Archives of Osteoporosis最新文献

{"title":"Reference curves for trabecular bone score adjusted for soft tissue thickness in children and adolescents from Mexico City","authors":"Miguel Angel Guagnelli,&nbsp;Desiree Lopez-Gonzalez,&nbsp;Karen Hind,&nbsp;Enisa Shevroja,&nbsp;Didier Hans,&nbsp;Patricia Clark","doi":"10.1007/s11657-025-01595-4","DOIUrl":"10.1007/s11657-025-01595-4","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>This study proposes age- and sex-specific trabecular bone score (TBS) reference curves for Mexican children and adolescents. Using the latest software version, results highlight significant pubertal changes and provide reference data for assessing pediatric bone health, paving the way for a wider use of this technology in children and adolescents.</p><h3>Purpose</h3><p>Trabecular Bone Score (TBS) is a grey scale texture measure that correlates with bone microarchitecture derived from dual-energy X-ray absorptiometry (DXA). While extensively studied in adults, limited data exist for pediatric populations. This study aims to develop age- and sex-specific reference curves for TBS adjusted for abdominal soft tissue thickness in healthy children and adolescents from Mexico City.</p><h3>Methods</h3><p>This cross-sectional study reanalyzed data from 1552 healthy participants (5–18 years) who underwent lumbar spine DXA scans using Lunar iDXA and TBS iNsight 4.0 (Core Module 19.4.0), which accounts for soft tissue thickness. Generalized Additive Models for Location, Scale, and Shape (GAMLSS) were employed to construct smoothed percentile curves. TBS values were stratified by age, sex, and Tanner stage, with descriptive statistics and outlier exclusions.</p><h3>Results</h3><p>TBS showed distinct age- and sex-related trajectories, with steep increases during puberty. Girls demonstrated a sharper rise in TBS starting at age 9, peaking by age 16, while boys exhibited a more gradual increase starting at age 10–11, peaking by age 18. Differences were also observed between Tanner stages, with the most significant changes occurring from stages 2 to 3.</p><h3>Conclusion</h3><p>This study proposes the first TBS reference curves for Mexican children and adolescents using the latest software version. This data may prove to be a valuable tool for assessing bone health in pediatric populations. Yet further research to explore TBS’s utility in predicting bone fragility in pediatric population as well as its life-course trends.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12325490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144788143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal bone loss in the paretic leg and its contributing factors in individuals with chronic stroke: a 2-year prospective cohort study","authors":"Huixi Ouyang,&nbsp;Tiev Miller,&nbsp;Ling Qin,&nbsp;Michael T. C. Ying,&nbsp;Vivian W. Y. Hung,&nbsp;Thomas W. H. Leung,&nbsp;Marco Y. C. Pang","doi":"10.1007/s11657-025-01541-4","DOIUrl":"10.1007/s11657-025-01541-4","url":null,"abstract":"<div><h3>Summary</h3><p>Post-stroke fracture risk necessitates investigation of bone properties and contributing factors. The decline in paretic tibia failure load post-stroke was attributed to decreased trabecular bone density and thickness at 2-year follow-up. Less decline in bone strength was associated with better leg blood flow, walking speed, strength, and activity at baseline.</p><h3>Purpose</h3><p>To delineate long-term changes in distal tibia bone properties after stroke and identify their associated factors.</p><h3>Methods</h3><p>High-resolution peripheral quantitative computed tomography (HR-pQCT) scans of the bilateral distal tibia were performed in 46 chronic stroke participants (age, 60.4 ± 7.8 years; post-stroke onset, 6.3 ± 4.2 years) and 45 controls (age, 57.7 ± 6.3 years) at baseline and 2 years later. We measured the change in the estimated failure load (indicator of bone strength), volumetric bone mineral density (vBMD), geometry, and microstructure. Blood flow volume of the popliteal artery, muscle strength, sensory function, and gait speed were also assessed.