Archives of Osteoporosis最新文献

{"title":"Author Correction: Exploring the shared genetic architecture of type 2 diabetes mellitus and bone mineral density.","authors":"Xinran Feng, Hongbin Xu, Qian Guo, Zeying Wang, Ruikai Ba, Kun Xuan, Jinghao Ban","doi":"10.1007/s11657-025-01581-w","DOIUrl":"https://doi.org/10.1007/s11657-025-01581-w","url":null,"abstract":"","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":"94"},"PeriodicalIF":3.1,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Correction: Acquired hypophosphatemic osteomalacia: case series from a Peruvian referral center (1999-2023).","authors":"José Paz-Ibarra, Sofía Sáenz-Bustamante, Manuel Inostroza-Fernández, Paola Sifuentes Hermenegildo, Liliana Ancajima Lescano, Marcio Concepción-Zavaleta, Alejandro Román-González, Alfredo Adolfo Reza-Albarrán","doi":"10.1007/s11657-025-01583-8","DOIUrl":"https://doi.org/10.1007/s11657-025-01583-8","url":null,"abstract":"","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":"92"},"PeriodicalIF":3.1,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative outcomes of denosumab and zoledronic acid discontinuation in hip fracture surgery: a nationwide database study.","authors":"Seok Ha Hong, Yeon Ju Yu, Seung Beom Han","doi":"10.1007/s11657-025-01560-1","DOIUrl":"https://doi.org/10.1007/s11657-025-01560-1","url":null,"abstract":"<p><p>In hip fracture patients with poor medication adherence, DMAB discontinuation significantly increased the risk of subsequent vertebral and rib fractures. Additionally, higher CCI scores were associated with an increased risk of these fractures. These findings underscore the importance of maintaining treatment adherence to minimize fracture risk in this vulnerable population.</p><p><strong>Purpose: </strong>To assess the risk of major osteoporotic fractures and periprosthetic fractures in hip fracture patients who discontinued denosumab (DMAB) or zoledronic acid (ZOL).</p><p><strong>Methods: </strong>Data from the South Korean National Health Insurance Review and Assessment Service were analyzed, focusing on patients aged ≥ 60 years who underwent hip fracture surgery and initiated DMAB or ZOL treatment. Among 20,180 patients, 1737 discontinued DMAB, and 3720 discontinued ZOL. After 1:1 propensity score matching, 3240 patients were included in the final analysis. The DMAB group was stratified into three subgroups based on the cumulative DMAB duration after hip fracture surgery: 1-2, 2-3, and > 3 Y. Discontinuation was defined as a 270-day gap for DMAB or 540-day gap for ZOL last injections. Subsequent osteoporotic fractures after discontinuation were evaluated.</p><p><strong>Results: </strong>DMAB discontinuation significantly increased the risk of subsequent vertebral fractures (hazard ratio [HR] = 1.81; 95% confidence interval [CI], 1.28-2.56, P = 0.01) and rib fractures (HR = 2.04; 95% CI, 1.27-3.23, P = 0.004) compared to ZOL discontinuation. Higher Charlson Comorbidity Index (CCI) scores were also significantly associated with an increased risk of subsequent vertebral (HR 1.05, 95% CI 1.03-1.09, P = 0.02) and rib fractures (HR 1.12, 95% CI 1.06-1.19, P < 0.01). Although the incidence of hip fractures was lower in DMAB discontinuation group (1 case) than in the ZOL discontinuation group (10 cases), this difference did not reach statistical significance. No significant difference was observed in the risk of other nonvertebral fractures (humerus, wrist, ankle) and periprosthetic fracture between the two groups.</p><p><strong>Conclusion: </strong>This nationwide study, the first to use real-world data, highlighted the significant increase in the risk of vertebral and rib fracture associated with DMAB discontinuation in patients with poor adherence and higher comorbidity burden. Optimizing medication adherence is crucial to minimize the fracture risk in this vulnerable population.</p><p><strong>Level of evidence: </strong>Level III, Prognostic.</p>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":"93"},"PeriodicalIF":3.1,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144635981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between ramelteon use and risk of fragility fractures: A retrospective cohort study.","authors":"Hitoshi Tange, Yoshihisa Miyamoto, Yusuke Sasabuchi, Hideo Yasunaga","doi":"10.1007/s11657-025-01582-9","DOIUrl":"https://doi.org/10.1007/s11657-025-01582-9","url":null,"abstract":"<p><p>The effect of melatonin receptor agonists on bone remains unclear. This retrospective cohort study provides the first evidence that the short- to mid-term use of ramelteon is not associated with the risk of fracture. Further research with longer follow-up is needed to clarify the effects of ramelteon on bone health.