Archives of Osteoporosis最新文献

{"title":"Assessing bone and muscle health and their association in a Mongolian population aged 40 and older: a pioneering observational study","authors":"Myadagmaa Jaalkhorol,&nbsp;Fanny Buckinx,&nbsp;Amarsaikhan Dashtseren,&nbsp;Seded Baatar,&nbsp;Nansalmaa Khaidav,&nbsp;Gerelmaa Ochirdorj,&nbsp;Bolormaa Darambazar,&nbsp;Batmunkh Batsaikhan,&nbsp;Uugantamir Munkhsonguuli,&nbsp;Bayarmagnai Lkhagvasuren,&nbsp;Bulgantuya Byambaa,&nbsp;Wu Qi Zhu,&nbsp;Shiirevnyamba Avirmed,&nbsp;Olivier Bruyere","doi":"10.1007/s11657-025-01548-x","DOIUrl":"10.1007/s11657-025-01548-x","url":null,"abstract":"<div><h3>Summary</h3><p>This study in Mongolia reveals that weaker grip strength and higher sarcopenia risk are linked to greater fracture risk and lower bone density. It highlights the crucial interplay between muscle and bone health, emphasizing the need for integrated musculoskeletal assessments to prevent fractures, especially in aging populations.</p><h3>Background</h3><p>Research on the relationship between bone and muscle health in low- and middle-income countries, particularly Central Asia, remains limited.</p><h3>Objectives</h3><p>To explore the correlation between muscle and bone health and to estimate the FRAX risk for major osteoporotic fractures (MOF) and hip fractures in the Mongolian population, stratified by age and sex.</p><h3>Methods</h3><p>A cross-sectional study was conducted in Ulaanbaatar and regional Mongolia from May to August 2024. Handgrip strength, sarcopenia risk (SARC-F) and bone mineral density using peripheral DXA (BMD T-score) were assessed. Fracture risks were estimated using the FRAX model.</p><h3>Results</h3><p>Participants (<i>n</i> = 857; median age, 52 years; 53.0% women) had a median grip strength of 28 kg and a median BMD T-score of − 1.9. Most (69.5%) were at low sarcopenia risk (SARC-F &lt; 4). SARC-F was moderately correlated with FRAX scores for MOF and hip fractures (<i>r</i> ≈ 0.27, <i>p</i> &lt; 0.001) while grip strength was negatively correlated with FRAX scores(<i>r</i> =  − 0.24, <i>p</i> &lt; 0.001). Grip strength positively correlated with BMD T-scores (<i>r</i> = 0.22, <i>p</i> &lt; 0.001). Fracture risks increased with age, with women showing higher rates than men. Higher sarcopenia risk (SARC-F ≥ 4) was associated with lower BMD and increased fracture risk. Lower grip strength (&lt; 18 kg for women, &lt; 28 kg for men) was linked to higher fracture risk and lower BMD.</p><h3>Conclusions</h3><p>This study highlights the interconnected nature of muscle and bone health in the Mongolian population, demonstrating that lower grip strength and higher sarcopenia risk are significantly associated with increased fracture risk and reduced bone density. These findings underscore the importance of integrated strategies for musculoskeletal health assessment and fracture prevention, particularly in aging populations.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143913828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and predictors of osteosarcopenia and relationship with physical functionality in rural and urban Indian women","authors":"Gauri Bhat,&nbsp;Alex Ireland,&nbsp;Nikhil Shah,&nbsp;Ketan Gondhalekar,&nbsp;Anuradha Khadilkar","doi":"10.1007/s11657-025-01547-y","DOIUrl":"10.1007/s11657-025-01547-y","url":null,"abstract":"<div><h3>Summary</h3><p>Age-related bone and muscle impairments lead to osteoporosis and sarcopenia, and their coexistence, osteosarcopenia, causes functional decline but is less studied. We found higher prevalence of osteosarcopenia in rural (13.9%) vs urban women (1.6%), with risk factors including older age, low BMI, tobacco use, low protein, and low socioeconomic status.</p><h3>Background</h3><p>With ageing, bone and muscle impairment leading to osteoporosis and sarcopenia often co-exist, increasing risk of falls/fractures, physical disability, and premature mortality. Osteosarcopenia, where osteoporosis and sarcopenia co-exist, and its relationship with physical functionality in older adults is relatively less explored. Hence, we aimed to assess the prevalence, predictors, and physical functionality in urban and rural women with osteosarcopenia.