</p><h3>Results</h3><p>In the paretic leg of stroke participants, a significant decline in estimated failure load was observed (− 3.39%, <i>p</i> &lt; 0.01), which was greater than that of the non-paretic side (− 1.93%, <i>p</i> &lt; 0.01) and controls (− 1.89 to − 2.18%, <i>p</i> &lt; 0.05). The deterioration in estimated failure load was accompanied by a decline in trabecular vBMD and thickness. Greater arterial blood flow, higher walking velocity, better muscle strength, and higher physical activity level at baseline at 2-year follow-up portended less decline in estimated failure load.</p><h3>Conclusions</h3><p>During the 2-year follow-up, there was a decline in estimated failure load of the paretic distal tibia among people with chronic stroke, attributed to a decreased trabecular density and thickness. Greater decline in estimated tibial bone strength was associated with lower arterial blood flow volume and motor function on the paretic side.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12325440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144788141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"External validation of FRISBEE 2-year and 5-year fracture prediction models in a fracture liaison service cohort","authors":"Tove T. Borgen,&nbsp;Cathrine Brunborg,&nbsp;Frede Frihagen,&nbsp;Lene B. Solberg,&nbsp;Camilla Andreasen,&nbsp;Wender Figved,&nbsp;Ellen M. Apalset,&nbsp;Jan-Erik Gjertsen,&nbsp;Trude Basso,&nbsp;Jens-Meinhard Stutzer,&nbsp;Lars Nordsletten,&nbsp;Erik F. Eriksen,&nbsp;Åshild Bjørnerem","doi":"10.1007/s11657-025-01516-5","DOIUrl":"10.1007/s11657-025-01516-5","url":null,"abstract":"<div><h3>Summary</h3><p>We externally validated the FRISBEE models of 2-year and 5-year fracture risk prediction in 517 women with index fractures. Both models overestimated the fracture risk. Recalibration of the FRISBEE models are needed before use in Norwegian women with recent fractures.</p><h3>Purpose</h3><p>We externally validated the Fracture Risk Brussels Epidemiological Enquiry (FRISBEE) groups’ 2-year and 5-year fracture risk models.</p><h3>Methods</h3><p>We included women above 50 years with a recent fracture from the consent-based part of the Norwegian Capture the Fracture Initiative study (NoFRACT). They had bone mineral density assessed and filled in a questionnaire including risk factors for fracture at baseline between October 2015 and December 2017. We calculated and validated the 2-year and 5-year fracture risk using the FRISBEE equation models.</p><h3>Results</h3><p>Of 517 women aged 65.5 ± 8.6 years with fractures, 94 (18%), 55 (11%), and 31 (6%) sustained a subsequent fracture of any type, major osteoporotic fractures (MOF), or central fracture, during 4.7 ± 1.3 years mean follow-up. The area under the receiver-operating curve (AUC) (95% confidence interval (CI)) for any type of fracture, MOF, and central fracture was 0.57 (0.51–0.63), 0.57 (0.46–0.67), and 0.65 (0.53–0.77), respectively, for the FRISBEE 2-year risk models and 0.57 (0.51–0.64), 0.58 (0.50–0.67), and 0.67 (0.57–0.76) for the FRISBEE 5-year risk models. The calibration slopes (with 95% CI) that compared observed vs. predicted probabilities for fracture across deciles of risk for any type of fracture, MOF, and central fracture were all low: 0.34 (0.02–0.64), 0.33 (− 0.09–0.74), and 0.61 (0.16–1.06), in the FRISBEE 2-year models, and 0.54 (0.13–0.95), 0.43 (0.05–0.80), and 0.69 (0.31–1.08), in the FRISBEE 5-year models.</p><h3>Conclusion</h3><p>Overall, the FRISBEE models overestimated both 2-year and 5-year fracture risk. Recalibration is needed before these models can be used in Norwegian women with recent fractures.