Archives of Osteoporosis最新文献

{"title":"Assessment of osteoporosis and vertebral fractures with T1- and T2-weighted MRI scans","authors":"Rahman Ud Din,&nbsp;Ling Wang,&nbsp;Xiaoguang Cheng,&nbsp;Haisheng Yang","doi":"10.1007/s11657-025-01509-4","DOIUrl":"10.1007/s11657-025-01509-4","url":null,"abstract":"<div><h3>Summary</h3><p>Osteoporosis is related to changes in vertebral bone marrow tissues, which can be detected by MRI. A novel MRI scoring method based on routine T1 and T2 sequences has been developed and demonstrated capabilities in detecting osteoporosis and discriminating vertebral fractures. The scoring method may provide an alternative tool other than BMD measurement for broad, opportunistic use in clinics.</p><h3>Purpose</h3><p>As a routinely used radiation-free modality at the spine, magnetic resonance imaging (MRI) is promising to assess osteoporosis because it can detect age- or osteoporosis-related changes in bone marrow tissues. Here, we proposed a new MRI scoring method using the patient’s low-back subcutaneous fat and cerebrospinal fluid as reference controls on routine T1 and T2 sequences, respectively, to indicate proton-rich changes in vertebrae for assessing osteoporosis and vertebral fractures.</p><h3>Methods</h3><p>The study included 60 female patients (64.1 ± 15.9 years) who underwent both MRI and quantitative computed tomography (QCT) at spine. T1-based F-score_sc.fat and T2-based W-score_cs.fluid were defined as the median signal intensity (SI) from L1 to L5 over their reference controls. QCT-measured vertebral BMD was used for defining osteoporosis. Receiver operating characteristic (ROC) analysis was performed to evaluate the diagnostic performances of the new scores for osteoporosis and vertebral fractures, which were also compared with L1–L5 signal-to-noise ratio (SNR_L1−L5) or SNR-based vertebral bone quality (VBQ) score.</p><h3>Results</h3><p>The F-score_sc.fat and W-score_cs.fluid increased significantly by 25.3% and 22%, respectively, in patients with osteoporosis compared to non-osteoporosis. Age was also found to be significantly different between non-osteoporosis and osteoporosis (49.92 and 74.03 years, <i>p</i> &lt; .001). ROC analysis indicated that F-score_sc.fat had a greater AUC value (0.85, <i>p</i> &lt; .001) than VBQ score (0.77) and SNR_L1−L5 (0.71) when being used to detect osteoporosis. For separating vertebral fractures from non-fractures, F-score_sc.fat resulted in the largest AUC value of 0.81 (<i>p</i> &lt; .001), compared to W-score_cs.fluid (0.74), VBQ (0.72), and SNR_L1−L5 (0.75).</p><h3>Conclusion</h3><p>A new MRI scoring method based on routine T1 and T2 sequences has been developed and demonstrated improved abilities in detecting osteoporosis and discriminating vertebral fractures over VBQ and SNR.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hip fractures in older patients: analysing the activity of an orthopaedic department to design an optimized pathway of fracture care","authors":"H. Temido,&nbsp;E. Coeckelberghs,&nbsp;R. Ramalho,&nbsp;R. Cavaca,&nbsp;A. Henriques,&nbsp;F. Fonseca,&nbsp;P. Boto","doi":"10.1007/s11657-025-01513-8","DOIUrl":"10.1007/s11657-025-01513-8","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>Substandard management of hip fractures in older patients has serious consequences in outcomes. Assessing care provided and institutional characteristics is essential to identify aspects to improve for better results. Delay to surgery, inadequate pain management, and delay in urinary catheter removal were especially inadequate and needed correction to better patient recovery.</p><h3>Introduction</h3><p>Hip fractures in older patients are a public health issue due to their prevalence and consequences. This study is an assessment of treatment currently provided to older patients with hip fractures in a tertiary hospital as a way of measuring standard care and guiding the design of a hospital-specific care pathway for the treatment of these patients.</p><h3>Methods</h3><p>A total of 250 patients over 65 years old were analysed. The overall population and its subgroups (early or late surgery and admitted to orthopaedic or non-orthopaedic ward) were characterized through descriptive statistical analysis, and the results were compared through inferential and regression analysis.