</p><h3>Methods</h3><p>We included 397 women &gt; 40 years (182 urban, 215 rural, mean age 52 ± 7) from Pune and nearby villages. Height, weight, BMI, bone density (lumbar spine, femur via DXA), grip strength (JAMAR dynamometer), and muscle function (SPPB) were assessed. Sarcopenia and osteoporosis were diagnosed using AWGS and WHO guidelines, with osteosarcopenia defined as both conditions. Lifestyle factors (diet, physical activity, tobacco use, socioeconomic status) were evaluated by validated questionnaire.</p><h3>Results</h3><p>Rural women had higher rates of osteoporosis (42%), sarcopenia (19%), and osteosarcopenia (13.9%) compared to urban women (18%, 3.8%, and 1.6%, respectively). Sarcopenic women had nearly 6 times higher risk (OR = 6.2, 95%CI = 3.2–11.9, p = 0.001) of developing osteoporosis, with the risk remaining significant after adjusting for age and location. Osteosarcopenic women showed impaired physical function and lower bone density, with older age and low BMI as key risk factors.</p><h3>Conclusion</h3><p>Rural Indian women showed high rates of osteosarcopenia, osteoporosis, and sarcopenia, with older, low-BMI, postmenopausal women at higher risk. Contributing factors included low socioeconomic status, tobacco use, and poor protein intake. Addressing modifiable risks is important to reduce frailty-related outcomes in rural population.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143913856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"National guidelines for diagnosis and treatment of osteoporosis in Slovakia","authors":"Juraj Payer,&nbsp;Peter Jackuliak,&nbsp;Peter Vaňuga,&nbsp;Zdenko Killinger,&nbsp;Soňa Dubecká,&nbsp;Martin Kužma","doi":"10.1007/s11657-025-01538-z","DOIUrl":"10.1007/s11657-025-01538-z","url":null,"abstract":"<div><h3>Background</h3><p>Osteoporosis is a chronic, systemic skeletal disease characterized by decreased bone mass and microarchitectural deterioration, leading to increased fracture risk. In Slovakia, its prevalence is estimated at 6%, with substantial health, social, and economic burdens.</p><h3>Objective</h3><p>The Slovak national guideline provides an overview for the diagnosis, prevention, and treatment of osteoporosis in Slovakia, reflecting recent scientific advances and recommendations from international bodies.</p><h3>Methods</h3><p>The guidelines were developed by a multidisciplinary expert panel and officially adopted by the Ministry of Health of the Slovak Republic. They are based on current evidence and international standards, including FRAX, IOF, ISCD, and ESCEO recommendations.</p><h3>Results</h3><p>Diagnosis involves clinical risk assessment, biochemical testing, and imaging—primarily DXA and trabecular bone score. FRAX with or without BMD enhances risk stratification. Osteoporosis is categorized as primary or secondary. Prevention strategies include lifestyle modification, calcium and vitamin D supplementation, and fall risk reduction. Pharmacologic treatment includes antiresorptive agents (bisphosphonates, denosumab, SERMs), osteoanabolic (teriparatide, romosozumab), and hormone therapy when indicated. Sequential treatment strategies are emphasized, particularly in high-risk individuals. Treatment monitoring includes bone turnover markers and periodic DXA.</p><h3> Conclusions</h3><p>The Slovak guidelines provide a comprehensive and pragmatic approach for the management of osteoporosis across all stages, emphasizing early diagnosis, personalized treatment, and long-term fracture prevention. They align with European and global best practices and support clinical decision-making across specialties.