Archives of Osteoporosis最新文献

{"title":"Effect of comorbidities and multimorbidity on bone mineral density in patients with osteoporosis","authors":"Luis Leal-Vega,&nbsp;María Begoña Coco-Martín,&nbsp;Adrián Martín-Gutiérrez,&nbsp;José Antonio Blázquez-Cabrera,&nbsp;Francisca Arranz-García,&nbsp;Amalia Navarro,&nbsp;María Jesús Moro,&nbsp;José Filgueira,&nbsp;Manuel Sosa-Henríquez,&nbsp;María Ángeles Vázquez,&nbsp;María José Montoya,&nbsp;Manuel Díaz-Curiel,&nbsp;José Manuel Olmos,&nbsp;José Luis Pérez-Castrillón,&nbsp;OSTEOMED Group","doi":"10.1007/s11657-025-01604-6","DOIUrl":"10.1007/s11657-025-01604-6","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>This retrospective cohort study analysed a total of 344 patients from the OSTEOMED registry with matched baseline and follow-up DXA data, finding that comorbidities such as nephrolithiasis, hypertension or coronary heart disease may influence the response to prescribed anti-osteoporotic treatment.</p><h3>Purpose</h3><p>To determine: 1) comorbidities associated with reduced bone mineral density (BMD), T-score and Z-score at the lumbar spine (L1 to L4 vertebrae), femoral neck and total hip; and 2) the role of multimorbidity (≥ 2 comorbidities) in reduced BMD, T-score and Z-score at the lumbar spine, femoral neck and total hip.</p><h3>Methods</h3><p>Retrospective cohort study analyzing patients [319 females (92.73%), 25 males (7.27%), age 62.13 ± 10.46 years] from the OSTEOMED registry with matched baseline and follow-up dual-energy X-ray absorptiometry (DXA) data. Patients' sex, age, body mass index (BMI), comorbidities and treatments were collected from their medical records after they had given written informed consent.</p><h3>Results</h3><p>Considering a least significant change (LSC) of 4.2%, neither comorbidity nor multimorbidity was statistically significantly associated with a reduction in BMD in any of the bone regions studied. However, binary logistic regression analyses adjusted for sex, age, BMI and treatments showed that nephrolithiasis (<i>p</i> = 0.044) and coronary heart disease (<i>p</i> = 0.026) were statistically significantly associated with a reduction in total hip T-score and that hypertension (<i>p</i> = 0.049) and coronary heart disease (<i>p</i> = 0.01) were statistically significantly associated with a reduction in total hip Z-score.</p><h3>Conclusion</h3><p>Despite comorbidity and multimorbidity, patients with osteoporosis are mostly well protected by anti-osteoporotic treatment in daily clinical practice. However, nephrolithiasis, hypertension, and coronary heart disease can influence the response to prescribed anti-osteoporotic treatment, especially at the total hip level.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11657-025-01604-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145011723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The associations of multimorbidity with fall- and fracture-related hospitalisations: the Busselton Healthy Ageing Study","authors":"Mark A Hoey,&nbsp;Kun Zhu,&nbsp;Kevin Murray,&nbsp;Chrianna Bharat,&nbsp;Robert H Eikelboom,&nbsp;Michael Hunter","doi":"10.1007/s11657-025-01600-w","DOIUrl":"10.1007/s11657-025-01600-w","url":null,"abstract":"<div><h3>Summary</h3><p>In middle-aged adults, we evaluated the associations between multimorbidity count and patterns with fall- and fracture-related hospitalisations. Falls risk increased linearly with multimorbidity count, and certain multimorbidity patterns were associated with increased risks of falls and fractures. Multimorbidity count and pattern should therefore be considered when risk stratifying patients.</p><h3>Purpose</h3><p>Although multimorbidity is recognised as a risk factor for falls and fractures, most studies are retrospective, and few have explored these relationships through statistically derived multimorbidity patterns. Our prospective cohort study with 4991 participants of the Busselton Healthy Ageing Study aged 45–69 years evaluated the associations of multimorbidity count and classes with incident fall- and fracture-related hospitalisations.</p><h3>Methods</h3><p>Twenty-one morbidities were assessed at baseline, and four multimorbidity classes were identified using latent class analysis. Fall- and fracture-related hospitalisations were captured through the Western Australian Data Linkage System over a median follow-up of 7.9 years. Associations were examined using Cox regression models adjusting for sex, baseline age, lifestyle factors, and prior falls/fractures.