Archives of Osteoporosis最新文献

{"title":"Is surgeon assessed bone quality during total knee arthroplasty a valid tool to diagnose osteoporosis?","authors":"Adit R. Maniar,&nbsp;Akshay Nayak,&nbsp;Arpit Bavaskar,&nbsp;Vishal Raina,&nbsp;Ashwini Khokhar,&nbsp;Rajesh N. Maniar","doi":"10.1007/s11657-025-01531-6","DOIUrl":"10.1007/s11657-025-01531-6","url":null,"abstract":"<div><h3>Summary</h3><p>Osteoporosis continues to have a high prevalence amongst people undergoing total knee arthroplasty (TKA). The surgeon assessed intraoperative bone quality using a visual analogue scale has a strong correlation with bone mineral density. Surgeon assessment of bone quality has a high specificity(100%) and positive predictive value(100%) in diagnosing osteoporosis and osteopenia.</p><h3>Background</h3><p>Patients undergoing TKA have a high prevalence of osteoporosis. Our aim is to study (a) the correlation of intraoperative surgeon assessed bone quality with bone mineral density(BMD) as measured by dual‐energy x-ray absorptiometry(DEXA) and (b) the diagnostic strength of intraoperative surgeon assessment of bone quality in diagnosing osteoporosis and osteopenia, in patients undergoing TKA.</p><h3>Methods</h3><p>We prospectively recruited 31 patients undergoing TKA. Patients were classified into normal, osteopenia or osteoporosis based on preoperative DEXA. Intraoperatively, the senior surgeon by visual and tactile assessment, graded the bone quality(BQ) using a visual analogue scale(VAS) from 0 to 10, with 10 being the strongest bone. Using the VAS score, we classified patients as normal(≥ 8), osteopenia(5–7) and osteoporosis(≤ 4).</p><h3>Results</h3><p>The Spearman’s rho correlation between BMD and VAS was 0.954.(<i>p</i> &lt; 0.001). VAS &lt; 8 to diagnose osteopenia and osteoporosis had a sensitivity of 70.83%, specificity of 100%, positive predictive value of 100% and diagnostic accuracy of 77.42%(<i>p</i> = 0.001). VAS ≤ 4 to diagnose osteoporosis had a sensitivity of 71.43%, specificity of 100%, positive predictive value of 100% and diagnostic accuracy of 93.55%(<i>p</i> &lt; 0.001).</p><h3>Conclusion</h3><p>The surgeon assessed intraoperative bone quality using a VAS during TKA has a strong correlation with the gold standard BMD as measured by DEXA scan. VAS ≤ 4 can help diagnose osteoporosis, allowing surgeons to augment implant fixation with stem and cement as well as guide osteoporosis treatment postoperatively. VAS &lt; 8 can identify osteopenic or osteoporotic bone, thus allowing the surgeon to better identify weaker bone and help titrate implant choice.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of hospital-initiated bone densitometry with hospitalization for fragility fracture at Lille University Hospital among adults with chronic obstructive pulmonary disease","authors":"Eléonore Heddebaut,&nbsp;Pierre Balayé,&nbsp;Emeline Cailliau,&nbsp;Olivier Le Rouzic,&nbsp;Cécile Philippoteaux,&nbsp;Julien Paccou","doi":"10.1007/s11657-025-01534-3","DOIUrl":"10.1007/s11657-025-01534-3","url":null,"abstract":"<div><h3>Summary</h3><p>A retrospective study was conducted to calculate the cumulative incidence of hospital-initiated bone densitometry, in the year following hospitalization for fragility fracture in patients with chronic obstructive pulmonary disease. This cohort study demonstrated low rates of hospital-initiated bone densitometry with a 1-year cumulative incidence of 22.6%.</p><h3>Background</h3><p>Osteoporosis is one of the most frequent comorbidities in chronic obstructive pulmonary disease (COPD) patients. A study was conducted to assess the management of osteoporosis in COPD patients using the INCLUDE health data warehouse.</p><h3>Objectives</h3><p>The primary objective was to calculate the cumulative incidence of hospital-initiated bone densitometry, in the year following hospitalization for fragility fracture in COPD patients.</p><h3>Patients and methods</h3><p>A retrospective, monocentric, observational study was conducted at Lille University Hospital with patients identified from January 2013 to December 2021. Patients with COPD, aged 40 or over, and hospitalized for a fragility fracture according to the ICD-10 classification were included. Bone densitometry was indexed according to French Common Procedures Classification (CCAM) acts by INCLUDE.