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11657-025-01538-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143902709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between anemia, hemoglobin level and risk of osteosarcopenia in community-dwelling older adults: the Bushehr Elderly Health (BEH) program","authors":"Mohamad Gholizade,&nbsp;Maryam Marzban,&nbsp;Ali Jamshidi,&nbsp;Alireza Afshar,&nbsp;Mohammadreza Afshar,&nbsp;Mohammadreza Kalantarhormozi,&nbsp;Iraj Nabipour,&nbsp;Bagher Larijani,&nbsp;Akram Farhadi","doi":"10.1007/s11657-025-01535-2","DOIUrl":"10.1007/s11657-025-01535-2","url":null,"abstract":"<div><h3>Summary</h3><p>This study investigates the relationship between anemia, hemoglobin levels, and osteosarcopenia risk in older adults. Analyzing data from 2,398 participants in the Bushehr Elderly Health program, the research reveals that anemia significantly increases osteosarcopenia risk. The findings suggest that routine hemoglobin screening and anemia treatment could help prevent osteosarcopenia in the elderly population.</p><h3>Purpose</h3><p>In the older adult population, osteosarcopenia, defined as having both sarcopenia and osteopenia, is a recent concern. In this study, we aimed to evaluate anemia as a common condition in the older adult population and osteosarcopenia. Given that anemia can contribute to musculoskeletal decline through impaired oxygen delivery and metabolic dysfunction, we hypothesized that lower hemoglobin levels and anemia may be significant risk factors for osteosarcopenia. This study aims to investigate this potential relationship in an elderly population.</p><h3>Methods</h3><p>This cross-sectional study was conducted on men and women ≥ 60 years, based on the second phase of the Bushehr elderly health (BEH) program. Osteopenia/osteoporosis was defined as a t-score ≤—1.0 standard deviation below the mean values of a young healthy adult and sarcopenia was defined based on the revised edition of the European Working Group on Sarcopenia in Older People (EWGSOP2) based on the Iranian cut-off point. Anemia is defined as 12 for women and 13 g/dl for men. We calculated odds ratios (OR), 95% confidence intervals (95% CI), and adjusted OR (AOR) using univariate and adjusted multivariate logistic regression.</p><h3>Results</h3><p>Among 2398 who enrolled, 534 (22.27%) of participants had osteosarcopenia. The mean level of hemoglobin (Hgb) was 14.49 ± 1.73, and 219 participants (9.13%) were diagnosed with anemia. Participants with osteosarcopenia were more likely to be older, have lower body mass index, suffer from frailty syndrome and cognitive disorder, and have anemia. Moreover, analysis showed lower levels of Hgb were associated with osteosarcopenia (AOR = 0.89, 95% CI: 0.82–0.96) and anemia almost increase 1.5 times risk of osteosarcopenia (AOR = 1.55, 95% CI: 1.05–2.30).</p><h3>Conclusion</h3><p>The results of this study indicate that anemia dramatically increased the risk of osteosarcopenia. Routine Hgb screening and treatment of anemia might prevent the older adult population from osteosarcopenia.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143888699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare presentation of bilateral supracondylar femoral fractures in an individual with chronic spinal cord injury","authors":"Ijaz N. Pillai,&nbsp;Manjari E. Paulson,&nbsp;N. C. Chandini","doi":"10.1007/s11657-025-01540-5","DOIUrl":"10.1007/s11657-025-01540-5","url":null,"abstract":"<div><h3>Introduction</h3><p>Osteoporosis is a disease characterized by low bone mass and fracture of the bones irrespective of the aetiology. Insufficient data is available on the management of osteoporosis specific to individuals with spinal cord injury (SCI).</p><h3>Case Report</h3><p>The case describes a 24-year-old gentleman with a chronic spinal cord injury of 3-year duration, who was poorly evaluated and underwent unsupervised trial of therapeutic standing, resulting in a symmetrical supracondylar femoral fragility fracture. The assessment and management of the fractures and subsequent hemarthroses are also described in detail.</p><h3>Discussion</h3><p>Research shows mechanical loading of long bones in the lower extremity has the potential to reverse the osteoporotic process in SCI. However, ungraded and unsafe loading of joints following prolonged immobilization in individuals with chronic SCI, however may increase the risk of lower extremity fractures if appropriate measures for osteoporosis screening and treatment are not done.