Archives of Medical Research最新文献

{"title":"Atherogenic Combined Index: Validation of a Novel Predictive Lipid Biomarker for the Presence and Severity of Coronary Artery Disease","authors":"Kenan Toprak ,&nbsp;Mustafa Kaplangöray ,&nbsp;Mesut Karataş ,&nbsp;Ayten Dursun ,&nbsp;Yakup Arğa ,&nbsp;Mustafa Begenc Tascanov ,&nbsp;Asuman Biçer ,&nbsp;Recep Demirbağ","doi":"10.1016/j.arcmed.2024.103065","DOIUrl":"10.1016/j.arcmed.2024.103065","url":null,"abstract":"<div><h3>Background/Aim</h3><p>The balance between atherogenic and antiatherogenic lipid particles significantly influences coronary artery disease (CAD), as an imbalance may contribute to the development and progression of atherosclerosis, which affects the risk and severity of CAD. This study aims to introduce and validate the atherogenic combined index (ACI) as a novel lipid biomarker that, comprehensively assesses the balance between atherogenic and antiatherogenic particles in the blood to effectively reflect the cumulative atherogenic effect and its association with the presence and severity of CAD.</p></div><div><h3>Material and Methods</h3><p>In this cross-sectional study, 1,830 patients diagnosed with CAD and a total of 650 patients without CAD were included in the study cohort for comprehensive analysis and comparison. Based on the tertiles of the SYNTAX score (SS), three subgroups of patients with CAD were identified. ACI and other atherogenic indices were compared to predict the presence and severity of CAD.</p></div><div><h3>Results</h3><p>The levels of ACI and other non-traditional lipid markers levels were higher in the CAD group compared to the non-CAD group (<em>p</em> &lt;0.05, for all). ACI showed a good linear association with the SYNTAX score (<em>r</em> = 0.527; <em>p</em> &lt;0.001). The multivariate logistic regression model showed that ACI was an independent predictor of the presence (OR: 1.602, 95% CI: 1.509–1.701, <em>p</em> &lt;0.001) and severity (OR: 1.296, 95% CI: 1.243–1.351, <em>p</em> &lt;0.001) of CAD after adjustment for various confounders.</p></div><div><h3>Conclusion</h3><p>The results suggest that ACI may serve as a promising and stronger tool for predicting the presence and severity of CAD.</p></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141891220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Effects of Exosomal miRNA-4731‐5p from Adipose Tissue-Derived Stem Cells on Human Glioblastoma Cells","authors":"Abouzar Babaei ,&nbsp;Amin Torabi Yazdi ,&nbsp;Reza Ranji ,&nbsp;Ensiyeh Bahadoran ,&nbsp;Shiva Taheri ,&nbsp;Farhad Nikkhahi ,&nbsp;Saied Ghorbani ,&nbsp;Ardeshir Abbasi","doi":"10.1016/j.arcmed.2024.103061","DOIUrl":"10.1016/j.arcmed.2024.103061","url":null,"abstract":"<div><h3>Background and aim</h3><p>Several microRNAs (miRNAs) are differentially expressed and serve as tumor suppressors in glioblastoma (GBM). The present study aimed to elucidate the function of exosomal microRNA‐4731-5p (miR-4731-5p) from adipose tissue-derived mesenchymal stem cells (AD-MSCs) in the activity of human GBM cell lines.</p></div><div><h3>Method</h3><p>First, GBM-related miRNAs, their expression, and potential target genes and cytokines of miR-4731-5p were identified using bioinformatic datasets. Subsequently, purified AD-MSCs were transfected with a miRNA-4731‐5p expression plasmid, and exosomes were isolated and characterized. Next, the transfection process was confirmed and the 50% inhibitory concentration (IC50) of the overexpressed exosomal miRNA-4731‐5p was inhibited for cancer cells. The probable anticancer action of exosomal miRNA-4731‐5p on U‐87 and U‐251 GBM cell lines was verified by flow cytometry, DAPI staining, cell cycle, real-time PCR, and wound healing assays.</p></div><div><h3>Results</h3><p>A concentration of 50 ng/mL of miRNA-4731-5p-transfected exosomes was the safe dose for anticancer settings. The results showed that the exosomal miR-4731-5p exerted an inhibitory effect on the cell cycle and migration and induced apoptosis in GBM cell lines by regulating the phosphoinositide-3-kinase-AKT (PI3K-AKT) and nuclear factor-kB (NF-kB) signaling pathways.