</p><h3>Results</h3><p>A total of 365 patients (~ 60% male, mean age 73.5 ± 12.3 years, and median Charlson score 2.0 (1.0; 4.0)) were included. Hospitalization units for fractures were orthopedics (<i>n</i> = 168), geriatrics (<i>n</i> = 46), rheumatology (<i>n</i> = 45), pneumology (<i>n</i> = 24), and others (<i>n</i> = 82). A total of 499 fractures were identified, most of them severe (hip (36.4%), vertebrae (30.1%), proximal humerus (11.5%), pelvis (10.7%), etc.). During the first year, 69 patients (18.9%) died, and 81 underwent hospital-initiated bone densitometry. The cumulative incidence of bone densitometry in the 1st year was 22.6% [CI 95% 18.3–27.1%]. Independent determinants of performing bone densitometry were female gender, low Charlson score, hospitalization in rheumatology, and vertebral fracture(s).</p><h3>Conclusion</h3><p>The cumulative incidence of hospital-initiated bone densitometry, within 1 year of hospitalization for a fragility fracture in COPD patients was relatively low.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11657-025-01534-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for non-vertebral fractures in community-dwelling elderly: a 10-year follow-up study in New Zealand","authors":"Haixia Liu,&nbsp;Zhenqiang Wu,&nbsp;Robert Scragg","doi":"10.1007/s11657-025-01530-7","DOIUrl":"10.1007/s11657-025-01530-7","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>This 10-year study of 5000 + adults aged 50–84 found 20% experienced non-vertebral fractures. Higher risk was linked to female sex, older age, European ethnicity, lower education, living alone, alcohol use, prior falls/fractures, osteoporosis, arthritis, and antidepressants. Targeting modifiable factors (living arrangements, alcohol, antidepressants) could reduce fracture burden cost-effectively in older adults.</p><h3>Background</h3><p>Although there has been extensive research on non-vertebral fractures, their risk factors remain incompletely understood. This study aimed to examine risk factors associated with non-vertebral fractures through a longitudinal examination of a community-dwelling cohort.</p><h3>Methods</h3><p>This was a follow-up of participants recruited from family practices into a randomized trial of vitamin D supplementation and interviewed between 2011 and 2012, with follow-up until 2022. The outcome was the first non-vertebral fracture during the follow-up period, as identified from hospital events and insurance claims for fractures. Candidate risk factors were selected using a domain-based approach, and Cox models were employed to estimate adjusted hazard ratios (HRs).</p><h3>Results</h3><p>The analysis comprised 5108 participants aged 50–84 years. Of these, 83% were of European/other ethnicity. A substantial proportion reported living with non-family members or living alone (20.5%), engaging in daily drinking (21.6%), or using antidepressants (11.9%). Over a median 10-year follow-up, 1016 participants (20%) experienced non-vertebral fractures. In the multivariable model, several factors were related to higher risk of non-vertebral fracture, including females (HR = 1.53), aged 80–84 years (HR = 1.47), European/other ethnicity, primary school education (HR = 1.65), living with non-family members (HR = 1.47) or living alone (HR = 1.29), daily alcohol drinking (HR = 1.51), history of falls (HR = 1.59) or fractures (HR = 1.43), osteoporosis (HR = 1.95), and arthritis (HR = 1.20), and dispensing of antidepressants (HR = 1.52) and antiarrhythmic medications (HR = 1.51).</p><h3>Conclusion</h3><p>Non-vertebral fractures are prevalent among older adults, with several prevalent and potentially modifiable risk factors identified, such as living situation, drinking habits, and antidepressant dispensing. Further exploration of these factors’ causality and the implementation of public health interventions targeting them, could yield significant benefits and cost-effectively reduce the burden of fractures.</p><h3>Trial registration</h3><p>This study was registered with the Australian New Zealand Clinical Trials Registry (ACTRN12611000402943).</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11657-025-01530-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modified versus conventional percutaneous kyphoplasty for osteoporotic vertebral compression fracture treatment: a systematic review and pilot meta-analysis","authors":"Yihao Tao,&nbsp;Zhouqi Guo,&nbsp;Liying Miao,&nbsp;Hekai Shi,&nbsp;Ye Zhang,&nbsp;Wu Wang","doi":"10.1007/s11657-025-01522-7","DOIUrl":"10.1007/s11657-025-01522-7","url":null,"abstract":"<div><h3>Purpose</h3><p>This study compares the safety and clinical effectiveness of modified percutaneous kyphoplasty (PKP) approaches (transverse process-pedicle or extrapedicular) with the conventional transpedicular approach for treating osteoporotic vertebral compression fractures.