Archives of Medical Research最新文献

{"title":"Integrative Transcriptomic Analysis of Peripheral Blood Monocytes in Systemic Sclerosis and Shared Pathogenic Pathways in Autoimmune Diseases","authors":"Shaoqi Chen ,&nbsp;Yu Fan ,&nbsp;Qiulin Wu ,&nbsp;Guohong Zhang ,&nbsp;Yukai Wang ,&nbsp;Weiping Li ,&nbsp;Shengli Yang ,&nbsp;Marco Matucci-Cerinic ,&nbsp;Daniel E. Furst","doi":"10.1016/j.arcmed.2024.103072","DOIUrl":"10.1016/j.arcmed.2024.103072","url":null,"abstract":"<div><h3>Background</h3><p>Systemic sclerosis (SSc) is an autoimmune disease (AD), that receives less attention compared to rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and primary Sjögren's syndrome (pSS). This study aims to analyze transcriptional profiles and immune cell composition in peripheral blood mononuclear cells (PBMC) from SSc patients compared to other ADs.</p></div><div><h3>Methods</h3><p>RNA-seq data from 119 untreated patients (eight with SSc, 42 with RA, 41 with pSS, 28 with SLE) and 20 healthy controls were analyzed. Bioinformatics tools were employed to identify differentially expressed genes (DEGs), biological functions and immune cell profiles unique to SSc and shared with other ADs.</p></div><div><h3>Results</h3><p>1,148 DEGs were found in SSc, with upregulated genes associated with megakaryocyte processes and downregulated genes associated with neutrophil function and immune response.</p><p>DEGs, including <em>ALDH1A1</em> and <em>MEGF9</em>, were associated with neutropenia. Upregulated transcription factors (TFs) were linked to embryonic hematopoiesis and downregulated TFs were involved in leukocyte differentiation and immune regulation. Comparative analysis with other ADs revealed common pathogenic pathways, emphasizing megakaryocyte proliferation. Neutrophils count was significantly decreased in ADs (<em>p</em> &lt; 0.001) compared to healthy controls. Comparative analysis highlighted common pathways, particularly in megakaryocyte proliferation, and unique genes (<em>MEGF9, MMP8,</em> and KRT family members) in SSc, suggesting roles in neutrophil function, skin integrity, and fibrosis.</p></div><div><h3>Conclusions</h3><p>This study identifies dysregulated gene expression (KRT and <em>MMP8</em>) associated with neutrophil function and increased megakaryocytes in SSc, highlighting common patterns across autoimmune diseases. These findings offer new insights into the potential pathogenesis of SSc, and help to explore new targets for the treatment.</p></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 1","pages":"Article 103072"},"PeriodicalIF":4.7,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0188440924001243/pdfft?md5=0e2feb787f7209026a7fab5283e4b045&pid=1-s2.0-S0188440924001243-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142087404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Making and Selecting the Best Embryo in In vitro Fertilization","authors":"Rocío Nuñez-Calonge ,&nbsp;Nuria Santamaria ,&nbsp;Teresa Rubio ,&nbsp;Juan Manuel Moreno","doi":"10.1016/j.arcmed.2024.103068","DOIUrl":"10.1016/j.arcmed.2024.103068","url":null,"abstract":"<div><p>Currently, most assisted reproduction units transfer a single embryo to avoid multiple pregnancies. Embryologists must select the embryo to be transferred from a cohort produced by a couple during a cycle. This selection process should be accurate, non-invasive, inexpensive, reproducible, and available to <em>in vitro</em> fertilization (IVF) laboratories worldwide.</p><p>Embryo selection has evolved from static and morphological criteria to the use of morphokinetic embryonic characteristics using time-lapse systems and artificial intelligence, as well as the genetic study of embryos, both invasive with preimplantation genetic testing for aneuploidies (PGT-A) and non-invasive (niPGT-A). However, despite these advances in embryo selection methods, the overall success rate of IVF techniques remains between 25 and 30%. This review summarizes the different methods and evolution of embryo selection, their strengths and limitations, as well as future technologies that can improve patient outcomes in the shortest possible time. These methodologies are based on procedures that are applied at different stages of embryo development, from the oocyte to the cleavage and blastocyst stages, and can be used in laboratory routine.