</p><h3>Results</h3><p>Aspects requiring improvement were identified: inadequate pain management in the emergency department, increased time to surgery, excessive length of stay, increased time to first ambulation and to urinary catheter removal, medical complications and decrease in functional capacity at discharge. The mortality rate at discharge and up to 6 months was similar to what is described in the literature, in spite of the issues identified. Although further analysis is needed, some empirical reasons for these results are proposed.</p><h3>Discussion</h3><p>Some of the results described can be attributed to common hospital characteristics or non-modifiable patient characteristics but others can be corrected by suitable interventions.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ukrainian guideline for the prevention and treatment of glucocorticoid-induced osteoporosis","authors":"N. V. Grygorieva,&nbsp;V. M. Kovalenko,&nbsp;M. O. Кorzh,&nbsp;M. D. Tronko,&nbsp;I. Yu. Golovach,&nbsp;N. V. Dedukh,&nbsp;D. G. Rekalov,&nbsp;S. S. Strafun,&nbsp;S. I. Smiyan,&nbsp;O. A. Golubovska,&nbsp;Ya.O. Dziublyk,&nbsp;N. V. Kharchenko,&nbsp;G. O. Protsenko,&nbsp;O. O. Garmish,&nbsp;V. L. Orlenko,&nbsp;F. V. Klymovytskyy,&nbsp;A. S. Musiienko,&nbsp;T. A. Karasevska,&nbsp;Ukrainian Association of Osteoporosis","doi":"10.1007/s11657-025-01512-9","DOIUrl":"10.1007/s11657-025-01512-9","url":null,"abstract":"<div><h3>Introduction</h3><p>Glucocorticoid-induced osteoporosis (GIOP) is a bone metabolic disorder caused by glucocorticoid (GC) use. It is one of the leading causes of secondary osteoporosis, increasing the risk of low-energy fractures, disability, and mortality. Although limited studies on GIOP epidemiology and treatment have been conducted in Ukraine, there were no national guidelines for its management. The aim was to create national guideline for the GIOP diagnosis, prevention, and treatment based on a comprehensive review of modern literature to enhance awareness within Ukraine’s medical community, improve disease management, and reduce its socio-economic impact.</p><h3>Materials and methods</h3><p>An Expert Group comprising 18 leading Ukrainian scientists from various fields was created for guideline development. A review of modern literature on GIOP epidemiology, risk factors, diagnosis, prevention, treatment, and monitoring was conducted. Evidence synthesis followed the <i>GRADE</i> methodology, and the quality of recommendations was critically evaluated using the <i>AGREE II tool</i>.</p><h3>Results</h3><p>The guideline comprises 12 statements covering GIOP screening, diagnosis, prevention, and treatment. We highlight the need to raise awareness among healthcare providers and patients about the potential effects of GC therapy. Also, we outline approaches to clinical assessment of osteoporotic fracture risk in GC users and detail diagnostic and therapeutic methods currently available in Ukraine for managing GIOP.</p><h3>Conclusion</h3><p>The first Ukrainian national GIOP guideline is critical for healthcare providers across specialities. Endorsed by the Board of the Ukrainian Association of Osteoporosis, it is recommended for use in routine clinical practice to enhance patient outcomes and mitigate the disease’s impact.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The management of osteoporosis in hospitalized patients with fragility hip fractures in western Saudi Arabia: a real-world tertiary center experience","authors":"Fayez S. Alharthy,&nbsp;Abdullah Almalki,&nbsp;Eman A. Alsindi,&nbsp;Saeed S. Majadah,&nbsp;Sahar S. Alahmadi,&nbsp;Renad F. Alharthy,&nbsp;Salwa B. Alaidarous","doi":"10.1007/s11657-025-01511-w","DOIUrl":"10.1007/s11657-025-01511-w","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>Osteoporotic fractures, especially fragility hip fractures, are major causes of mortality and morbidity in the elderly. There is a significant gap in the diagnosis and treatment of osteoporosis in patients with fragility fractures. Vitamin D use increased by 18.2% post-admission, while calcium use rose by 21.1%. Additionally, the prescription of bisphosphonates, an osteoclast inhibitor, increased by 1.2% post-admission. The study highlights the urgent need for improved management practices and more proactive care strategies to address osteoporosis and its complications.