2024.103127","DOIUrl":"10.1016/j.arcmed.2024.103127","url":null,"abstract":"<div><h3>Background</h3><div>Malnutrition in patients with liver cirrhosis (LC) and/or hepatocellular carcinoma (HCC) has been associated with adverse outcomes. However, there is little information on the incidence of HCC during the compensated phase of LC in relation to the nutritional status.</div></div><div><h3>Aim</h3><div>To evaluate the association between the incidence of HCC in compensated LC and their nutritional status.</div></div><div><h3>Methods</h3><div>Patients with compensated liver cirrhosis with no previous history of ascites, hepatic encephalopathy, or variceal bleeding attending the Gastroenterology outpatient service at Centro Medico Nacional Siglo XXI were included in a prospective cohort. Clinical and nutritional parameters were collected, including the Royal Free Hospital Subjective Global Assessment (RFH-SGA) as an indicator of protein-calorie malnutrition and the triceps skinfold thickness, which classified patients as having <em>normal</em> subcutaneous adipose tissue (SAT), <em>above average</em> SAT, and <em>below average</em> SAT. Follow-up was censored at the time of HCC diagnosis or LC decompensation.</div></div><div><h3>Results</h3><div>About 31/187 (16.0 %) and 22/187 (11.8 %) patients were categorized as having above- or below-average SAT at baseline, respectively. 10/187 patients (5.3 %) developed HCC during the compensated phase of LC at a median of 22 months (IQR: 10.0–36.75). A higher risk of HCC was observed in subjects below average SAT (HR: 4.064, CI 95 %: 1.012–16.317, <em>p</em> = 0.048). After adjusting the Cox models for age and α-fetoprotein at baseline, the statistical significance of the association between SAT and HCC was not modified.</div></div><div><h3>Conclusion</h3><div>These results suggest that decreased SAT may precede the diagnosis of HCC in compensated LC.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 3","pages":"Article 103127"},"PeriodicalIF":4.7,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142698345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deficiency of miR-155 in leukemic B-cells results in cell cycle arrest and deregulation of MIR155HG/TP53INP1/CDKN1A/CCND1 network","authors":"Elena Golovina ,&nbsp;Juraj Kokavec ,&nbsp;Dmitry Kazantsev ,&nbsp;Oxana Yurikova ,&nbsp;Martin Bajecny ,&nbsp;Filipp Georgijevic Savvulidi ,&nbsp;Radim Simersky ,&nbsp;Rene Lenobel ,&nbsp;Jorg Tost ,&nbsp;Vit Herynek ,&nbsp;Ludek Sefc ,&nbsp;Marek Sebela ,&nbsp;Pavel Klener ,&nbsp;Zuzana Zemanova ,&nbsp;Tomas Stopka ,&nbsp;Karina Savvulidi Vargova","doi":"10.1016/j.arcmed.2024.103124","DOIUrl":"10.1016/j.arcmed.2024.103124","url":null,"abstract":"<div><h3>Background</h3><div>Cell cycle progression and leukemia development are tightly regulated processes in which even a small imbalance in the expression of cell cycle regulatory molecules and microRNAs (miRNAs) can lead to an increased risk of cancer/leukemia development. Here, we focus on the study of a ubiquitous, multifunctional, and oncogenic miRNA-hsa-miR-155–5p (miR-155, <em>MIR155HG</em>), which is overexpressed in malignancies including chronic lymphocytic leukemia (CLL). Nonetheless, the precise mechanism of how miR-155 regulates the cell cycle in leukemic cells remains the subject of extensive research.</div></div><div><h3>Methods</h3><div>We edited the CLL cell line MEC-1 by CRISPR/Cas9 to introduce a short deletion within the <em>MIR155HG</em> gene. To describe changes at the transcriptome and miRNome level in miR-155-deficient cells, we performed mRNA-seq/miRNA-seq and validated changes by qRT-PCR. Flow cytometry was used to measure cell cycle kinetics. A WST-1 assay, hemocytometer, and Annexin V/PI staining assessed cell viability and proliferation.</div></div><div><h3>Results</h3><div>The limited but phenotypically robust miR-155 modification impaired cell proliferation, cell cycle, and cell ploidy. This was accompanied by overexpression of the negative cell cycle regulator <em>p21/CDKN1A</em> and <em>Cyclin D1</em> (<em>CCND1</em>). We confirmed the overexpression of canonical miR-155 targets such as <em>PU.1, FOS, SHIP-1, TP53INP1</em> and revealed new potential targets (<em>FCRL5, ISG15,</em> and <em>MX1</em>).</div></div><div><h3>Conclusions</h3><div>We demonstrate that miR-155 deficiency impairs cell proliferation, cell cycle, transcriptome, and miRNome via deregulation of the <em>MIR155HG/TP53INP1/CDKN1A/CCND1</em> axis. Our CLL model is valuable for further studies to manipulate miRNA levels to revert highly aggressive leukemic cells to nearly benign or non-leukemic types.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 3","pages":"Article 103124"},"PeriodicalIF":4.7,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142698344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}