</p><h3>Results</h3><p>During follow-up, incident fall- and fracture-related hospitalisations were recorded for 177 (3.5%) and 197 (3.9%) participants, respectively. Each one-unit increase in multimorbidity count was associated with a 16% (95% CI, 7.8–25%) increased risk of fall-related hospitalisations. Multimorbidity scores of 9 and above (HR 2.32 [1.22–4.42]) showed an increased risk of fractures. Compared with the relatively healthy class, the cardiometabolic or mental health and musculoskeletal classes were associated with an increased risk of fall-related hospitalisations (HR 2.84 [1.76–4.59] and 1.78 [1.23–2.59], respectively). The cardiometabolic class was associated with an increased risk of fracture-related hospitalisations (HR 1.79 [1.04–3.07]).</p><h3>Conclusion</h3><p>In middle-aged adults, we showed that multimorbidity count and certain multimorbidity patterns were associated with increased risk for fall- and fracture-related hospitalisations. Multimorbidity should therefore be considered when assessing a patient’s risk of falls and fractures.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11657-025-01600-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in the prevalence of hypovitaminosis D over a 10-year period in Japan: the research on osteoarthritis/osteoporosis against disability study 2005–2015","authors":"Noriko Yoshimura,&nbsp;Toshiko Iidaka,&nbsp;Chiaki Horii,&nbsp;Gaku Tanegashima,&nbsp;Shigeyuki Muraki,&nbsp;Hiroyuki Oka,&nbsp;Hiroshi Kawaguchi,&nbsp;Toru Akune,&nbsp;Kozo Nakamura,&nbsp;Sakae Tanaka","doi":"10.1007/s11657-025-01601-9","DOIUrl":"10.1007/s11657-025-01601-9","url":null,"abstract":"<div><h3>Summary</h3><p>We examined the trends in vitamin D insufficiency and deficiency over a 10-year period in the general population. The prevalence of deficiency significantly decreased (29.5% vs. 21.6%), whereas mean serum levels increased (23.3 ng/mL vs. 25.1 ng/mL). These trends may reduce the incidence of osteoporosis and osteoporotic fractures.</p><h3>Purpose</h3><p>We aimed to clarify the trends in the prevalence of vitamin D insufficiency and deficiency in the general population using population-based cohort data from a baseline survey and a follow-up survey conducted 10 years later.</p><h3>Methods</h3><p>A baseline survey of the Research on Osteoarthritis/Osteoporosis Against Disability (ROAD) study was conducted from 2005 to 2007. Blood samples were collected to measure serum 25-hydroxyvitamin D (25D) and intact parathyroid hormone levels from 1,683 participants (595 men, 1,088 women). Participants also completed an interviewer-administered questionnaire, and underwent bone mineral density measurements and radiographic examinations. The fourth survey was conducted from 2015 to 2016 with 1,906 individuals (637 men, 1,269 women), including both follow-up participants from the baseline survey and newly recruited individuals to increase the sample size for future longitudinal analyses. All participants completed assessments identical to those in the baseline survey. Vitamin D deficiency and insufficiency were defined as serum 25D levels of &lt; 20 ng/mL and ≥ 20 ng/mL but &lt; 30 ng/mL, respectively.</p><h3>Results</h3><p>The mean serum vitamin D levels were 23.3 ng/mL at baseline and 25.1 ng/mL at the fourth survey, indicating a significant increase (<i>p</i> &lt; 0.001). The prevalences of vitamin D insufficiency and deficiency were 52.9% and 29.5%, respectively, at baseline, and 54.8% and 21.6%, respectively, in the fourth survey, indicating a significant decrease in vitamin D deficiency (<i>p</i> &lt; 0.001).</p><h3>Conclusions</h3><p>In this population-based survey with a 10-year interval, the prevalence of hypovitaminosis D significantly decreased. This favourable trend may contribute to future reductions in the incidence of osteoporosis and osteoporotic fractures.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11657-025-01601-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144909622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of plasma levels of protein-bound advanced glycation end-products and their soluble receptors with bone mineral status in young girls with the restrictive type of anorexia nervosa","authors":"Katarína Šebeková,&nbsp;Alexandra Gaál Kovalčíková,&nbsp;Alžbeta Čagalová,&nbsp;Ľubica Tichá,&nbsp;Ľudmila Podracká","doi":"10.1007/s11657-025-01554-z","DOIUrl":"10.1007/s11657-025-01554-z","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>In diabetes- and age-related osteopenia/osteoporosis, a pathogenetic role of advanced glycation end-products and their soluble receptors (RAGE) is implicated. We studied how these compounds relate to bone health in girls with anorexia nervosa. We found that higher levels of endogenous secretory RAGE were associated with poorer bone quality, warranting further research.