</p></div><div><h3>Conclusion</h3><p>This study reveals that the expression of exosomal miRNA-4731-5p has favorable antitumor properties for the treatment of GBM cell lines and may be a fundamental therapeutic option for this type of brain tumor.</p></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141891248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global prevalence of nonalcoholic fatty liver disease: an updated meta-analysis on 78 million population over 38 countries","authors":"Ehsan Amini-Salehi ,&nbsp;Negin Letafatkar ,&nbsp;Naeim Norouzi ,&nbsp;Farahnaz Joukar ,&nbsp;Arman Habibi ,&nbsp;Mona Javid ,&nbsp;Nazila Sattari ,&nbsp;Mehrdad Khorasani ,&nbsp;Ali Farahmand ,&nbsp;Shervin Tavakoli ,&nbsp;Behnaz Masoumzadeh ,&nbsp;Elaheh Abbaspour ,&nbsp;Sahand Karimzad ,&nbsp;Amir Ghadiri ,&nbsp;Gautam Maddineni ,&nbsp;Mohammad Javad Khosousi ,&nbsp;Niloofar Faraji ,&nbsp;Mohammad-Hossein Keivanlou ,&nbsp;Abinash Mahapatro ,&nbsp;Mohamad Amin Khajavi Gaskarei ,&nbsp;Sandeep Samethadka Nayak","doi":"10.1016/j.arcmed.2024.103043","DOIUrl":"10.1016/j.arcmed.2024.103043","url":null,"abstract":"<div><h3>Background</h3><p>Nonalcoholic fatty liver disease (NAFLD) is a global health challenge, with a rising rate in line with other metabolic diseases. We aimed to assess the global prevalence of NAFLD in adult and pediatric populations.</p></div><div><h3>Methods</h3><p>PubMed, Scopus and Web of Science databases were systematically searched up to May 2023. Heterogeneity was assessed using Cochran's Q test and <em>I</em>² statistics, and random-effects model was used for meta-analysis. Analyses were performed using STATA version 18.</p></div><div><h3>Results</h3><p>A total of 479 studies with 78,001,755 participants from 38 countries were finally included. The global prevalence of NAFLD was estimated to be 30.2% (95% CI: 28.7–31.7%). Regionally, the prevalence of NAFLD was as follows: Asia 30.9% (95% CI: 29.2–32.6%), Australia 16.1% (95% CI: 9.0–24.8%), Europe 30.2% (95% CI: 25.6–35.0%), North America 29% (95% CI: 25.8–32.3%), and South America 34% (95% CI: 16.9–53.5%). Countries with a higher human development index (HDI) had significantly lower prevalence of NAFLD (coefficient = –0.523, <em>p</em> = 0.005). Globally, the prevalence of NAFLD in men and women was 36.6% (95% CI: 34.7–38.4%) and 25.5% (95% CI: 23.9–27.1%), respectively. The prevalence of NAFLD in adults, adults with obesity, children, and children with obesity was 30.2% (95% CI: 28.8–31.7%), 57.5% (95% CI: 43.6–70.9%), 14.3% (95% CI: 10.3–18.8%), and 38.0% (95% CI: 31.5–44.7%), respectively.</p></div><div><h3>Conclusion</h3><p>The prevalence of NAFLD is remarkably high, particularly in countries with lower HDI. This substantial prevalence in both adults and children underscores the need for disease management protocols to reduce the burden.</p></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Activity Prediction Modeling Based on a Combination of Growth Differentiation Factor 15 and Serum Biomarker Levels in Dermatomyositis and Polymyositis","authors":"Qiong Wu ,&nbsp;Wei Wang ,&nbsp;Ling Qiu,&nbsp;Wanchan Peng,&nbsp;Yunli Zhang,&nbsp;Jinfang Fu,&nbsp;Siyu Wu","doi":"10.1016/j.arcmed.2024.103058","DOIUrl":"10.1016/j.arcmed.2024.103058","url":null,"abstract":"<div><h3>Aims</h3><p>Growth differentiation factor 15 (GDF15) plays an important role in multiple inflammatory disorders. We aimed to analyze serum GDF15 levels in adult patients with idiopathic inflammatory myopathies (IIMs).</p></div><div><h3>Methods</h3><p>Serum GDF15 levels were measured in 179 adult patients with IIMs and 76 healthy controls (HCs). The association between GDF15 levels and disease variables was analyzed using Spearman's rank correlation. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the discriminatory ability of GDF15 and the GDF15-to-lymphocyte ratio (GLR). Machine learning methods were applied to build predictive models.