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early transition from short-term romosozumab to antiresorptive therapies: analysis of 26 cases","authors":"Judith Everts-Graber,&nbsp;Serge Ferrari,&nbsp;Albrecht Popp,&nbsp;Magaly Hars,&nbsp;Mathias Wenger,&nbsp;Sven Oser,&nbsp;Ueli Studer,&nbsp;Christian Steiner,&nbsp;Hans-Rudolf Ziswiler,&nbsp;Gernot Schmid,&nbsp;Stephan Reichenbach,&nbsp;Thomas Lehmann,&nbsp;Olivier Lamy,&nbsp;Elena Gonzalez Rodriguez","doi":"10.1007/s11657-025-01598-1","DOIUrl":"10.1007/s11657-025-01598-1","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>This multicentre, retrospective case series analysed bone mineral density (BMD) changes in 26 patients who switched early from romosozumab (3–10 months) to antiresorptives. BMD gains over 12 months were similar to those in patients (<i>n</i> = 99) completing the full 12-month course.</p><h3>Background</h3><p>Romosozumab is typically administered for a duration of 12 months before transitioning to antiresorptive therapies. This study analysed the bone mineral density (BMD) changes of patients who were prematurely switched to an antiresorptive regimen.</p><h3>Methods</h3><p>This multicentre, retrospective case series investigated the BMD response to romosozumab administered for 3 to 10 months, followed by subsequent antiresorptive therapy, across four bone centres in Switzerland. BMD measurements at the lumbar spine, total hip and femoral neck were conducted at the initiation of romosozumab and again 12 months later. The study compared the BMD changes in patients who received short-term romosozumab with those in a cohort of patients who completed the full 12-month course.</p><h3>Results</h3><p>Twenty-six patients (25 postmenopausal women and one man, median age 73 years [interquartile range: 65, 81]) were enrolled from February 2022 to December 2024. They received a median of six romosozumab injections (range: 3 to 10) and were prematurely switched to antiresorptives (14 to denosumab, 11 to zoledronate and one to alendronate) due to possible side effects or adverse events. Over 12 months, BMD increased by 13.5% [8.6, 16.6] at the lumbar spine, 2.9% [0.3, 7.3] at the total hip and 3.2% [0.4, 7.8] at the femoral neck, without significant differences compared with the cohort of 99 patients who received 12 months of romosozumab therapy. In both the short- and full-duration romosozumab treatment groups, significantly lower BMD responses were observed in patients who were pretreated with antiresorptives compared with those who were treatment naïve.</p><h3>Conclusion</h3><p>In patients who underwent an early switch from romosozumab to antiresorptive therapy, BMD responses during the first year were similar to those in patients who completed the full 12-month romosozumab treatment. However, the subsequent changes in BMD, when all patients are receiving antiresorptive therapy, remain to be determined.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of exercise modalities on bone health: a meta-analysis of aerobic, resistance, and combined training on bone mineral density in postmenopausal women","authors":"Keyvan Hejazi,&nbsp;Gholam Rasul Mohammad Rahimi,&nbsp;Martin Hofmeister","doi":"10.1007/s11657-025-01594-5","DOIUrl":"10.1007/s11657-025-01594-5","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>The prevalence of osteoporosis, particularly among the elderly population and postmenopausal women (PMW), remains a significant public health concern. Women aged 50 to 60 years are especially vulnerable to osteoporosis-related bone loss, emphasizing the need for preventative measures and early intervention.</p><h3>Purpose</h3><p>This systematic review and meta-analysis aimed to evaluate the impact of aerobic, resistance, and combined training on bone mineral density (BMD) in PMW aged 50 to 60 years.</p><h3>Methods</h3><p>A systematic search of six databases (Web of Science, Embase, Cochrane, PubMed, Google Scholar, and Scopus) was conducted. The review was registered in PROSPERO (CRD42024569040). Risk of bias was assessed using the Cochrane RoB 2 tool. A random-effects model was used to calculate mean differences (MDs) and 95% confidence intervals (CIs).