</p><h3>Purpose</h3><p>We explored the association of plasma protein–bound advanced glycation end-products (AGEs) and their soluble receptors with bone mineralization and turnover markers in girls with a restrictive type of anorexia nervosa.</p><h3>Methods</h3><p>A total of 102 girls with anorexia nervosa aged 14.0 ± 2.7 years and 29 age-matched healthy controls were included. Plasma levels of chemically defined AGEs (N^ε-(carboxymethyl)-lysine, methylglyoxal-derived hydroimidazolone-1, and their soluble receptors were determined using the ELISA methods; parathormone, osteocalcin, amino-terminal propeptide of human procollagen type I, carboxy-terminal telopeptide of type I collagen (CTX), and estradiol using the electrochemiluminescence. Girls with AN underwent dual-energy X-ray absorptiometry to assess bone mineral density (BMD) and trabecular bone score (TBS). Multivariate regression was performed using the orthogonal projection to latent structures model.</p><h3>Results</h3><p>Girls with anorexia nervosa displayed higher plasma levels of N^ε-(carboxymethyl)-lysine (by 52%) and methylglyoxal-derived hydroimidazolone-1 (by 34%) than controls, while soluble RAGE levels were similar in both groups. In girls with anorexia nervosa, low levels of nutritional markers, high endogenous secretory RAGE, and high CTX predicted low hip and femoral neck BMD. Low levels of nutritional markers and high bone turnover markers predicted TBS.</p><h3>Conclusions</h3><p>To clarify the role of the AGEs/RAGE axis in anorexia nervosa-associated low bone mass, longitudinal studies assessing the dynamic changes of these markers during re-alimentation-induced weight restoration and bone health recovery are needed. In clinical practice, monitoring of the AGEs/sRAGE axis could offer a novel approach for assessing disease status and guiding personalized interventions to mitigate long-term health consequences in patients with AN.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11657-025-01554-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144909648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of information in osteoporosis videos on TikTok: a cross-sectional study","authors":"Huipin Zhang,&nbsp;Chaomei Zhang,&nbsp;Jing Mo,&nbsp;Wenyan Wang,&nbsp;Zhishui Wu","doi":"10.1007/s11657-025-01597-2","DOIUrl":"10.1007/s11657-025-01597-2","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>This study evaluated the quality of osteoporosis videos on TikTok, finding that while most are by doctors, the information quality is low. Longer videos tend to have better quality but receive less engagement, highlighting concerns about the suitability of TikTok for medical education.</p><h3>Background</h3><p>TikTok has become a significant channel for the general public to access and adopt health information. However, the quality of health content about osteoporosis on TikTok remains underexplored.</p><h3>Objective</h3><p>This study aimed to investigate the information quality of osteoporosis videos on TikTok.</p><h3>Methods</h3><p>We analyzed the first 200 videos related to osteoporosis on TikTok, focusing on 128 videos that met our criteria. The quality of these videos was evaluated using quantitative scoring tools such as the DISCERN instrument and Content Integrity Assessment. Additionally, the correlation between video quality and characteristics, including duration, likes, comments, and shares, was investigated.</p><h3>Results</h3><p>Of the videos analyzed, 93.0% were posted by doctors. Content integrity scores were as follows: definition 0.61 ± 0.77, symptoms 0.34 ± 0.71, evaluation 0.39 ± 0.71, risk factors 0.55 ± 0.65, management 0.82 ± 0.56, and outcomes 1.17 ± 0.75. The average DISCERN score was 36.51 ± 6.87, the majority of videos were rated as poor (71.1%) or fair (22.7%) in quality. DISCERN scores of videos published by doctors were lower than those created by non-professionals (<i>Z = -</i>2.062, <i>P </i>= 0.039). DISCERN scores were significantly correlated with video duration (<i>r</i> = 0.581, <i>P</i> &lt; 0.001). Engagement metrics such as likes, comments, favorites, and shares were highly interrelated (<i>r</i> = 0.855 to 0.901, <i>P </i>&lt; 0.001), but did not correlate with video quality (<i>P </i>&gt; 0.05).</p><h3>Conclusion</h3><p>Although the videos about osteoporosis on TikTok are mainly provided by doctors, their quality is low. We found a positive correlation between video duration and video quality. High-quality videos received low attention, while popular videos were of low quality. The medical information on TikTok is currently not rigorous enough to guide patients to make accurate judgments. Due to the low quality and reliability of the information, TikTok is not an appropriate source of knowledge to educate patients.