</p></div><div><h3>Results</h3><p>GDF15 levels and GLR were significantly elevated in patients with adult IIMs than in HCs. Compared with patients in remission, both GDF15 and GLR were significantly higher in myositis patients in an active phase. GDF15 levels correlated positively with myositis disease activity indices and negatively correlated with lymphocyte and platelet counts. ROC curve analysis revealed that GDF15 levels and GLR outperformed muscle enzymes and distinguished well between patients with active disease and those in remission. Furthermore, even in the normal muscle enzyme group, GDF15 levels and GLR were also well-distinguished between patients with active disease and those in remission. Using machine learning, a logistic regression model of GDF15 combined with creatine kinase and lymphocyte count was constructed and had a reliable predictive value for disease activity.</p></div><div><h3>Conclusions</h3><p>GDF15, particularly GLR, was significantly correlated with disease activity in adult patients with IIMs. They could serve as useful biochemical markers for evaluating disease activity, monitoring disease progression, and guiding treatment in adult patients with IIMs.</p></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary Patterns and Geriatric Syndromes in older Mexican adults: Analysis of the 2018-19 National Health and Nutrition Survey","authors":"Vanessa De la Cruz-Góngora ,&nbsp;Betty Manrique-Espinoza ,&nbsp;Aarón Salinas-Rodríguez ,&nbsp;Brenda Martinez-Tapia ,&nbsp;Mario Flores-Aldana ,&nbsp;Teresa Shamah-Levy","doi":"10.1016/j.arcmed.2024.103044","DOIUrl":"10.1016/j.arcmed.2024.103044","url":null,"abstract":"<div><h3>Background</h3><p>The study of dietary patterns in older adults (OA) and their association with geriatric syndromes (GS) is scarce in Latin America.</p></div><div><h3>Objective</h3><p>To describe the association of dietary patterns with GS in the Mexican older adult population, using data from the 2018-19 National Health and Nutrition Survey.</p></div><div><h3>Methods</h3><p>Dietary data were collected from 3,511 adults (≥60 years of age, both sexes) using a semi-quantitative food frequency questionnaire. Dietary patterns were derived by principal component analysis based on the consumption of 162 foods from 24 food groups. The GS studied were: frailty, depressive symptoms (DS), low appendicular skeletal muscle mass (ASMM); additionally, we studied inflammation (serum CRP&gt;5 mg/L). Logistic regression models were used.</p></div><div><h3>Results</h3><p>Four major dietary patterns were identified: a) “Western”, b) “Prudent”, c) “Soups”, and d) “Traditional”. The middle and higher tertiles of the “Prudent” pattern were associated with lower odds of DS (OR 0.71, <em>p</em> = 0.04; and OR 0.61, <em>p</em> = 0.008), respectively. The second tertile of the “Soups” pattern was associated with lower odds of low ASMM (OR 0.68, <em>p</em> = 0031) and inflammation (OR 0.58, <em>p</em> = 0.022). The highest tertile of the “Traditional” pattern was associated with low ASMM (OR 1.55, <em>p</em> = 0.008) and lower odds of inflammation (OR 0.69, <em>p</em> = 0.044). No association was found between the “Western” dietary pattern and GS.</p></div><div><h3>Conclusions</h3><p>Three of four major dietary patterns were associated with GS in older Mexican adults. Further studies are needed to address strategies to improve diet quality in this age group and its association with health and functional outcomes.</p></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-Dose Thymoglobulin versus Basiliximab Induction Therapy in Low-Risk Living Related Kidney Transplant Recipients: Three-Year Follow-Up Study","authors":"Gustavo Martinez-Mier ,&nbsp;Pedro I. Moreno-Ley ,&nbsp;Luis F. Budar-Fernández ,&nbsp;Marco T. Méndez-López ,&nbsp;Carlos A. Allende-Castellanos ,&nbsp;Luis A. Jiménez-López ,&nbsp;Daniel A. Barrera-Amoros ,&nbsp;José Manuel Reyes-Ruiz","doi":"10.1016/j.arcmed.2024.103047","DOIUrl":"10.1016/j.arcmed.2024.103047","url":null,"abstract":"<div><h3>Background</h3><p>The optimal dose of rabbit anti-thymocyte globulin (r-ATG) in renal transplantation is still under debate. We previously reported that a low-dose r-ATG induction of 3 mg/kg can be used safely and effectively in low-risk kidney transplants with good results in the first year after transplantation compared to basiliximab induction.