</p></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"55 8","pages":"Article 103068"},"PeriodicalIF":4.7,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142076317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Veiled Menace: The Contribution of Pollution to Endocrine Diseases","authors":"YASHENDRA SETHI ,&nbsp;SAMEER MEHTA ,&nbsp;NIRJA KAKA ,&nbsp;NEIL PATEL ,&nbsp;NIDHI UNIYAL","doi":"10.1016/j.arcmed.2024.103067","DOIUrl":"10.1016/j.arcmed.2024.103067","url":null,"abstract":"","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"56 1","pages":"Article 103067"},"PeriodicalIF":4.7,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142077464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Air Pollution on Neurological and Psychiatric Health","authors":"YASHENDRA SETHI,&nbsp;PRATIK AGARWAL,&nbsp;VIDHI VORA,&nbsp;SIDDHARTH GOSAVI","doi":"10.1016/j.arcmed.2024.103063","DOIUrl":"10.1016/j.arcmed.2024.103063","url":null,"abstract":"<div><p>Air pollution is a critical global issue with extensive implications beyond respiratory health, significantly affecting neurological and psychiatric disorders. Emerging evidence establishes a link between exposure to fine particulate matter (PM &lt; 2.5 µm), sulfur dioxide (SO₂), and nitrogen dioxide (NO₂) and heightened risks of dementia, Alzheimer's disease, schizophrenia, ADHD, stroke, Parkinson's disease, and multiple sclerosis. Mechanistic pathways include neuroinflammation, oxidative stress, microglial activation, cerebrovascular dysfunction, and blood-brain barrier disruption. Epidemiological studies indicate increased susceptibility among urban residents, particularly men, middle-aged individuals, and married persons, to the mental health impacts of air pollution. Additionally, socioeconomic factors, such as GDP per capita, access to health resources, green spaces, and sports facilities, modulate these health outcomes. Addressing this public health challenge necessitates stricter industrial emission controls, sustainable agricultural practices, promotion of cleaner energy sources, and incorporation of pollution exposure history into clinical assessments. Enhanced public awareness and interdisciplinary research are vital for mitigating the detrimental effects of air pollution on neurological and psychiatric health, ultimately striving for a cleaner and healthier environment for future generations.</p></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"55 7","pages":"Article 103063"},"PeriodicalIF":4.7,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141903914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Role of Reticulocyte Fluorescence for Late Red Blood Cell Transfusion in Very Low Birth Weight Infants","authors":"Serafina Perrone ,&nbsp;Valentina Dell'Orto ,&nbsp;Virginia Beretta ,&nbsp;Giuseppe De Bernardo ,&nbsp;Maurizio Giordano ,&nbsp;Chiara Petrolini ,&nbsp;Giovanni Boscarino ,&nbsp;Chiara Sodini ,&nbsp;Annachiara Titolo ,&nbsp;Federico Costa ,&nbsp;Susanna Maria Roberta Esposito","doi":"10.1016/j.arcmed.2024.103066","DOIUrl":"10.1016/j.arcmed.2024.103066","url":null,"abstract":"<div><h3>Background</h3><p>Nearly 58% of very low birth weight (VLBW) infants receive at least one red blood cell transfusion, which is not without risk. Reticulocyte fluorescence (RF) indicates the degree of cell maturation. The greater the fluorescence, the greater the immaturity of the reticulocytes.</p></div><div><h3>Aim</h3><p>To evaluate RF as a marker of reticulocyte maturity and to investigate its predictive value for transfusion requirement in VLBW infants.</p></div><div><h3>Methods</h3><p>Complete blood count was performed at 1, 7, 14, 21, and 28 d of age in 104 VLBW infants at the University Hospital of Parma. Iron supplementation was started at 15 d of life. The infants were divided into two groups: those who required transfusion after 28 d of life. (Tr) and those who did not (NTr).</p></div><div><h3>Results</h3><p>Twenty-seven of 104 newborns required a red blood cell transfusion after 28 d of life (Tr group). At 14 d of life, the percentage of high fluorescence reticulocyte (HFR) was significantly higher in the r group than in infants who did not receive any transfusion (NTr groups): 18.5 vs. 5%, <em>p</em> = 0.002. The ROC curve (AUC 74%) revealed an HFR cut-off value of 16.5% as a predictor of the need for red blood cell (RBC) transfusion.