Archives of Medical Research最新文献_第8页

Being the Chief Editor of a Scientific Journal 成为科学期刊的主编

IF 3.4 3区医学

Archives of Medical Research Pub Date : 2026-01-01 Epub Date: 2025-12-20 DOI: 10.1016/j.arcmed.2025.103370

Mardia López-Alarcón

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Neuromodulation and Exercise Therapy: A Synergistic Approach to Improve Physical Mobility 神经调节和运动疗法：一种提高身体活动能力的协同方法

IF 3.4 3区医学

Archives of Medical Research Pub Date : 2026-01-01 Epub Date: 2025-08-20 DOI: 10.1016/j.arcmed.2025.103282

JIA DONG JAMES WANG , LING-LING CHAN , YEW LONG LO , ENG KING TAN

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Use and Conditions of a Breastfeeding Room in a Tertiary Health Institution: An Exploratory Study 三级卫生机构母乳喂养室的使用和条件：一项探索性研究

IF 3.4 3区医学

Archives of Medical Research Pub Date : 2026-01-01 Epub Date: 2025-08-28 DOI: 10.1016/j.arcmed.2025.103284

Loraine Ledón-Llanes , Martha Kaufer-Horwitz , Consuelo Lomas-Soria , Berenice Palacios-González , Elena Zambrano

{"title":"Use and Conditions of a Breastfeeding Room in a Tertiary Health Institution: An Exploratory Study","authors":"Loraine Ledón-Llanes , Martha Kaufer-Horwitz , Consuelo Lomas-Soria , Berenice Palacios-González , Elena Zambrano","doi":"10.1016/j.arcmed.2025.103284","DOIUrl":"10.1016/j.arcmed.2025.103284","url":null,"abstract":"<div><h3>Background</h3><div>Creating environments that facilitate breastfeeding (BF) practice in the workplace is an effective way to promote BF. However, few studies have addressed this sensitive and relevant topic in Mexican healthcare institutions.</div></div><div><h3>Objective</h3><div>Describe the conditions and use of the breastfeeding room (BFR) at a tertiary health institution and identify the perceptions of reproductive-age female workers, and the department heads and human resources staff (DH/HR).</div></div><div><h3>Methods</h3><div>A cross-sectional study (observational and exploratory) was conducted with 150 female reproductive-age workers and 41 DH/HR staff. They completed self-administered questionnaires, and responded to a semi-structured interview guide designed for the study. Participant observations were conducted in the BFR. Descriptive and inferential analyses were performed, considering statistical significance at <em>p</em><0.05.</div></div><div><h3>Results</h3><div>Only 40 of the women of reproductive-age were aware of the existence of the BFR; and only one of the 20 who knew the specific location considered it to have proper conditions for milk extraction and storage. Between 21 and 28% of the participants considered that BF promotion actions were being conducted at the Institute. Although 61% of DH/HR reported knowing the existence of the BFR, the majority (80%) did not know if any female worker had used it.</div></div><div><h3>Conclusions</h3><div>Most of the Institute’s female workers of reproductive age did not know of the BFR’s existence, seldom used it, and said it lacked optimal conditions. Efforts to improve BFR conditions and functioning, as well as raise breastfeeding awareness at the workplace must be systematically promoted.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"57 1","pages":"Article 103284"},"PeriodicalIF":3.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144908051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Hot Topics in Gastroenterology and Hepatology 胃肠病学和肝病学热点话题。

IF 3.4 3区医学

Archives of Medical Research Pub Date : 2025-12-01 Epub Date: 2025-11-12 DOI: 10.1016/j.arcmed.2025.103347

Ludovico Abenavoli , Nahum Méndez-Sánchez

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Challenges in Expanding the Donor Pool and Improving Long-Term Outcomes for Liver Transplantation 扩大供体池和改善肝移植长期预后的挑战。

IF 3.4 3区医学

Archives of Medical Research Pub Date : 2025-12-01 Epub Date: 2025-11-20 DOI: 10.1016/j.arcmed.2025.103348

Alberto Ferrarese , Sara Battistella , Francesca D’Arcangelo , Giuseppe Feltrin , Stefania Barbieri , Domenico Bassi , Alberto Zanetto , Giacomo Germani , Francesco Paolo Russo , Patrizia Burra