</p><h3>Results</h3><p>Forty studies with 2,230 participants were included. All exercise modalities significantly improved BMD at the lumbar spine (MD = 0.02 g/cm²; p &lt; 0.001), total hip (MD = 0.01 g/cm²; p &lt; 0.001), femoral neck (MD = 0.01 g/cm²; p &lt; 0.001), trochanter (MD = 0.02 g/cm²; p &lt; 0.001), and total body (MD = 0.00 g/cm²; p = 0.002).</p><h3>Conclusion</h3><p>Regular exercise, particularly combined aerobic and resistance training, is an effective non-pharmacological strategy to mitigate bone loss and promote skeletal health in PMW.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteoporotic vertebral compression fracture in patients with childhood-onset lupus nephritis: prevalence and risk factors","authors":"Pornpimol Rianthavorn,&nbsp;Kamonwan Ueapanyaporn,&nbsp;Supatporn Tepmongkol,&nbsp;Nuanpan Penboon,&nbsp;Noppachart Limpaphayom","doi":"10.1007/s11657-025-01590-9","DOIUrl":"10.1007/s11657-025-01590-9","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>Vertebral fractures (VF) can occur due to childhood-onset lupus nephritis (cLN), which needs long-term use of immunosuppressants that affect bone health. This study found VF in 26.7% of cLN patients. Risk factors included low lumbar spine BMD<i> Z</i>-scores and high disease activity (SLEDAI-2K ≥ 20). Bone-strengthening and disease management strategies are important.</p><h3>Purpose</h3><p>Pediatric vertebral fracture (VF) may occur under conditions that lead to decreased bone mass. Childhood-onset lupus nephritis (cLN) requires treatment with glucocorticoids and immunosuppressants. This study aimed to determine the prevalence of and risk factors for VF in patients with cLN.</p><h3>Methods</h3><p>Patients with cLN who received glucocorticoids for more than 12 months underwent bone mineral density (BMD) evaluation and vertebral fracture assessment (VFA) via DXA scanning. Lupus disease activity was determined with the SLE Disease Activity Index 2000 (SLEDAI-2K), and scores ≥ 20 were classified as very high. Patients were classified based on the degree of vertebral compression using the Genant grading into two groups: VF (VFA &gt; 20%) and no VF. Logistic regression was conducted to identify risk factors for VF.</p><h3>Results</h3><p>Seventy-five patients (67 females, 89%) were enrolled. The average age at diagnosis was 11.5 ± 2.2 years. The mean duration of cLN was 7.9 ± 5.8 years. Twenty patients (26.7%) had VF and 11 (55%) had multiple VFs. The median VFA was 20%, with an anterior compression predominance (84%). A logistic regression model identified two risk factors: a low lumbar spine BMD <i>Z</i>-score (OR 0.48, 95% CI 0.25–0.89, <i>P</i> = 0.02) and a very high SLEDAI-2K score (OR 20.38, 95% CI 1.60–257.89, <i>P</i> = 0.02).</p><h3>Conclusion</h3><p>Multiple VFs were prevalent in patients with cLN. The risk of VF increased by 48% with a one-unit decrease in the BMD <i>Z</i>-score and by 20 times with a very high SLEDAI-2K score. A strategy to maintain bone strength and control disease activity should be implemented in patients with cLN.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using probiotic supplementation to support bone health in postmenopausal women: a randomized, double-blind, parallel, placebo-controlled, multi-center study","authors":"Jenalyn L. Yumol,&nbsp;Sylvie Binda,&nbsp;Varuni Nagulesapillai,&nbsp;Renu Bhardwaj,&nbsp;Wendy E. Ward","doi":"10.1007/s11657-025-01589-2","DOIUrl":"10.1007/s11657-025-01589-2","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>Studies using rodent models have demonstrated the ability for probiotics to attenuate estrogen-related bone loss, but findings in humans are limited. Postmenopausal women consuming a novel combination of bacteria strains as a probiotic supplement demonstrated no changes in bone health outcomes.</p><h3>Purpose</h3><p>This study determined if a probiotic supplement could attenuate the loss of femoral neck bone mineral density (BMD) and assessed its effect on fracture risk and markers of bone cell activity.