</p></div><div><h3>Conclusions</h3><p>Reticulocyte maturation at 14 d of life is clinically useful for estimating the qualitative impairment of erythropoiesis and predicts the risk of RBC transfusion in VLBW infants. The data suggest the need for tailored iron integration in VLBW infants to improve the quality of hematopoiesis and reduce the risk of blood transfusion.</p></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"55 7","pages":"Article 103066"},"PeriodicalIF":4.7,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141891221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atherogenic Combined Index: Validation of a Novel Predictive Lipid Biomarker for the Presence and Severity of Coronary Artery Disease","authors":"Kenan Toprak ,&nbsp;Mustafa Kaplangöray ,&nbsp;Mesut Karataş ,&nbsp;Ayten Dursun ,&nbsp;Yakup Arğa ,&nbsp;Mustafa Begenc Tascanov ,&nbsp;Asuman Biçer ,&nbsp;Recep Demirbağ","doi":"10.1016/j.arcmed.2024.103065","DOIUrl":"10.1016/j.arcmed.2024.103065","url":null,"abstract":"<div><h3>Background/Aim</h3><p>The balance between atherogenic and antiatherogenic lipid particles significantly influences coronary artery disease (CAD), as an imbalance may contribute to the development and progression of atherosclerosis, which affects the risk and severity of CAD. This study aims to introduce and validate the atherogenic combined index (ACI) as a novel lipid biomarker that, comprehensively assesses the balance between atherogenic and antiatherogenic particles in the blood to effectively reflect the cumulative atherogenic effect and its association with the presence and severity of CAD.</p></div><div><h3>Material and Methods</h3><p>In this cross-sectional study, 1,830 patients diagnosed with CAD and a total of 650 patients without CAD were included in the study cohort for comprehensive analysis and comparison. Based on the tertiles of the SYNTAX score (SS), three subgroups of patients with CAD were identified. ACI and other atherogenic indices were compared to predict the presence and severity of CAD.</p></div><div><h3>Results</h3><p>The levels of ACI and other non-traditional lipid markers levels were higher in the CAD group compared to the non-CAD group (<em>p</em> &lt;0.05, for all). ACI showed a good linear association with the SYNTAX score (<em>r</em> = 0.527; <em>p</em> &lt;0.001). The multivariate logistic regression model showed that ACI was an independent predictor of the presence (OR: 1.602, 95% CI: 1.509–1.701, <em>p</em> &lt;0.001) and severity (OR: 1.296, 95% CI: 1.243–1.351, <em>p</em> &lt;0.001) of CAD after adjustment for various confounders.</p></div><div><h3>Conclusion</h3><p>The results suggest that ACI may serve as a promising and stronger tool for predicting the presence and severity of CAD.</p></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"55 7","pages":"Article 103065"},"PeriodicalIF":4.7,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141891220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Effects of Exosomal miRNA-4731‐5p from Adipose Tissue-Derived Stem Cells on Human Glioblastoma Cells","authors":"Abouzar Babaei ,&nbsp;Amin Torabi Yazdi ,&nbsp;Reza Ranji ,&nbsp;Ensiyeh Bahadoran ,&nbsp;Shiva Taheri ,&nbsp;Farhad Nikkhahi ,&nbsp;Saied Ghorbani ,&nbsp;Ardeshir Abbasi","doi":"10.1016/j.arcmed.2024.103061","DOIUrl":"10.1016/j.arcmed.2024.103061","url":null,"abstract":"<div><h3>Background and aim</h3><p>Several microRNAs (miRNAs) are differentially expressed and serve as tumor suppressors in glioblastoma (GBM). The present study aimed to elucidate the function of exosomal microRNA‐4731-5p (miR-4731-5p) from adipose tissue-derived mesenchymal stem cells (AD-MSCs) in the activity of human GBM cell lines.</p></div><div><h3>Method</h3><p>First, GBM-related miRNAs, their expression, and potential target genes and cytokines of miR-4731-5p were identified using bioinformatic datasets. Subsequently, purified AD-MSCs were transfected with a miRNA-4731‐5p expression plasmid, and exosomes were isolated and characterized. Next, the transfection process was confirmed and the 50% inhibitory concentration (IC50) of the overexpressed exosomal miRNA-4731‐5p was inhibited for cancer cells. The probable anticancer action of exosomal miRNA-4731‐5p on U‐87 and U‐251 GBM cell lines was verified by flow cytometry, DAPI staining, cell cycle, real-time PCR, and wound healing assays.