</p><p><strong>Background: </strong>Recent studies have suggested that melatonin may have the potential to treat osteoporosis. However, few studies have examined the effects of melatonin receptor agonists on bone health. This study aimed to evaluate the association between ramelteon use and the risk of fragility fractures.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study from April 2014 to November 2022 using the DeSC database, a large healthcare claims database in Japan, employing an active comparator and new-user design. Female participants aged ≥ 50 years were included in the study. Exposure was defined as the first dispensation of ramelteon or orexin receptor antagonists. The outcome was a composite of major fragility fractures, including hip, vertebral, wrist, proximal humeral, and ankle fractures. To adjust for potential confounders, we used overlap weighting analysis with propensity scores. Cox regression analyses were performed both before and after applying overlap weighting.</p><p><strong>Results: </strong>A total of 106,511 individuals were identified, including 23,312 new ramelteon users and 83,199 new orexin receptor antagonist users. The overall fracture incidence was 9,429 per 100,000 person-years in the ramelteon group and 7,330 per 100,000 person-years in the orexin receptor antagonist group. The adjusted hazard ratio for overall fractures associated with ramelteon use was 1.07 (95% confidence interval: 0.99-1.17). The results were consistent across fracture types, age groups, and landmark analyses.</p><p><strong>Conclusions: </strong>In a real-world setting, short- to mid-term ramelteon use was not associated with an increased risk of fractures. Future studies should consider longer follow-up periods to further investigate the effects of ramelteon on bone health.</p>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":"95"},"PeriodicalIF":3.1,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of gestational age and intrauterine growth on bone mass in adolescents: findings from a Brazilian Birth Cohort Study.","authors":"Isabel Oliveira Bierhals, Luciana Tovo-Rodrigues, Alicia Matijasevich, Iná S Santos","doi":"10.1007/s11657-025-01574-9","DOIUrl":"https://doi.org/10.1007/s11657-025-01574-9","url":null,"abstract":"<p><p>Osteoporosis in adulthood often originates in early life, and some forms can be prevented through appropriate attention to bone health during the neonatal period and childhood, particularly in cases involving preterm infants or with intrauterine growth restriction.</p><p><strong>Purpose: </strong>To test the association of gestational age and intrauterine growth with bone mass in adolescents.</p><p><strong>Methods: </strong>With data from the 2004 Pelotas Birth Cohort, the outcomes density (aBMD) and content (BMC) were obtained by dual-energy X-ray absorptiometry, measured at 15 years. The exposures of interest were: prematurity (< 37 weeks of gestation), gestational age (≤ 36, 37-41, and ≥ 42 weeks) and intrauterine growth (small - SGA, appropriate - AGA or large for gestational age - LGA). Linear regression stratified by sex was run. Exclusive breastfeeding at 3 months was tested as an effect modifier.</p><p><strong>Results: </strong>One thousand four hundred ninety-four participants were included. In full adjusted model, including adolescent's height, preterm females had lower aBMD femoral neck than the full-term (β - 0.04 g/cm²; 95% CI - 0.07; - 0.01; p = 0.012) and those born with ≥ 42 weeks of gestation (β - 0.07 g/cm²; 95% CI - 0.13; - 0.01; p = 0.026). Males born with ≤ 36 and 37-41 weeks of gestation presented less BMC femoral neck than those born with ≥ 42 weeks (β - 0.8 g; 95% CI - 1.4; - 0.2 and β - 0.8 g; 95% CI - 1.4; - 0.2, respectively). LGA females presented approximately 100 g more in the whole-body BMC (β 97.3 g; 95% CI 20.5; 174.1; p = 0.022) than AGA females. SGA females who received exclusive breastfeeding at 3 months presented higher BMD (lumbar spine and femoral neck) and BMC than those who did not receive exclusive breastfeeding.</p><p><strong>Conclusion: </strong>Even the adolescence phase can be impaired due to premature birth and intrauterine growth restriction.