</p><h3>Methods</h3><p>Seventy-two postmenopausal women (40–59 years) were randomized to a daily probiotic supplement or placebo for 48 weeks. Femoral neck BMD was assessed at weeks 0 and 48 using DXA along with fracture risk using the FRAX® assessment tool. Serum procollagen type 1 N-terminal propeptide (P1NP), bone-specific alkaline phosphatase (BALP), cross-linked C-telopeptide of type I collagen (CTx), and osteocalcin (OC) were analyzed at weeks 0, 12, 24, and 48.</p><h3>Results</h3><p>There was no significant time by treatment interaction (<i>p</i> &gt; 0.05) for femoral neck BMD or fracture risk. Independent of treatment, femoral neck BMD decreased (<i>p</i> = 0.034), while risk of hip (<i>p</i> = 0.003) and major osteoporotic fracture (<i>p</i> = 0.044) increased. There was no mean difference in bone marker levels between groups from baseline to endpoint. These findings align with the lack of difference in BMD and fracture risk at the end of study.</p><h3>Conclusion</h3><p>Probiotics did not alter BMD or fracture risk, as supported by bone cellular activity that was similar to the placebo group by the end of study.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12296836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acceptability of self-completion versus face-to-face use of a vertebral fragility fracture clinical decision tool for use in older people with back pain in the UK","authors":"Tanzeela Y. Khalid,&nbsp;Wendy Wilmott,&nbsp;Clare Shere,&nbsp;Tim J. Peters,&nbsp;Sarah Drew,&nbsp;Zoe Paskins,&nbsp;Emma M. Clark","doi":"10.1007/s11657-025-01586-5","DOIUrl":"10.1007/s11657-025-01586-5","url":null,"abstract":"<div><h3>Summary</h3><p>This study tested the agreement between self-completion and face-to-face completion of a vertebral fracture clinical decision tool called Vfrac in order to make an evidence-based recommendation of how Vfrac should be used for future research or clinical applications. Findings confirmed that it is necessary to take the physical measurements face-to-face.</p><h3>Background</h3><p>Around 12% of older adults have vertebral fragility fractures but fewer than one-third are diagnosed. Vfrac is a vertebral fracture screening tool developed to help clinicians identify which patients are at a high risk of having a vertebral fracture, so they can be referred for a spinal radiograph. The aim of this work was to assess the agreement between self-completion and face-to-face use of Vfrac and determine patient preference for use.</p><h3>Methods</h3><p>Adults aged &gt; 65 years who had experienced back pain in the last 4 months were invited to self-complete Vfrac and have Vfrac completed face-to-face with a healthcare professional. Agreement between low risk or high risk Vfrac scores from self-completion and face-to-face assessment was represented by Cohen’s kappa; agreement in scores was also assessed between fully face-to-face and hybrid completion of Vfrac where only physical measurements are taken face-to-face and the rest self-completed. Data on satisfaction, ease of use and preference for use was also collected.</p><h3>Results</h3><p>Data from 76 participants including 58 men and 18 women who both self-completed Vfrac and had Vfrac completed face-to-face was used to compare agreement in Vfrac scores. The mean age of participants was 76.4 years (range 65–92). There was moderate agreement in Vfrac scores (kappa 0.53; 95% confidence interval 0.31–0.75) between self-completed and face-to-face completed Vfrac with varied scores for 11 participants out of 76 (14.5%).There was only slight agreement (kappa &lt; 0.2) for each of the three physical measurements between self-completed and face-to-face completed Vfrac. A moderate level of agreement (kappa 0.51) was also observed between fully face-to-face and hybrid completion of Vfrac. Thirty-seven percent of participants had no strong preference for how Vfrac should be completed, 33% preferred self-completion, and 30% preferred face-to-face completion.