</p></div><div><h3>Results</h3><p>A concentration of 50 ng/mL of miRNA-4731-5p-transfected exosomes was the safe dose for anticancer settings. The results showed that the exosomal miR-4731-5p exerted an inhibitory effect on the cell cycle and migration and induced apoptosis in GBM cell lines by regulating the phosphoinositide-3-kinase-AKT (PI3K-AKT) and nuclear factor-kB (NF-kB) signaling pathways.</p></div><div><h3>Conclusion</h3><p>This study reveals that the expression of exosomal miRNA-4731-5p has favorable antitumor properties for the treatment of GBM cell lines and may be a fundamental therapeutic option for this type of brain tumor.</p></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"55 7","pages":"Article 103061"},"PeriodicalIF":4.7,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141891248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global prevalence of nonalcoholic fatty liver disease: an updated meta-analysis on 78 million population over 38 countries","authors":"Ehsan Amini-Salehi ,&nbsp;Negin Letafatkar ,&nbsp;Naeim Norouzi ,&nbsp;Farahnaz Joukar ,&nbsp;Arman Habibi ,&nbsp;Mona Javid ,&nbsp;Nazila Sattari ,&nbsp;Mehrdad Khorasani ,&nbsp;Ali Farahmand ,&nbsp;Shervin Tavakoli ,&nbsp;Behnaz Masoumzadeh ,&nbsp;Elaheh Abbaspour ,&nbsp;Sahand Karimzad ,&nbsp;Amir Ghadiri ,&nbsp;Gautam Maddineni ,&nbsp;Mohammad Javad Khosousi ,&nbsp;Niloofar Faraji ,&nbsp;Mohammad-Hossein Keivanlou ,&nbsp;Abinash Mahapatro ,&nbsp;Mohamad Amin Khajavi Gaskarei ,&nbsp;Sandeep Samethadka Nayak","doi":"10.1016/j.arcmed.2024.103043","DOIUrl":"10.1016/j.arcmed.2024.103043","url":null,"abstract":"<div><h3>Background</h3><p>Nonalcoholic fatty liver disease (NAFLD) is a global health challenge, with a rising rate in line with other metabolic diseases. We aimed to assess the global prevalence of NAFLD in adult and pediatric populations.</p></div><div><h3>Methods</h3><p>PubMed, Scopus and Web of Science databases were systematically searched up to May 2023. Heterogeneity was assessed using Cochran's Q test and <em>I</em>² statistics, and random-effects model was used for meta-analysis. Analyses were performed using STATA version 18.</p></div><div><h3>Results</h3><p>A total of 479 studies with 78,001,755 participants from 38 countries were finally included. The global prevalence of NAFLD was estimated to be 30.2% (95% CI: 28.7–31.7%). Regionally, the prevalence of NAFLD was as follows: Asia 30.9% (95% CI: 29.2–32.6%), Australia 16.1% (95% CI: 9.0–24.8%), Europe 30.2% (95% CI: 25.6–35.0%), North America 29% (95% CI: 25.8–32.3%), and South America 34% (95% CI: 16.9–53.5%). Countries with a higher human development index (HDI) had significantly lower prevalence of NAFLD (coefficient = –0.523, <em>p</em> = 0.005). Globally, the prevalence of NAFLD in men and women was 36.6% (95% CI: 34.7–38.4%) and 25.5% (95% CI: 23.9–27.1%), respectively. The prevalence of NAFLD in adults, adults with obesity, children, and children with obesity was 30.2% (95% CI: 28.8–31.7%), 57.5% (95% CI: 43.6–70.9%), 14.3% (95% CI: 10.3–18.8%), and 38.0% (95% CI: 31.5–44.7%), respectively.</p></div><div><h3>Conclusion</h3><p>The prevalence of NAFLD is remarkably high, particularly in countries with lower HDI. This substantial prevalence in both adults and children underscores the need for disease management protocols to reduce the burden.</p></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"55 6","pages":"Article 103043"},"PeriodicalIF":4.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Activity Prediction Modeling Based on a Combination of Growth Differentiation Factor 15 and Serum Biomarker Levels in Dermatomyositis and Polymyositis","authors":"Qiong Wu ,&nbsp;Wei Wang ,&nbsp;Ling Qiu,&nbsp;Wanchan Peng,&nbsp;Yunli Zhang,&nbsp;Jinfang Fu,&nbsp;Siyu Wu","doi":"10.1016/j.arcmed.2024.103058","DOIUrl":"10.1016/j.arcmed.2024.103058","url":null,"abstract":"<div><h3>Aims</h3><p>Growth differentiation factor 15 (GDF15) plays an important role in multiple inflammatory disorders. We aimed to analyze serum GDF15 levels in adult patients with idiopathic inflammatory myopathies (IIMs).