</p><h3>Conclusion</h3><p>This case report attempts to shine light on the need for proper evaluation to rule out osteoporosis prior to weight bearing or strenuous activity in this patient population, as well as the urgent need for timely mobilization and rehabilitation. Further research on weight bearing following chronic spinal cord injury is required to ascertain precise guidelines on timely loading of joints and prevent complications such as osteoporosis and fragility fractures. </p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143861392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of social determinants on osteoporosis treatment and secondary fracture risk after primary fragility fractures","authors":"Hannah L. Kralles,&nbsp;Amy Y. Zhao,&nbsp;Alex Gu,&nbsp;Amil R. Agarwal,&nbsp;Savyasachi C. Thakkar","doi":"10.1007/s11657-025-01539-y","DOIUrl":"10.1007/s11657-025-01539-y","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>This study examined the impact of social determinants of health (SDOH) on osteoporosis management and secondary fractures after primary fragility fractures. Despite similar osteoporosis treatment rates between patients with and without adverse SDOH, patients with adverse SDOH experienced significantly higher secondary fracture rates, highlighting the need for targeted interventions to improve post-fracture care in socioeconomically disadvantaged populations.</p><h3>Purpose</h3><p>Osteoporosis is a global health concern affecting over 500 million people. Fragility fractures are often the first indication of osteoporosis and are associated with significant morbidity and mortality. While low socioeconomic status is associated with increased risk of fragility fractures, the impact of social determinants of health (SDOH) on osteoporosis treatment and secondary fracture rates following primary fragility fractures remains unclear.</p><h3>Methods</h3><p>Patients aged 50 and older who sustained primary fragility fractures and had no prior osteoporosis treatment were identified using a large national database. Patients were stratified by the presence of adverse SDOH. Kaplan–Meier and multivariate Cox proportional hazards regression analyses were performed to evaluate the cumulative incidence of osteoporosis treatment within 1 year (including bisphosphonates, biologics, parathyroid hormone analogs, estrogens, and selective estrogen receptor modulators) and rates of secondary fractures within two years.</p><h3>Results</h3><p>A total of 276,845 patients were included in this study. Overall, 4.4% of patients with adverse SDOH and 5.3% of patients without were prescribed osteoporosis treatment within a year of fracture; however, this difference was not significant after controlling for confounders (hazard ratio (HR) 0.98; <i>P</i> = 0.82). Patients with adverse SDOH had significantly higher rates of secondary fractures within 2 years (7.4% versus 6.0%; HR 1.29; <i>P</i> &lt; 0.001).</p><h3>Conclusion</h3><p>Adverse SDOH were associated with increased rates of secondary fractures among patients with primary fragility fractures, despite similar osteoporosis management rates between groups. Overall, osteoporosis treatment rates remain low. Targeted strategies to optimize secondary prevention and tailored interventions are needed, particularly for socioeconomically disadvantaged populations.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143861393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orbital inflammation following zoledronic acid infusion","authors":"Angelina Liu,&nbsp;Chase Paulson,&nbsp;Ethan Krauspe,&nbsp;Madison Perchik,&nbsp;Jordan Desautels,&nbsp;Aaron Crosby","doi":"10.1007/s11657-025-01523-6","DOIUrl":"10.1007/s11657-025-01523-6","url":null,"abstract":"<div><h3>Introduction</h3><p>Bisphosphonates, including zoledronic acid, are widely used for the treatment of osteoporosis, Paget’s disease, and malignant bone metastases by inhibiting osteoclast-mediated bone resorption. While bisphosphonates are commonly associated with mild side effects such as fever, more severe complications like osteonecrosis of the jaw and hypocalcemia are less common but possible. A rare but clinically significant potential adverse effect that has previously been reported is orbital inflammation (OI), with patients presenting with symptoms of eye pain, orbital swelling, and conjunctival injection.