</p><h3>Conclusions</h3><p>This study has resulted in the recommendation that future use of this tool should include completion of the physical measurements by a healthcare professional face-to-face, combined with the option of patients either self-completing the questions at home before their appointment or face-to-face at the time of the physical measurements, depending on individual preference.</p><h3>Trial registration</h3><p>ISRCTN12150779.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12287210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding osteoporosis: knowledge and practices of postmenopausal women in Saudi Arabia","authors":"Fatmah Alsharif,&nbsp;Fathia Khamis Kassem,&nbsp;Hamamah Murdi Alzahrani,&nbsp;Rufaidah Abdulkareem Rubehan,&nbsp;Shahad Ali Baarma,&nbsp;Abrar Hussain Alsaggaf,&nbsp;Wedad Almutairi,&nbsp;Mai Yassen,&nbsp;Ohood Felemban,&nbsp;Khulud Abudawood","doi":"10.1007/s11657-025-01593-6","DOIUrl":"10.1007/s11657-025-01593-6","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>This study examined osteoporosis knowledge and preventive practices among 375 postmenopausal women in Jeddah, Saudi Arabia, using a validated survey. Younger age and more children were linked to higher knowledge, but no demographic factors influenced practices. Results highlight a gap between awareness and action, emphasizing the need for targeted public health interventions.</p><h3>Background</h3><p>Osteoporosis is a progressive bone disease, common among postmenopausal women, and a major cause of fractures and disability. Despite its high prevalence in Saudi Arabia, early detection and prevention efforts remain inadequate. </p><h3>Purpose</h3><p>This study assessed osteoporosis-related knowledge and preventive practices among self-identified as postmenopausal woman in Jeddah and identified demographic predictors influencing these outcomes.</p><h3>Methods</h3><p>A cross-sectional survey was conducted between February and April 2023 using an online, self-administered questionnaire distributed via WhatsApp and X (formerly Twitter). The instrument included the validated Osteoporosis Knowledge Assessment Tool (OKAT) and a custom preventive practices scale. A convenience sample of 375 women aged 45 years and older participated. Generalized linear models were used to explore associations between demographic variables and knowledge and practice scores.</p><h3>Results</h3><p>The mean knowledge score was 22.23, and the mean preventive practices score was 14.88. Women aged 45–55 years had significantly higher knowledge scores than those aged 66–75 years (β = 0.29; 95% CI: 0.045–0.54; p = 0.02). Additionally, a greater number of children positively predicted knowledge levels (β = 0.04; 95% CI: 0.02–0.06; p &lt; 0.0001). However, no demographic factors, including age and reproductive history, were significantly associated with preventive practices.</p><h3>Conclusion</h3><p>A clear gap exists between knowledge and action in osteoporosis prevention. While certain demographics are linked to better awareness, they do not drive preventive behavior. Broader, targeted public health interventions are needed to bridge this gap and enhance osteoporosis prevention strategies among Saudi women.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opportunistic computed tomography (CT) assessment of osteoporosis in patients undergoing transcatheter aortic valve replacement (TAVR)","authors":"Michael Paukovitsch,&nbsp;Tom Fechner,&nbsp;Dominik Felbel,&nbsp;Johannes Moerike,&nbsp;Wolfgang Rottbauer,&nbsp;Steffen Klömpken,&nbsp;Horst Brunner,&nbsp;Christopher Kloth,&nbsp;Meinrad Beer,&nbsp;Anjany Sekuboyina,&nbsp;Dominik Buckert,&nbsp;Jan S. Kirschke,&nbsp;Nico Sollmann","doi":"10.1007/s11657-025-01579-4","DOIUrl":"10.1007/s11657-025-01579-4","url":null,"abstract":"","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12271236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}