</p><h3>Methods</h3><p>We searched various databases, including PubMed, Cochrane Library, Web of Science, Embase, and Scopus. Safety outcomes included operative time, radiation dose, injected cement volume, and cement leakage rate, while efficacy outcomes were the Visual Analogue Scale (VAS), Oswestry Disability Index (ODI), Cobb’s angle, and vertebral body height. The quality of cohort studies was assessed using the Newcastle–Ottawa Score, and a meta-analysis was conducted using Review Manager 5.4.</p><h3>Results</h3><p>Nine high-quality cohort studies involving 1,187 patients were included. Compared to conventional PKP, the modified approach resulted in significantly shorter operative time (mean differences [MD]: − 11.72, 95% confidence interval [CI]: − 16.56 to − 6.88, <i>p</i> &lt; 0.00001), lower radiation dose (standardized mean differences: − 2.21, 95% CI: − 2.96 to − 1.45, <i>p</i> &lt; 0.00001), reduced injected cement volume (MD: − 0.89, 95% CI: − 1.58 to − 0.21, <i>p</i> = 0.01), and a lower cement leakage rate (MD: 0.58, 95% CI: 0.41–0.80, <i>p</i> = 0.001). However, both groups had no significant differences in VAS score, ODI score, Cobb’s angle, or vertebral body height.</p><h3>Conclusion</h3><p>No significant difference in pain relief or functional improvement was observed between modified and conventional PKP. However, modified PKP has a shorter operative time, a lower radiation dose, a lower injected cement volume, and a lower cement leakage rate than conventional PKP. These findings suggest that modified PKP is safer, with similar therapeutic outcomes to conventional PKP.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of osteoporosis virtual training course for general practitioners","authors":"Elahe Hesari,&nbsp;Fatemeh Hajivalizadeh,&nbsp;Mahnaz Sanjari,&nbsp;Kazem Khalagi,&nbsp;Noushin Fahimfar,&nbsp;Maryam Amini,&nbsp;Mahbobe Darman,&nbsp;Maryam Aalaa,&nbsp;Pardis Zarepour,&nbsp;Mohammad Javad Mansourzadeh,&nbsp;Sepideh Hajivalizadeh,&nbsp;Donya Sadeghi,&nbsp;Afshin Ostovar,&nbsp;Bagher Larijani","doi":"10.1007/s11657-025-01532-5","DOIUrl":"10.1007/s11657-025-01532-5","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>This study evaluated the impact of a virtual training program on osteoporosis management for general practitioners. Among 498 participants, knowledge scores significantly increased from 38 to 83 (<i>P</i> &lt; 0.001). The findings highlight the effectiveness of targeted education in enhancing practitioners' understanding, ultimately improving patient care and reducing healthcare costs.</p><h3>Purpose</h3><p>Osteoporosis is a widespread global health concern. Training the general practitioners with updated treatment strategies can notably lessen patient discomfort (fracture and mobility limitation) and costs. So, this study aimed to assess the impact of a training course on osteoporosis management knowledge targeted at general practitioners.</p><h3>Methods</h3><p>A quasi-experimental study was conducted to train general practitioners about Osteoporosis. The study utilized a virtual education program accessible online and contained five key aspects of osteoporosis management. The impact of this program was evaluated by comparing pre-test and post-test scores across all 5 modules. Evaluation of Electronic Modules questionnaire was used to assess the quality of the osteoporosis virtual course. A linear regression analysis explored factors influencing physicians’ knowledge percent change in 5 modules.</p><h3>Results</h3><p>A total of 498 general practitioners participated in a virtual course on osteoporosis management. The average participant age was 35, and over 70% were women. The mean score for all five modules increased significantly, from 38 to 83, more than double the original score (<i>P</i> &lt; 0.001). The analysis revealed that in Module 3 (Clinical Management), younger participants attained significantly higher post-test scores (<i>β</i>, − 0.28; 95% CI, − 0.55, − 0.01; <i>P</i>, 0.039). Also, most participants agreed or strongly agreed that the system is high-quality, offers valuable information, and services, and is both user-friendly and beneficial.