</p><h3>Introduction</h3><p>Osteoporotic fractures are a major cause of fragility hip fractures, and in Saudi Arabia, the high prevalence of osteoporosis and high costs highlight the need for comprehensive care. This study aimed to evaluate the management of osteoporosis in hospitalized patients with fragility hip fractures in western Saudi Arabia.</p><h3>Methods</h3><p>This retrospective cohort study examined medical records from individuals with fragility hip fractures at King Abdulaziz Medical City in Saudi Arabia, Jeddah, from 2004 to 2024. Data was collected from electronic health records, including demographics, clinical features, comorbidities, fall history, osteoporosis diagnosis, and medication usage.</p><h3>Results</h3><p>The study included 314 patients, with a mean age of 73 years and 31.2% being between 71 and 80 years old. The majority were females, with a mean BMI of 26.6 kg/m². The most common comorbidity was renal failure. The prevalence of pre-admission diagnosis of osteoporosis was 14%. Post-admission DEXA-BMD use was reported by 16.6%. Vitamin D (41.1%) and calcium (42.4%) were higher in post-admission management compared to pre-admission management.</p><h3>Conclusion</h3><p>The study found that most hospitalized patients with fragility hip fractures were female, overweight, had a history of falls, and suffered from renal failure. This study opens new areas for future research that could increase our understanding of osteoporosis management.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143465940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between the number of chronic conditions and treatment of patients who are at high risk for future fracture in the Ontario Fracture Screening and Prevention Program (FSPP)","authors":"Anum Ali,&nbsp;Ella Huszti,&nbsp;Shahryar Noordin,&nbsp;Earl Bogoch,&nbsp;Alan Yang,&nbsp;Ravi Jain,&nbsp;Jennifer Weldon,&nbsp;Joanna E. M. Sale","doi":"10.1007/s11657-025-01503-w","DOIUrl":"10.1007/s11657-025-01503-w","url":null,"abstract":"<div><h3>Summary</h3><p>We compared medication prescription and initiation proportions among high-risk Fracture Screening and Prevention Program patients with multiple chronic conditions. Patients with two conditions were more likely to receive prescriptions and initiate prescribed medication than those with none. Post hoc analysis showed that patients with ≥ 3 conditions were less likely to be prescribed and to initiate medication, compared to those with two conditions. Tailored interventions are important for improving post-fracture care outcomes.</p><h3>Purpose</h3><p>To investigate the association between the number of chronic conditions and pharmacological treatment outcomes in high-risk patients who were screened through the Fracture Screening and Prevention Program (FSPP).</p><h3>Methods</h3><p>A retrospective cohort study was employed to determine the association between the number of chronic conditions and treatment outcomes. All high-risk patients who were enrolled in the FSPP between June 1, 2017, and June 30, 2022, were included in the study. The number of self-reported chronic conditions available in the FSPP data was classified into four categories: (1) 0 condition; (2) 1 condition; (3) 2 conditions; and (4) ≥ 3 conditions. Multivariable logistic regression models were created with prescription and initiation as outcomes.</p><h3>Results</h3><p>In total, 11,245 patients were identified as high-risk for future fracture. Patients with two chronic conditions demonstrated a 26% higher odds of receiving a medication prescription, and those with two chronic conditions and prescribed bone-active medication had a 57% increased odds of initiating the treatment compared to individuals without chronic conditions. No significant differences in medication prescription or initiation were seen in those with 1 or ≥ 3 chronic conditions compared to those without chronic conditions. In post hoc testing, we saw a 25–30% significantly lower odds of medication prescription and initiation in patients reporting ≥ 3 chronic conditions when compared to those who reported only two chronic conditions.</p><h3>Conclusion</h3><p>The findings suggest that a large provincial secondary fracture prevention program resulted in higher odds of prescription and initiation of treatment in patients with two chronic conditions compared to those having no chronic conditions. Potential inequities in these treatment outcomes were found with a threshold of three or more chronic conditions. This highlights the need for tailored interventions and comprehensive support systems to improve fracture prevention outcomes for high-risk patients with multiple chronic conditions.