</p><h3>Case Report</h3><p>This case report details the experience of a 76-year-old man who developed OI after his first zoledronic acid infusion for osteoporosis. The patient presented with left eye pain, swelling, and diplopia 2 days post-infusion, along with systemic symptoms of chills and vomiting. MRI confirmed orbital inflammation, and elevated inflammatory markers were noted with no evidence of systemic infection or autoimmune disease. The patient was treated with IV methylprednisolone (1000 mg daily for 3 days), leading to significant symptom improvement within 12 h. A subsequent 7-week prednisone taper was well-tolerated, with full resolution of symptoms at follow-up.</p><h3>Discussion</h3><p>This report underscores both the importance of recognizing rare events such as OI after ZA infusion and uncertainty about the best treatment regimen. While corticosteroids are the mainstay of treatment for OI, corticosteroids are deleterious for bone health and there is no consensus on optimal dosing or tapering duration. Given the clinical importance of bisphosphonates, clinicians should be aware of this potential adverse effect and consider standardized management protocols.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of ChatGPT in osteoporosis management: a comparative analysis with clinical expertise","authors":"Ömer Faruk Bucak,&nbsp;Cigdem Cinar","doi":"10.1007/s11657-025-01533-4","DOIUrl":"10.1007/s11657-025-01533-4","url":null,"abstract":"<div><h3>Summary</h3><p>This study evaluates the role of ChatGPT in osteoporosis management, demonstrating 91% diagnostic accuracy and significantly faster response times compared to clinicians. The findings highlight the potential for artificial intelligence (AI) to revolutionize clinical decision-making while emphasizing the critical need for professional oversight to ensure patient safety and comprehensive care.</p><h3>Objective</h3><p>Osteoporosis is a progressive skeletal disease that is characterized by increased bone fragility and an increased risk of fracture. Early diagnosis and effective treatment can significantly reduce healthcare costs; however, limited access to clinical expertise represents a significant challenge to patient care. This study evaluates the diagnostic and treatment recommendations provided by natural language processing (NLP)-based AI models for osteoporosis management and compares them with those of healthcare professionals.</p><h3>Methods</h3><p>A multicenter, cross-sectional study was conducted with the creation of 100 real scenarios from 206 patients with a diagnosis of osteoporosis. The data pertaining to bone mineral density (BMD) and the clinical parameters were subjected to analysis using ChatGPT-4.0. Thereafter, the recommendations proffered by this software were compared to those of five independent physiatrists. A statistical validation of the model’s accuracy was conducted through the use of categorical distribution analysis.</p><h3>Results</h3><p>ChatGPT exhibited a high degree of diagnostic accuracy, with 91% of responses being entirely accurate. It provided recommendations for both pharmacological and non-pharmacological interventions that were consistent with current clinical guidelines. Nevertheless, 8% of the responses were reported as incomplete. Furthermore, ChatGPT was able to produce diagnoses and treatment recommendations at a significantly faster rate than clinicians, while the mean answer time is 5.4 ± 2.45 min in clinicians and 2.3 ± 0.76 min in ChatGPT (<i>p</i> &lt; 0.001).</p><h3>Conclusion</h3><p>These findings highlight the potential of AI tools like ChatGPT to improve efficiency in clinical decision-making while underscoring the necessity of collaboration with healthcare professionals to guarantee comprehensive patient care.