</p></div><div><h3>Aims</h3><p>The purpose of this study is to evaluate the long-term impact of this trial of low-dose r-ATG versus basiliximab on post-transplant outcomes (patient and graft survival, biopsy-proven acute rejection incidence [BPAR], infectious complications, and side effects).</p></div><div><h3>Methods</h3><p>Observational study (three-year follow-up) of a 12-month single-center, open-label RCT in <em>de novo</em> kidney allograft recipients assigned to receive either thymoglobulin or basiliximab before transplantation.</p></div><div><h3>Results</h3><p>Patients in the basiliximab group (BG) underwent more kidney transplant biopsies than patients in the low-dose r-ATG group (TG) (50 vs. 31.8%, <em>p</em> = 0.07). Although the 12-month cumulative incidence of BPAR was lower in BG, by the end of the three-year follow-up period this incidence was higher (22%) than in the low-dose TG (15%) (<em>p</em> = <em>ns</em>). Steroids were withdrawn more frequently in the TG group and sirolimus was most frequently indicated. Graft function and graft survival were higher in the low-dose TG than in the BG at three-year follow-up but not statistically significant. Patient survival was similar between groups (&gt;90%).</p></div><div><h3>Conclusions</h3><p>These three-year follow-up data confirm the efficacy and favorable safety aspects of the low-dose r-ATG (3 mg/kg) in low-risk kidney transplantation.</p></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141857382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elder Abuse and Depressive Symptoms: The Mediating Role of Loneliness in Older Adults","authors":"Liliana Giraldo-Rodríguez ,&nbsp;Marcela Agudelo-Botero ,&nbsp;Mario E. Rojas-Russell","doi":"10.1016/j.arcmed.2024.103045","DOIUrl":"10.1016/j.arcmed.2024.103045","url":null,"abstract":"<div><h3>Background</h3><p>Elder abuse (EA), depressive symptoms, and loneliness represent a growing risk to the health, well-being, and premature mortality of older adults. However, the role of loneliness in the relationship between EA and depressive symptoms has not yet been examined.</p></div><div><h3>Aims</h3><p>To investigate the associations between these constructs and to explore the possible mediating role of loneliness in the relationship between EA and depressive symptoms in a representative sample of older Mexican people.</p></div><div><h3>Methods</h3><p>A representative community-dwelling survey of older adults aged 60 and older was conducted in two cities in Mexico (Mexico City and Xalapa) in 2018–2019. Measurements of EA, loneliness, depressive symptoms, health, and sociodemographic data were collected. Regression and mediation models were tested to analyze the associations between these variables.</p></div><div><h3>Results</h3><p>The prevalence of EA was 16.3%, loneliness was 50%, and depressive symptoms were 25.5%. The odds ratio (OR) for the occurrence of depressive symptoms was 2.7 when the combined effects of EA and loneliness were considered. The proportion of the effect that could explain the mediating role of loneliness was 31%.</p></div><div><h3>Conclusion</h3><p>To effectively reduce depressive symptoms in older individuals affected by emotional or psychological abuse and neglect, it is crucial to address both the mediating influence of loneliness and EA itself in therapeutic and preventive interventions.</p></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0188440924000973/pdfft?md5=5c85bbbe3dba931b043f8999a4abb41d&pid=1-s2.0-S0188440924000973-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141790287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Red Blood Cell Distribution Width in Late Pregnancy and the Incidence of Adverse Perinatal Outcomes: A Retrospective Cohort Study","authors":"Bin Zhang ,&nbsp;Xiaoya Han ,&nbsp;Wei Long,&nbsp;Sijie Xi,&nbsp;Bin Yu,&nbsp;Xiaosong Yuan","doi":"10.1016/j.arcmed.2024.103057","DOIUrl":"10.1016/j.arcmed.2024.103057","url":null,"abstract":"<div><h3>Background and Aims</h3><p>This study aimed to quantify adverse perinatal outcomes (APO), including small/large for gestational age (SGA/LGA) and preterm birth (PTB), in pregnant women with abnormal red cell distribution width (RDW) and explore the related mechanisms.