</p>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":"89"},"PeriodicalIF":3.1,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144616063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opportunistic assessment of bone mineral density in cystic fibrosis patients using ultra-low dose thoracic CT.","authors":"Sahil Shet, Catherine Henry, Mairead O'Donnell, Eid Kakish, Muhammad Ghauri, Patrick O'Regan, Kevin Deasy, Hisham Ibrahim, Michael Maher, Barry Plant, David J Ryan","doi":"10.1007/s11657-025-01578-5","DOIUrl":"10.1007/s11657-025-01578-5","url":null,"abstract":"<p><p>In this study, we used routine ultra-low dose computed tomography scans of patients with cystic fibrosis to predict bone mineral density (BMD). A strong correlation was found between the attenuation of trabecular bone in thoracic vertebrae and the BMD in the proximal femur and lumbar spine as measured on DEXA.</p><p><strong>Purpose: </strong>Osteoporosis is a serious global health concern with millions of people affected worldwide. A particularly vulnerable cohort in developing osteoporosis are patients with cystic fibrosis (CF). Bone mineral density (BMD) is typically measured with dual energy X-ray absorptiometry (DEXA) scanning; however, this comes at a cost to the healthcare system and an exposure to ionising radiation. In our institution, patients with cystic fibrosis undergo routine ultra-low dose computed tomography (ULDCT) for monitoring of disease progression. The aim of this study was to assess the validity of estimating BMD using data derived from ULDCT scans.</p><p><strong>Methods: </strong>Adult CF patients were included if they had undergone a routine ULDCT scan within 12 months of a DEXA scan. Additionally, 100 non-CF patients with non-contrast standard dose CT scans were selected to act as the control group. Trabecular bone density (T-BD) at T4, T7 and T10 was measured on PACS in Hounsfield units (HU) and compared to DEXA scan results and a formula developed to the predict BMD.</p><p><strong>Results: </strong>Fifty-two female and 62 male patients were included with mean ages of 34.4 and 35.1 respectively. Moderately strong correlation was found between the T-BD and BMD of both the lumbar spine (r = 0.629, p < 0.001) and proximal femur (r = 0.649, p < 0.001). Receiver operator characteristic (ROC) curve analysis found a sensitivity and specificity of 0.700 and 0.714 respectively at predicting osteoporosis at T-BD of 193.33 HU or below.</p><p><strong>Conclusion: </strong>T-BD measured on ULDCT may be a valuable tool in the early identification of CF patients at risk of osteoporosis.</p>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":"91"},"PeriodicalIF":3.1,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12255546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144616061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of fragility fracture of pelvis in endometrial cancer survivors : A national claim database study.","authors":"Ki-Tae Park, Jung-Wee Park, Dong-Hoon Lee, Ye Jhin Jeon, Jean Kyung Bak, Bit-Na Yoo, Youn Kyung Chung, Byung-Ho Yoon, Young-Kyun Lee","doi":"10.1007/s11657-025-01577-6","DOIUrl":"https://doi.org/10.1007/s11657-025-01577-6","url":null,"abstract":"<p><p>This study investigates the incidence and risk factors of pelvic fragility fractures in endometrial cancer survivors using a national claims database. The incidence was 0.6%, with older age as a significant risk factor. These findings emphasize the need for careful detection and management to improve outcomes.</p><p><strong>Purpose: </strong>This study aimed to evaluate the incidence of fragility fracture of pelvis (FFP) in endometrial cancer survivors and identify associated risk factors using data from the Korean National Claims Database.</p><p><strong>Methods: </strong>A total of 6923 endometrial cancer patients were identified between 2007 and 2016 using data from the linkage between the Korea National Health Insurance Service and Korea Central Cancer Registry. The incidence of FFP was estimated and risk factors, such as age, radiation therapy (RT) status, medical institution type, residential area, income level, insurance type, and comorbidities, were assessed using a Cox proportional hazards regression.</p><p><strong>Results: </strong>The overall incidence of FFP was 0.6%, with a higher incidence in patients who underwent RT (0.8%) compared to those who did not (0.5%). However, the difference was not statistically significant (P = 0.355). Older age was significantly associated with an increased risk of FFPs (adjusted HR = 1.101, 95% CI 1.066-1.138; P < 0.001).