\u0000</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144843181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent pathological fractures in chronic kidney disease revealing overlapping neglected primary hyperparathyroidism and GDF5-associated skeletal dysplasia","authors":"Po-Kai Chan,&nbsp;Chun-Liang Hsu,&nbsp;Si-Yuan Wu,&nbsp;Yu-Juei Hsu,&nbsp;Shun-Neng Hsu","doi":"10.1007/s11657-025-01592-7","DOIUrl":"10.1007/s11657-025-01592-7","url":null,"abstract":"<div><h3>Introduction</h3><p>Primary hyperparathyroidism (PHPT) is a common endocrine disorder characterized by the excessive secretion of parathyroid hormone (PTH), resulting in significant hypercalcemia and skeletal complications. In the context of chronic kidney disease (CKD), neglected PHPT can progress to a biochemical profile resembling tertiary hyperparathyroidism (THPT), further complicating diagnosis, especially when concomitant genetic skeletal disorders (GSD) exist. </p><h3>Case report</h3><p>We present a rare and complex case of a 63-year-old woman with stage 3 CKD who presented with recurrent pathological fractures, severe hypercalcemia, and extensive osteolytic bone lesions in both femurs. The patient’s clinical picture was complicated by notable skeletal anomalies, including short stature, brachydactyly, and hypoplastic metatarsals. Elevated serum calcium, markedly increased PTH levels, hypercalciuria, hyperphosphaturia, and parathyroid imaging, confirmed previously untreated PHPT resulting in a THPT-like biochemical profile in the setting of CKD. The patient ultimately underwent surgical fixation for bilateral lower limb fractures, followed by a simple parathyroidectomy, achieving symptomatic relief and metabolic stabilization. A genetic investigation, prompted by distinctive skeletal features, uncovered a frameshift mutation in the growth differentiation factor 5 (GDF5) gene indicative of brachydactyly type C, a rare form of GSD.</p><h3>Conclusion</h3><p>This case highlights the complexity in differentiating PHPT from other causes of hyperparathyroidism in the setting of CKD, particularly when concurrent skeletal dysplasia is present. The thorough clinical, biochemical, imaging, and genetic assessments were pivotal in reaching an accurate diagnosis and guiding appropriate surgical management.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144811657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of subclinical manifestations of coronary and carotid artery atherosclerosis with bone strength parameters in asymptomatic women","authors":"Irina A. Skripnikova,&nbsp;Maria A. Kolchina,&nbsp;Olga V. Kosmatova,&nbsp;Olesia Yu. Isaykina,&nbsp;Vladimir A. Vygodin,&nbsp;Oxana M. Drapkina","doi":"10.1007/s11657-025-01537-0","DOIUrl":"10.1007/s11657-025-01537-0","url":null,"abstract":"<div><h3>Summary</h3><p>We studied the associations between the state of the vascular wall in the coronary and carotid arteries with bone mineral density (BMD) and the bone turnover marker.</p><h3>Purpose</h3><p>To examine the associations of arterial stiffness, atherosclerotic plaque (ASP) and coronary artery calcification (CAC) parameters with BMD and bone resorption marker CTX.</p><h3>Methods</h3><p>Our cross-sectional study included 357 outpatient—women 45 to 82 years of age. Intima-media thickness (IMT), presence, and number of ASP in the carotid arteries were studied using duplex ultrasound imaging. Pulse wave velocity (PWV) and augmentation index (AI) were assessed via applanation tonometry method. Coronary artery calcification (CAC) on multislice computed tomography was scored using the Agatston calcium index (ACI). BMD was measured using by dual-energy X-ray absorptiometry (DXA). The C-terminal telopeptide of type 1 collagen (CTX) was investigated by enzyme-linked immunosorbent assay.</p><h3>Results</h3><p>Women with osteoporosis had higher IMT values (<i>p</i> = 0.045), more ASP (<i>p</i> &lt; 0.001), and higher ACI (<i>p</i> &lt; 0.001) than those with normal BMD values. In a multivariate linear regression analysis adjusted for age, duration of postmenopause, BMI, and levels of CTX and ALP in blood serum, we confirmed that ACI makes an independent contribution to the reduction in BMD of all measured parts of the skeleton, while IMT and the presence of ASP contribute to the reduction in BMD of femoral neck.</p><h3>Conclusion</h3><p>The results of our study demonstrated an association between vascular calcification, the presence of ASP in the carotid arteries and low bone mass in women without clinical manifestations of atherosclerosis, which is of clinical significance and important for the prevention of both osteoporotic fractures and cardiovascular incidents.