</p><h3>Conclusion</h3><p>The virtual training course on osteoporosis management principles notably improved the participants’ knowledge.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and effectiveness of a digital voice assistant for improving anti-osteoporosis medication adherence, and osteoporosis knowledge and attitudes, in postmenopausal women with osteoporosis: A 12-month randomised controlled trial","authors":"Melkamu Tamir Hunegnaw,&nbsp;Jakub Mesinovic,&nbsp;Paul Jansons,&nbsp;Elena S. George,&nbsp;Belinda De Ross,&nbsp;Nicole Kiss,&nbsp;Peter R. Ebeling,&nbsp;Robin M. Daly,&nbsp;Eugene Gvozdenko,&nbsp;David Scott","doi":"10.1007/s11657-025-01529-0","DOIUrl":"10.1007/s11657-025-01529-0","url":null,"abstract":"<div><h3>Summary</h3><p>Digital voice assistants (DVAs) are feasible for delivering a digital health intervention designed to improve osteoporosis self-management in postmenopausal women with osteoporosis. However, the DVA intervention did not improve anti-osteoporosis drug adherence, nor did it enhance osteoporosis knowledge or attitudes in this population.</p><h3>Purpose</h3><p>To determine feasibility and effectiveness of a digital voice assistant (DVA) intervention for improving anti-osteoporosis medication adherence, and osteoporosis knowledge and attitudes, in postmenopausal women with osteoporosis.</p><h3>Methods</h3><p>This 12-month single-blinded, randomised controlled trial included 50 postmenopausal women with osteoporosis randomised to DVA (N = 25) or control (N = 25) for 6 months, followed by a 6-month follow-up period. DVA participants received an Amazon Alexa device that delivered osteoporosis education videos, medication reminders and interactive quizzes. Control participants received emails with links to osteoporosis information. Anti-osteoporosis medication possession ratio (MPR; acceptable adherence defined as ≥ 0.8) was determined using Pharmaceutical Benefits Schedule data. Osteoporosis knowledge was measured using the Osteoporosis Knowledge Assessment Tool (OKAT) and medication attitudes were measured using the Adherence Evaluation of Osteoporosis Treatment (ADEOS-12) questionnaire.</p><h3>Results</h3><p>The mean ± SD age of participants was 64.3 ± 6.1 years and 6-month DVA intervention adherence (number of DVA sessions accessed) was 79.5% (95%CI: 73.9, 84.9). The proportion of participants with acceptable 12-month MPRs was similar between groups (control: 86.4% [95%CI: 77.0, 93.6]; DVA: 95.0% [95%CI: 88.4, 100.0], <i>P</i> = 0.34). Mean OKAT scores improved in both groups after both 6- and 12 months, but there were no significance between groups. Changes in mean ADEOS-12 scores did not differ between baseline and 6 months in DVA compared to control (0.61 [95%CI: − 0.80, 2.03]) but worsened post-intervention from 6 to 12 months (net difference: − 1.42 [95%CI: − 2.80, − 0.06]).</p><h3>Conclusions</h3><p>This DVA-delivered intervention achieved good adherence but did not improve medication adherence, osteoporosis knowledge, or attitudes compared with control. Future studies should target populations with poor adherence to anti-osteoporosis medication.\u0000</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11657-025-01529-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breaking the silence: AI’s contribution to detecting vertebral fractures in opportunistic CT scans in the elderly—a validation study","authors":"Anna Spångeus,&nbsp;Tomas Bjerner,&nbsp;Maria Lindblom,&nbsp;Christoph Götz,&nbsp;Allan Hummer,&nbsp;Christoph Salzlechner,&nbsp;Mischa Woisetschläger","doi":"10.1007/s11657-025-01524-5","DOIUrl":"10.1007/s11657-025-01524-5","url":null,"abstract":"<div><h3>Summary</h3><p>Vertebral fractures frequently go undetected in clinical practice. AI-assisted detection on CT scans demonstrates considerable promise, with a sensitivity of 86% and a specificity of 99%. The performance varied based on sex, and CT kernel, showing superior results in females and in scans using non-bone kernel protocols.</p><h3>Purpose</h3><p>Vertebral fractures (VFs) are highly underdiagnosed, necessitating the development of new identification methods for opportunistic screening in computed tomography (CT) scans. This study validated an AI algorithm (ImageBiopsy Lab [IBL], FLAMINGO) for detecting VFs in a geriatric cohort, with various subgroup analyses including different CT protocols.