{"title":"Challenges in Expanding the Donor Pool and Improving Long-Term Outcomes for Liver Transplantation","authors":"Alberto Ferrarese , Sara Battistella , Francesca D’Arcangelo , Giuseppe Feltrin , Stefania Barbieri , Domenico Bassi , Alberto Zanetto , Giacomo Germani , Francesco Paolo Russo , Patrizia Burra","doi":"10.1016/j.arcmed.2025.103348","DOIUrl":"10.1016/j.arcmed.2025.103348","url":null,"abstract":"<div><div>Liver transplantation is a curative treatment for many patients with end-stage liver disease, acute liver failure, and primary liver cancer when certain criteria are met. The persistent imbalance between organ availability and the number of patients on the waiting list presents both ethical and medical challenges in everyday clinical practice. Expanding the donor pool—and consequently increasing the number of retrieved grafts—requires action on multiple levels. These include raising awareness about organ donation, promoting willingness to donate, and increasing knowledge of post-transplant outcomes among the general population and healthcare professionals. In addition, organ acceptance criteria should be refined by incorporating recent advances in transplant hepatology and surgery. The survival benefit achieved through liver transplantation is well established for many conditions. To further improve long-term outcomes, more tailored and refined surveillance protocols are needed for the metabolic and neoplastic comorbidities that commonly develop after transplantation. In this updated literature review, we aim to highlight the main advances in these two crucial areas of liver transplantation.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 8","pages":"Article 103348"},"PeriodicalIF":3.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145575084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanism of SENP1-Mediated Regulation of Liver Sinusoidal Endothelial Cells to Promote Regeneration Via the HIF-1α Signaling Pathway senp1通过HIF-1α信号通路调控肝窦内皮细胞促进再生的机制

IF 3.4 3区医学

Archives of Medical Research Pub Date : 2025-12-01 Epub Date: 2025-08-22 DOI: 10.1016/j.arcmed.2025.103295

Zhe Qing , Jian Duan , Qun Luo , Jinlan He , Hanfei Huang , Zhong Zeng

{"title":"Mechanism of SENP1-Mediated Regulation of Liver Sinusoidal Endothelial Cells to Promote Regeneration Via the HIF-1α Signaling Pathway","authors":"Zhe Qing , Jian Duan , Qun Luo , Jinlan He , Hanfei Huang , Zhong Zeng","doi":"10.1016/j.arcmed.2025.103295","DOIUrl":"10.1016/j.arcmed.2025.103295","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Liver sinusoidal endothelial cells (LSECs) play a critical role in liver regeneration, but the specific molecular mechanism underlying this process remains unclear. Previous studies have shown that Sentrin/SUMO-specific protease 1 (SENP1) maintains the differentiation state of LSECs and promotes their proliferation under hypoxic conditions; however, the role of SENP1 in promoting liver regeneration by regulating LSECs is still unknown.</div></div><div><h3>Methods</h3><div>We employed a 70% hepatectomy (PHx) mouse model to explore the molecular mechanism underlying SENP1 regulation of LSECs and to observe the promotion of liver regeneration via the HIF-1α signaling pathway <em>in vitro</em> and <em>in vivo.</em></div></div><div><h3>Results</h3><div>First, we found that the liver regeneration began on the first day after hepatectomy, while SENP1 expression in liver tissue was significantly upregulated. After SENP1 downregulation, the expression of Ki-67 and von Willebrand factor (vWF) in liver tissue decreased, as did the rate of liver regeneration. Second, <em>in vitro</em>, the proliferation activity of LSECs with SENP1 overexpression increased, and fenestration was better maintained. After co-culturing hepatocytes with LSECs that overexpress SENP1, an EdU assay showed that hepatocyte proliferation ability increased significantly. However, the opposite occurred when either a SENP1 or a HIF-1α inhibitor was used. <em>In vivo</em>, we observed that SENP1 can activate the VEGF/VEGFR2/Id1 signaling axis, upregulating the expression of VEGF and HGF through the HIF-1α signaling pathway, thus promoting hepatocyte proliferation and angiogenesis.</div></div><div><h3>Conclusions</h3><div>SENP1 may promote liver regeneration by regulating LSECs dependent on the HIF-1α signaling pathway.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 8","pages":"Article 103295"},"PeriodicalIF":3.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144887245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Diagnostic Evaluation of Seronegative Celiac Disease 血清阴性乳糜泻的诊断评价。

IF 3.4 3区医学

Archives of Medical Research Pub Date : 2025-12-01 Epub Date: 2025-11-29 DOI: 10.1016/j.arcmed.2025.103338

Andrew Ford , Claire Jansson-Knodell , Alberto Rubio Tapia

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Global Burden of Peptic Ulcer Disease in Adolescents and Young Adults: Trends and Disparities from 1990–2021 青少年和年轻人消化性溃疡疾病的全球负担：1990-2021年的趋势和差异

IF 3.4 3区医学

Archives of Medical Research Pub Date : 2025-12-01 Epub Date: 2025-09-18 DOI: 10.1016/j.arcmed.2025.103320

