西班牙12个地区男性精液质量差异的研究

IF 4.7 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Archives of Medical Research Pub Date : 2024-12-01 DOI:10.1016/j.arcmed.2024.103140

Rocío Núñez , Andrés Guijarro , Pablo Alberola , Nuria Santamaría , Mireia Poveda , Ada Mora , Marta Masip , Sofía Sánchez , Sara Alonso , Teresa Rubio , Inmaculada Barros , Paloma González , Sonia Gili , I. Santiago Álvarez

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引用次数: 0

摘要

目的本研究旨在评估西班牙12个不同地理位置接受生育能力评估的患者精液质量可能存在的差异。方法在西班牙不同地区的12个辅助生殖中心进行研究。研究人员分析了2336名寻求生育能力评估的男性的精液样本。精液参数——包括精液体积、精子浓度、活力、形态、活力和总活动精子数（TMS）——按地理位置进行比较。所有参数均采用标准化方法进行评估，并进行实验室间质量控制以确保一致性。结果各中心患者年龄差异无统计学意义(方差分析，p >；0.05)。然而，各中心在精液体积、精子浓度、总活动力和经颅磁刺激方面的差异有统计学意义（p分别为0.020、0.004、0.000和0.008）。阿斯图里亚斯男性的精子浓度（平均值：59.8±48.7 × 106精子/mL）、活动力（平均总活动力：54.3±20.7%）和TMS（平均值：101.2±107.5 × 10^6）最高，与其他地区相比差异有统计学意义。来自Cataluña、Almería和Málaga的患者遵循了这些指标。相比之下，格拉纳达男性的精子浓度和TMS最低(平均浓度：43.1±35.8 × 10^6个精子/mL；平均TMS: 43.1±34.6 × 10^6)，其次是阿利坎特和马德里。精子形态和活力在两个中心之间没有显著差异。结论由于所有精液参数均采用标准化方法进行评估，因此所观察到的地区间精液质量差异不太可能是由于实验室差异所致。

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Study of variations in semen quality in men from 12 geographical locations in Spain

Objective

This study aimed to evaluate possible variations in semen quality among patients undergoing fertility evaluation in 12 different geographical locations in Spain.

Methods

The study was conducted in 12 assisted reproduction centers located in different regions of Spain. Semen samples from 2,336 men seeking fertility assessment were analyzed. Seminal parameters—including semen volume, sperm concentration, motility, morphology, vitality, and total motile sperm count (TMS) were compared by geographic location. All parameters were evaluated using standardized methodologies, with interlaboratory quality controls to ensure consistency.

Results

No significant differences in patient age were found between centers (ANOVA, p > 0.05). However, statistically significant variations in semen volume, sperm concentration, total motility, and TMS were observed between the centers (p = 0.020, 0.004, 0.000, and 0.008, respectively). Men from Asturias exhibited the highest values for sperm concentration (mean: 59.8 ± 48.7 × 10⁶ sperm/mL), motility (mean total motility: 54.3 ± 20.7%), and TMS (mean: 101.2 ± 107.5 × 10^6), with statistically significant differences compared to other regions. Patients from Cataluña, Almería, and Málaga followed in these metrics. In contrast, men from Granada presented the lowest sperm concentration and TMS (mean concentration: 43.1 ± 35.8 × 10^6 sperm/mL; mean TMS: 43.1 ± 34.6 × 10^6), followed by individuals from Alicante and Madrid. No significant differences in sperm morphology or vitality were observed between centers.

Conclusion

Since all seminal parameters were assessed using standardized methodologies, the observed differences in semen quality between regions are unlikely to be due to laboratory variability.

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来源期刊

Archives of Medical Research 医学-医学：研究与实验

CiteScore

12.50

自引率

0.00%

发文量

审稿时长

28 days

期刊介绍： Archives of Medical Research serves as a platform for publishing original peer-reviewed medical research, aiming to bridge gaps created by medical specialization. The journal covers three main categories - biomedical, clinical, and epidemiological contributions, along with review articles and preliminary communications. With an international scope, it presents the study of diseases from diverse perspectives, offering the medical community original investigations ranging from molecular biology to clinical epidemiology in a single publication.