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11657-025-01503-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143446458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term effect of sunshine duration on daily emergency visits for hip fractures in Beijing, China: a time-series study","authors":"Jia Chen,&nbsp;Xue-Jiao Liu,&nbsp;Geng Liu,&nbsp;Ning Li,&nbsp;Wei Deng,&nbsp;Xiao-Jie Xu,&nbsp;Jing-Hong Gao,&nbsp;Yan-Lin Niu,&nbsp;Bai-Chao Zhang,&nbsp;Zhao-Xing Tian,&nbsp;Xie-Yuan Jiang","doi":"10.1007/s11657-024-01483-3","DOIUrl":"10.1007/s11657-024-01483-3","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>This study employs a time-series analysis to investigate how sunshine duration associates hip fractures in China and found both short and long durations of sunshine increased the risk of hip fractures. The findings can guide strategies for reducing hip fractures and enhance health education on fracture prevention.</p><h3>Background</h3><p>Studies on the associations between sunshine duration and emergency visits for hip fractures (HF) are limited. This study aimed to assess the short-term effect of sunshine duration on the risk of emergency visits for HF.</p><h3>Methods</h3><p>Daily emergency visits for HF at Beijing Jishuitan Hospital from 2015 to 2019 and contemporaneous meteorological and air pollutant data were collected. A Poisson generalized linear regression model combined with a distributed lag non-linear model was applied to analyze the lag-exposure–response relationship between sunshine duration and HF. Stratified analysis was performed by gender and age.</p><h3>Results</h3><p>A total of 10,874 cases were identified. The overall cumulative exposure–response curve showed a U-shaped relationship between sunshine duration and HF. With 7.2 h as the reference (lowest HF emergency visit risk), significant single-day effects of short sunshine duration (0 h, 2.5th percentile) were observed from the 11th to the 13th day, peaking on lag day 13 (RR = 1.033, 95% CI: 1.003–1.065), while its cumulative effects lasted from lag days 0–11 to 0–14, with the highest RR of 1.327 (95% CI: 1.088–1.619) at lag day 0–14. Significant single-day effects of long sunshine duration (12.7 h, 97.5th percentile) occurred from the 10th to the 12th day, peaking on the 12th day (RR = 1.030, 95% CI: 1.000–1.061), but no cumulative lag effects were found. This U-shaped pattern was consistent across subgroups, especially among female patients and those aged 66–79 years; conversely, the risk of HF-related emergency visits decreased with increasing sunshine duration in patients aged 40–65 years with a relatively high uncertainty.</p><h3>Conclusions</h3><p>Both short and long durations of sunshine are associated with an increased risk of HFs emergency visits. Females and patients aged 66–79 years might be more vulnerable to short sunshine duration.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143423262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of a fracture liaison service for patients with femoral fractures on subsequent fractures and mortality: focusing on systematic literature review and metaanalysis","authors":"Min Soo Kim,&nbsp;Jeong-Min Yang,&nbsp;Yonghan Cha,&nbsp;Seung Hoon Kim,&nbsp;Minah Park,&nbsp;Jae-Hyun Kim","doi":"10.1007/s11657-025-01505-8","DOIUrl":"10.1007/s11657-025-01505-8","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>The purpose of this study is to scientifically and systematically investigate the clinical effectiveness of a fracture liaison service (FLS) for patients with femoral fractures.</p><h3>Methods</h3><p>The international databases Ovid-MEDLINE, EMBASE, and The Cochrane Library and the Korean databases KISS, RISS, KoreaScience, Koreamed, and Kmbase were used. Risk of bias assessment was conducted at the study design level, and meta-analysis utilized both random-effects and fixed-effects models, along with subgroup analysis.