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144811656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Femoral artery calcification predicts hip fracture in maintenance hemodialysis patients","authors":"Shun-Neng Hsu,&nbsp;Jhao-Jhuang Ding,&nbsp;Ping-Huang Tsai,&nbsp;Chia-Lin Yang,&nbsp;Chun-Liang Hsu,&nbsp;Yu-Juei Hsu","doi":"10.1007/s11657-025-01536-1","DOIUrl":"10.1007/s11657-025-01536-1","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>Femoral artery calcification (FAC) is a significant predictor of hip fractures in hemodialysis patients. A higher FAC score is associated with increased fracture risk and poor survival outcomes. Identifying FAC through radiographic assessment may improve fracture risk stratification and clinical management in this high-risk population.</p><h3>Purpose</h3><p>Patients with end-stage renal disease (ESRD) on hemodialysis (HD) are at increased risk for vascular calcification (VC) and bone fractures. While previous studies have linked aortic calcification with hip fractures, the relationship between medium-caliber artery-femoral artery calcification (FAC) and fall-related hip fractures in HD patients remains unclear.</p><h3>Methods</h3><p>We retrospectively analyzed 170 HD patients who experienced falls and sought treatment in the emergency department (ED) between 2007 and 2014. The FAC score, representing the severity of femoral artery calcification, was calculated as the ratio of the total length of calcification plaques to the length of the femoral vessel visible on plain radiographs of the hip and femur. A logistic regression model assessed the association between FAC score and hip fracture risk, and receiver operating characteristic curve analysis evaluated its predictive power.</p><h3>Results</h3><p>Among the 130 patients meeting inclusion criteria, 55 had fall-related hip fractures. The incidence rate of hip fractures among dialysis patients was 6.18 cases per 1000 person-years by dividing the total number of hip fracture events by the cumulative dialysis duration (in years) of all enrolled patients. Fracture patients were older and had lower serum creatinine, sodium, and albumin levels but higher aspartate aminotransferase levels. The fracture group also had a higher FAC score (0.47 [IQR, 0.28 – 0.76] vs. 0.00 [IQR, 0.00 – 0.40], <i>p</i> &lt; 0.001). Multivariable analysis identified old age, heart failure with reduced ejection fraction (EF), and higher FAC scores as independent risk factors for hip fractures. Survival curves showed increased mortality among patients with higher FAC scores and hip fractures (<i>p</i> &lt; 0.01). Conclusion.</p><p>High FAC scores were associated with an increased risk of hip fractures in HD patients, independent of traditional risk factors, and were linked to poor survival outcomes.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12334447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144803302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteoporosis care in primary care settings: a national UK e-survey","authors":"Ashley Hawarden,&nbsp;Laurna Bullock,&nbsp;Natasha Marie Cox,&nbsp;Elaine Nicholls,&nbsp;Jo Protheroe,&nbsp;Clare Jinks,&nbsp;Zoe Paskins","doi":"10.1007/s11657-025-01591-8","DOIUrl":"10.1007/s11657-025-01591-8","url":null,"abstract":"<div><h3>Summary</h3><p>An electronic survey of 341 UK primary care staff identified barriers to evidence-based osteoporosis care including low confidence in clinical skills, the complex nature of decision-making, insufficient incentivisation and lack of systematic case finding. Opportunities to enhance osteoporosis care may include enhanced education and wider utilisation of the extended workforce.</p><h3>Purpose</h3><p>To investigate the beliefs, confidence and practices of general practice staff in the care of people with, or at increased risk of, osteoporotic fractures and the association between professional role and beliefs and confidence about osteoporosis care.</p><h3>Methods</h3><p>An electronic survey was designed and distributed to UK general practice staff, including healthcare professionals (HCPs) and non-healthcare professionals (non-HCPs). Content was informed by UK clinical guidelines, a scoping review and patient and clinical stakeholder input. Descriptive statistics and Fisher’s exact test were utilised for analysis, with free text responses analysed using reflexive thematic analysis.