Tai Zhang , Beihua Zhang , Xudong Tang

{"title":"Global Burden of Peptic Ulcer Disease in Adolescents and Young Adults: Trends and Disparities from 1990–2021","authors":"Tai Zhang , Beihua Zhang , Xudong Tang","doi":"10.1016/j.arcmed.2025.103320","DOIUrl":"10.1016/j.arcmed.2025.103320","url":null,"abstract":"<div><h3>Background</h3><div>Peptic ulcer disease (PUD) significantly impacts adolescents and young adults (15–49 years), yet there are limited comprehensive analyses of its burden in this age group. This study examines global, regional, and national trends in PUD epidemiology from 1990–2021.</div></div><div><h3>Methods</h3><div>Using data from the 2021 Global Burden of Disease (GBD) Study, we analyzed PUD prevalence, incidence, disability-adjusted life years (DALYs), and mortality across 204 countries, stratified by age, sex, socio-demographic index (SDI), and GBD regions. Trends were quantified using estimated annual percentage changes (EAPC) and joinpoint regression.</div></div><div><h3>Results</h3><div>From 1990–2021, the global prevalence and incidence rates of PUD declined by 32.9 and 32.3%, respectively. Mortality and DALY rates decreased by 60.6 and 60.0%), respectively. Absolute cases increased by 50% in low SDI regions, while reductions were observed in middle SDI regions. South Asia and Western Sub-Saharan Africa had the highest prevalence rates. Sex disparities were evident, with males aged 45–49 having a prevalence rate that was 1.4-fold higher and a mortality rate that was 2.2-fold higher than females. Socioeconomic development inversely correlated with DALY rates (<em>R</em> = –0.708), but progress slowed after 2015 in high SDI regions.</div></div><div><h3>Conclusions</h3><div>The rising number of PUD cases in low SDI regions reflects population growth and limited healthcare access. Disparities highlight the need for targeted strategies. The slowed progress in high SDI regions indicates aging and evolving disease patterns. Tailored interventions are key for equitable control.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 8","pages":"Article 103320"},"PeriodicalIF":3.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145093046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-Invasive Testing in Metabolic Dysfunction Associated Fatty Liver Disease 代谢功能障碍相关脂肪性肝病的无创检测。

IF 3.4 3区医学

Archives of Medical Research Pub Date : 2025-12-01 Epub Date: 2025-10-31 DOI: 10.1016/j.arcmed.2025.103337

Cameron Gofton , Jacob George

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Metabolic Dysfunction-Associated Steatohepatitis in Focus: Pathogenesis, Non-Invasive Diagnostics, and Future Approaches 代谢功能障碍相关脂肪性肝炎的焦点：发病机制，非侵入性诊断和未来的方法

IF 3.4 3区医学

Archives of Medical Research Pub Date : 2025-12-01 Epub Date: 2025-11-29 DOI: 10.1016/j.arcmed.2025.103350

Abdulrahman Ismaiel , Mhd Bashir Almonajjed , Cristina Sorina Catana , Stefan-Lucian Popa , Dan L. Dumitrascu

{"title":"Metabolic Dysfunction-Associated Steatohepatitis in Focus: Pathogenesis, Non-Invasive Diagnostics, and Future Approaches","authors":"Abdulrahman Ismaiel , Mhd Bashir Almonajjed , Cristina Sorina Catana , Stefan-Lucian Popa , Dan L. Dumitrascu","doi":"10.1016/j.arcmed.2025.103350","DOIUrl":"10.1016/j.arcmed.2025.103350","url":null,"abstract":"<div><div>Metabolic dysfunction-associated steatohepatitis (MASH) has become a critical public health concern, representing the progressive form of metabolic dysfunction-associated steatotic liver disease (MASLD). MASH is characterized by hepatic steatosis, inflammation, hepatocyte ballooning, and fibrosis, which increase the risk of cirrhosis and hepatocellular carcinoma. Closely linked to obesity, insulin resistance, and metabolic syndrome, MASH affects a significant proportion of the global population, requiring accurate diagnostic tools and tailored interventions. This manuscript delves into the current understanding of MASH, focusing on its pathophysiology, diagnostic challenges, and innovative non-invasive strategies. While liver biopsy remains the gold standard for diagnosis, its invasiveness and limitations have prompted the search for alternative approaches. Promising non-invasive techniques, such as elastography, MRI-based techniques, and serum biomarkers like cytokeratin-18, NIS4, and FAST scores, provide new ways to detect MASH and evaluate fibrosis severity. The updated MASLD criteria refine risk stratification further, capturing a broader range of at-risk individuals, including lean phenotypes. As MASH continues to strain healthcare systems worldwide, this review underscores the importance of advancing non-invasive diagnostics and integrating multi-omics approaches. Future research should focus on developing personalized strategies to halt disease progression, enhance early detection, and optimize patient outcomes.</div></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 8","pages":"Article 103350"},"PeriodicalIF":3.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145620718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0