</p><p><strong>Conclusions: </strong>The incidence of FFP in endometrial cancer survivors was 0.6%, with a slightly higher rate in those who received RT. Older age was a significant risk factor of FFP. These findings emphasize the need for careful detection and management of FFP, particularly in older patients, to improve long-term outcomes in endometrial cancer survivors.</p>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":"90"},"PeriodicalIF":3.1,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144616062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical insights into the role of smoking, diabetes, and rheumatoid arthritis in osteoporotic fractures.","authors":"Md Saddam Hussain, Tarequl Islam, Md Safiqul Islam, Danishuddin, Md Azizul Haque","doi":"10.1007/s11657-025-01575-8","DOIUrl":"https://doi.org/10.1007/s11657-025-01575-8","url":null,"abstract":"<p><strong>Background: </strong>Osteoporotic fractures pose a significant public health challenge, with various risk factors contributing to their incidence. Smoking, diabetes mellitus (DM), and rheumatoid arthritis (RA) are known to disrupt bone metabolism and increase fracture susceptibility. Moreover, smoking is a well-known risk factor of DM and RA, and thereby imposes a greater impact on osteoporotic fractures. This review explores the impact of these conditions on osteoporotic fractures, emphasizing the underlying mechanisms and clinical implications.</p><p><strong>Methods: </strong>A comprehensive literature review was conducted to examine the biochemical and physiological effects of smoking, DM, and RA on bone metabolism. The review focused on key regulatory pathways, including the role of parathyroid hormone (PTH), vitamin D, receptor activator of nuclear factor kappa-B ligand (RANKL), osteoprotegerin (OPG), and inflammatory cytokines.</p><p><strong>Results: </strong>Smoking contributes to osteoporotic fractures by altering bone metabolism through multiple mechanisms, including dysregulation of PTH, vitamin D, and the RANKL/OPG balance. RA disrupts bone homeostasis by increasing osteoclast activity, reducing osteoblast function, and elevating pro-inflammatory cytokines such as IL-1, IL-6, and TNF-α. Additionally, RA treatment with glucocorticoids further impairs calcium balance and bone integrity. DM accelerates bone resorption by upregulating osteoclastogenic factors (e.g., TNF-α, VEGF, RANKL) and suppressing osteoblastogenic pathways (e.g., Runx2). It also reduces essential bone-forming substances, including PTH and osteocalcin, while promoting the accumulation of advanced glycation end-products and adiposity, both of which negatively impact bone health.</p><p><strong>Conclusions: </strong>Smoking, DM, and RA significantly contribute to osteoporotic fractures by disrupting bone metabolism through direct biochemical alterations and treatment-related effects. Furthermore, smoking exacerbates both DM and RA, compounding the risk of fractures. Effective clinical management of these risk factors is essential to reducing the burden of osteoporotic fractures and improving patient outcomes.</p>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":"87"},"PeriodicalIF":3.1,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144607252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comorbidity burden, management, and in-hospital outcomes in centenarians with proximal hip fracture: a nationwide cohort study (2004-2020).","authors":"Juan Carlos Piñeiro-Fernández, Ramón Rabuñal-Rey, Eva Romay-Lema, David Rubal-Bran, Cristina Pedrosa-Fraga, Ana María Santos-Martínez, Yoana Besteiro-Balado, Roi Suárez-Gil, Sonia Pértega-Díaz","doi":"10.1007/s11657-025-01576-7","DOIUrl":"10.1007/s11657-025-01576-7","url":null,"abstract":"<p><p>This study analyses comorbidity, surgical management, and complications and their impact on in-hospital outcomes in centenarian hip fracture patients admitted in Spain, 2004-2020. It provides evidence on the prognostic impact of comorbidity and in-hospital complications and highlights the need for specific interventions to improve care in this vulnerable population.</p><p><strong>Purpose: </strong>This work aims to describe the clinical characteristics, in-hospital progress, and risk factors for worse in-hospital outcomes in centenarian patients with proximal hip fracture (PHF).