</p></div><div><h3>Methods</h3><p>This study included 11,659 pregnant women who delivered in a specialized hospital. At the time of admission, the lipid profiles and whole blood cell counts were assessed, and APO was analyzed.</p></div><div><h3>Results</h3><p>Women with high RDW (&gt;18.5% [the 97.5^th percentile]) in late pregnancy had a higher risk of LGA compared with those with low RDW (&lt;12.3% [the 2.5^th percentile]), whereas women with low RDW had a higher risk of SGA and PTB, compared with those with high RDW. A 1% increase in RDW was associated with an increased risk of LGA and a decreased risk of SGA and PTB. Consistent associations were observed in sensitivity analysis among pregnant women of non-advanced age, non-obesity, non-pregnancy complications, and non-PTB (for SGA/LGA only). Increased RDW was significantly associated with increased triglycerides and decreased high-density lipoprotein cholesterol (HDL-C). Triglycerides and HDL-C significantly mediated 10.63 and 15.8% of RDW-associated LGA, 9.51% and 9.40 of RDW-associated SGA, and 8.44 and –8.25% of RDW-associated PTB, respectively.</p></div><div><h3>Conclusion</h3><p>Abnormal RDW was associated with an increased risk of APO, and the RDW-associated APO risk could be partially mediated by triglycerides and HDL-C, suggesting that RDW may be a promising APO predictor.</p></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141790288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Life Satisfaction Trajectories and Associated Factors in Middle-Aged and Older Mexican Adults","authors":"Rosa Estela García-Chanes ,&nbsp;Mariana López-Ortega ,&nbsp;Sara Torres-Castro","doi":"10.1016/j.arcmed.2024.103040","DOIUrl":"10.1016/j.arcmed.2024.103040","url":null,"abstract":"<div><h3>Background</h3><p>Given the importance of understanding psychosocial well-being as part of aging characteristics and processes, the present study aimed to describe life satisfaction among middle-aged and older adults in Mexico, according to sociodemographic, economic, psychosocial, and health factors.</p></div><div><h3>Methods</h3><p>Data were obtained from the Mexican Health and Aging Study (MHAS), a longitudinal, nationally representative survey of adults aged 50 years and older. Data from the 2012, 2015, and 2018 waves were analyzed for this study. Life satisfaction in the MHAS is assessed using the Spanish version of the Satisfaction with Life Scale (SWLS). For the construction of the trajectories over six years of follow-up, quartiles of the scale were calculated for each wave. Multinomial regression models were then estimated to determine significant factors associated with each trajectory.</p></div><div><h3>Results</h3><p>A total of 8,376 individuals aged 50 years and older met our study criteria for complete data in the three follow-up waves. Four life satisfaction trajectories were identified over six years of follow-up: high-constant, high-low, low-high, and low-constant. Subjective or psychosocial characteristics such as depressive symptoms, self-reported health, and functional ability were highly significant factors associated with life satisfaction trajectories, while multimorbidity was not significant.</p></div><div><h3>Conclusions</h3><p>This research contributes to the understanding of psychosocial well-being in Mexican older adults by exploring life satisfaction trajectories and their associated factors. The study shows that psychosocial and economic factors, along with functional abilities, have a much greater impact on life satisfaction, beyond the presence of comorbidity.</p></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141729219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oops! ... They did it again-The Reasons Behind so Many Retractions of Scientific Articles","authors":"Lucindo José Quintans-Júnior ,&nbsp;Paulo Ricardo Martins-Filho","doi":"10.1016/j.arcmed.2024.103056","DOIUrl":"10.1016/j.arcmed.2024.103056","url":null,"abstract":"","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141728431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}