</p><h3>Methods</h3><p>The performance of the AI in detecting VFs was compared to assessments by two experienced radiologists. A total of 246 thoracic or abdominal CT scans, primarily conducted for purposes other than skeletal examination, were included in the study.</p><h3>Results</h3><p>The patients had a mean age of 84 years (range 62 to 103), with 42% being female. The AI demonstrated high accuracy (0.93), sensitivity (0.86), and specificity (0.99) in detecting moderate to severe VFs. Subgroup analysis revealed accuracy ranging from 0.88 to 0.96, with higher accuracy in females compared to males (0.96 vs. 0.89, <i>p</i> = 0.03) and in scans performed with non-bone kernel versus bone kernel protocols (0.96 vs. 0.88, <i>p</i> = 0.02). No significant differences were found for age, contrast phase, or spinal region.</p><h3>Conclusion</h3><p>The results indicate that the AI algorithm exhibits high performance in a geriatric setting. If effectively integrated with a fracture liaison service, this could enhance VF detection considerable in the future.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11657-025-01524-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143688524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between dietary protein intake and bone mineral density in adolescents: a cross-sectional study","authors":"Chunhong Guo,&nbsp;Keyi Li,&nbsp;Mingxuan Zheng,&nbsp;Xiaojun Chen,&nbsp;Yishan Yin,&nbsp;Shaohua Chen","doi":"10.1007/s11657-025-01526-3","DOIUrl":"10.1007/s11657-025-01526-3","url":null,"abstract":"<div><h3>Summary</h3><p>Elevated daily protein consumption was significantly correlated with enhanced bone mineral density (BMD) across multiple skeletal sites in adolescents, as observed in the National Health and Nutrition Examination Survey. These results highlight the pivotal role of dietary protein in fostering bone health in the youth.</p><h3>Background</h3><p>The relationship between dietary protein intake and bone mineral density (BMD) remains inconclusive, particularly among adolescents. This study aimed to investigate the association between dietary protein intake and BMD in adolescents.</p><h3>Methods</h3><p>This cross-sectional study utilized data from 12–19-year-old participants in the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2010. Average daily protein intake was calculated from two consecutive 24-h dietary recalls. Dual-energy X-ray absorptiometry (DXA) was used to evaluate the BMD of the total femur, femoral neck, total spine, and lumbar spine. Multivariate linear regression was used to evaluate the association between dietary protein intake and BMD, adjusted for dietary protein intake per 10 g/day and multiple covariates. Stratified analysis, interaction analysis, and sensitivity analysis were performed to assess the consistency of this relationship and identify potential modifiers.</p><h3>Results</h3><p>After excluding missing data, the analysis included 2,640 adolescents. In the fully adjusted model, dietary protein intake showed a significant positive association with both total femur BMD (per 10 g/d: <i>β</i> = 5.25, 95% Cl = 1.69 ~ 8.82) and femoral neck BMD(per 10 g/d: <i>β</i> = 5.23, 95% Cl = 1.56 ~ 8.89). This positive association between dietary protein intake and BMD persisted in sensitivity analyses after multiple interpolation with all covariates missing. Subgroup analyses found no interaction between subgroups, or interaction results showed no clinical significance.</p><h3>Conclusion</h3><p>This study suggests that higher dietary protein intake is associated with increased BMD in US adolescents, highlighting the potential role of protein in adolescent bone health.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone stiffness and strength at the distal radius can be determined using photon-counting CT","authors":"Jilmen Quintiens,&nbsp;Elena Paravisi,&nbsp;Piyush Uniyal,&nbsp;G. Harry van Lenthe","doi":"10.1007/s11657-025-01527-2","DOIUrl":"10.1007/s11657-025-01527-2","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>Estimating bone strength aids in osteoporotic fracture risk assessment. Bone strength is usually calculated with a high-resolution CT; however, this modality has limited clinical utility. We demonstrated that clinical photon-counting CT can also be used for bone strength quantification, which facilitates the use of this information in clinical decision-making.