</p></div><div><h3>Methods</h3><p>Serum GDF15 levels were measured in 179 adult patients with IIMs and 76 healthy controls (HCs). The association between GDF15 levels and disease variables was analyzed using Spearman's rank correlation. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the discriminatory ability of GDF15 and the GDF15-to-lymphocyte ratio (GLR). Machine learning methods were applied to build predictive models.</p></div><div><h3>Results</h3><p>GDF15 levels and GLR were significantly elevated in patients with adult IIMs than in HCs. Compared with patients in remission, both GDF15 and GLR were significantly higher in myositis patients in an active phase. GDF15 levels correlated positively with myositis disease activity indices and negatively correlated with lymphocyte and platelet counts. ROC curve analysis revealed that GDF15 levels and GLR outperformed muscle enzymes and distinguished well between patients with active disease and those in remission. Furthermore, even in the normal muscle enzyme group, GDF15 levels and GLR were also well-distinguished between patients with active disease and those in remission. Using machine learning, a logistic regression model of GDF15 combined with creatine kinase and lymphocyte count was constructed and had a reliable predictive value for disease activity.</p></div><div><h3>Conclusions</h3><p>GDF15, particularly GLR, was significantly correlated with disease activity in adult patients with IIMs. They could serve as useful biochemical markers for evaluating disease activity, monitoring disease progression, and guiding treatment in adult patients with IIMs.</p></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"55 7","pages":"Article 103058"},"PeriodicalIF":4.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary Patterns and Geriatric Syndromes in older Mexican adults: Analysis of the 2018-19 National Health and Nutrition Survey","authors":"Vanessa De la Cruz-Góngora ,&nbsp;Betty Manrique-Espinoza ,&nbsp;Aarón Salinas-Rodríguez ,&nbsp;Brenda Martinez-Tapia ,&nbsp;Mario Flores-Aldana ,&nbsp;Teresa Shamah-Levy","doi":"10.1016/j.arcmed.2024.103044","DOIUrl":"10.1016/j.arcmed.2024.103044","url":null,"abstract":"<div><h3>Background</h3><p>The study of dietary patterns in older adults (OA) and their association with geriatric syndromes (GS) is scarce in Latin America.</p></div><div><h3>Objective</h3><p>To describe the association of dietary patterns with GS in the Mexican older adult population, using data from the 2018-19 National Health and Nutrition Survey.</p></div><div><h3>Methods</h3><p>Dietary data were collected from 3,511 adults (≥60 years of age, both sexes) using a semi-quantitative food frequency questionnaire. Dietary patterns were derived by principal component analysis based on the consumption of 162 foods from 24 food groups. The GS studied were: frailty, depressive symptoms (DS), low appendicular skeletal muscle mass (ASMM); additionally, we studied inflammation (serum CRP&gt;5 mg/L). Logistic regression models were used.</p></div><div><h3>Results</h3><p>Four major dietary patterns were identified: a) “Western”, b) “Prudent”, c) “Soups”, and d) “Traditional”. The middle and higher tertiles of the “Prudent” pattern were associated with lower odds of DS (OR 0.71, <em>p</em> = 0.04; and OR 0.61, <em>p</em> = 0.008), respectively. The second tertile of the “Soups” pattern was associated with lower odds of low ASMM (OR 0.68, <em>p</em> = 0031) and inflammation (OR 0.58, <em>p</em> = 0.022). The highest tertile of the “Traditional” pattern was associated with low ASMM (OR 1.55, <em>p</em> = 0.008) and lower odds of inflammation (OR 0.69, <em>p</em> = 0.044). No association was found between the “Western” dietary pattern and GS.</p></div><div><h3>Conclusions</h3><p>Three of four major dietary patterns were associated with GS in older Mexican adults. Further studies are needed to address strategies to improve diet quality in this age group and its association with health and functional outcomes.</p></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":"55 6","pages":"Article 103044"},"PeriodicalIF":4.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}