</p><p><strong>Methods: </strong>A retrospective nationwide cohort study was conducted that included all centenarian patients hospitalized for PHF (2004-2020) according to the Spanish National Health System's Minimum Basic Data Set. Demographic, clinical, and hospitalization-related variables were analyzed. Univariate and multivariate analyses were performed.</p><p><strong>Results: </strong>This study included 4261 patients (83.3% women). The mean Charlson comorbidity index (CCI) was 0.9 ± 1.2; 11.4% had severe comorbidity. Surgery was performed in 87.2% of patients and in 44.5% after 48 h of admission. Higher CCI scores (OR 1.3, 95% CI 1.0-1.7) and admission to medical departments (OR 4.11, 95% CI 3.0-5.6) were associated with nonsurgical management. Surgical delays ≥ 48 h were associated with admissions on Saturdays (OR 1.9, 95% CI 1.3-2.8) or to medical departments (OR 2.79, 95% CI 1.34-5.83) and with the development of ≥ 3 complications (OR 1.5, 95% CI 1.1-2.0). Overall, 15% of patients died during hospitalization, with significantly higher mortality in nonsurgical patients (31.8% vs. 12.5%, p < 0.001). In surgical patients, mortality and prolonged hospital stays were primarily related to higher CCI scores and complications.</p><p><strong>Conclusions: </strong>Centenarians with PHF have a low severe disease burden but high in-hospital mortality risk. Key predictors of mortality in surgical patients include higher CCI scores and in-hospital complications. This highlights the relevance of integrated care and early optimization of clinical status. Prospective studies with long-term follow-up are needed to better characterize prognostic factors.</p>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":"88"},"PeriodicalIF":3.1,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12254154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144616060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparisons of reference curves for femoral neck geometric parameters between Changsha-Chinese women and women of three ethnic groups in the United States.","authors":"Lin Li, Yi Shen, Hong Zhang, Ru-Chun Dai, Ling-Qing Yuan, Zhi-Feng Sheng, Xi-Yu Wu","doi":"10.1007/s11657-025-01571-y","DOIUrl":"10.1007/s11657-025-01571-y","url":null,"abstract":"<p><p>Factors underlying ethnic differences in the incidence of femoral fractures are not fully understood. Reference curves of femoral neck geometric parameters (FNGPS) between Changsha-Chinese women and three United States (US) ethnic groups of women varied by ethnicity, age, and measurement parameters. Further investigations might better explain fracture-rate differences.</p><p><strong>Purpose: </strong>Osteoporotic fractures are associated with race, and the risk of femoral neck fractures is associated with FNGPs. We compared age-related FNGPs of Changsha-Chinese women with those of three ethnic groups of women in the US.</p><p><strong>Methods: </strong>Data on 4236 Changsha-Chinese women and non-Hispanic Whites (NHWs), non-Hispanic Blacks (NHBs) and Mexican women (aged 20-91 years) from a laboratory database and research literature, were analyzed to measure their FNGPs: outer diameter (OD), cross-sectional area (CSA), averaged cortical thickness (ACT), endocortical diameter (ED), buckling ratio (BR), section modulus (SM), and cross-sectional moment of inertia (CSMI).</p><p><strong>Results: </strong>The overall means of the OD, ED, SM, and CSMI of the Changsha-Chinese women were significantly lower than those of the NHWs. Their CSA, ACT, SM, and CSMI were significantly lower than that of the NHBs and the age-related reference curves of their CSA, ACT, SM, and CSMI were significantly lower than those of the NHWs, NHBs, and Mexican women. Their OD and ED reference curves were significantly lower than those of the NHWs and NHBs; their OD, CSA, and ACT reference curves were lower than those of the NHWs; and their CSA, ACT, and SM were significantly lower than those of the NHBs. However, their buckling ratio (BR) reference curve was significantly higher than that of the NHWs, NHBs, and Mexican women in the US.</p><p><strong>Conclusion: </strong>Ethnic differences in the FNGPs of Changsha-Chinese women and US ethnic groups may explain differences in hip-fracture rates among different ethnic groups.</p>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":"86"},"PeriodicalIF":3.1,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12238157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}