Single Nucleotide Variants of the SLC2A9 Gene are Associated With Hyperuricemia in Mexican Patients With Type 2 Diabetes

IF 4.7 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Archives of Medical Research Pub Date : 2025-05-14 DOI:10.1016/j.arcmed.2025.103235

Gloria Elizabeth Vázquez-Rivera , Erika F. Gómez-García , Renato Parra-Michel , Rosalba Orozco-Sandoval , Lourdes del Carmen Rizo-de la Torre , Caridad A. Leal-Cortés , Claudia Nayeli Contreras-Aceves , Mariana Pérez-Coria , Alfonso Farías-Basulto , Francisco Mendoza-Carrera

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引用次数: 0

Abstract

Background

Chronic kidney disease (CKD) due to diabetes is the third leading cause of death in Mexico. A relationship between high serum uric acid (SUA) levels and kidney disease have been demonstrated. On the other hand, variants of the SLC2A9 gene have been associated with elevated SUA concentrations. This study evaluated the associations of the rs11722228, rs3775948, rs7678287, and rs1014290 variants with hyperuricemia and biochemical parameters in patients with type 2 diabetes (T2D).

Methods

The study included 1036 Mexican subjects with T2D. Patients were grouped based on the presence (n = 462) or absence (n = 574) of diabetic kidney disease (DKD). SUA concentrations and biochemical parameters were determined. Samples were genotyped through real-time polymerase chain reaction. Associations between genetic variants and hyperuricemia were analyzed by univariate and multivariate models adjusting for covariates.

Results

SUA levels and hyperuricemia prevalence were higher in the DKD group. rs3775948 and rs1014290 showed negative associations with hyperuricemia in the whole sample and in patients without DKD. rs7678287 was positively correlated with SUA and hyperuricemia in patients without DKD, whereas rs11722228 was a risk factor only in the DKD group. The presence of DKD and elevated triglycerides and total cholesterol were significant factors associated with hyperuricemia.

Conclusions

Variants rs3775948 and rs1014290 exhibit protective effects, while rs7678287 and rs11722228 may confer increased risk of hyperuricemia in Mexican patients with T2D. Analysis of SLC2A9 gene variants could help in detecting patients at increased risk of kidney or cardiovascular complications due to hyperuricemia.

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SLC2A9基因的单核苷酸变异与墨西哥2型糖尿病患者的高尿酸血症有关

背景：糖尿病引起的慢性肾脏疾病（CKD）是墨西哥第三大死亡原因。高血清尿酸（SUA）水平与肾脏疾病之间的关系已得到证实。另一方面，SLC2A9基因的变异与SUA浓度升高有关。本研究评估了rs11722228、rs3775948、rs7678287和rs1014290变异与2型糖尿病（T2D）患者高尿酸血症和生化参数的关系。方法纳入墨西哥T2D患者1036例。根据存在（n = 462）或不存在（n = 574）糖尿病肾病（DKD）对患者进行分组。测定SUA浓度及生化指标。通过实时聚合酶链反应对样品进行基因分型。通过调整协变量的单变量和多变量模型分析遗传变异与高尿酸血症之间的关系。结果DKD组的sua水平和高尿酸血症发生率较高。rs3775948和rs1014290与全样本和无DKD患者的高尿酸血症呈负相关。rs7678287与无DKD患者的SUA和高尿酸血症呈正相关，而rs11722228仅在DKD组中是危险因素。DKD、甘油三酯和总胆固醇升高是与高尿酸血症相关的重要因素。结论变异rs3775948和rs1014290具有保护作用，而rs7678287和rs11722228可能会增加墨西哥T2D患者高尿酸血症的风险。对SLC2A9基因变异的分析有助于发现高尿酸血症引起的肾脏或心血管并发症风险增加的患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Medical Research 医学-医学：研究与实验

CiteScore

12.50

自引率

0.00%

发文量

审稿时长

28 days

期刊介绍： Archives of Medical Research serves as a platform for publishing original peer-reviewed medical research, aiming to bridge gaps created by medical specialization. The journal covers three main categories - biomedical, clinical, and epidemiological contributions, along with review articles and preliminary communications. With an international scope, it presents the study of diseases from diverse perspectives, offering the medical community original investigations ranging from molecular biology to clinical epidemiology in a single publication.