</p><h3>Results</h3><p>From the 32 selected articles, 14 articles related to subsequent fracture and 18 articles related to mortality were included in the meta-analysis. As a result of the meta-analysis, the risk of subsequent fracture in the group that participated in the fracture liaison service was 46% lower than that in the non-participated group, and this difference was statistically significant (RR = 0.54, 95% CI = 0.50–0.59). The risk of death in the group that participated in the FLS was 17% lower than that in the non-participating group, and this difference was not statistically significant as well (RR = 0.83, 95% CI = 0.67–1.03). As a result of subgroup analysis, there was a statistically significant difference in the reduction of subsequent fracture in the clinical outcomes, and there was a significant difference in mortality in the intervention follow-up period and clinical outcomes.</p><h3>Conclusion</h3><p>The global implementation of FLS has played a crucial role in enhancing the clinical management and treatment of patients with femoral fractures, contributing to a decrease in subsequent fracture and mortality. This indicates the significant role of FLS in minimizing the disease burden associated with femoral fractures worldwide.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143423133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A surrogate FRAX model for Mongolia","authors":"M. Jaalkhorol,&nbsp;H. Johansson,&nbsp;S. Avirmed,&nbsp;A. Dashtseren,&nbsp;O. Bruyère,&nbsp;M. Lorentzon,&nbsp;N. C. Harvey,&nbsp;E. V. McCloskey,&nbsp;J. A. Kanis","doi":"10.1007/s11657-025-01501-y","DOIUrl":"10.1007/s11657-025-01501-y","url":null,"abstract":"<div><h3>Summary</h3><p>A surrogate FRAX® model for Mongolia has been constructed using age- and sex-specific hip fracture rates for mainland China and age- and sex-specific mortality rates from Mongolia.</p><h3>Introduction</h3><p>FRAX models are frequently requested for countries with little or no data on the incidence of hip fracture. In such circumstances, the development of a surrogate FRAX model is recommended based on country-specific mortality data but using fracture data from a country, usually within the region, where fracture rates are considered to be representative of the index country.</p><h3>Objective</h3><p>This report describes the development and characteristics of a surrogate FRAX model for Mongolia.</p><h3>Methods</h3><p>The FRAX model used the ethnic-specific incidence of hip fracture in mainland China, combined with the death risk for Mongolia in 2015–2019. Intervention thresholds were developed based on fracture probabilities equivalent to women with a prior fragility fracture, and their impact was assessed in a referral cohort comprising men at age 50 and above and postmenopausal women. The number of hip fractures in 2015 and 2050 was estimated based on United Nations’ predicted changes in population demography.</p><h3>Results</h3><p>The surrogate model gave similar hip fracture probabilities to estimates from China. Age-dependent intervention thresholds for a major osteoporotic fracture ranged from a 10-year probability of 2.4% at the age of 40 years to 13.7% at the age of 90 years. In the cohort of those eligible for assessment, 46% of men and 36% of women were eligible for treatment because of a prior fracture. Based on intervention thresholds, a further 0.5% of men and 7.0% of women would be eligible for treatment. It was estimated that 440 hip fractures arose in 2015 in individuals aged 50 years and older in Mongolia, with a predicted 4.3-fold increase expected by 2050, when 1896 hip fractures are expected nationally.</p><h3>Conclusion</h3><p>The surrogate FRAX model for Mongolia provides an opportunity to determine fracture probability within the Mongolian population and help guide decisions about treatment.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11657-025-01501-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143423261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiresorptive injections in older adult patients with prior osteoporotic fractures: a real-world observational study","authors":"Chun-Feng Huang,&nbsp;Shiue-Ming Lin,&nbsp;Jason C. Hsu,&nbsp;Russell O. Kosik,&nbsp;Wing P. Chan","doi":"10.1007/s11657-025-01510-x","DOIUrl":"10.1007/s11657-025-01510-x","url":null,"abstract":"<div><h3>\u0000 <i>Summary</i>\u0000 </h3><p>Injectable antiresorptive drugs may reduce refracture risk in older adults with previous fractures, though further research is needed to explore related factors, including the crucial role of consistent adherence.