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hospitalisation from fractures in New Zealand octogenarians: LiLACS NZ","authors":"Catherine J. Bacon,&nbsp;Simon A. Moyes,&nbsp;Joanna Hikaka,&nbsp;Ruth Teh,&nbsp;Astrid E. A. Atlasz,&nbsp;Ngaire Kerse","doi":"10.1007/s11657-025-01528-1","DOIUrl":"10.1007/s11657-025-01528-1","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>Longitudinal data quantifying fracture rates beyond 80 years are lacking. Over 5 years, hospitalised fracture incidences increased by 85% in Māori and 73% in non-Māori octogenarians. However, while fracture-related hospital nights increased by 107% in non-Māori, they remained stable for Māori. Hospitalised fracture risk increases markedly with 5 years of advanced ageing.</p><h3>Purpose</h3><p>Fractures become increasingly common in people beyond 80 years, the most serious resulting in hospitalisation. This study examines longitudinal changes in hospitalised fractures in octogenarians.</p><h3>Methods</h3><p>Hospital discharge records from a cohort study of Māori aged 80–90 years and non-Māori turning 85 years (LiLACS NZ) were used to determine the incidence of hospitalised fractures for 5 years before and 5 years after enrolment.</p><h3>Results</h3><p>Records were available for 378 Māori (aged 82.6 ± 2.8 years; mean ± SD) and 498 non-Māori (84.6 ± 0.5 years). In the 5 years prior to enrolment, 22 (5.8%) Māori and 43 (8.6%) non-Māori were hospitalised at least once for fracture, and 29 (7.7%) Māori and 62 (12.4%) non-Māori sustained hospitalised fractures in the 5 years following enrolment. Hospitalised fracture incidences were 1270/100,000 person-years in Māori and 2048/100,000 person-years in non-Māori before enrolment, increasing to 2345 (<i>P</i> = 0.02) and 3541 (P = 0.002) /100,000 person-years in the subsequent 5 years, respectively. Pelvis/femoral fractures accounted for almost half (47%) of fractures. Fracture-related hospital nights increased 107% in non-Māori (<i>P</i> &lt; 0.0001), but remained stable for Māori, from before to after enrolment. Following enrolment, 21% of hospital nights spent by non-Māori women were fracture-related.</p><h3>Conclusion</h3><p>In octogenarians, hospitalised fracture risk increased markedly with 5 years of ageing, almost doubling fracture-related hospitalisation time in non-Māori but having little effect on time spent in hospital for Māori. Projections of fracture burden in advanced age need to consider rapidly changing risk with small increases in age and differences between demographic groups.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11657-025-01528-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful cryoablation for a phosphaturic mesenchymal tumor in the maxilla causing tumor-induced osteomalacia: a case report","authors":"Yindong Liu,&nbsp;Mengyao Guo,&nbsp;Xiaoding Liu,&nbsp;Huanwen Wu,&nbsp;Yan Jiang,&nbsp;Zhiwei Wang,&nbsp;Hongli Jing,&nbsp;Weibo Xia,&nbsp;Jizhi Zhao,&nbsp;Lian Zhou","doi":"10.1007/s11657-025-01525-4","DOIUrl":"10.1007/s11657-025-01525-4","url":null,"abstract":"<div><h3>Background</h3><p>A 35-year-old man was diagnosed with tumor-induced osteomalacia (TIO) caused by a phosphaturic mesenchymal tumor (PMT) in the right maxilla.</p><h3>Case Summary</h3><p>The patient underwent CT-guided cryoablation at our institution, which successfully eradicated the tumor while preserving the pulpal vitality of adjacent teeth. We describe the clinical history, physical examination findings, laboratory tests, functional imaging, and follow-up protocol for evaluating treatment outcomes. Cryoablation demonstrated therapeutic efficacy through symptomatic relief, normalization of serum phosphorus levels, and maintenance of pulpal vitality, as well as preservation of neighboring natural teeth.</p><h3>Conclusion</h3><p>Although extensive surgical resection remains the standard treatment for PMTs in jaw bones, image-guided cryoablation presents a minimally invasive alternative. This approach offers significant advantages in preserving occlusal anatomy and functionality, marking a paradigm shift in TIO management.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}