</p><h3>Purpose</h3><p>Quantification of bone strength and microarchitecture at the distal radius with high-resolution peripheral quantitative computed tomography (HR-pQCT) can predict osteoporotic fracture risk independently of dual-energy X-ray absorptiometry. Photon-counting CT (PCCT) is a novel imaging technique with larger fields of view, shorter acquisition times, and similar resolution when compared to HR-pQCT. This study aimed to compare the stiffness and strength of the distal radius computed from PCCT and HR-pQCT images.</p><h3>Methods</h3><p>We evaluated a 10.2 mm section of the distal radius from eight cadaveric forearms scanned with PCCT and HR-pQCT at 0.11 mm and 0.061 mm voxel size, respectively. All CT images were converted to voxel-based linear finite element models. Two material models were used: a segmentation-based model with a fixed Young’s modulus of 10 GPa for bone elements, and a density-based model where Young’s modulus was assigned on a voxel-by-voxel basis, based on its gray value. Poisson’s ratio was set to 0.3 for all elements. Axial compression at 1% apparent strain was applied to quantify stiffness; strength was quantified with the Pistoia criterion. In addition, load sharing between cortical and trabecular bone was quantified.</p><h3>Results</h3><p>We found strong correlations between PCCT and HR-pQCT-derived bone stiffness, strength, and cortical and trabecular proportion for segmentation-based models (<i>R</i>² &gt; 0.911; <i>p</i> &lt; 2e-4). Correlation and agreement were higher for density-based models (<i>R</i>² &gt; 0.977; <i>p</i> &lt; 4e-6).</p><h3>Conclusion</h3><p>We demonstrated that PCCT can estimate bone strength with high accuracy and agreement when compared to HR-pQCT. These findings highlight PCCT’s potential in assessing fracture risk in osteoporosis. At the same time, PCCT’s large field of view enables broader usage, at sites different from peripheral limbs.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143667908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between dietary carotenoid intake and vertebral fracture in people aged 50 years and older: a study based on the National Health and Nutrition Examination Survey","authors":"Yuchen Zheng,&nbsp;Wenyu Zhou,&nbsp;Jian Zhang,&nbsp;Tao Lan,&nbsp;Rui Zhang","doi":"10.1007/s11657-025-01508-5","DOIUrl":"10.1007/s11657-025-01508-5","url":null,"abstract":"<div><h3>Summary</h3><p>This study discussed the association between dietary intake of carotenoids and vertebral fractures by analyzing the target data, concluding a result of negative association and providing valuable information on vertebral fracture.</p><h3>Objective</h3><p>This study is to explore the association between dietary intake of carotenoids and vertebral fractures.</p><h3>Methods</h3><p>Data of individuals aged ≥ 50 years from the 2013–2014 National Health and Nutrition Examination Survey (NHANES) database were used in this cross-sectional study. Information on dietary carotenoid intake was obtained from the first 24-h dietary recall interview. Vertebral fractures were assessed using dual-energy x-ray absorptiometry (DXA). The weighted multivariable logistic regression model was established to assess the association between dietary carotenoid intake and risk of vertebral fracture. Subgroup analysis of fracture history and menopausal status was performed for further analysis of this relationship.</p><h3>Results</h3><p>Of the 2053 eligible study subjects, there were 1021 men and 1032 women. Increased β-carotene intake was associated with decreased odds of vertebral fracture in women (odds ratio (OR) = 0.77, 95% confidence interval (CI) 0.60–0.99, <i>P</i> = 0.047), after adjusting for covariates. In men without a history of fracture, lutein and zeaxanthin intake was negatively associated with increased odds of vertebral fracture (OR = 0.70, 95% CI 0.50–0.99, <i>P</i> = 0.048). In women without a history of fracture, increased β-carotene intake was associated with decreased odds of vertebral fracture (OR = 0.78, 95% CI 0.61–0.99, <i>P</i> = 0.047). In postmenopausal women, β-carotene intake was also negatively associated with increased odds of vertebral fracture (OR = 0.77, 95% CI 0.60–0.99, <i>P</i> = 0.048).</p><h3>Conclusion</h3><p>This research concludes a negative association between dietary carotenoid intake, especially β-carotene, and vertebral fractures in women, revealing a potential dietary prevention tactic for vertebral fractures in the future.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11657-025-01508-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}