</p><h3>Purpose</h3><p>Osteoporosis increases fracture risk, particularly in older adults. Spinal and hip fractures are common and costly complications. To examine the effectiveness of parenteral antiresorptive medications—denosumab and zoledronate—in reducing refracture rates among older adults with prior spinal or hip fractures.</p><h3>Methods</h3><p>A nationwide retrospective cohort study was conducted using data from Taiwan’s National Health Insurance Research Database (2011–2020). Patients aged 50 and older with spinal or hip fractures were divided into a treatment group (received zoledronate or denosumab) and a control group (no osteoporosis treatment). A 1:1 matching based on age, sex, and Charlson Comorbidity Index was performed. Kaplan–Meier method and Cox proportional hazards regression were used for analysis.</p><h3>Results</h3><p>Out of 23,331 eligible patients, 582 were in the treatment group and 17,281 in the control group. After matching, 211 patients received zoledronate and 367 received denosumab. The treatment group showed a trend toward lower refracture risk compared to the control group, though not statistically significant. Hazard ratios were 0.63 for zoledronate and 0.80 for denosumab, indicating potential benefits. There was no substantial difference between the two medications.</p><h3>Conclusion</h3><p>This is the first real-world study to assess the effectiveness of complete adherence to parenteral antiresorptive medications in reducing the risk of refractures among older adults with prior spinal or hip fractures. However, further research is needed to confirm these findings and investigate long-term effects.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143423263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of the various physical activity patterns with low bone mineral density in Americans aged 20–60","authors":"Yi Wang,&nbsp;Ling Long,&nbsp;Lei Liu,&nbsp;Pan Fan,&nbsp;Xin Zheng,&nbsp;Xi Li,&nbsp;Yun-Tao Wang,&nbsp;Bao-Shan Xu,&nbsp;Yu-Ao Tao","doi":"10.1007/s11657-024-01479-z","DOIUrl":"10.1007/s11657-024-01479-z","url":null,"abstract":"<div><h3>Summary</h3><p>Through analyzing the data of the NHANES 2007–2020 cycle, this study concluded that high-intensity exercise 1–2 sessions a week can help maintain bone mass, and there is no significant difference from regular exercise more than 3 times a week.</p><h3>Purpose</h3><p>This study aims to explore the relationship between the various physical activity(PA) patterns and the risk of low bone mineral density(BMD) in Americans of working age.</p><h3>Method</h3><p>A total of 6482 participants aged 20–60 were selected from the National Health and Nutrition Survey (NHANES) conducted from 2007 to 2020. The PA data of the participants were obtained through individual interviews, and the participants were divided into four groups (inactive, insufficiently active, less frequent but sufficiently active(1–2 sessions a week and PA ≥ 150 min), and regularly active). Weighted logistic regression was used to analyze the correlation between PA patterns and the risk of low BMD. Subgroup analyses were applied to display the correlation between PA patterns and low BMD in different subgroups.</p><h3>Result</h3><p>After adjusting for confounding factors, the multiple logistic regression model showed that compared with inactive individuals, sufficiently active and regularly active individuals had a 35% (OR, 0.65; 95% CI, 0.46–0.92) and 24% (OR, 0.76; 95% CI, 0.62–0.93) lower risk of low BMD, respectively. Compared with regularly active adults, inactive adults had a 32% (OR, 1.32; 95% CI, 1.07–1.62) increased risk of low BMD, while sufficiently active individuals (OR, 0.85; 95% CI, 0.59–1.23) showed no significant difference compared with regularly active adults.</p><h3>Conclusion</h3><p>Compared with inactive adults, less frequent but sufficiently active adults have a lower risk of low BMD and showed benefits similar to those in regularly active groups. The sufficiently active pattern may become a new trend in modern working-age adults’ PA patterns.</p></div>","PeriodicalId":8283,"journal":{"name":"Archives of Osteoporosis","volume":"20 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143404244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}