</p><h3>Results</h3><p>Three hundred forty-one responses were obtained (309 HCPs, 32 non-HCPs). Most responding HCPs (173, 62.2%) and non-HCPs (17, 70.8%) reported osteoporosis management of moderate priority. The majority of HCPs (228, 73.8%) agreed that they were worried about osteoporosis medicines causing unpleasant side effects. Most respondents (314, 98.7%) reported GPs as involved in osteoporosis care, followed by Pharmacists (241, 75.8%) and Practice Nurses (159, 50.0%). GPs and Pharmacists reported the highest level of agreement with confidence in osteoporosis medicine related skills. Fewer than a third of respondents reported systematic invitation of patients with risk factors (fracture, steroids or falls) for assessment. Free text responses indicated problems with communication between primary and secondary care, challenging decision-making, limited access to resources (e.g. DXA scan, dentistry) and insufficient incentivisation as barriers to delivery of recommended osteoporosis care.</p><h3>Conclusion</h3><p>Identified opportunities to improve osteoporosis care include improved education, incentivisation, automated case finding and involvement of the wider primary care workforce, particularly Pharmacists.\u0000</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12325544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144788142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The global burden of fractures and its underlying etiologies: results from and further analysis of the Global Burden of Disease Study 2021","authors":"Jing Yan,&nbsp;Fen Li,&nbsp;Jun Zhou,&nbsp;Yuanyuan Ding,&nbsp;Qiujun Qin,&nbsp;Chunlin Jin","doi":"10.1007/s11657-025-01596-3","DOIUrl":"10.1007/s11657-025-01596-3","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Summary&lt;/h3&gt;&lt;p&gt;Fractures can result in decreased quality of life and care requirements, all of which significantly affect patients and their families. Our results revealed that the global incident, prevalent, and YLDs cases of fractures have risen in both sexes. Policies that prioritize avoiding fractures at different anatomical sites should be developed.&lt;/p&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;p&gt;Fractures are a major contributor of disease burden and are predicted to rise significantly in the years to come. The purpose of this study was to estimate the global burden of fractures and analyze the changes of etiologies of fractures between 1990 and 2021.&lt;/p&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;p&gt;Based on the information collected from the Global Burden of Disease (GBD) 2021, this study analyzed both the number and age-standardized rate of incidence, prevalence, and years lived with disability (YLD) of fractures between 1990 and 2021 by sex, age group, anatomical site, GBD region, SDI region, and country. We used estimated annual percentage changes (EAPC) to calculate the trends of the age-standardized rate over the past 30 years.&lt;/p&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;p&gt;In 2021, the number of new cases of fractures was 172.79 million (95%UI 158.38–187.65), with 77.66 million (95%UI 70.53–85.15) cases in females and 95.12 million (95%UI 87.69–102.67) cases in males. The prevalent cases were 453.31 million (95%UI 421.17–486.12) globally. In addition, fractures caused 25.18 million (95%UI 17.28–34.62) YLDs among all ages in 2021, displaying an increasing trend with an EAPC of 1.1. However, there was a general decline in the age-standardized incidence rate (ASIR), age-standardized prevalence rate (ASPR), and age-standardized years lived with disability rate (ASYR) of fractures from 1990 to 2021. The ASIR, ASPR, and ASYR of fracture in 2021 were 2172.52 cases (95%UI 1995.20–2364.46) per 100,000 population, 5397.67 cases 95%UI (5022.63, 5787.16) per 100,000 population, and 300.19 cases (95%UI 205.86–412.53) per 100,000 population. Compared with other countries and territories, New Zealand (6197.81 cases (5391.24–7068.78) per 100,000 population) had the highest ASIR of fractures in 2021, followed by the Republic of Slovenia (5996.53 cases (5367.82–6640.29) per 100,000 population) and Australia 5420.39 cases (4684.64–6301.56) per 100,000 population). Even while we observed that males had more incident, prevalent, and YLDs cases of fractures than females; and higher ASIR, ASPR, and ASYR, it may not apply to fractures at different anatomical sites, such as fracture of hip and fracture of radius and/or ulna. Furthermore, our study revealed that ASIR, ASPR, and ASYR for females were higher than males after the ages of 55–59, 85–89, and 70–74, although the ASPR and ASYR rose with age for both females and males. Falls were the leading ASYR level 3 cause of fractures worldwide, but with a downward trend; road injuries and exposure to mechanical forces were the second and third main causes of fractures.&lt;/p&gt;&lt;h3","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144788144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}